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Karuna TherapeuticsAorTech International plc FY 2009 Annual General Meeting Expansion, Growth and Expansion, Growth and Achievement Marriott Chancery Court London Sept 2009 License growth and activity • Major developments – New and expanded fields: • License and manufacturing supply agreement for • License and manufacturing supply agreement for circulatory support pumps • Royalty bearing Mitral Heart Valve repair licensee approaching human trial phase • Doubling of pacemaker lead polymer volumes • First (royalty bearing) vascular stent license – expected human use 2010 AorTech 2009 Annual Meeting Progress on many fronts License growth and activity • Major developments – New and expanded fields: • Market introduction of new royalty bearing non- vascular stent for prostate treatment vascular stent for prostate treatment • 510k submitted for first urology application • Royalty bearing AV fistula license signed, development encouraging • First header license and component supply agreement, several more in evaluation stage • High value license for use of AorTech polymer heart valve in circulatory support pump AorTech 2009 Annual Meeting Progress on many fronts License Maturation • Expansion of pacemaker lead license to include new polymers • Cardiac device co-development project expanded into second application into second application • Patient numbers (including all applications) approaching 2,000,000 – Zero reported failures AorTech 2009 Annual Meeting Progress on many fronts Component Business • Expansion of reaction injection molding (RIM) evaluations for several Orthopedic applications • RIM process evolution results in new IP filings • High gross margin Bi-Vad component manufacturing projected to reach recurring manufacturing projected to reach recurring revenues in excess of $250k per annum over 24 months • High gross margin Polymer HV manufacturing for VAD use commenced in September 2009 AorTech 2009 Annual Meeting Progress on many fronts Component Business Elast-Eon RIM Header AorTech 2009 Annual Meeting Progress on many fronts Component Business Polymer Heart Valve in Cardiac Assist Pump AorTech 2009 Annual Meeting Progress on many fronts Summary • Revenues of several types and from multiple customers and continue to build • Business operations are sound, consistent and highly leveragable • New polymer materials in pipeline • Cash position remains strong AorTech 2009 Annual Meeting Progress on many fronts
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