UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-K
☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the fiscal year ended December 31, 2020
or
☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from to
Commission file number: 001-39102
TFF Pharmaceuticals, Inc.
(Exact name of registrant as specified in its charter)
Delaware
(State or Other Jurisdiction of
Incorporation or Organization)
82-4344737
(I.R.S. Employer
Identification Number)
2600 Via Fortuna, Suite 360
Austin, Texas 78746
(Address of principal executive offices)
(737) 802-1973
(Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of the Act:
Title of each class
Common stock: Par value $0.001
Trading Symbol(s)
TFFP
Name of each exchange on which registered
The Nasdaq Global Market
Securities registered pursuant to Section 12(g) of the Act:
None
Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒
Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act. Yes ☐ No ☒
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of
Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post
such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or
emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth
company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer
Non-accelerated filer
☐
☒
Accelerated filer
Smaller reporting company
Emerging growth company
☐
☒
☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new
or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control
over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or
issued its audit report. Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
State the aggregate market value of voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common
equity was last sold, or the average bid and asked price of such common equity, as of the last business day of the registrant’s most recently completed
second fiscal quarter: $83,662,145.
The number of shares of the registrant’s common stock outstanding as of March 5, 2021 was 23,139,900.
DOCUMENTS INCORPORATED BY REFERENCE
Portions of the registrant’s definitive proxy statement for the registrant’s 2021 Annual Meeting of Stockholders to be filed pursuant to Regulation 14A
within 120 days of the registrant’s year ended December 31, 2020 are incorporated herein by reference into Part III of this Annual Report on Form 10-K.
Item 1.
Item 1A.
Item 1.B.
Item 2.
Item 3.
Item 4.
Business
Risk Factors
Unresolved Staff Comments
Properties
Legal Proceedings
Mine Safety Disclosures
TABLE OF CONTENTS
PART I
PART II
Item 5.
Item 6.
Item 7.
Item 7A.
Item 8.
Item 9.
Item 9A.
Item 9B.
Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Selected Financial Data
Management’s Discussion and Analysis of Financial Condition and Results of Operations
Quantitative and Qualitative Disclosures About Market Risk
Financial Statements and Supplementary Data
Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
Controls and Procedures
Other Information
Item 10.
Item 11.
Item 12.
Item 13.
Item 14.
Directors, Executive Officers and Corporate Governance
Executive Compensation
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Certain Relationships and Related Transactions and Director Independence
Principal Accountant Fees and Services
PART III
Item 15.
Exhibits and Financial Statement Schedules
Signatures
PART IV
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This annual report on Form 10-K contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as
amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Those forward-looking statements include our expectations, beliefs,
intentions and strategies regarding the future. Such forward-looking statements relate to, among other things,
CAUTIONARY NOTICE
● our future financial and operating results;
● our intentions, expectations and beliefs regarding anticipated growth, market penetration and trends in our business;
● the timing and success of our plan of commercialization;
● our ability to successfully develop and clinically test our product candidates;
● our ability to file for FDA approval of our product candidates through the 505(b)(2) regulatory pathway;
● our ability to obtain FDA approval for any of our product candidates;
● our ability to comply with all U.S. and foreign regulations concerning the development, manufacture and sale of our product candidates;
● the adequacy of the current working capital;
● the effects of market conditions on our stock price and operating results;
● our ability to maintain, protect and enhance our intellectual property;
● the effects of increased competition in our market and our ability to compete effectively;
● costs associated with initiating and defending intellectual property infringement and other claims;
● the attraction and retention of qualified employees and key personnel;
● future acquisitions of or investments in complementary companies or technologies; and
● our ability to comply with evolving legal standards and regulations, particularly concerning requirements for being a public company.
These and other factors that may affect our financial results are discussed more fully in “Risk Factors” and “Management’s Discussion and
Analysis of Financial Condition and Results of Operations” included in this report. Moreover, we operate in a very competitive and rapidly changing
environment, and new risks emerge from time to time. It is not possible for us to predict all risks, nor can we assess the impact of all factors on our business
or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking
statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this report may
not occur and actual results could differ materially and adversely from those anticipated or implied in our forward-looking statements. Although we believe
that the expectations reflected in our forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance
or events and circumstances described in the forward-looking statements will be achieved or occur. Moreover, neither we nor any other person assumes
responsibility for the accuracy and completeness of the forward-looking statements. We caution readers not to place undue reliance on any forward-looking
statements. We do not undertake, and specifically disclaim any obligation, to update or revise such statements to reflect new circumstances or unanticipated
events as they occur, and we urge readers to review and consider disclosures we make in this and other reports that discuss factors germane to our business.
See in particular our reports on Forms 10-K, 10-Q, and 8-K subsequently filed from time to time with the Securities and Exchange Commission.
ii
Item 1. Business
Background
PART I
TFF Pharmaceuticals, Inc. was formed as a Delaware corporation on January 24, 2018 for the purpose of developing and commercializing
innovative drug products based on our patented Thin Film Freezing, or TFF, technology platform. We were formed by Lung Therapeutics, Inc., or LTI, an
early stage biotechnology company focused on the development of certain technologies in the pulmonary field. In March 2018, we completed a Series A
preferred stock financing with third-party investors, at which time we acquired certain of LTI’s non-core intellectual property rights and other assets, all of
which relate to our TFF technology, for 4,000,000 shares of our common stock. As of March 5, 2021, LTI owns 2,950,000 shares of our common stock, or
approximately 12.7% of our capital stock. We are no longer a subsidiary of LTI.
Since our formation, we have focused on the development of our initial drug candidates, the establishment of strategic relationships with
established pharmaceutical companies for the licensing of our TFF technology platform and the pursuit of additional working capital. We have not
commenced revenue-producing operations. Unless otherwise indicated, the terms “TFF Pharmaceuticals,” “Company,” “we,” “us,” and “our” refer to TFF
Pharmaceuticals, Inc. and its wholly-owned subsidiaries.
Since our organization in 2018, we have engaged in several capital raising transactions, which are summarized below in “Management’s
Discussion and Analysis of Financial Condition and Results of Operations – General.”
Overview
We are an early-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on our patented
Thin Film Freezing, or TFF technology platform. We believe, and early testing confirms, that our TFF platform can significantly improve the solubility of
poorly water-soluble drugs, a class of drugs that makes up approximately 33% of the major pharmaceuticals worldwide, thereby improving the
pharmacokinetic effect of those drugs. We believe that in the case of some new drugs that cannot be developed due to poor water-solubility, our TFF
platform has the potential to increase the pharmacokinetic effect of the drug to a level allowing for its development and commercialization. In November
2019, we initiated Phase I human clinical trials of our lead product, TFF Voriconazole Inhalation Powder, or VIP, completed the clinical portion of the
Phase 1 trial in July 2020 and progressed to a Phase 1b clinical trial in asthma patients in November 2020. In June 2020, we commenced Phase I human
clinical trials of our TFF Tacrolimus Inhalation Powder, or TIP, product in Melbourne, Victoria, Australia, but in July 2020, the Phase I trials of our TFF
TIP product were delayed due to a resurgence of COVID-19 in the Melbourne area. A second clinical trial site in Brisbane, Queensland, Australia was
opened and we resumed dosing in the Phase 1 clinical trials in Australia during the third quarter 2020. As of the date of this report, we have not progressed
the development of any other of our drug candidates to human clinical trials and our efforts have focused on the formulation, early stage animal testing and
formal toxicology studies of our initial drug candidates in preparation for our first clinical trials.
We intend to initially focus on the development of inhaled dry powder drugs for the treatment of pulmonary diseases and conditions. While the
TFF platform was designed to improve solubility of poorly water-soluble drugs generally, the researchers at University of Texas at Austin, or UT, found
that the technology was particularly useful in generating dry powder particles with properties which allow for superior inhalation delivery, especially to the
deep lung, which is an area of extreme interest in respiratory medicine. We believe that our TFF platform can significantly increase the number of
pulmonary drug products that can be delivered by way of breath-actuated inhalers, which are generally considered to be the most effective and patient-
friendly means of delivering medication directly to the lungs. Our dry powder drug products will be designed for use with dry powder inhalers, which are
generally considered to be the most effective of all breath-actuated inhalers. We plan to focus on developing inhaled dry powder formulations of existing
off-patent drugs intended for lung diseases and conditions, which we believe includes dozens of potential drug candidates, many of which have a potential
market ranging from $100 million to over $500 million.
We also focused on the joint development of dry powder formulations of proprietary drugs owned or licensed by other pharmaceutical companies.
As of the date of this report, we are at various stages of feasibility studies of new chemical entities with multiple international pharmaceutical companies.
In addition, we are actively engaged in the analysis and testing of dry powder formulations of certain drugs and vaccines through topical, ocular and nasal
applications in connection with our participation in submissions made to certain government agencies for government contracts.
1
Our business model is to develop proprietary innovative drug product candidates that offer commercial or functional advantages, or both, to
currently available alternatives. Because our initial dry powder drug candidates, TFF VIP and TFF TIP, will be established drugs that are off-patent, we
believe that our initial drug product candidates will qualify for approval by the U.S. Food and Drug Administration, or FDA, through the FDA’s 505(b)(2)
regulatory pathway and in corresponding regulatory paths in other foreign jurisdictions. The 505(b)(2) pathway sometimes does not require clinical trials
other than a bioequivalence trial. However, to the extent we claim that our product candidates target a new indication or offer improved safety compared to
the existing approved products, and it is our present expectation that we will in many cases, it is likely that we will be required to conduct additional
clinical trials in order to obtain marketing approval. For example, and as more fully described below, based on a February 2019 pre-Investigational New
Drug Application, or IND, meeting with the FDA concerning TFF VIP, we believe we will need to conduct Phase I and Phase II studies prior to filing for
marketing approval for TFF VIP. In addition, based on a September 2019 pre-IND meeting with the FDA concerning TFF TIP, we also believe we will
require Phase I and Phase IIb/IIIa studies prior to filing for marketing approval for TFF TIP. However, there can be no assurance that the FDA will not ask
for additional clinical data for either TFF VIP or TFF TIP.
While we intend to target the development of off-patent drugs for which we would directly pursue the development of a dry powder formulation
through the FDA’s 505(b)(2) regulatory pathway, not all of our product candidates will target off-patent drugs and, at least in the case of a dry powder
formulation of cannabidiol, or CBD, our product candidate may not be a drug. We do not expect our proposed dry powder formulation of CBD drug
product to be off-patent and our proposed dry powder formulation of aluminum salt vaccines may not be off-patent. We also expect that our dry powder
formulation of a CBD drug product will likely require a full New Drug Application, or NDA, through the FDA’s 505(b)(1) regulatory pathway; however, a
non-pharmaceutical CBD dry powder formulation, such as a dietary supplement, may not require FDA pre-market approval. We expect that our dry powder
formulation of aluminum salt vaccines will require a biological license application, or BLA, which is very similar to a full NDA through the FDA’s 505(b)
(1) regulatory pathway.
We also believe that in some cases our dry powder drug products may qualify for the FDA’s orphan drug status. Upon and subject to receipt of the
requisite approvals, we intend to commercialize our drug product candidates through a combination of our internal direct sales and third-party marketing
and distribution partnerships. In some cases, such as the development of combination drugs or the development of dry powder formulations of patented
drugs, we intend to pursue the licensing of our TFF platform or a joint development arrangement.
Our Intended Regulatory Pathway
The 505(b)(2) pathway is intended for molecules that have been previously approved by the FDA or have already been proven to be safe and
effective. A 505(b)(2) product reformulates the known molecule in a new strength or dosage form. 505(b)(2) products have the advantage of potentially
significantly lower development costs and shorter development timelines versus traditional new molecular entities. We expect to utilize the 505(b)(2)
pathway for all of our current product candidates.
A 505(b)(2) NDA is an application that contains full reports of investigations of safety and effectiveness, but where at least some of the
information required for approval comes from studies not conducted by or for the applicant. This alternate regulatory pathway enables the applicant to rely,
in part, on the FDA’s findings of safety and efficacy for an existing product, or published literature, in support of its application. A 505(b)(2) product
candidate might rely on the clinical studies or literature of a previously FDA-approved drug, or rely on the literature and physician usage of an FDA-
unapproved, or DESI, drug. The clinical requirements for a 505(b)(2) drug candidate can vary widely from product to product and may include new clinical
trials, bioequivalence trials, limited safety and efficacy trials, or full Phase I through III trials. Unless the FDA has released a guidance document, the
clinical requirement for a new product candidate is typically not known until the drug sponsor has a Pre-IND meeting with the FDA. We believe there is a
significant opportunity to pursue dry powder formulations of off-patent drugs using the 505(b)(2) regulatory pathway.
We also believe that in some cases the indication for some of our dry powder drug product candidates may qualify for the FDA’s orphan drug
status. Under the Orphan Drug Act, the FDA may grant orphan designation to a drug intended to treat a rare disease or condition generally affecting fewer
than 200,000 individuals in the United States, or in other limited cases. Orphan drug designation provides for seven years of exclusivity, independent of
patent protection, to the company that brings a particular orphan drug to market. In addition, companies developing orphan drugs are eligible for certain
incentives, including tax credits for qualified clinical testing. In addition, an NDA for a product that has received orphan drug designation is not subject to a
prescription drug user fee unless the application includes an indication other than the rare disease or condition for which the drug was designated.
2
The Problem We Address
Solubility is an issue that all drugs must address. No matter how active or potentially active a new drug is against a particular molecular target, if
the drug is not available in solution at the site of action, it is most likely not a viable development candidate. Based on independent third-party studies, 40%
of newly discovered drugs have little or no water solubility, and in some therapeutic areas this number can reach 90%, which in most cases will prohibit
development since most pharmaceutical companies cannot or will not conduct rigorous preclinical and clinical studies on a molecule that does not have a
sufficient pharmacokinetic profile due to poor water solubility. Water solubility can also be an issue for some marketed drugs. Based on independent third-
party studies, only two-thirds of the drugs on the World Health Organization, or WHO, Essential Drug List were classified as high solubility. A marketed
drug with poor water solubility can show performance limitations, such as incomplete or erratic absorption, poor bioavailability, and slow onset of action.
Effectiveness can vary from patient to patient, and there can be a strong effect of food on drug absorption. Finally, it may be necessary to increase the dose
of a poorly soluble drug to obtain the efficacy required, which can lead to adverse side effects, toxicity issues and increased costs.
In addition to water solubility issues generally, certain drugs that target lung conditions and diseases have poor solubility that prevent them from
being delivered by way of a breath-actuated inhaler and can only be given orally or intravenously. Breath actuated inhalers include dry powder inhalers,
metered dose inhalers and nebulizers. A dry powder inhaler (such as the Advair Diskus) delivers drugs in a dry powder form directly to the lungs by way of
a deep, fast breath on the mouth of the inhaler. A metered dose inhaler (such as the Symbicort asthma inhaler) uses propellant to push medication to the
lungs. A nebulizer (such as the Aeroneb Pro) creates a mist that is breathed into the lungs through a mouthpiece. The dry powder inhaler is generally
considered to be the most effective and convenient form of breath-actuated inhaler for all users, other than for those whose severe condition does not allow
them to take a sufficiently deep breath.
We believe the primary benefit of a breath-actuated inhaler is its ability to administer a greater portion of the drug dosage directly to the target site.
Dosing directly to the lungs has been shown to allow for better effect with fewer adverse events. In addition, it has been shown that dosing directly to the
lungs requires a much lower dose of drug, sometimes as little as 10%, compared to delivery by oral or parenteral routes. While breath-actuated inhalers
allow for a greater portion of the administered drug to reach the treatment site, which should allow for much smaller dosages compared to oral or
intravenous delivery, not all drugs targeting lung conditions and diseases can be formulated for use with a breath-actuated inhaler. We believe there are
dozens of off-patent drugs targeting lung conditions and diseases that are currently not eligible for delivery by way of breath-actuated inhalers, many of
which have a potential market of $100 million to over $500 million. This is the market we intend to initially address through our development of dry
powder drugs utilizing our TFF platform.
Our Thin Film Freezing Platform
Our development of dry powder drugs is enabled by technology licensed to us by the University of Texas at Austin, or UT. Researchers at UT
have developed a technology employing a process called Thin Film Freezing, or TFF. While the TFF platform was designed to improve solubility of poorly
water-soluble drugs generally, the researchers at UT found that the technology was particularly useful in generating dry powder particles with properties
suitable for inhalation delivery, especially to the deep lung, an area of extreme interest in respiratory medicine. It was found that the TFF platform yields
particles that are particularly well suited to dry powder inhaler delivery. The process results in a “Brittle Matrix Particle,” which possess low bulk density,
high surface area, and typically an amorphous morphology, allowing them to supersaturate when contacting the target site, such as lung tissue. The
aerodynamic properties of the particles are such that the portion of drug deposited to the deep lung may reach as high as 75% or greater of the administered
dose, compared to 10% or less when given orally or intravenously.
The TFF process, outlined in the figures below, involves dissolving a drug or drugs in a solvent system, and it will often include agents designed
to promote dispersion and avoid clumping and excipients to promote adhesion to the target site. The drug solution is then applied to a cryogenic substrate,
such as a liquid nitrogen cooled stainless steel drum. When the drug solution contacts the cryogenic surface it vitrifies, or flash freezes, resulting in a “drug
ice” typically with amorphous drug morphology. The solvent system is removed by lyophilization, resulting in Brittle Matrix Particles, shown in the
photographs below, that are highly porous, large surface area, low-density particles. The process uses industry standard solvents, lung-approved excipients,
a custom-made TFF drum and conventional process equipment.
3
We believe our TFF platform is a breakthrough platform technology for making dry powders from drugs which previously were not candidates for
the dry powder inhaler or any breath-actuated inhaler. We believe our TFF technology opens the way for direct-to-lung delivery of dozens of
pharmaceuticals, including the reformulation of existing drugs into a more safe and convenient inhaled dry powder product. We believe the technology can
be used with molecules of all types and works with existing and off-the-shelf dry powder inhalers without the need for any additional equipment or devices.
We believe our TFF platform presents the following high value opportunities:
● Reformulation of drugs for lung conditions. Today, many drugs intended for lung conditions are only given orally or intravenously due to
properties that make them ill-suited for direct delivery by inhalers. Given by these routes, typically only 10% of the drug reaches the lungs,
and these drugs may cause unwanted and even deadly side effects. We believe that our TFF platform for the first time will allow many of
these medications to be formulated into the convenient, direct-to-lung dry powder inhaler format, thereby enhancing efficacy, reducing or
eliminating side effects and providing for delivery of drug direct to the target site.
● Biologics. Biopharmaceuticals (or biologics) are by far the fastest growing sector in the pharmaceutical industry today. According to
Visiongain, the market for biologics is expected to top $270 billion by 2019. Biologics are most commonly delivered intravenously, and they
can be an especially challenging class of drugs for formulation into a dry powder. We believe our TFF platform is uniquely suited to meet
many of the challenges of biologic formulations, and our UT collaborators have demonstrated, via animal model testing and in vitro testing,
the effectiveness of the TFF technology to produce dry powder biologics with up to 100% activity retained. We intend to explore dry powder
forms of numerous biological drugs, including drugs intended to treat indications other than lung conditions and diseases. We are also
pursuing TFF formulations of salt containing vaccines, which we believe may provide significant advantages over the traditional method of
handling vaccines through liquid suspension and cold chain.
● Combination Drugs. Combination drugs are products with two or more active pharmaceutical ingredients. In addition to providing for
increased patient compliance with multiple medications, some drugs act synergistically and provide for superior benefit when given as a
combination. However, combining pharmaceutical agents can be challenging, especially for inhalation delivery. Our TFF platform has shown
the ability to produce fixed dose combinations of many agents in a manner that delivers the drugs simultaneously to the site of action in a
precise amount.
4
UT initially licensed the TFF technology to The Dow Chemical Company, or Dow, and Dow researchers pursued the development of the TFF
platform until Dow’s decision to divest its pharmaceutical assets in 2007. While at Dow, the technology was scaled from laboratory (milligrams) to
pilot/commercial quantities (kilos). In addition, the Dow team showed that the scaling process did not alter the morphology or other properties of particles
made using TFF. More than a dozen drugs, including both small molecules and biologics, were processed by Dow researchers and UT collaborators using
the technology, and the benefits were quantified using both in vivo and analytical techniques. In a report published by Dow researchers in 2008, they
reported that in several drugs tested by them, there was evidence of enhanced dissolution rates using the TFF platform compared to bulk drugs. In one
instance, the researchers measured that a TFF prepared drug was able to reach 96% dissolution in two minutes compared to 60% dissolution in 30 minutes
by the same drug in bulk form.
Following its decision to divest its pharmaceutical assets in 2007, Dow’s license rights to the TFF platform were terminated. In July 2015, UT
granted to our former parent, LTI, an exclusive worldwide, royalty bearing license to the patent rights for the TFF platform in all fields of use, other than
vaccines, for which LTI was granted a non-exclusive worldwide, royalty bearing license to the patent rights for the TFF platform. In January 2018, we
entered into a Contribution and Subscription Agreement with LTI, pursuant to which we agreed to acquire from LTI certain intellectual property rights and
other assets, including the UT patent license agreement, all of which relate to our TFF platform. We closed on the acquisition of the LTI assets in March
2018. In November 2018, we and UT amended the UT patent license agreement pursuant to which, among other things, our exclusive patent rights to the
TFF platform were expanded to all fields of use.
We continue to work with the inventors of the TFF platform through a series of Sponsored Research Agreements, or SRAs, with UT. Our SRAs
with UT are industry standard sponsored research agreements pursuant to which UT provides to us certain product formulation, characterization and
evaluation services with regard to our product candidates incorporating our TFF technology in exchange for our payment of UT’s expenses and reasonable
overhead. The services conducted by UT are to be carried out under the direction of a principal investigator at UT who is the principal inventor of the TFF
technology. The current SRA expires in April 2022 and is subject to renewal upon mutual agreement of the parties. The SRAs includes customary
provisions concerning confidentiality, indemnification and intellectual property rights, including each party’s exclusive ownership of all intellectual
property developed solely by them and the parties’ joint ownership of all intellectual property developed jointly. All patented intellectual property rights
relating to the TFF technology developed solely or jointly by UT are subject to our patent license agreement with UT and are included among our licensed
patent rights. Pursuant to those SRAs, the research scientists, together with their labs and collaborators, provide expertise and initial development work,
including:
● the preliminary development and in vitro evaluation of our drug candidates;
● the determination of the key characteristics influencing performance of our product candidates;
● the determination of the formulation and manufacturing parameters that influence the key characteristics of our product candidates;
● supply of bulk dry powders for initial good laboratory practice, or GLP, and non-GLP toxicity studies;
● supportive stability for future GLP and GMP studies; and
● the evaluation of the in vivo performance of our product candidates in various animal models.
We have entered into short-term contract manufacturing agreements with IriSys, Inc. and CoreRx, Inc. for their provision of certain product
testing, development and preclinical and clinical manufacturing services for our TFF VIP and TFF TIP product candidates, respectively. Our agreements
with IriSys and CoreRx include customary provisions concerning confidentiality, indemnification and intellectual property rights, including our exclusive
ownership of all intellectual property developed severally or jointly relating to our TFF technology. We have not entered into agreements with any contract
manufacturers for the commercial supply, however, we believe that both IriSys and CoreRx, among several other manufacturers, have the experience and
the capacity to serve as a commercial contract manufacturer. We believe we will be able to engage a commercial contract manufacturer for our product
candidates in a timely manner at competitive pricing.
5
Each of CoreRx’s and IriSys’ facilities and services are conducted in accordance with the FDA’s current good manufacturing practices, or cGMPs,
regulations, and IriSys and CoreRx are in the process of onboarding the TFF technology to support preclinical and clinical supply of our TFF VIP and TFF
TIP drug product candidates, respectively.
Pursuant to the agreements with CoreRx and IriSys, they will generate clinical supplies and provide release and stability testing of the respective
TFF drug product candidate. Specific tasks will include:
● Engineering review and TFF technology installation;
● Familiarization with TFF technology, including powder processing and handling;
● Analytical method transfer, development, and validation;
● Conducting process development trials and short-term supportive stability analysis;
● Scale-up and demonstration batches of the product candidate;
● Manufacture and analytical characterization of materials to support toxicology studies, both, placebo and active;
● Process train qualification for cGMP manufacturing;
● Manufacturing and release of cGMP batches for clinical trials; and
● Conducting formal stability study under the guidelines of International Council for Harmonisation of Technical Requirements for
Pharmaceuticals for Human Use, or ICH.
Because our dry powder drug candidates will represent a new formulation of an existing drug, we will need to obtain FDA approval of the TFF
prepared drug candidate before we can begin commercialization. However, because we begin our formulation with a drug that has previously received FDA
approval in another form, we believe that in most cases we should qualify for the FDA’s 505(b)(2) regulatory pathway, which potentially will take less time
and investment than the standard FDA approval process.
Our Initial Drug Targets
We intend to initially focus on the development of inhaled dry powder drugs for the treatment of pulmonary diseases and conditions. Our dry
powder drug product candidates will be designed for use with dry powder inhalers, which are generally considered to be the most effective of all breath-
actuated inhalers. We intend to develop dry powder drugs that can be used with existing dry powder inhalers that are commercially available without
licensing. We plan to focus on developing dry powder drugs intended for lung diseases and conditions that are off-patent, which we believe includes dozens
of potential drug candidates, many of which have a potential market ranging from $100 million to over $1 billion. As of the date of this report, we have
identified and are focusing on three initial drug candidates and with each we are in the early stages of formulation and testing.
6
TFF Voriconazole Inhalation Powder, VIP – For the Treatment of Invasive Pulmonary Aspergillosis
We are developing an inhaled dry powder drug intended to treat invasive pulmonary aspergillosis, or IPA, a severe fungal pulmonary disease with
a mortality rate that can reach 90% in some patient populations. IPA occurs primarily in patients with severe immunodeficiency, such as bone marrow
transplant recipients, other transplant patients, patients with chemotherapy-induced immunodeficiency, and HIV patients. To date, the antifungals used to
treat IPA have been delivered orally or intravenously. However, these delivery methods have resulted in low drug concentrations in the lung due to poor
bioavailability. We believe these antifungals have serious side effects and drug interaction issues, which places a premium on any solution that can provide
effective treatment in more limited dosages. Due to the nature of these drugs, it has not been possible to make formulations for breath-actuated inhalers that
might maximize lung concentration while limiting side effects.
We believe, and our preclinical studies and clinical trials to date confirm, that our TFF platform can be used to formulate a dry powder version of
Voriconazole, generally considered to be one of the best antifungal drugs used in the treatment of IPA. Voriconazole is an off-patent drug and our TFF
prepared version of Voriconazole would represent the first inhaled antifungal medication for the treatment of IPA, which has the potential to put the drug
exactly where it is needed while minimizing off target effects.
Voriconazole is currently marketed in Australia, Europe and the U.S. as Vfend, and is available in several strengths and presentations for oral
delivery or IV infusion. As of the date of this report, the Clinical Practice Guidelines released by the Infectious Diseases Society of America recommend
Voriconazole as first-line monotherapy for IPA. However, since the registration of Vfend in Europe and the U.S. in 2002, several studies have examined the
exposure-response relationship with Voriconazole, identifying a relationship between low Voriconazole exposure and higher rates of treatment failure, as
well as a higher propensity for neurotoxicity at higher exposures. Studies have shown that when delivered orally or intravenously Voriconazole can have
differing bioavailability, and therefore differing concentration of the drug available to the lungs, based on whether the patient recently had food. In addition,
Voriconazole when delivered orally or intravenously has been shown to have various side effects including nausea and headaches, and adverse events
including optic neuritis and papilledema, hepatic toxicity, galactose intolerance, arrhythmias and QT prolongation. These studies confirm that when
administered orally or intravenously, Voriconazole provides a narrow therapeutic window between treatment failure and unacceptable treatment toxicity.
We believe a TFF prepared dry powder formulation of Voriconazole can maximize both the prophylactic value to the lungs for
immunocompromised patients susceptible to IPA and the treatment value of patients suffering from chronic IPA. We also believe our dry powder drug
would benefit patients by providing the drug at the “port of entry” of invasive fungal infections, while also reducing or eliminating the unpleasant and
potentially fatal side effects associated with Voriconazole and other last line antifungals. We also believe that the administration of our TFF prepared dry
powder formulation directly to the lungs will significantly reduce any potential differences in bioavailability due to the effects of eating or fasting. In
addition, animal and in vitro studies have shown that our TFF prepared dry powder formulation will improve the solubility of Voriconazole compared to
oral or intravenous delivery. We believe that the combination of improved solubility and direct-to-lung administration of our TFF prepared dry powder
formulation will allow for a lower dose directly to the lungs and thereby reduce the high systemic exposure of oral administration and associated side
effects, including optic neuritis and papilledema, hepatic toxicity, galactose intolerance, arrhythmias and QT prolongation.
Through our work with UT, we successfully conducted preclinical testing of a TFF formulation of Voriconazole in 2018.
In February 2019, we participated in a pre-IND meeting with the FDA for purposes of discussing our proposed regulatory pathway for TFF VIP
and obtaining guidance from the FDA on the pre-clinical plan leading to the filing and acceptance of an IND application for TFF VIP. We were successful
in gaining agreement that a 505(b)(2) approach would be appropriate for TFF VIP. In October 2019, we submitted to the FDA an IND for our TFF VIP and
initiated our Phase I human clinical trials in November 2019. We completed the clinical portion of our Phase 1 trial in July 2020 and progressed to a Phase
1b clinical trial in asthma patients in November 2020. We believe that subject to a successful completion of a well-controlled and adequately powered
Phase II study, we will be able to file FDA marketing approval. However, there can be no assurance that the FDA will not ask for additional clinical data.
We also believe that our dry powder formulation may qualify as an orphan drug, as there are an estimated 50,000 transplants in the U.S. each year that are
at risk of developing IPA as well as approximately 50,000 patients suffering with IPA.
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TFF Tacrolimus Inhalation Powder, TIP — For Immunosuppression to Prevent Organ Transplant Rejection
We are developing TFF TIP, a dry powder version of Tacrolimus, an immunosuppressive drug used in transplant medicine. Prograf Tacrolimus is
currently the second most commonly administered immunosuppressive agent in solid organ transplantation despite what we believe to be the many
challenges for patients and physicians when used for extended periods. Prograf Tacrolimus can cause nephrotoxicity, particularly when used in high doses.
According to product labeling and prescribing information for Prograf Tacrolimus, nephrotoxicity was reported in approximately 52% of kidney
transplantation patients and in 40% and 36% of liver transplantation patients receiving Prograf in the U.S. and European randomized trials, respectively,
and in 59% of heart transplantation patients in a European randomized trial.
Although Tacrolimus has been shown via animal models to be beneficial for a number of immunological diseases that affect the lung, systemic
toxicity (including renal failure, hypertension, hirsutism, diabetes) has limited its use. In addition, Tacrolimus when delivered orally or intravenously has
been shown to have side effects including nausea, indigestion, stomach pain and headaches. Adverse events associated with Tacrolimus when delivered
orally or intravenously include increase in cancer, increase in infections, anemia, kidney problems, nervous system problems (including seizures, coma,
tremors, confusion, headaches), high blood pressure, QT prolongation, high level of potassium in the blood, myocardial hypertrophy, diabetes, damage to
the brain, high level of fats or lipids or phosphates in the blood, constipation, diarrhea, bronchitis, inability to sleep, low magnesium levels, reduction in
white blood cells, lack of energy, damage to the peripheral nerves, and fluid around the heart.
Tacrolimus is an off-patent drug and we intend to develop a dry powder version suitable for use with a dry powder inhaler. Because our dry
powder version would provide for a high local lung concentration without the typical systemic toxicity frequently experienced with oral dosage form
immunosuppressants, we believe our drug candidate should have a high likelihood of success in competing in the immunosuppressant market for lung and
heart/lung transplants.
Through our partners at UT, we successfully conducted preclinical testing of our dry powder formulation of Tacrolimus in 2018.
In September 2019, we participated in a pre-IND meeting with the FDA for purposes of discussing our proposed regulatory pathway for TFF TIP
and obtaining guidance from the FDA on the pre-clinical plan leading to the filing and acceptance of an IND application for TFF TIP. We were successful
in gaining agreement that a 505(b)(2) approach would be appropriate for TFF TIP. We are conducting Phase I clinical trials for our TFF formulation of
Tacrolimus in Australia, which we consider to be a highly desirable site to conduct human clinical trials. On March 13, 2020, we received the approval of
the Alfred Hospital Human Research Ethics Committee to commence Phase I trials in Melbourne, Victoria, Australia. However, later in March 2020, our
contract research organization partner in Australia informed us that due to the spread of the COVID-19 virus in Australia, there would be a delay in
initiating the trial. One contributing factor is that Tacrolimus is an immunosuppressant drug and, given the threat of the COVID-19 virus, we were
concerned that even though we would be dosing healthy volunteers the inhalation of an immunosuppressant could increase the risk of severe complications
if a volunteer was to contract COVID-19. In June 2020, we were able to begin dosing in the Phase I trial our TFF TIP in Melbourne, however, in July 2020,
due to the resurgence of COVID-19 in the Melbourne area, the Phase I trials were delayed. With the flaring of COVID-19 in the Melbourne area and in
order to remain dynamic, a second clinical trial site in Brisbane, Queensland, Australia was opened and we resumed dosing in the Phase I clinical trials
during the third quarter of 2020. As of the date of this report, we intend to submit to the FDA an IND for TFF TIP when we initiate Phase 2 clinical trials.
Triple Combination For COPD/Asthma
We are developing a dry powder drug combination intended to treat chronic obstructive pulmonary disease, or COPD, and asthma. There is a trend
towards a three-drug combination in the treatment of uncontrolled COPD and asthma. Data suggests that therapy with a long-acting antimuscarinic agent,
or LAMA, a long-acting β2-agonist, or LABA, and an inhaled corticosteroid, or ICS, is effective in patients with severe COPD. GSK has received FDA
approval for a triple combination drug, Trelegy Ellipta, for the treatment of pulmonary disease. In addition, a variety of triple combinations are currently
under development by large pharmaceutical companies, including AstraZeneca and Chiesi Farmaceutici.
We are currently pursuing the development of a combination dry powder drug intended for use with a dry powder inhaler for the maintenance
treatment of bronchospasm associated with moderate to severe COPD. Unlike most other triple combinations, which are chosen in part from the
pharmaceutical company’s list of existing products, our triple combination drug contains what we consider will be the best-in-class drug in each category of
LAMA, LABA and ICS.
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Each of the drugs in our proposed dry powder triple combination is currently off-patent and each is available for delivery individually by way of
breath-actuated inhalers. However, the three drugs in combination are not available for delivery through any breath-actuated inhalers due to the inability to
deliver the drugs through the airway in the exact ratio designed for treatment. We believe, however, that our TFF platform allows for all three drugs to end
up in each particle delivered to the airway in the exact ratio designed for treatment.
Since competition exists, and typically large clinical trials are needed to approve this type of triple combination drug, our strategy would be to
develop the triple combination dry powder drug in partnership with a large pharmaceutical company looking to compete in the COPD and asthma markets.
We intend to engage large pharmaceutical companies in discussions concerning a potential joint development of our triple combination dry powder drug.
However, as of the date of this report we have no agreements, understandings or arrangements concerning a joint development program and there can be no
assurance we will be able to enter into a joint development agreement on terms acceptable to us. We do not intend to pursue the development of our triple
combination dry powder drug beyond performance characterization and efficacy data through early animal testing until such time, if ever, as we obtain a
development partner.
Other Potential Dry Powder Products
Our business model is to develop proprietary innovative drug product candidates that offer commercial or functional advantages, or both, to
currently available alternatives. In our initial evaluation of the market, we have identified a number of potential drug candidates that show promise upon
initial assessment, for two of which we have conducted meaningful development activities, including dry powder formulations of:
● Inhaled SARS-CoV2 Monoclonal Antibody (Joint development with Augmenta BioWorks), is an inhaled powder form of a novel
neutralizing monoclonal antibody (mAb) produced using the proprietary TFF process. The proprietary mAb in this formulation was identified
by Augmenta BioWorks and has demonstrated potent binding and neutralization activity against the SARS-CoV2 virus that causes the
COVID-19 disease. Recent Emergency Use Authorizations of anti-SARS-CoV2-mAbs delivered by intravenous infusion have been achieved
by Regeneron and Eli Lilly. Early testing confirmed that our TFF platform can be used to formulate a dry powder mAb for inhalation delivery.
We believe a TFF prepared anti-SARS-CoV2-mAb administered directly to the lungs can maximize the early outpatient treatment of patients
with COVID-19 infections who are at risk for serious disease complications while minimizing the amount of antibody required to achieve
efficacious doses.
● Niclosamide Inhalation Powder is an inhaled dry powder formulation of Niclosamide produced using the proprietary TFF process.
Niclosamide has been used to treat tapeworm infections in humans since the 1960s and was recently reported to be one of the most potent
approved drugs in screens for antiviral activity against the SARS-CoV2 virus that causes the COVID-19 disease. Early testing confirmed that
our TFF platform can be used to formulate a dry powder version of Niclosamide, which is no longer subject to patent protection. We believe a
TFF prepared dry powder formulation of Niclosamide administered directly to the lungs can maximize both the early outpatient treatment of
patients with COVID-19 infections who are at risk for serious disease complications and for prophylactic use for persons exposed to COVID-
19. TFF has also obtained the rights to a novel formulation that may enhance the bioavailability of Niclosamide through oral delivery under
our license from the University of Texas. Systemically delivered Niclosamide has shown promise for the treatment of COVID -19 and various
forms of cancer.
●
Cannabidiol, or CBD, a controlled substance as defined in the federal Controlled Substances Act of 1970, or CSA, that is reported to be used
by some for the treatment of various epilepsy syndromes as well as anxiety, insomnia, and different types of pain. We are in the early stages of
developing an inhaled dry powder drug that could be used to support or to treat a variety of health issues that may benefit from CBD
administration. Researchers have explored using the broader class of cannabinoids for inflammation, symptoms of multiple sclerosis,
anorexia, schizophrenia, and other conditions. The FDA has approved Epidiolex for the treatment of seizures associated with Lennox-Gastaut
syndrome or Dravet syndrome in patients two years of age or older. The Epidiolex product is an oral solution containing 100 mg/mL of CBD.
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We believe, and early in-vitro research confirms, that our TFF platform can be used to formulate a dry powder version of CBD. Through our
work with UT, early animal model testing of TFF formulations of CBD administered via inhalation have been completed. The inhaled CBD
showed more sustained pharmacokinetic blood levels compared to the IV delivery method in the animal studies.
We intend to engage pharmaceutical and non-pharmaceutical companies in the CBD space in discussions concerning a potential joint
development of our dry powder formulation of CBD, which may target a CBD drug product subject to FDA regulation or a non-drug CBD
product that may not be subject to FDA approval. We do not intend to pursue the development of our dry powder formulation of a CBD drug
product beyond performance characterization and efficacy data through early animal testing until such time, if ever, as we obtain a drug
development partner. There can be no assurance that our early testing and development will lead to a commercial dry powder formulation of a
CBD drug product.
The 2018 Farm Bill, which was signed into law on December 20, 2018, liberalized to some degree the regulation of hemp and hemp-derived
products, such as CBDs, under the CSA. However, the 2018 Farm Bill did not alter the FDA’s authority to regulate products containing
cannabis or cannabis-derived compounds, including CBD, under the Federal Food, Drug, and Cosmetic Act, or the FDCA. Following passage
of the 2018 Farm Bill, the FDA reaffirmed its enforcement authority and reiterated the requirement that a CBD product (hemp-derived or
otherwise) that is marketed with a claim of therapeutic benefit, or with any other disease claim, be approved by the FDA for its intended use
before it may be introduced into interstate commerce. However, we believe that CBD products that are not marketed with a claim of
therapeutic benefit, or with any other disease claim, and meet the requirements of a dietary supplement, may not require FDA pre-marketing
approval. Hemp products, including CBDs, that qualify as drugs, food, dietary supplements, veterinary products, and cosmetics will continue
to be regulated by the FDA under the applicable regulatory frameworks. As of the date of this report, we believe that Epidiolex is the only
CBD-based product that has received market approval from the FDA.
● Vaccines containing aluminum salts, which make up approximately 35% of all vaccines. Aluminum salts are incorporated into many vaccine
formulations as an adjuvant, which is a substance added to vaccines to enhance the immune response of vaccinated individuals. A major
limitation with these vaccines is that they are very fragile and to maintain their efficacy they must be formulated as liquid suspensions and
kept in a cold chain (2–8°C) during transport and storage, which is burdensome and expensive. Also, exposure of the liquid vaccines to either
ambient or freezing temperatures will cause a loss of efficacy, including particle aggregation in the case of freezing. Alternatives to cold chain
have been examined, including the introduction of stabilizing agents in vaccines to prevent aggregation during freezing and the application of
novel freezing and drying techniques; however, we believe that to date none of these techniques have led to an acceptable alternative to cold
chain.
We have conducted drug and performance characterization activities of certain TFF formulated salt containing vaccines. Our activities suggest
that the salt containing vaccines can be successfully converted from liquid suspension into dry powder using our TFF platform using a
relatively low concentration of trehalose as an excipient, and that the dry powder can later be reconstituted at the time of use without causing
particle aggregation or decrease in efficacy. In addition, the dry vaccine powder did not aggregate after repeated dry-freezing-and-thawing.
We believe that the TFF platform may be used to formulate new vaccines, or to reformulate existing vaccines, that are adjuvanted with
aluminum salts into dry vaccine powder without significant loss of efficacy.
We intend to engage pharmaceutical companies in the vaccine space in discussions concerning a potential joint development of TFF
formulated salt containing vaccines and, in the meantime, we do not intend to pursue the development of our dry powder formulation of salt
containing vaccines beyond performance characterization and efficacy data through early animal testing until such time, if ever, as we obtain
a development partner. There can be no assurance, however, that our early testing and development will lead to a commercial dry powder
formulation of salt containing vaccines.
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We have identified a number of additional drug candidates that show promise upon initial evaluation. In each case, these are drugs for which we
would directly pursue the development of a dry powder formulation for use through a dry powder inhaler. We have not commenced meaningful
development activities for any of these product candidates at this time and there can be no assurance that we will pursue any of the product candidates
below.
Candidate
Rapamycin
Alpha-1-antitrypsin
GM-CSF (filgrastim)
Treprostinil
Pembrolizumab (Keytruda)
Cisplatin
Gemcitabine
Isoniazid/Rifampicin
Amphotericin B
Palivizumab
Ciprofloxacin
Tobramycin
Azithromycin
Calcium channel blockers
Sumatriptin
Stem cells
Intervention
Indication
Acute Treatment
Chronic Treatment
Treatment
Treatment
Acute Treatment
Acute Treatment
Acute Treatment
Acute Treatment
Acute Treatment
Prophylaxis
Acute Treatment
Acute Treatment
Acute Treatment
Acute Treatment
Acute Treatment
Lung remodeling
Lymphangioleiomyomatosis
Vitamin A deficiency
Autoimmune pulmonary alveolar proteinosis
Pulmonary Arterial Hypertension
Cancer: Non–Small Cell Lung Cancer, Liver, brain, melanoma, metastatic
Lung or esophageal cancer
Lung or esophageal cancer
Tuberculosis
Antifungal
Tuberculosis
Infection
Infection
Infection
Raynaud’s disease
Migraine
Pneumococcal pneumonia; cardiomyopathy
We believe that our TFF technology provides a very diverse and effective way to develop solutions for lung specific disorders. Many potentially
beneficial drugs for lung diseases and disorders are unable to be dosed in high enough concentration to provide therapeutic benefit to the lung due to the
systemic nature (oral or IV dosing) of the drug leading to toxicity of the kidney, lungs and other systemic safety concerns. We believe our TFF platform has
the potential to take these difficult to formulate drugs and develop products to be delivered directly to the lung for treatment of lung diseases and disorders.
This direct dosing may reduce plasma levels and has the potential to increase efficacy while reducing side effects.
We believe that all of the above potential drug candidates are off-patent drugs for which we would directly pursue the development of a dry
powder formulation through the FDA’s 505(b)(2) regulatory pathway. However, not all of our drug product candidates will target off-patent drugs. For
example, we do not expect our proposed dry powder formulation of CBD to be off-patent and our proposed dry powder formulation of aluminum salt
vaccines may not be off-patent. We also expect that our dry powder formulation of a CBD drug product will likely require a full NDA through the FDA’s
505(b)(1) regulatory pathway and that our dry powder formulation of aluminum salt vaccines will require a biological license application, or BLA, which is
very similar to a full NDA through the FDA’s 505(b)(1) regulatory pathway.
Licenses and Intellectual Property Rights
We hold rights to our TFF technology pursuant to a patent license agreement entered into in July 2015, between University of Texas at Austin, or
UT, and our former parent, LTI, which LTI assigned to us in March 2018, as amended by UT and us on November 30, 2018. UT is the owner of 42 U.S.
and international patents and patent applications with claims covering the TFF platform. Pursuant to the amended patent license agreement, we hold an
exclusive worldwide, royalty bearing license to the rights to the aforementioned patents, including any divisionals, continuations and extensions, in all
fields of use.
We are required to pay royalties to UT in the amount of 2% of net sales received by us from the sale of products covered by the licensed patent
rights. We will also be required to make certain milestone payments to UT in connection with the certain regulatory submissions and approvals and pay
fees in connection with any assignments or sublicenses, including:
● $50,000 upon each approval of an IND for the first indication of each product candidate;
● $100,000 upon submission of a final Phase II report (or a foreign equivalent) on the first product candidate;
● $250,000 upon submission of a final Phase III report (or a foreign equivalent) on the first product candidate;
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● $500,000 upon regulatory approval in the U.S. (or a foreign equivalent) on the first product candidate;
● $500,000 upon regulatory approval in the U.S. (or a foreign equivalent) on the second product candidate or on the second indication of the
first product candidate; and
● Our issuance to UT of one percent (1%) of our outstanding common stock, calculated on a fully-diluted basis, upon and as of our first IND
approval for a product candidate.
Pursuant to the UT patent license agreement, UT has agreed to consult with us concerning the development and implementation of a strategy for
the prosecution and maintenance of the licensed patent rights, including any infringement of the licensed patents rights by third-parties. However, UT has
retained control and final decision-making authority over such matters. We are responsible for the payment of all fees and expenses involved in the
prosecution and maintenance of the licensed patent rights and are obligated to negotiate in good faith with UT over the funding and allocation of any
recovery involved in any patent infringement action brought to enforce the licensed patent rights, which are presently scheduled to expire over a period of
time commencing in 2023 and ending in 2035. The term of the UT patent license agreement is co-terminus with the licensed patent rights. However, UT
has the right to terminate the patent license agreement, or any part of the licensed patent rights or field of use, in the event of our breach of any provision of
the patent license agreement that remains uncured after UT’s written notice of breach and an applicable cure period or in the event we initiate any
proceeding to challenge the validity or scope of the licensed patent rights. The agreement also contains customary representations, warranties, covenants
and indemnities by the parties.
In addition to the licensed patent rights, we also rely on our trade secrets, know-how and continuing technological innovation to develop and
maintain our proprietary position. We will vigorously defend our intellectual property to preserve our rights and gain the benefit of our technological
investments.
Government Regulations and Funding
Pharmaceutical companies are subject to extensive regulation by foreign, federal, state and local agencies, such as the U.S. FDA, and various
similar agencies in most countries worldwide. The manufacture, distribution, marketing and sale of pharmaceutical products are subject to government
regulation in the U.S. and various foreign countries. Additionally, in the U.S., we must follow rules and regulations established by the FDA requiring the
presentation of data indicating that our product candidates are safe and efficacious and are manufactured in accordance with cGMP regulations. If we do
not comply with applicable requirements, we may be fined, the government may refuse to approve our marketing applications or allow us to manufacture
or market our product candidates, and we may be criminally prosecuted. We, our manufacturers and clinical research organizations, may also be subject to
regulations under other foreign, federal, state and local laws, including, but not limited to, the U.S. Occupational Safety and Health Act, the Resource
Conservation and Recovery Act, the Clean Air Act and import, export and customs regulations as well as the laws and regulations of other countries. The
U.S. government has increased its enforcement activity regarding illegal marketing practices domestically and internationally. As a result, pharmaceutical
companies must ensure their compliance with the Foreign Corrupt Practices Act and federal healthcare fraud and abuse laws, including the False Claims
Act.
These regulatory requirements impact our operations and differ from one country to another, so that securing the applicable regulatory approvals
of one country does not imply the approval of another country. The approval procedures involve high costs and are manpower intensive, usually extend
over many years and require highly skilled and professional resources.
FDA Market Approval Process
The steps usually required to be taken before a new drug may be marketed in the U.S. generally include:
● completion of pre-clinical laboratory and animal testing;
● completion of required chemistry, manufacturing and controls testing;
● the submission to the FDA of an IND, which must be evaluated and found acceptable by the FDA before human clinical trials may
commence;
● performance of adequate and well-controlled human clinical trials to establish the safety, pharmacokinetics and efficacy of the proposed drug
for its intended use;
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● submission and approval of an NDA;
● successful pre-approval inspection of the manufacturer and analytical testing facilities; and
● agreement with FDA of the label language, including the prescribing information insert.
Clinical studies are conducted under protocols detailing, among other things, the objectives of the study, what types of patients may enter the
study, schedules of tests and procedures, drugs, dosages, and length of study, as well as the parameters to be used in monitoring safety, and the efficacy
criteria to be evaluated. A protocol for each clinical study and any subsequent protocol amendments must be submitted to the FDA as part of the IND
process.
Clinical trials are usually conducted in three phases. Phase I clinical trials are normally conducted in small groups of healthy volunteers to assess
safety and tolerability of various dosing regimens and pharmacokinetics. After a safe dose has been established, in Phase II clinical trials the drug is
administered to small populations of sick patients to look for initial signs of efficacy via dose ranging studies in treating the targeted disease or condition
and to continue to assess safety and the effective doses to be studied in larger trials in Phase III. In the case of vaccines, the participants are healthy and the
signs of efficacy can be obtained in early Phase I, therefore this Phase is defined as Phase I/II. Phase III clinical trials are usually multi-center, double-blind
controlled trials in hundreds or even thousands of subjects at various sites to assess as fully as possible both the safety and effectiveness of the drug.
Clinical trials must be conducted in accordance with the FDA’s good clinical practice, or GCP, requirements. The FDA may order the temporary or
permanent discontinuation of a clinical study at any time or impose other sanctions if it believes that the clinical study is not being conducted in accordance
with FDA requirements or that the participants are being exposed to an unacceptable health risk. An institutional review board, or IRB, generally must
approve the clinical trial design and patient informed consent at study sites that the IRB oversees and also may halt a study, either temporarily or
permanently, for failure to comply with the IRB’s requirements, or may impose other conditions. Additionally, some clinical studies are overseen by an
independent group of qualified experts organized by the clinical study sponsor, known as a data safety monitoring board or committee. This group
recommends whether or not a trial may move forward at designated check points based on access to certain data from the study. The clinical study sponsor
may also suspend or terminate a clinical trial based on evolving business objectives and/or competitive climate.
As a product candidate moves through the clinical testing phases, manufacturing processes are further defined, refined, controlled and validated.
The level of control and validation required by the FDA increases as clinical studies progress. We and the third-party manufacturers on which we rely for
the manufacture of our product candidates and their respective components (including the API) are subject to requirements that drugs be manufactured,
packaged and labeled in conformity with cGMPs. To comply with cGMP requirements, manufacturers must continue to spend time, money and effort to
meet requirements relating to personnel, facilities, equipment, production and process, labeling and packaging, quality control, recordkeeping and other
requirements.
Assuming completion of all required testing in accordance with all applicable regulatory requirements, detailed information on the product
candidate is submitted to the FDA in the form of an NDA, requesting approval to market the product for one or more indications, together with payment of
a user fee, unless waived. An NDA includes all relevant data available from pertinent nonclinical and clinical studies, including negative or ambiguous
results as well as positive findings, together with detailed information on the chemistry, manufacture, controls and proposed labeling, among other things.
To support marketing approval, the data submitted must be sufficient in quality and quantity to establish the safety and efficacy of the product candidate for
its intended use to the satisfaction of the FDA. The FDA also conducts a pre-approval inspection of the manufacturer and laboratory prior to approval of the
NDA.
If an NDA submission is accepted for filing, the FDA begins an in-depth review of the NDA. Under the Prescription Drug User Fee Act, or
PDUFA, the FDA’s goal is to complete its initial review and respond to the applicant within ten months of submission, unless the application relates to an
unmet medical need, or is for a serious or life-threatening indication, in which case the goal may be within six months of NDA submission. However,
PDUFA goal dates are not legal mandates and the FDA response often occurs several months beyond the original PDUFA goal date. Further, the review
process and the target response date under PDUFA may be extended if the FDA requests or the NDA sponsor otherwise provides additional information or
clarification regarding information already provided in the NDA. The NDA review process can, accordingly, be very lengthy. During its review of an NDA,
the FDA may refer the application to an advisory committee for review, evaluation and recommendation as to whether the application should be approved.
The FDA is not bound by the recommendation of an advisory committee, but it typically follows such recommendations. Data from clinical studies are not
always conclusive and the FDA and/or any advisory committee it appoints may interpret data differently than the applicant.
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After the FDA evaluates the NDA and inspects manufacturing facilities where the drug product and/or its API will be produced and tested, it will
either approve commercial marketing of the drug product with prescribing information for specific indications or issue a complete response letter indicating
that the application is not ready for approval and stating the conditions that must be met in order to secure approval of the NDA. If the complete response
letter requires additional data and the applicant subsequently submits that data, the FDA nevertheless may ultimately decide that the NDA does not satisfy
its criteria for approval. The FDA could also approve the NDA with a Risk Evaluation and Mitigation Strategies, or REMS, plan to mitigate risks, which
could include medication guides, physician communication plans, or elements to assure safe use, such as restricted distribution methods, patient registries
and other risk minimization tools. The FDA also may condition approval on, among other things, changes to proposed labeling, development of adequate
controls and specifications, or a commitment to conduct post-marketing testing. Such post-marketing testing may include Phase IV clinical trials and
surveillance to further assess and monitor the product’s safety and efficacy after approval. Regulatory approval of products for serious or life-threatening
indications may require that participants in clinical studies be followed for long periods to determine the overall survival benefit of the drug.
If the FDA approves one of our product candidates, we will be required to comply with a number of post-approval regulatory requirements. We
would be required to report, among other things, certain adverse reactions and production problems to the FDA, provide updated safety and efficacy
information and comply with requirements concerning advertising and promotional labeling for any of our product candidates. Also, quality control and
manufacturing procedures must continue to conform to cGMPs after approval, and the FDA periodically inspects manufacturing facilities to assess
compliance with cGMPs, which imposes extensive procedural, substantive and record keeping requirements. If we seek to make certain changes to an
approved product, such as certain manufacturing changes, we may need FDA review and approval before the change can be implemented.
While physicians may use products for indications that have not been approved by the FDA, we may not label or promote the product for an
indication that has not been approved. Securing FDA approval for new indications is similar to the process for approval of the original indication and
requires, among other things, submitting data from adequate and well-controlled studies that demonstrate the product’s safety and efficacy in the new
indication. Even if such studies are conducted, the FDA may not approve any change in a timely fashion, or at all.
The FDA may also require post-marketing testing, or Phase IV testing, as well as risk minimization action plans and surveillance to monitor the
effects of an approved product or place conditions or an approval that could otherwise restrict the distribution or use of the product.
Section 505(b)(2) New Drug Applications
We intend to submit applications for both of our lead therapeutic candidates via the 505(b)(2) regulatory pathway. As an alternate path for FDA
approval of new indications or new formulations of previously-approved products, a company may file a Section 505(b)(2) NDA, instead of a “stand-
alone” or “full” NDA. Section 505(b)(2) of the FDCA was enacted as part of the Drug Price Competition and Patent Term Restoration Act of 1984,
otherwise known as the Hatch-Waxman Amendments. Section 505(b)(2) permits the submission of an NDA where at least some of the information
required for approval comes from studies not conducted by or for the applicant and for which the applicant has not obtained a right of reference. Some
examples of products that may be allowed to follow a 505(b)(2) path to approval are drugs that have a new dosage form, strength, route of administration,
formulation or indication.
The Hatch-Waxman Amendments permit the applicant to rely upon certain published nonclinical or clinical studies conducted for an approved
product or the FDA’s conclusions from prior review of such studies. The FDA may require companies to perform additional studies or measurements to
support any changes from the approved product. The FDA may then approve the new product for all or some of the labeled indications for which the
reference product has been approved, as well as for any new indication supported by the Section 505(b)(2) application. While references to nonclinical and
clinical data not generated by the applicant or for which the applicant does not have a right of reference are allowed, all development, process, stability,
qualification and validation data related to the manufacturing and quality of the new product must be included in an NDA submitted under Section 505(b)
(2).
To the extent that the Section 505(b)(2) applicant is relying on the FDA’s conclusions regarding studies conducted for an already approved
product, the applicant is required to certify to the FDA concerning any patents listed for the approved product in the FDA’s Approved Drug Products with
Therapeutic Equivalence Evaluations, or Orange Book. Specifically, the applicant must certify that: (i) the required patent information has not been filed;
(ii) the listed patent has expired; (iii) the listed patent has not expired, but will expire on a particular date and approval is sought after patent expiration; or
(iv) the listed patent is invalid or will not be infringed by the new product. The Section 505(b)(2) application also will not be approved until any non-patent
exclusivity, such as exclusivity for obtaining approval of a new chemical entity, listed in the Orange Book for the reference product has expired. If the
Orange Book certifications outlined above are not accomplished, the Section 505(b)(2) applicant may invest a significant amount of time and expense in
the development of its products only to be subject to significant delay and patent litigation before its products may be commercialized.
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Orphan Drugs
Under the Orphan Drug Act, the FDA may grant orphan designation to a drug intended to treat a rare disease or condition affecting fewer than
200,000 individuals in the United States, or in other limited cases. Orphan drug designation (ODD) provides for seven years of market exclusivity,
independent of patent protection, to the company with ODD that brings a particular product to market. In addition, companies developing orphan drugs are
eligible for certain incentives, including tax credits for qualified clinical testing. In addition, an NDA for a product that has received orphan drug
designation is not subject to a prescription drug user fee unless the application includes an indication other than the rare disease or condition for which the
drug was designated.
To gain exclusivity, if a product that has orphan drug designation subsequently receives the first FDA approval for the disease or condition for
which it has such designation, the product is entitled to the orphan drug exclusivity, which means that the FDA may not approve any other applications to
market the same active moiety for the same indication for seven years, except in limited circumstances, such as another drug’s showing of clinical
superiority over the drug with orphan exclusivity. Competitors, however, may receive approval of different active moieties for the same indication or obtain
approval for the same active moiety for a different indication. In addition, doctors may prescribe products for off-label uses and undermine our exclusivity.
Orphan drug exclusivity could block the approval of one of our product candidates for seven years if a competitor obtains approval for the same active
moiety for the same indication before we do, unless we are able to demonstrate that our product is clinically superior.
We may plan to pursue orphan drug designation and exclusivity for some of our product candidates in the United States, European Union, and
other geographies of interest for specific products. We cannot guarantee that we will obtain orphan drug designation for any products in any jurisdiction.
Even if we are able to obtain orphan drug designation for a product, we cannot be sure that such product will be approved, that we will be able to obtain
orphan drug exclusivity upon approval, if ever, or that we will be able to maintain any exclusivity that is granted.
Continuing Regulation
After a drug is approved for marketing and enters the marketplace, numerous regulatory requirements continue to apply. These include, but are not
limited to:
● the FDA’s cGMP regulations require manufacturers, including third party manufacturers, to follow stringent requirements for the methods,
facilities and controls used in manufacturing, processing and packing of a drug product;
● labeling regulations and the FDA prohibitions against the promotion of drugs for unapproved uses (known as off-label uses), as well as
requirements to provide adequate information on both risks and benefits during promotion of the drug;
● approval of product modifications or use of a drug for an indication other than approved in an NDA;
● adverse drug experience regulations, which require us to report information on adverse events during pre-market testing and post-approval
safety reporting;
● NDA quarterly reporting for the first three years, then annual reporting thereafter, of changes in chemistry, manufacturing and control or
CMC, labeling, clinical studies and findings, and toxicology studies from the data submitted in the NDA;
● post-market testing and surveillance requirements, including Phase IV trials, when necessary to protect the public health or to provide
additional safety and effectiveness data for the drug; and
● the FDA’s recall authority, whereby it can ask, or under certain conditions order, drug manufacturers to recall from the market a product that is
in violation of governing laws and regulation. After a drug receives approval, any modification in conditions of use, active ingredient(s), route
of administration, dosage form, strength or bioavailability, will require a new approval, for which it may be possible to submit a 505(b)(2),
accompanied by additional clinical data necessary to demonstrate the safety and effectiveness of the product with the proposed changes.
Additional clinical studies may be required for proposed changes.
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Other U.S. Healthcare Laws and Compliance Requirements
For products distributed in the United States, we will also be subject to additional healthcare regulation and enforcement by the federal
government and the states in which we conduct our business. Applicable federal and state healthcare laws and regulations include the following:
● The federal healthcare anti-kickback statute prohibits, among other things, persons from knowingly and willfully soliciting, offering,
receiving, or providing remuneration, directly or indirectly, in cash or in kind, to induce or reward either the referral of an individual for, or
the purchase, order, or recommendation of, any good or service, for which payment may be made under federal healthcare programs such as
Medicare and Medicaid;
● The Ethics in Patient Referrals Act, commonly referred to as the Stark Law, and its corresponding regulations, prohibit physicians from
referring patients for designated health services (including outpatient drugs) reimbursed under the Medicare or Medicaid programs to entities
with which the physicians or their immediate family members have a financial relationship or an ownership interest, subject to narrow
regulatory exceptions, and prohibits those entities from submitting claims to Medicare or Medicaid for payment of items or services provided
to a referred beneficiary;
● The federal False Claims Act imposes criminal and civil penalties, including civil whistleblower or qui tam actions, against individuals or
entities for knowingly presenting, or causing to be presented, to the federal government claims for payment that are false or fraudulent or
making a false statement to avoid, decrease, or conceal an obligation to pay money to the federal government;
● Health Insurance Portability and Accountability Act of 1996, imposes criminal and civil liability for executing a scheme to defraud any
healthcare benefit program and also imposes obligations, including mandatory contractual terms, with respect to safeguarding the privacy,
security and transmission of individually identifiable health information. This statute also prohibits knowingly and willfully falsifying,
concealing or covering up a material fact or making any materially false statement in connection with the delivery of or payment for
healthcare benefits, items, or services; and
● Analogous state laws and regulations, such as state anti-kickback and false claims laws, may apply to sales or marketing arrangements and
claims involving healthcare items or services reimbursed by non-governmental third-party payors, including private insurers, and some state
laws require pharmaceutical companies to comply with the pharmaceutical industry’s voluntary compliance guidelines and the relevant
compliance guidance promulgated by the federal government.
Reimbursement
Sales of our product candidates in the United States may depend, in part, on the extent to which the costs of the product candidates will be covered
by third-party payers, such as government health programs, commercial insurance and managed health care organizations. These third-party payers are
increasingly challenging the prices charged for medical products and services. Additionally, the containment of health care costs has become a priority of
federal and state governments, and the prices of drugs have been a focus in this effort. The United States government, state legislatures and foreign
governments have shown significant interest in implementing cost-containment programs, including price controls, restrictions on reimbursement and
requirements for substitution of generic products. Adoption of price controls and cost-containment measures, and adoption of more restrictive policies in
jurisdictions with existing controls and measures, could further limit our net revenue and results. If these third-party payers do not consider our product
candidates to be cost-effective compared to other available therapies, they may not cover our product candidates after approval as a benefit under their
plans or, if they do, the level of payment may not be sufficient to allow us to sell our product candidates on a profitable basis.
The Medicare Prescription Drug, Improvement, and Modernization Act of 2003, or the MMA, imposes new requirements for the distribution and
pricing of prescription drugs for Medicare beneficiaries and includes a major expansion of the prescription drug benefit under Medicare Part D. Under Part
D, Medicare beneficiaries may enroll in prescription drug plans offered by private entities which will provide coverage of outpatient prescription drugs.
Part D plans include both stand-alone prescription drug benefit plans and prescription drug coverage as a supplement to Medicare Advantage plans. Unlike
Medicare Parts A and B, Part D coverage is not standardized. Part D prescription drug plan sponsors are not required to pay for all covered Part D drugs,
and each drug plan can develop its own drug formulary that identifies which drugs it will cover and at what tier or level. However, Part D prescription drug
formularies must include drugs within each therapeutic category and class of covered Part D drugs, though not necessarily all the drugs in each category or
class. Any formulary used by a Part D prescription drug plan must be developed and reviewed by a pharmacy and therapeutic committee. Government
payment for some of the costs of prescription drugs may increase demand for product candidates for which we receive marketing approval. However, any
negotiated prices for our product candidates covered by a Part D prescription drug plan will likely be lower than the prices we might otherwise obtain.
Moreover, while the MMA applies only to drug benefits for Medicare beneficiaries, private payers often follow Medicare coverage policy and payment
limitations in setting their own payment rates. Any reduction in payment that results from the MMA may result in a similar reduction in payments from
non-governmental payers.
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On February 17, 2009, the American Recovery and Reinvestment Act of 2009 was signed into law. This law provides funding for the federal
government to compare the effectiveness of different treatments for the same illness. A plan for the research will be developed by the Department of Health
and Human Services, the Agency for Healthcare Research and Quality and the National Institutes of Health, and periodic reports on the status of the
research and related expenditures will be made to Congress. Although the results of the comparative effectiveness studies are not intended to mandate
coverage policies for public or private payers, it is not clear how such a result could be avoided and what if any effect the research will have on the sales of
our product candidates, if any such product or the condition that it is intended to treat is the subject of a study. It is also possible that comparative
effectiveness research demonstrating benefits in a competitor’s product could adversely affect the sales of our product candidates. Decreases in third-party
reimbursement for our product candidates or a decision by a third-party payer to not cover our product candidates could reduce physician usage of the
product candidates and have a material adverse effect on our sales, results of operations and financial condition.
Employees and Human Capital Resources
As of the date of this report, we have four employees, including our executive officers, and several consultants providing technical, financial and
general administrative services.
Our human capital resources objectives include, as applicable, identifying, recruiting, retaining, incentivizing and integrating our existing and new
employees, advisors and consultants. The principal purposes of our equity incentive plans are to attract, retain and reward personnel through the granting of
stock-based compensation awards, in order to increase stockholder value and the success of our company by motivating such individuals to perform to the
best of their abilities and achieve our objectives.
Available Information
Our website is located at www.tffpharma.com. The information on or accessible through our website is not part of this annual report on Form 10-
K. A copy of this annual report on Form 10-K is located at the SEC’s Public Reference Room at 100 F Street, NE, Washington, D.C. 20549. Information on
the operation of the Public Reference Room can be obtained by calling the SEC at 1-800-SEC-0330. The SEC also maintains an internet site that contains
reports and other information regarding our filings at www.sec.gov.
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Item 1A. Risk Factors
Investing in our common stock involves a high degree of risk. Before purchasing our common stock, you should read and consider carefully the
following risk factors as well as all other information contained in this report, including our financial statements and the related notes. Each of these risk
factors, either alone or taken together, could adversely affect our business, operating results and financial condition, as well as adversely affect the value of
an investment in our common stock. There may be additional risks that we do not presently know of or that we currently believe are immaterial, which
could also impair our business and financial position. If any of the events described below were to occur, our financial condition, our ability to access
capital resources, our results of operations and/or our future growth prospects could be materially and adversely affected and the market price of our
common stock could decline. As a result, you could lose some or all of any investment you may make in our common stock.
Risks Related to Our Business
We are a clinical-stage biopharmaceutical company with limited operating history. We are a biopharmaceutical company, newly-formed in
January 2018, and have limited operating history. We have not commenced revenue-producing operations. In November 2019, we initiated Phase I human
clinical trials for our TFF VIP product candidate and in June 2020, we initiated Phase I human clinical trials for our TFF TIP product candidate, however,
to date, our operations have otherwise consisted of preliminary research and development, drug formulation and characterization and testing of our initial
product candidates. Our limited operating history makes it difficult for potential investors to evaluate our technology or prospective operations. As a
development stage biopharmaceutical company, we are subject to all the risks inherent in the organization, financing, expenditures, complications and
delays involved with a new business. Accordingly, you should consider our prospects in light of the costs, uncertainties, delays and difficulties frequently
encountered by companies in the early stages of development, especially clinical-stage biopharmaceutical companies such as ours. Potential investors
should carefully consider the risks and uncertainties that a company with a limited operating history will face. In particular, potential investors should
consider that we may be unable to:
● successfully implement or execute our business plan, or ensure that our business plan is sound;
● successfully complete pre-clinical and clinical trials and obtain regulatory approval for the marketing of our product candidates;
● successfully demonstrate a favorable differentiation between our dry powder candidates and the current products on the market;
● successfully contract for the manufacture of our clinical drug products and establish a commercial drug supply;
● secure market exclusivity and/or adequate intellectual property protection for our product candidates;
● attract and retain an experienced management and advisory team; and
● raise sufficient funds in the capital markets to effectuate our business plan, including product and clinical development, regulatory approval
and commercialization for our product candidates.
Investors should evaluate an investment in us in light of the uncertainties encountered by developing companies in a competitive environment.
There can be no assurance that our efforts will be successful or that we will ultimately be able to attain profitability. If we cannot successfully execute any
one of the foregoing, our business may not succeed and your investment will be adversely affected. You must be prepared to lose all of your investment.
We have a history of significant operating losses and anticipate continued operating losses for the foreseeable future. For the fiscal years ended
December 31, 2020 and 2019, we incurred a net loss applicable to common stockholders of $18.6 million and $36.7 million, respectively. As of December
31, 2020, we had an accumulated deficit of $34.3 million. We expect to continue to incur substantial expenses without any corresponding revenues unless
and until we are able to obtain regulatory approval and successfully commercialize at least one of our product candidates. However, there can be no
assurance we will be able to obtain regulatory approval for any of our product candidates. Even if we are able to obtain regulatory approval and
subsequently commercialize our product candidates, there can be no assurance that we will generate significant revenues or ever achieve profitability.
We expect to have significant research, regulatory and development expenses as we advance our product candidates towards commercialization.
As a result, we expect to incur substantial losses for the foreseeable future, and these losses will be increasing. We are uncertain when or if we will be able
to achieve or sustain profitability. If we achieve profitability in the future, we may not be able to sustain profitability in subsequent periods. Failure to
become and remain profitable may impair our ability to sustain operations and adversely affect our business and our ability to raise capital. If we are unable
to generate positive cash flow within a reasonable period of time, we may be unable to further pursue our business plan or continue operations, in which
case you may lose your entire investment.
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We expect we will need additional financing to execute our business plan and fund operations, which additional financing may not be
available on reasonable terms or at all. As of December 31, 2020, we had total assets of approximately $38.7 million and working capital of
approximately $36.2 million. As of December 31, 2020, our liquidity included approximately $35.3 million of cash and cash equivalents. We believe that
our cash on-hand as of the date of this report is sufficient to fund our proposed operating plan for, at least, the 12 months following the date of this report.
However, as of the date of this report, we believe that we will need additional capital to fund our operations through to the marketing approval for TFF VIP
and TFF TIP, assuming such approval can be obtained at all, and to engage in the substantial development of any other of our drug candidates, such as
formulation, early stage animal testing and formal toxicology studies. We intend to seek additional funds through various financing sources, including the
sale of our equity and debt securities, licensing fees for our technology and co-development and joint ventures with industry partners, with a preference
towards licensing fees for our technology and co-development and joint ventures with industry partners. In addition, we will consider alternatives to our
current business plan that may enable to us to achieve revenue producing operations and meaningful commercial success with a smaller amount of capital.
However, there can be no guarantees that such funds will be available on commercially reasonable terms, if at all. If such financing is not available on
satisfactory terms, we may be unable to further pursue our business plan and we may be unable to continue operations, in which case you may lose your
entire investment.
Our business model is entirely dependent on certain patent rights licensed to us from the University of Texas at Austin, and the loss of those
license rights would, in all likelihood, cause our business, as presently contemplated, to fail. In July 2015, the University of Texas at Austin, or UT,
granted to our former parent, LTI, an exclusive worldwide, royalty bearing license to the patent rights for the TFF platform in all fields of use, other than
vaccines. In March 2018, LTI assigned to us all of its interest to the TFF platform, including the patent license agreement with UT. In November 2018, we
and UT amended the patent license agreement such that our exclusive patent rights to the TFF platform were expanded to all fields of use. Our current
business model, which focuses exclusively on the development of drugs using the TFF technology, is based entirely on the availability of the patent rights
licensed to us by UT under the patent license agreement. The patent license agreement requires us to pay royalties and milestone payments and conform to
a variety of covenants and agreements, and in the event of our breach of the agreement, UT may elect to terminate the agreement. As of the date of this
report, we believe we are in compliance with the patent license agreement and consider our relationship with UT to be excellent. However, in the event of
our breach of the patent license agreement for any reason, and our inability to cure such breach within any cure period or obtain a waiver from UT, we
could lose the patent license agreement, which would result in our loss of all rights to the TFF technology.
Our business may be adversely affected by the recent COVID-19 outbreak. In December 2019, a novel strain of coronavirus, COVID-19, was
reported to have surfaced in Wuhan, China. In January 2020, this coronavirus spread to other countries, including the United States, and efforts to contain
the spread of COVID-19 have intensified. At this time, the United States and certain other countries are the subject of lock-downs and self-isolation
procedures, which have significantly limited business operations and restricted internal and external meetings. We had expected to commence Phase 1
clinical trials our TFF formulation of Tacrolimus, or TFF TIP, in Australia in the first quarter of 2020, and on March 13, 2020 we had received the approval
of the Australian Human Research Ethics Committee to commence Phase 1 trials. However, later in March 2020, our contract research organization partner
in Australia informed us that because of the spread of the COVID-19 virus in Australia, there would be a delay in initiating the trials. One contributing
factor is that Tacrolimus is an immunosuppressant drug and, given the threat of the COVID-19 virus, we were concerned that even though we would be
dosing healthy volunteers the inhalation of an immunosuppressant could increase the risk of severe complications if a volunteer was to contract COVID-19.
In June 2020, we were able to begin dosing in the Phase I trial our TFF TIP in Melbourne, however, in July 2020, due to the resurgence of COVID-19 in
the Melbourne area, the Phase I trials were delayed. With the flaring of COVID-19 in the Melbourne area and in order to remain dynamic, a second clinical
trial site in Brisbane, Queensland, Australia was opened and we resumed dosing in the Phase I clinical trials during the third quarter of 2020. Further, the
outbreak and any preventative or protective actions that we or our customers may take in respect of COVID-19 may result in a period of disruption to other
work in progress. Our customers’ businesses could be disrupted, and our future costs and potential revenues and technology evaluations could be
negatively affected. Any resulting financial impact cannot be reasonably estimated at this time but may materially affect our business and financial
condition. The extent to which COVID-19 impacts our results will depend on future developments, which are highly uncertain and cannot be predicted,
including new information which may emerge concerning the severity of COVID-19 and the actions to contain COVID-19 or treat its impact, among
others.
We currently have no sales and marketing organization. If we are unable to establish satisfactory sales and marketing capabilities or secure a
third-party sales and marketing relationship, we may not be able to successfully commercialize any of our product candidates. At present, we have no
sales or marketing personnel. Upon and subject to initial receipt of the requisite regulatory approvals for one or more of our drug products, we intend to
commercialize our drug products through a combination of our internal direct sales force, third-party marketing and distribution relationships. In some
cases, such as involving the development of combination drugs or the development of dry powder formulations of patented drugs, we intend to pursue the
licensing of our TFF technology or enter into a joint development arrangement. If we are not successful in recruiting sales and marketing personnel and
building a sales and marketing infrastructure or entering into appropriate collaboration arrangements with third parties, we will have difficulty successfully
commercializing our product candidates, which would adversely affect our business, operating results and financial condition.
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Even if we enter into third-party marketing and distribution arrangements, we may have limited or no control over the sales, marketing and
distribution activities of these third parties. Our future revenues may depend heavily on the success of the efforts of these third parties. In terms of
establishing a sales and marketing infrastructure, we will have to compete with established and well-funded pharmaceutical and biotechnology companies
to recruit, hire, train and retain sales and marketing personnel. Factors that may inhibit our efforts to build an internal sales organization or enter into
collaboration arrangements with third parties include:
● our inability to recruit and retain adequate numbers of effective sales and marketing personnel;
● the inability of sales personnel to obtain access to or persuade adequate numbers of physicians to prescribe any of our product candidates;
● the lack of complementary products to be offered by sales personnel, which may put us at a competitive disadvantage relative to companies
with more extensive product lines; and
● unforeseen costs and expenses associated with creating an internal sales and marketing organization.
We will be completely dependent on third parties to manufacture our product candidates, and the commercialization of our product candidates
could be halted, delayed or made less profitable if those third parties fail to obtain manufacturing approval from the FDA or comparable foreign
regulatory authorities fail to provide us with sufficient quantities of our product candidates or fail to do so at acceptable quality levels or prices. We do
not currently have, nor do we plan to acquire, the capability or infrastructure to manufacture our drug candidates for use in our clinical trials or for
commercial sales, if any. As a result, we will be obligated to rely on contract manufacturers, if and when any of our product candidates are approved for
commercialization. We have entered into short-term contract manufacturing agreements with IriSys, Inc. and CoreRx, Inc. for their provision of certain
product testing, development and clinical manufacturing services for our TFF VIP and TFF TIP product candidates, respectively, and we are currently in
discussion with several contract manufacturers for the commercial supply of any drug candidates we are able to bring to market. However, we have not
entered into agreements with any contract manufacturers for commercial supply and may not be able to engage contract manufacturers for commercial
supply of any of our product candidates on favorable terms to us, or at all, should the need arise.
The facilities used by our current and future contract manufacturers to manufacture our product candidates must be approved by the FDA or
comparable foreign regulatory authorities. Such approvals are subject to inspections that will be conducted after we submit a New Drug Application, or
NDA, or Biologics License Application, or BLA, to the FDA or their equivalents to other relevant regulatory authorities. We will not control the
manufacturing process of our product candidates, and will be completely dependent on our contract manufacturing partners for compliance with Current
Good Manufacturing Practices, or cGMPs, for manufacture of both active drug substances and finished drug products. These cGMP regulations cover all
aspects of the manufacturing, testing, quality control, storage, distribution and record keeping relating to our product candidates. If our contract
manufacturers do not successfully manufacture material that conforms to our specifications and the strict regulatory requirements of the FDA or others, we
will not be able to secure or maintain regulatory approval for product made at their manufacturing facilities. If the FDA or a comparable foreign regulatory
authority does not approve these facilities for the manufacture of our product candidates or if it withdraws any such approval in the future, we may need to
find alternative manufacturing facilities, which would significantly impact our ability to develop, manufacture, obtain regulatory approval for or market our
product candidates, if approved. Likewise, we could be negatively impacted if any of our contract manufacturers elect to discontinue their business
relationship with us.
Our contract manufacturers will be subject to ongoing periodic unannounced inspections by the FDA and corresponding state and foreign agencies
for compliance with cGMPs and similar regulatory requirements. We will not have control over our contract manufacturers’ compliance with these
regulations and standards. Failure by any of our contract manufacturers to comply with applicable regulations could result in sanctions being imposed on
us, including fines, injunctions, civil penalties, failure to grant approval to market any of our product candidates, delays, suspensions or withdrawals of
approvals, inability to supply product, operating restrictions and criminal prosecutions, any of which could significantly and adversely affect our business.
In addition, we will not have control over the ability of our contract manufacturers to maintain adequate quality control, quality assurance and qualified
personnel. Failure by our contract manufacturers to comply with or maintain any of these standards could adversely affect our ability to develop,
manufacture, obtain regulatory approval for or market any of our product candidates, if approved.
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If, for any reason, these third parties are unable or unwilling to perform we may not be able to locate alternative manufacturers or formulators or
enter into favorable agreements with them and we cannot be certain that any such third parties will have the manufacturing capacity to meet future
requirements. If these manufacturers or any alternate manufacturer of finished drug product experiences any significant difficulties in its respective
manufacturing processes for our active pharmaceutical ingredients, or APIs, or finished products or should cease doing business with us for any reason, we
could experience significant interruptions in the supply of any of our product candidates or may not be able to create a supply of our product candidates at
all. Were we to encounter manufacturing difficulties, our ability to produce a sufficient supply of any of our product candidates might be negatively
affected. Our inability to coordinate the efforts of our third-party manufacturing partners, or the lack of capacity available at our third-party manufacturing
partners, could impair our ability to supply any of our product candidates at required levels. Because of the significant regulatory requirements that we
would need to satisfy in order to qualify a new bulk drug substance or finished product manufacturer, if we face these or other difficulties with our then
current manufacturing partners, we could experience significant interruptions in the supply of any of our product candidates if we decided to transfer the
manufacture of any of our product candidates to one or more alternative manufacturers in an effort to deal with such difficulties.
Any manufacturing problem or the loss of a contract manufacturer could be disruptive to our operations and result in development delays and lost
sales. Additionally, we will rely on third parties to supply the raw materials needed to manufacture our product candidates. Any such reliance on suppliers
may involve several risks, including a potential inability to obtain critical materials and reduced control over production costs, delivery schedules,
reliability and quality. Any unanticipated disruption to the operation of one of our contract manufacturers caused by problems with suppliers could delay
shipment of any of our product candidates, increase our cost of goods sold and result in lost sales.
If product liability lawsuits are brought against us, we may incur substantial liabilities and may be required to limit commercialization of our
product candidates. We will face a potential risk of product liability as a result of the clinical testing of our product candidates and will face an even greater
risk of such liability if we commercialize any of our product candidates. For example, we may be sued if any product we develop, including any of our
product candidates, or any materials that we use in our product candidates allegedly causes injury or is found to be otherwise unsuitable during product
testing, manufacturing, marketing or sale. Any such product liability claims may include allegations of defects in manufacturing, defects in design, a failure
to warn of dangers inherent in the product, negligence, strict liability and a breach of warranties. In the U.S., claims could also be asserted against us under
state consumer protection acts. If we cannot successfully defend ourselves against product liability claims, we may incur substantial liabilities or be
required to limit commercialization of our product candidates. Even successful defense of these claims would require us to employ significant financial and
management resources. Regardless of the merits or eventual outcome, liability claims may result in:
● decreased demand for any of our product candidates or any future products that we may develop;
● injury to our reputation;
● failure to obtain regulatory approval for our product candidates;
● withdrawal of participants in our clinical trials;
● costs associated with our defense of the related litigation;
● a diversion of our management’s time and our resources;
● substantial monetary awards to trial participants or patients;
● product recalls, withdrawals or labeling, marketing or promotional restrictions;
● the inability to commercialize some or all of our product candidates; and
● a decline in the value of our stock.
As of the date of this report, we have procured insurance coverage for our human clinical trials, which we consider adequate for our current level
of clinical testing and development, however we do not carry product liability insurance. We intend to obtain product liability insurance at the time we
commence commercial sale of our initial product. Our inability to obtain and retain sufficient product liability insurance at an acceptable cost to protect
against potential product liability claims could prevent or inhibit the commercialization of products we develop. Although we will endeavor to obtain and
maintain such insurance in coverage amounts we deem adequate, any claim that may be brought against us could result in a court judgment or settlement in
an amount that is not covered, in whole or in part, by our insurance or that is in excess of the limits of our insurance coverage. Our insurance policies
would also have various exclusions, and we may be subject to a product liability claim for which we have no coverage. As a result, we may have to pay any
amounts awarded by a court or negotiated in a settlement that exceed our coverage limitations or that are not covered by our insurance, and we may not
have, or be able to obtain, sufficient capital to pay such amounts.
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Our business operations could suffer in the event of information technology systems’ failures or security breaches. While we believe that we
have implemented adequate security measures within our internal information technology and networking systems, our information technology systems
may be subject to security breaches, damages from computer viruses, natural disasters, terrorism, and telecommunication failures. Any system failure or
security breach could cause interruptions in our operations in addition to the possibility of losing proprietary information and trade secrets. To the extent
that any disruption or security breach results in inappropriate disclosure of our confidential information, our competitive position may be adversely affected
and we may incur liability or additional costs to remedy the damages caused by these disruptions or security breaches.
Sales of counterfeit versions of our product candidates, as well as unauthorized sales of our product candidates, may have adverse effects on
our revenues, business, results of operations and damage our brand and reputation. Our product candidates may become subject to competition from
counterfeit pharmaceutical products, which are pharmaceutical products sold under the same or very similar brand names and/or having a similar
appearance to genuine products, but which are sold without proper licenses or approvals. Such products divert sales from genuine products, often are of
lower cost and quality (having different ingredients or formulations, for example), and have the potential to damage the reputation for quality and
effectiveness of the genuine product. Obtaining regulatory approval for our product candidates is a complex and lengthy process. If during the period while
the regulatory approval is pending illegal sales of counterfeit products begin, consumers may buy such counterfeit products, which could have an adverse
impact on our revenues, business and results of operations. In addition, if illegal sales of counterfeits result in adverse side effects to consumers, we may be
associated with any negative publicity resulting from such incidents. Although pharmaceutical regulation, control and enforcement systems throughout the
world have been increasingly active in policing counterfeit pharmaceuticals, we may not be able to prevent third parties from manufacturing, selling or
purporting to sell counterfeit products competing with our product candidates. Such sales may also be occurring without our knowledge. The existence and
any increase in production or sales of counterfeit products or unauthorized sales could negatively impact our revenues, brand reputation, business and
results of operations.
Risks Related to Product Regulation
Our success is entirely dependent on our ability to obtain the marketing approval for our product candidates by the FDA and the regulatory
authorities in foreign jurisdictions in which we intend to market our product candidates, of which there can be no assurance. We are not permitted to
market our product candidates as prescription pharmaceutical products in the United States until we receive approval of an NDA from the FDA, or in any
foreign countries until we receive the requisite approval from such countries. In the United States, the FDA generally requires the completion of clinical
trials of each drug to establish its safety and efficacy and extensive pharmaceutical development to ensure its quality before an NDA is approved. Of the
large number of drugs in development, only a small percentage result in the submission of an NDA to the FDA and even fewer are eventually approved for
commercialization. As of the date of this report, we have not submitted an NDA to the FDA or comparable applications to other regulatory authorities for
any of our product candidates.
Because our initial dry powder drug candidates, TFF VIP and TFF TIP, will be established drugs that are off-patent, we believe that our initial
drug product candidates will qualify for FDA approval through the FDA’s 505(b)(2) regulatory pathway and in corresponding regulatory paths in other
foreign jurisdictions. The 505(b)(2) pathway sometimes does not require clinical trials other than a bioequivalence trial; however, to the extent we claim
that our drug product candidates target a new indication or offer improved safety compared to the existing approved products, and it is our present
expectation that we will do so in many cases, it is likely that we will be required to conduct additional clinical trials in order to obtain marketing approval.
For example, based on separate pre-IND meetings with the FDA concerning TFF VIP and TFF TIP, we believe we will need to conduct Phase I and Phase
II studies prior to filing for marketing approval for TFF VIP and Phase I and Phase IIb/IIIa studies prior to filing for marketing approval for TFF TIP.
However, there can be no assurance that the FDA will not ask for additional clinical data for either TFF VIP or TFF TIP.
Our business model is to pursue the development of off-patent drugs for which we would directly pursue the development of a dry powder
formulation through the FDA’s 505(b)(2) regulatory pathway; however, not all of our product candidates will target off-patent drugs and, at least in the case
of a dry powder formulation of CBD, our product candidate may not be a drug. We do not expect any dry powder formulation of a CBD drug product to be
off-patent and our proposed dry powder formulation of aluminum salt vaccines may not be off-patent. We also expect that our dry powder formulation of a
CBD drug product will likely require a full NDA through the FDA’s 505(b)(1) regulatory pathway; however, a non-pharmaceutical CBD dry powder
formulation may not require FDA approval. We expect that our dry powder formulation of aluminum salt vaccines will require a biological license
application, or BLA, which is very similar to a full NDA through the FDA’s 505(b)(1) regulatory pathway.
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Our success depends on our receipt of the regulatory approvals described above, and the issuance of such regulatory approvals is uncertain and
subject to a number of risks, including the following:
● the results of toxicology studies may not support the filing of an IND for our product candidates;
● the FDA or comparable foreign regulatory authorities or Institutional Review Boards, or IRB, may disagree with the design or implementation
of our clinical trials;
● we may not be able to provide acceptable evidence of our product candidates’ safety and efficacy;
● the results of our clinical trials may not be satisfactory or may not meet the level of statistical or clinical significance required by the FDA,
European Medicines Agency, or EMA, or other regulatory agencies for us to receive marketing approval for any of our product candidates;
● the dosing of our product candidates in a particular clinical trial may not be at an optimal level;
● patients in our clinical trials may suffer adverse effects for reasons that may or may not be related to our product candidates;
● the data collected from clinical trials may not be sufficient to support the submission of an NDA, BLA or other submission or to obtain
regulatory approval in the United States or elsewhere;
● the FDA or comparable foreign regulatory authorities may fail to approve the manufacturing processes or facilities of third-party
manufacturers with which we contract for clinical and commercial supplies; and
● the approval policies or regulations of the FDA or comparable foreign regulatory authorities may significantly change in a manner rendering
our clinical data insufficient for approval of our product candidates.
The process of obtaining regulatory approvals is expensive, often takes many years, if approval is obtained at all, and can vary substantially based
upon, among other things, the type, complexity and novelty of the product candidates involved, the jurisdiction in which regulatory approval is sought and
the substantial discretion of the regulatory authorities. Changes in regulatory approval policies during the development period, changes in or the enactment
of additional statutes or regulations, or changes in regulatory review for a submitted product application may cause delays in the approval or rejection of an
application. Regulatory approval obtained in one jurisdiction does not necessarily mean that a product candidate will receive regulatory approval in all
jurisdictions in which we may seek approval, but the failure to obtain approval in one jurisdiction may negatively impact our ability to seek approval in a
different jurisdiction. Failure to obtain regulatory approval for our product candidates for the foregoing, or any other reasons, will prevent us from
commercializing our product candidates, and our ability to generate revenue will be materially impaired.
Clinical testing is expensive, is difficult to design and implement, can take many years to complete and is uncertain as to outcome. Our
business model depends entirely on the successful development, regulatory approval and commercialization of our product candidates, which may never
occur. In November 2019, we initiated Phase I human clinical trials for our TFF VIP product candidate and initiated Phase I human clinical trials for our
TFF TIP product candidate in June 2020. However, as of the date of this report, we have not otherwise progressed any of our product candidates beyond
performance characterization and animal testing. We may not be successful in obtaining approval from the FDA or comparable foreign regulatory
authorities to start clinical trials for any other of our product candidates. If we do not obtain such approvals as presently planned, the time in which we
expect to commence clinical programs for any product candidate will be extended and such extension will increase our expenses, delay our potential receipt
of any revenues, and increase our need for additional capital. Moreover, there is no guarantee that we will receive approval to commence human clinical
trials or, if we do receive approval, that our clinical trials will be successful or that we will continue clinical development in support of an approval from the
FDA or comparable foreign regulatory authorities for any indication. We note that most product candidates never reach the clinical development stage and
even those that do commence clinical development have only a small chance of successfully completing clinical development and gaining regulatory
approval. Success in early phases of pre-clinical and clinical trials does not ensure that later clinical trials will be successful, and interim results of a clinical
trial do not necessarily predict final results. A failure of one or more of our clinical trials can occur at any stage of testing. We may experience numerous
unforeseen events during, or as a result of, the clinical trial process that could delay or prevent our ability to receive regulatory approval or commercialize
our product candidates. Therefore, our business currently depends entirely on the successful development, regulatory approval and commercialization of
our product candidates, which may never occur.
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Even if we receive regulatory approval for any of our product candidates, we may not be able to successfully commercialize the product and
the revenue that we generate from its sales, if any, may be limited. If approved for marketing, the commercial success of our product candidates will
depend upon each product’s acceptance by the medical community, including physicians, patients and health care payors. The degree of market acceptance
for any of our product candidates will depend on a number of factors, including:
● demonstration of clinical safety and efficacy;
● relative convenience, dosing burden and ease of administration;
● the prevalence and severity of any adverse effects;
● the willingness of physicians to prescribe our product candidates, and the target patient population to try new therapies;
● efficacy of our product candidates compared to competing products;
● the introduction of any new products that may in the future become available targeting indications for which our product candidates may be
approved;
● new procedures or therapies that may reduce the incidences of any of the indications in which our product candidates may show utility;
● pricing and cost-effectiveness;
● the inclusion or omission of our product candidates in applicable therapeutic and vaccine guidelines;
● the effectiveness of our own or any future collaborators’ sales and marketing strategies;
● limitations or warnings contained in approved labeling from regulatory authorities;
● our ability to obtain and maintain sufficient third-party coverage or reimbursement from government health care programs, including
Medicare and Medicaid, private health insurers and other third-party payors or to receive the necessary pricing approvals from government
bodies regulating the pricing and usage of therapeutics; and
● the willingness of patients to pay out-of-pocket in the absence of third-party coverage or reimbursement or government pricing approvals.
If any of our product candidates are approved, but do not achieve an adequate level of acceptance by physicians, health care payors, and patients,
we may not generate sufficient revenue and we may not be able to achieve or sustain profitability. Our efforts to educate the medical community and third-
party payors on the benefits of our product candidates may require significant resources and may never be successful.
In addition, even if we obtain regulatory approvals, the timing or scope of any approvals may prohibit or reduce our ability to commercialize our
product candidates successfully. For example, if the approval process takes too long, we may miss market opportunities and give other companies the
ability to develop competing products or establish market dominance. Any regulatory approval we ultimately obtain may be limited or subject to
restrictions or post-approval commitments that render our product candidates not commercially viable. For example, regulatory authorities may approve
any of our product candidates for fewer or more limited indications than we request, may not approve the price we intend to charge for any of our product
candidates, may grant approval contingent on the performance of costly post-marketing clinical trials, or may approve any of our product candidates with a
label that does not include the labeling claims necessary or desirable for the successful commercialization of that indication. Further, the FDA or
comparable foreign regulatory authorities may place conditions on approvals or require risk management plans or a Risk Evaluation and Mitigation
Strategy, or REMS, to assure the safe use of the drug. Moreover, product approvals may be withdrawn for non-compliance with regulatory standards or if
problems occur following the initial marketing of the product. Any of the foregoing scenarios could materially harm the commercial success of our product
candidates.
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Even if we obtain marketing approval for any of our product candidates, we will be subject to ongoing obligations and continued regulatory
review, which may result in significant additional expense. Additionally, our product candidates could be subject to labeling and other restrictions and
withdrawal from the market and we may be subject to penalties if we fail to comply with regulatory requirements or if we experience unanticipated
problems with our product candidates. Even if we obtain regulatory approval for any of our product candidates for an indication, the FDA or foreign
equivalent may still impose significant restrictions on their indicated uses or marketing or the conditions of approval, or impose ongoing requirements for
potentially costly and time-consuming post-approval studies, including Phase 4 clinical trials, and post-market surveillance to monitor safety and efficacy.
Our product candidates will also be subject to ongoing regulatory requirements governing the manufacturing, labeling, packaging, storage, distribution,
safety surveillance, advertising, promotion, recordkeeping and reporting of adverse events and other post-market information. These requirements include
registration with the FDA, as well as continued compliance with current Good Clinical Practices regulations, or cGCPs, for any clinical trials that we
conduct post-approval. In addition, manufacturers of drug products and their facilities are subject to continual review and periodic inspections by the FDA
and other regulatory authorities for compliance with current cGMPs, requirements relating to quality control, quality assurance and corresponding
maintenance of records and documents.
The FDA has the authority to require a REMS as part of an NDA or after approval, which may impose further requirements or restrictions on the
distribution or use of an approved drug, such as limiting prescribing to certain physicians or medical centers that have undergone specialized training,
limiting treatment to patients who meet certain safe-use criteria or requiring patient testing, monitoring and/or enrollment in a registry.
With respect to sales and marketing activities related to our product candidates, advertising and promotional materials must comply with FDA
rules in addition to other applicable federal, state and local laws in the United States and similar legal requirements in other countries. In the United States,
the distribution of product samples to physicians must comply with the requirements of the U.S. Prescription Drug Marketing Act. Application holders
must obtain FDA approval for product and manufacturing changes, depending on the nature of the change. We may also be subject, directly or indirectly
through our customers and partners, to various fraud and abuse laws, including, without limitation, the U.S. Anti-Kickback Statute, U.S. False Claims Act,
and similar state laws, which impact, among other things, our proposed sales, marketing, and scientific/educational grant programs. If we participate in the
U.S. Medicaid Drug Rebate Program, the Federal Supply Schedule of the U.S. Department of Veterans Affairs, or other government drug programs, we
will be subject to complex laws and regulations regarding reporting and payment obligations. All of these activities are also potentially subject to U.S.
federal and state consumer protection and unfair competition laws. Similar requirements exist in many of these areas in other countries.
In addition, if any of our product candidates are approved for a particular indication, our product labeling, advertising and promotion would be
subject to regulatory requirements and continuing regulatory review. The FDA strictly regulates the promotional claims that may be made about
prescription products. In particular, a product may not be promoted for uses that are not approved by the FDA as reflected in the product’s approved
labeling. If we receive marketing approval for our product candidates, physicians may nevertheless legally prescribe our products to their patients in a
manner that is inconsistent with the approved label. If we are found to have promoted such off-label uses, we may become subject to significant liability
and government fines. The FDA and other agencies actively enforce the laws and regulations prohibiting the promotion of off-label uses, and a company
that is found to have improperly promoted off-label uses may be subject to significant sanctions. The federal government has levied large civil and criminal
fines against companies for alleged improper promotion and has enjoined several companies from engaging in off-label promotion. The FDA has also
requested that companies enter into consent decrees of permanent injunctions under which specified promotional conduct is changed or curtailed.
If we or a regulatory agency discover previously unknown problems with a product candidate, such as adverse events of unanticipated severity or
frequency, problems with the facility where the product is manufactured, or we or our manufacturers fail to comply with applicable regulatory
requirements, we may be subject to the following administrative or judicial sanctions:
● restrictions on the marketing or manufacturing of the product, withdrawal of the product from the market, or voluntary or mandatory product
recalls;
● issuance of warning letters or untitled letters;
● clinical holds;
● injunctions or the imposition of civil or criminal penalties or monetary fines;
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● suspension or withdrawal of regulatory approval;
● suspension of any ongoing clinical trials;
● refusal to approve pending applications or supplements to approved applications filed by us, or suspension or revocation of product license
approvals;
● suspension or imposition of restrictions on operations, including costly new manufacturing requirements; or
● product seizure or detention or refusal to permit the import or export of product.
The occurrence of any event or penalty described above may inhibit our ability to commercialize our product candidates and generate revenue.
Adverse regulatory action, whether pre- or post-approval, can also potentially lead to product liability claims and increase our product liability exposure.
Obtaining and maintaining regulatory approval of our product candidates in one jurisdiction does not mean that we will be successful in
obtaining regulatory approval of our product candidates in other jurisdictions. Obtaining and maintaining regulatory approval of our product candidates
in one jurisdiction does not guarantee that we will be able to obtain or maintain regulatory approval in any other jurisdiction, but a failure or delay in
obtaining regulatory approval in one jurisdiction may have a negative effect on the regulatory approval process in others. For example, even if the FDA
grants marketing approval of a product candidate, comparable regulatory authorities in foreign jurisdictions must also approve the manufacturing,
marketing and promotion of the product candidate in those countries. Approval procedures vary among jurisdictions and can involve requirements and
administrative review periods different from those in the United States, including additional preclinical studies or clinical trials, as clinical studies
conducted in one jurisdiction may not be accepted by regulatory authorities in other jurisdictions. In many jurisdictions outside the United States, a product
candidate must be approved for reimbursement before it can be approved for sale in that jurisdiction. In some cases, the price that we intend to charge for
our products is also subject to approval.
Obtaining foreign regulatory approvals and compliance with foreign regulatory requirements could result in significant delays, difficulties and
costs for us and could delay or prevent the introduction of our product candidates in certain countries. If we fail to comply with the regulatory requirements
in international markets and/ or to receive applicable marketing approvals, our target market will be reduced and our ability to realize the full market
potential of our product candidates will be harmed.
Even though we may apply for orphan drug designation for a product candidate, we may not be able to obtain orphan drug marketing
exclusivity. We believe that in some cases our dry powder drug products may qualify for the FDA’s orphan drug status. There is no guarantee that the FDA
will grant any future application for orphan drug designation for any of our product candidates, which would make us ineligible for the additional
exclusivity and other benefits of orphan drug designation.
Under the Orphan Drug Act, the FDA may grant orphan drug designation to a drug intended to treat a rare disease or condition, which is generally
a disease or condition that affects fewer than 200,000 individuals in the United States and for which there is no reasonable expectation that the cost of
developing and making a drug available in the United States for this type of disease or condition will be recovered from sales of the product. Orphan drug
designation must be requested before submitting an NDA. After the FDA grants orphan drug designation, the identity of the therapeutic agent and its
potential orphan use are disclosed publicly by the FDA. Orphan product designation does not convey any advantage in or shorten the duration of regulatory
review and approval process. In addition to the potential period of exclusivity, orphan designation makes a company eligible for grant funding of up to
$400,000 per year for four years to defray costs of clinical trial expenses, tax credits for clinical research expenses and potential exemption from the FDA
application user fee.
If a product that has orphan designation subsequently receives the first FDA approval for the disease or condition for which it has such
designation, the product is entitled to orphan drug exclusivity, which means the FDA may not approve any other applications to market the same drug for
the same indication for seven years, except in limited circumstances, such as (i) the drug’s orphan designation is revoked; (ii) its marketing approval is
withdrawn; (iii) the orphan exclusivity holder consents to the approval of another applicant’s product; (iv) the orphan exclusivity holder is unable to assure
the availability of a sufficient quantity of drug; or (v) a showing of clinical superiority to the product with orphan exclusivity by a competitor product. If a
drug designated as an orphan product receives marketing approval for an indication broader than what is designated, it may not be entitled to orphan drug
exclusivity. There can be no assurance that we will receive orphan drug designation for any of our product candidates in the indications for which we think
they might qualify, if we elect to seek such applications.
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Current and future legislation may increase the difficulty and cost for us to obtain marketing approval of and commercialize our product
candidates and affect the prices we may obtain. In the United States and some foreign jurisdictions, there have been a number of legislative and regulatory
changes and proposed changes regarding the healthcare system that could prevent or delay marketing approval for our product candidates, restrict or
regulate post-approval activities and affect our ability to profitably sell our product candidates. Legislative and regulatory proposals have been made to
expand post-approval requirements and restrict sales and promotional activities for pharmaceutical products. We do not know whether additional legislative
changes will be enacted, or whether the FDA regulations, guidance or interpretations will be changed, or what the impact of such changes on the marketing
approvals of our product candidates, if any, may be. In addition, increased scrutiny by the U.S. Congress of the FDA’s approval process may significantly
delay or prevent marketing approval, as well as subject us to more stringent product labeling and post-marketing testing and other requirements.
In the United States, the Medicare Modernization Act, or MMA, changed the way Medicare covers and pays for pharmaceutical products. The
legislation expanded Medicare coverage for drug purchases by the elderly and introduced a new reimbursement methodology based on average sales prices
for drugs. In addition, this legislation authorized Medicare Part D prescription drug plans to use formularies where they can limit the number of drugs that
will be covered in any therapeutic class. As a result of this legislation and the expansion of federal coverage of drug products, we expect that there will be
additional pressure to contain and reduce costs. These cost reduction initiatives and other provisions of this legislation could decrease the coverage and
price that we receive for our product candidates and could seriously harm our business. While the MMA applies only to drug benefits for Medicare
beneficiaries, private payors often follow Medicare coverage policy and payment limitations in setting their own reimbursement rates, and any reduction in
reimbursement that results from the MMA may result in a similar reduction in payments from private payors.
The Patient Protection and Affordable Care Act, as amended by the Health Care and Education Affordability Reconciliation Act of 2010 or,
collectively, the Health Care Reform Law, is a sweeping law intended to broaden access to health insurance, reduce or constrain the growth of healthcare
spending, enhance remedies against fraud and abuse, add new transparency requirements for healthcare and health insurance industries, impose new taxes
and fees on the health industry and impose additional health policy reforms. The Health Care Reform Law revised the definition of “average manufacturer
price” for reporting purposes, which could increase the amount of Medicaid drug rebates to states. Further, the law imposed a significant annual fee on
companies that manufacture or import branded prescription drug products.
The Health Care Reform Law remains subject to legislative efforts to repeal, modify or delay the implementation of the law. If the Health Care
Reform Law is repealed or modified, or if implementation of certain aspects of the Health Care Reform Law are delayed, such repeal, modification or delay
may materially adversely impact our business, strategies, prospects, operating results or financial condition. We are unable to predict the full impact of any
repeal, modification or delay in the implementation of the Health Care Reform Law on us at this time. Due to the substantial regulatory changes that will
need to be implemented by Centers for Medicare & Medicaid Services, or CMS, and others, and the numerous processes required to implement these
reforms, we cannot predict which healthcare initiatives will be implemented at the federal or state level, the timing of any such reforms, or the effect such
reforms or any other future legislation or regulation will have on our business.
In addition, other legislative changes have been proposed and adopted in the United States since the Health Care Reform Law was enacted. We
expect that additional federal healthcare reform measures will be adopted in the future, any of which could limit the amounts that federal and state
governments will pay for healthcare products and services, and in turn could significantly reduce the projected value of certain development projects and
reduce or eliminate our profitability.
Any termination or suspension of, or delays in the commencement or completion of, any necessary studies of any of our product candidates for
any indications could result in increased costs to us, delay or limit our ability to generate revenue and adversely affect our commercial prospects. The
commencement and completion of clinical studies can be delayed for a number of reasons, including delays related to:
● the FDA or a comparable foreign regulatory authority failing to grant permission to proceed and placing the clinical study on hold;
● subjects for clinical testing failing to enroll or remain enrolled in our trials at the rate we expect;
● a facility manufacturing any of our product candidates being ordered by the FDA or other government or regulatory authorities to temporarily
or permanently shut down due to violations of cGMP requirements or other applicable requirements, or cross-contaminations of product
candidates in the manufacturing process;
● any changes to our manufacturing process that may be necessary or desired;
● subjects choosing an alternative treatment for the indications for which we are developing our product candidates, or participating in
competing clinical studies;
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● subjects experiencing severe or unexpected drug-related adverse effects;
● reports from clinical testing on similar technologies and products raising safety and/or efficacy concerns;
● third-party clinical investigators losing their license or permits necessary to perform our clinical trials, not performing our clinical trials on our
anticipated schedule or employing methods consistent with the clinical trial protocol, cGMP requirements, or other third parties not
performing data collection and analysis in a timely or accurate manner;
● inspections of clinical study sites by the FDA, comparable foreign regulatory authorities, or IRBs finding regulatory violations that require us
to undertake corrective action, result in suspension or termination of one or more sites or the imposition of a clinical hold on the entire study,
or that prohibit us from using some or all of the data in support of our marketing applications;
● third-party contractors becoming debarred or suspended or otherwise penalized by the FDA or other government or regulatory authorities for
violations of regulatory requirements, in which case we may need to find a substitute contractor, and we may not be able to use some or any
of the data produced by such contractors in support of our marketing applications;
● one or more IRBs refusing to approve, suspending or terminating the study at an investigational site, precluding enrollment of additional
subjects, or withdrawing its approval of the trial; reaching agreement on acceptable terms with prospective contract research organizations, or
CROs, and clinical trial sites, the terms of which can be subject to extensive negotiation and may vary significantly among different CROs
and trial sites;
● deviations of the clinical sites from trial protocols or dropping out of a trial;
● adding new clinical trial sites;
● the inability of the CRO to execute any clinical trials for any reason; and
● government or regulatory delays or “clinical holds” requiring suspension or termination of a trial.
Product development costs for any of our product candidates will increase if we have delays in testing or approval or if we need to perform more
or larger clinical studies than planned. Additionally, changes in regulatory requirements and policies may occur and we may need to amend study protocols
to reflect these changes. Amendments may require us to resubmit our study protocols to the FDA, comparable foreign regulatory authorities, and IRBs for
reexamination, which may impact the costs, timing or successful completion of that study. If we experience delays in completion of, or if we, the FDA or
other regulatory authorities, the IRB, or other reviewing entities, or any of our clinical study sites suspend or terminate any of our clinical studies of any of
our product candidates, its commercial prospects may be materially harmed and our ability to generate product revenues will be delayed. Any delays in
completing our clinical trials will increase our costs, slow down our development and approval process and jeopardize our ability to commence product
sales and generate revenues. Any of these occurrences may harm our business, financial condition and prospects significantly. In addition, many of the
factors that cause, or lead to, termination or suspension of, or a delay in the commencement or completion of, clinical studies may also ultimately lead to
the denial of regulatory approval of our product candidates. In addition, if one or more clinical studies are delayed, our competitors may be able to bring
competing products to market before we do, and the commercial viability of any of our affected product candidates could be significantly reduced.
Third-party coverage and reimbursement and health care cost containment initiatives and treatment guidelines may constrain our future
revenues. Our ability to successfully market our product candidates will depend in part on the level of reimbursement that government health
administration authorities, private health coverage insurers and other organizations provide for the cost of our product candidates and related treatments.
Countries in which any of our product candidates are sold through reimbursement schemes under national health insurance programs frequently require that
manufacturers and sellers of pharmaceutical products obtain governmental approval of initial prices and any subsequent price increases. In certain
countries, including the United States, government-funded and private medical care plans can exert significant indirect pressure on prices. We may not be
able to sell our product candidates profitably if adequate prices are not approved or coverage and reimbursement is unavailable or limited in scope.
Increasingly, third-party payors attempt to contain health care costs in ways that are likely to impact our development of products including:
● failing to approve or challenging the prices charged for health care products;
● introducing reimportation schemes from lower priced jurisdictions;
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● limiting both coverage and the amount of reimbursement for new therapeutic products;
● denying or limiting coverage for products that are approved by the regulatory agencies but are considered to be experimental or
investigational by third-party payors; and
● refusing to provide coverage when an approved product is used in a way that has not received regulatory marketing approval.
Any product candidates we develop that incorporate CBD will be subject to U.S. controlled substance laws and regulations and failure to
comply with these laws and regulations, or the cost of compliance with these laws and regulations, may adversely affect the results of our business
operations, both during clinical development and post approval, and our financial condition. We believe that our TFF platform could be used to
formulate a dry powder version of cannabidiol, or CBD, and we are in the early stages of developing a dry powder form of CBD. CBD is a controlled
substance as defined in the federal Controlled Substances Act of 1970, or CSA. Controlled substances are subject to a high degree of regulation under the
CSA, which establishes, among other things, certain registration, manufacturing quotas, security, recordkeeping, reporting, import, export and other
requirements administered by the federal Drug Enforcement Agency, or DEA. The DEA classifies controlled substances into five schedules: Schedule I, II,
III, IV or V substances. Schedule I substances by definition have a high potential for abuse, have no currently “accepted medical use” in the United States,
lack accepted safety for use under medical supervision, and may not be prescribed, marketed or sold in the United States. Pharmaceutical products
approved for use in the United States may be listed as Schedule II, III, IV or V, with Schedule II substances considered to present the highest potential for
abuse or dependence and Schedule V substances the lowest relative risk of abuse among such substances. Schedule I and II drugs are subject to the strictest
controls under the CSA, including manufacturing and procurement quotas, security requirements and criteria for importation. In addition, dispensing of
Schedule II drugs is further restricted. For example, they may not be refilled without a new prescription.
While cannabis and certain of its derivatives, including CBD, are Schedule I controlled substances, products approved for medical use in the
United States that contain cannabis or cannabis extracts must be placed in Schedules II through V, since approval by the FDA satisfies the “accepted
medical use” requirement. In 2018, the FDA approved Epidiolex, a sesame oil oral solution of CBD, and the DEA scheduled Epidiolex to Schedule V. To
our knowledge, Epidiolex is the only CBD-based drug to have received FDA marketing approval. If we are able to develop a CBD-based dry powder drug
candidate, and the FDA provides market approval for such drug candidate, of which there can be no assurance, the DEA will make a scheduling
determination and place our dry powder CBD-based drug candidate in a schedule other than Schedule I in order for it to be prescribed to patients in the
United States. If we are able to develop a CBD-based dry powder drug candidate, we would be able to favorably cite Epidiolex for purposes of DEA
scheduling; however, there can be no assurance that any CBD-based drug candidate we develop will be listed by the DEA as a Schedule V controlled
substance. Furthermore, if the FDA, DEA or any foreign regulatory authority determines that any of our CBD-based drug candidates may have potential for
abuse, it may require us to generate more clinical data than would otherwise be required, which could increase the cost or delay the launch of such drug
candidate.
Facilities conducting research, manufacturing, distributing, importing or exporting, or dispensing controlled substances must be registered
(licensed) to perform these activities and have the security, control, recordkeeping, reporting and inventory mechanisms required by the DEA to prevent
drug loss and diversion. All these facilities must renew their registrations annually, except dispensing facilities, which must renew every three years. The
DEA conducts periodic inspections of certain registered establishments that handle controlled substances. Obtaining the necessary registrations may result
in delay of the importation, manufacturing or distribution of any CBD-based drug candidates we may develop. Furthermore, failure to maintain compliance
with the CSA, particularly non-compliance resulting in loss or diversion, can result in regulatory action that could have a material adverse effect on our
business, financial condition and results of operations. The DEA may seek civil penalties, refuse to renew necessary registrations, or initiate proceedings to
restrict, suspend or revoke those registrations. In certain circumstances, violations could lead to criminal proceedings.
Individual states have also established controlled substance laws and regulations. Though state-controlled substance laws often mirror federal law,
because the states are separate jurisdictions, they may separately schedule our product candidates as well. While some states automatically schedule a drug
based on federal action, other states schedule drugs through rulemaking or a legislative action. State scheduling may delay commercial sale of any product
for which we obtain federal regulatory approval and adverse scheduling could have a material adverse effect on the commercial attractiveness of such
product. We must also obtain separate state registrations, permits or licenses in order to be able to obtain, handle, and distribute controlled substances for
clinical trials or commercial sale, and failure to meet applicable regulatory requirements could lead to enforcement and sanctions by the states in addition to
those from the DEA or otherwise arising under federal law.
The passage of the 2018 Farm Bill will impact our development of a dry powder version of CBD. The Agriculture Improvement Act of 2018, or
the 2018 Farm Bill, was signed into law on December 20, 2018. This new law excludes hemp from the definition of marijuana for purposes of the CSA,
and legalizes the cultivation and commercial sale of hemp in the United States, subject to state regulation and continuing oversight by federal regulatory
agencies. However, the 2018 Farm Bill does not legalize hemp-derived CBDs. CBDs generally remain a Schedule I controlled substance under the CSA
and the 2018 Farm Bill provides that a CBD will be removed from Schedule I status if, among other requirements, the CBD is derived from hemp produced
by a licensed grower in a manner consistent with the 2018 Farm Bill and associated federal and state regulations.
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In addition, the 2018 Farm Bill did not alter the FDA’s authority to regulate products containing cannabis or cannabis-derived compounds,
including CBD, under the Federal Food, Drug, and Cosmetic Act. Hemp products, including CBDs, that qualify as drugs, food, dietary supplements,
veterinary products, and cosmetics will continue to be regulated by the FDA under the applicable regulatory frameworks. Following passage of the 2018
Farm Bill, the FDA reaffirmed its enforcement authority and reiterated the requirement that a CBD product (hemp-derived or otherwise) that is marketed
with a claim of therapeutic benefit, or with any other disease claim, be approved by the FDA for its intended use before it may be introduced into interstate
commerce. However, we believe that hemp-derived CBD products that are not marketed with a claim of therapeutic benefit, or with any other disease
claim, may not require FDA pre-marketing approval. While we believe that recent legislation, most notably the 2018 Farm Bill, has reduced the amount of
DEA regulation of CBDs, this is a rapidly evolving area of law and there remains some uncertainty surrounding future state regulation of CBDs. In
addition, as of the date of this report, the FDA has approved for marketing only one CBD-based drug product, Epidiolex, and there can be no assurance that
we will not encounter increased costs or delays in pursuing FDA market approval of a CBD-based dry powder formula, assuming we can obtain approval at
all.
Risks Relating to Our Intellectual Property Rights
We are dependent on rights to certain technologies licensed to us. We do not have complete control over these technologies and any loss of our
rights to them could prevent us from selling our product candidates. As noted above, our business model is entirely dependent on certain patent rights
licensed to us by the University of Texas at Austin, or UT. See, “Risk Factors — Risks Relating to Our Business — Our business model is entirely
dependent on certain patent rights licensed to us from the University of Texas at Austin, and the loss of those license rights would, in all likelihood, cause
our business, as presently contemplated, to fail.” Because we will hold those rights as a licensee, we have limited control over certain important aspects of
those patent rights. Pursuant to the patent license agreement, UT has reserved the right to control all decisions concerning the prosecution and maintenance
of all U.S. and foreign patents, as well as all decisions concerning the enforcement of any actions against potential infringers of the patent rights. We
believe that UT shares a common interest in these matters with us, and UT has agreed to consult with us on the prosecution and enforcement of possible
infringement claims as well as other matters for which UT has retained control. However, there can be no assurance that UT will agree with our views as to
how best to prosecute, maintain and defend the patent rights subject to the patent license agreement.
It is difficult and costly to protect our intellectual property rights, and we cannot ensure the protection of these rights. Our commercial success
will depend, in part, on our ability to successfully defend the patent rights subject to our patent license agreement with UT against third-party challenges
and successfully enforcing these patent rights against third party competitors. The patent positions of pharmaceutical companies can be highly uncertain
and involve complex legal, scientific and factual questions for which important legal principles remain unresolved. Changes in either the patent laws or in
interpretations of patent laws may diminish the value of our intellectual property. Accordingly, we cannot predict the breadth of claims that may be
allowable or enforceable in the patent applications subject to the UT patent license agreement. The patents and patent applications relating to our TFF
platform and related technologies may be challenged, invalidated or circumvented by third parties and might not protect us against competitors with similar
products or technologies.
The degree of future protection afforded by the patent rights licensed to us is uncertain, because legal means afford only limited protection and
may not adequately protect our rights, permit us to gain or keep our competitive advantage, or provide us with any competitive advantage at all. We cannot
be certain that any patent application owned by a third party will not have priority over patent applications in which we hold license rights or that we will
not be involved in interference, opposition or invalidity proceedings before United States or foreign patent offices.
Additionally, if UT were to initiate legal proceedings against a third party to enforce a patent covering any of our product candidates, the
defendant could counterclaim that such patent is invalid and/or unenforceable. In patent litigation in the United States, defendant counterclaims alleging
invalidity and/or unenforceability are commonplace. Grounds for a validity challenge include alleged failures to meet any of several statutory requirements,
including lack of novelty, obviousness or non-enablement. Grounds for unenforceability assertions include allegations that someone connected with
prosecution of the patent withheld relevant information from the United States Patent and Trademark Office, or the U.S. PTO, or made a misleading
statement, during prosecution. Third parties may also raise similar claims before administrative bodies in the United States or abroad, even outside the
context of litigation. Such mechanisms include re-examination, post grant review and equivalent proceedings in foreign jurisdictions, e.g. opposition
proceedings. Such proceedings could result in revocation or amendment of UT’s patents in such a way that they no longer cover our product candidates or
competitive products. The outcome following legal assertions of invalidity and unenforceability is unpredictable. With respect to validity, for example, we
cannot be certain that there is no invalidating prior art, of which UT and the patent examiner were unaware during prosecution. If a defendant were to
prevail on a legal assertion of invalidity and/or unenforceability, we would lose at least part, and perhaps all, of the patent protection on any of our product
candidates. Such a loss of patent protection would have a material adverse impact on our business.
30
In the future, we may rely on know-how and trade secrets to protect technology, especially in cases in which we believe patent protection is not
appropriate or obtainable. However, know-how and trade secrets are difficult to protect. While we intend to require employees, academic collaborators,
consultants and other contractors to enter into confidentiality agreements, we may not be able to adequately protect our trade secrets or other proprietary or
licensed information. Typically, research collaborators and scientific advisors have rights to publish data and information in which we may have rights.
Enforcing a claim that a third party illegally obtained and is using any of our trade secrets is expensive and time consuming, and the outcome is
unpredictable. In addition, courts are sometimes less willing to protect trade secrets than patents. Moreover, our competitors may independently develop
equivalent knowledge, methods and know-how.
If we fail to obtain or maintain patent protection or trade secret protection for our product candidates or our technologies, third parties could use
our proprietary information, which could impair our ability to compete in the market and adversely affect our ability to generate revenues and attain
profitability.
Our product candidates may infringe the intellectual property rights of others, which could increase our costs and delay or prevent our
development and commercialization efforts. Our success depends in part on avoiding infringement of the proprietary technologies of others. The
pharmaceutical industry has been characterized by frequent litigation regarding patent and other intellectual property rights. Identification of third-party
patent rights that may be relevant to our proprietary technology is difficult because patent searching is imperfect due to differences in terminology among
patents, incomplete databases and the difficulty in assessing the meaning of patent claims. Additionally, because patent applications are maintained in
secrecy until the application is published, we may be unaware of third-party patents that may be infringed by commercialization of any of our product
candidates or any future product candidate. There may be certain issued patents and patent applications claiming subject matter that we may be required to
license in order to research, develop or commercialize any of our product candidates, and we do not know if such patents and patent applications would be
available to license on commercially reasonable terms, or at all. Any claims of patent infringement asserted by third parties would be time-consuming and
may:
● result in costly litigation;
● divert the time and attention of our technical personnel and management;
● prevent us from commercializing a product until the asserted patent expires or is held finally invalid or not infringed in a court of law;
● require us to cease or modify our use of the technology and/or develop non-infringing technology; or
● require us to enter into royalty or licensing agreements.
Third parties may hold proprietary rights that could prevent any of our product candidates from being marketed. Any patent-related legal action
against us claiming damages and seeking to enjoin commercial activities relating to any of our product candidates or our processes could subject us to
potential liability for damages and require us to obtain a license to continue to manufacture or market any of our product candidates or any future product
candidates. We cannot predict whether we would prevail in any such actions or that any license required under any of these patents would be made
available on commercially acceptable terms, if at all. In addition, we cannot be sure that we could redesign our product candidates or any future product
candidates or processes to avoid infringement, if necessary. Accordingly, an adverse determination in a judicial or administrative proceeding, or the failure
to obtain necessary licenses, could prevent us from developing and commercializing any of our product candidates or a future product candidate, which
could harm our business, financial condition and operating results.
We expect that there are other companies, including major pharmaceutical companies, working in the areas competitive to our product candidates
which either has resulted, or may result, in the filing of patent applications that may be deemed related to our activities. If we were to challenge the validity
of these or any issued United States patent in court, we would need to overcome a statutory presumption of validity that attaches to every issued United
States patent. This means that, in order to prevail, we would have to present clear and convincing evidence as to the invalidity of the patent’s claims. If we
were to challenge the validity of these or any issued United States patent in an administrative trial before the Patent Trial and Appeal Board in the U.S.
PTO, we would have to prove that the claims are unpatentable by a preponderance of the evidence. There is no assurance that a jury and/or court would
find in our favor on questions of infringement, validity or enforceability. Even if we are successful, litigation could result in substantial costs and be a
distraction to management.
31
We may be subject to claims that we have wrongfully hired an employee from a competitor or that we or our employees have wrongfully used
or disclosed alleged confidential information or trade secrets of their former employers. As is commonplace in our industry, we will employ individuals
who were previously employed at other pharmaceutical companies, including our competitors or potential competitors. Although no claims against us are
currently pending, we may be subject in the future to claims that our employees or prospective employees are subject to a continuing obligation to their
former employers (such as non-competition or non-solicitation obligations) or claims that our employees or we have inadvertently or otherwise used or
disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims. Even if we
are successful in defending against these claims, litigation could result in substantial costs and be a distraction to management.
Risks Related to Owning Our Common Stock
The market price of our shares may be subject to fluctuation and volatility. You could lose all or part of your investment. The market price of
our common stock is subject to wide fluctuations in response to various factors, some of which are beyond our control. Since shares of our common stock
were sold in our initial public offering in October 2019 at a price of $5.00 per share, the reported high and low sales prices of our common stock have
ranged from $3.44 to $21.14 through December 31, 2020. The market price of our shares on the NASDAQ Global Market may fluctuate as a result of a
number of factors, some of which are beyond our control, including, but not limited to:
● actual or anticipated variations in our and our competitors’ results of operations and financial condition;
● market acceptance of our product candidates;
● changes in earnings estimates or recommendations by securities analysts, if our shares are covered by analysts;
● development of technological innovations or new competitive products by others;
● announcements of technological innovations or new products by us;
● publication of the results of preclinical or clinical trials for our product candidates;
● failure by us to achieve a publicly announced milestone;
● delays between our expenditures to develop and market new or enhanced products and the generation of sales from those products;
● developments concerning intellectual property rights, including our involvement in litigation brought by or against us;
● regulatory developments and the decisions of regulatory authorities as to the approval or rejection of new or modified products;
● changes in the amounts that we spend to develop, acquire or license new products, technologies or businesses;
● changes in our expenditures to promote our product candidates;
● our sale or proposed sale, or the sale by our significant stockholders, of our shares or other securities in the future;
● changes in key personnel;
● success or failure of our research and development projects or those of our competitors;
● the trading volume of our shares; and
● general economic and market conditions and other factors, including factors unrelated to our operating performance.
These factors and any corresponding price fluctuations may materially and adversely affect the market price of our shares and result in substantial
losses being incurred by our investors. In the past, following periods of market volatility, public company stockholders have often instituted securities class
action litigation. If we were involved in securities litigation, it could impose a substantial cost upon us and divert the resources and attention of our
management from our business.
32
If securities or industry analysts do not continue to publish research or publish inaccurate or unfavorable research about our business, our
stock price and trading volume could decline. The trading market for our common stock depends in part on the research and reports that securities or
industry analysts publish about us or our business. If industry analysts cease coverage of us, the trading price for our common stock would be negatively
affected. If one or more of the analysts who cover us downgrade our common stock or publish inaccurate or unfavorable research about our business, our
common stock price would likely decline. If one or more of these analysts cease coverage of us or fail to publish reports on us regularly, demand for our
common stock could decrease, which might cause our common stock price and trading volume to decline. In addition, independent industry analysts may
provide reviews of our product candidates and our TFF platform’s capabilities, as well as those of our competitors, and perception of our offerings in the
marketplace may be significantly influenced by these reviews. We have no control over what these industry analysts report, and because industry analysts
may influence current and potential customers, our brand could be harmed if they do not provide a positive review of our products and platform capabilities
or view us as a market leader.
Future capital raises may dilute your ownership and/or have other adverse effects on our operations. If we raise additional capital by issuing
equity securities, our existing stockholders’ percentage ownership will be reduced and these stockholders may experience substantial dilution. If we raise
additional funds by issuing debt securities, these debt securities would have rights senior to those of our common stock and the terms of the debt securities
issued could impose significant restrictions on our operations, including liens on our assets. If we raise additional funds through collaborations and
licensing arrangements, we may be required to relinquish some rights to our intellectual property or candidate products, or to grant licenses on terms that
are not favorable to us.
We are an “emerging growth company” under the JOBS Act of 2012 and we cannot be certain if the reduced disclosure requirements
applicable to emerging growth companies will make our common stock less attractive to investors. We are an “emerging growth company,” as defined in
the Jumpstart Our Business Startups Act of 2012, or JOBS Act, and we may take advantage of certain exemptions from various reporting requirements that
are applicable to other public companies that are not “emerging growth companies” including, but not limited to:
● not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act;
● reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements;
● exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden
parachute payments; and
● extended transition periods available for complying with new or revised accounting standards.
We have chosen to take advantage of all of the benefits available under the JOBS Act, including the exemptions discussed above. We cannot
predict if investors will find our common stock less attractive because we may rely on these exemptions. If some investors find our common stock less
attractive as a result, there may be a less active trading market for our common stock and our stock price may be more volatile.
We will remain an “emerging growth company” for up to five years, although we will lose that status sooner if our revenues exceed $1.07 billion,
if we issue more than $1 billion in non-convertible debt in a three year period, or if the market value of our common stock that is held by non-affiliates
exceeds $700 million as of June 30 in any future year.
If we fail to maintain an effective system of internal control over financial reporting, we may not be able to accurately report our financial
results or prevent fraud. Commencing with our annual report on Form 10-K for the fiscal year ended December 31, 2020, we will be required to provide a
report on management’s assessment of our internal control over financial reporting. Once we are neither an emerging growth company nor a non-
accelerated filed, we will be required to obtain an attestation from our independent registered public accounting firm on our internal control report.
Effective internal controls over financial reporting are necessary for us to provide reliable financial reports and, together with adequate disclosure controls
and procedures, are designed to prevent fraud. Any failure to implement required new or improved controls, or difficulties encountered in their
implementation could cause us to fail to meet our reporting obligations. In addition, any testing by us conducted in connection with Section 404 of the
Sarbanes-Oxley Act, or the subsequent testing by our independent registered public accounting firm when required, may reveal deficiencies in our internal
controls over financial reporting that are deemed to be material weaknesses or that may require prospective or retrospective changes to our financial
statements or identify other areas for further attention or improvement. Inferior internal controls could also cause investors to lose confidence in our
reported financial information, which could have a negative effect on the trading price of our common shares. There is also a risk that neither we nor our
independent registered public accounting firm (when applicable in the future) will be able to conclude within the prescribed timeframe that internal controls
over financial reporting is effective as required by Section 404. As a result, investors could lose confidence in our financial and other public reporting,
which would harm our business and the trading price of our common stock.
33
We have not paid dividends in the past and have no immediate plans to pay dividends. We plan to reinvest all of our earnings, to the extent we
have earnings, to cover operating costs and otherwise become and remain competitive. We do not plan to pay any cash dividends with respect to our
securities in the foreseeable future. We cannot assure you that we would, at any time, generate sufficient surplus cash that would be available for
distribution to the holders of our common stock as a dividend. Therefore, you should not expect to receive cash dividends on our common stock.
We may be at an increased risk of securities class action litigation. Historically, securities class action litigation has often been brought against a
company following a decline in the market price of its securities. This risk is especially relevant for us because biotechnology and pharmaceutical
companies have experienced significant stock price volatility in recent years. If we were to be sued, it could result in substantial costs and a diversion of
management’s attention and resources, which could harm our business.
Our charter documents and Delaware law may inhibit a takeover that stockholders consider favorable. The provisions of our second amended
and restated certificate of incorporation, or Certificate, and amended and restated bylaws and applicable provisions of Delaware law may delay or
discourage transactions involving an actual or potential change in control or change in our management, including transactions in which stockholders might
otherwise receive a premium for their shares, or transactions that our stockholders might otherwise deem to be in their best interests. The provisions in our
Certificate and amended and restated bylaws:
● limit who may call stockholder meetings;
● do not provide for cumulative voting rights; and
● provide that all board vacancies may be filled by the affirmative vote of a majority of directors then in office, even if less than a quorum.
In addition, Section 203 of the Delaware General Corporation Law may limit our ability to engage in any business combination with a person who
beneficially owns 15% or more of our outstanding voting stock unless certain conditions are satisfied. This restriction lasts for a period of three years
following the share acquisition. These provisions may have the effect of entrenching our management team and may deprive you of the opportunity to sell
your shares to potential acquirers at a premium over prevailing prices. This potential inability to obtain a control premium could reduce the price of our
common stock.
Our Certificate and amended and restated bylaws designate the Court of Chancery of the State of Delaware as the sole and exclusive forum for
certain litigation that may be initiated by our stockholders, which could limit our stockholders’ ability to obtain a favorable judicial forum for disputes
with us or our directors, officers or other employees. Provisions in our Certificate and amended and restated bylaws provide that the Court of Chancery of
the State of Delaware will, to the fullest extent permitted by law, be the sole and exclusive forum for:
● any derivative action or proceeding brought on our behalf;
● any action asserting a claim of breach of a fiduciary duty owed to us or our stockholders by any of our directors, officers or other employees;
● any action asserting a claim against us or any of our directors, officers or other employees arising pursuant to any provision of Delaware law
or our charter documents; or
● any action asserting a claim against us or any of our directors, officers or other employees governed by the internal affairs doctrine, but
excluding actions to enforce a duty or liability created by the Exchange Act or any other claim for which the federal courts have exclusive
jurisdiction.
These exclusive forum provisions do not apply to claims under the Securities Act or the Exchange Act. These exclusive forums provisions,
however, do provide that if no state court located in the State of Delaware has jurisdiction, the federal district court for the District of Delaware shall be the
exclusive forum. By becoming a stockholder in our company, you will be deemed to have notice of and have consented to the provisions of our Certificate
and amended and restated bylaws related to choice of forum, but will not be deemed to have waived our compliance with the federal securities laws and the
rules and regulations thereunder. The choice of forum provisions in our Certificate and amended and restated bylaws may limit our stockholders’ ability to
obtain a favorable judicial forum for disputes with us or any of our directors, officers or other employees, which may discourage lawsuits with respect to
such claims. Alternatively, if a court were to find the choice of forum provision contained in our Certificate and amended and restated bylaws to be
inapplicable or unenforceable in an action, we may incur additional costs associated with resolving such action in other jurisdictions, which could harm our
business, results of operations and financial condition.
34
Item 1B. Unresolved Staff Comments
Not applicable.
Item 2. Properties
Our former parent, LTI, currently provides us with office space and certain administrative services and equipment for no charge. Those offices are
located at 2600 Via Fortuna, Suite 360 Austin, Texas, 78746; telephone number (737) 802-1975. We also lease 1,500 square feet of office space in
Doylestown, Pennsylvania. The lease agreement is for one year and expires October 31, 2021, subject to our option to renew for an additional year. The
monthly lease rate is $3,000.
Item 3. Legal Proceedings
As of the date of this report, there are no legal proceedings to which we or our properties are subject. We may be involved, from time to time, in
legal proceedings and claims arising in the ordinary course of its business. Such matters are subject to many uncertainties and outcomes and are not
predictable with assurance.
Item 4. Mine Safety Disclosures
Not applicable.
35
PART II
Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Repurchases of Equity Securities
Market Information
Our common stock has traded on the NASDAQ Stock Market under the symbol “TFFP,” since our initial public offering on October 25, 2019.
Since then, our common stock common stock has experienced, and is expected to experience in the future, significant price and volume volatility. The
following table shows the reported high and low closing prices per share for our common stock based on information provided by the NASDAQ Stock
Market for the periods indicated.
Fiscal Year Ended December 31, 2019
Fourth Quarter (commencing on October 25, 2019)
Fiscal Year Ended December 31, 2020
First Quarter
Second Quarter
Third Quarter
Fourth Quarter
Holders of Record
$
$
High
Low
5.40 $
4.71
5.36
6.08
18.47
18.49
3.51
3.79
5.86
12.74
As of March 5, 2021, there were 14 holders of record of our common stock.
Dividend Policy
We have never declared or paid cash dividends on our common stock. We presently intend to retain earnings to finance the operation and
expansion of our business.
Equity Compensation Plan Information
We have adopted the TFF Pharmaceuticals, Inc. 2018 Stock Incentive Plan providing for the grant of non-qualified stock options and incentive
stock options to purchase shares of our common stock and for the grant of restricted and unrestricted share grants. We reserved 3,284,480 shares of our
common stock under the 2018 Plan. All officers, directors, employees and consultants to our company are eligible to participate under the plan. The
purpose of the plan is to provide eligible participants with an opportunity to acquire an ownership interest in our company.
The following table sets forth certain information as of December 31, 2020 about our stock plans under which our equity securities are authorized
for issuance.
(c)
Number of
Securities
Remaining
Available for
Future
Issuance
Under Equity
Compensation
Plans
(Excluding
Securities
Reflected In
Column (a))
673,985
—
673,985
(a)
Number of
Securities to
be Issued
Upon Exercise
of
Outstanding
Options
(b)
Weighted-
Average
Exercise Price
of
Outstanding
Options
2,610,495 $
—
2,610,495 $
36
5.63
—
5.63
Plan Category
Equity compensation plans approved by security holders
Equity compensation plans not approved by security holders
Total
Unregistered Sales of Equity Securities and Use of Proceeds
On August 10, 2020, we entered into a Securities Purchase Agreement, or the Purchase Agreement, and a Registration Rights Agreement with
certain institutional and other accredited investors, pursuant to which the investors purchased 3,048,654 shares of our common stock at a price of $8.50 per
share for the approximate gross proceeds of $25.91 million, before deducting placement agent and other offering expenses. The Purchase Agreement
included customary representations, warranties, and covenants by the investors and us, and an indemnity from us in favor of the investors. Pursuant to the
terms of the Registration Rights Agreement, we filed a resale registration statement with the SEC on September 9, 2020 for purposes of registering the
resale of the shares sold to the investors. The sale of our shares to the investors was exempt under Section 4(a)(2) of the Securities Act of 1933 and Rule
506 there under. All of the investors were accredited investors, as such term is defined in Rule 501 under the Securities Act.
Item 6. Selected Financial Data
Not applicable.
Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations
General
We were formed as a Delaware corporation on January 24, 2018 for the purpose of developing and commercializing innovative drug products
based on our patented Thin Film Freezing, or TFF, technology platform”. Since our formation, we have focused on the development of our initial drug
candidates, the establishment of strategic relationships with established pharmaceutical companies for the licensing of our TFF technology platform and the
pursuit of additional working capital. We have not commenced revenue-producing operations.
Since our organization in 2018, we have engaged in the following financing transactions:
Series A Preferred Stock Placements. In March 2018, we conducted a private placement of 5,662,000 shares of our Series A preferred stock, at an
offering price of $2.50 per share, for the gross proceeds of approximately $14.2 million, and in May 2019 we conducted a private placement of 3,268,000
shares of our Series A preferred stock, at an offering price of $2.50 per share, for the gross proceeds of approximately $8.2 million. The shares of our Series
A preferred stock accumulated dividends at the rate of 6% per annum. The shares of Series A preferred stock, including all accrued but unpaid dividends on
the Series A preferred stock, which totaled $1,603,709, automatically converted into 9,571,692 shares of our common stock concurrent with the completion
of our initial public offering at the conversion price of $2.50.
Initial Public Offering. On October 25, 2019, we conducted an initial public offering of 4,400,000 shares of common stock at a public offering
price of $5.00 per share. After the payment of underwriter discounts and offering expenses, and after giving effect to the underwriters’ exercise of its
overallotment option on November 20, 2019 to purchase an additional 479,300 shares of our common stock at the offering price of $5.00 per share, we
received net proceeds of approximately $21.8 million.
August 2020 Private Placement. On August 13, 2020, we conducted a private placement of 3,048,654 shares of common stock, at a purchase price
per share of $8.50, for aggregate gross proceeds of approximately $25,914,000, before deducting selling commissions and other offering expenses. After
deducting the placement agent and other offering expenses, we received net proceeds of approximately $24,280,000.
Results of Operations
We were formed in January 2018 and have not commenced revenue-producing operations. To date, our operations have consisted of the
development and early-stage testing of our initial product candidates. In connection with our organization on January 24, 2018, we entered into a
Contribution and Subscription Agreement with Lung Therapeutics, Inc., or LTI, our former parent, pursuant to which we agreed to acquire from LTI certain
of LTI’s non-core intellectual property rights and other assets, or the Acquired Assets, all of which relate to our Thin Film Freezing technology. We closed
on the acquisition of the Acquired Assets concurrent with the close of the initial Series A preferred stock financing in March 2018.
In December 2019, the Company established a wholly-owned Australian subsidiary, TFF Pharmaceuticals Australia Pty Ltd. in order to conduct
clinical research.
37
On March 11, 2020, the World Health Organization declared a novel strain of coronavirus disease (“COVID-19”) a global pandemic. We had
expected to commence Phase I clinical trials our TFF formulation of Tacrolimus in Australia in the first quarter of 2020, and on March 13, 2020 we had
received the approval of the Australian Human Research Ethics Committee to commence Phase I trials, however later in March 2020 our contract research
organization in Australia informed us that because of the spread of the COVID-19 virus in Australia, there would be a delay in initiating the trial. During
the second quarter of 2020, we were able to begin dosing in the Phase I Tacrolimus trial in Melbourne, Victoria, Australia. However, due to the resurgence
of COVID-19 in the Melbourne area, in July 2020 the Phase I trials were delayed. With the flaring of COVID-19 in the Melbourne area and in order to
remain dynamic, we opened a second clinical trial site in Brisbane, Queensland, Australia and dosing in the Phase 1 clinical trial resumed in Australia
during the third quarter 2020. We expect that dosing in this trial will be completed early in the second quarter of 2021. Any financial impact cannot be
reasonably estimated at this time, but may materially affect our business and financial condition. The extent to which COVID-19 impacts our results will
depend on future developments, which are highly uncertain and cannot be predicted, including new information which may emerge concerning the severity
of COVID-19 and the actions to contain COVID-19 or treat its impact, among others.
During the fiscal years ended December 31, 2020 and 2019, we incurred $10.7 million and $8.8 million of research and development expenses and
$8.0 million and $3.2 million of general and administrative expenses, respectively. The increase in research and development expenses during 2020 was
due to the ramp-up of research and development activities following the completion of our IPO in October 2019. The ramp up includes our preliminary
analysis and testing of dry powder formulations of certain drugs and vaccines we believe have the potential to become product candidates. We expect our
spending on research and development activities to continue to increase in upcoming quarters. The increase in general and administrative expenses in 2020
from the prior year was mainly a result of public-company related increases in expenses of approximately $1,250,000, increased expenses related to
consulting and business development activities of approximately $1,274,000, payroll and related expense increases of approximately $827,000 and an
increase in stock-based compensation of approximately $1,457,000. While we expect our general and administrative expenses to continue to increase over
the next few years, we anticipate the rate of increase will be less than the increase from 2019 to 2020. We incurred a net loss applicable to common
stockholders of $18.6 million and $36.7 million for the fiscal years ended December 31, 2020 and 2019, respectively. The decrease in net loss applicable to
common stockholders was due to a deemed dividend of $24.0 million upon the conversion of our Series A preferred stock in October 2019.
Financial Condition
As of December 31, 2020, we had total assets of approximately $38.7 million and working capital of approximately $36.2 million. As of
December 31, 2020, our liquidity included approximately $35.3 million of cash and cash equivalents. We believe that our cash on-hand as of the date of
this report is sufficient to fund our proposed operating plan for, at least, the 12 months following the date of this report. However, as of the date of this
report, we believe that we will need additional capital to fund our operations through to the marketing approval for TFF VIP and TFF TIP, assuming such
approval can be obtained at all, and to engage in the substantial development of any other of our drug candidates, such as formulation, early stage animal
testing and formal toxicology studies. If we encounter unforeseen delays or expenses, we have the ability to curtail our presently planned level of
operations. We intend to seek additional funds through various financing sources, including the sale of our equity and debt securities, licensing fees for our
technology and co-development and joint ventures with industry partners, with a preference towards licensing fees for our technology and co-development
and joint ventures with industry partners. In addition, we will consider alternatives to our current business plan that may enable to us to achieve revenue
producing operations and meaningful commercial success with a smaller amount of capital. However, there can be no guarantees that such funds will be
available on commercially reasonable terms, if at all. If such financing is not available on satisfactory terms, we may be unable to further pursue our
business plan and we may be unable to continue operations, in which case you may lose your entire investment.
Cash Flows
The following table sets forth a summary of our cash flows for the years ended December 31, 2020 and 2019:
Year ended
December 31,
2020
Year ended
December 31,
2019
Net cash used in operating activities
Cash used in investing activities
Cash flows provided by financing activities
Effect of exchange rate changes
Net increase in cash and cash equivalents
$ (16,615,589) $ (11,216,122)
-
29,049,387
-
17,833,265
(1,102,808)
24,994,665
(70,399)
7,205,869 $
$
The increase in cash used in operating activities is primarily a result of higher operating losses in 2020 due to our business expansion, including
additional personnel and increased product candidate development activity. The financing activity primarily consists of the October 2019 initial public
offering, or IPO, and the August 2020 private placement.
38
Critical Accounting Policies
Our consolidated financial statements are prepared in accordance with accounting principles generally accepted in the United States of America,
or GAAP. The preparation of our consolidated financial statements and related disclosures requires us to make estimates and judgments that affect the
reported amounts of assets, liabilities, costs and expenses in our consolidated financial statements. We base our estimates on historical experience, known
trends and events and various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making
judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. We evaluate our estimates and assumptions on
an ongoing basis. Our actual results may differ from these estimates under different assumptions or conditions.
While our significant accounting policies are described in more detail in Note 3 to our consolidated financial statements included herein, we
believe that the following accounting policies are those most critical to the judgments and estimates used in the preparation of our consolidated financial
statements.
Stock-Based Compensation
We compute stock-based compensation in accordance with authoritative guidance. We use the Black-Scholes-Merton option-pricing model to
determine the fair value of its stock options. The Black-Scholes-Merton option-pricing model includes various assumptions, including the fair market value
of our common stock, expected life of stock options, the expected volatility and the expected risk-free interest rate, among others. These assumptions
reflect our best estimates, but they involve inherent uncertainties based on market conditions generally outside our control.
As a result, if other assumptions had been used, stock-based compensation cost, as determined in accordance with authoritative guidance, could
have been materially impacted. Furthermore, if we use different assumptions on future grants, stock-based compensation cost could be materially affected
in future periods.
For grants prior to the IPO, the fair value of the common stock was determined by the board of directors based on a variety of factors, including
valuations prepared by third parties, our financial position, the status of our development efforts, the current climate in the marketplace and the prospects of
a liquidity event, among others. For grants after the IPO, we use the closing stock price on the date of grant as the fair value of the common stock.
Research and Development Expenses
In accordance with authoritative guidance, we charge research and development costs to operations as incurred. Research and development
expenses consist of personnel costs for the design, development, testing and enhancement of our technology, and certain other allocated costs, such as
depreciation and other facilities related expenditures.
Common Stock Warrants
We classify as equity any warrants that (i) require physical settlement or net-share settlement or (ii) provides us with a choice of net-cash
settlement or settlement in its own shares (physical settlement or net-share settlement). We classify as assets or liabilities any contracts that (i) require net-
cash settlement (including a requirement to net cash settle the contract if an event occurs and if that event is outside our control), (ii) gives the counterparty
a choice of net-cash settlement or settlement in shares (physical settlement or net-share settlement) or (iii) that contain reset provisions that do not qualify
for the scope exception. We assess classification of its common stock warrants and other freestanding derivatives at each reporting date to determine
whether a change in classification between assets and liabilities is required. Our freestanding derivatives consist of warrants to purchase common stock that
were issued in connection with services provided to us. We evaluated these warrants to assess their proper classification and determined that the common
stock warrants meet the criteria for equity classification in the consolidated balance sheet. Such warrants are measured at fair value, which we determine
using the Black-Scholes-Merton option-pricing model.
39
Beneficial Conversion Feature
On the date of the IPO, the outstanding Series A preferred stock, and related accrued and unpaid dividends, automatically converted into shares of
our common stock. The conversion share calculation was based on the $2.50 initial issuance price for the Series A preferred stock plus any accrued but
unpaid dividends and converted to common stock using a stated divisor conversion price equal to 50% of the IPO price to the public, which was $5.00 per
share. In accordance with relevant accounting literature, since the stated terms of the conversion option did not permit us to compute the additional number
of shares that it would need to issue upon conversion of the Series A preferred stock when the contingent event occurred, we recorded the beneficial
conversion amount as a deemed dividend at the date of the IPO.
Off Balance Sheet Transactions
We do not have any off-balance sheet transactions.
Item 7A. Quantitative and Qualitative Disclosures About Market Risk
Not applicable.
40
Item 8. Financial Statements and Supplementary Data
Index to Consolidated Financial Statements
Report of Independent Registered Public Accounting Firm
Consolidated Balance Sheets as of December 31, 2020 and 2019
Consolidated Statements of Operations for the years ended December 31, 2020 and 2019
Consolidated Statements of Stockholders’ Equity for the years ended December 31, 2020 and 2019
Consolidated Statements of Cash Flows for the years ended December 31, 2020 and 2019
Notes to Consolidated Financial Statements
F-1
F-2
F-3
F-4
F-5
F-6
F-7
REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
To the Shareholders and Board of Directors of
TFF Pharmaceuticals, Inc.
Opinion on the Financial Statements
We have audited the accompanying consolidated balance sheets of TFF Pharmaceuticals, Inc. (the “Company”) as of December 31, 2020 and 2019, the
related consolidated statements of operations, stockholders’ equity and cash flows for each of the two years in the period ended December 31, 2020, and
the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the
financial position of the Company as of December 31, 2020 and 2019, and the results of its operations and its cash flows for each of the two years in the
period ended December 31, 2020, in conformity with accounting principles generally accepted in the United States of America.
Basis for Opinion
These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial
statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States)
(“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules
and regulations of the Securities and Exchange Commission and the PCAOB.
We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain reasonable
assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor
were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of
internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over
financial reporting. Accordingly, we express no such opinion.
Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and
performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in
the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as
evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.
/s/ Marcum LLP
Marcum LLP
We have served as the Company’s auditor since 2018.
New York, NY
March 10, 2021
F-2
TFF PHARMACEUTICALS, INC.
CONSOLIDATED BALANCE SHEETS
ASSETS
Current assets:
Cash and cash equivalents
Prepaid assets and other current assets
Total current assets
Property and equipment, net
Total assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable
Deferred research grant revenue
Total current liabilities
Accrued research and development expense (see Note 5)
Total liabilities
Commitments and contingencies (see Note 4)
Stockholders’ equity:
Common stock; $0.001 par value, 45,000,000 shares authorized; 22,534,874 and 18,450,992 shares issued and
outstanding as of December 31, 2020 and 2019, respectively
Additional paid-in capital
Accumulated other comprehensive loss
Accumulated deficit
Total stockholders’ equity
Total liabilities and stockholders’ equity
December 31, December 31,
2020
2019
$
$
$
35,300,805 $
2,258,229
37,559,034
1,102,808
38,661,842 $
28,094,936
1,092,462
29,187,398
—
29,187,398
1,297,725 $
24,315
1,322,040
—
1,322,040
410,638
—
410,638
1,132,013
1,542,651
22,535
71,648,453
(51,538)
(34,279,648)
37,339,802
38,661,842 $
18,451
43,338,710
—
(15,712,414)
27,644,747
29,187,398
$
The accompanying notes are an integral part of these consolidated financial statements.
F-3
TFF PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
CONSOLIDATED STATEMENTS OF OPERATIONS
Operating expenses:
Research and development
General and administrative
Total operating expenses
Loss from operations
Other income:
Interest income
Total other income
Net loss
Preferred stock dividend
Deemed dividend for beneficial conversion feature of Series A Preferred Stock
Net loss applicable to common stock
Net loss applicable to common stock per share, basic and diluted
Weighted average common shares outstanding, basic and diluted
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
Net loss
Other comprehensive loss:
Foreign currency translation adjustments
Comprehensive loss
Year Ended Year Ended
December 31, December 31,
2020
2019
$
10,681,565 $
8,012,085
18,693,650
8,822,226
3,165,331
11,987,557
(18,693,650)
(11,987,557)
126,416
126,416
117,329
117,329
(18,567,234)
(11,870,228)
—
—
(875,359)
(23,929,751)
$ (18,567,234) $ (36,675,338)
(0.91) $
$
(5.31)
20,425,162
6,904,983
$ (18,567,234) $ (11,870,228)
(51,538)
—
$ (18,618,772) $ (11,870,228)
The accompanying notes are an integral part of these consolidated financial statements.
F-4
TFF PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
FOR THE YEARS ENDED DECEMBER 31, 2020 AND 2019
Balance, January 1, 2019
4,000,000 $
4,000 $
596,724 $
- $
Common Stock
Shares
Amount
Additional
Paid in
Capital
Accumulated
Other
Comprehensive Accumulated
Loss
Total
Stockholders’
Equity
(3,241,462)
Deficit
(3,842,186) $
Issuance of common stock in connection
with IPO, including underwriter’s over-
allotment, net of offering costs and
underwriter’s discount
Stock-based compensation
Dividends on preferred stock
Conversion of Series A Preferred Stock
(including accrued dividends) to
common stock
4,879,300
4,879
21,748,969
-
-
-
590,041
-
(875,359)
-
-
-
-
21,753,848
-
590,041
-
(875,359)
9,571,692
9,572
21,278,335
-
-
21,287,907
Net loss
-
-
-
-
(11,870,228)
(11,870,228)
Balance, December 31, 2019
18,450,992
18,451
43,338,710
-
(15,712,414)
27,644,747
Sale of common stock, net of offering costs
3,048,654
3,048
24,277,235
Issuance of common stock for accrued
research and development expense
Issuance of common stock for stock option
220,666
221
1,131,792
exercises
285,003
285
714,097
Issuance of common stock in connection
with cashless warrant exercises
Stock-based compensation
Foreign currency translation adjustment
Net loss
529,559
530
(530)
-
-
-
-
2,187,149
-
-
-
-
-
-
-
-
-
-
24,280,283
-
1,132,013
-
714,382
-
-
-
2,187,149
(51,538)
-
(51,538)
-
(18,567,234)
(18,567,234)
Balance, December 31, 2020
22,534,874 $
22,535 $
71,648,453 $
(51,538) $ (34,279,648) $
37,339,802
The accompanying notes are an integral part of these consolidated financial statements.
F-5
TFF PHARMACEUTICALS, INC.
CONSOLIDATED STATEMENTS OF CASH FLOWS
Cash flows from operating activities:
Net loss
Adjustment to reconcile net loss to net cash used in operating activities:
Stock based compensation
Changes in operating assets and liabilities:
Prepaid assets
Accounts payable
Deferred research grant revenue
Accrued research and development expense
Net cash used in operating activities
Cash flows from investing activities:
Purchases of property and equipment
Net cash used in investing activities
Cash flows from financing activities:
Net proceeds from issuance of common stock in connection with IPO
Net proceeds from issuance of preferred stock
Net proceeds from issuance of common stock
Proceeds from issuance of common stock for stock option exercises
Net cash provided by financing activities
Effect of exchange rate changes on cash and cash equivalents
Net increase in cash and cash equivalents
Cash and cash equivalents at beginning of year
Cash and cash equivalents at end of year
Supplemental disclosure of non-cash investing and financing activities:
Accrued dividend
Conversion of Series A Preferred Stock (including accrued dividends) to common stock
Offering costs netted with proceeds from IPO
Deemed dividend for beneficial conversion feature of Series A Preferred Stock
Cashless exercise of warrants
Issuance of common stock for accrued research and development expense
Year Ended
December 31,
2020
Year Ended
December 31,
2019
$ (18,567,234) $ (11,870,228)
2,187,149
590,041
(1,122,495)
862,676
24,315
-
(1,080,397)
12,449
-
1,132,013
(16,615,589)
(11,216,122)
(1,102,808)
(1,102,808)
-
-
-
-
24,280,283
714,382
21,851,160
7,198,227
-
-
24,994,665
29,049,387
(70,399)
-
7,205,869
17,833,265
28,094,936
10,261,671
$
35,300,805 $
28,094,936
$
$
$
$
$
$
- $
- $
- $
- $
530 $
1,132,013 $
875,359
21,287,907
97,312
23,929,751
-
-
The accompanying notes are an integral part of these consolidated financial statements.
F-6
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 1 – ORGANIZATION AND DESCRIPTION OF BUSINESS
TFF Pharmaceuticals, Inc. (the “Company”) was incorporated in the State of Delaware on January 24, 2018 by Lung Therapeutics, Inc. (“LTI”), at which
time the Company and LTI entered into a Contribution and Subscription Agreement (“Contribution Agreement”) pursuant to which LTI agreed to transfer
to the Company certain of LTI’s non-core intellectual property rights and other assets, including LTI’s rights under a patent license agreement with the
University of Texas at Austin (see Note 5), in exchange for 4,000,000 shares of the Company’s common stock. The transactions under the Contribution
Agreement closed in March 2018. LTI’s basis in such assets were minimal. LTI is an early-stage biotechnology company focused on the development of
certain technologies in the pulmonary field. The Company’s initial focus is on the development of inhaled dry powder drugs to enhance the treatment of
pulmonary diseases and conditions. In December 2019, the Company established a wholly-owned Australian subsidiary, TFF Pharmaceuticals Australia Pty
Ltd (“TFF Australia”), in order to conduct clinical research. TFF Pharmaceuticals, Inc., along with TFF Australia, are collectively referred to as the
“Company”. The Company is in the development stage and is devoting substantially all of its efforts toward technology research and development.
October 2019 Initial Public Offering
In October 2019, the Company completed an initial public offering (“IPO”), selling 4,400,000 shares of common stock at an offering price of $5.00 per
share. The Company received gross proceeds of approximately $22,000,000. In addition, the Company granted the underwriter a 45-day option to purchase
an additional 660,000 shares of common stock at the initial public offering price, less underwriting discounts and commissions. The option was exercised
in November 2019 and the underwriter purchased an additional 479,300 shares of common stock and the Company received additional gross proceeds of
approximately $2,397,000.
August 2020 Private Placement
On August 13, 2020, the Company conducted a private placement of 3,048,654 shares of its common stock, at a purchase price per share of $8.50, for
aggregate gross proceeds to the Company of approximately $25,914,000, before deducting selling commissions and other offering expenses payable by the
Company. After deducting the placement agent and other offering expenses, the Company received net proceeds of approximately $24,280,000. See Note 6
for additional details of the private placement.
COVID-19
On March 11, 2020, the World Health Organization declared a novel strain of coronavirus disease (“COVID-19”) a global pandemic. At this time, the
United States and certain other countries are the subject of lock-downs and self-isolation procedures, which have significantly limited business operations
and restricted internal and external meetings. The Company had expected to commence Phase I clinical trials of its thin film freezing, or TFF, formulation
of Tacrolimus in Australia in the first quarter of 2020, and on March 13, 2020 the Company received the approval of the Alfred Hospital Human Research
Ethics Committee to commence Phase I trials, however, later in March 2020, the Company’s contract research organization in Australia informed the
Company that because of the spread of the COVID-19 virus in Australia, there would be a delay in initiating the trial. During the second quarter of 2020,
the Company was able to begin dosing in the Phase I Tacrolimus trial in Melbourne, Victoria, Australia. However, due to the resurgence of COVID-19 in
the Melbourne area, in July 2020 the Phase I trials were delayed. With the flaring of COVID-19 in the Melbourne area and in order to remain dynamic, the
Company opened a second clinical trial site in Brisbane, Queensland, Australia. and dosing in the Phase 1 clinical trial resumed in Australia during the
third quarter 2020. We expect that dosing in this trial will be completed early in the second quarter of 2021. Any financial impact from the COVID-19
global pandemic cannot be reasonably estimated at this time, but may materially affect our business and financial condition. The extent to which COVID-
19 impacts our results will depend on future developments, which are highly uncertain and cannot be predicted, including new information which may
emerge concerning the severity of COVID-19 and the actions to contain COVID-19 or treat its impact, among others.
F-7
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 2 – LIQUIDITY AND MANAGEMENT’S PLANS
As of December 31, 2020, the Company had cash and cash equivalents of approximately $35,301,000 and a working capital surplus of approximately
$36,237,000. The Company has not generated revenues since inception and has incurred recurring operating losses. The Company expects to continue
incurring losses for the foreseeable future and may need to raise additional capital to pursue its product development.
The Company expects to further increase its research and development activities, which will increase the amount of cash utilized subsequent to December
31, 2020. Specifically, the Company expects increased spending on research and development activities and higher payroll expenses as it increases its
professional and scientific staff and continues to prepare for anticipated manufacturing activities. If we encounter unforeseen delays or expenses, we have
the ability to curtail our presently planned level of operations. The Company currently believes its existing cash and cash equivalents will be sufficient to
fund its operating expenses and capital expenditure requirements for at least the next 12 months from the date of issuance of these consolidated financial
statements.
NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Basis of Presentation
The Company’s consolidated financial statements are presented in accordance with accounting principles generally accepted in the United States of
America (“GAAP”) and the rules and regulations of the Securities and Exchange Commission (“SEC”) and reflect the financial position, results of
operations and cash flows for all periods presented.
Principles of Consolidation
The consolidated financial statements include the accounts of TFF Pharmaceuticals, Inc. and its wholly-owned subsidiary, TFF Australia. All material
intercompany accounts and transactions have been eliminated in consolidation.
Foreign Currency
The currency of TFF Australia, the Company’s international subsidiary, is in Australian dollars. Foreign currency denominated assets and liabilities are
translated into U.S. dollars using the exchange rates in effect at each balance sheet date. Results of operations and cash flows are translated using the
average exchange rates throughout the period. The effect of exchange rate fluctuations on translation of assets and liabilities is included as a separate
component of stockholders’ equity in accumulated other comprehensive income (loss).
Geographic Concentrations
The Company conducts business in the U.S. and Australia. As of December 31, 2020, the Company maintained 100% of its net property and equipment in
the U.S. There was no property and equipment as of December 31, 2019.
Deferred Offering Costs
The Company complies with the requirements of Accounting Standards Codification (“ASC”) 340, Other Assets and Deferred Costs. Deferred offering
costs of consisted primarily of legal, accounting and filing fees that were related to the Company’s IPO and were charged to capital upon completion of the
IPO in October 2019. There are no deferred offering costs as of December 31, 2020 and 2019.
Cash and Cash Equivalents
The Company maintains its operating accounts in financial institutions in the U.S. and in Australia. The balances are insured up to specified limits. The
Company’s cash is maintained in checking accounts and money market funds with maturities of less than three months when purchased, which are readily
convertible to known amounts of cash, and which in the opinion of management are subject to insignificant risk of loss in value. As of December 31, 2020
and 2019, the Company had cash in Australia of AUD$214,240 (US$165,092) and $0, respectively.
F-8
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES, continued
Property and Equipment
Property and equipment are stated at cost less accumulated depreciation and amortization. The Company calculates depreciation using the straight-line
method over the estimated useful lives of the assets, which range from two to five years for furniture, fixtures, lab and computer equipment and software.
Assets held within construction in progress are not depreciated. Construction in progress is related to the construction or development of property and
equipment that have not yet been placed in service for its intended use. As of December 31, 2020, all of the Company’s property and equipment consist of
lab equipment that are considered construction in progress. Expenditures for repairs and maintenance of assets are charged to expense as incurred.
Fair Value of Financial Instruments
Authoritative guidance requires disclosure of the fair value of financial instruments. The Company’s financial instruments consist of cash and cash
equivalents and accounts payable, the carrying amounts of which approximate their estimated fair values primarily due to the short-term nature of the
instruments or based on information obtained from market sources and management estimates. The Company measures the fair value of certain of its
financial assets and liabilities on a recurring basis. A fair value hierarchy is used to rank the quality and reliability of the information used to determine fair
values. Financial assets and liabilities carried at fair value which is not equivalent to cost will be classified and disclosed in one of the following three
categories:
Level 1 — Quoted prices (unadjusted) in active markets for identical assets and liabilities.
Level 2 — Inputs other than Level 1 that are observable, either directly or indirectly, such as unadjusted quoted prices for similar assets and liabilities,
unadjusted quoted prices in the markets that are not active, or other inputs that are observable or can be corroborated by observable market data for
substantially the full term of the assets or liabilities.
Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.
Income Taxes
In accordance with authoritative guidance, deferred tax assets and liabilities are recorded for temporary differences between the financial reporting and tax
bases of assets and liabilities using the current enacted tax rate expected to be in effect when the differences are expected to reverse. A valuation allowance
is recorded on deferred tax assets unless realization is considered more likely than not.
The Company evaluates its tax positions taken or expected to be taken in the course of preparing the Company’s tax returns to determine whether the tax
positions are “more-likely-than-not” of being sustained by the applicable tax authority. Tax positions not deemed to meet the “more-likely-than-not”
threshold are not recorded as a tax benefit or expense in the current year. The Company recognizes interest and penalties, if any, related to uncertain tax
positions in interest expense. No interest and penalties related to uncertain tax positions were accrued at either December 31, 2020 or 2019.
The Company follows authoritative guidance which requires the evaluation of existing tax positions. The Company files in the federal and various state
jurisdictions. Management has analyzed all open tax years, as defined by the statute of limitations, for all major jurisdictions. Open tax years are those that
are open for examination by taxing authorities. The Company was incorporated during 2018 which is the only open year at this time.
Revenue Recognition
The Company entered into a feasibility and material transfer agreement (“Feasibility Agreement”) with a third party that provided the Company funds in
return for certain research and development activities. Revenue from the Feasibility Agreement will be recognized in the period during which the related
qualifying services are rendered and costs are incurred, provided that the applicable conditions under the Feasibility Agreement have been met.
F-9
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES, continued
The Feasibility Agreement is on a best-effort basis and does not require scientific achievement as a performance obligation. All fees received under the
agreement are non-refundable. The costs associated with the agreement are expensed as incurred and will be reflected as a component of research and
development expense in the accompanying consolidated statements of operations.
Funds received from the Feasibility Agreement will be recorded as revenue as the Company is the principal participant in the arrangement because the
activities under the Feasibility Agreement are part of the Company’s development programs. In those instances where the Company first receives
consideration in advance of providing underlying services, the Company classifies such consideration as deferred revenue until (or as) the Company
provides the underlying services. In those instances where the Company first provides the underlying services prior to its receipt of consideration, the
Company records a grant receivable. As of December 31, 2020 and 2019, the Company had deferred grant revenue of $24,315 and $0, respectively.
Research and Development Expenses
In accordance with authoritative guidance, the Company charges research and development costs to operations as incurred. Research and development
expenses consist of personnel costs for the design, development, testing and enhancement of the Company’s technology, and certain other allocated costs,
such as depreciation and other facilities related expenditures.
Basic and Diluted Earnings per Common Share
Basic net loss per common share is calculated by dividing the net loss by the weighted-average number of common shares outstanding for the period.
Diluted net loss per share is computed by dividing the net loss by the weighted-average number of common shares and dilutive share equivalents
outstanding for the period, determined using the treasury-stock and if-converted methods. Since the Company has had net losses for all periods presented,
all potentially dilutive securities are anti-dilutive. Basic weighted average shares outstanding for the years ended December 31, 2020 and 2019 include
400,000 shares underlying a warrant to purchase common shares. As the shares underlying this warrant can be issued for little consideration (an aggregate
exercise price of $0.01 per share), these shares are deemed to be issued for purposes of basic earnings per share.
For the years ended December 31, 2020 and 2019, the Company had the following potential common stock equivalents outstanding which were not
included in the calculation of diluted net loss per common share because inclusion thereof would be anti-dilutive:
Stock Options
Warrants
Common Stock Warrants
Year Ended Year Ended
December 31,
2019
2,139,078
1,076,463
3,215,541
December 31,
2020
2,610,495
417,355
3,027,850
The Company classifies as equity any warrants that (i) require physical settlement or net-share settlement or (ii) provide the Company with a choice of net-
cash settlement or settlement in its own shares (physical settlement or net-share settlement). The Company classifies as assets or liabilities any contracts
that (i) require net-cash settlement (including a requirement to net cash settle the contract if an event occurs and if that event is outside the Company’s
control), (ii) gives the counterparty a choice of net-cash settlement or settlement in shares (physical settlement or net-share settlement) or (iii) that contain
reset provisions that do not qualify for the scope exception. The Company assesses classification of its common stock warrants and other freestanding
derivatives at each reporting date to determine whether a change in classification between assets and liabilities is required. The Company’s freestanding
derivatives consist of warrants to purchase common stock that were issued in connection with services provided to the Company. The Company evaluated
these warrants to assess their proper classification and determined that the common stock warrants meet the criteria for equity classification in the
consolidated balance sheet. Such warrants are measured at fair value, which the Company determines using the Black-Scholes-Merton option-pricing
model.
F-10
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES, continued
Beneficial Conversion Feature
On the date of the IPO, the outstanding Series A Convertible Preferred Stock (“Series A Preferred Stock”), and related accrued and unpaid dividends,
automatically converted into shares of the Company’s common stock. The conversion share calculation was based on the $2.50 initial issuance price for the
Series A Preferred Stock plus any accrued but unpaid dividends and converted to common stock using a stated divisor conversion price equal to 50% of the
IPO price to the public, which was $5.00 per share. In accordance with relevant accounting literature, since the stated terms of the conversion option did
not permit the Company to compute the additional number of shares that it would need to issue upon conversion of the Series A Preferred Stock when the
contingent event occurred, the Company recorded the beneficial conversion amount of approximately $23,930,000 as a deemed dividend at the date of the
IPO.
Stock-Based Compensation
The Company computes stock-based compensation in accordance with authoritative guidance. The Company uses the Black-Scholes-Merton option-
pricing model to determine the fair value of its stock options. The Black-Scholes-Merton option-pricing model includes various assumptions, including the
fair market value of the common stock of the Company, expected life of stock options, the expected volatility and the expected risk-free interest rate,
among others. These assumptions reflect the Company’s best estimates, but they involve inherent uncertainties based on market conditions generally
outside the control of the Company.
As a result, if other assumptions had been used, stock-based compensation cost, as determined in accordance with authoritative guidance, could have been
materially impacted. Furthermore, if the Company uses different assumptions on future grants, stock-based compensation cost could be materially affected
in future periods.
Use of Estimates
The preparation of consolidated financial statements in conformity with GAAP requires the Company’s management to make estimates and assumptions
that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the
reported amounts of expenses during the reporting period. Significant estimates include the fair value of stock-based compensation and warrants, valuation
allowance against deferred tax assets and related disclosures. Actual results could differ from those estimates.
Recent Accounting Standards
In February 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-02, Leases (Topic 842).
This ASU will require lessees to recognize a right-of-use asset and lease liability on the consolidated balance sheet for leases with terms longer than 12
months. Leases will be classified as either finance or operating, with classification affecting the pattern of expense recognition in the income statement.
ASU No. 2016-02 supersedes the lease accounting requirements of ASC Topic 840, Leases. The Company adopted this standard on January 1, 2020, using
the modified retrospective approach, which did not cause adjustments to prior comparative periods. The new standard provides a number of optional
practical expedients in transition. The Company has elected the following “package of practical expedients” when assessing the transition impact as the
lessee as of January 1, 2020: (1) not to reassess whether any expired or existing contracts, contain leases; (2) not to reassess the lease classification for any
expired or existing leases; and (3) not to reassess initial direct costs for any existing leases. Leases with an initial term of 12 months or less are considered
short-term leases and are not recorded on the balance sheet as the Company recognizes lease expense for these leases on a straight-line basis over the lease
term. The Company reviewed all contracts that may contain leases and has determined that there was no impact related to the adoption of ASU 2016-02 as
the only contract that contains a lease on the adoption date is for office space in Doylestown, Pennsylvania, which is considered a short-term lease. See
Note 4 for more information regarding the leased office space.
F-11
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES, continued
In July 2017, the FASB issued ASU 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480) and Derivatives and
Hedging (Topic 815): I. Accounting for Certain Financial Instruments with Down Round Features; II. Replacement of the Indefinite Deferral for
Mandatorily Redeemable Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope
Exception, (ASU 2017-11). Part I of this update addresses the complexity of accounting for certain financial instruments with down round features. Down
round features are features of certain equity-linked instruments (or embedded features) that result in the strike price being reduced on the basis of the
pricing of future equity offerings. Current accounting guidance creates cost and complexity for entities that issue financial instruments (such as warrants
and convertible instruments) with down round features that require fair value measurement of the entire instrument or conversion option. Part II of this
update addresses the difficulty of navigating Topic 480, Distinguishing Liabilities from Equity, because of the existence of extensive pending content in the
FASB Accounting Standards Codification. This pending content is the result of the indefinite deferral of accounting requirements about mandatorily
redeemable financial instruments of certain nonpublic entities and certain mandatorily redeemable noncontrolling interests. The amendments in Part II of
this update do not have an accounting effect. This guidance is effective for public business entities for fiscal years beginning after December 15, 2018,
including interim periods within those fiscal years, and effective for all other entities for fiscal years beginning after December 15, 2019 and interim
periods within fiscal years beginning after December 15, 2020. The adoption of this standard did not have a material effect on the Company’s consolidated
financial statements.
In June 2018, the FASB issued ASU No. 2018-07, Compensation — Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based
Payment Accounting. The guidance in this ASU expands the scope of ASC Topic 718 to include all share-based payment arrangements related to the
acquisition of goods and services from both nonemployees and employees. This guidance is effective for public business entities for fiscal years beginning
after December 15, 2018, including interim periods within those fiscal years, and effective for all other entities for fiscal years beginning after December
15, 2019 and interim periods within fiscal years beginning after December 15, 2020. The adoption of this standard did not have a material effect on the
Company’s consolidated financial statements.
In August 2018, the FASB issued ASU 2018-13, “Fair Value Measurement (Topic 820), - Disclosure Framework - Changes to the Disclosure Requirements
for Fair Value Measurement,” which makes a number of changes meant to add, modify or remove certain disclosure requirements associated with the
movement amongst or hierarchy associated with Level 1, Level 2 and Level 3 fair value measurements. This guidance is effective for fiscal years, and
interim periods within those fiscal years, beginning after December 15, 2019. The adoption of this standard did not have a material effect on the Company’s
consolidated financial statements.
In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740), Simplifying the Accounting for Income Taxes, which clarifies and simplifies
certain aspects of the accounting for income taxes. The standard is effective for years beginning after December 15, 2020, and interim periods within
annual periods beginning after December 15, 2020. The adoption of this standard on January 1, 2021 is not expected to have a material impact on the
Company’s consolidated financial statements.
In January 2020, the FASB issued ASU 2020-01, Investments – Equity Securities, Investments – Equity Method and Joint Ventures, and Derivatives and
Hedging – Clarifying the Interactions Between Topic 321, Topic 323, and Topic 815, intended to clarify the interactions between ASC 321, ASC 323 and
ASC 815. The new standard addresses accounting for the transition into and out of the equity method and measurement of certain purchased options and
forward contracts to acquire investments. The standard is effective for annual and interim periods beginning after December 15, 2020, with early adoption
permitted. Adoption of the standard requires changes to be made prospectively. The adoption of this standard on January 1, 2021 is not expected to have a
material impact on the Company’s consolidated financial statements.
F-12
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 4 – COMMITMENTS AND CONTINGENCIES
Operating Leases
In October 2018, the Company entered into a lease agreement for office space in Doylestown, Pennsylvania. The lease commenced on October 15, 2018,
the Company exercised a one-year lease renewal in October 2019, and another one-year lease renewal in October 2020 that will expire on October 31,
2021. The lease has an additional one-year option for renewal, and the base rent is $36,000 per year. The Company has determined that the lease agreement
is considered a short-term lease under ASC 842 and has not recorded a right-of-use asset or liability. The Company rents another office space on a month-
to-month basis with no long-term commitment, which is considered a short-term lease as well. Short-term lease expense for the years ended December 31,
2020 and 2019 was approximately $59,000 and $28,000, respectively.
Approximate future minimum lease payments required under the operating lease, as amended, are as follows:
Year ending December 31,
2021
Legal
Amount
$
30,000
The Company may be involved, from time to time, in legal proceedings and claims arising in the ordinary course of its business. Such matters are subject to
many uncertainties and outcomes and are not predictable with assurance. While management believes that such matters are currently insignificant, matters
arising in the ordinary course of business for which the Company is or could become involved in litigation may have a material adverse effect on its
business and financial condition. To the Company’s knowledge, neither the Company nor any of its properties are subject to any pending legal proceedings.
NOTE 5 – LICENSE AND AGREEMENTS
In July 2015, the University of Texas at Austin (“UT”) granted to the Company’s former parent, LTI, an exclusive worldwide, royalty bearing license to the
patent rights for the TFF platform in all fields of use, other than vaccines for which LTI received a non-exclusive worldwide, royalty bearing license to the
patent rights for the TFF platform. In March 2018, LTI completed an assignment to the Company all of its interest to the TFF platform, including the patent
license agreement with UT, at which time the Company paid UT an assignment fee of $100,000 in accordance with the patent license agreement. In
November 2018, the Company and UT entered into an amendment to the patent license agreement pursuant to which, among other things, the Company’s
exclusive patent rights to the TFF platform were expanded to all fields of use. The patent license agreement requires the Company to pay royalties and
milestone payments and conform to a variety of covenants and agreements, and in the event of the Company’s breach of agreement, UT may elect to
terminate the agreement. During the year ended December 31, 2019, the Company achieved one milestone by gaining IND approval on first indication of a
licensed product on November 24, 2019. The milestone fee associated with this achievement to be paid is $50,000 and the Company must issue UT
common shares equal to 1% of the Company’s outstanding shares of common stock, on a fully diluted basis, as of 30 days after IND approval, which was
December 24, 2019. The total amount of common shares due and payable on December 31, 2019 to UT were 220,666 common shares, which have a fair
value of approximately $1,132,000 based on the closing stock price of $5.13 on December 24, 2019. As of December 31, 2019, the Company had not paid
the $50,000 or issued the shares and has included the $50,000 in accounts payable and the share amount due as a research and development expense
payable. The Company paid the $50,000 and issued the shares in January 2020. As of the date of these consolidated financial statements, the Company is in
compliance with the patent license agreement as all required amounts have been paid in accordance with the agreement.
In May 2018, the Company entered into a master services agreement and associated individual study contracts with ITR Canada, Inc. (“ITR”) to provide
initial contract pre-clinical research and development services for the Company’s drug product candidates. The fees payable for pre-clinical research and
development services under these study contracts totaled $1,790,000, with no minimum fee requirement. In January 2019, the Company cancelled all of the
individual study contracts with ITR and entered into a contract with 11036114 Canada Inc. (initially dba VJO Non-Clinical Development and now dba
Strategy Point Innovations (“SPI”)) to complete additional pre-clinical research and development services in order to take advantage of eligible Canadian
Tax Credits. The services related to the contract with SPI were sub-contracted to ITR under substantially the same terms as the initial contract with ITR,
with fees payable for services under statements of work that are currently open totaling $4,582,000, as amended. During the years ended December 31,
2020 and 2019, the Company recorded research and development costs of approximately $1,177,000 and $2,746,000, respectively.
F-13
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 5 – LICENSE AND AGREEMENTS, continued
In April 2019, the Company entered into a master services agreement with Irisys, LLC to provide contract manufacturing services for one of the
Company’s drug product candidates, Voriconazole. The fees payable for open contract manufacturing services under this agreement total approximately
$3,220,000, as amended, with additional pass-through costs. During the years ended December 31, 2020 and 2019, the Company recorded research and
development costs of approximately $1,837,000 and $867,000, respectively.
In June 2019, the Company entered into a master services agreement with CoreRx to provide contract manufacturing services for one of the Company’s
drug product candidates, Tacrolimus. The fees payable for open contract manufacturing services under this agreement total approximately $1,103,000, as
amended, with additional pass-through costs. During the years ended December 31, 2020 and 2019, the Company recorded research and development costs
of approximately $839,000 and $290,000, respectively.
In August 2019, the Company entered into a master services agreement and associated individual study contracts with Conform Clinical Development, Inc.
and its affiliates, Les Entreprises Envie Inc. (dba Envie Ventures) and Desire Ventures LLC, which sub-contracted with Inflamax Research Limited (dba
Cliantha Research) to perform a Phase I study of one of the Company’s drug candidates, Voriconazole. The fees payable for the open services under this
contract total approximately $1,484,000, as amended. During the years ended December 31, 2020 and 2019, the Company recorded research and
development costs of approximately $1,824,000 and $977,000, respectively.
In January 2020, TFF Australia entered into a master consultancy agreement with Novotech (Australia) Pty Ltd. (formally known as Clinical Network
Services Pty Ltd.) to provide initial contract clinical research and development services for the Company’s drug product candidates. The fees payable for
clinical research and development services under these open study contracts totaled AUD$1,942,981 (US$1,355,580), as amended. During the year ended
December 31, 2020, the Company recorded research and development costs of approximately AUD$590,000 (US$407,000).
In May 2020, TFF Australia entered into an amended clinical trial research agreement with Nucleus Network Pty Ltd. to provide a Phase I study of one of
the Company’s drug candidates, Tacrolimus. The fees payable for services under this contract totaled AUD$1,392,805 (US$953,388), as amended. During
the year ended December 31, 2020, the Company recorded research and development costs of approximately AUD$489,000 (US$337,000).
In August 2020, TFF Australia entered into a clinical trial research agreement with Q-Pharm Pty Ltd. to provide a Phase I study of one of the Company’s
drug candidates, Tacrolimus. The fees payable for services under this contract totaled AUD$704,600 (US$505,488). During the year ended December 31,
2020, the Company recorded research and development costs of approximately AUD$557,000 (US$384,000).
On August 12, 2020, the Company entered into a licensing and collaboration agreement with UNION therapeutics A/S in which UNION acquired an
option to obtain a worldwide exclusive license for the TFF technology in combination with niclosamide. Pursuant to the terms of the license agreement,
UNION can exercise its option to obtain the license within 45 days after the complete data has been received by UNION from investigator-initiated trials.
Upon exercise of the option, UNION shall be responsible to pay all expenses incurred in the development of any licensed product. The Company will be
eligible to receive milestone payments upon the achievement of certain milestones in the development the licensed products, based on completion of
clinical trials, pre-marketing approvals and/or the receipt of at least $25,000,000 of grant funding. The Company will receive a single-digit tiered royalty on
net sales. The Company will also be entitled to receive sales-related milestone payments based on the commercial success of the licensed products.
F-14
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 6 – STOCKHOLDERS’ EQUITY
Common Stock
IPO
In October 2019, the Company completed an IPO, selling 4,400,000 shares of common stock at an offering price of $5.00 per share. The Company received
gross proceeds of approximately $22,000,000. In addition, the Company granted the underwriter a 45-day option to purchase an additional 660,000 shares
of common stock at the initial public offering price. The option was exercised and the underwriter purchased an additional 479,300 shares of common stock
and the Company received additional gross proceeds of approximately $2,397,000. The Company received net proceeds from the IPO and the underwriter’s
purchase of additional shares of approximately $21,754,000, after deducting underwriting discounts and commissions and offering-related expenses.
Warrants for 317,155 shares of the Company’s common stock were issued to the IPO underwriter at an exercise price of $6.25 per share as part of the
underwriter’s compensation for the IPO. The estimated fair value of the warrants of approximately $977,000 was considered an offering cost and netted
against additional paid-in capital.
In conjunction with the IPO, the Company’s outstanding shares of Series A Preferred Stock automatically converted into 9,571,692 shares of its common
stock (see below). Also in conjunction with the issuance of shares in the IPO, the Company granted options to officers and directors to purchase 627,984
shares of common stock at an exercise price of $5.00.
UT Agreement
In November 2019, the Company achieved a milestone in connection with the UT agreement (see Note 5). As a result of the milestone, the Company owed
UT 220,666 shares of common stock, which had a fair value of approximately $1,132,000, which was accrued in accrued research and development
expense as of December 31, 2019. In January 2020, the Company issued the 220,666 shares of common stock to UT.
August 2020 Private Placement
On August 10, 2020, the Company entered into a Securities Purchase Agreement (the “Purchase Agreement”) and a Registration Rights Agreement (the
“Registration Rights Agreement”) with certain institutional and other accredited investors pursuant to which the Company issued and sold to the investors
3,048,654 shares of the Company’s common stock at a price of $8.50 per share for gross proceeds of approximately $25.91 million, before deducting
placement agent and other offering expenses. After deducting the placement agent and other offering expenses, the Company received net proceeds of
approximately $24.28 million. The Purchase Agreement included customary representations, warranties, and covenants by the investors and the Company,
and an indemnity from the Company in favor of the investors. Jefferies LLC acted as placement agent for the private placement and the private placement
closed on August 13, 2020. Pursuant to the terms of the Registration Rights Agreement, the Company filed a resale registration statement on Form S-1 with
the SEC that was declared effective on September 15, 2020.
Stock Option Exercises
During November and December 2020, 285,003 shares of common stock were issued in connection with the exercise of stock options for total proceeds of
$714,382.
Cashless Warrant Exercises
During August through December 2020, 529,559 shares of common stock were issued in connection with the cashless exercise of 659,108 common stock
warrants.
Series A Convertible Preferred Stock
Prior to our initial public offering in October 2019, the Company’s amended and restated certificate of incorporation authorized the Company to issue up to
10,000,000 shares of preferred stock, all of which was designated as Series A preferred stock and there were 8,930,000 shares of Series A preferred stock
issued and outstanding immediately prior to the Company’s initial public offering. Pursuant to the Company’s amended and restated certificate of
incorporation, all outstanding shares of Series A preferred stock automatically converted to common stock at the close of our initial public offering and
thereafter the Company was no longer authorized to issue any preferred stock.
The Series A Preferred Stock ranked senior to common stock with respect to dividends rights and liquidation preferences and had full voting rights. The
Series A Preferred Stock accrued a dividend at a rate of 6% per annum, and $875,359 of dividends accrued during the year ended December 31, 2019.
F-15
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 6 – STOCKHOLDERS’ EQUITY (DEFICIT), continued
Pursuant to the Company’s amended and restated certificate of incorporation, holders of the Series A Preferred Stock had the following methods of
conversion: (i) automatic conversion into common stock upon the consummation of an IPO at a conversion price of 50% of the IPO price, (ii) automatic
conversion into common stock upon the consummation of a subsequent private placement of securities at a conversion price of 50% of the purchase price
of the securities being sold by the Company approved by the holders of the Series A preferred stock, and (iii) at any time after the issuance date and until
ten calendar days prior to the consummation of an IPO, each holder shall be entitled to convert into common stock at a conversion price of $2.50 per share.
The Series A Preferred Stock automatically converted into 9,571,692 common shares upon completion of the IPO in October 2019, based on the number of
shares of Series A Preferred Stock outstanding as of the date of the IPO. The conversion share calculation was based on the $2.50 initial issue price for the
Series A Preferred Stock plus $1,603,709 of accrued and unpaid dividends and automatically converted into shares of the Company’s common stock using
a stated divisor conversion price equal to 50% of the IPO price to the public which was $5.00 per share. In accordance with relevant accounting literature,
since the terms of the conversion option did not permit the Company to compute the additional number of shares that it would need to issue upon
conversion of the Series A Preferred when the contingent event occurred, the Company recorded the beneficial conversion amount of approximately
$23,930,000 as a deemed dividend at the date of the IPO.
2019 Private Placement
In May 2019, the Company entered into a securities purchase agreement with various accredited investors to raise gross proceeds of $8.2 million in a
private placement (the “2019 Private Placement”), issuing 3,268,000 shares of its Series A Preferred Stock. The shares of the Series A Preferred Stock were
sold for $2.50 per share. The Company received net proceeds of approximately $7.2 million from the 2019 Private Placement, after paying placement agent
fees and offering expenses.
NOTE 7 – WARRANTS
On March 13, 2018 and March 22, 2018, the Company issued to National Securities Corporation warrants to purchase shares of the Company’s common
stock in an amount equal to 10% of the shares of common stock issuable upon conversion of 5,662,000 shares of the Company’s Series A Preferred Stock.
In connection with the conversion of the Series A Preferred Stock as a result of the IPO, the Company issued additional warrants to purchase 53,679 shares
of common stock. The additional warrants were considered offering costs and netted with the proceeds from the IPO.
On May 16, 2019 and May 23, 2019, the Company issued to National Securities Corporation 326,800 warrants to purchase shares of the Company’s
common stock. The fair value of the warrants on the grant date was estimated using the Black-Scholes-Merton option pricing model with a common stock
value of $1.67 per share, a contractual life of 5 years, a dividend yield of 0%, a volatility of 89.6% and an assumed risk-free interest rate of 2.11%. The fair
value of the warrants was determined to be approximately $347,000 and was included in general and administrative expenses in the statement of
operations. On September 13, 2019, these warrants were cancelled by the individual warrant holders and the Company determined that the related expense
should be reversed. The reversal of the expense was recorded during the three months ended September 30, 2019, when the warrants were cancelled.
F-16
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 7 – WARRANTS, continued
On October 29, 2019, the Company issued a ten-year warrant to purchase 43,794 shares of common stock at $5.00 per share to BP Directors, LP (“BP”).
The warrant represented consideration for board service from Dr. Aaron Fletcher. The fair value of the warrant on the grant date was estimated using the
Black-Scholes-Merton option pricing model with a common stock value of $5.01 per share, a contractual life of 6.0 years, a dividend yield of 0%, a
volatility of 88.48% and an assumed risk-free interest rate of 1.70%. The warrant is subject to a 25% cliff vesting at one year from the date of grant and the
balance vesting quarterly over the following two years. The fair value of the warrant was determined to be $161,419 and is being amortized in general and
administrative expenses in the consolidated statements of operations over the vesting term.
On November 26, 2019, the Company issued to National Securities Corporation and its representatives underwriter warrants to purchase 317,155 shares of
the Company’s common stock in connection with the IPO. The exercise price of the warrants is $6.25 per share, each has a contractual life of 5 years and
they were not exercisable for one year from the date of grant.
On November 29, 2019, the Company issued a ten-year warrant to purchase 3,623 shares of common stock at $5.00 per share to BP. The warrant
represented consideration for board service from Dr. Aaron Fletcher. The fair value of the warrant on the grant date was estimated using the Black-Scholes-
Merton option pricing model with a common stock value of $5.26 per share, a contractual life of 6.0 years, a dividend yield of 0%, a volatility of 90.16%
and an assumed risk-free interest rate of 1.68%. The warrant is subject to a 25% cliff vesting at one year from the date of grant and the balance vesting
quarterly over the following two years. The fair value of the warrant was determined to be $14,300 and is being amortized in general and administrative
expenses in the consolidated statements of operations over the vesting term.
In determining the fair value for warrants, the expected life of the Company’s warrants was determined using the contractual life. The methodology in
determining all other inputs to calculate the fair value utilizing the Black-Scholes-Merton option pricing model is the same as the stock option methodology
described in Note 8 for stock options.
A summary of warrant activity for the years ended December 31, 2020 and 2019 is as follows:
Outstanding at January 1, 2019
Issued
Cancelled
Outstanding at December 31, 2019
Exercised
Outstanding at December 31, 2020
Number of
Shares
Range of
Exercise
Prices
1,058,212 $ 0.01 – $2.50 $
1.67 – 6.25
745,051
2.50
(326,800)
0.01 – 6.25
1,476,463
(659,108)
2.50 – 6.25
817,355 $ 0.01 – $6.25 $
Weighted-
Average
Exercise
Prices
Weighted-
Average
Remaining
Life
1.56
4.26
2.50
2.71
2.75
2.68
4.6
—
—
4.1
—
3.7
The warrants outstanding at December 31, 2020 had an aggregate intrinsic value of approximately $9,511,000.
NOTE 8 – STOCK BASED COMPENSATION
In January 2018, the Company’s board of directors approved its 2018 Stock Incentive Plan (“2018 Plan”). The 2018 Plan provides for the grant of non-
qualified stock options and incentive stock options to purchase shares of the Company’s common stock, the grant of restricted and unrestricted share
awards and grant of restricted stock units. The Company initially reserved 1,630,000 shares of its common stock under the 2018 Plan; however, upon
completion of the Company’s IPO the number of shares reserved for issuance under the 2018 Plan increased to 3,284,480, representing 15% of the
Company’s outstanding shares of common stock calculated on a fully diluted basis upon the close of the IPO. All of the Company’s employees and any
subsidiary employees (including officers and directors who are also employees), as well as all of the Company’s nonemployee directors and other
consultants, advisors and other persons who provide services to the Company will be eligible to receive incentive awards under the 2018 Plan.
F-17
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 8 – STOCK BASED COMPENSATION, continued
The following table summarizes the stock-based compensation expense recorded in the Company’s results of operations during the years ended December
31, 2020 and 2019 for stock options and warrants:
Research and development
General and administrative
Year Ended Year Ended
December 31,
2020
December 31,
2020
$
$
140,278 $
2,046,871
2,187,149 $
—
590,041
590,041
As of December 31, 2020, there was approximately $9,074,000 of total unrecognized compensation expense related to non-vested share-based
compensation arrangements that are expected to vest. This cost is expected to be recognized over a weighted-average period of 2.4 years.
The Company records compensation expense for employee awards with graded vesting using the straight-line method. The Company records compensation
expense for nonemployee awards with graded vesting using the accelerated expense attribution method. The Company recognizes compensation expense
over the requisite service period applicable to each individual award, which generally equals the vesting term. The Company estimates the fair value of
each option award using the Black-Scholes-Merton option pricing model. Forfeitures are recognized when realized.
The Company estimated the fair value of employee and non-employee stock options using the Black-Scholes option pricing model. The fair value of
employee stock options is being amortized on a straight-line basis over the requisite service periods of the respective awards. The fair value of stock
options issued was estimated using the following assumptions:
Weighted average exercise price
Weighted average grant date fair value
Assumptions
Expected volatility
Expected term (in years)
Risk-free interest rate
Expected dividend yield
Year Ended
December 31,
2020
Year Ended
December 31,
2019
$
$
10.42
9.25
$
$
4.42
3.08
87-91%
6.3-10
0.36-1.47%
0.00%
88-90%
6.3
1.68-2.31%
0.00%
The risk-free interest rate was obtained from U.S. Treasury rates for the applicable periods. The Company’s expected volatility was based upon the
historical volatility for industry peers and used an average of those volatilities. The expected life of the Company’s options was determined using the
simplified method as a result of limited historical data regarding the Company’s activity for employee awards and the contractual term for nonemployee
awards. The dividend yield considers that the Company has not historically paid dividends, and does not expect to pay dividends in the foreseeable future.
For grants prior to the IPO, the fair value of the common stock was determined by the board of directors based on a variety of factors, including valuations
prepared by third parties, the Company’s financial position, the status of development efforts within the Company, the current climate in the marketplace
and the prospects of a liquidity event, among others. For grants after the IPO, the Company uses the closing stock price on the date of grant as the fair value
of the common stock.
F-18
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 8 – STOCK BASED COMPENSATION, continued
The following table summarizes stock option activity during the years ended December 31, 2020 and 2019:
Outstanding at January 1, 2019
Granted
Outstanding at December 31, 2019
Granted
Exercised
Cancelled
Outstanding at December 31, 2020
Exercisable at December 31, 2020
NOTE 9 – INCOME TAXES
Weighted-
Average
Remaining
Contractual
Term
(In Years)
Weighted-
Average
Exercise
Prices
2.50
4.42
3.46
10.42
2.74
4.86
5.63
3.25
9.64 $
—
9.17 $
—
—
—
8.60 $
8.04 $
Intrinsic
Value
—
—
4,052,512
—
—
—
22,789,233
8,365,946
Number of
Shares
1,073,082 $
1,065,996
2,139,078 $
782,045
(285,003)
(25,625)
2,610,495 $
755,885 $
The Company had no income tax expense due to operating losses incurred for the years ended December 31, 2020 and 2019. The Company accounts for
income taxes in accordance with ASC 740, which requires that the tax benefit of net operating losses, temporary differences and credit carryforwards be
recorded as an asset to the extent that management assesses that realization is “more likely than not.” Realization of the future tax benefits is dependent on
the Company’s ability to generate sufficient taxable income within the carryforward period. Because of the Company’s recent history of operating losses,
management believes that recognition of the deferred tax assets arising from the above-mentioned future tax benefits is currently not likely to be realized
and, accordingly, has provided a full valuation allowance.
The Company’s income tax expense for the years ended December 31, 2020 and 2019 are summarized below:
Current:
Federal
State
Foreign
Total current
Deferred:
Federal
State
Foreign
Change in valuation allowance
Total deferred
Income tax provision (benefit)
F-19
December 31,
2020
December 31,
2019
$
$
$
$
- $
-
-
- $
-
-
-
-
(4,502,016) $
-
(480,666)
4,982,682
-
- $
(2,952,519)
-
-
2,952,519
-
-
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 9 – INCOME TAXES, continued
The Company’s deferred tax assets are as follows:
Deferred tax assets:
Net operating loss carryforwards
Research and development tax credit
Intangibles
Stock compensation
Total deferred tax assets
Valuation allowances
Net deferred tax assets
December 31,
2020
December 31,
2019
$
6,807,300 $
1,092,345
136,226
761,741
8,797,612
2,789,541
532,711
105,580
387,098
3,814,930
(8,797,612)
(3,814,930)
$
- $
-
The effective tax rate of the Company’s provision (benefit) for income taxes differs from the federal statutory rate as follows:
Statutory rate
State rate
Foreign
Permanent book/tax differences
Research and development credit
Changes in valuation allowance
Total
December 31,
2020
December 31,
2019
21.00%
0.00%
(1.81)%
(0.26)%
5.09%
(24.02)%
21.00%
0.00%
0.00%
(0.12)%
3.99%
(24.87)%
-
-
As of December 31, 2020 and 2019, the Company had gross federal income tax net operating loss (“NOL”) carryforwards of $30,126,830 and $13,283,530,
respectively, and federal research tax credits of $1,486,704 and $690,525, respectively. Additionally, the Company had gross foreign income tax net
operating loss carryforwards of $1,602,220 as of December 31, 2020. The federal and foreign NOL have an indefinite life while the federal research tax
credits will expire by 2040.
Utilization of U.S. net operating losses and tax credit carryforwards may be limited by “ownership change” rules, as defined in Sections 382 and 383 of the
Code. Similar rules may apply under state tax laws. The Company has not conducted a study to-date to assess whether a limitation would apply under
Sections 382 and 383 of the Code as and when it starts utilizing its net operating losses and tax credits. The Company will continue to monitor activities in
the future. In the event the Company previously experienced an ownership change, or should experience an ownership change in the future, the amount of
net operating losses and research and development credit carryovers available in any taxable year could be limited and may expire unutilized.
F-20
TFF PHARMACEUTICALS, INC.
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
For The Years Ended December 31, 2020 and 2019
NOTE 9 – INCOME TAXES, continued
The CARES Act was signed into law on March 27, 2020 as a response to the economic challenges facing U.S. businesses caused by the COVID-19 global
pandemic. The CARES Act allowed net operating loss incurred in 2018-2020 to be carried back five years or carried forward indefinitely, and to be fully
utilized without being subjected to the 80% taxable income limitation. Net operating losses incurred after December 31, 2020 will be subjected to the 80%
taxable income limitation. In assessing the realization of deferred tax assets, management considers whether it is more likely than not that some portion, or
all, of the deferred tax asset will be realized. The ultimate realization of deferred tax assets is dependent upon the Company attaining future taxable income
during periods in which those temporary differences become deductible.
Due to the uncertainty surrounding the realization of the benefits of its deferred assets, including NOL carryforwards, the Company has provided a 100%
valuation allowance on its deferred tax assets at December 31, 2020.
The Company accounts for uncertain tax positions in accordance with the provisions of ASC 740, Income Taxes. When uncertain tax positions exist, the
Company recognizes the tax benefit of tax positions to the extent that the benefit will more likely than not be realized. The determination as to whether the
tax benefit will more likely than not be realized is based upon the technical merits of the tax position as well as consideration of the available facts and
circumstances. As of December 31, 2020, the Company had a reserve for uncertain tax positions of $394,358, and no interest or penalties have been
charged to the Company for the years ended December 31, 2020 and 2019. If incurred, the Company will classify any interest and penalties as a component
of interest expense and operating expense, respectively. If recognized, $394,358 of the reserve for uncertain tax positions would favorably affect the
Company’s effective tax rate.
A reconciliation of the change in the unrecognized tax positions for the year ended December 31, 2020 is as follows:
Balance at December 31, 2019
Additions for tax positions related to current year
Decreases for tax positions related to prior years
Balance at December 31, 2020
NOTE 10 – SUBSEQUENT EVENTS
Federal and
State
$
$
157,814
318,374
(81,830)
394,358
The Company has performed an evaluation of events occurring subsequent to December 31, 2020 through the filing date of this Annual Report. Based on
its evaluation, nothing other than the events described below need to be disclosed.
Between January 1, 2021 and March 10, 2021, 444,751 shares of common stock were issued in connection with the exercise of warrants and 160,275
shares of common stock were issued in connection with the exercise of stock options. The Company received total cash proceeds from the exercises of
$585,700.
F-21
Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
Not applicable.
Item 9A. Controls and Procedures
(a) Evaluation of Disclosure Controls and Procedures.
Our management, with the participation of our chief executive officer and chief financial officer evaluated the effectiveness of our disclosure
controls and procedures pursuant to Rule 13a-15(e) and 15d-15(e) under the Exchange Act. Based upon that evaluation, our management, including our
chief executive officer and chief financial officer, concluded that our disclosure controls and procedures were effective as of December 31, 2020 in
ensuring all material information required to be filed has been made known in a timely manner.
(b) Changes in internal control over financial reporting.
There were no changes to our internal control over financial reporting, as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act that
occurred during the quarter ended December 31, 2020 that have materially affected, or are reasonably likely to materially affect, our internal control over
financial reporting.
(c) Management’s report on internal controls over financial reporting.
Our management is responsible for establishing and maintaining adequate internal controls over financial reporting, as defined under Rule 15a-
15(f) under the Exchange Act. Our management has assessed the effectiveness of our internal controls over financial reporting as of December 31, 2020
based on the framework established in Internal Control - Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission (2013 Framework) (“COSO”). Our internal control system was designed to provide reasonable assurance to our management and board of
directors regarding the preparation and fair presentation of published financial statements. An internal control material weakness is a significant deficiency,
or aggregation of deficiencies, that does not reduce to a relatively low level the risk that material misstatements in financial statements will be prevented or
detected on a timely basis by employees in the normal course of their work. Our management assessed the effectiveness of our internal control over
financial reporting as of December 31, 2020, and based on that evaluation, management concluded that our internal control over financial reporting was
effective as of December 31, 2020.
This report does not include an attestation report of our registered public accounting firm regarding internal control over financial reporting.
Management’s report was not subject to attestation by our registered public accounting firm pursuant to the rules of the Securities and Exchange
Commission that permit us to provide only management’s report in this Annual Report.
Item 9B. Other Information
Not applicable.
41
The information required by Part III is omitted from this report because we will file a definitive proxy statement within 120 days after the end of
our 2020 fiscal year pursuant to Regulation 14A for our 2020 Annual Meeting of Stockholders, or the 2020 Proxy Statement, and the information to be
included in the 2021 Proxy Statement is incorporated herein by reference.
PART III
Item 10. Directors, Executive Officers and Corporate Governance
The information required by this item will be contained in the 2021 Proxy Statement and is hereby incorporated by reference.
Item 11. Executive Compensation
The information required by this item will be contained in the 2021 Proxy Statement and is hereby incorporated by reference.
Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
The information required by this item will be contained in the 2021 Proxy Statement and is hereby incorporated by reference.
Item 13. Certain Relationships and Related Transactions, and Director Independence
The information required by this item will be contained in the 2021 Proxy Statement and is hereby incorporated by reference.
Item 14. Principal Accountant Fees and Services
The information required by this item will be contained in the 2021 Proxy Statement and is hereby incorporated by reference.
42
Item 15. Exhibits and Financial Statement Schedules
(a) Financial statements
PART IV
Reference is made to the Index and Financial Statements under Item 8 in Part II hereof where these documents are listed.
(b) Financial statement schedules
Financial statement schedules are either not required or the required information is included in the consolidated financial statements or notes
thereto filed under Item 8 in Part II hereof.
(c) Exhibits
The exhibits to this Annual Report on Form 10-K are set forth below. The exhibit index indicates each management contract or compensatory plan
or arrangement required to be filed as an exhibit.
Number
3.1
3.2
4.1
4.2
4.3
4.4
10.1
Exhibit Description
Second Amended and Restated Certificate of Incorporation of the
Registrant
Method of Filing
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
Amended and Restated Bylaws of the Registrant
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
Specimen Certificate representing shares of common stock of
Registrant
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on September 27, 2019.
Warrant dated October 29, 2019 issued to National Securities
Corporation
Incorporated by reference from the Registrant’s Annual Report on
Form 10-K filed on March 27, 2020.
Warrant dated November 20, 2019 issued to National Securities
Corporation
Incorporated by reference from the Registrant’s Annual Report on
Form 10-K filed on March 27, 2020.
Description of Capital Stock
Filed electronically herewith.
Patent License Agreement dated July 8, 2015 between Lung
Therapeutics, Inc. and The University of Texas at Austin
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
10.2*
TFF Pharmaceuticals, Inc. 2018 Stock Incentive Plan
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
10.3*
10.4*
Amended and Restated Consulting Agreement dated December 20,
2018 between Robert Mills and the Registrant
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
Consulting Agreement effective as of January 24, 2018 between Dr.
Brian Windsor and the Registrant, as amended on December 20, 2018
and September 26, 2019
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on September 27, 2019
10.5
Lease Agreement dated October 19, 2018
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
10.6*
10.7
Executive Employment Agreement dated December 20, 2018
between Glenn Mattes and the Registrant
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
Amendment No. 1 to Patent License Agreement dated November 30,
2018 between the Registrant and The University of Texas at Austin
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
43
Number
10.8*
Exhibit Description
Employment Agreement dated February 15, 2019, by and between
the Registrant and Kirk Coleman
Method of Filing
Incorporated by reference from the Registrant’s Registration
Statement on Form S-1 filed on August 20, 2019.
10.9
10.10
10.11*
21.1
23.1
31.1
31.2
32.1
Form of Registration Rights Agreement dated August 10, 2020
between the Company and investors named therein
Incorporated by reference from the Registrant’s Current Report on
Form 8-K filed on August 11, 2020
Amendment No. 1 Dated May 14, 2020 to Executive Employment
Agreement Between Glenn Mattes and Registrant
Incorporated by reference from the Registrant’s Quarterly Report on
Form 10-Q filed on August 13, 2020.
Employment Agreement dated September 24, 2020 by and between
the Registrant and Christopher Cano
Filed electronically herewith.
List of Subsidiaries
Incorporated by reference from the Registrant’s Annual Report on
Form 10-K filed on March 27, 2020.
Consent of Marcum LLP
Filed electronically herewith
Certification under Section 302 of the Sarbanes-Oxley Act of 2002.
Filed electronically herewith.
Certification under Section 302 of the Sarbanes-Oxley Act of 2002.
Filed electronically herewith.
Certifications Pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, 18 U.S.C. Section 1350.
Filed electronically herewith.
101.INS
XBRL Instance Document
Filed electronically herewith
101.SCH
XBRL Taxonomy Extension Schema Document
Filed electronically herewith
101.CAL
XBRL Taxonomy Extension Calculation Linkbase Document
Filed electronically herewith
101.LAB
XBRL Taxonomy Extension Label Linkbase Document
Filed electronically herewith
101.PRE
XBRL Taxonomy Extension Presentation Linkbase Document
Filed electronically herewith
101.DEF
XBRL Taxonomy Extension Definition Linkbase Document
Filed electronically herewith
*
Indicates management compensatory plan, contract or arrangement.
44
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this annual report on Form 10-K
to be signed on its behalf by the undersigned, thereunto duly authorized.
SIGNATURES
Date: March 10, 2021
TFF PHARMACEUTICALS, INC.
By:
/s/ Glenn Mattes
Glenn Mattes,
Chief Executive Officer
Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant
and in the capacities and on the dates indicated.
Signature
/s/ Glenn Mattes
Glenn Mattes
/s/ Kirk Coleman
Kirk Coleman
/s/ Aaron Fletcher
Aaron Fletcher, Ph. D
/s/ Brian Windsor
Brian Windsor, Ph. D
/s/ Robert S. Mills, Jr.
Robert S. Mills, Jr.
/s/ Stephen Rocamboli
Stephen Rocamboli
/s/ Harlan Weisman, M.D.
Harlan Weisman, M.D.
/s/ Randy Thurman
Randy Thurman
/s/ Malcolm Fairbairn
Malcolm Fairbairn
Title
Chief Executive Officer and Director
(Principal Executive Officer)
Chief Financial Officer
(Principal Financial and Accounting Officer)
Date
March 10, 2021
March 10, 2021
Chairman of the Board
March 10, 2021
Director
Director
Director
Director
Director
Director
45
March 10, 2021
March 10, 2021
March 10, 2021
March 10, 2021
March 10, 2021
March 10, 2021
DESCRIPTION OF THE CAPITAL STOCK
EXHIBIT 4.4
TFF Pharmaceuticals, Inc. (“Company”, “we”, “us” and “our”) has one class of securities registered under Section 12 of the Securities Exchange
Act of 1934, as amended, namely our common stock, par value $0.001 per share.
The following is a summary of the rights of our common and of certain provisions of our Second Amended and Restated Certificate of
Incorporation (“Certificate of Incorporation”) and Amended and Restated Bylaws (“Bylaws”). For more detailed information, please see our Certificate of
Incorporation and Bylaws, which are incorporated by reference as exhibits to the Annual Report on Form 10-K to which this description is an exhibit.
Common Stock
Our Certificate of Incorporation authorizes us to issue up to 45,000,000 shares of common stock, $0.001 par value per share. As of March [●],
2021, we had 23,063,491 shares of common stock outstanding, held by [●] stockholders of record.
Holders of shares of common stock are entitled to one vote per share on all matters to be voted upon by the stockholders generally. Stockholders
are entitled to receive such dividends as may be declared from time to time by the Board out of funds legally available therefore, and in the event of
liquidation, dissolution or winding up of the company to share ratably in all assets remaining after payment of liabilities. The holders of shares of common
stock have no preemptive, conversion, subscription rights or cumulative voting rights.
Preferred Stock
Prior to our initial public offering in October 2019, our Certificate of Incorporation authorized us to issue up to 10,000,000 shares of preferred
stock, all of which was designated as Series A preferred stock and there were 8,930,000 shares of Series A preferred stock issued and outstanding
immediately prior to our initial public offering. Pursuant to our Certificate of Incorporation, all outstanding shares of Series A preferred stock automatically
converted to common stock at the close of our initial public offering and thereafter we were no longer authorized to issue any preferred stock.
Dividends
We have never paid cash dividends on our common stock and we do not anticipate the payment of cash dividends on our common stock in the
foreseeable future.
Anti-Takeover Effects of Certain Provisions of Delaware Law
We are subject to the provisions of Section 203 of the Delaware General Corporation Law, or DGCL, an anti-takeover law. In general, Section 203
prohibits a publicly held Delaware corporation from engaging in a “business combination’’ with an “interested stockholder’’ for a period of three years
after the date of the transaction in which such stockholder became an interested stockholder, unless the business combination is approved in a prescribed
manner. For purposes of Section 203, a “business combination’’ includes a merger, asset sale or other transaction resulting in a financial benefit to the
interested stockholder, and an “interested stockholder’’ is a stockholder who, together with affiliates and associates, owns, or within three years prior, did
own, 15% or more of the voting stock.
Transfer Agent and Registrar
The transfer agent and registrar for our common stock is Philadelphia Stock Transfer, 2320 Haverford Road, Suite 230, Ardmore, PA 19003.
AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Exhibit 10.11
This Amended and Restated Employment Agreement (this “Agreement”) is made and entered into as of September 24, 2020, to be effective as of
September 15, 2020 (the “Effective Date”), by and between TFF Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Christopher Cano,
an individual (“Employee”).
RECITALS
WHEREAS, Employee has been serving as the Director of Business Development to the Company pursuant to that certain employment agreement
(“Original Employment Agreement”) dated December 18, 2019 between the Company and Employee.
WHEREAS, the Company now desires to hire Employee as its Chief Operating Officer and Vice President of Business Development and
Employee desires to become so employed by the Company.
WHEREAS, Employee and Company desire to amend and restate the Original Employment Agreement on the terms and conditions set forth
herein.
NOW, THEREFORE, in consideration of the promises and the mutual covenants contained herein, and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:
1. EMPLOYMENT TERMS AND DUTIES
AGREEMENT
1.1. Employment. The Company hereby employs Employee, and Employee hereby accepts employment by the Company, effective as of
the Effective Date, upon the terms and conditions set forth in this Agreement.
1.2. Duties and Reporting. Commencing as of the Effective Date, Employee shall serve as Chief Operating Officer and Vice President of
Business Development of the Company, reporting to the Chief Executive Officer. Employee shall perform all reasonable duties and have such authority as
assigned by the Chief Executive Officer.
1.2.1. Full Working Time. Employee shall devote his full working time and efforts to the performance of his duties and the
furtherance of the interests of the Company and shall not engage in any other business activity or serve in any industry, trade, professional, governmental or
academic position during the term of this Agreement, except as may be expressly approved in advance by the Chief Executive Officer in writing, provided
that Employee may (i) engage in activities that involve a de minimis amount of time or that are conducted on non-business time, in each case, without the
prior written approval of the Chief Executive Officer, (ii) make and manage personal investments of his choice without the prior written approval of the
Chief Executive Officer, and (iii) serve on the board of directors of one (1) for profit enterprise with the prior written approval of the Chief Executive
Officer, which approval shall not be unreasonably withheld, so long as such activities listed in clauses (i), (ii), and (iii), either separately or collectively, do
not materially interfere with Employee’s duties and responsibilities hereunder and are not inconsistent with the terms of any conflict of interest, securities
trading or similar material written policies of the Company applicable to Employee.
business conduct of the Company applicable to Employee’s position, as in effect from time to time.
1.2.2. Compliance With Policies. Employee shall comply with all policies, practices and procedures, and all codes of ethics or
1.2.3. Duty of Loyalty. Employee acknowledges that Employee owes a duty of care and loyalty to the Company, as well as a duty to
perform Employee’s duties in a manner that is in the best interests of the Company. Employee owes such duties to the Company in addition to duties
imposed upon Employee under applicable law.
1.3. Term. Subject to earlier termination as set forth herein, Employee’s employment hereunder shall be for a term of three (3) years,
commencing on the December 18, 2019 (“Commencement Date”). Beginning on the third (3rd) anniversary of the Commencement Date, and on each
subsequent anniversary of the Commencement Date, the term shall automatically, without further action by Employee or the Company, be extended for one
(1) year; provided, however, that either Employee or the Company may, by notice to the other given not less than ninety (90) days prior to the scheduled
expiration of the term, cause the term to cease to extend automatically. The term of this Agreement is hereafter referred to as the “Employment Term.”
1.4. Compensation and Benefits.
1.4.1. Base Salary. In consideration of the services rendered to the Company hereunder by Employee and Employee’s covenants
hereunder, the Company shall, effective as of the Effective Date and during the remaining Employment Term, pay Employee a base salary (the “Base
Salary”) of Twenty-Seven Thousand Eighty-Three Dollars and 33 cents ($27,083.33) per month, less statutory deductions and withholdings, payable in
accordance with the Company’s regular payroll practices.
1.4.2. Commission Compensation. During the Employment Term, the Company shall pay Employee a sales commission (“Sales
Commission”) based on the Net Proceeds (as defined below) actually received by the Company, up to a maximum of $1,000,000 of Sales Commissions per
calendar year, from sublicensees of the patent rights to the Company’s thin film freezing platform during the term of this Agreement. The Sales
Commission rate shall be one percent (1%) of Net Proceeds, except for any Net Proceeds with respect to which the Company is obligated to pay any third-
party a commission, finder’s fee or the like, in which case the Sales Commission rate shall be one-half of one percent (.5%) of Net Proceeds. The term “Net
Proceeds” means cash payments to the Company from sublicensees in the form of sublicensing fees, milestone payments and running royalty payments.
2
1.4.3. Annual Bonus. For each full fiscal year completed during the Employment Term commencing with the fiscal year ending
December 31, 2020, Executive shall be eligible to earn a discretionary annual bonus (the “Annual Bonus”). The target for the Annual Bonus awarded to
Executive will be twenty percent (20%) of the Base Salary in effect for the applicable year, and if Executive’s salary varies during a fiscal year, the
applicable Base Salary shall be the highest Base Salary during that year. The Annual Bonus shall be based upon Executive’s individual performance and the
performance of the Company, with reference to performance goals to be provided at the beginning of each fiscal year by the Company’s Chief Executive
Officer or the Board, as the case may be. In order to earn the Annual Bonus under this Section for any fiscal year, Executive must be employed by the
Company, and not have provided notice of resignation, as of the date payment of the Annual Bonus is made. Any Annual Bonus due to Executive
hereunder will be payable at the time bonuses, if any, are paid to other executives, but in all events not later than the March 15th following the end of the
fiscal year for which any such Annual Bonus is awarded.
1.4.4. Employee Benefits. During the Employment Term, Employee will be entitled to participate in the employee benefit plans
currently and hereafter maintained by the Company of general applicability to other senior executives of the Company, including, without limitation, the
Company's group medical, dental, vision, disability, life insurance and flexible-spending account plans. The Company reserves the right to cancel or change
the benefit plans and programs it offers to its employees at any time.
duration of specific vacations mutually and reasonably agreed to by Employee and the Company.
1.4.5. Vacation. Employee shall be entitled to paid vacation in accordance with the Company’s vacation policy, with the timing and
1.4.6. Business Expenses. During the Employment Term, the Company will reimburse Employee for reasonable travel, entertainment
or other expenses incurred by Employee in the furtherance of or in connection with the performance of Employee's duties hereunder, in accordance with the
Company's expense reimbursement policy as in effect from time to time.
1.5. Stock Options. Employee will be eligible to participate in and receive stock option or equity award grants under the Company’s
equity incentive plans from time to time in the discretion of the Board of Directors (“Board”) of the Company, and in accordance with the terms and
conditions of such plans.
3
1.6. Termination. Employee’s employment and this Agreement (except as otherwise provided hereunder) shall terminate upon the
occurrence of any of the following, at the time set forth therefor (the “Termination Date”):
1.6.1. Death or Disability. Immediately upon the death of Employee or a determination by the Company that Employee has ceased to
be able to perform the essential functions of his duties, with or without reasonable accommodation, for a period of not less than one hundred and twenty
(120) days in the aggregate within a one-year period, due to a mental or physical illness or incapacity (“Disability”) (termination pursuant to this Section
1.6.1 being referred to herein as termination for “Death or Disability”); or
1.6.2. Voluntary Termination. Ninety (90) days following Employee’s written notice to the Company of termination of employment;
provided, however, that the Company may waive all or a portion of the ninety (90) days’ notice and accelerate the effective date of such termination (and
the Termination Date) (termination pursuant to this Section 1.6.2 being referred to herein as “Voluntary Termination”); or
1.6.3. Termination For Cause. Immediately following notice of termination for “Cause” (as defined below), specifying such Cause,
given by the Company (termination pursuant to this Section 1.6.3 being referred to herein as “Termination for Cause”). As used herein, “Cause” means (i)
termination based on Employee’s conviction or plea of “guilty” or “no contest” to any crime constituting a felony in the jurisdiction in which committed,
any crime involving moral turpitude (whether or not a felony), or any other violation of criminal law involving dishonesty or willful misconduct that
injures the Company’s interests or reputation (whether or not a felony); (ii) Employee’s substance abuse that in any manner interferes with the performance
of his duties; (iii) Employee’s failure or refusal to perform his duties at all or in an acceptable manner in the reasonable judgment of the Board or to follow
the lawful and proper directives of the Board that are within the scope of Employee’s duties; (iv) Employee’s material breach of this Agreement which, if
curable, is not cured within fifteen (15) days after receipt of written notice of such material breach; (v) Employee’s material breach of the PIIA;
(vi) misconduct by Employee that has or could discredit or damage the Company; (vii) Employee’s indictment for a felony violation of the federal
securities laws; or (viii) Employee’s chronic absence from work for reasons other than illness.
1.6.4. Termination Without Cause. Notwithstanding any other provisions contained herein, including, but not limited to Section 1.3
above, the Company may terminate Employee’s employment thirty (30) days following notice of termination without Cause given by the Company;
provided, however, that during any such thirty (30) day notice period, the Company may suspend, with no reduction in pay or benefits, Employee from his
duties as set forth herein (including, without limitation, Employee’s position as a representative and agent of the Company) (termination pursuant to this
Section 1.6.4 being referred to herein as “Termination Without Cause”).
4
1.6.5. Resignation for “Good Reason”. Notwithstanding any other provisions contained herein, Employee may resign his position for
good reason if any one of the following occurs, without Employee’s consent: (i) a reduction in Employee’s Base Salary greater than 10% and material or
significant reduction in benefits from those in effect at the time the change is indicated, other than reductions in salary and/or benefits that are applied to all
executive officers of the Company, or (ii) relocation of Employee’s office farther than 50 miles from Employee’s office location at the commencement of
this Agreement; provided, however, that with respect to either of the foregoing clauses (i) – (ii), Employee has provided written notice to the Company of
the existence of the condition or conditions constituting Good Reason within ninety (90) days of the condition or conditions first occurring, and the
Company has failed to cure the condition or conditions specified in such notice despite having been given at least thirty (30) days after receipt of such
notice to cure such condition or conditions (termination pursuant to this Section 1.6.5 being referred herein to “Resignation for Good Reason”).
remedy to which the Company may be entitled at law, in equity, or under this Agreement.
1.6.6. Other Remedies. Termination pursuant to this section above shall be in addition to and without prejudice to any other right or
1.7. Severance and Termination.
1.7.1. Voluntary Termination, Termination for Cause, Termination for Death or Disability. In the case of a termination of Employee’s
employment hereunder for Death or Disability in accordance with Section 1.6.1 above, or Employee’s Voluntary Termination in accordance with Section
1.6.2 above, or a termination of Employee’s employment hereunder for Cause in accordance with Section 1.6.3 above, (i) Employee shall not be entitled to
receive payment of, and the Company shall have no obligation to pay, any severance or similar compensation attributable to such termination, other than
base salary earned but unpaid and any unreimbursed expenses pursuant to Section 1.4.5 hereof incurred by Employee as of the termination date, and (ii) the
Company’s obligations under this Agreement shall immediately cease.
1.7.2. Termination Without Cause and Resignation for Good Reason. Subject to the provisions set forth in this Agreement, in the
case of a Termination Without Cause of Employee’s employment hereunder in accordance with Section 1.6.4 or Resignation for Good Reason in
accordance with Section 1.6.5 above, the Company shall pay Employee twelve (12) months’ base salary then in effect (hereinafter the “Severance
Payments”), less statutory deductions and withholdings, payable in the form of salary continuation and pursuant to the Company’s normal payroll cycle.
The Company’s obligation to make Severance Payments is conditioned upon Employee timely signing and returning to the Company (and not revoking) a
release agreement in a form satisfactory to the Company (which shall include, but not be limited to, a full release of claims of Employee’s claims against
the Company) and on Employee’s continued compliance with Employee’s obligations to the Company that survive termination of his employment in this
Agreement in and in the PIIA.
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1.8. Timing of Payments and Section 409A.
1.8.1. Notwithstanding anything to the contrary in this Agreement, if at the time of Employee’s termination of employment,
Employee is a “specified employee,” as defined below, any and all amounts payable under this Section 1 on account of such separation from service, to the
extent required in order to avoid accelerated taxation and/or tax penalties under Section 409A of the Code (“Section 409A”) that constitute deferred
compensation and would (but for this provision) be payable within six (6) months following the date of termination, shall instead be paid on the next
business day following the expiration of such six (6) month period or, if earlier, upon Employee’s death.
1.8.2. For purposes of this Agreement, all references to “termination of employment” and correlative phrases shall be construed to
require a “separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after giving effect to the presumptions contained
therein), and the term “specified employee” means an individual determined by the Company to be a specified employee under Treasury Regulation
Section 1.409A-1(i).
payments under this Agreement is to be treated as a right to a series of separate payments.
1.8.3. Each payment made under this Agreement shall be treated as a separate payment and the right to a series of installment
1.8.4. Any reimbursement for expenses or provision of in-kind benefits that would constitute nonqualified deferred compensation
subject to Section 409A shall be subject to the following additional rules: (i) the amount of expenses eligible for reimbursement, or the in-kind benefits to
be provided, during any taxable year shall not affect the amount of expenses eligible for reimbursement, or in-kind benefits to be provided, in any other
taxable year; (ii) reimbursement of the expense shall be made, if at all, promptly, but not later than the end of the calendar year following the calendar year
in which the expense was incurred; and (iii) the right to reimbursement or to in-kind benefits shall not be subject to liquidation or exchange for any other
benefit.
1.8.5. The parties hereto agree that their intent is that payments and benefits under this Agreement comply with or be exempt from
Section 409A to the extent applicable. This Agreement shall be interpreted to comply with or be exempt from Section 409A, and all provisions of this
Agreement shall be construed in a manner consistent with the requirements for avoiding taxes or penalties under Section 409A.
2. PROTECTION OF COMPANY’S PROPRIETARY INFORMATION AND INVENTIONS
This Agreement, and Employee’s employment hereunder, is subject to the Proprietary Information and Inventions Agreement (“PIIA”)
dated November 30, 2018 between the Company and Employee, which is incorporated herein by this reference. The PIIA survives the termination of the
Original Employment Agreement and shall also survive the termination of this Agreement, the Employment Term and/or Employee’s employment with the
Company.
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3. REPRESENTATIONS AND WARRANTIES BY EMPLOYEE
3.4. No Contrary Agreements or Claims. Employee represents and warrants to the Company that (i) unless otherwise provided in writing
prior to signing this Agreement, Employee is not bound by or subject to any contractual or other obligation that would be violated by his execution or
performance of this Agreement, including, but not limited to, any non-competition or non-solicitation agreement presently in effect, and (ii) Employee is
not subject to any pending or, to Employee’s knowledge, threatened claim, action, judgment, order, or investigation that could adversely affect his ability to
perform his obligations under this Agreement or the business reputation of the Company. Employee has not entered into, and agrees that he will not enter
into, any agreement either written or oral in conflict herewith.
3.5. Cooperation. Employee agrees to cooperate with the Company in connection with matters arising out of Employee’s service to the
Company and assist the Company and its attorneys in the prosecution or defense of any litigation or similar proceedings to which the Company is a party,
or matters concerning which litigation or similar proceedings subsequently arise, relating to any matter falling within Employee’s knowledge or former area
of responsibility. Employee agrees to provide reasonable assistance and completely truthful testimony in such matters, including, without limitation,
consulting on matters relating to Employee’s service to the Company, facilitating and assisting in the preparation of any underlying defense, responding to
discovery requests, preparing for and attending deposition(s), as well as appearing in court to provide truthful testimony. The Company shall reimburse
Employee any reasonable out-of-pocket expenses necessary for Employee to comply with the obligations under this Section 3.5 (including, without
limitation, reasonable travel expenses, lodging and meals) in accordance with the Company’s expense reimbursement policies and, if such policies only
permit reimbursement of expenses for active employees, to the same extent Employee would have been reimbursed if he were an active employee at the
time such expenses were incurred.
3.6. Non-Disparagement. Employee shall not, at any time during or following his employment, make statements or representations, or
otherwise communicate, directly or, if undertaken at the direction of Employee, indirectly, in writing, orally, or otherwise, or take any action which, directly
or indirectly, disparages any member of the Company, or their respective officers, equityholders, general partners, limited partners, members, managers,
directors, employees, or advisors, or the businesses or reputations of any of the foregoing.
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4. MISCELLANEOUS
4.4. Notices. Any and all notices, requests, demands and other communications provided for by this Agreement shall be in writing and
shall be deemed given (a) upon actual receipt by the party to which such notice shall be directed if delivered by hand or electronic mail; (b) three (3)
business days after the date of deposit in the U.S. mail, postage prepaid, registered or certified; or (c) on the next business day, if sent by prepaid reputable
national overnight courier service, in each case addressed to as provided below, or to such other address as either party hereto may specify by notice to the
other in the manner set forth above:
If to the Company, to:
TFF Pharmaceuticals, Inc.
2600 Via Fortuna, Suite 360
Austin, Texas 78746
Email: kcoleman@tffpharma.com
If to Employee, to:
Christopher Cano
24 Woodfield Lane
Lawrenceville, New Jersey 08648
Email: ccano@tffpharma.com
4.5. Authorization to be Employed. This Agreement, and Employee’s employment hereunder, is subject to Employee providing the
Company with legally required proof of Employee’s authorization to be employed in the United States of America within three days of the commencement
of Employee’s employment.
4.6. Entire Agreement. This Agreement, the PIIA, together with any equity-based written agreements between Employee and the
Company, supersede all prior discussions and agreements among the parties with respect to the subject matter hereof and contain the sole and entire
agreement between the parties hereto with respect thereto. The Original Employment Agreement is hereby terminated.
4.7. Survival. The respective rights and obligations of the parties in this Agreement and the PIIA that are designed to last beyond the
employment relationship hereto shall survive the termination of this Agreement, the Employment Term and/or Employee’s employment with the Company.
4.8. Waiver. Any term or condition of this Agreement may be waived at any time by the party that is entitled to the benefit thereof, but no
such waiver shall be effective unless set forth in a written instrument duly executed by or on behalf of the party waiving such term or condition. No waiver
by any party hereto of any term or condition of this Agreement, in any one or more instances, shall be deemed to be or construed as a waiver of the same or
any other term or condition of this Agreement on any future occasion. All remedies, either under this Agreement or by law or otherwise afforded, will be
cumulative and not alternative.
4.9. Amendment. This Agreement may be amended, supplemented, or modified only by a written instrument duly executed by or on
behalf of each party hereto.
4.10. Recovery of Attorney’s Fees. In the event of any litigation arising from or relating to this Agreement, the prevailing party in such
litigation proceedings shall be entitled to recover, from the non-prevailing party, the prevailing party’s reasonable costs and attorney’s fees, in addition to all
other legal or equitable remedies to which it may otherwise be entitled.
8
4.11. No Assignment; Binding Effect. This Agreement shall inure to the benefit of any successors or assigns of the Company. Employee
shall not be entitled to assign his obligations under this Agreement. The Company shall have the right at any time to assign this Agreement to its successors
and assigns; provided, however, that the assignee or transferee is the successor to all or substantially all of the business assets of the Company and such
assignee or transferee expressly assumes all of the obligations, duties, and liabilities of the company set forth in this Agreement.
provisions hereof.
4.12. Headings. The headings used in this Agreement have been inserted for convenience of reference only and do not define or limit the
4.13. Severability. The Company and Employee intend all provisions of this Agreement to be enforced to the fullest extent permitted by
law. Accordingly, if a court of competent jurisdiction determines that the scope and/or operation of any provision of this Agreement is too broad to be
enforced as written, the Company and Employee intend that the court should reform such provision to such narrower scope and/or operation as it
determines to be enforceable. If, however, any provision of this Agreement is held to be illegal, invalid, or unenforceable under present or future law, and
not subject to reformation, then (i) such provision shall be fully severable, (ii) this Agreement shall be construed and enforced as if such provision was
never a part of this Agreement, and (iii) the remaining provisions of this Agreement shall remain in full force and effect and shall not be affected by illegal,
invalid, or unenforceable provisions or by their severance.
4.14. Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
LAWS OF THE STATE OF TEXAS APPLICABLE TO CONTRACTS EXECUTED AND PERFORMED IN SUCH STATE WITHOUT GIVING
EFFECT TO CONFLICTS OF LAWS PRINCIPLES.
4.15. Jurisdiction and Venue. With respect to any suit, action, or other proceeding arising from (or relating to) this Agreement, the
Company and Employee hereby irrevocably agree to the exclusive personal jurisdiction and venue of the United States District Court for the Western
District of Texas, Austin Division (and any Texas State Court within Travis County, Texas).
original, but all of which together will constitute one and the same instrument.
4.16. Counterparts. This Agreement may be executed in any number of counterparts and by facsimile, each of which will be deemed an
4.17. Construction. The parties acknowledge that this Agreement is the result of arm’s length negotiations between sophisticated parties
each afforded representation by legal counsel. Each and every provision of this Agreement shall be construed as though both parties participated equally in
the drafting of same, and any rule of construction that a document shall be construed against the drafting party shall not be applicable to this Agreement.
[SIGNATURE PAGE TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT FOLLOWS]
9
IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed on the date first written above.
“Company”
TFF Pharmaceuticals, Inc.,
a Delaware corporation
By:
/s/ Glenn Mattes
Glenn Mattes,
Chief Executive Officer
“Employee”
/s/ Christopher Cano
Christopher Cano
INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM’S CONSENT
We consent to the incorporation by reference in the Registration Statement of TFF Pharmaceuticals, Inc. on Form S-3 (File No. 333-249870) and Form S-8
(File No. 333-249364) of our report dated March 10, 2021, with respect to our audits of the consolidated financial statements of TFF Pharmaceuticals, Inc.
as of December 31, 2020 and 2019 and for each of the two years in the period ended December 31, 2020, which report is included in this Annual Report on
Form 10-K of TFF Pharmaceuticals, Inc. for the year ended December 31, 2020.
Exhibit 23.1
/s/ Marcum LLP
Marcum LLP
New York, NY
March 10, 2021
EXHIBIT 31.1
I, Glenn Mattes, certify that:
(1) I have reviewed this annual report on Form 10-K of TFF Pharmaceuticals, Inc.;
CERTIFICATIONS
(2) Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;
(3) Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
(4) The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the company and have:
(a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;
(b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;
(c) evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the period covered by this report based on such evaluation; and
(d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent
quarter (the registrant’s fourth quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the
registrant’s internal control over financial reporting; and
(5) The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
registrant’s auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent functions):
(a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control
over financial reporting.
Date: March 10, 2021
TFF PHARMACEUTICALS, INC.
By:
/s/ Glenn Mattes
Glenn Mattes, Chief Executive Officer
EXHIBIT 31.2
I, Kirk Coleman, certify that:
(1) I have reviewed this annual report on Form 10-K of TFF Pharmaceuticals, Inc.;
CERTIFICATIONS
(2) Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;
(3) Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
(4) The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the company and have:
(a) designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;
(b) designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;
(c) evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the period covered by this report based on such evaluation; and
(d) disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent
quarter (the registrant’s fourth quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the
registrant’s internal control over financial reporting; and
(5) The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the
registrant’s auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent functions):
(a) all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
(b) any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control
over financial reporting.
Date: March 10, 2021
TFF PHARMACEUTICALS, INC.
By:
/s/ Kirk Coleman
Kirk Coleman, Chief Financial Officer
(Principal Financial Officer)
CERTIFICATION PURSUANT TO
18 U.S.C. ss.1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
EXHIBIT 32.1
In connection with the Annual Report of TFF Pharmaceuticals, Inc. (the “Company”) on Form 10-K for the period ended December 31, 2020 as filed with
the Securities and Exchange Commission on the date hereof (the “Report”), I, Glenn Mattes, the Chief Executive Officer, and Kirk Coleman, the Chief
Financial Officer, of the Company, respectively, certify, pursuant to 18 U.S.C. §1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002, that to my knowledge:
1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
By:
/s/ Glenn Mattes
Glenn Mattes
Title: Chief Executive Officer
(Principal Executive Officer)
By:
/s/ Kirk Coleman
Kirk Coleman
Title: Chief Financial Officer
(Principal Financial and Accounting Officer)
Dated: March 10, 2021
Dated: March 10, 2021
This certification is made solely for the purposes of 18 U.S.C. Section 1350, subject to the knowledge standard contained therein, and not for any other
purpose.