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Ardelyx, Inc.

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FY2020 Annual Report · Ardelyx, Inc.
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-K

(Mark One)
☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2020

OR

FOR THE TRANSITION PERIOD FROM                     TO                     

COMMISSION FILE NUMBER 001-36485

ARDELYX, INC.

(EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

DELAWARE
(STATE OR OTHER JURISDICTION OF
INCORPORATION OR ORGANIZATION)

26-1303944
(I.R.S. EMPLOYER
IDENTIFICATION NO.)

34175 ARDENWOOD BLVD., FREMONT, CALIFORNIA 94555
400 FIFTH AVE., SUITE 210, WALTHAM, MASSACHUSETTS 02451
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES, INCLUDING ZIP CODE)

(510) 745-1700
(REGISTRANT’S TELEPHONE NUMBER, INCLUDING AREA CODE)

Securities registered pursuant to Section 12(b) of the Act:

Title of Each Class
Common Stock, par value $0.0001 per share

Trading Symbol(s)
ARDX

Name of Each Exchange on Which Registered
The Nasdaq Global Market

Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark if the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐  No ⌧

Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes ☐  No ⌧
Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding
12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.  Yes ⌧  No
☐
Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T
(§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files). Yes ⌧ No ☐
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
company. See the definition of “large accelerated filer”, “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer  ☐
Non-accelerated filer  ⌧  

Accelerated filer ☐
Small reporting company ☒
Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial
reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ⌧
The aggregate market value of the Registrant’s common stock held by non-affiliates of the Registrant as of the last business day of the Registrant’s most recently completed
second fiscal quarter, June 30, 2020, based on the last reported sales price of the Registrant’s common stock of $6.92 per share was $611,732,242.
The number of shares of Registrant’s Common Stock outstanding as of March 3, 2021, was 98,680,264.

DOCUMENTS INCORPORATED BY REFERENCE:
Portions of the Registrant’s Definitive Proxy Statement for its 2021 Annual Meeting of Stockholders, which will be filed with the Commission within 120 days of December 31,
2020, the close of the Registrant’s 2020 fiscal year, are incorporated by reference into Part III of this Report.

    
    
 
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ARDELYX, INC.
FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 2020
TABLE OF CONTENTS

Business

Item 1.
Item 1A. Risk Factors
Item 1B. Unresolved Staff Comments
Item 2.
Item 3.
Item 4. Mine Safety Disclosures

Properties
Legal Proceedings

PART I

PART II

Item 5. Market  for  Registrant’s  Common  Equity,  Related  Stockholder  Matters  and  Issuer  Purchases  of  Equity

Securities
Selected Financial Data

Item 6.
Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations
Item 7A. Quantitative and Qualitative Disclosures About Market Risk
Item 8.
Item 9.
Item 9A. Controls and Procedures
Item 9B. Other Information

Financial Statements and Supplementary Data
Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

PART III

Item 10. Directors, Executive Officers and Corporate Governance
Item 11.
Item 12.
Item 13. Certain Relationships and Related Transactions, and Director Independence
Item 14.

Executive Compensation
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

Principal Accounting Fees and Services

Item 15.
Item 16.

Exhibits, Financial Statement Schedules
Form 10-K Summary

PART IV

Signatures

Page

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NOTE REGARDING FORWARD-LOOKING STATEMENTS

Unless the context requires otherwise, in this Annual Report on Form 10-K the terms “Ardelyx”, “we,” “us,” “our”

and “the Company” refer to Ardelyx, Inc.

This  Annual  Report  on  Form  10-K  contains  forward-looking  statements  that  involve  risks  and  uncertainties.  Any
statements contained herein that are not statements of historical facts may be deemed to be forward-looking statements. In
some cases, you can identify forward-looking statements by terminology such as “aim,” “anticipate,” “assume,” “believe,”
“continue,”  “could,”  “due,”  “estimate,”  “expect,”  “goal,”  “intend,”  “may,”  “objective,”  “plan,”  “predict,”  “potential,”
“positioned,” “seek,” “should,” “target,” “will,” “would,” and other similar expressions that are predictions of or indicate
future  events  and  future  trends,  or  the  negative  of  these  terms  or  other  comparable  terminology.  These  forward-looking
statements include, but are not limited to, statements about:

● our  expectations  regarding  our  plans  for  and  our  participation  in  the  commercialization  of  tenapanor  for  the
control of serum phosphorus in chronic kidney disease, or CKD, patients on dialysis, including our expectations
regarding  our  plans  to  build  our  own  sales  and  marketing  organization  to  market  and  sell  tenapanor  for  such
indication;

● our  expectations  regarding  the  potential  market  size  and  the  size  of  the  patient  populations  for  our  product

candidates;

● our plans with respect RDX013 and to our pre-clinical programs;

● our ability to identify and validate targets and novel drug candidates using our proprietary drug discovery and
design platform including the Ardelyx Primary Enterocyte and Colonocyte Culture System, or APECCS, or any
other proprietary drug discovery and design platform we develop for the identification, screening, testing, design
and development of new product candidates for the treatment of renal diseases;

● the  implementation  of  our  business  model  and  strategic  plans  for  our  business,  product  candidates  and

technology;

● estimates of our expenses, future revenue, capital requirements, our needs for additional financing and our ability

to obtain additional capital;

● our financial performance; and

● developments and projections relating to our competitors and our industry.

Factors that could cause actual results or conditions to differ from those anticipated by these and other forward-looking
statements include those more fully described in the “ITEM 1A. RISK FACTORS” section and elsewhere in this Annual
Report  on  Form  10-K.  Except  as  required  by  law,  we  assume  no  obligation  to  update  any  forward-looking  statement
publicly,  or  to  revise  any  forward-looking  statement  to  reflect  events  or  developments  occurring  after  the  date  of  this
Annual Report on Form 10-K, even if new information becomes available in the future. Thus, you should not assume that
our  silence  over  time  means  that  actual  events  are  bearing  out  as  expressed  or  implied  in  any  such  forward-looking
statement.

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ITEM 1. BUSINESS

Company Overview

We are a specialized biopharmaceutical company focused on developing first-in-class medicines to improve treatment
for people with kidney and cardiorenal diseases. This includes patients with chronic kidney disease (”CKD”) on dialysis
suffering  from  elevated  serum  phosphorus,  or  hyperphosphatemia;  and  CKD  patients  and/or  heart  failure  patients  with
elevated serum potassium, or hyperkalemia. Our lead product candidate, tenapanor, is a first-in-class medicine for which
we submitted a New Drug Application (“NDA”) to the U.S. Food and Drug Administration (“FDA”) in June 2020 for the
control of serum phosphorus in adult patients with CKD on dialysis. In September 2020 the FDA accepted the filing of our
NDA and set a Prescription Drug User Fee Act (“PDUFA”) date of April 29, 2021. Tenapanor has a unique mechanism of
action and acts locally in the gut to inhibit the sodium hydrogen exchanger 3, or NHE3. This results in the tightening of the
epithelial cell junctions, thereby significantly reducing paracellular uptake of phosphate, the primary pathway of phosphate
absorption.

OUR PRODUCT PIPELINE

Tenapanor: A New Approach for The Control of Serum Phosphorus in CKD Patients on Dialysis

Our portfolio is led by the development of tenapanor, a first-in-class medicine for the control of serum phosphorus in
adult patients with CKD on dialysis. Tenapanor for the control of serum phosphorus has a unique mechanism of action and
acts locally in the gut to inhibit the sodium hydrogen exchanger 3 (“NHE3”). This results in the tightening of the epithelial
cell  junctions,  thereby  significantly  reducing  paracellular  uptake  of  phosphate,  the  primary  pathway  of  phosphate
absorption.  On  September  15,  2020  we  announced  that  the  FDA  accepted  the  filing  of  our  NDA  for  tenapanor  for  the
control  of  serum  phosphorus  in  adult  patients  with  CKD  on  dialysis.  The  acceptance  of  our  NDA  represents  the  next
critical step toward bringing to market a completely new approach to the management of hyperphosphatemia. The FDA has
set a PDUFA date of April 29, 2021. We continue to advance commercial preparations for the launch of tenapanor for this
indication. The NDA is supported by three successful Phase 3 trials involving over 1,000 patients that evaluated the use of
tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis,  with  two  trials  evaluating  tenapanor  as
monotherapy and one trial evaluating tenapanor as part of a dual mechanism approach with phosphate binders.

We  have  established  agreements  with  Kyowa  Kirin  Co.,  Ltd.  (“KKC”)  in  Japan,  Shanghai  Fosun  Pharmaceutical
Industrial Development Co. Ltd. (“Fosun Pharma”) in China and Knight Therapeutics, Inc. (“Knight”) in Canada for the
development and commercialization of tenapanor for certain indications in their respective territories.

In December 2019, we reported statistically significant topline efficacy results from our second monotherapy Phase 3
clinical trial, the PHREEDOM trial, which evaluated tenapanor for the control of serum phosphorus in CKD patients on
dialysis. The PHREEDOM trial followed a successful monotherapy Phase 3 clinical trial completed in 2017, the BLOCK
trial,  which  achieved  statistical  significance  for  the  primary  endpoint.  The  only  adverse  event  reported  in  these  Phase  3
trials in greater than 5% of patients was diarrhea, with an incidence rate of 52% in the PHREEDOM trial and 39% in the
BLOCK trial, with most incidences in each trial being mild to moderate in nature. PHREEDOM is a one-year study with a
26-week  open-label  treatment  period  and  a  12-week  double-blind,  placebo-controlled  randomized  withdrawal  period
followed by a 14-week open-label safety extension period. An active safety control group, for safety analysis only, received
sevelamer,  open-label,  for  the  entire  52-week  study  period.  Patients  completing  the  PHREEDOM  trial  from  both  the
tenapanor  arm  and  the  sevelamer  active  safety  control  arm  had  the  option  to  participate  in  NORMALIZE,  an  ongoing
open-label 18-month extension study.

In June 2020, we announced positive results from a planned analysis from our ongoing NORMALIZE extension study
evaluating tenapanor, as monotherapy or in combination with sevelamer, to achieve serum phosphorus levels in the normal
range (2.5 – 4.5 mg/dL) in patients with CKD on dialysis. The NORMALIZE extension study allowed patients from our
PHREEDOM study to continue therapy with tenapanor and enabled those patients in the PHREEDOM safety control arm
receiving sevelamer carbonate to transition to tenapanor. The data from the planned interim analysis demonstrated that the
foundational use of tenapanor as monotherapy or in combination with sevelamer carbonate produces a significant

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phosphorus-lowering effect with a mean serum phosphorous reduction of 2.33 mg/dL, from a mean baseline phosphorus of
7.27 mg/dL at the beginning of the PHREEDOM trial to a mean of 4.94 mg/dL at the time of this analysis.

In  September  2019,  we  reported  positive  results  from  the  AMPLIFY  trial,  a  Phase  3  study  evaluating  tenapanor  in
patients with CKD on dialysis who had uncontrolled hyperphosphatemia despite phosphate binder treatment. In this trial,
approximately  twice  the  number  of  patients  achieved  the  serum  phosphorus  treatment  goal  of  less  than  5.5  mg/dL  with
tenapanor  and  phosphate  binders  versus  phosphate  binders  alone.  The  only  adverse  event  with  a  placebo-adjusted  rate
greater than 3% was diarrhea, with an incidence rate of 43%, with most being mild to moderate in nature.

Tenapanor, if approved, would be the first therapy for phosphate management that blocks phosphorus absorption at the
primary pathway of uptake. It is not a phosphate binder. Tenapanor is a novel, potent, small molecule, that has been shown
in  our  phase  3  studies  to  treat  hyperphosphatemia  as  monotherapy  and  as  part  of  a  dual  mechanism  approach.
Additionally,  we  believe  tenapanor  could  greatly  improve  patient  adherence  and  compliance  with  one  single  pill  dosed
twice daily in contrast to current therapies where typically multiple pills are taken before every meal.

RDX013 Program: Small Molecule for Treating Hyperkalemia

We  are  also  advancing  a  small  molecule  potassium  secretagogue  program,  RDX013,  for  the  potential  treatment  of
hyperkalemia. Hyperkalemia is a common problem in patients with heart and kidney disease, particularly in patients taking
customary  blood  pressure  medications  known  as  renin-angiotensin-aldosterone  system  (“RAAS”)  inhibitors.  Similar  to
what  we  have  done  with  tenapanor  in  developing  a  non-binder  approach  for  the  treatment  of  elevated  serum  phosphate
levels,  RDX013  is  designed  to  target  the  underlying  biological  mechanisms  of  potassium  secretion  to  lower  elevated
potassium. While currently available therapies are all ion exchange agents, RDX013 is a first in class secretagogue that has
been shown in preclinical and Phase 1 studies to harness and amplify the body’s natural mechanism for colonic potassium
secretion. We have initiated a Phase 2 study to evaluate the safety and pharmacodynamics of RDX013 at different doses
and to assess the safety and efficacy of treatment with RDX013 at the selected optimal dose in patients with hyperkalemia.

IBSRELA® (tenapanor) for Irritable Bowel Syndrome with Constipation (IBS-C)

In addition to the development of tenapanor for hyperphosphatemia, we have developed tenapanor for the treatment of
patients with IBS-C. In September 2019, we received FDA approval of IBSRELA® (tenapanor) for the treatment of IBS-C
in adults. IBS-C is a burdensome gastrointestinal (“GI”) disorder characterized by significant abdominal pain, constipation,
straining during bowel movements, bloating and/or gas.

We  expect  to  continue  to  incur  substantial  operating  losses  for  the  foreseeable  future  as  a  result  of  costs  associated
with the following activities: our continued development of tenapanor for the control of serum phosphorus in CKD patients
on dialysis; our preparations for, and, if approved, the commercialization of tenapanor in the United States for the control
of  serum  phosphorus  in  CKD  patients  on  dialysis,  including  significantly  increased  personnel  costs  associated  with  our
commercial team; the performance of certain activities required as a result of our NDA approval of tenapanor for IBS-C;
the continued development of RDX013; and the advancement of our research programs into the preclinical stage. To date,
we have funded our operations from the sale and issuance of common stock and convertible preferred stock, funds from
our collaboration partnerships, and funds from our Loan Agreement with Solar Capital Ltd. and Western Alliance Bank.

RDX020 Program: Small molecule for Treating Metabolic Acidosis

We have an ongoing discovery program targeting the inhibition of bicarbonate exchange inhibitor for the treatment of
metabolic acidosis, a highly prevalent comorbidity in CKD patients that is strongly correlated with disease progression and
adverse outcomes. We have identified lead compounds that are potent, selective and proprietary inhibitors of bicarbonate
secretion.  

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Since commencing operations in October 2007, substantially all our efforts have been dedicated to our research and
development  (“R&D”)  activities,  including  developing  our  clinical  product  candidate  tenapanor  and  developing  our
proprietary drug discovery and design platform. We have not generated any revenues from product sales. As of December
31, 2020, we had an accumulated deficit of $554.8 million.

OUR COMMERCIAL STRATEGY

We  currently  intend  to  build  a  multi-product  company  that  commercializes  its  cardiorenal  products  in  the  United
States.  We  have  executed  ex-U.S.  collaborations  with  established  industry  leaders  to  efficiently  bring  tenapanor  for
hyperphosphatemia and IBS-C to patients in specific territories outside of the Unites States. We continue to evaluate our
strategy for the commercialization of tenapanor in other ex-U.S. territories, as well as our U.S. commercialization strategy
for  tenapanor  for  IBS-C.  We  currently  have  three  collaboration  partnerships:  with  Kyowa  Kirin  Co.,  Ltd.  (“KKC”)  for
commercialization  of  tenapanor  for  the  treatment  of  cardiorenal  diseases,  including  hyperphosphatemia,  in  Japan;  with
Shanghai  Fosun  Pharmaceutical  Industrial  Development  Co.  Ltd.  (“Fosun  Pharma”)  for  the  commercialization  of
tenapanor for the treatment of IBS-C and hyperphosphatemia in China; and with Knight Therapeutics, Inc. (“Knight”) for
commercialization of tenapanor for the treatment of IBS-C and hyperphosphatemia in Canada.

OUR PROPRIETARY DRUG DISCOVERY AND DESIGN PLATFORM

We have developed a proprietary drug discovery and design platform to enable the identification, screening, testing,
design  and  development  of  new  product  candidates.  Our  platform  integrates  two  critical  concepts:  (i)  our  proprietary
chemistry  capabilities  that  enable  us  to  design  and  optimize  gut-restricted  compounds,  and  (ii)  our  APECCs  stem  cell
platform  developed  to  emulate,  in  a  miniaturized  format,  the  function  and  structure  of  cells  of  specific  segments  of  the
intestine. In line with our overall strategy to focus on our cardiorenal pipeline, our research supports tenapanor, RDX013
and other potential cardiorenal opportunities.

OUR STRATEGIC PARTNERSHIPS

License Agreement with KKC

In November 2017, we entered into a License Agreement (the “2017 KKC Agreement”) with KKC under which we
granted  KKC  an  exclusive  license  to  develop  and  commercialize  tenapanor  in  Japan  for  the  treatment  of  cardiorenal
diseases and conditions, excluding cancer (the “KKC Field”). We retained the rights to tenapanor outside of Japan, and also
retained  the  rights  to  tenapanor  in  Japan  for  indications  other  than  those  in  the  KKC  Field.  Pursuant  to  the  2017  KKC
Agreement, KKC is responsible for all of the development and commercialization costs for tenapanor in the KKC Field in
Japan.

Under  the  2017  KKC  Agreement,  we  are  responsible  for  supplying  the  tenapanor  drug  substance  for  KKC’s  use  in
development and commercialization throughout the term of the 2017 KKC Agreement, provided that KKC may exercise an
option to manufacture the tenapanor drug substance under certain conditions.

Under the terms of the 2017 KKC Agreement, we received a $30.0 million upfront payment and are eligible to receive
up to $55.0 million in total development milestones, of which we have received $5.0 million to date. Additionally, under
the  2017  KKC  Agreement  we  are  eligible  to  receive  up  to  8.5  billion  yen  in  commercialization  milestones,  worth  up  to
$82.4 million at the exchange rate on December 31, 2020, and royalties based on aggregate annual net sales of the licensed
products at a high teens percentage, subject to certain single digit reductions under certain circumstances described in the
2017 KKC Agreement.

The  2017  KKC  Agreement  will  continue  until  all  of  KKC’s  applicable  payment  obligations  under  the  2017  KKC
Agreement have been performed or have expired, or the agreement is earlier terminated. Under the terms of the 2017 KKC
Agreement, we and KKC each have the right to terminate the agreement for material breach by the other party. In addition,
KKC may terminate the agreement for convenience; for certain safety reasons or if certain primary endpoints under an

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applicable development plan are not met despite KKC’s commercially reasonable efforts and KKC reasonably determines
that  it  cannot  obtain  regulatory  approval.  We  may  terminate  the  2017  KKC  Agreement  if  KKC  challenges  any  patents
licensed to KKC under the agreement.

Research Collaboration with KKC

In  November  2019,  we  entered  into  a  Research  Collaboration  and  Option  Agreement  “(the  2019  KKC  Research
Agreement”) which expanded our strategic partnership with KKC. In the KKC Research Agreement, we established a two-
year  research  collaboration,  under  which  we  are  executing  a  research  plan,  with  KKC  participation,  to  advance  two
research programs focused on identification and design of compounds to two undisclosed targets. KKC agreed to pay us
$10.0 million ($5.0 million per year, for a period of two years) to support the ongoing research. As of December 31, 2020,
we have received the full $10.0 million. Following the end of the research period, KKC will have the option to license any
candidates nominated by the companies for further development and commercialization in certain specified territories, with
additional commitments payable to us of up to $10.5 million in upfront payments and up to $500.0 million in development
and sales milestones.

License Agreement with Fosun

In December 2017, we entered into a license agreement (“the Fosun License Agreement”) with Fosun Pharma under
which we granted Fosun Pharma an exclusive license to develop and commercialize tenapanor in China for the treatment,
diagnosis  or  prevention  of 
idiopathic  constipation,
hyperphosphatemia  related  to  chronic  kidney  disease,  and  other  diseases  or  conditions  for  which  we  obtain  marketing
approval in either the US or China (collectively, “the Fosun Field”). The Fosun Field excludes the treatment of cancer. We
retained the rights to tenapanor outside of China, and also retained the rights to tenapanor in China for indications other
than those in the Fosun Field. Pursuant to the terms of the Fosun License Agreement, Fosun Pharma is responsible for all
development and commercialization costs for tenapanor in the Fosun Field in China.

irritable  bowel  syndrome  with  constipation  and  chronic 

Under  the  terms  of  the  Fosun  License  Agreement,  we  are  responsible  for  supplying  the  tenapanor  drug  product  for
Fosun  Pharma’s  use  in  development  and  during  commercialization  until  Fosun  Pharma  has  assumed  such  responsibility.
Additionally, we are responsible for supplying the tenapanor drug substance for Fosun Pharma’s use in development and
commercialization throughout the term of the Fosun License Agreement.

Under the terms of the Fosun License Agreement, we received an upfront payment of $12.0 million and are eligible to
receive  additional  milestones  of  up  to  $113.0  million  in  the  aggregate,  of  which  we  have  recognized  and  received  $3.0
million  to  date,  as  well  as  tiered  royalty  payments  on  aggregate  net  sales  ranging  from  the  mid-teens  percent  to  twenty
percent, subject to certain reductions under certain circumstances, as described in the Fosun License Agreement.

The  Fosun  License  Agreement  will  continue  until  all  of  Fosun  Pharma’s  applicable  payment  obligations  under  the
License Agreement have been performed or have expired, or the agreement is earlier terminated. Under the terms of the
Fosun License Agreement, we and Fosun Pharma each have the right to terminate the agreement for material breach by the
other party or in the event of insolvency by the other party. In addition, Fosun Pharma may terminate the agreement for
convenience,  and  we  may  terminate  the  agreement  if  Fosun  Pharma  challenges  any  patents  licensed  to  it  under  the
agreement.

License Agreement with Knight Therapeutics

In  March  2018,  we  entered  into  a  license  agreement  with  Knight  (“the  Knight  License  Agreement”)  that  provides
Knight  with  exclusive  rights  to  commercialize  tenapanor  in  Canada.  Under  the  terms  of  the  Knight  License  Agreement,
Ardelyx is eligible to receive up to CAD 25 million in total payments, worth up to $19.6 million at the currency exchange
rate on December 31, 2020, including an upfront payment and development and sales milestones, as well as tiered royalties
on net sales ranging from the mid-single digits to the low twenties. As of December 31, 2020, we have recognized and

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received  $3.1  million  to  date  under  the  Knight  License  Agreement.  Knight  has  the  exclusive  rights  to  market  and  sell
tenapanor in Canada.

CORPORATE DEVELOPMENT

In July 2020, we filed a Form S-3 registration statement, which became effective in August 2020, containing (i) a base
prospectus  for  the  offering,  issuance  and  sale  by  the  Company  of  up  to  a  maximum  aggregate  offering  price  of  $250.0
million of the Company’s common stock, preferred stock, debt securities, warrants and/or units, from time to time in one or
more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by the Company of up to a maximum
aggregate offering price of $100.0 million of our common stock that may be issued and sold, from time to time, under an
Open Market Sales Agreement with Jefferies LLC, as sales agent, deemed to be “at the market offerings.” As of December
31, 2020, we had sold 3.3 million shares of our common stock for aggregate gross proceeds of $21.7 million at a weighted
average  price  of  $6.65  per  share  under  the  Open  Market  Sales  Agreement.  From  the  period  of  January  2,  2021  through
February 28, 2021, we sold an additional 4.9 million shares of our common stock for aggregate gross proceeds of $35.0
million at a weighted average price of $7.09 per share. In aggregate during the life of the Open Market Sales Agreement,
we have sold 8.2 million shares of our common stock for aggregate gross proceeds of $56.7 million at a weighted average
sales  price  of  approximately  $6.91  per  share.  Pursuant  to  the  Open  Market  Sales  Agreement,  Jefferies,  as  sales  agent,
receives a commission of up to 3.0% of the gross sales price for shares of common stock sold under the Open Market Sales
Agreement.

In December 2019, we completed an underwritten public offering of 23.0 million shares of common stock, resulting in
the  receipt  of  aggregate  gross  proceeds  of  approximately  $143.8  million,  less  underwriting  discounts,  commissions  and
offering expenses totaling approximately $8.9 million, which resulted in net proceeds of approximately $134.9 million.

In November 2019, we enhanced our strategic partnership with KKC by entering into a Stock Purchase Agreement,
pursuant to which we sold to KKC an aggregate of 2.9 million shares of our common stock for aggregate gross proceeds of
approximately $20.0 million.

As of December 31, 2020, we had cash, cash equivalents and investments totaling $188.6 million.

INTELLECTUAL PROPERTY

Our  commercial  success  depends  in  part  on  our  ability  to  obtain  and  maintain  proprietary  protection  for  our  drug
candidates,  manufacturing  and  process  discoveries,  and  other  know-how,  to  operate  without  infringing  the  proprietary
rights of others and to prevent others from infringing our proprietary rights. Our policy is to seek to protect our intellectual
property  by,  among  other  methods,  filing  U.S.  and  foreign  patent  applications  related  to  our  proprietary  technology  and
inventions that are important to the development and operation of our business. We also rely on trade secrets and careful
monitoring  of  our  proprietary  information  to  protect  aspects  of  our  business  that  are  not  amenable  to,  or  that  we  do  not
consider appropriate for, patent protection.

The  patent  positions  of  biopharmaceutical  companies  like  us  are  generally  uncertain  and  involve  complex  legal,
scientific  and  factual  questions.  In  addition,  the  coverage  claimed  in  a  patent  application  can  be  significantly  reduced
before the patent is issued, and its scope can be reinterpreted after issuance. Consequently, we do not know whether any of
our  product  candidates  will  be  protectable  or  remain  protected  by  enforceable  patents.  We  cannot  predict  whether  the
patent applications we are currently pursuing will issue as patents in any particular jurisdiction or whether the claims of our
issued patents will provide sufficient proprietary protection from competitors. Any patents that we hold may be challenged,
circumvented or invalidated by third parties. If third parties prepare and file patent applications in the United States that
also claim technology or therapeutics to which we have rights, we may have to participate in interference proceedings in
the U.S. Patent and Trademark Office (the “USPTO”) to determine priority of invention, which would result in substantial
costs to us even if the eventual outcome is favorable to us.

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The term of individual patents depends upon the legal term of the patents in countries in which they are obtained. In
most  countries,  including  the  United  States,  the  patent  term  is  generally  20  years  from  the  earliest  date  of  filing  a  non-
provisional patent application in the applicable country. In the U.S., a patent’s term may, in certain cases, be lengthened by
patent term adjustment, which compensates a patentee for administrative delays by the USPTO in examining and granting
a  patent,  or  may  be  shortened  if  a  patent  is  terminally  disclaimed  over  a  commonly  owned  patent  or  a  patent  naming  a
common inventor and having an earlier expiration date.

In addition, in the United States, the Hatch-Waxman Act permits a patent term extension of up to five years beyond the
expiration  of  a  U.S.  patent  as  partial  compensation  for  the  patent  term  lost  during  the  FDA  regulatory  review  process
occurring while the patent is in force. A patent extension cannot extend the remaining term of a patent beyond a total of
14  years  from  the  date  of  product  approval,  and  only  one  patent  applicable  to  each  regulatory  review  period  may  be
extended and only those claims covering the approved drug, a method for using it or a method for manufacturing it may be
extended. Similar provisions are available in the European Union and certain other foreign jurisdictions to extend the term
of a patent that covers an approved drug.

We may rely, in some circumstances, on trade secrets to protect our technology. Although we take steps to protect our
proprietary information and trade secrets, including through contractual means with our employees and consultants, third
parties  may  independently  develop  substantially  equivalent  proprietary  information  and  techniques  or  otherwise  gain
access to our trade secrets or disclose our technology. Thus, we may not be able to meaningfully protect our trade secrets. It
is  our  policy  to  require  our  employees,  consultants,  outside  scientific  collaboration  partners,  sponsored  researchers  and
other advisors to execute confidentiality agreements upon the commencement of employment or consulting relationships
with us. These agreements provide that all confidential information concerning the business or financial affairs developed
or made known to the individual during the course of the individual’s relationship with us is to be kept confidential and not
disclosed  to  third  parties  except  in  specific  circumstances.  In  the  case  of  employees,  the  agreements  provide  that  all
inventions  conceived  by  the  individual,  and  which  are  related  to  our  current  or  planned  business  or  research  and
development  or  made  during  the  normal  working  hours,  on  our  premises  or  using  our  equipment  or  proprietary
information, are our exclusive property.

Tenapanor Patents

Our  tenapanor  patent  portfolio  is  wholly  owned  by  us.  This  portfolio  includes  five  issued  U.S.  patents,  three  issued
Israeli patents, two issued patents in each of Japan, Korea, Hong Kong and Mexico and one issued patent in each of the
following territories: Australia, Brazil, India, China, and the European Patent Organization countries. These issued patents
cover the composition and certain methods of using tenapanor and are predicted, without extension or adjustment, to expire
in  December  2029.  The  portfolio  further  includes  patents  covering  the  use  of  tenapanor  for  the  control  of  serum
phosphorus  that  has  issued  in  the  U.S.,  Europe,  Japan,  China,  Australia,  Gulf  Co-op  countries,  Hong  Kong,  Russia  and
Taiwan and is pending in other countries. These patents are predicted, without extension or adjustment, to expire in April
2034.

Additional  U.S.  and  international  patent  applications  are  pending  covering  additional  methods  of  treatment  with
tenapanor, and composition of matter and methods of using compounds that we believe may be follow on compounds to
tenapanor.

Other Program Patents

We have patent applications pending in the U.S. and internationally that cover the compositions and methods of using

compounds in our RDX013 program.

MANUFACTURING

To  date,  we  have  relied  upon  third-party  contract  manufacturing  organizations  (“CMOs”)  to  manufacture  both  the
active pharmaceutical ingredient and final drug product dosage forms of our potential drug candidates used as clinical trial
material. We expect that we will continue to rely upon CMOs for the manufacture of our clinical trial materials and for

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our  commercial  product  requirements,  when  and  if  regulatory  approval  is  received.  Our  license  agreements  with  KKC,
Knigh, and Fosun Pharma require us to supply final drug product dosage forms of tenapanor and/or active pharmaceutical
ingredient for their use in the development of tenapanor in each of their respective territories, and we are further obligated
to  continue  to  supply  active  pharmaceutical  ingredient  to  support  their  commercialization  of  tenapanor  in  each  of  their
territories. We expect that we will use CMOs to satisfy our supply obligations to our collaboration partners.

GOVERNMENT REGULATION

The  FDA  and  comparable  regulatory  authorities  in  state  and  local  jurisdictions  and  in  other  countries  impose
substantial and burdensome requirements upon companies involved in the clinical development, manufacture, marketing
and  distribution  of  drugs.  These  agencies  and  other  federal,  state  and  local  entities  regulate  research  and  development
activities  and  the  testing,  manufacture,  quality  control,  safety,  effectiveness,  labeling,  storage,  record  keeping,  approval,
advertising and promotion, distribution, post-approval monitoring and reporting, sampling, and export and import of our
product candidates.

In  the  United  States,  the  FDA  regulates  drug  products  under  the  Federal  Food,  Drug,  and  Cosmetic  Act  (the
“FFDCA”) and the FDA’s implementing regulations. If we fail to comply with applicable FDA or other requirements at
any  time  during  the  drug  development  process,  the  approval  process  or  after  approval,  we  may  become  subject  to
administrative  or  judicial  sanctions.  These  sanctions  could  include  the  FDA’s  refusal  to  approve  pending  applications,
license suspension or revocation, withdrawal of an approval, warning or untitled letters, product recalls, product seizures,
total or partial suspension of production or distribution, injunctions, fines, civil penalties or criminal prosecution. Any FDA
enforcement action could have a material adverse effect on us. FDA approval is required before any new unapproved drug
or dosage form, including a new use of a previously approved drug, can be marketed in the United States.

The process required by the FDA before a drug may be marketed in the United States generally involves:

● completion  of  extensive  preclinical  laboratory  tests,  preclinical  animal  studies  and  formulation  studies,  some

performed in accordance with the FDA’s current Good Laboratory Practice (“GLP”) regulations;

● submission to the FDA of an Investigational New Drug (“IND”) application which must become effective before

human clinical trials in the United States may begin;

● approval  by  an  independent  institutional  review  board,  (“IRB”)  or  ethics  committee  at  each  clinical  trial  site

before each trial may be initiated;

● performance of adequate and well-controlled human clinical trials in accordance with Good Clinical Practice, or

GCP, regulations to establish the safety and efficacy of the drug candidate for each proposed indication;

● submission to the FDA of a new drug application (“NDA”);

● satisfactory  completion  of  an  FDA  inspection  of  the  manufacturing  facility  or  facilities  at  which  the  drug  is

produced to assess compliance with current Good Manufacturing Practice (“cGMP”) regulations;

● satisfactory completion of a potential review by an FDA advisory committee, if applicable; and

● FDA review and approval of the NDA prior to any commercial marketing, sale or commercial shipment of the

drug.

The preclinical and clinical testing and approval process requires substantial time, effort and financial resources, and
we cannot be certain that any approvals for our product candidates will be granted on a timely basis, if at all. Nonclinical
tests include laboratory evaluation of product chemistry, formulation, stability and toxicity, as well as animal studies to

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assess  the  characteristics  and  potential  safety  and  efficacy  of  the  product.  The  results  of  preclinical  tests,  together  with
manufacturing information, analytical data and a proposed clinical trial protocol and other information, are submitted as
part  of  an  IND  to  the  FDA.  Additional  preclinical  testing  may  continue  even  after  the  IND  is  submitted.  The  IND
automatically  becomes  effective  30  days  after  receipt  by  the  FDA,  unless  the  FDA,  within  the  30-day  period,  raises
concerns  or  questions  relating  to  the  IND  and  places  the  clinical  trial  on  a  clinical  hold,  including  concerns  that  human
research subjects will be exposed to unreasonable health risks. In such a case, the IND sponsor and the FDA must resolve
any outstanding concerns before the clinical trial can begin. A separate submission to an existing IND must also be made
for each successive clinical trial conducted during product development.

Clinical  trials  involve  the  administration  of  the  investigational  drug  to  human  subjects  under  the  supervision  of
qualified  investigators.  Clinical  trials  are  conducted  under  protocols  detailing,  among  other  things,  the  objectives  of  the
clinical trial, the parameters to be used in monitoring safety and the effectiveness criteria to be used. Each protocol must be
submitted to the FDA as part of the IND.

An independent IRB or ethics committee for each medical center proposing to conduct a clinical trial must also review
and approve a plan for any clinical trial before it can begin at that center and the IRB must monitor the clinical trial until it
is completed. The FDA, the IRB, or the sponsor may suspend or discontinue a clinical trial at any time on various grounds,
including  a  finding  that  the  subjects  are  being  exposed  to  an  unacceptable  health  risk.  Clinical  testing  also  must  satisfy
extensive GCP requirements, including the requirements for informed consent.

All clinical research performed in the United States in support of an NDA must be submitted in advance by the FDA
under  the  IND  regulations  and  procedures  described  above.  However,  a  sponsor  who  wishes  to  conduct  a  clinical  trial
outside  the  United  States  may,  but  need  not,  obtain  FDA  authorization  to  conduct  the  clinical  trial  under  an  IND.  If  a
foreign  clinical  trial  is  not  conducted  under  an  IND,  the  sponsor  may  submit  data  from  the  clinical  trial  to  the  FDA  in
support of an NDA so long as the clinical trial is conducted in compliance with GCP and if the FDA is able to validate the
data from the study through an onsite inspection, if necessary. GCP includes review and approval by an independent ethics
committee, such as an IRB, and obtaining and documenting the freely given informed consent of the subject before study
initiation. If the applicant seeks approval of an NDA solely on the basis of foreign data, the FDA will only accept such data
if  they  are  applicable  to  the  U.S.  population  and  U.S.  medical  practice,  the  studies  have  been  performed  by  clinical
investigators of recognized competence, and the data may be considered valid without the need for an on-site inspection by
the FDA, or if the FDA considers such an inspection to be necessary, the FDA is able to validate the data through an on-
site inspection or through other appropriate means.

Clinical Trials

The  clinical  investigation  of  a  new  drug  is  typically  conducted  in  three  or  four  phases,  which  may  overlap  or  be

combined, and generally proceed as follows.

● Phase 1: Clinical trials are initially conducted in a limited population of subjects to test the drug candidate for
safety, dose tolerance, absorption, metabolism, distribution and excretion in healthy humans or, on occasion, in
patients with severe problems or life-threatening diseases to gain an early indication of its effectiveness.

● Phase 2: Clinical trials are generally conducted in a limited patient population to evaluate dosage tolerance and
appropriate dosage, identify possible adverse effects and safety risks, and evaluate preliminarily the efficacy of
the drug for specific targeted indications in patients with the disease or condition under study.

● Phase 3: Clinical trials are typically conducted when Phase 2 clinical trials demonstrate that a dose range of the
product candidate is effective and has an acceptable safety profile. Phase 3 clinical trials are commonly referred
to as “pivotal” studies, which typically denotes a study which presents the data that the FDA or other relevant
regulatory  agency  will  use  to  determine  whether  or  not  to  approve  a  drug.  Phase  3  clinical  trials  are  generally
undertaken with large numbers of patients, such as groups of several hundred to several thousand, to further

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evaluate dosage, to provide substantial evidence of clinical efficacy and to further test for safety in an expanded
and diverse patient population at multiple, geographically-dispersed clinical trial sites.

● Phase 4: In some cases, the FDA may condition approval of an NDA for a product candidate on the sponsor’s
agreement  to  conduct  additional  clinical  trials  after  NDA  approval.  In  other  cases,  a  sponsor  may  voluntarily
conduct additional clinical trials post approval to gain more information about the drug. Such post approval trials
are typically referred to as Phase 4 clinical trials.

Concurrent  with  clinical  trials,  companies  usually  complete  additional  nonclinical  studies  and  must  also  develop
additional information about the chemistry and physical characteristics of the drug and finalize a process for manufacturing
the drug in commercial quantities in accordance with GMP requirements. The manufacturing process must be capable of
consistently  producing  quality  batches  of  the  drug  candidate  and,  among  other  things,  the  manufacturer  must  develop
methods for testing the identity, strength, quality and purity of the final drug product. Additionally, appropriate packaging
must  be  selected  and  tested,  and  stability  studies  must  be  conducted  to  demonstrate  that  the  drug  candidate  does  not
undergo unacceptable deterioration over its shelf life.

The FDA, the IRB or the clinical trial sponsor may suspend or terminate a clinical trial at any time on various grounds,

including a finding that the research subjects are being exposed to an unacceptable health risk.

Additionally, some clinical trials are overseen by an independent group of qualified experts organized by the clinical
trial sponsor, known as a data safety monitoring board or committee. This group provides authorization for whether or not
a trial may move forward at designated check points based on access to certain data from the study. We may also suspend
or terminate a clinical trial based on evolving business objectives and/or competitive climate.

New Drug Applications

The results of preclinical studies and of the clinical trials, together with other detailed information, including extensive
manufacturing information and information on the composition of the drug, are submitted to the FDA in the form of an
NDA  requesting  approval  to  market  the  drug  for  one  or  more  specified  indications.  The  FDA  reviews  an  NDA  to
determine, among other things, whether a drug is safe and effective for its intended use.

Under  the  Prescription  Drug  User  Fee  Act,  the  FDA  has  a  goal  of  responding  to  standard  review  NDAs  of  new
molecular  entities  within  ten  months  after  the  60-day  filing  review  period,  or  six  months  after  the  60-day  filing  review
period  for  priority  review  NDAs,  but  this  timeframe  is  often  extended  by  FDA  requests  for  additional  information  or
clarification. The FDA may refer the application to an advisory committee for review, evaluation and recommendation as
to whether the application should be approved. The FDA is not bound by the recommendation of an advisory committee,
but it generally follows such recommendations.

Before approving an application, the FDA may inspect the facility or the facilities at which the finished drug product,
and sometimes the active pharmaceutical ingredient (“API”) is manufactured, and will not approve the drug unless cGMP
compliance is satisfactory. The FDA may also inspect the sites at which the clinical trials were conducted to assess their
compliance and will not approve the drug unless compliance with cGCP requirements is satisfactory.

After the FDA evaluates the NDA and conducts inspections of manufacturing facilities where the drug product and/or
its API will be produced, if deemed necessary, it may issue an approval letter or a Complete Response Letter. An approval
letter  authorizes  commercial  marketing  of  the  drug  with  specific  prescribing  information  for  specific  indications.  A
Complete Response Letter indicates that the review cycle of the application is complete, and the application is not ready for
approval.  A  Complete  Response  Letter  may  require  additional  clinical  data  and/or  an  additional  pivotal  Phase  3  clinical
trial(s), and/or other significant, expensive and time-consuming requirements related to clinical trials, preclinical studies or
manufacturing. Even if such additional information is submitted, the FDA may ultimately decide that the NDA does not
satisfy  the  criteria  for  approval.  The  FDA  could  also  approve  the  NDA  with  a  Risk  Evaluation  and  Mitigation  Strategy
(“REMS”) to mitigate risks, which could include medication guides, physician communication plans, or elements to assure

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safe use, such as restricted distribution methods, patient registries and other risk minimization tools. The FDA also may
condition  approval  on,  among  other  things,  changes  to  proposed  labeling,  development  of  adequate  controls  and
specifications, or a commitment to conduct one or more post-market studies or clinical trials. Such post-market testing may
include  Phase  4  clinical  trials  and  surveillance  to  further  assess  and  monitor  the  product’s  safety  and  effectiveness  after
commercialization. The FDA has the authority to prevent or limit further marketing of a drug based on the results of these
post-marketing programs. Once the FDA approves an NDA, or supplement thereto, the FDA may withdraw the approval if
ongoing regulatory requirements are not met or if safety problems are identified after the drug reaches the market.

Drugs may be marketed only for the FDA approved indications and in accordance with the provisions of the approved
labeling. Further, if there are any modifications to the drug, including changes in indications, labeling, or manufacturing
processes  or  facilities,  the  applicant  may  be  required  to  submit  and  obtain  FDA  approval  of  a  new  NDA  or  NDA
supplement,  which  may  require  the  applicant  to  develop  additional  data  or  conduct  additional  preclinical  studies  and
clinical trials.

The  testing  and  approval  processes  require  substantial  time,  effort  and  financial  resources,  and  each  may  take
several years to complete. The FDA may not grant approval on a timely basis, or at all. Even if we believe a clinical trial
has  demonstrated  safety  and  efficacy  of  one  of  our  drug  candidates  for  the  proposed  indication,  the  results  may  not  be
satisfactory to the FDA. Nonclinical and clinical data may be interpreted by the FDA in different ways, which could delay,
limit or prevent regulatory approval. We may encounter difficulties or unanticipated costs in our efforts to secure necessary
governmental approvals which could delay or preclude us from marketing drugs. The FDA may limit the indications for
use or place other conditions on any approvals that could restrict the commercial application of the drugs. After approval,
certain changes to the approved drug, such as adding new indications, manufacturing changes, or additional labeling claims
are  subject  to  further  FDA  review  and  approval.  Depending  on  the  nature  of  the  change  proposed,  an  NDA  supplement
must be filed and approved before the change may be implemented.

Other Regulatory Requirements

Any  drugs  manufactured  or  distributed  by  us  or  our  collaboration  partners  pursuant  to  FDA  approvals  would  be
subject to continuing regulation by the FDA, including recordkeeping requirements and reporting of adverse experiences
associated with the drug. Drug manufacturers and their subcontractors are required to register their establishments with the
FDA and certain state agencies and are subject to periodic announced and unannounced inspections by the FDA and certain
state agencies for compliance with ongoing regulatory requirements, including cGMP, which impose certain procedural and
documentation requirements upon us and our third-party manufacturers. Failure to comply with the statutory and regulatory
requirements  can  subject  a  manufacturer  to  possible  legal  or  regulatory  action,  such  as  warning  or  untitled  letters,
suspension of manufacturing, seizure of product, injunctive action or possible civil penalties. We cannot be certain that we
or our present or future third-party manufacturers or suppliers will be able to comply with the cGMP regulations and other
ongoing FDA regulatory requirements. If we or our present or future third-party manufacturers or suppliers are not able to
comply with these requirements, the FDA may, among other things, halt our clinical trials, require us to recall a drug from
distribution or withdraw approval of the NDA for that drug.

The FDA closely regulates the post-approval marketing and promotion of drugs, including standards and regulations
for  direct-to-consumer  advertising,  off-label  promotion,  industry-sponsored  scientific  and  educational  activities  and
promotional activities involving the Internet. A company can make only those claims relating to safety and efficacy that are
in the final label or consistent with the final label. Failure to comply with these requirements can result in, among other
things,  adverse  publicity,  warning  or  untitled  letters,  corrective  advertising  and  potential  civil  and  criminal  penalties.
Physicians  may  prescribe  legally  available  drugs  for  uses  that  are  not  described  in  the  product’s  labeling  and  that  differ
from those tested by us and approved by the FDA. Such off-label uses are common across medical specialties. Physicians
may believe that such off-label uses are the best treatment for many patients in varied circumstances. The FDA does not
regulate the behavior of physicians in their choice of treatments. The FDA does, however, impose stringent restrictions on
manufacturers’ communications regarding off-label use.

Hatch-Waxman Act

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Section  505  of  the  FFDCA  describes  three  types  of  marketing  applications  that  may  be  submitted  to  the  FDA  to
request marketing authorization for a new drug. A Section 505(b)(1) NDA is an application that contains full reports of
investigations of safety and efficacy. A 505(b)(2) NDA is an application that contains full reports of investigations of safety
and  efficacy  but  where  at  least  some  of  the  information  required  for  approval  comes  from  investigations  that  were  not
conducted by or for the applicant and for which the applicant has not obtained a right of reference or use from the person
by or for whom the investigations were conducted. This regulatory pathway enables the applicant to rely, in part, on the
FDA’s  prior  findings  of  safety  and  efficacy  for  an  existing  product,  or  published  literature,  in  support  of  its  application.
Section  505(j)  establishes  an  abbreviated  approval  process  for  a  generic  version  of  approved  drug  products  through  the
submission  of  an  Abbreviated  New  Drug  Application  (“ANDA”).  An  ANDA  provides  for  marketing  of  a  generic  drug
product  that  has  the  same  active  ingredients,  dosage  form,  strength,  route  of  administration,  labeling,  performance
characteristics and intended use, among other things, to a previously approved product. ANDAs are termed “abbreviated”
because they are generally not required to include nonclinical (animal) and clinical (human) data to establish safety and
efficacy. Instead, generic applicants must scientifically demonstrate that their product is bioequivalent to, or performs in the
same manner as, the innovator drug through in vitro, in vivo, or other testing. The generic version must deliver the same
amount of active ingredients into a subject’s bloodstream in the same amount of time as the innovator drug and can often
be  substituted  by  pharmacists  under  prescriptions  written  for  the  reference  listed  drug.  In  seeking  approval  for  a  drug
through an NDA, applicants are required to list with the FDA each patent with claims that cover the applicant’s drug or a
method  of  using  the  drug.  Upon  approval  of  a  drug,  each  of  the  patents  listed  in  the  application  for  the  drug  is  then
published  in  the  FDA’s  Approved  Drug  Products  with  Therapeutic  Equivalence  Evaluations,  commonly  known  as  the
Orange Book. Drugs listed in the Orange Book can, in turn, be cited by potential competitors in support of approval of an
ANDA or 505(b)(2) NDA.

Upon  submission  of  an  ANDA  or  a  505(b)(2)  NDA,  an  applicant  must  certify  to  the  FDA  that  (1)  no  patent
information on the drug product that is the subject of the application has been submitted to the FDA; (2) such patent has
expired;  (3)  the  date  on  which  such  patent  expires;  or  (4)  such  patent  is  invalid  or  will  not  be  infringed  upon  by  the
manufacture,  use  or  sale  of  the  drug  product  for  which  the  application  is  submitted.  Generally,  the  ANDA  or  505(b)
(2) NDA cannot be approved until all listed patents have expired, except where the ANDA or 505(b)(2) NDA applicant
challenges a listed patent through the last type of certification, also known as a paragraph IV certification. If the applicant
does not challenge the listed patents or indicates that it is not seeking approval of a patented method of use, the ANDA or
505(b)(2) NDA application will not be approved until all of the listed patents claiming the referenced product have expired.

If the ANDA or 505(b)(2) NDA applicant has provided a Paragraph IV certification to the FDA, the applicant must
send  notice  of  the  Paragraph  IV  certification  to  the  NDA  and  patent  holders  once  the  application  has  been  accepted  for
filing by the FDA. The NDA and patent holders may then initiate a patent infringement lawsuit in response to the notice of
the  paragraph  IV  certification.  If  the  paragraph  IV  certification  is  challenged  by  an  NDA  holder  or  the  patent
owner(s) asserts a patent challenge to the paragraph IV certification, the FDA may not approve that application until the
earlier of 30 months from the receipt of the notice of the paragraph IV certification, the expiration of the patent, when the
infringement case concerning each such patent was favorably decided in the applicant’s favor or settled, or such shorter or
longer  period  as  may  be  ordered  by  a  court.  This  prohibition  is  generally  referred  to  as  the  30-month  stay.  In  instances
where  an  ANDA  or  505(b)(2)  NDA  applicant  files  a  paragraph  IV  certification,  the  NDA  holder  or  patent
owner(s)  regularly  take  action  to  trigger  the  30-month  stay,  recognizing  that  the  related  patent  litigation  may  take
many months or years to resolve. Thus, approval of an ANDA or 505(b)(2) NDA could be delayed for a significant period
of  time  depending  on  the  patent  certification  the  applicant  makes  and  the  reference  drug  sponsor’s  decision  to  initiate
patent litigation.

The Hatch-Waxman Act establishes periods of regulatory exclusivity for certain approved drug products, during which
the FDA cannot approve (or in some cases accept) an ANDA or 505(b)(2) application that relies on the branded reference
drug. For example, the holder of an NDA, including a 505(b)(2) NDA, may obtain five years of exclusivity upon approval
of a new drug containing new chemical entities (“NCE”) that have not been previously approved by the FDA. A drug is a
new chemical entity if the FDA has not previously approved any other new drug containing the same active moiety, which
is the molecule or ion responsible for the therapeutic activity of the drug substance. During the exclusivity period, the FDA
may not accept for review an ANDA or a 505(b)(2) NDA submitted by another company that contains

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the  previously  approved  active  moiety.  However,  an  ANDA  or  505(b)(2)  NDA  may  be  submitted  after  four  years  if  it
contains a certification of patent invalidity or non-infringement.

The  Hatch-Waxman  Act  also  provides  three  years  of  marketing  exclusivity  to  the  holder  of  an  NDA  (including  a
505(b)(2) NDA) for a particular condition of approval, or change to a marketed product, such as a new formulation for a
previously approved product, if one or more new clinical studies (other than bioavailability or bioequivalence studies) was
essential  to  the  approval  of  the  application  and  was  conducted/sponsored  by  the  applicant.  This  three-year  exclusivity
period protects against FDA approval of ANDAs and 505(b)(2) NDAs for the condition of the new drug’s approval. As a
general  matter,  the  three-year  exclusivity  does  not  prohibit  the  FDA  from  approving  ANDAs  or  505(b)(2)  NDAs  for
generic  versions  of  the  original,  unmodified  drug  product.  Five-year  and  three-year  exclusivity  will  not  delay  the
submission  or  approval  of  a  full  NDA;  however,  an  applicant  submitting  a  full  NDA  would  be  required  to  conduct  or
obtain  a  right  of  reference  to  all  of  the  preclinical  studies  and  adequate  and  well-controlled  clinical  trials  necessary  to
demonstrate safety and efficacy.

Fraud and Abuse Laws

In  the  U.S.  the  research,  manufacturing,  distribution,  sale  and  promotion  of  drug  products  and  medical  devices  are
potentially subject to regulation by various federal, state and local authorities in addition to the FDA, including the Centers
for Medicare & Medicaid Services (“CMS”) other divisions of the U.S. Department of Health and Human Services (e.g.,
the  Office  of  Inspector  General),  the  U.S.  Department  of  Justice,  state  Attorneys  General,  and  other  state  and  local
government agencies. These laws include but are not limited to, the Anti-Kickback Statute, the federal False Claims Act,
the federal Physician Payments Sunshine Act, and other state and federal laws and regulations.

The  Anti-Kickback  Statute  makes  it  illegal  for  any  person,  including  a  prescription  drug  manufacturer  (or  a  party
acting on its behalf) to knowingly and willfully solicit, receive, offer, or pay any remuneration that is intended to induce the
referral of business, including the purchase, order, or prescription of a particular drug, for which payment may be made
under a federal healthcare program, such as Medicare or Medicaid. Violations of this law are punishable by up to five years
in  prison,  criminal  fines,  administrative  civil  money  penalties,  and  exclusion  from  participation  in  federal  healthcare
programs. In addition, a person or entity does not need to have actual knowledge of the statute or specific intent to violate it
in order to have committed a violation.

The federal False Claims Act prohibits anyone from knowingly presenting, or causing to be presented, for payment to
federal  programs  (including  Medicare  and  Medicaid)  claims  for  items  or  services,  including  drugs,  that  are  false  or
fraudulent,  claims  for  items  or  services  not  provided  as  claimed,  or  claims  for  medically  unnecessary  items  or  services.
Although  we  would  not  submit  claims  directly  to  payors,  manufacturers  can  be  held  liable  under  these  laws  if  they  are
deemed  to  “cause”  the  submission  of  false  or  fraudulent  claims  by,  for  example,  providing  inaccurate  billing  or  coding
information  to  customers  or  promoting  a  product  off-label.  In  addition,  our  future  activities  relating  to  the  reporting  of
wholesaler or estimated retail prices for our products, the reporting of prices used to calculate Medicaid rebate information
and other information affecting federal, state, and third-party reimbursement for our products, and the sale and marketing
of our products, are subject to scrutiny under this law. Moreover, the government may assert that a claim including items or
services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes
of the False Claims Act. Penalties for a False Claims Act violation include three times the actual damages sustained by the
government, plus mandatory civil penalties for each separate false claim, the potential for exclusion from participation in
federal healthcare programs. As well, although the federal False Claims Act is a civil statute, conduct that results in a False
Claims Act violation may also implicate various federal criminal statutes. If the government were to allege that we were, or
convict us of, violating these false claims laws, we could be subject to a substantial fine and may suffer a decline in our
stock price. In addition, private individuals have the ability to bring actions under the federal False Claims Act.

In  addition  to  the  laws  described  above,  the  Patient  Protection  and  Affordable  Care  Act,  as  amended  by  the  Health
Care  and  Education  Reconciliation  Act,  collectively  known  as  the  Affordable  Care  Act,  also  imposed  new  reporting
requirements on drug manufacturers for payments made to physicians (defined to include doctors, dentists, optometrists,
podiatrists and chiropractors) and teaching hospitals, as well as ownership and investment interests held by such physicians

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and  their  immediate  family  members.  Beginning  in  2022,  such  obligations  will  include  payments  and  other  transfers  of
value  provided  in  the  previous  year  to  certain  other  healthcare  professionals,  including  physician  assistants,  nurse
practitioners, clinical nurse specialists, certified nurse anesthetists, anesthesiologist assistants and certified nurse midwives.
Failure  to  submit  required  information  may  result  in  significant  civil  monetary  penalties,  and  additional  penalties  for
knowing failures, for all payments, transfers of value or ownership or investment interests that are not timely, accurately
and completely reported in an annual submission. Manufacturers must submit reports by the 90th day of each subsequent
calendar year.

Many states have also adopted laws similar to the federal laws discussed above. Some of these state prohibitions apply
to the referral of patients for healthcare services reimbursed by any insurer, not just federal healthcare programs such as
Medicare and Medicaid. There has also been a recent trend of increased regulation of payments made to physicians and
other  healthcare  providers.  Certain  states  mandate  implementation  of  compliance  programs,  impose  restrictions  on  drug
manufacturers’ marketing practices and/or require the tracking and reporting of pricing and marketing information as well
as gifts, compensation and other remuneration to physicians. Many of these laws contain ambiguities as to what is required
to  comply  with  such  laws,  which  may  affect  our  sales,  marketing,  and  other  promotional  activities  by  imposing
administrative  and  compliance  burdens  on  us.  In  addition,  given  the  lack  of  clarity  with  respect  to  these  laws  and  their
implementation, our reporting actions could be subject to the penalty provisions of the pertinent state and perhaps federal,
authorities.

Violations  of  any  of  such  laws  or  any  other  governmental  regulations  that  apply  may  result  in  penalties,  including,
without  limitation,  administrative,  civil  and  criminal  penalties,  damages,  fines,  disgorgement,  the  curtailment  or
restructuring of operations, reporting obligations and integrity oversight, exclusion from participation in federal and state
healthcare programs and imprisonment.

Third-Party Coverage and Reimbursement

Sales  of  pharmaceutical  products  depend  in  significant  part  on  the  availability  of  coverage  and  adequate
reimbursement  by  third-party  payors,  such  as  state  and  federal  governments,  including  Medicare  and  Medicaid,  and
commercial  managed  care  providers.  In  the  United  States,  no  uniform  policy  of  coverage  and  reimbursement  for  drug
products  exists  among  third-party  payors.  Accordingly,  decisions  regarding  the  extent  of  coverage  and  amount  of
reimbursement to be provided for our product candidates, if approved, will be made on a payor by payor basis. As a result,
the coverage determination process is often a time-consuming and costly process that will require us to provide scientific
and clinical support for the use of our product candidates to each payor separately, with no assurance that coverage and
adequate reimbursement will be obtained. Third-party payors may limit coverage to specific drug products on an approved
list, or formulary, which might not include all of the FDA-approved drugs for a particular indication. A decision by a third-
party payor not to cover our product candidates could reduce physician utilization of our products once approved and have
a material adverse effect on our future sales, results of operations and financial condition. Moreover, a payor’s decision to
provide coverage for a drug product does not imply that an adequate reimbursement rate will be approved. Adequate third-
party reimbursement may not be available to enable us to maintain price levels sufficient to realize an appropriate return on
our investment in product development.

There  is  increased  uncertainty  related  to  insurance  coverage  and  reimbursement  for  certain  drugs,  like  tenapanor,
which, if approved, will be marketed for the control of serum phosphorus in CKD patients on dialysis. In January 2011,
CMS  implemented  a  new  prospective  payment  system  for  dialysis  treatment.  Under  the  ESRD  prospective  payment
system, CMS generally makes a single bundled payment to the dialysis facility for each dialysis treatment that covers all
items  and  services  routinely  required  for  dialysis  treatments  furnished  to  Medicare  beneficiaries  in  Medicare-certified
ESRD  facilities  or  at  their  home,  including  the  cost  of  certain  routine  drugs.  The  inclusion  of  oral  medications  without
  injectable  or  intravenous  equivalents  in  the  bundled  payment  was  initially  delayed  until  January  1,  2014  and  through
several subsequent legislative actions was delayed until January 1, 2025. As a result, absent further legislation or regulation
on this matter, beginning in 2025, oral ESRD-related drugs without injectable or intravenous equivalents may be included
in the ESRD bundle and separate Medicare payment for these drugs will no longer be available, as is the case today under
Medicare  Part  D.  While  it  is  too  early  to  project  the  full  impact  that  bundling  may  have  on  tenapanor  and  our  business
should tenapanor be brought into the bundle in 2025, or at any time,  we may be unable to sell tenapanor, if approved, to

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dialysis  providers  on  a  profitable  basis  if  third-party  payors  reduce  their  current  levels  of  payment,  or  if  our  costs  of
production  are  higher  than  levels  necessary  for  an  appropriate  gross  margin  after  payment  of  all  discounts,  rebates  and
 chargebacks.

Healthcare Reform

In  March  2010,  Congress  passed  the  Patient  Protection  and  Affordable  Care  Act,  a  healthcare  reform  measure  (the
“ACA”). The ACA was signed into law and substantially changed the way healthcare is financed by both governmental
and private insurers, and significantly impacted the pharmaceutical industry.

The  ACA  contained  a  number  of  provisions,  including  those  governing  enrollment  in  federal  healthcare  programs,
reimbursement changes and fraud and abuse measures, which have impacted existing government healthcare programs and
have  resulted  in  the  development  of  new  programs,  including  Medicare  payment  for  performance  initiatives  and
improvements to the physician quality reporting system and feedback program.

Additionally, the ACA:

● increased the minimum level of Medicaid rebates payable by manufacturers of brand-name drugs from 15.1% to

23.1% of the average manufacturer price;

● required collection of rebates for drugs paid by Medicaid managed care organizations;

● expanded  eligibility  criteria  for  Medicaid  programs  by,  among  other  things,  allowing  states  to  offer  Medicaid
coverage to additional individuals and by adding new mandatory eligibility categories for certain individuals with
income at or below 133% of the federal poverty level, thereby potentially increasing a manufacturer’s Medicaid
rebate liability;

● expanded  access  to  commercial  health  insurance  coverage  through  new  state-based  health  insurance

marketplaces, or exchanges;

● required manufacturers to participate in a coverage gap discount program, under which they must now agree to
offer 70% point-of-sale discounts off negotiated prices of applicable brand drugs to eligible beneficiaries during
their coverage gap period, as a condition for the manufacturer’s outpatient drugs to be covered under Medicare
Part D; and

● imposed  a  non-deductible  annual  fee  on  pharmaceutical  manufacturers  or  importers  who  sell  “branded

prescription drugs” to specified federal government programs.

In addition, other legislative changes have been proposed and adopted in the United States since the ACA was enacted.
For  example,  in  August  2011,  the  Budget  Control  Act  of  2011,  among  other  things,  included  aggregate  reductions  to
Medicare  payments  to  providers  of  2%  per  fiscal  year,  which  went  into  effect  on  April  1,  2013,  and,  due  to  subsequent
legislative  amendments,  will  remain  in  effect  through  2030,  with  the  exception  of  a  temporary  suspension  from  May  1,
2020 through March 31, 2021, unless additional Congressional action is taken. In January 2013, the American Taxpayer
Relief  Act,  among  other  things,  further  reduced  Medicare  payments  to  several  providers,  including  hospitals,  imaging
centers  and  cancer  treatment  centers,  and  increased  the  statute  of  limitations  period  for  the  government  to  recover
overpayments to providers from three to five years. Additionally, individual states have also become increasingly active in
passing  legislation  and  implementing  regulations  designed  to  control  pharmaceutical  product  pricing,  including  price  or
patient  reimbursement  constraints,  discounts,  restrictions  on  certain  product  access,  and  to  encourage  importation  from
other countries and bulk purchasing. Recently, there has also been heightened governmental scrutiny over the manner in
which drug manufacturers set prices for their marketed products, which has resulted in several Congressional inquiries and
proposed bills designed to, among other things, bring more transparency to product pricing, review the relationship

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between  pricing  and  manufacturer  patient  programs,  and  reform  government  program  reimbursement  methodologies  for
drug  products.  These  new  laws  and  the  regulations  and  policies  implementing  them,  as  well  as  other  healthcare  reform
measures that may be adopted in the future, may have a material adverse effect on our industry generally and on our ability
to successfully develop and commercialize our products.

Data Privacy and Security Laws

Numerous state, federal and foreign laws, including consumer protection laws and regulations, govern the collection,
dissemination, use, access to, confidentiality and security of personal information, including health-related information. In
the  United  States,  numerous  federal  and  state  laws  and  regulations,  including  data  breach  notification  laws,  health
information  privacy  and  security  laws,  including  the  Health  Insurance  Portability  and  Accountability  Act  of  1996,  as
amended, and regulations promulgated thereunder (collectively “HIPAA”), and federal and state consumer protection laws
and  regulations  (e.g.,  Section  5  of  the  Federal  Trade  Commission  Act),  that  govern  the  collection,  use,  disclosure,  and
protection of health-related and other personal information could apply to our operations or the operations of our partners.
In addition, certain state laws, such as the California Consumer Privacy Act (“CCPA”) and the California Privacy Rights
Act  (“CPRA”)  govern  the  privacy  and  security  of  personal  data,  including  health-related  data  in  certain  circumstances,
some of which are more stringent than HIPAA and many of which differ from each other in significant ways and may not
have the same effect, thus complicating compliance efforts. Failure to comply with these laws, where applicable, can result
in the imposition of significant civil and/or criminal penalties and private litigation. Privacy and security laws, regulations,
and other obligations are constantly evolving, may conflict with each other to complicate compliance efforts, and can result
in  investigations,  proceedings,  or  actions  that  lead  to  significant  civil  and/or  criminal  penalties  and  restrictions  on  data
processing.

Other Regulations

We  are  also  subject  to  numerous  federal,  state  and  local  laws  relating  to  such  matters  as  safe  working  conditions,
manufacturing practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous
substances. We may incur significant costs to comply with such laws and regulations now or in the future.

IMPACT OF COVID-19

The global COVID-19 pandemic has impacted the operational decisions of companies worldwide. It also has created
and  may  continue  to  create  significant  uncertainty  in  the  global  economy.  We  have  undertaken  measures  to  protect  our
employees, partners, collaborators, and vendors, some of which impact our normal operations. To date, we have been able
to continue our operations with our workforce, most of whom are working remotely, and our pre-existing infrastructure that
supports  secure  access  to  our  internal  systems.  If,  however,  the  COVID-19  pandemic  has  a  substantial  impact  on  the
productivity of our employees, our ability to successfully prepare for the commercial launch of tenapanor for the control of
serum phosphorous in CKD patients on dialysis, including our ability to hire and successfully integrate into the company
the new personnel required to prepare for such launch, or our ability to progress our research and development efforts, the
results of our operations and overall financial performance may be adversely impacted. The extent of the impact from the
COVID-19 pandemic on our business will depend largely on future developments that are highly uncertain and cannot be
predicted. For a discussion of risks of COVID-19 relating to our business, see “Item 1A. - Risk Factors- Risks Related to
Our Business- The ongoing COVID-19 pandemic, or any other outbreak of epidemic diseases, or the perception of their
effects, could have a material adverse effect on our business, financial condition, results of operations or cash flows. ” As
of the date of issuance of this financial report, we are not aware of any specific event or circumstance that would require
updates to our estimates and judgments or revisions to the carrying value of our assets or liabilities. These estimates may
change as new events occur and additional information is obtained.

HUMAN CAPITAL

The future success of our company depends on our ability to attract, retain, and further develop top talent. The PDUFA
date for our NDA for tenapanor for the control of serum phosphorus in CKD patients on dialysis is set for April 29, 2021,
and if approved, we expect to commercialize our first product in 2021. As a result, we are focused on building an

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experienced  commercial  team  and  expanding  our  internal  resources  to  support  a  commercial  organization.  During  this
ongoing transition and expansion our workforce, we remain steadfastly committed to our core values, including our goal to
develop and maintain an inclusive, diverse, and safe workplace with opportunities for our employees to grow and develop
in their careers, supported by strong compensation and benefits.

At December 31, 2020, we had approximately 129 full-time employees, 78 of whom were engaged directly in research
and development, and 51 in marketing, sales and administrative activities. During 2020, we increased our employee base
by approximately 41, or 47%.  

Inclusion and Diversity

Our  culture  is  supported  by  an  unwavering  commitment  to  inclusion  and  diversity.  As  of  December  31,  2020,
approximately  63.5%  of  our  workforce  was  female;  37%  of  our  executive  leadership  team  was  female  and  23%  of  our
employees in managerial roles were female. As of December 31, 2020, minorities represented approximately 59% of our
workforce, of which 19% of our employees in managerial roles were minorities. We strive to foster a culture where mutual
respect, inclusive behavior, and dignity are core to our individual expectations.

We  believe  that  our  success  will  be  significantly  impacted  by  our  ability  to  create  and  maintain  a  safe  inclusive
environment where everyone is empowered to do their best work—regardless of race, color, national origin, religion, sex,
sexual orientation, gender identity and expression, age, or disability. We are united by our desire to serve our patients, and
we are proud financial sponsors of the California Life Sciences Association Racial and Social Equity Initiative, a first step
in  a  unified  effort  for  the  life  sciences  industry  in  California  to  do  more  for  the  under-served  and  under-represented,
focusing  on  the  most  critical  need  to  address  the  inequality  for  Black,  Hispanic,  Native  American  and  Pacific  Islander
populations in California.  

Core Values

Fostering and maintaining a strong, healthy culture is a key strategic focus. Our core values reflect who we are and the
way  our  employees  interact  with  one  another,  our  partners  and  our  stockholders.  We  are  dedicated  to  our  core  values,
recognizing  that  this  dedication  will  foster  an  environment  where  we  will  be  able  to  realize  our  vision  of  creating  a
healthier tomorrow for patients with kidney and cardiovascular disease. We are Passionate, aware that with integrity and
determination, we make a difference for patients. We are Fearless, aware that by challenging convention, we truly innovate.
We are Dedicated, aware that working tirelessly together, we are greater than the sum of our parts. We are Inclusive, aware
that with respect, grace and humor, we are family. We encourage our employees to live out our core values and to discuss
our core values with potential candidates looking to join our team. We believe that this is an important step in helping our
culture stay strong and unique.

Health, Safety, and Wellness

The health, safety, and wellness of our employees is a priority in which we have always invested, and will continue to
do so. These investments and the prioritization of employee health, safety, and wellness took on particular significance in
2020  in  light  of  COVID-19.  In  response  to  the  COVID-19  pandemic,  we  implemented  significant  changes  that  we
determined were in the best interest of our employees, as well as the communities in which we operate, in compliance with
government regulations. This includes having the vast majority of our employees work from home, with a return to our
facility for a very limited number of lab-based employees and those needed to support them. To protect and support our
team  members  returning  to  our  facility,  we  have  implemented  health  and  safety  measures  that  included  maximizing
personal  workspaces,  changing  shift  schedules,  providing  personal  protective  equipment  (“PPE”),  and  instituting
mandatory  screening  before  accessing  buildings.  We  created  a  task  force  to  monitor  our  efforts  and  the  needs  of  our
employees.  

Compensation and Benefits

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We recognize that we operate within an industry where there is significant competition for top talent, and we endeavor
to provide not only a strong healthy culture, but also important compensation and benefits programs to help meet the needs
of our employees. In addition to base compensation, these programs, include annual bonuses, stock awards, an Employee
Stock  Purchase  Plan,  401(k),  healthcare  and  insurance  benefits,  health  savings  (funded  by  the  Company)  and  flexible
spending accounts, family leave, family care resources, and flexible work schedules, among many others. As a response to
the COVID-19 pandemic, we implemented payments to assist employees in paying for expenses incurred in working from
home.  

Ensuring  fair  and  equitable  pay  is  integral  to  our  commitment  to  our  employees.  Our  executive  team  and  Board  of
Directors strongly support this commitment. We conduct pay equity reviews annually to help us understand whether our
compensation structure is appropriate and to identify what improvements can be made.

CORPORATE INFORMATION

We  were  incorporated  in  Delaware  on  October  17,  2007,  under  the  name  Nteryx  and  changed  our  name  to
Ardelyx,  Inc.  in  June  2008.  We  operate  in  one  business  segment,  which  is  the  research  and  development  of
biopharmaceutical  products.  Our  principal  offices  are  located  at  34175  Ardenwood  Blvd.,  Fremont,  CA  94555  and  400
Fifth Avenue, Suite 210, Waltham, Massachusetts 02415. Our telephone number is (510) 745-1700 and our website address
is www.ardelyx.com.

We  file  electronically  with  the  Securities  and  Exchange  Commission  (“SEC”)  our  annual  reports  on  Form  10-K,
quarterly  reports  on  Form  10-Q  and  current  reports  on  Form  8-K  pursuant  to  Section  13(a)  or  15(d)  of  the  Securities
Exchange Act of 1934, as amended. We make available on our website at www.ardelyx.com, free of charge, copies of these
reports, as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC. The SEC
maintains a website that contains reports, proxy and information statements, and other information regarding issuers that
file electronically with the SEC. The address of that website is www.sec.gov.

ITEM 1A.    RISK FACTORS

Our business involves significant risks, some of which are described below. You should carefully consider these risks,
as well as other information in this Annual Report on Form 10-K, including our financial statements and the notes thereto
and “Management’s Discussion and Analysis of Financial Condition and Results of Operations.” The occurrence of any of
the events or developments described below could harm our business, financial condition, results of operations, cash flows,
the trading price of our common stock and our growth prospects. Many of the following risks and uncertainties are, and
will be, exacerbated by the COVID-19 pandemic and any worsening of the global business and economic environment as a
result. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also impair
our business operations.

Summary of Principal Risks Related to Our Business

● We  are  substantially  dependent  on  the  success  of  our  lead  product  candidate,  tenapanor,  which  may  not  receive
regulatory  approval  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis  or,  if  approved,  may  not  be
successfully commercialized for such indication. 

● Even if we are successful in obtaining regulatory approval for tenapanor for the control of serum phosphorus, and
tenapanor  is  ultimately  commercialized  for  any  approved  indications,  tenapanor  may  never  achieve  market
acceptance,  sufficient  third-party  coverage  or  reimbursement,  or  commercial  success,  which  will  depend,  in  part,
upon  the  degree  of  acceptance  among  physicians,  patients,  patient  advocacy  groups,  health  care  payors  and  the
medical community. Additionally, if the number of patients in the market for tenapanor or the price that the market
can bear is not as significant as we estimate, or if we are not able to secure adequate coverage and reimbursement for
tenapanor, we may not generate sufficient revenue from sales of tenapanor for the control of serum phosphorus.

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● Third-party payor coverage and reimbursement status of newly-approved products are uncertain. Failure to obtain or
maintain  adequate  coverage  and  reimbursement  for  tenapanor,  if  approved,  could  limit  our  ability  to  market
tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis  and  decrease  our  ability  to  generate
revenue.  For  example,  certain  policies  of  the  Biden  administration  with  respect  to  drug  pricing  or  reimbursement
may impact our business and industry. While there is significant uncertainty related to the insurance coverage and
reimbursement of newly approved products in general in the United States, there is additional uncertainty related to
insurance  coverage  and  reimbursement  for  drugs,  like  tenapanor,  which,  if  approved,  will  be  marketed  for  the
control of serum phosphorus in CKD patients on dialysis. If we are successful in obtaining regulatory approval to
market  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis,  our  ability  to  generate  and
sustain  future  revenues  from  sales  of  tenapanor  for  such  indication,  may  be  dependent  upon  whether  and  when
tenapanor, along with other oral end-stage renal disease (“ESRD”) related drugs without an injectable or intravenous
equivalent , are bundled into the ESRD prospective payment system, and the manner in which such introduction into
the ESRD prospective payment system may occur.

● We have not fully established our sales organization. If we are unable to establish sales capabilities on our own or

through third parties, we may not be able to commercialize tenapanor or any of our other product candidates.

● We rely completely on third parties to manufacture tenapanor and our other product candidates. If they are unable to
comply  with  applicable  regulatory  requirements,  unable  to  source  sufficient  raw  materials,  experience
manufacturing  or  distribution  difficulties  or  are  otherwise  unable  to  manufacture  sufficient  quantities  to  meet
demand, our commercialization of tenapanor, if approved, and our development efforts for tenapanor, RDX013 and
our other product candidates may be materially harmed.  

● We have a limited operating history, have incurred significant losses since our inception and will incur losses in the

future, which makes it difficult for us to assess our future viability.

● We have never generated any revenue from product sales and may never be profitable. Our ability to generate future
revenue from product sales or pursuant to milestone payments is dependent upon many factors, including, but not
limited to, obtaining regulatory approvals for tenapanor for the control of serum phosphorus, and establishing and
maintaining supply and manufacturing relationships with third parties that can provide adequate supply of product to
support the market demand for tenapanor; and obtaining market acceptance of tenapanor as a viable treatment option
for the indications for which it is approved and commercialized.

● We  will  require  substantial  additional  financing  to  achieve  our  goals,  and  the  inability  to  access  this  necessary
capital  when  needed  on  acceptable  terms,  or  at  all,  could  force  us  to  delay,  limit,  reduce  or  terminate  our  pre-
commercialization efforts for tenapanor and our other product development and platform development activities

● We may not be successful in our efforts to develop RDX013 or expand our pipeline of product candidates, as a result
of numerous factors, which may include the inability to access capital necessary to fund such efforts on acceptable
terms.

● We face an inherent risk of product liability as a result of the clinical testing of our product candidates and will face
an  even  greater  risk  if  we  commercialize  any  products.  For  example,  we  may  be  sued  if  any  product  we  develop
allegedly causes injury or is found to be otherwise unsuitable during product testing, manufacturing, marketing or
sale.  Any  such  product  liability  claims  may  include  allegations  of  defects  in  manufacturing,  defects  in  design,  a
failure  to  warn  of  dangers  inherent  in  the  product,  negligence,  strict  liability,  and  a  breach  of  warranties.  Claims
could  also  be  asserted  under  state  consumer  protection  acts.  If  we  cannot  successfully  defend  ourselves  against
product liability claims, we may incur substantial liabilities or be required to limit commercialization of our product
candidates. Even successful defense would require significant financial and management resources.

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● The COVID-19 pandemic continues to rapidly evolve. The extent to which the pandemic may impact our business,
manufacturing,  preclinical  development  activities,  preclinical  studies  and  planned  and  ongoing  clinical  trials  will
depend on future developments, which are highly uncertain and cannot be predicted with confidence, such as, the
duration of the pandemic, travel restrictions and actions to contain the pandemic or treat its impact, such as social
distancing,  quarantines  or  lock-downs  in  the  United  States  and  other  countries,  business  closures  or  business
disruptions and the effectiveness of actions taken in the United States and other countries to contain and treat the
disease. Specifically, while our Phase 3 clinical development of tenapanor for the control of serum phosphorus in
CKD patients on dialysis is complete, we have ongoing and planned clinical trials for tenapanor that may be delayed
as a result of the restrictions placed on access to dialysis centers during the COVID-19 pandemic. Other potential
impacts of the COVID-19 pandemic on our various clinical trials, including our ongoing Phase 2 clinical trial for
RDX013,  include  delays  or  difficulties  in  any  planned  clinical  site  initiation,  including  difficulties  in  obtaining
Institutional Review Board approvals, recruiting clinical site investigators and clinical site staff, delays or difficulties
in enrolling patients, interruption of planned key clinical trial activities, such as clinical trial site data monitoring due
to diversion of resources at clinical sites or limitation on travel imposed by federal or state governments.

● Our  operating  activities  may  be  restricted  as  a  result  of  covenants  related  to  the  indebtedness  under  our  loan  and
security  agreement  and  we  may  be  required  to  repay  the  outstanding  indebtedness  in  an  event  of  default,  which
could have a materially adverse effect on our business.

● Our products or product candidates may cause undesirable side effects or have other properties that could delay our
clinical trials, or delay or prevent regulatory approval, limit the commercial profile of an approved label, or result in
significant  negative  consequences  following  any  regulatory  approval  that  is  achieved.  If  we  or  others  identify
undesirable side effects caused by any product candidate following receipt of marketing approval, the ability for us
or  a  collaboration  partner  to  achieve  or  maintain  market  acceptance  of  the  approved  product  could  be  materially
affected and could result in the loss of significant revenue to us, which would materially and adversely affect our
results of operations and business.

● The regulatory approval processes of the FDA and comparable foreign authorities are lengthy, time consuming and
inherently unpredictable. If we are ultimately unable to obtain regulatory approval for our product candidates, our
business will be substantially harmed. Even if we receive regulatory approval for a product candidate, we will be
subject to ongoing regulatory obligations and continued regulatory review, which may result in significant additional
expense. Additionally, any product candidates, if approved, could be subject to labeling and other restrictions and
market  withdrawal,  and  we  may  be  subject  to  penalties  if  we  fail  to  comply  with  regulatory  requirements  or
experience unanticipated problems with our products.

Principal Risks Related to Our Business

We  are  substantially  dependent  on  the  success  of  our  lead  product  candidate,  tenapanor,  which  may  not  receive
regulatory approval for the control of serum phosphorus or be successfully commercialized for hyperphosphatemia or
IBS-C.

To date, we have invested a significant amount of our efforts and financial resources in the research and development
of tenapanor, which is currently our lead product candidate. The commercial success of tenapanor will depend on a number
of factors, including the following:

● whether  tenapanor’s  safety  and  efficacy  profile  is  satisfactory  to  the  FDA  and  foreign  regulatory  authorities  to

gain marketing approval for the control of serum phosphorus;

● the  ability  of  the  third-party  manufacturers  we  contract  with  to  provide  an  adequate  (in  amount  and  quality)
supply  of  product  to  support  the  market  demand  for  tenapanor  for  the  treatment  of  IBS-C,  and/or  if  approved,
tenapanor

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for the control of serum phosphorus in adult CKD patients on dialysis, particularly in light of the effects of the
COVID-19 pandemic;

● whether or not the content of the label approved by the FDA or foreign regulatory authorities may materially and
adversely  impact  our  ability  the  ability  of  our  collaboration  partners  to  commercialize  the  product  for  the
approved indication, or for any other indication;

● whether  we  will  be  required  to  conduct  clinical  trials  in  addition  to  those  anticipated  to  obtain  adequate

commercial pricing;

● the prevalence and severity of adverse side effects of tenapanor;

● the timely receipt of necessary marketing approvals from the FDA and foreign regulatory authorities;

● our ability, either alone, or with a collaboration partner, to successfully commercialize tenapanor, if approved for
marketing  and  sale  by  the  FDA  or  foreign  regulatory  authorities,  including  educating  physicians  and  patients
about the benefits, administration and use of tenapanor;

● achieving and maintaining compliance with all regulatory requirements applicable to tenapanor;

● acceptance of tenapanor as safe, effective and well-tolerated by patients and the medical community;

● our ability, alone or with collaboration partners, to manage the complex pricing and reimbursement negotiations
associated  with  marketing  the  same  product  at  different  doses  for  separate  indications  for  tenapanor  for  the
treatment of IBS-C, and, if approved, for the control of serum phosphorus in CKD patients on dialysis;

● the availability, perceived advantages, relative cost, relative safety and relative efficacy of tenapanor compared to

alternative and competing treatments;

● obtaining and sustaining an adequate level of coverage and reimbursement for tenapanor by third-party payors;

● enforcing intellectual property rights in and to tenapanor;

● avoiding third-party interference, opposition, derivation or similar proceedings with respect to our patent rights,

and avoiding other challenges to our patent rights and patent infringement claims; and

● a continued acceptable safety and tolerability profile of tenapanor following approval.

● As tenapanor is a first-in-class drug, there is a higher likelihood that approval may not be attained as compared to
a class of drugs with approved products. Although tenapanor met the primary endpoints in all of the three Phase 3
clinical trials evaluating tenapanor for the control of serum phosphorus in CKD patients on dialysis, there can be
no assurances that we will receive regulatory approval to market tenapanor for the control of serum phosphorus in
CKD patients on dialysis. Further, it may not be possible or practicable to demonstrate, or if approved, to market
tenapanor on the basis of certain of the benefits we believe tenapanor possesses. If the number of patients in the
market for tenapanor or the price that the market can bear is not as significant as we estimate, or if we are not able
to secure adequate coverage and reimbursement for tenapanor, we may not generate sufficient revenue from sales
of tenapanor for the control of serum phosphorus, if approved, or for IBS-C if commercialized. There can be no
assurance  that  tenapanor  will  ever  be  successfully  commercialized  or  that  we  will  ever  generate  income  from
sales  of  tenapanor.  If  we  are  not  successful  in  obtaining  approval  for  tenapanor  for  the  control  of  serum
phosphorus, or we are not successful in commercializing tenapanor, or are significantly delayed in doing so, our
business will be materially harmed.

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Even  if  we  are  successful  in  obtaining  regulatory  approval  for  tenapanor  for  the  control  of  serum  phosphorus,  and
tenapanor is ultimately commercialized for any approved indications, tenapanor may never achieve market acceptance,
sufficient third-party coverage or reimbursement, or commercial success, which will depend, in part, upon the degree of
acceptance among physicians, patients, patient advocacy groups, health care payors and the medical community.

Market  acceptance  of  tenapanor  for  IBS-C  and,  in  the  event  that  marketing  approval  is  obtained,  for  the  control  of

serum phosphorus, depends on a number of factors, including:

● the efficacy demonstrated in our clinical trials;

● with  respect  to  tenapanor  for  the  control  of  serum  phosphorus,  whether  tenapanor,  along  with  other  oral  only
medications, are included in the bundled prospective payment system for the treatment of ESRD patients, and the
time and manner in which such transition is achieved;

● the prevalence and severity of any side effects and overall safety and tolerability profile of the product;

● the clinical indications for which it is approved;

● advantages over new or traditional or existing therapies, including recently approved therapies or therapies that

the physician community anticipate will be approved;

● acceptance  by  physicians,  major  operators  of  clinics  and  patients  of  tenapanor  as  a  safe,  effective  and  well-

tolerated treatment;

● relative convenience and ease of administration of tenapanor;

● the  potential  and  perceived  advantages  of  tenapanor  over  current  treatment  options  or  alternative  treatments,

including future alternative treatments;

● the cost of treatment in relation to alternative treatments and the willingness to pay for tenapanor, if approved, on

the part of physicians and patients;

● the availability of alternative products and their ability to meet market demand; and

● the quality of our relationships with patient advocacy groups.

● Any  failure  of  tenapanor  to  achieve  market  acceptance,  sufficient  third-party  coverage  or  reimbursement,  or

commercial success for any approved indications would adversely affect our results of operations.

We  do  not  have  a  fully  established  sales  organization.  If  we  are  unable  to  establish  sales  capabilities  on  our  own  or
through third parties, we may not be able to commercialize tenapanor or any of our other product candidates.

We  currently  plan  to  commercialize  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis,  if
approved, on our own. In order to do so, we will need to complete the establishment of an appropriate sales organization
with  technical  expertise,  as  well  as  supporting  distribution  capabilities.  This  will  continue  to  be  expensive  and  time
consuming. As a company, we have no prior experience in the marketing, sale and distribution of pharmaceutical products
and there are significant risks involved in building and managing a sales organization, including our ability to secure the
capital  necessary  to  fund  such  efforts  on  acceptable  terms,  hire,  retain,  and  incentivize  qualified  individuals,  generate
sufficient  sales  leads,  provide  adequate  training  to  sales  and  marketing  personnel,  comply  with  regulatory  requirements
applicable  to  the  marketing  and  sale  of  drug  products  and  effectively  manage  a  geographically  dispersed  sales  and
marketing team.

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If we fail or are delayed in the development of our internal sales, marketing and distribution capabilities, we may need
to  delay  the  commercialization  tenapanor  for  the  control  of  serum  phosphorus,  if  approved,  or  such  commercialization
could be adversely impacted.

Third-party payor coverage and reimbursement status of newly-approved products are uncertain. Failure to obtain or
maintain adequate coverage and reimbursement for our products, if approved, could limit our ability to market those
products and decrease our ability to generate revenue.

The  pricing,  coverage  and  reimbursement  of  our  product  candidates,  if  approved,  must  be  adequate  to  support  a
commercial  infrastructure.  The  availability  and  adequacy  of  coverage  and  reimbursement  by  governmental  and  private
payors are essential for most patients to be able to afford treatments such as ours, assuming approval. Sales of our product
candidates  will  depend  substantially,  both  domestically  and  abroad,  on  the  extent  to  which  the  costs  of  our  product
candidates will be paid for by health maintenance, managed care, pharmacy benefit, and similar healthcare management
organizations, or reimbursed by government authorities, private health insurers, and other third-party payors. If coverage
and reimbursement are not available, or are available only to limited levels, we, or our collaboration partners, may not be
able  to  successfully  commercialize  our  product  candidates.  Even  if  coverage  is  provided,  the  approved  reimbursement
amount may not be high enough to allow us to establish or maintain pricing sufficient to realize a return on our investment.

There is significant uncertainty related to the insurance coverage and reimbursement of newly approved products. In
the  United  States,  the  principal  decisions  about  coverage  and  reimbursement  for  new  drugs  are  typically  made  by  the
Centers for Medicare & Medicaid Services (“CMS”), an agency within the United States Department of Health and Human
Services responsible for administering the Medicare program, as CMS decides whether and to what extent a new drug will
be covered and reimbursed under Medicare. Private payors tend to follow the coverage reimbursement policies established
by CMS to a substantial degree. It is difficult to predict what CMS will decide with respect to reimbursement for products
such as ours.

There  is  increased  uncertainty  related  to  insurance  coverage  and  reimbursement  for  drugs,  like  tenapanor,  which,  if
approved,  will  be  marketed  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis.  In  January  2011,  CMS
implemented  a  new  prospective  payment  system  for  dialysis  treatment.  Under  the  ESRD  prospective  payment  system,
CMS generally makes a single bundled payment to the dialysis facility for each dialysis treatment that covers all items and
services routinely required for dialysis treatments furnished to Medicare beneficiaries in Medicare-certified ESRD facilities
or  at  their  home,  including  the  cost  of  certain  routine  drugs.  The  inclusion  of  oral  medications  without  injectable  or
intravenous equivalents in the bundled payment was initially delayed until January 1, 2014 and through several subsequent
legislative  actions  was  delayed  until  January  1,  2025.  As  a  result,  absent  further  legislation  or  regulation  on  this  matter,
beginning in 2025, oral ESRD-related drugs without injectable or intravenous equivalents may be included in the ESRD
bundle  and  separate  Medicare  payment  for  these  drugs  will  no  longer  be  available,  as  is  the  case  today  under  Medicare
Part  D.  While  it  is  too  early  to  project  the  full  impact  that  bundling  may  have  on  tenapanor  and  our  business  should
tenapanor be brought into the bundle in 2025, or at any time,  we may be unable to sell tenapanor, if approved, to dialysis
providers on a profitable basis if third-party payors reduce their current levels of payment, or if our costs of production are
higher than levels necessary for an appropriate gross margin after payment of all discounts, rebates and  chargebacks.

Outside the United States, international operations are generally subject to extensive governmental price controls and
other market regulations, and we believe the increasing emphasis on cost-containment initiatives in Europe, Canada, Japan,
China and other countries has and will continue to put pressure on the pricing and usage of our product candidates. In many
countries, the prices of medical products are subject to varying price control mechanisms as part of national health systems.
Other countries allow companies to fix their own prices for medicinal products, but monitor and control company profits.
Additional foreign price controls or other changes in pricing regulation could restrict the amount that we are able to charge
for our product candidates. Accordingly, in markets outside the United States, the reimbursement for our products may be
reduced compared with the United States and may be insufficient to generate commercially reasonable revenue and profits.

Moreover, increasing efforts by governmental and third-party payors in the United States and abroad to cap or reduce

healthcare costs may cause such organizations to limit both coverage and the level of reimbursement for newly approved

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products and, as a result, these caps may not cover or provide adequate payment for our product candidates. We expect to
experience pricing pressures in connection with the sale of any of our product candidates due to the trend toward managed
healthcare, the increasing influence of health maintenance organizations, and additional legislative changes. The downward
pressure on healthcare costs in general, particularly prescription drugs and surgical procedures and other treatments, has
become very intense. As a result, increasingly high barriers are being erected to the entry of new products.

We rely completely on third parties to manufacture tenapanor and our other product candidates. If they are unable to
comply with applicable regulatory requirements, unable to source sufficient raw materials, experience manufacturing
or  distribution  difficulties  or  are  otherwise  unable  to  manufacture  sufficient  quantities  to  meet  demand,  our
commercialization  of  tenapanor,  if  approved,  and  our  development  efforts  for  tenapanor,  RDX013  and  our  other
product candidates may be materially harmed.

We  do  not  currently  have,  nor  do  we  plan  to  acquire,  the  infrastructure  or  capability  internally  to  manufacture
tenapanor or any of other our product candidates on a commercial scale, or to manufacture our drug supplies for use in the
conduct of our nonclinical and clinical studies. The facilities used by our contract manufacturers to manufacture our drug
supply are subject to inspection by the FDA. Our  ability to control the manufacturing process of our product candidates is
limited  to  the  contractual  requirements  and  obligations  we  impose  on  our  contract  manufacturer.  Although  they  are
contractually required to so do, we are completely dependent on our contract manufacturing partners for compliance with
the regulatory requirements, known as current Good Manufacturing Practice requirements (“cGMPs”), for manufacture of
both active drug substances and finished drug products.

The  manufacture  of  pharmaceutical  products  requires  significant  expertise  and  capital  investment.  Manufacturers  of
pharmaceutical  products  often  encounter  difficulties  in  commercial  production.  These  problems  may  include  difficulties
with  production  costs  and  yields,  quality  control,  including  stability  of  the  product  and  quality  assurance  testing,  and
shortages  of  qualified  personnel,  as  well  as  compliance  with  federal,  state  and  foreign  regulations  and  the  challenges
associated with complex supply chain management. Even if our contract manufacturers do not experience problems and
commercial manufacturing is achieved, their maximum or available manufacturing capacities may be insufficient to meet
commercial demand. Finding alternative manufacturers or adding additional manufacturers requires a significant amount of
time and involves significant expense. New manufacturers would need to develop and implement the necessary production
techniques  and  processes,  which  along  with  their  facilities,  would  need  to  be  inspected  and  approved  by  the  regulatory
authorities in each applicable territory. In addition, the raw materials necessary to make API for our products are acquired
from  a  limited  number  of  sources.  Any  delay  or  disruption  in  the  availability  of  these  raw  materials  could  result  in
production disruptions, delays or higher costs with consequent adverse effects on us.

If our contract manufacturers fail to adhere to applicable GMP or other regulatory requirements, experience delays or
disruptions  in  the  availability  of  raw  materials  or  experience  manufacturing  or  distribution  problems,  we  may  suffer
significant consequences, including the inability to meet our product requirements for our clinical development programs,
and if tenapanor is approved for marketing for the control of serum phosphorus in CKD patients on dialysis, such events
could  result  in  product  seizures  or  recalls,  loss  of  product  approval,  fines  and  sanctions,  reputational  damage,  shipment
delays, inventory shortages, inventory write-offs and other product-related charges and increased manufacturing costs. As a
result,  or  if  maximum  or  available  manufacturing  capacities  are  insufficient  to  meet  demand,  our  development  or  our
commercialization efforts for tenapanor for the control of serum phosphorus, if approved, may be materially harmed.

Risks Related to our Financial Condition and Capital Requirements

We have a limited operating history, have incurred significant losses since our inception and we will incur losses in the
future, which makes it difficult to assess our future viability.

We  are  a  clinical-stage  biopharmaceutical  company  with  a  limited  operating  history.  Biopharmaceutical  product
development  is  a  highly  speculative  undertaking  and  involves  a  substantial  degree  of  risk.  To  date,  we  have  focused
substantially all of our efforts on our research and development activities, including developing tenapanor and developing
our proprietary drug discovery and design platform. To date, we have not commercialized any products or generated any
revenue from the sale of products.

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We are not profitable and have incurred losses in each year since our inception in October 2007, and we do not know
whether  or  when  we  will  become  profitable.  We  continue  to  incur  significant  research,  development  and  other  expenses
related to our ongoing operations. As of December 31, 2020, we had an accumulated deficit of $554.8 million.

We expect to continue to incur substantial operating losses for the foreseeable future as we prepare for the potential
commercialization of, and incur manufacturing and development costs for, tenapanor for the control of serum phosphorus
in CKD patients on dialysis; as we commence commercialization of tenapanor for that indication, if approved; as we incur
development costs for RDX013; and as we continue our discovery and research activities.

Our prior losses, combined with expected future losses, have had and will continue to have an adverse effect on our
stockholders’  equity  and  working  capital.  Further,  the  net  losses  we  incur  may  fluctuate  significantly  from  quarter-to-
quarter and year-to-year, such that a period-to-period comparison of our results of operations may not be a good indication
of our future performance.

We have substantial net operating loss and tax credit carryforwards for Federal and California income tax purposes.
Such net operating losses and tax credits carryforwards may be reduced as a result of certain intercompany restructuring
transactions. In addition, the future utilization of such net operating loss and tax credit carryforwards and credits will be
subject to limitations, pursuant to Internal Revenue Code Sections 382 and 383, as a result of ownership changes that have
occurred previously and additional limitations may be applicable as a result of ownership changes that could occur in the
future.

We have never generated any revenue from product sales and may never be profitable.

We received FDA approval for our New Drug Application (“NDA”) for tenapanor for the treatment of IBS-C in adults
in September 2019. However, we have not commercialized tenapanor for IBS-C ourselves in the United States and have
not entered into a collaboration partnership for such commercialization. We have no other products approved for sale and
have  never  generated  any  revenue  from  product  sales.  Our  ability  to  generate  revenue  from  product  sales  and  achieve
profitability  depends  on  our  ability  to  obtain  approval  of  the  United  States  Food  and  Drug  Administration  (“FDA”)  to
commercialize tenapanor for the control of serum phosphorus in CKD patients on dialysis in the U.S. and the ability of our
collaboration  partners  to  obtain  regulatory  approval  to  market  tenapanor  in  their  respective  territories.  There  can  be  no
assurances  that  we  will  generate  product  revenue  from  sales  of  tenapanor,  either  on  our  own,  or  with  a  collaboration
partner. Our ability to generate future revenue from product sales or pursuant to milestone payments depends heavily on
many factors, including but not limited to:

● obtaining  regulatory  approvals  for  tenapanor  for  the  control  of  serum  phosphorus  in  adult  CKD  patients  on

dialysis, either on our own or with one or more collaboration partners;

● our ability to successfully commercialize tenapanor, which has been approved by the FDA for the treatment of
IBS-C  in  adults,  and/or  tenapanor  for  the  control  of  serum  phosphorus  in  adult  CKD  patients  on  dialysis,  if
approved, either on our own or with one or more collaboration partners;

● establishing  and  maintaining  supply  and  manufacturing  relationships  with  third  parties  that  can  provide  an
adequate (in amount and quality) supply of product to support the market demand for tenapanor for the treatment
of IBS-C, and/or, if approved, tenapanor for the control of serum phosphorus in adult CKD patients on dialysis;

● obtaining market acceptance of tenapanor as a viable treatment option for the indications for which it is approved

and commercialized;

● addressing any competing technological and market developments;

● maintaining,  protecting  and  expanding  our  portfolio  of  intellectual  property  rights,  including  patents,  trade
secrets, and know-how, and our ability to develop, manufacture and commercialize our product candidates and
products without infringing intellectual property rights of others; and

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● attracting, hiring, and retaining qualified personnel.

In cases where we are successful in obtaining regulatory approvals to market tenapanor for one or more indications,
our  revenue  will  be  dependent,  in  part,  upon  the  size  of  the  markets  in  the  territories  for  which  regulatory  approval  is
granted,  the  accepted  price  for  the  product,  the  ability  to  get  reimbursement  at  any  price  and  whether  we  are
commercializing the product or the product is being commercialized by a collaboration partner, and in such case, whether
we have royalty and/or co-promotion rights for that territory, and whether any royalty we have a right to receive from a
collaboration  partner  is  in  excess  of  the  royalty  we  owe  AstraZeneca  as  a  result  of  the  termination  of  our  License
Agreement with AstraZeneca in 2015. See Note 12, Collaboration and Licensing Agreements, in the notes to our financial
statements, included in Part II, Item 8, for details on our obligations to AstraZeneca. While there is significant uncertainty
related to the insurance coverage and reimbursement of newly approved products in general in the United States, there is
additional uncertainty related to insurance coverage and reimbursement for drugs, like tenapanor, which, if approved, will
be marketed for the control of serum phosphorus in CKD patients on dialysis. If we are successful in obtaining regulatory
approval to market tenapanor for the control of serum phosphorus in CKD patients on dialysis, our ability to generate and
sustain future revenues from sales of tenapanor for such indication, may be dependent upon whether and when tenapanor,
along with other oral end-stage renal disease (“ESRD”) related drugs without an injectable or intravenous equivalent, are
bundled into the ESRD prospective payment system, and the manner in which such introduction into the ESRD prospective
payment  system  may  occur.  See  “Third-party  payor  coverage  and  reimbursement  status  of  newly-approved  products  is
uncertain. Failure to obtain or maintain adequate coverage and reimbursement for our products, if approved, could limit
our ability to market those products and decrease our ability to generate revenue” below. Additionally, if the number of
patients  suitable  for  tenapanor  is  not  as  significant  as  we  estimate,  the  indication  approved  by  regulatory  authorities  is
narrower  than  we  expect,  coverage  and  reimbursement  for  tenapanor  are  not  available  in  the  manner  and  to  the  extent
which  we  expect,  or  the  reasonably  accepted  population  for  treatment  is  narrowed  by  competition,  physician  choice  or
treatment  guidelines,  we  may  not  generate  significant  revenue  from  the  sale  of  tenapanor,  even  if  approved.  Even  if  we
achieve profitability in the future, we may not be able to sustain profitability in subsequent periods. Our failure to generate
revenue from product sales would likely depress our market value and could impair our ability to raise capital, expand our
business, discover or develop other product candidates or continue our operations. A decline in the value of our common
stock could cause our stockholders to lose all or part of their investment.

We will require substantial additional financing to achieve our goals, and the inability to access this necessary capital
when needed on acceptable terms, or at all, could force us to delay, limit, reduce or terminate our commercialization
efforts  for  tenapanor  for  the  control  of  serum  phosphorus,  if  approved,  and  our  other  product  development  and
platform development activities.

Since our inception, most of our resources have been dedicated to our research and development activities, including
developing our clinical product candidate tenapanor and developing our proprietary drug discovery and design platform.
We believe that we will continue to expend substantial resources for the foreseeable future, including, if approved, costs
associated  with  the  commercialization  of  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis,
research  and  development,  conducting  preclinical  studies  and  clinical  trials  for  our  other  programs,  including  RDX013,
obtaining regulatory approvals, scaling our manufacturing processes for our product candidates and sales and marketing.
Because  the  outcome  of  any  clinical  trial  and/or  regulatory  approval  process  is  highly  uncertain,  we  cannot  reasonably
estimate  the  actual  amounts  necessary  to  successfully  complete  the  development,  regulatory  approval  process  and
commercialization  or  co-promotion  of  any  of  our  product  candidates.  Our  future  funding  requirements  will  depend  on
many factors, including, but not limited to:

● the  FDA’s  actions  and  decisions  with  respect  to  the  NDA  submitted  to  the  FDA  on  June  30,  2020  to  request
marketing authorization for tenapanor for the control of serum phosphorus in adult CKD patients on dialysis;

● our  ability  to  successfully  commercialize  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on

dialysis, if approved, either alone or with one or more collaboration partners;

● the sales price and the availability of adequate third-party reimbursement for tenapanor, if approved;

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● the manufacturing costs of our product candidates, and the availability of one or more suppliers for our product

candidates at reasonable costs, both for clinical and commercial supply;

● the selling and marketing costs associated with tenapanor, including the cost and timing of building our sales and

marketing capabilities;

● our  ability  to  maintain  our  existing  collaboration  partnerships  and  to  establish  additional  collaboration
partnerships, in-license/out-license, joint ventures or other similar arrangements and the financial terms of such
agreements;

● the timing, receipt, and amount of sales of, or royalties on, tenapanor, if any;

● the cash requirements of any future acquisitions or discovery of product candidates;

● the number and scope of preclinical and discovery programs that we decide to pursue or initiate, and any clinical

trials we decide to pursue for other product candidates, including RDX013;

● the time and cost necessary to respond to technological and market developments;

● the  costs  of  filing,  prosecuting,  maintaining,  defending  and  enforcing  any  patent  claims  and  other  intellectual
property  rights,  including  litigation  costs  and  the  outcome  of  such  litigation,  including  costs  of  defending  any
claims of infringement brought by others in connection with the development, manufacture or commercialization
of tenapanor or any of our product candidates; and

● the payment of interest and principal related to our loan and security agreement entered into with Solar Capital

and Western Alliance Bank in May 2018, as amended in October 2020.

Additional funds may not be available when we need them on terms that are acceptable to us, or at all. If adequate
funds  are  not  available  to  us  on  a  timely  basis,  we  may  be  required  to  delay,  limit,  reduce  or  terminate  our  research
activities,  preclinical  and  clinical  trials  for  our  product  candidates  and  our  establishment  and  maintenance  of  sales  and
marketing  capabilities  or  other  activities  that  may  be  necessary  to  commercialize  tenapanor,  either  alone  or  with
collaboration partners. Additionally, our inability to access capital on a timely basis and on terms that are acceptable to us
may force us to restructure certain aspects of our business or identify and complete one or more strategic collaborations or
other transactions in order to fund the development or commercialization of tenapanor or certain of our product candidates
through the use of alternative structures.

Our  operating  activities  may  be  restricted  as  a  result  of  covenants  related  to  the  indebtedness  under  our  loan  and
security agreement and we may be required to repay the outstanding indebtedness in an event of default, which could
have a materially adverse effect on our business.

On May 16, 2018, we entered into a loan and security agreement with Solar Capital, Ltd. and Western Alliance Bank
(collectively the “Lenders”) pursuant to which the Lenders agreed to provide us a $50.0 million term loan facility with a
maturity  date  of  November  1,  2022.  On  October  9,  2020,  we  entered  into  an  amendment  to  the  loan  and  security
agreement. The full amount of the loan was funded on May 16, 2018. Until we have repaid such indebtedness, the loan and
security  agreement  subjects  us  to  various  customary  covenants,  including  requirements  as  to  financial  reporting  and
insurance and restrictions on our ability to dispose of our business or property, to change our line of business, to liquidate
or dissolve, to enter into any change in control transaction, to merge or consolidate with any other entity or to acquire all or
substantially  all  the  capital  stock  or  property  of  another  entity,  to  incur  additional  indebtedness,  to  incur  liens  on  our
property, to pay any dividends or other distributions on capital stock other than dividends payable solely in capital stock, to
redeem  capital  stock,  to  enter  into  licensing  agreements,  to  engage  in  transactions  with  affiliates,  and  to  encumber  our
intellectual property. Our business may be adversely affected by these restrictions on our ability to operate our business.

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We are permitted to make interest only payments on the loan facility through December 1, 2021, unless we have not
received FDA approval for our NDA for tenapanor for the control of serum phosphorus in CKD patients on dialysis on or
before  May  31,  2020,  or  the  FDA  issues  a  complete  response  letter  in  connection  with  such  NDA.  In  either  event,  the
period in which we are permitted to make interest only payments shall end on the earlier of June 1, 2021, or the first day of
the  month  following  the  date  that  the  FDA  issues  a  CRL.  However,  we  may  be  required  to  repay  the  outstanding
indebtedness under the loan facility if an event of default occurs under the loan and security agreement. An event of default
will occur if, among other things, we fail to make payments under the loan and security agreement; we breach any of our
covenants  under  the  loan  and  security  agreement,  subject  to  specified  cure  periods  with  respect  to  certain  breaches;  the
Lenders  determine  that  a  material  adverse  change  has  occurred;  we  or  our  assets  become  subject  to  certain  legal
proceedings,  such  as  bankruptcy  proceedings;  we  are  unable  to  pay  our  debts  as  they  become  due;  or  we  default  on
contracts with third parties which would permit the Lenders to accelerate the maturity of such indebtedness or that could
have a material adverse change on us. We may not have enough available cash or be able to raise additional funds through
equity or debt financings to repay such indebtedness at the time any such event of default occurs. In this case, we may be
required to delay, limit, reduce or terminate our product development or commercialization efforts or grant to others’ rights
to develop and market product candidates that we would otherwise prefer to develop and market ourselves. The Lenders
could also exercise their rights as collateral agent to take possession of and to dispose of the collateral securing the term
loans,  which  collateral  includes  substantially  all  of  our  property  (excluding  intellectual  property,  which  is  subject  to  a
negative  pledge).  Our  business,  financial  condition  and  results  of  operations  could  be  materially  adversely  affected  as  a
result of any of these events.

Additional Risks Related to Our Business and Industry

We may not be successful in our efforts to develop RDX013 or any other product candidates that are at an early stage of
development,  or  expand  our  pipeline  of  product  candidates,  as  a  result  of  numerous  factors,  which  may  include  the
inability to access capital necessary to fund such efforts on acceptable terms.

A key element of our strategy has been focused on the expansion of our pipeline of product candidates utilizing our
proprietary drug discovery and design platform and to advance such product candidates through clinical development. Our
inability to access capital in a timely manner or on acceptable terms to fund our early stage product candidates may force
us  to  consider  certain  restructuring  activities  to  enable  the  funding  of  those  early  assets  through  the  use  of  alternative
structures. In addition, of the large number of drugs in development, only a small percentage of such drugs successfully
complete  the  FDA  regulatory  approval  process  and  are  commercialized.  Accordingly,  even  if  we  are  able  to  continue  to
fund our research and early-stage development programs, there can be no assurance that any product candidates will reach
the clinic or be successfully developed or commercialized.

Research  programs  to  identify  product  candidates  require  substantial  technical,  financial  and  human  resources,
whether  or  not  any  product  candidates  are  ultimately  identified.  Although  our  research  and  development  efforts  to  date
have resulted in several development programs, we may not be able to develop product candidates that are safe, effective
and well-tolerated. Our research programs may initially show promise in identifying potential product candidates, and we
may select candidates for development, yet we may fail to advance product candidates to clinical development for many
reasons, including the following:

● we may be unable to access sufficient capital on acceptable terms to fund the development of all of our assets and
as a result we may be forced to delay or terminate the development of certain product candidates, or to consider
restructuring efforts to secure alternate funding for those assets;

● the research methodology used and our drug discovery and design platform may not be successful in identifying

potential product candidates;

● competitors may develop alternatives that render our product candidates obsolete or less attractive;

● product candidates we develop may nevertheless be covered by third parties’ patents or other exclusive rights;

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● the  market  for  a  product  candidate  may  change  during  our  program  so  that  the  continued  development  of  that

product candidate is no longer reasonable;

● a  product  candidate  may  on  further  study  be  shown  to  have  harmful  side  effects  or  other  characteristics  that
indicate  it  is  unlikely  to  be  effective,  well-tolerated  or  otherwise  does  not  meet  applicable  regulatory  or
commercial criteria;

● a product candidate may not be capable of being produced in commercial quantities at an acceptable cost, or at

all; and

● a product candidate may not be accepted as safe, effective and well-tolerated by patients, the medical community

or third-party payors, if applicable.

Even if we are successful in continuing to expand our pipeline, through our own research and development efforts, the
potential product candidates that we identify or for which we acquire rights may not be suitable for clinical development,
including as a result of being shown to have harmful side effects or other characteristics that indicate that they are unlikely
to  receive  marketing  approval  and  achieve  market  acceptance.  If  we  do  not  successfully  develop  and  commercialize  a
product pipeline, we may not be able to generate revenue from product sales in future periods or ever achieve profitability.

Clinical  drug  development  involves  a  lengthy  and  expensive  process  with  an  uncertain  outcome  and  the  results  of
earlier studies and trials may not be predictive of future trial results.

Before  obtaining  marketing  approval  from  regulatory  authorities  for  the  sale  of  our  product  candidates,  we  must
conduct  extensive  clinical  studies  to  demonstrate  the  safety  and  efficacy  of  the  product  candidates  in  humans.  Clinical
testing is expensive and can take many years to complete, and its outcome is inherently uncertain. Failure can occur at any
time  during  the  clinical  trial  process.  The  results  of  preclinical  and  clinical  studies  of  our  product  candidates,  including
RDX013,  may  not  be  predictive  of  the  results  of  later-stage  clinical  trials.  An  unexpected  adverse  event  profile,  or  the
results  of  drug-drug  interaction  studies,  may  present  challenges  for  the  future  development  and  commercialization  of  a
product  candidate  for  a  particular  condition  despite  receipt  of  positive  efficacy  data  in  a  clinical  study.  A  number  of
companies  in  the  pharmaceutical,  biopharmaceutical  and  biotechnology  industries  have  suffered  significant  setbacks  in
advanced  clinical  trials  for  similar  indications  that  we  are  pursuing  due  to  lack  of  efficacy  or  adverse  safety  profiles,
notwithstanding promising results in earlier studies, and we cannot be certain that we will not face similar setbacks.

Our ongoing RDX013 Phase 2 clinical trial or any of our other ongoing clinical trials may be impacted by the COVID-
19  pandemic  in  a  number  of  ways,  including  delays  or  difficulties  in  any  planned  clinical  site  initiation,  difficulties  in
obtaining  IRB  approvals,  recruiting  clinical  site  investigators  and  clinical  site  staff,  delays  or  difficulties  in  enrolling
patients, interruption of planned key clinical trial activities, such as clinical trial site data monitoring due to diversion of
resources at clinical sites or limitation on travel imposed by federal or state governments.

Furthermore,  we  could  encounter  delays  if  our  ongoing  RDX013  Phase  2  clinical  trial,  or  any  other  of  our  clinical
trials are suspended or terminated by us, by the IRBs of the institutions in which the trial is being conducted, or by the
FDA or other regulatory authorities. Such authorities may suspend or terminate a clinical trial due to a number of factors,
including  failure  to  conduct  the  clinical  trial  in  accordance  with  regulatory  requirements  or  our  clinical  protocols,
inspection of the clinical trial operations or trial site by the FDA or other regulatory authorities resulting in the imposition
of  a  clinical  hold,  unforeseen  safety  issues  or  adverse  side  effects,  failure  to  demonstrate  a  benefit  from  using  a  drug,
changes in governmental regulations or administrative actions or lack of adequate funding to continue the clinical trial.

In addition, identifying and qualifying patients to participate in our RDX013 Phase 2 clinical trial or any of our other
clinical  trials  is  critical  to  our  success.  The  timing  of  our  clinical  trials  depends,  in  part,  on  the  speed  at  which  we  can
recruit  patients  to  participate  in  testing  our  product  candidates.  Patients  may  be  unwilling  to  participate  in  our  clinical
studies because of concerns about adverse events observed with the current standard of care, competitor products and/or
other investigational agents, in each case for the same indications and/or similar patient populations. In addition, patients

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currently receiving treatment with the current standard of care or a competitor product may be reluctant to participate in a
clinical  trial  with  an  investigational  drug,  or  our  inclusion  and  exclusion  criteria  for  our  clinical  trials  may  present
challenges in identifying acceptable patients. As a result, the timeline for recruiting patients and conducting our RDX013
Phase 2 clinical trial or any of our other clinical trials may be delayed. These delays could result in increased costs, delays
in  advancing  our  development  of  our  product  candidates,  or  termination  of  the  clinical  studies  altogether.  Any  of  these
occurrences may significantly harm our business, financial condition and prospects.

Furthermore, even though we have completed our Phase 3 clinical development program for tenapanor for the control
of serum phosphorus, the results may not be sufficient to obtain the desired regulatory approval for tenapanor, or if such
regulatory approval is obtained, the content of the label approved by regulatory authorities may materially and adversely
impact our ability to commercialize the product for the approved indication.

We rely on third parties to conduct some of our nonclinical studies and all of our clinical trials. If these third parties do
not successfully carry out their contractual duties or meet expected deadlines, we may be unable to obtain regulatory
approval for additional products or commercialize our product candidates.

We do not have the ability to independently conduct clinical trials and, in some cases, nonclinical studies. We rely on
medical institutions, clinical investigators, contract laboratories, and other third parties, such as CROs, to conduct clinical
trials  on  our  product  candidates.  The  third  parties  with  whom  we  contract  for  execution  of  the  clinical  trials  play  a
significant  role  in  the  conduct  of  these  trials  and  the  subsequent  collection  and  analysis  of  data.  However,  these  third
parties are not our employees, and except for contractual duties and obligations, we control only certain aspects of their
activities and have limited ability to control the amount or timing of resources that they devote to our programs. Although
we rely, and will continue to rely, on these third parties to conduct some of our nonclinical studies and all of our clinical
trials, we remain responsible for ensuring that each of our studies and clinical trials is conducted in accordance with the
applicable protocol, legal, regulatory and scientific standards and our reliance on third parties does not relieve us of our
regulatory responsibilities. We, and these third parties are required to comply with current GLPs for nonclinical studies,
and good clinical practices (“GCPs”) for clinical studies. GLPs and GCPs are regulations and guidelines enforced by the
FDA, the Competent Authorities of the Member States of the European Economic Area (“EEA”) and comparable foreign
regulatory authorities for all of our products in nonclinical and clinical development, respectively. Regulatory authorities
enforce GCPs through periodic inspections of trial sponsors, principal investigators and trial sites. If we or any of our third-
party contractors fail to comply with applicable regulatory requirements, including GCPs, the clinical data generated in our
clinical trials may be deemed unreliable and the FDA, the European Medicines Agency (“EMA”), or comparable foreign
regulatory  authorities  may  require  us  to  perform  additional  clinical  trials  before  approving  our  marketing  applications.
There can be no assurance that upon inspection by a given regulatory authority, such regulatory authority will determine
that any of our clinical trials comply with GCP regulations. In addition, our clinical trials must be conducted with product
produced  under  cGMP  regulations.  Our  failure  to  comply  with  these  regulations  may  require  us  to  repeat  clinical  trials,
which would delay the regulatory approval process.

Our  products  or  product  candidates  may  cause  undesirable  side  effects  or  have  other  properties  that  could  delay  our
clinical trials, or delay or prevent regulatory approval, limit the commercial profile of an approved label, or result in
significant  negative  consequences  following  any  regulatory  approval  that  is  achieved.  If  we  or  others  identify
undesirable side effects caused by any product candidate following receipt of marketing approval, the ability to market
such product candidate could be compromised.

Undesirable  side  effects  caused  by  our  products  or  product  candidates  could  cause  us  or  regulatory  authorities  to
interrupt, delay or halt clinical trials, result in the delay or denial of regulatory approval by the FDA or other comparable
foreign regulatory authorities or limit the commercial profile of an approved label. To date, patients treated with tenapanor
have  experienced  drug-related  side  effects  including  diarrhea,  nausea,  vomiting,  flatulence,  abdominal  discomfort,
abdominal pain, abdominal distention and changes in electrolytes. Despite our receipt of marketing approval for tenapanor
for IBS-C in adults and the completion of our Phase 3 clinical program for tenapanor for the control of serum phosphorus,
in  the  event  that  future  trials  conducted  by  us  with  tenapanor,  or  trials  we  conduct  with  RDX013  or  our  other  product
candidates, reveal an unacceptable severity and prevalence of these or other side effects, such trials could be suspended or
terminated  and  the  FDA  or  comparable  foreign  regulatory  authorities  could  order  us  to  cease  further  development  of  or
deny approval of tenapanor, RDX013, or any such other product candidate, for any or all targeted indications. Additionally,

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despite  a  positive  efficacy  profile,  the  prevalence  and/or  severity  of  these  or  other  side  effects  could  cause  us  to  cease
further development of a product candidate for a particular indication, or entirely. The drug-related side effects could affect
patient recruitment or the ability of enrolled patients to complete the trial or result in potential product liability claims. Any
of these occurrences may harm our business, financial condition and prospects significantly.

In addition, if we or others identify undesirable side effects caused by one of our products for which we have received

regulatory approval, a number of potentially significant negative consequences could occur, including:

● regulatory authorities may withdraw their approval of the product or seize the product;

● we or a collaboration partner may be required to recall the product;

● additional restrictions may be imposed on the marketing of the particular product or the manufacturing processes
for the product or any component thereof, including the imposition of a Risk Evaluation and Mitigation Strategy
(“REMS”)  which  could  require  creation  of  a  Medication  Guide  or  patient  package  insert  outlining  the  risks  of
such side effects for distribution to patients, a communication plan to educate healthcare providers of the drugs’
risks,  as  well  as  other  elements  to  assure  safe  use  of  the  product,  such  as  a  patient  registry  and  training  and
certification of prescribers;

● we or a collaboration partner may be subject to fines, injunctions or the imposition of civil or criminal penalties;

● regulatory  authorities  may  require  the  addition  of  labeling  statements,  such  as  a  “black  box”  warning  or  a

contraindication;

● we could be sued and held liable for harm caused to patients;

● the product may become less competitive; and

● our reputation may suffer.

Any  of  the  foregoing  events  could  prevent  us,  or  a  collaboration  partner,  from  achieving  or  maintaining  market
acceptance of a particular product candidate, if approved, and could result in the loss of significant revenue to us, which
would materially and adversely affect our results of operations and business.

We face substantial competition and our competitors may discover, develop or commercialize products faster or more
successfully than us.

The  biotechnology  and  pharmaceutical  industries  are  highly  competitive,  and  we  face  significant  competition  from
companies  in  the  biotechnology,  pharmaceutical  and  other  related  markets  that  are  researching  and  marketing  products
designed to address diseases that we are currently developing products to treat. If approved for marketing by the FDA or
other regulatory agencies, tenapanor, as well as our other product candidates, would compete against existing treatments.

For example, tenapanor, if approved for the control of serum phosphorus in adult patients with CKD on dialysis, will
compete with phosphate binders used for the same indication`. The various types of phosphate binders commercialized in
the United States include the following:

● Calcium carbonate (many over-the-counter brands including Tums and Caltrate);

● Calcium acetate (several prescription brands including PhosLo and Phoslyra);

● Lanthanum carbonate (Fosrenol);

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● Sevelamer hydrochloride (Renagel);

● Sevelamer carbonate (Renvela);

● Sucroferric oxyhydroxide (Velphoro); and

● Ferric citrate (Auryxia).

All  of  the  phosphate  binders  listed  above  are  available  as  generics  in  the  U.S.,  with  the  exception  of  Velphoro  and
Auryxia.  In  addition  to  the  currently  available  phosphate  binders,  we  are  aware  of  at  least  two  other  binders  in
development, including fermagate (Alpharen), an iron-based binder in Phase 3 being developed by Opko Health, Inc., and
PT20, an iron-based binder in Phase 3 being developed by Shield Therapeutics.

In  respect  of  tenapanor  for  the  treatment  of  IBS-C,  numerous  treatments  exist  for  constipation  and  the  constipation
component  of  IBS-C,  many  of  which  are  over-the-counter.  These  include  psyllium  husk  (such  as  Metamucil),
methylcellulose (such as Citrucel), calcium polycarbophil (such as FiberCon), lactulose (such as Cephulac), polyethylene
glycol  (such  as  MiraLax),  sennosides  (such  as  Exlax),  bisacodyl  (such  as  Ducolax),  docusate  sodium  (such  as  Colace),
magnesium hydroxide (such as Milk of Magnesia), saline enemas (such as Fleet) and sorbitol. These agents are generally
inexpensive and work well to temporarily relieve constipation.

We are aware of four prescription products marketed for certain patients with IBS-C, including Linzess (linaclotide),

Amitiza (lubiprostone), Trulance (plecanatide) and Zelnorm (tegaserod maleate).

It is possible that our competitors will develop and market drugs or other treatments that are less expensive and more
effective  than  our  product  candidates,  or  that  will  render  our  product  candidates  obsolete.  It  is  also  possible  that  our
competitors  will  commercialize  competing  drugs  or  treatments  before  we  or  our  collaboration  partners  can  launch  any
products developed from our product candidates. We also anticipate that we will face increased competition in the future as
new companies enter into our target markets.

Many of our competitors have materially greater name recognition and financial, manufacturing, marketing, research
and drug development resources than we do. Additional mergers and acquisitions in the biotechnology and pharmaceutical
industries may result in even more resources being concentrated in our competitors. Large pharmaceutical companies in
particular  have  extensive  expertise  in  preclinical  and  clinical  testing  and  in  obtaining  regulatory  approvals  for  drugs.  In
addition, academic institutions, government agencies, and other public and private organizations conducting research may
seek  patent  protection  with  respect  to  potentially  competitive  products  or  technologies.  These  organizations  may  also
establish exclusive collaboration partnerships or licensing relationships with our competitors.

We  may  experience  difficulties  in  managing  our  current  activities  and  growth  given  our  level  of  managerial,
operational, financial and other resources.

While  we  have  continued  to  work  to  optimize  our  management  composition,  personnel  and  systems  to  support  our
current activities for future growth, these resources may not be adequate for this purpose. Our need to effectively execute
our business strategy requires that we:

● manage any commercialization activities in which we may engage effectively;

● manage our clinical trials effectively;

● manage our internal research and development efforts effectively while carrying out our contractual obligations to

licensors, contractors, collaborators, government agencies and other third parties;

● continue to improve our operational, financial and management controls, reporting systems and procedures; and

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● retain and motivate our remaining employees and potentially identify, recruit, and integrate additional employees.

If we are unable to maintain or expand our managerial, operational, financial and other resources to the extent required

to manage our development and commercialization activities, our business will be materially adversely affected.

If  product  liability  lawsuits  are  brought  against  us,  we  may  incur  substantial  liabilities  and  may  be  required  to  limit
commercialization of our product candidates.

We face an inherent risk of product liability as a result of the clinical testing of our product candidates and will face an
even  greater  risk  if  we  commercialize  any  products.  For  example,  we  may  be  sued  if  any  product  we  develop  allegedly
causes  injury  or  is  found  to  be  otherwise  unsuitable  during  product  testing,  manufacturing,  marketing  or  sale.  Any  such
product liability claims may include allegations of defects in manufacturing, defects in design, a failure to warn of dangers
inherent in the product, negligence, strict liability, and a breach of warranties. Claims could also be asserted under state
consumer  protection  acts.  If  we  cannot  successfully  defend  ourselves  against  product  liability  claims,  we  may  incur
substantial liabilities or be required to limit commercialization of our product candidates. Even successful defense would
require significant financial and management resources. Regardless of the merits or eventual outcome, liability claims may
result in:

● decreased demand for our product candidates;

● injury to our reputation;

● withdrawal of clinical trial participants;

● costs to defend the related litigation;

● a diversion of management’s time and our resources;

● substantial monetary awards to trial participants or patients;

● regulatory investigations, product recalls or withdrawals, or labeling, marketing or promotional restrictions;

● loss of revenue; and

● the inability to commercialize or co-promote our product candidates.

Our inability to obtain and maintain sufficient product liability insurance at an acceptable cost and scope of coverage
to  protect  against  potential  product  liability  claims  could  prevent  or  inhibit  the  commercialization  of  any  products  we
develop. Although we maintain product liability insurance, any claim that may be brought against us could result in a court
judgment or settlement in an amount that is not covered, in whole or in part, by our insurance or that is in excess of the
limits  of  our  insurance  coverage.  Our  insurance  policies  also  have  various  exclusions  and  deductibles,  and  we  may  be
subject to a product liability claim for which we have no coverage. We will have to pay any amounts awarded by a court or
negotiated in a settlement that exceed our coverage limitations or that are not covered by our insurance, and we may not
have, or be able to obtain, sufficient capital to pay such amounts. Moreover, in the future, we may not be able to maintain
insurance coverage at a reasonable cost or in sufficient amounts to protect us against losses.

If we fail to attract, retain and motivate our executives, senior management and key personnel, our business will suffer.

Recruiting  and  retaining  qualified  scientific,  clinical,  medical,  manufacturing,  and  sales  and  marketing  personnel  is
critical to our success. We are highly dependent on our executives, senior management and certain other key employees.
The loss of the services of our executives, senior management or other key employee could impede the achievement of our
research, development and commercial objectives and seriously harm our ability to successfully implement our

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business  strategy.  Furthermore,  replacing  executives,  senior  management  and  other  key  employees  may  be  difficult  and
may take an extended period of time because of the limited number of individuals in our industry with the breadth of skills
and  experience  required  to  successfully  develop,  gain  marketing  approval  of  and  commercialize  products.  We  may  be
unable to hire, train or motivate these key personnel on acceptable terms given the intense competition among numerous
biopharmaceutical companies for similar personnel, particularly in our geographic regions. If we are unable to continue to
attract and retain high quality personnel, our ability to grow and pursue our business strategy will be limited.

Our proprietary drug discovery and design platform, and, in particular, APECCS, is a new approach to the discovery,
design  and  development  of  new  product  candidates  and  may  not  result  in  any  products  of  commercial  value.
Furthermore, the APECCS aspects of our drug discovery and design platform may have diminished relevance to our
efforts focused on the discovery of targets and therapies for the treatment of renal diseases.

We have developed a proprietary drug discovery and design platform integrating our proprietary chemistry capabilities
and our APECCs stem cell platform to enable the identification, screening, testing, design and development of new product
candidates, and have developed APECCS as a component of this of this platform. We have utilized APECCS in the design
of our small molecules and to identify new and potentially novel targets in the GI tract. However, there can be no assurance
that APECCS will be able to identify new targets in the GI tract or that any of these potential targets or other aspects of our
proprietary  drug  discovery  and  design  platform  will  yield  product  candidates  that  could  enter  clinical  development  and,
ultimately, be commercially valuable. In addition, as we focus our efforts on the discovery and design of therapies for the
treatment of cardiorenal diseases, we may need to further develop our proprietary drug discovery and design platform to
enhance its usefulness in the identification, screening, testing, design and development of new product candidates for the
treatment of cardiorenal diseases. There can be no assurances that we will be successful in such additional development of
our platform or that our platform will yield product candidates for the treatment of renal diseases.

Actual or perceived failures to comply with applicable data protection, privacy and security laws, regulations, standards
and other requirements could adversely affect our business, results of operations, and financial condition.

The global data protection landscape is rapidly evolving, and we are or may become subject to numerous state, federal
and foreign laws, requirements and regulations governing the collection, use, disclosure, retention, and security of personal
data,  such  as  information  that  we  may  collect  in  connection  with  clinical  trials  in  the  U.S.  and  abroad.  Implementation
standards and enforcement practices are likely to remain uncertain for the foreseeable future, and we cannot yet determine
the impact future laws, regulations, standards, or perception of their requirements may have on our business. This evolution
may create uncertainty in our business, affect our ability to operate in certain jurisdictions or to collect, store, transfer use
and share personal information, necessitate the acceptance of more onerous obligations in our contracts, result in liability
or impose additional costs on us. The cost of compliance with these laws, regulations and standards is high and is likely to
increase in the future. Any failure or perceived failure by us to comply with federal, state or foreign laws or regulation, our
internal policies and procedures or our contracts governing our processing of personal information could result in negative
publicity, government investigations and enforcement actions, claims by third parties and damage to our reputation, any of
which could have a material adverse effect on our operations, financial performance and business.

As our operations and business grow, we may become subject to or affected by new or additional data protection laws
and regulations and face increased scrutiny or attention from regulatory authorities. In the U.S., HIPAA imposes, among
other  things,  certain  standards  relating  to  the  privacy,  security,  transmission  and  breach  reporting  of  individually
identifiable  health  information.  Certain  states  have  also  adopted  comparable  privacy  and  security  laws  and  regulations,
some of which may be more stringent than HIPAA. Such laws and regulations will be subject to interpretation by various
courts  and  other  governmental  authorities,  thus  creating  potentially  complex  compliance  issues  for  us  and  our  future
customers and strategic partners. In addition, California enacted the California Consumer Privacy Act (CCPA) on June 28,
2018, which went into effect on January 1, 2020. The CCPA creates individual privacy rights for California consumers and
increases  the  privacy  and  security  obligations  of  entities  handling  certain  personal  information.  The  CCPA  provides  for
civil penalties for violations, as well as a private right of action for data breaches that is expected to increase data breach
litigation. The CCPA may increase our compliance costs and potential liability, and many similar laws have been proposed
at the federal level and in other states. Further, the California Privacy Rights Act (CPRA) recently passed in California. The
CPRA will impose additional data protection obligations on covered businesses, including additional

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consumer rights processes, limitations on data uses, new audit requirements for higher risk data, and opt outs for certain
uses of sensitive data. It will also create a new California data protection agency authorized to issue substantive regulations
and  could  result  in  increased  privacy  and  information  security  enforcement.  The  majority  of  the  provisions  will  go  into
effect on January 1, 2023, and additional compliance investment and potential business process changes may be required.
In  the  event  that  we  are  subject  to  or  affected  by  HIPAA,  the  CCPA,  the  CPRA  or  other  domestic  privacy  and  data
protection  laws,  any  liability  from  failure  to  comply  with  the  requirements  of  these  laws  could  adversely  affect  our
financial condition.

In  Europe,  the  European  Union  General  Data  Protection  Regulation  (GDPR)  went  into  effect  in  May  2018  and
imposes  strict  requirements  for  processing  the  personal  data  of  individuals  within  the  European  Economic  Area  (EEA).
Companies  that  must  comply  with  the  GDPR  face  increased  compliance  obligations  and  risk,  including  more  robust
regulatory enforcement of data protection requirements and potential fines for noncompliance of up to €20 million or 4%
of  the  annual  global  revenues  of  the  noncompliant  company,  whichever  is  greater.  Relatedly,  following  the  United
Kingdom’s withdrawal from the European Economic Area and the European Union, and the expiry of the transition period,
companies  have  to  comply  with  both  the  GDPR  and  the  GDPR  as  incorporated  into  United  Kingdom  national  law,  the
latter  regime  having  the  ability  to  separately  fine  up  to  the  greater  of  £17.5  million  or  4%  of  global  turnover.  The
relationship  between  the  United  Kingdom  and  the  European  Union  in  relation  to  certain  aspects  of  data  protection  law
remains unclear, for example around how data can lawfully be transferred between each jurisdiction, which may expose us
to further compliance risk.

Although we work to comply with applicable laws, regulations and standards, our contractual obligations and other
legal obligations, these requirements are evolving and may be modified, interpreted and applied in an inconsistent manner
from one jurisdiction to another, and may conflict with one another or other legal obligations with which we must comply.
Any failure or perceived failure by us or our employees, representatives, contractors, consultants, CROs, collaborators, or
other  third  parties  to  comply  with  such  requirements  or  adequately  address  privacy  and  security  concerns,  even  if
unfounded, could result in additional cost and liability to us, damage our reputation, and adversely affect our business and
results of operations.

We and our collaborators, CROs and other contractors and consultants depend on information technology systems, and
any  failure  of  these  systems  could  harm  our  business.  Security  breaches,  loss  of  data,  and  other  disruptions  could
compromise sensitive information related to our business or prevent us from accessing critical information and expose
us to liability, which could adversely affect our business, results of operations and financial condition.

We  and  our  collaborators,  CROs,  and  other  contractors  and  consultants  collect  and  maintain  information  in  digital
form that is necessary to conduct our business, and we are increasingly dependent on information technology systems and
infrastructure to operate our business. In the ordinary course of our business, we and our collaborators, CROs and other
contractors  and  consultants  collect,  store  and  transmit  large  amounts  of  confidential  information,  including  intellectual
property, proprietary business information and personal information. It is critical that we and our collaborators, CROs and
other contractors and consultants do so in a secure manner to maintain the confidentiality and integrity of such confidential
information. We have established physical, electronic and organizational measures to safeguard and secure our systems to
prevent  a  data  compromise,  and  rely  on  commercially  available  systems,  software,  tools,  and  monitoring  to  provide
security for our information technology systems and the processing, transmission and storage of digital information. We
have also outsourced elements of our information technology infrastructure, and as a result a number of third-party vendors
may or could have access to our confidential information. Our internal information technology systems and infrastructure,
and those of our current and any future collaborators, CROs, contractors and consultants and other third parties on which
we  rely,  are  vulnerable  to  damage  from  computer  viruses,  malware,  natural  disasters,  terrorism,  war,  telecommunication
and  electrical  failures,  cyber-attacks  or  cyber-intrusions  over  the  Internet,  attachments  to  emails,  persons  inside  our
organization, or persons with access to systems inside our organization.

The risk of a security breach or disruption or data loss, particularly through cyber-attacks or cyber intrusion, including
by  computer  hackers,  foreign  governments  and  cyber  terrorists,  has  generally  increased  as  the  number,  intensity  and
sophistication of attempted attacks and intrusions from around the world have increased. In addition, the prevalent use of
mobile  devices  that  access  confidential  information  increases  the  risk  of  data  security  breaches,  which  could  lead  to  the
loss of confidential information or other intellectual property. As a result of the COVID-19 pandemic, we may also face

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increased cybersecurity risks due to our reliance on internet technology and the number of our employees who are working
remotely, which may create additional opportunities for cybercriminals to exploit vulnerabilities. Furthermore, because the
techniques used to obtain unauthorized access to, or to sabotage, systems change frequently and often are not recognized
until  launched  against  a  target,  we  may  be  unable  to  anticipate  these  techniques  or  implement  adequate  preventative
measures. We may also experience security breaches that may remain undetected for an extended period. The costs to us to
mitigate network security problems, bugs, viruses, worms, malicious software programs and security vulnerabilities could
be significant, and while we have implemented security measures to protect our data security and information technology
systems,  our  efforts  to  address  these  problems  may  not  be  successful,  and  these  problems  could  result  in  unexpected
interruptions,  delays,  cessation  of  service  and  other  harm  to  our  business  and  our  competitive  position.  If  such  an  event
were to occur and cause interruptions in our operations, it could result in a material disruption of our product development
programs,  and/or  of  our  efforts  to  commercialize  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on
dialysis, if approved. For example, the loss of clinical trial data from completed or ongoing or planned clinical trials could
result in delays in our regulatory approval efforts and significantly increase our costs to recover or reproduce the data. In
addition,  such  a  breach  may  require  notification  to  governmental  agencies,  the  media  or  individuals  pursuant  to  various
federal and state privacy and security laws, if applicable, including HIPAA. Moreover, if a computer security breach affects
our systems or those of our collaborators, CROs or other contractors, or results in the unauthorized release of personally
identifiable  information,  our  reputation  could  be  materially  damaged.  We  would  also  be  exposed  to  a  risk  of  loss  or
litigation and potential liability, which could materially adversely affect our business, results of operations and financial
condition.

Actual  or  perceived  failures  to  comply  with  applicable  data  protection,  privacy  and  security  laws,  regulations,

standards and other requirements could adversely affect our business, results of operations, and financial condition.

The global data protection landscape is rapidly evolving, and we are or may become subject to numerous state, federal
and foreign laws, requirements and regulations governing the collection, use, disclosure, retention, and security of personal
data. Implementation standards and enforcement practices are likely to remain uncertain for the foreseeable future, and we
cannot yet determine the impact future laws, regulations, standards, or perception of their requirements may have on our
business. This evolution may create uncertainty in our business, affect our ability to operate in certain jurisdictions or to
collect, store, transfer use and share personal information, necessitate the acceptance of more onerous obligations in our
contracts,  result  in  liability  or  impose  additional  costs  on  us.  The  cost  of  compliance  with  these  laws,  regulations  and
standards is high and is likely to increase in the future. Any failure or perceived failure by us to comply with federal, state
or foreign laws or regulation, our internal policies and procedures or our contracts governing our processing of personal
information could result in negative publicity, government investigations and enforcement actions, claims by third parties
and damage to our reputation, any of which could have a material adverse effect on our operations, financial performance
and business.

As our operations and business grow, we may become subject to or affected by new or additional data protection laws
and regulations and face increased scrutiny or attention from regulatory authorities. In the U.S., HIPAA imposes, among
other  things,  certain  standards  relating  to  the  privacy,  security,  transmission  and  breach  reporting  of  individually
identifiable  health  information.  Certain  states  have  also  adopted  comparable  privacy  and  security  laws  and  regulations,
some of which may be more stringent than HIPAA. Such laws and regulations will be subject to interpretation by various
courts  and  other  governmental  authorities,  thus  creating  potentially  complex  compliance  issues  for  us  and  our  future
customers  and  strategic  partners.  Even  when  HIPAA  does  not  apply,  according  to  the  Federal  Trade  Commission  (the
“FTC”)  failing  to  take  appropriate  steps  to  keep  consumers’  personnel  information  secure  constitutes  unfair  acts  or
practices in or affecting commerce in violation of Section 5(a) of the Federal Trade CommissionFTC Act (the “FTCA”) 15
U.S.  C  §  45(a).  The  FTC  expects  a  company’s  data  security  measures  to  be  reasonable  and  appropriate  in  light  of  the
sensitivity and volume of consumer information it holds, the size and complexity of its business, and the cost of available
tools  to  improve  security  and  reduce  vulnerabilities.  Individually  identifiable  health  information  is  considered  sensitive
data  that  merits  stronger  safeguards.  The  FTC’s  guidance  for  appropriately  securing  consumers’  personal  information  is
similar  to  what  is  required  by  the  HIPAA  Security  Rule.  We  may  also  be  subject  to  state  laws  requiring  notification  of
affected  individuals  and  state  regulators  in  the  event  of  a  breach  of  personal  information,  which  is  a  broader  class  of
information  than  the  health  information  protected  by  HIPAA.  For  example,  California  recently  enacted  legislation,  the
California  Consumer  Privacy  Act  (“CCPA”)theCCPA,  which  went  into  effect  January  1,  2020.  The  CCPA,  among  other
things, creates new data privacy obligations for covered companies and provides new privacy rights to California residents,

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including the right to opt out of certain disclosures of their information. The CCPA also creates a private right of action
with  statutory  damages  for  certain  data  breaches,  thereby  potentially  increasing  risks  associated  with  a  data  breach.
Although the law includes limited exceptions, including for “protected health information” maintained by a covered entity
or business associate, it may regulate or impact our processing of personal information depending on the context. Further,
the  CPRA  recently  passed  in  California.  The  CPRA  will  impose  additional  data  protection  obligations  on  covered
businesses, including additional consumer rights processes, limitations on data uses, new audit requirements for higher risk
data, and opt outs for certain uses of sensitive data. It will also create a new California data protection agency authorized to
issue substantive regulations and could result in increased privacy and information security enforcement. The majority of
the provisions will go into effect on January 1, 2023, and additional compliance investment and potential business process
changes may be required.

Although we work to comply with applicable laws, regulations and standards, our contractual obligations and other legal
obligations, these requirements are evolving and may be modified, interpreted and applied in an inconsistent manner from
one jurisdiction to another, and may conflict with one another or other legal obligations with which we must comply. Any
failure or perceived failure by us or our employees, representatives, contractors, consultants, collaborators, or other third
parties to comply with such requirements or adequately address privacy and security concerns, even if unfounded, could
result  in  additional  cost  and  liability  to  us,  damage  our  reputation,  and  adversely  affect  our  business  and  results  of
operations.

We have previously identified a material weakness in our internal control over financial reporting. If we fail to maintain
proper and effective internal controls, our ability to produce accurate and timely financial statements could be impaired,
which could harm our operating results, our ability to operate our business and investors’ views of us and could have a
material adverse effect on the price of our common stock.

In  2019,  management  and  our  independent  registered  public  accounting  firm  identified  a  control  deficiency  that
constituted a material weakness in our internal control over financial reporting. The material weakness was due to a failure
in the design and implementation of controls over the evaluation of the terms of our clinical trial contracts for inclusion
into our clinical financial model which estimates clinical trial expenses. Specifically, we had failed to properly interpret an
expense in our clinical trial contracts which resulted in the over accrual of our clinical trial expenses during 2018 and the
first quarter of 2019.

We  developed  and  implemented  a  remediation  plan  for  this  material  weakness  which  included  modifications  to  the
design  and  implementation  of  certain  internal  controls,  and  the  material  weakness  was  remediated  as  of  December  31,
2019. Although we have remediated this material weakness, as attested by our independent registered public accounting
firm, we can give no assurance that an additional material weakness or significant deficiency in our internal controls over
financial  reporting  will  not  be  identified  in  the  future.  Our  failure  to  implement  and  maintain  effective  internal  controls
over financial reporting could result in errors in our financial statements that could result in a restatement of our financial
statements  and  cause  us  to  fail  to  meet  our  reporting  obligations.  If  we  cannot  in  the  future  favorably  assess  the
effectiveness of our internal controls over financial reporting, investor confidence in the reliability of our financial reports
may be adversely affected, which could have a material adverse effect on the trading price of our common stock.

We  have  formed  in  the  past,  and  may  form  in  the  future,  collaboration  partnerships,  joint  ventures  and/or  licensing
arrangements, and we may not realize the benefits of such collaborations.

We have current collaboration partnerships for the commercialization of tenapanor in certain foreign countries, and we
may form additional collaboration partnerships, create joint ventures or enter into additional licensing arrangements with
third  parties  in  the  United  States  and  abroad  that  we  believe  will  complement  or  augment  our  existing  business.  In
particular, we have formed collaboration partnerships with Kyowa Kirin Co. , Ltd. (“KKC”) for certain research programs
and for commercialization of tenapanor for hyperphosphatemia in Japan; with Shanghai Fosun Pharmaceutical Industrial
Development Co. Ltd. (“Fosun Pharma”) for commercialization of tenapanor for hyperphosphatemia and IBS-C in China
and  related  territories;  and  in  Canada  with  Knight  Therapeutics,  Inc.  (“Knight”)  for  commercialization  of  tenapanor  for
IBS-C  and  hyperphosphatemia.  We  face  significant  competition  in  seeking  appropriate  collaboration  partners,  and  the
process to identify an appropriate partner and negotiate appropriate terms is time-consuming and complex. Any delays in
identifying suitable additional collaboration partners and entering into agreements to develop our product candidates could

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also delay the commercialization of our product candidates, which may reduce their competitiveness even if they reach the
market.  There  is  no  guarantee  that  our  current  collaboration  partnerships  or  any  such  arrangements  we  enter  into  in  the
future will be successful, or that any collaboration partner will commit sufficient resources to the development, regulatory
approval, and commercialization effort for such products, or that such alliances will result in us achieving revenues that
justify such transactions.

The ongoing COVID-19 pandemic, or any other outbreak of epidemic diseases, or the perception of their effects, could
have a material adverse effect on our business, financial condition, results of operations or cash flows.

Outbreaks  of  epidemic,  pandemic,  or  contagious  diseases,  such  as  the  current  novel  coronavirus  (“COVID-19”)
pandemic or, historically, the Ebola virus, Middle East Respiratory Syndrome, Severe Acute Respiratory Syndrome, or the
H1N1  virus,  could  disrupt  our  business.  Business  disruptions  could  include  disruptions  or  restrictions  on  our  ability  to
conduct our clinical trials, as planned, travel, as well as temporary closures of the facilities of our collaboration partners,
suppliers  or  contract  manufacturers.  Any  disruption  of  our  clinical  trial  operations,  collaboration  partners,  suppliers  or
contract manufacturers could adversely impact our operating results.

While  the  COVID-19  pandemic  did  not  materially  adversely  affect  our  business  operations  in  the  year  ended
December 31, 2020, economic and health conditions in the United States and across most of the globe remain uncertain
and  continue  to  evolve.  While  at  this  point,  the  extent  to  which  the  coronavirus  outbreak  may  impact  our  results  is
uncertain, it could result in delays in the manufacture of tenapanor, or in the delivery of key intermediates or raw materials
required to manufacture tenapanor or delays in clinical development activities by us, or our collaboration partners. It could
also  materially  and  negatively  impact  our  ability,  either  alone,  or  with  a  collaboration  partner,  to  successfully
commercialize tenapanor, if approved for marketing and sale by the FDA or foreign regulatory authorities, including our
ability to educate physicians and patients about the benefits, administration and use of tenapanor.

● As  a  result  of  the  COVID-19  pandemic,  we  may  also  experience  disruptions  that  could  severely  impact  our

business, preclinical studies and clinical trials, including:

● While  our  Phase  3  clinical  development  of  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on
dialysis is complete, we have ongoing and planned clinical trials for tenapanor and an ongoing Phase 2 clinical
trial for RDX013, any of which may be delayed as a result the COVID-19 outbreak. Other potential impacts of
the COVID-19 pandemic on our various clinical trials include delays or difficulties in any planned clinical site
initiation,  including  difficulties  in  obtaining  Institutional  Review  Board  approvals,  recruiting  clinical  site
investigators and clinical site staff, delays or difficulties in enrolling patients, interruption of planned key clinical
trial activities, such as clinical trial site data monitoring due to diversion of resources at clinical sites or limitation
on travel imposed by federal or state governments.

● We have limited the use of our offices to essential employees and requested that most of our personnel, including
all of our administrative employees, work remotely. We have restricted on-site staff to only those personnel and
contractors who must perform essential activities that must be completed on-site and limited the number of staff
in  our  research  laboratories.  The  COVID-19  pandemic  could  disrupt  our  ability  to  secure  supplies  for  our
facilities and to provide personal protective equipment for our employees. The safety, health and well-being of
our workforce is of primary concern and we may need to enact further precautionary measures to help minimize
the risk of our employees being exposed to the novel coronavirus.

● Our increased reliance on personnel working from home may negatively impact productivity, or disrupt, delay, or
otherwise  adversely  impact  our  business.  In  addition,  this  could  increase  our  cyber-security  risk,  create  data
accessibility  concerns,  and  make  us  more  susceptible  to  communication  disruptions,  any  of  which  could
adversely impact our business operations or delay necessary interactions with local and federal regulators, ethics
committees, manufacturing sites, research or clinical trial sites and important agencies and contractors.

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● The FDA and comparable foreign regulatory agencies may experience operational interruptions or delays, which

may impact timelines for regulatory submission, trial initiation and regulatory approval.

The  COVID-19  outbreak  continues  to  rapidly  evolve.  The  extent  to  which  the  outbreak  may  impact  our  business,
manufacturing,  preclinical  development  activities,  preclinical  studies  and  planned  clinical  trials  will  depend  on  future
developments, which are highly uncertain and cannot be predicted with confidence, such as the ultimate geographic spread
of COVID-19, the duration of the outbreak, travel restrictions and actions to contain the outbreak or treat its impact, such
as social distancing and quarantines or lock-downs in the United States and other countries, business closures or business
disruptions and the effectiveness of actions taken in the United States and other countries to contain and treat the disease.

We may engage in strategic transactions that could impact our liquidity, increase our expenses and present significant
distractions to our management.

We  may  consider  strategic  transactions,  such  as  acquisitions  of  companies,  asset  purchases,  and/or  in-licensing  of
products, product candidates or technologies. In addition, if we are unable to access capital on a timely basis and on terms
that are acceptable to us, we may be forced to restructure certain aspects of our business or identify and complete one or
more  strategic  collaborations  or  other  transactions  in  order  to  fund  the  development  or  commercialization  of  tenapanor
and/or  the  development  of  RDX013  or  certain  of  our  other  product  candidates  through  the  use  of  alternative  structures.
Additional potential transactions that we may consider include a variety of different business arrangements, including spin-
offs,  spin  outs,  collaboration  partnerships,  joint  ventures,  restructurings,  divestitures,  business  combinations  and
investments. Any such transaction may require us to incur non-recurring or other charges, may increase our near- and long-
term  expenditures  and  may  pose  significant  integration  challenges  or  disrupt  our  management  or  business,  which  could
adversely affect our operations and financial results. For example, these transactions may entail numerous operational and
financial risks, including:

● up-front,  milestone  and  royalty  payments,  equity  investments  and  financial  support  of  new  research  and

development candidates including increase of personnel, all of which may be substantial;

● exposure to unknown liabilities;

● disruption  of  our  business  and  diversion  of  our  management’s  time  and  attention  in  order  to  develop  acquired

products, product candidates or technologies;

● incurrence of substantial debt or dilutive issuances of equity securities;

● higher-than-expected acquisition and integration costs;

● write-downs of assets or goodwill or impairment charges;

● increased amortization expenses;

● difficulty and cost in combining the operations and personnel of any acquired businesses with our operations and

personnel;

● impairment  of  relationships  with  key  suppliers  or  customers  of  any  acquired  businesses  due  to  changes  in

management and ownership; and

● inability to retain key employees of any acquired businesses.

Accordingly, although there can be no assurance that we will undertake or successfully complete any transactions of
the nature described above, any transactions that we do complete may be subject to the foregoing or other risks and could
have a material adverse effect on our business, results of operations, financial condition and prospects.

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If we seek and obtain approval to commercialize our product candidates outside of the United States, manufacture our
product candidates outside of the United States, or otherwise engage in business outside of the United States, a variety
of risks associated with international operations could materially adversely affect our business.

We or our collaboration partners may decide to seek marketing approval for certain of our product candidates outside
the United States or otherwise engage in business outside the United States, including entering into contractual agreements
with  third-parties.  We  currently  utilize  contract  manufacturing  organizations  located  outside  of  the  United  States  to
manufacture  our  active  drug  substance  for  tenapanor.  We  are  subject  to  additional  risks  related  to  entering  these
international business markets and relationships, including:

● different regulatory requirements for drug approvals in foreign countries;

● differing United States and foreign drug import and export rules;

● reduced protection for intellectual property rights in foreign countries;

● unexpected changes in tariffs, trade barriers and regulatory requirements;

● different reimbursement systems, and different competitive drugs;

● economic weakness, including inflation, or political instability in particular foreign economies and markets;

● compliance with tax, employment, immigration and labor laws for employees living or traveling abroad;

● foreign taxes, including withholding of payroll taxes;

● foreign currency fluctuations, which could result in increased operating expenses and reduced revenues, and other

obligations incident to doing business in another country;

● workforce uncertainty in countries where labor unrest is more common than in the United States;

● production  shortages  resulting  from  any  events  affecting  raw  material  supply  or  manufacturing  capabilities

abroad;

● potential liability resulting from development work conducted by these distributors; and

● business interruptions resulting from geopolitical actions, including war and terrorism, or natural disasters.

Our business involves the use of hazardous materials and we and third-parties with whom we contract must comply with
environmental laws and regulations, which can be expensive and restrict how we do business.

Our  research  and  development  activities  involve  the  controlled  storage,  use  and  disposal  of  hazardous  materials,
including the components of our product candidates and other hazardous compounds. We and manufacturers and suppliers
with  whom  we  may  contract  are  subject  to  laws  and  regulations  governing  the  use,  manufacture,  storage,  handling  and
disposal of these hazardous materials. In some cases, these hazardous materials and various wastes resulting from their use
are  stored  at  our  and  our  manufacturers’  facilities  pending  their  use  and  disposal.  We  cannot  eliminate  the  risk  of
contamination, which could cause an interruption of our commercialization efforts, research and development efforts and
business  operations,  environmental  damage  resulting  in  costly  clean-up  and  liabilities  under  applicable  laws  and
regulations governing the use, storage, handling and disposal of these materials and specified waste products. We cannot
guarantee that the safety procedures utilized by third-party manufacturers and suppliers with whom we may contract will
comply  with  the  standards  prescribed  by  laws  and  regulations  or  will  eliminate  the  risk  of  accidental  contamination  or
injury from these materials. In such an event, we may be held liable for any resulting damages and such liability could

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exceed  our  resources  and  state  or  federal  or  other  applicable  authorities  may  curtail  our  use  of  certain  materials  and/or
interrupt  our  business  operations.  Furthermore,  environmental  laws  and  regulations  are  complex,  change  frequently  and
have tended to become more stringent. We cannot predict the impact of such changes and cannot be certain of our future
compliance. We do not currently carry biological or hazardous waste insurance coverage.

We  may  be  adversely  affected  by  earthquakes  or  other  natural  disasters  and  our  business  continuity  and  disaster
recovery plans may not adequately protect us from a serious disaster.

We have dual headquarters and one of our facilities is located in the San Francisco Bay Area, which in the past has
experienced  severe  earthquakes.  We  do  not  carry  earthquake  insurance.  Earthquakes  or  other  natural  disasters  could
severely  disrupt  our  operations,  and  have  a  material  adverse  effect  on  our  business,  results  of  operations,  financial
condition and prospects.

If a natural disaster, power outage or other event occurred that prevented us from using all or a significant portion of
our  California  facility,  that  damaged  critical  infrastructure,  such  as  our  enterprise  financial  systems  or  manufacturing
resource planning and enterprise quality systems, or that otherwise disrupted operations, it may be difficult or, in certain
cases,  impossible  for  us  to  continue  our  business  for  a  substantial  period  of  time.  The  disaster  recovery  and  business
continuity plans we have in place currently are limited and are unlikely to prove adequate in the event of a serious disaster
or similar event. We may incur substantial expenses as a result of the limited nature of our disaster recovery and business
continuity  plans,  which,  particularly  when  taken  together  with  our  lack  of  earthquake  insurance,  could  have  a  material
adverse effect on our business.

Risks Related to Government Regulation

The  regulatory  approval  processes  of  the  FDA  and  comparable  foreign  authorities  are  lengthy,  time  consuming  and
inherently  unpredictable.  If  we  are  ultimately  unable  to  obtain  regulatory  approval  for  our  product  candidates,  our
business will be substantially harmed.

The  research,  testing,  manufacturing,  labeling,  approval,  selling,  import,  export,  marketing  and  distribution  of  drug
products  are  subject  to  extensive  regulation  by  the  FDA  and  other  regulatory  authorities  in  the  United  States  and  other
countries, which regulations differ from country to country. Neither we nor any of our collaboration partners is permitted to
market  any  drug  product  in  the  United  States  until  we  receive  marketing  approval  from  the  FDA.  Obtaining  regulatory
approval of a NDA can be a lengthy, expensive and uncertain process. In addition, failure to comply with FDA and other
applicable  United  States  and  foreign  regulatory  requirements  may  subject  us  to  administrative  or  judicially  imposed
sanctions or other actions, including:

● warning or untitled letters;

● civil and criminal penalties;

● injunctions;

● withdrawal of regulatory approval of products;

● product seizure or detention;

● product recalls;

● total or partial suspension of production; and

● refusal to approve pending NDAs or supplements to approved NDAs.

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Prior to obtaining approval to commercialize a drug candidate in the United States or abroad, we or our collaboration
partners must demonstrate with substantial evidence from well-controlled clinical trials, and to the satisfaction of the FDA
or other foreign regulatory agencies, that such drug candidates are safe and effective for their intended uses. The number of
nonclinical studies and clinical trials that will be required for FDA approval varies depending on the drug candidate, the
disease or condition that the drug candidate is designed to address, and the regulations applicable to any particular drug
candidate. Results from nonclinical studies and clinical trials can be interpreted in different ways. Even if we believe the
nonclinical or clinical data for our drug candidates are promising, such data may not be sufficient to support approval by
the FDA and other regulatory authorities. Administering drug candidates to humans may produce undesirable side effects,
which could interrupt, delay or halt clinical trials and result in the FDA or other regulatory authorities denying approval of
a drug candidate for any or all targeted indications.

The time required to obtain approval by the FDA and comparable foreign authorities is unpredictable, typically takes
many  years  following  the  commencement  of  clinical  studies  and  depends  upon  numerous  factors.  The  FDA  and
comparable foreign authorities have substantial discretion in the approval process and we may encounter matters with the
FDA  or  such  comparable  authorities  that  requires  us  to  expend  additional  time  and  resources  and  delay  or  prevent  the
approval of our product candidates. For example, the FDA may require us to conduct additional studies for a drug product
either  prior  to  or  post-approval,  such  as  additional  drug-drug  interaction  studies  or  safety  or  efficacy  studies,  or  it  may
object to elements of our clinical development program such as the number of subjects in our current clinical trials from the
United States. In addition, approval policies, regulations or the type and amount of clinical data necessary to gain approval
may change during the course of a product candidate’s clinical development and may vary among jurisdictions, which may
cause delays in the approval or result in a decision not to approve an application for regulatory approval. Despite the time
and expense exerted, failure can occur at any stage.

Applications for our product candidates could fail to receive regulatory approval for many reasons, including but not

limited to the following:

● the FDA or comparable foreign regulatory authorities may disagree with the design or implementation of our, or

our collaboration partners’, clinical studies;

● the population studied in the clinical program may not be sufficiently broad or representative to assure safety in

the full population for which approval is sought;

● the  FDA  or  comparable  foreign  regulatory  authorities  may  disagree  with  the  interpretation  of  data  from

preclinical studies or clinical studies;

● the data collected from clinical studies of our product candidates may not be sufficient to support the submission

of a NDA or other submission or to obtain regulatory approval in the United States or elsewhere;

● we  or  our  collaboration  partners  may  be  unable  to  demonstrate  to  the  FDA  or  comparable  foreign  regulatory

authorities that a product candidate’s risk-benefit ratio for its proposed indication is acceptable;

● the  FDA  or  comparable  foreign  regulatory  authorities  may  fail  to  approve  the  manufacturing  processes,  test
procedures and specifications, or facilities of third-party manufacturers responsible for clinical and commercial
supplies; and

● the  approval  policies  or  regulations  of  the  FDA  or  comparable  foreign  regulatory  authorities  may  significantly

change in a manner rendering our clinical data insufficient for approval.

This lengthy approval process, as well as the unpredictability of the results of clinical studies, may result in our failure
and/or  that  of  our  collaboration  partners  to  obtain  regulatory  approval  to  market  any  of  our  product  candidates,  which
would  significantly  harm  our  business,  results  of  operations,  and  prospects.  Additionally,  if  the  FDA  requires  that  we
conduct  additional  clinical  studies,  places  limitations  in  our  label,  delays  approval  to  market  our  product  candidates  or
limits the use of our products, our business and results of operations may be harmed.

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In addition, even if we were to obtain approval, regulatory authorities may approve any of our product candidates for
fewer or more limited indications than we request, may not approve the price we intend to charge for our products, may
grant approval contingent on the performance of costly post-marketing clinical trials, or may approve a product candidate
with a label that does not include the labeling claims necessary or desirable for the successful commercialization of that
product  candidate.  Any  of  the  foregoing  scenarios  could  materially  harm  the  commercial  prospects  for  our  product
candidates.

Even if we receive regulatory approval for a product candidate, we will be subject to ongoing regulatory obligations and
continued regulatory review, which may result in significant additional expense. Additionally, any product candidates, if
approved, could be subject to labeling and other restrictions and market withdrawal, and we may be subject to penalties
if we fail to comply with regulatory requirements or experience unanticipated problems with our products.

Even  if  a  drug  is  approved  by  the  FDA  or  foreign  regulatory  authorities,  the  manufacturing  processes,  labeling,
packaging, distribution, adverse event reporting, storage, advertising, promotion and recordkeeping for the product will be
subject  to  extensive  and  ongoing  regulatory  requirements.  These  requirements  include  submissions  of  safety  and  other
post-marketing information and reports, registration, as well as continued compliance with cGMPs and GCP regulations
for any clinical trials that we conduct post-approval. As such, we and our third-party contract manufacturers will be subject
to  continual  review  and  periodic  inspections  to  assess  compliance  with  regulatory  requirements.  Accordingly,  we  and
others  with  whom  we  work  must  continue  to  expend  time,  money,  and  effort  in  all  areas  of  regulatory  compliance,
including manufacturing, production, and quality control. Regulatory authorities may also impose significant restrictions
on a product’s indicated uses or marketing or impose ongoing requirements for potentially costly post-marketing studies.
Furthermore,  any  new  legislation  addressing  drug  safety  issues  could  result  in  delays  or  increased  costs  to  assure
compliance.

We  will  also  be  required  to  report  certain  adverse  reactions  and  production  problems,  if  any,  to  the  FDA,  and  to
comply  with  requirements  concerning  advertising  and  promotion  for  our  products.  Promotional  communications  with
respect  to  prescription  drugs  are  subject  to  a  variety  of  legal  and  regulatory  restrictions  and  must  be  consistent  with  the
information in the product’s approved label. As such, we may not promote our products for indications or uses for which
they do not have FDA approval.

Later discovery of previously unknown problems with a product, including adverse events of unanticipated severity or
frequency,  or  with  our  third-party  manufacturers  or  manufacturing  processes,  or  failure  to  comply  with  regulatory
requirements, may result in, among other things:

● warning or untitled letters, fines or holds on clinical trials;

● restrictions  on  the  marketing  or  manufacturing  of  the  product,  withdrawal  of  the  product  from  the  market  or

voluntary or mandatory product recalls;

● injunctions or the imposition of civil or criminal penalties;

● suspension or revocation of existing regulatory approvals;

● suspension of any of our ongoing clinical trials;

● refusal to approve pending applications or supplements to approved applications submitted by us;

● restrictions on our or our contract manufacturers’ operations; or

● product seizure or detention, or refusal to permit the import or export of products.

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Any government investigation of alleged violations of law could require us to expend significant time and resources in
response  and  could  generate  negative  publicity.  Any  failure  to  comply  with  ongoing  regulatory  requirements  may
significantly and adversely affect our ability to commercialize our product candidates. If regulatory sanctions are applied or
if regulatory approval is withdrawn, the value of our company and our operating results will be adversely affected.

In addition, the FDA’s policies may change, and additional government regulations may be enacted that could prevent,
limit  or  delay  regulatory  approval  of  our  product  candidates.  If  we  are  slow  or  unable  to  adapt  to  changes  in  existing
requirements or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we
may  lose  any  marketing  approval  that  we  may  have  obtained,  which  would  adversely  affect  our  business,  prospects  and
ability to achieve or sustain profitability.

We also cannot predict the likelihood, nature or extent of government regulation that may arise from future legislation
or administrative or executive action, either in the United States or abroad. For example, the results of the 2020 President
election may impact our business and industry. Namely, the Trump administration took several executive actions, including
the issuance of a number of Executive Orders, that could impose significant burdens on, or otherwise materially delay, the
FDA's ability to engage in routine regulatory and oversight activities such as implementing statutes through rulemaking,
issuance  of  guidance,  and  review  and  approval  of  marketing  applications.  It  is  difficult  to  predict  whether  or  how  these
Executive Orders will be implemented, or whether they will be rescinded or replaced under a Biden Administration. The
policies and priorities of an incoming administration are unknown, and could materially impact the regulatory framework
governing our products.

Disruptions at the FDA and other government agencies caused by funding shortages or global health concerns could
hinder  their  ability  to  hire  and  retain  key  leadership  and  other  personnel,  or  otherwise  prevent  new  products  and
services from being developed or commercialized in a timely manner, which could negatively impact our business.

The  ability  of  the  FDA  to  review  and  approve  new  products  can  be  affected  by  a  variety  of  factors,  including
government budget and funding levels, ability to hire and retain key personnel and accept the payment of user fees, and
statutory, regulatory, and policy changes. Average review times at the agency have fluctuated in recent years as a result. In
addition, government funding of other government agencies that fund research and development activities is subject to the
political process, which is inherently fluid and unpredictable.

Disruptions  at  the  FDA  and  other  agencies  may  also  slow  the  time  necessary  for  new  drugs  to  be  reviewed  and/or
approved by necessary government agencies, which would adversely affect our business. For example, over the last several
years,  including  for  35  days  beginning  on  December  22,  2018,  the  U.S.  government  has  shut  down  several  times  and
certain regulatory agencies, such as the FDA, have had to furlough critical FDA employees and stop critical activities. If a
prolonged government shutdown occurs, it could significantly impact the ability of the FDA to timely review and process
our regulatory submissions, which could have a material adverse effect on our business.

Separately, in response to the global COVID-19 pandemic, on March 10, 2020, the FDA announced its intention to
postpone  most  foreign  inspections  of  manufacturing  facilities  and  products  through  April  2020,  and  subsequently,  on
March  18,  2020,  the  FDA  temporarily  postponed  routine  surveillance  inspections  of  domestic  manufacturing  facilities.
Subsequently,  on  July  10,  2020  the  FDA  announced  its  intention  to  resume  certain  on-site  inspections  of  domestic
manufacturing facilities subject to a risk-based prioritization system. The FDA intends to use this risk-based assessment
system to identify the categories of regulatory activity that can occur within a given geographic area, ranging from mission
critical inspections to resumption of all regulatory activities. Regulatory authorities outside the United States may adopt
similar restrictions or other policy measures in response to the COVID-19 pandemic. If a prolonged government shutdown
occurs,  or  if  global  health  concerns  continue  to  prevent  the  FDA  or  other  regulatory  authorities  from  conducting  their
regular  inspections,  reviews,  or  other  regulatory  activities,  it  could  significantly  impact  the  ability  of  the  FDA  or  other
regulatory authorities to timely review and process our regulatory submissions, which could have a material adverse effect
on our business.

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We  and  our  contract  manufacturers  are  subject  to  significant  regulation  with  respect  to  manufacturing  our  product
candidates. The manufacturing facilities on which we rely may not continue to meet regulatory requirements or may not
be able to meet supply demands.

All  entities  involved  in  the  preparation  of  product  candidates  for  clinical  studies  or  commercial  sale,  including  our
existing contract manufacturers for our product candidates are subject to extensive regulation. Components of a finished
therapeutic product approved for commercial sale or used in late-stage clinical studies must be manufactured in accordance
with cGMP regulations. These regulations govern manufacturing processes and procedures (including record keeping) and
the  implementation  and  operation  of  quality  systems  to  control  and  assure  the  quality  of  investigational  products  and
products  approved  for  sale.  Poor  control  of  production  processes  can  lead  to  the  introduction  of  contaminants  or  to
inadvertent  changes  in  the  properties  or  stability  of  our  product  candidates  that  may  not  be  detectable  in  final  product
testing. We or our contract manufacturers must supply all necessary documentation in support of an NDA or comparable
regulatory  filing  on  a  timely  basis  and  must  adhere  to  cGMP  regulations  enforced  by  the  FDA  and  other  regulatory
agencies through their facilities inspection programs. The facilities and quality systems of some or all of our third-party
contractors must pass a pre-approval inspection for compliance with the applicable regulations as a condition of regulatory
approval  of  our  product  candidates.  In  addition,  the  regulatory  authorities  may,  at  any  time,  audit  or  inspect  a
manufacturing  facility  involved  with  the  preparation  of  our  product  candidates  or  our  other  potential  products  or  the
associated quality systems for compliance with the regulations applicable to the activities being conducted. Although we
oversee the contract manufacturers, we cannot control the manufacturing process of, and are completely dependent on, our
contract  manufacturing  partners  for  compliance  with  the  regulatory  requirements.  If  these  facilities  do  not  pass  a  pre-
approval plant inspection, regulatory approval of the products may not be granted or may be substantially delayed until any
violations  are  corrected  to  the  satisfaction  of  the  regulatory  authority,  if  ever.  In  addition,  we  have  no  control  over  the
ability of our contract manufacturers to maintain adequate quality control, quality assurance and qualified personnel.

The  regulatory  authorities  also  may,  at  any  time  following  approval  of  a  product  for  sale,  audit  the  manufacturing
facilities  of  our  third-party  contractors.  If  any  such  inspection  or  audit  identifies  a  failure  to  comply  with  applicable
regulations or if a violation of our product specifications or applicable regulations occurs independent of such an inspection
or audit, we or the relevant regulatory authority may require remedial measures that may be costly and/or time consuming
for us or a third party to implement, and that may include the temporary or permanent suspension of a clinical study or
commercial  sales  or  the  temporary  or  permanent  suspension  of  production  or  closure  of  a  facility.  Any  such  remedial
measures imposed upon us or third parties with whom we contract could materially harm our business.

If  we  or  any  of  our  third-party  manufacturers  fail  to  maintain  regulatory  compliance,  the  FDA  or  other  applicable
regulatory  authority  can  impose  regulatory  sanctions  including,  among  other  things,  refusal  to  approve  a  pending
application  for  a  new  drug  product,  withdrawal  of  an  approval,  or  suspension  of  production.  As  a  result,  our  business,
financial condition, and results of operations may be materially harmed.

Additionally, if supply from one approved manufacturer is interrupted, an alternative manufacturer would need to be
qualified through an NDA, a supplemental NDA or equivalent foreign regulatory filing, which could result in further delay.
The  regulatory  agencies  may  also  require  additional  studies  if  a  new  manufacturer  is  relied  upon  for  commercial
production. Switching manufacturers may involve substantial costs and is likely to result in a delay in our desired clinical
and commercial timelines.

These  factors  could  cause  us  to  incur  higher  costs  and  could  cause  the  delay  or  termination  of  clinical  studies,
regulatory submissions, required approvals, or commercialization of our product candidates. Furthermore, if our suppliers
fail to meet contractual requirements and we are unable to secure one or more replacement suppliers capable of production
at a substantially equivalent cost, our clinical studies may be delayed or we could lose potential revenue.

If we fail to comply or are found to have failed to comply with FDA and other regulations related to the promotion of
our products for unapproved uses, we could be subject to criminal penalties, substantial fines or other sanctions and
damage awards.

The  regulations  relating  to  the  promotion  of  products  for  unapproved  uses  are  complex  and  subject  to  substantial

interpretation by the FDA and other government agencies. If tenapanor or our other product candidates receive marketing

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approval, we and our collaboration partners, if any, will be restricted from marketing the product outside of its approved
labeling, also referred to as off-label promotion. However, physicians may nevertheless prescribe an approved product to
their  patients  in  a  manner  that  is  inconsistent  with  the  approved  label,  which  is  an  off-label  use.  We  are  implementing
compliance  and  training  programs  designed  to  ensure  that  our  sales  and  marketing  practices  comply  with  applicable
regulations regarding off-label promotion. Notwithstanding these programs, the FDA or other government agencies may
allege or find that our practices constitute prohibited promotion of our product candidates for unapproved uses. We also
cannot be sure that our employees will comply with company policies and applicable regulations regarding the promotion
of products for unapproved uses.

Over the past several years, a significant number of pharmaceutical and biotechnology companies have been the target
of  inquiries  and  investigations  by  various  federal  and  state  regulatory,  investigative,  prosecutorial  and  administrative
entities  in  connection  with  the  promotion  of  products  for  unapproved  uses  and  other  sales  practices,  including  the
Department of Justice and various U.S. Attorneys’ Offices, the Office of Inspector General of the Department of Health
and  Human  Services,  the  FDA,  the  Federal  Trade  Commission  and  various  state  Attorneys  General  offices.  These
investigations have alleged violations of various federal and state laws and regulations, including claims asserting antitrust
violations, violations of the FFDCA, the False Claims Act, the Prescription Drug Marketing Act, anti-kickback laws, and
other alleged violations in connection with the promotion of products for unapproved uses, pricing and Medicare and/or
Medicaid reimbursement. Many of these investigations originate as “qui tam” actions under the False Claims Act. Under
the False Claims Act, any individual can bring a claim on behalf of the government alleging that a person or entity has
presented a false claim, or caused a false claim to be submitted, to the government for payment. The person bringing a qui
tam suit is entitled to a share of any recovery or settlement. Qui tam suits, also commonly referred to as “whistleblower
suits,”  are  often  brought  by  current  or  former  employees.  In  a  qui  tam  suit,  the  government  must  decide  whether  to
intervene and prosecute the case. If it declines, the individual may pursue the case alone.

If the FDA or any other governmental agency initiates an enforcement action against us or if we are the subject of a
qui tam suit and it is determined that we violated prohibitions relating to the promotion of products for unapproved uses,
we could be subject to substantial civil or criminal fines or damage awards and other sanctions such as consent decrees and
corporate  integrity  agreements  pursuant  to  which  our  activities  would  be  subject  to  ongoing  scrutiny  and  monitoring  to
ensure compliance with applicable laws and regulations. Any such fines, awards or other sanctions would have an adverse
effect on our revenue, business, financial prospects and reputation.

Tenapanor, which has been approved by the FDA for the treatment of IBS-C in adults, and/or RDX013, and our other
product  candidates,  if  approved,  may  cause  or  contribute  to  adverse  medical  events  that  we  are  required  to  report  to
regulatory agencies and if we fail to do so we could be subject to sanctions that would materially harm our business.

Some  participants  in  clinical  studies  of  tenapanor  have  reported  adverse  effects  after  being  treated  with  tenapanor,
including  diarrhea,  nausea,  flatulence,  abdominal  discomfort,  abdominal  pain,  abdominal  distention  and  changes  in
electrolytes. If we are successful in commercializing any products, FDA and foreign regulatory agency regulations require
that we report certain information about adverse medical events if those products may have caused or contributed to those
adverse  events.  The  timing  of  our  obligation  to  report  would  be  triggered  by  the  date  we  become  aware  of  the  adverse
event as well as the nature of the event. We may fail to report adverse events we become aware of within the prescribed
timeframe. We may also fail to appreciate that we have become aware of a reportable adverse event, especially if it is not
reported to us as an adverse event or if it is an adverse event that is unexpected or removed in time from the use of our
products. If we fail to comply with our reporting obligations, the FDA or a foreign regulatory agency could take action,
including criminal prosecution, the imposition of civil monetary penalties, seizure of our products or delay in approval or
clearance of future products.

Our employees, independent contractors, principal investigators, CROs, collaboration partners, consultants and vendors
may  engage  in  misconduct  or  other  improper  activities,  including  noncompliance  with  regulatory  standards  and
requirements.

We are exposed to the risk that our employees, independent contractors, principal investigators, CROs, collaboration
partners, consultants and vendors may engage in fraudulent conduct or other illegal activity. Misconduct by these parties
could include intentional, reckless and/or negligent conduct or unauthorized activities that violate any of the following:

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FDA  regulations,  including  those  laws  that  require  the  reporting  of  true,  complete  and  accurate  financial  and  other
information  to  the  FDA;  manufacturing  standards;  or  federal  and  state  healthcare  fraud  and  abuse  laws  and  regulations.
Specifically,  sales,  marketing  and  business  arrangements  in  the  healthcare  industry  are  subject  to  extensive  laws  and
regulations intended to prevent fraud, kickbacks, self-dealing and other abusive practices. These laws and regulations may
restrict or prohibit a wide range of pricing, discounting, marketing and promotion, sales commission, customer incentive
programs and other business arrangements. These activities also include the improper use of information obtained in the
course  of  clinical  trials,  which  could  result  in  regulatory  sanctions  and  serious  harm  to  our  reputation.  It  is  not  always
possible to identify and deter misconduct by employees and other third parties, and the precautions we take to detect and
prevent this activity may not be effective in controlling unknown or unmanaged risks or losses or in protecting us from
governmental investigations or other actions or lawsuits stemming from a failure to comply with such laws or regulations.
Additionally, we are subject to the risk that a person or government could allege such fraud or other misconduct, even if
none occurred. If any such actions are instituted against us, and we are not successful in defending ourselves or asserting
our  rights,  those  actions  could  have  a  significant  impact  on  our  business,  including  the  imposition  of  significant  civil,
criminal  and  administrative  penalties,  damages,  monetary  fines,  disgorgements,  possible  exclusion  from  participation  in
Medicare, Medicaid and other federal healthcare programs, individual imprisonment, other sanctions, contractual damages,
reputational harm, diminished profits and future earnings, and curtailment of our operations, any of which could adversely
affect our ability to operate our business and our results of operations.

Failure  to  obtain  regulatory  approvals  in  foreign  jurisdictions  would  prevent  us  from  marketing  our  products
internationally.

In order to market any product in the EEA (which is composed of the 27 Member States of the European Union plus
Norway, Iceland and Liechtenstein), and many other foreign jurisdictions, separate regulatory approvals are required. In the
EEA, medicinal products can only be commercialized after obtaining a Marketing Authorization (“MA”). Before the MA is
granted, the EMA or the competent authorities of the Member States of the EEA make an assessment of the risk-benefit
balance of the product on the basis of scientific criteria concerning its quality, safety and efficacy.

The  approval  procedures  vary  among  countries  and  can  involve  additional  clinical  testing,  and  the  time  required  to
obtain approval may differ from that required to obtain FDA approval. Clinical trials conducted in one country may not be
accepted  by  regulatory  authorities  in  other  countries.  Approval  by  the  FDA  does  not  ensure  approval  by  regulatory
authorities  in  other  countries,  and  approval  by  one  or  more  foreign  regulatory  authorities  does  not  ensure  approval  by
regulatory  authorities  in  other  foreign  countries  or  by  the  FDA.  However,  a  failure  or  delay  in  obtaining  regulatory
approval in one country may have a negative effect on the regulatory process in others. The foreign regulatory approval
process  may  include  all  of  the  risks  associated  with  obtaining  FDA  approval.  We  may  not  be  able  to  file  for  regulatory
approvals or to do so on a timely basis, and even if we do file we may not receive necessary approvals to commercialize
our products in any market.

We and our collaboration partners may be subject to healthcare laws, regulation and enforcement; our failure or the
failure of any such collaboration partners to comply with these laws could have a material adverse effect on our results
of operations and financial conditions.

Although we do not currently have any products on the market, once we begin commercializing our products, we and
our collaboration partners may be subject to additional healthcare statutory and regulatory requirements and enforcement
by the federal government and the states and foreign governments in which we conduct our business. The laws that may
affect our ability to operate as a commercial organization include:

● the  federal  Anti-Kickback  Statute,  which  prohibits,  among  other  things,  persons  from  knowingly  and  willfully
soliciting, receiving, offering or paying remuneration, directly or indirectly, in exchange for or to induce either the
referral of an individual for, or the purchase, order or recommendation of, any good or service for which payment
may be made under federal healthcare programs such as the Medicare and Medicaid programs. A person or entity
does not need to have actual knowledge of this statute or specific intent to violate it in order to have committed a
violation;

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● federal false claims laws which prohibit, among other things, individuals or entities from knowingly presenting,
or causing to be presented, claims for payment from Medicare, Medicaid, or other third-party payors that are false
or  fraudulent.  In  addition,  the  government  may  assert  that  a  claim  including  items  or  services  resulting  from  a
violation  of  the  federal  Anti-Kickback  Statute  constitutes  a  false  or  fraudulent  claim  for  purposes  of  the  false
claims statutes;

● the  federal  Civil  Monetary  Penalties  law,  which  prohibits,  among  other  things,  offering  or  transferring
remuneration  to  a  federal  healthcare  beneficiary  that  a  person  knows  or  should  know  is  likely  to  influence  the
beneficiary’s  decision  to  order  or  receive  items  or  services  reimbursable  by  the  government  from  a  particular
provider or supplier;

● federal criminal laws that prohibit executing a scheme to defraud any healthcare benefit program or making false
statements relating to healthcare matters. Similar to the federal Anti-Kickback Statute, a person or entity does not
need to have actual knowledge of these statutes or specific intent to violate them in order to have committed a
violation;

● the  federal  physician  sunshine  requirements  under  the  ACA,  which  requires  manufacturers  of  drugs,  devices,
biologics, and medical supplies to report annually to CMS information related to payments and other transfers of
value to physicians, certain other healthcare providers beginning in 2022, and teaching hospitals, and ownership
and investment interests held by physicians and other healthcare providers and their immediate family members;

● state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws which may

apply to items or services reimbursed by any third-party payor, including commercial insurers;

● state  laws  that  require  pharmaceutical  companies  to  comply  with  the  pharmaceutical  industry’s  voluntary
compliance  guidelines  and  the  applicable  compliance  guidance  promulgated  by  the  federal  government,  or
otherwise restrict payments that may be made to healthcare providers and other potential referral sources;

● state laws that require drug manufacturers to report information related to payments and other transfers of value

to physicians and other healthcare providers or pricing information and marketing expenditures; and

● European  and  other  foreign  law  equivalents  of  each  of  the  laws,  including  reporting  requirements  detailing

interactions with and payments to healthcare providers.

Because of the breadth of these laws and the narrowness of the statutory exceptions and safe harbors available, it is
possible that some of our business activities could be subject to challenge under one or more of such laws. The risk of our
being found in violation of these laws is increased by the fact that many of them have not been fully interpreted by the
regulatory authorities or the courts, and their provisions are open to a variety of interpretations. Any action against us for
violation of these laws, even if we successfully defend against it, could cause us to incur significant legal expenses and
divert our management’s attention from the operation of our business. If our operations are found to be in violation of any
of  the  laws  described  above  or  any  other  governmental  laws  and  regulations  that  apply  to  us,  we  may  be  subject  to
penalties,  including  civil  and  criminal  penalties,  damages,  fines,  the  curtailment  or  restructuring  of  our  operations,  the
exclusion  from  participation  in  federal  and  state  healthcare  programs  and  imprisonment,  any  of  which  could  adversely
affect our ability to market our products and adversely impact our financial results.

Legislative or regulatory healthcare reforms in the United States may make it more difficult and costly for us to obtain
regulatory  clearance  or  approval  of  our  product  candidates  and  to  produce,  market  and  distribute  our  products  after
clearance or approval is obtained.

From  time  to  time,  legislation  is  drafted  and  introduced  in  Congress  that  could  significantly  change  the  statutory
provisions  governing  the  regulatory  clearance  or  approval,  manufacture,  and  marketing  of  regulated  products  or  the
reimbursement thereof. In addition, FDA regulations and guidance are often revised or reinterpreted by the FDA in ways

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that  may  significantly  affect  our  business  and  our  products.  Any  new  regulations  or  revisions  or  reinterpretations  of
existing regulations may impose additional costs or lengthen review times of our product candidates. We cannot determine
what effect changes in regulations, statutes, legal interpretation or policies, when and if promulgated, enacted or adopted
may have on our business in the future. Such changes could, among other things, require:

● additional clinical trials to be conducted prior to obtaining approval;

● changes to manufacturing methods;

● recall, replacement, or discontinuance of one or more of our products; and

● additional record keeping.

Each of these would likely entail substantial time and cost and could materially harm our business and our financial
results.  In  addition,  delays  in  receipt  of  or  failure  to  receive  regulatory  clearances  or  approvals  for  any  future  products
would harm our business, financial condition and results of operations.

In addition, the full impact of recent healthcare reform and other changes in the healthcare industry and in healthcare
spending is currently unknown, and may adversely affect our business model. In the United States, the ACA was enacted in
2010  with  a  goal  of  reducing  the  cost  of  healthcare  and  substantially  changing  the  way  healthcare  is  financed  by  both
government  and  private  insurers.  The  ACA,  among  other  things,  increased  the  minimum  Medicaid  rebates  owed  by
manufacturers  under  the  Medicaid  Drug  Rebate  Program  and  extended  the  rebate  program  to  individuals  enrolled  in
Medicaid managed care organizations, established annual fees and taxes on manufacturers of certain branded prescription
drugs, and created a new Medicare Part D coverage gap discount program, in which manufacturers must now agree to offer
70% point-of-sale discounts off negotiated prices of applicable brand drugs to eligible beneficiaries during their coverage
gap period as a condition for the manufacturer’s outpatient drugs to be covered under Medicare Part D.

Since its enactment, there have been judicial, executive and Congressional challenges to certain aspects of the ACA.
By way of example, the Tax Cuts and Jobs Act of 2017 included a provision repealing, the tax-based shared responsibility
payment imposed by the ACA on certain individuals who fail to maintain qualifying health coverage for all or part of a
year that is commonly referred to as the “individual mandate.” On December 14, 2018, a U.S. District Court Judge in the
Northern District of Texas, ruled that the individual mandate is a critical and inseverable feature of the ACA, and therefore,
because it was repealed as part of the Tax Cuts and Jobs Act, the remaining provisions of the ACA are invalid as well. On
December 18, 2019, the U.S. Court of Appeals for the 5th Circuit upheld the District Court's decision that the individual
mandate  was  unconstitutional  but  remanded  the  case  back  to  the  District  Court  to  determine  whether  the  remaining
provisions of the ACA are invalid as well. The U.S. Supreme Court is currently reviewing the case, although it is unclear
how the Supreme Court will rule. It is also unclear how other efforts, if any, to challenge, repeal, or replace the ACA will
impact  the  ACA  or  our  business.  We  cannot  predict  the  reform  initiatives  that  may  be  adopted  in  the  future  or  whether
initiatives  that  have  been  adopted  will  be  repealed  or  modified.  The  continuing  efforts  of  the  government,  insurance
companies,  managed  care  organizations  and  other  payors  of  healthcare  services  to  contain  or  reduce  costs  of  healthcare
may adversely affect the demand for any drug products for which we may obtain regulatory approval, our ability to set a
price that we believe is fair for our products, our ability to obtain coverage and reimbursement approval for a product, our
ability to generate revenues and achieve or maintain profitability, and the level of taxes that we are required to pay.

Other legislative changes have been proposed and adopted in the United States since the ACA was enacted. These new
laws, among other things, included aggregate reductions of Medicare payments of 2% per fiscal year to providers that will
remain in effect through 2030, with the exception of a temporary suspension from May 1, 2020 through March 31, 2021,
unless  additional  action  is  taken  by  Congress,  additional  specific  reductions  in  Medicare  payments  to  several  types  of
providers, including hospitals, imaging centers and cancer treatment centers, and an increase in the statute of limitations
period  for  the  government  to  recover  overpayments  to  providers  from  three  to  five  years.  Additionally,  individual  states
have become increasingly active in passing legislation and implementing regulations designed to control pharmaceutical
product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access, and
to encourage importation from other countries and bulk purchasing. Recently, there has also been heightened governmental

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scrutiny over the manner in which drug manufacturers set prices for their marketed products, which has resulted in several
Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing,
review  the  relationship  between  pricing  and  manufacturer  patient  programs,  and  reform  government  program
reimbursement methodologies for drug products.

Risks Related to Intellectual Property

We  may  become  subject  to  claims  alleging  infringement  of  third  parties’  patents  or  proprietary  rights  and/or  claims
seeking to invalidate our patents, which would be costly, time consuming and, if successfully asserted against us, delay
or prevent the development and commercialization of tenapanor or our other product candidates, or prevent or delay the
continued use of our drug discovery and development platform, including APECCS.

There have been many lawsuits and other proceedings asserting infringement or misappropriation of patents and other
intellectual property rights in the pharmaceutical and biotechnology industries. There can be no assurances that we will not
be subject to claims alleging that the manufacture, use or sale of tenapanor or any other product candidates, or that the use
of  our  drug  discovery  and  development  platform,  including  APECCS,  infringes  existing  or  future  third-party  patents,  or
that  such  claims,  if  any,  will  not  be  successful.  Because  patent  applications  can  take  many  years  to  issue  and  may  be
confidential for 18 months or more after filing, and because pending patent claims can be revised before issuance, there
may be applications now pending which may later result in issued patents that may be infringed by the manufacture, use or
sale of tenapanor or other product candidates or by the use of APECCS. Moreover, we may face patent infringement claims
from non-practicing entities that have no relevant product revenue and against whom our own patent portfolio may thus
have no deterrent effect. We may be unaware of one or more issued patents that would be infringed by the manufacture,
sale or use of tenapanor or our other product candidates, or by the use of APECCS.

We may be subject to third-party patent infringement claims in the future against us or our that would cause us to incur
substantial expenses and, if successful against us, could cause us to pay substantial damages, including treble damages and
attorney’s fees if we are found to be willfully infringing a third party’s patents. We may be required to indemnify future
collaboration partners against such claims. We are not aware of any threatened or pending claims related to these matters,
but  in  the  future  litigation  may  be  necessary  to  defend  against  such  claims.  If  a  patent  infringement  suit  were  brought
against  us  we  could  be  forced  to  stop  or  delay  research,  development,  manufacturing  or  sales  of  the  product  or  product
candidate that is the subject of the suit. In addition, if a patent infringement suit were brought against us regarding the use
of aspects of our drug discovery and development platform, we could be forced to stop our use of APECCS or of other
aspects of our platform, or we could be forced to modify our processes to avoid infringement, which may not be possible at
a reasonable cost, if at all, and which could result in substantial delay in our use of our platform for the discovery of new
product candidates or potential targets. As a result of patent infringement claims, or in order to avoid potential claims, we
may choose to seek, or be required to seek, a license from the third party and would most likely be required to pay license
fees or royalties or both. These licenses may not be available on acceptable terms, or at all. Even if we were able to obtain
a  license,  we  may  be  unable  to  maintain  such  licenses  and  the  rights  may  be  nonexclusive,  which  would  give  our
competitors access to the same intellectual property. Ultimately, we could be prevented from commercializing a product, or
forced to redesign it, or to cease our use of APECCS or some other aspect of our drug discovery and development platform
or  our  business  operations  if,  as  a  result  of  actual  or  threatened  patent  infringement  claims,  we  are  unable  to  enter  into
licenses  on  acceptable  terms,  or  unable  to  maintain  such  licenses  when  granted.  Even  if  we  are  successful  in  defending
against  such  claims,  such  litigation  can  be  expensive  and  time  consuming  to  litigate  and  would  divert  management’s
attention from our core business. Any of these events could harm our business significantly.

In addition to infringement claims against us, if third parties prepare and file patent applications in the United States
that also claim technology similar or identical to ours, we may have to participate in interference or derivation proceedings
in the United States Patent and Trademark Office (the “USPTO”) to determine which party is entitled to a patent on the
disputed  invention.  We  may  also  become  involved  in  similar  opposition  proceedings  in  the  European  Patent  Office  or
similar offices in other jurisdictions regarding our intellectual property rights with respect to our products and technology.
Since patent applications are confidential for a period of time after filing, we cannot be certain that we were the first to file
any patent application related to our product candidates.

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If our intellectual property related to our product candidates is not adequate or if we are not able to protect our trade
secrets or our confidential information, we may not be able to compete effectively in our market.

We rely upon a combination of patents, trade secret protection and confidentiality agreements to protect the intellectual
property related to our product candidates, our drug discovery and development platform and our development programs.
Any  disclosure  to  or  misappropriation  by  third  parties  of  our  confidential  or  proprietary  information  could  enable
competitors to quickly duplicate or surpass our technological achievements, thus eroding our competitive position in our
market.

The strength of patents in the biotechnology and pharmaceutical field involves complex legal and scientific questions
and can be uncertain. The patent applications that we own or license may fail to result in issued patents in the United States
or  in  foreign  countries.  Additionally,  our  research  and  development  efforts  may  result  in  product  candidates  for  which
patent protection is limited or not available. Even if patents do successfully issue, third parties may challenge the validity,
enforceability or scope thereof, which may result in such patents being narrowed, invalidated or held unenforceable. For
example, U.S. patents can be challenged by any person before the new USPTO Patent Trial and Appeals Board at any time
before one year after that person is served an infringement complaint based on the patents. Patents granted by the European
Patent  Office  may  be  similarly  opposed  by  any  person  within  nine  months  from  the  publication  of  the  grant.  Similar
proceedings are available in other jurisdictions, and in the United States, Europe and other jurisdictions third parties can
raise questions of validity with a patent office even before a patent has granted. Furthermore, even if they are unchallenged,
our patents and patent applications may not adequately protect our intellectual property or prevent others from designing
around our claims. For example, a third party may develop a competitive product that provides therapeutic benefits similar
to one or more of our product candidates but has a sufficiently different composition to fall outside the scope of our patent
protection. If the breadth or strength of protection provided by the patents and patent applications we hold or pursue with
respect  to  our  product  candidates  is  successfully  challenged,  then  our  ability  to  commercialize  such  product  candidates
could be negatively affected, and we may face unexpected competition that could have a material adverse impact on our
business.  Further,  if  we  encounter  delays  in  our  clinical  trials,  the  period  of  time  during  which  we  or  our  collaboration
partners could market tenapanor or other product candidates under patent protection would be reduced.

Even where laws provide protection, costly and time-consuming litigation could be necessary to enforce and determine
the scope of our proprietary rights, and the outcome of such litigation would be uncertain. If we or one of our collaboration
partners  were  to  initiate  legal  proceedings  against  a  third  party  to  enforce  a  patent  covering  the  product  candidate,  the
defendant  could  counterclaim  that  our  patent  is  invalid  and/or  unenforceable.  In  patent  litigation  in  the  United  States,
defendant  counterclaims  alleging  invalidity  and/or  unenforceability  are  commonplace.  Grounds  for  a  validity  challenge
could be an alleged failure to meet any of several statutory requirements, including lack of novelty, obviousness or non-
enablement. Grounds for an unenforceability assertion could be an allegation that someone connected with prosecution of
the  patent  withheld  relevant  information  from  the  USPTO,  or  made  a  misleading  statement,  during  prosecution.  The
outcome  following  legal  assertions  of  invalidity  and  unenforceability  is  unpredictable.  With  respect  to  validity,  for
example, we cannot be certain that there is no invalidating prior art, of which we and the patent examiner were unaware
during  prosecution.  If  a  defendant  were  to  prevail  on  a  legal  assertion  of  invalidity  and/or  unenforceability  against  our
intellectual property related to a product candidate, we would lose at least part, and perhaps all, of the patent protection on
such product candidate. Such a loss of patent protection would have a material adverse impact on our business. Moreover,
our  competitors  could  counterclaim  that  we  infringe  their  intellectual  property,  and  some  of  our  competitors  have
substantially greater intellectual property portfolios than we do.

We also rely on trade secret protection and confidentiality agreements to protect proprietary know-how that may not be
patentable,  processes  for  which  patents  may  be  difficult  to  obtain  and/or  enforce  and  any  other  elements  of  our  drug
discovery and development processes that involve proprietary know-how, information or technology that is not covered by
patents.  Although  we  require  all  of  our  employees,  consultants,  advisors  and  any  third  parties  who  have  access  to  our
proprietary know-how, information or technology, to assign their inventions to us, and endeavor to execute confidentiality
agreements with all such parties, we cannot be certain that we have executed such agreements with all parties who may
have helped to develop our intellectual property or who had access to our proprietary information, nor can we be certain
that our agreements will not be breached by such consultants, advisors or third parties, or by our former employees. The
breach of such agreements by individuals or entities who are actively involved in the discovery and design of our potential
drug candidates, or in the development of our discovery and design platform, including APECCS, could require us to

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pursue legal action to protect our trade secrets and confidential information, which would be expensive, and the outcome of
which  would  be  unpredictable.  If  we  are  not  successful  in  prohibiting  the  continued  breach  of  such  agreements,  our
business  could  be  negatively  impacted.  We  cannot  guarantee  that  our  trade  secrets  and  other  confidential  proprietary
information will not be disclosed or that competitors will not otherwise gain access to our trade secrets or independently
develop substantially equivalent information and techniques.

Further, the laws of some foreign countries do not protect proprietary rights to the same extent or in the same manner
as  the  laws  of  the  United  States.  As  a  result,  we  may  encounter  significant  problems  in  protecting  and  defending  our
intellectual property both in the United States and abroad. If we are unable to prevent material disclosure of the intellectual
property related to our technologies to third parties, we will not be able to establish or maintain a competitive advantage in
our market, which could materially adversely affect our business, results of operations and financial condition.

If we do not obtain patent term extension in the United States under the Hatch-Waxman Act and in foreign countries
under  similar  legislation,  thereby  potentially  extending  the  term  of  marketing  exclusivity  for  our  product  candidates,
our business may be materially harmed.

Following  the  approval  by  the  FDA  for  our  NDA  to  market  tenapanor  for  IBS-C,  we  became  eligible  to  seek  and
sought patent term restoration under the Hatch-Waxman Act for one of the U.S. patents covering our approved product or
the  use  thereof.  The  Hatch-Waxman  Act  allows  a  maximum  of  one  patent  to  be  extended  per  FDA  approved  product.
Patent  term  extension  also  may  be  available  in  certain  foreign  countries  upon  regulatory  approval  of  our  product
candidates. Despite seeking patent term extension for tenapanor or other product candidates, we may not be granted patent
term  extension  either  in  the  United  States  or  in  any  foreign  country  because  of,  for  example,  failing  to  apply  within
applicable  deadlines,  failing  to  apply  prior  to  expiration  of  relevant  patents  or  otherwise  failing  to  satisfy  applicable
requirements.  Moreover,  the  term  of  extension,  as  well  as  the  scope  of  patent  protection  during  any  such  extension,
afforded by the governmental authority could be less than we request.

If  we  are  unable  to  obtain  patent  term  extension  or  restoration,  or  the  term  of  any  such  extension  is  less  than  we
request,  the  period  during  which  we  will  have  the  right  to  exclusively  market  our  product  will  be  shortened  and  our
competitors may obtain approval of competing products following our patent expiration, and our revenue could be reduced,
possibly materially.

Obtaining  and  maintaining  our  patent  protection  depends  on  compliance  with  various  procedural,  document
submission, fee payment and other requirements imposed by governmental patent agencies, and our patent protection
could be reduced or eliminated for non-compliance with these requirements.

The USPTO and various foreign patent agencies require compliance with a number of procedural, documentary, fee
payment and other provisions to maintain patent applications and issued patents. Noncompliance with these requirements
can result in abandonment or lapse of a patent or patent application, resulting in partial or complete loss of patent rights in
the relevant jurisdiction. In such an event, competitors might be able to enter the market earlier than would otherwise have
been the case.

We may not be able to enforce our intellectual property rights throughout the world.

The  laws  of  some  foreign  countries  do  not  protect  intellectual  property  rights  to  the  same  extent  as  the  laws  of  the
United  States.  Many  companies  have  encountered  significant  problems  in  protecting  and  defending  intellectual  property
rights in certain foreign jurisdictions. The legal systems of some countries, particularly developing countries, do not favor
the enforcement of patents and other intellectual property protection, especially those relating to life sciences. This could
make  it  difficult  for  us  to  stop  the  infringement  of  our  patents  or  the  misappropriation  of  our  other  intellectual  property
rights.  For  example,  many  foreign  countries  have  compulsory  licensing  laws  under  which  a  patent  owner  must  grant
licenses to third parties.

Proceedings to enforce our patent rights in foreign jurisdictions, whether or not successful, could result in substantial
costs and divert our efforts and attention from other aspects of our business. Furthermore, while we intend to protect our
intellectual property rights in our expected significant markets, we cannot ensure that we will be able to initiate or maintain

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similar  efforts  in  all  jurisdictions  in  which  we  may  wish  to  market  our  products.  Accordingly,  our  efforts  to  protect  our
intellectual  property  rights  in  such  countries  may  be  inadequate.  In  addition,  changes  in  the  law  and  legal  decisions  by
courts in the United States and foreign countries may affect our ability to obtain and enforce adequate intellectual property
protection for our technology.

We may be subject to claims that we or our employees have misappropriated the intellectual property, including know-
how or trade secrets, of a third party, or claiming ownership of what we regard as our own intellectual property.

Many of our employees, consultants and contractors were previously employed at or engaged by other biotechnology
or  pharmaceutical  companies,  including  our  competitors  or  potential  competitors.  Some  of  these  employees,  consultants
and  contractors,  executed  proprietary  rights,  non-disclosure  and  non-competition  agreements  in  connection  with  such
previous employment. Although we try to ensure that our employees, consultants and contractors do not use the intellectual
property and other proprietary information or know-how or trade secrets of others in their work for us, and do not perform
work for us that is in conflict with their obligations to another employer or any other entity, we may be subject to claims
that we or these employees, consultants and contractors have used or disclosed such intellectual property, including know-
how, trade secrets or other proprietary information. In addition, an employee, advisor or consultant who performs work for
us may have obligations to a third party that are in conflict with their obligations to us, and as a result such third party may
claim  an  ownership  interest  in  the  intellectual  property  arising  out  of  work  performed  for  us.  We  are  not  aware  of  any
threatened or pending claims related to these matters, but in the future litigation may be necessary to defend against such
claims. If we fail in defending any such claims, in addition to paying monetary damages, we may lose valuable intellectual
property rights or personnel, or access to consultants and contractors. Even if we are successful in defending against such
claims, litigation could result in substantial costs and be a distraction to management.

In  addition,  while  we  typically  require  our  employees,  consultants  and  contractors  who  may  be  involved  in  the
development  of  intellectual  property  to  execute  agreements  assigning  such  intellectual  property  to  us,  we  may  be
unsuccessful in executing such an agreement with each party who in fact develops intellectual property that we regard as
our own, which may result in claims by or against us related to the ownership of such intellectual property. If we fail in
prosecuting  or  defending  any  such  claims,  in  addition  to  paying  monetary  damages,  we  may  lose  valuable  intellectual
property  rights.  Even  if  we  are  successful  in  prosecuting  or  defending  against  such  claims,  litigation  could  result  in
substantial costs and be a distraction to our management and scientific personnel.

Risks Related to Our Common Stock

Our stock price may be volatile and our stockholders may not be able to resell shares of our common stock at or above
the price they paid.

The  trading  price  of  our  common  stock  is  highly  volatile  and  could  be  subject  to  wide  fluctuations  in  response  to
various factors, some of which are beyond our control. These factors include those discussed in this “Risk Factors” section
and others such as:

● announcements  of  regulatory  decisions  regarding  our  NDA  seeking  marketing  approval  for  tenapanor  for  the

control of serum phosphorus in CKD patients on dialysis;

● results of regulatory inspections of our facilities or those of our contract manufacturing organizations, or specific
label restrictions or patient populations for tenapanor’s use, or changes or delays in the regulatory review process;

● announcements regarding whether tenapanor, alone or with other oral only medications, will be included in the
bundled prospective payment system for the treatment of ESRD patients, and the time and manner in which such
transition is achieved;

● results from, or any delays in, our RDX013 Phase 2 clinical trial;

● announcements relating to our current or future collaboration partnerships;

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● announcements of therapeutic innovations or new products by us or our competitors;

● adverse actions taken by regulatory agencies with respect to our product label, our clinical trials, manufacturing

supply chain or sales and marketing activities;

● changes or developments in laws or regulations applicable to our approved products or our product candidates;

● the success of our testing and clinical trials;

● failure  to  meet  any  of  our  projected  timelines  or  goals  with  regard  to  the  clinical  development  and

commercialization of any of our product candidates;

● the success of our efforts to acquire or license or discover additional product candidates;

● any intellectual property infringement actions in which we may become involved;

● the success of our efforts to obtain adequate intellectual property protection for our product candidates;

● announcements concerning our competitors or the pharmaceutical industry in general;

● achievement of expected product sales and profitability;

● manufacture, supply or distribution shortages;

● actual or anticipated fluctuations in our operating results;

● FDA or other U.S. or foreign regulatory actions affecting us or our industry or other healthcare reform measures

in the United States;

● changes in financial estimates or recommendations by securities analysts;

● trading volume of our common stock;

● sales of our common stock by us, our executive officers and directors or our stockholders in the future;

● sales of debt securities and sales or licensing of assets;

● general economic and market conditions and overall fluctuations in the United States equity markets; and

● the loss of any of our key scientific or management personnel.

In  addition,  the  stock  markets  in  general,  and  the  markets  for  pharmaceutical,  biopharmaceutical  and  biotechnology
stocks in particular, have experienced extreme volatility that may have been unrelated to the operating performance of the
issuer. These broad market fluctuations may adversely affect the trading price or liquidity of our common stock. In the past,
when the market price of a stock has been volatile, holders of that stock have sometimes instituted securities class action
litigation against the issuer. If any of our stockholders were to bring such a lawsuit against us, we could incur substantial
costs  defending  the  lawsuit  and  the  attention  of  our  management  would  be  diverted  from  the  operation  of  our  business,
which  could  seriously  harm  our  financial  position.  Any  adverse  determination  in  litigation  could  also  subject  us  to
significant liabilities.

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Our principal stockholders own a significant percentage of our stock and, together with our management, will be able to
exert significant control over matters subject to stockholder approval.

Based on the number of shares outstanding as of December 31, 2020, our officers, directors and stockholders who hold
at least 5% of our stock together beneficially own approximately 43.1% of our outstanding common stock. If these officers,
directors,  and  principal  stockholders  or  a  group  of  our  principal  stockholders  act  together,  they  will  be  able  to  exert  a
significant  degree  of  influence  over  our  management  and  affairs  and  control  matters  requiring  stockholder  approval,
including the election of directors, amendments to our organizational documents, and approval of any merger, sale of assets
or other business combination transactions. The interests of this concentration of ownership may not always coincide with
our  interests  or  the  interests  of  other  stockholders.  For  instance,  officers,  directors  and  principal  stockholders,  acting
together,  could  cause  us  to  enter  into  transactions  or  agreements  that  we  would  not  otherwise  consider.  Similarly,  this
concentration of ownership may have the effect of delaying or preventing a change in control of our company otherwise
favored by our other stockholders.

Sales of a substantial number of shares of our common stock in the public market could cause our stock price to fall.

If our existing stockholders sell, or indicate an intention to sell, substantial amounts of our common stock in the public
market,  the  trading  price  of  our  common  stock  could  decline.  As  of  December  31,  2020,  we  had  approximately  93.6
million shares of common stock outstanding. Of those shares, approximately 37.8 million were held by current directors,
executive officers and stockholders owning 5% or more of our outstanding common stock.

As of December 31, 2020, 0.2 million shares of common stock issuable upon vesting of outstanding restricted stock
units and approximately 9.8 million shares of common stock issuable upon exercise of outstanding options were eligible
for sale in the public market to the extent permitted by the provisions of the applicable vesting schedules, and Rule 144 and
Rule 701 under the Securities Act. If these additional shares of common stock are issued and sold, or if it is perceived that
they will be sold, in the public market, the trading price of our common stock could decline.

If we sell shares of our common stock in future financings, stockholders may experience immediate dilution and, as a
result, our stock price may decline.

We may from time to time issue additional shares of common stock at a discount from the current trading price of our
common stock. As a result, our stockholders would experience immediate dilution upon the purchase of any shares of our
common  stock  sold  at  such  discount.  In  addition,  as  opportunities  present  themselves,  we  may  enter  into  financing  or
similar arrangements in the future, including the issuance of debt securities, preferred stock or common stock. If we issue
common stock or securities convertible into common stock, our common stockholders would experience additional dilution
and, as a result, our stock price may decline.

General Risk Factors

We incur significant costs as a result of operating as a public company, and our management will devote substantial
time  to  new  compliance  initiatives.  We  may  fail  to  comply  with  the  rules  that  apply  to  public  companies,  including
Section 404 of the Sarbanes-Oxley Act of 2002, which could result in sanctions or other penalties that would harm our
business.

We incur significant legal, accounting and other expenses as a public company, including costs resulting from public
company  reporting  obligations  under  the  Securities  Exchange  Act  of  1934,  as  amended  (the  “Exchange  Act”)  and
regulations regarding corporate governance practices. The listing requirements of The Nasdaq Global Market require that
we  satisfy  certain  corporate  governance  requirements  relating  to  director  independence,  distributing  annual  and  interim
reports,  stockholder  meetings,  approvals  and  voting,  soliciting  proxies,  conflicts  of  interest  and  a  code  of  conduct.  Our
management  and  other  personnel  will  need  to  devote  a  substantial  amount  of  time  to  ensure  that  we  comply  with  all  of
these  requirements.  Moreover,  the  reporting  requirements,  rules  and  regulations  will  increase  our  legal  and  financial
compliance costs and will make some activities more time consuming and costly. Any changes we make to comply with
these obligations may not be sufficient to allow us to satisfy our obligations as a public company on a timely basis, or at all.
These reporting requirements, rules and regulations, coupled with the increase in potential litigation exposure

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associated with being a public company, could also make it more difficult for us to attract and retain qualified persons to
serve  on  our  board  of  directors  or  board  committees  or  to  serve  as  executive  officers,  or  to  obtain  certain  types  of
insurance, including directors’ and officers’ insurance, on acceptable terms.

We  are  subject  to  Section  404  of  The  Sarbanes-Oxley  Act  of  2002  (“Section  404”)  and  the  related  rules  of  the
Securities  and  Exchange  Commission  (“SEC”)  which  require,  among  other  things,  our  management  to  report  on  the
effectiveness  of  our  internal  control  over  financial  reporting.  Our  compliance  with  Section  404  requires  that  we  incur
substantial expense and expend significant management efforts.

During  the  course  of  our  review  and  testing  of  our  internal  controls,  we  may  identify  deficiencies  and  be  unable  to
remediate them before we must provide the required reports. Furthermore, if we have a material weakness in our internal
controls over financial reporting, we may not detect errors on a timely basis and our financial statements may be materially
misstated. We or our independent registered public accounting firm may not be able to conclude on an ongoing basis that
we have effective internal control over financial reporting, which could harm our operating results, cause investors to lose
confidence in our reported financial information and cause the trading price of our stock to fall. In addition, as a public
company we are required to file accurate and timely quarterly and annual reports with the SEC under the Exchange Act.
Any failure to report our financial results on an accurate and timely basis could result in sanctions, lawsuits, delisting of
our shares from The Nasdaq Global Market or other adverse consequences that would materially harm our business.

We may be adversely affected by the global economic environment.

Our  ability  to  attract  and  retain  collaboration  partners  or  customers,  invest  in  and  grow  our  business  and  meet  our
financial obligations depends on our operating and financial performance, which, in turn, is subject to numerous factors,
including the prevailing economic conditions and financial, business and other factors beyond our control, such as the rate
of unemployment, the number of uninsured persons in the United States, presidential elections, other political influences
and  inflationary  pressures.  Our  results  of  operations  could  be  adversely  affected  by  general  conditions  in  the  global
economy and in the global financial markets. The 2008 global financial crisis caused extreme volatility and disruptions in
the capital and credit markets. We cannot anticipate all the ways in which the global economic climate and global financial
market conditions could adversely impact our business in the future.

We are exposed to risks associated with reduced profitability and the potential financial instability of our collaboration
partners  or  customers,  many  of  which  may  be  adversely  affected  by  volatile  conditions  in  the  financial  markets.  For
example,  unemployment  and  underemployment,  and  the  resultant  loss  of  insurance,  may  decrease  the  demand  for
healthcare  services  and  pharmaceuticals.  If  fewer  patients  are  seeking  medical  care  because  they  do  not  have  insurance
coverage,  our  collaboration  partners  or  customers  may  experience  reductions  in  revenues,  profitability  and/or  cash  flow
that could lead them to reduce their support of our programs or financing activities. If collaboration partners or customers
are not successful in generating sufficient revenue or are precluded from securing financing, they may not be able to pay, or
may delay payment of, accounts receivable that are owed to us. In addition, volatility in the financial markets could cause
significant fluctuations in the interest rate and currency markets. We currently do not hedge for these risks. The foregoing
events,  in  turn,  could  adversely  affect  our  financial  condition  and  liquidity.  In  addition,  if  economic  challenges  in  the
United  States  result  in  widespread  and  prolonged  unemployment,  either  regionally  or  on  a  national  basis,  or  if  certain
provisions  of  the  Patient  Protection  and  ACA,  as  amended  by  the  Health  Care  and  Education  Reconciliation  Act,
collectively known as the ACA, are repealed, a substantial number of people may become uninsured or underinsured. To
the  extent  economic  challenges  result  in  fewer  individuals  pursuing  or  being  able  to  afford  our  product  candidates  once
commercialized, our business, results of operations, financial condition and cash flows could be adversely affected.

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Provisions  in  our  charter  documents  and  under  Delaware  law  could  discourage  a  takeover  that  stockholders  may
consider favorable and may lead to entrenchment of management.

Our amended and restated certificate of incorporation and amended and restated bylaws contain provisions that could
significantly reduce the value of our shares to a potential acquirer or delay or prevent changes in control or changes in our
management without the consent of our board of directors. The provisions in our charter documents include the following:

● a  classified  board  of  directors  with  three-year  staggered  terms,  which  may  delay  the  ability  of  stockholders  to

change the membership of a majority of our board of directors;

● no cumulative voting in the election of directors, which limits the ability of minority stockholders to elect director

candidates;

● the exclusive right of our board of directors to elect a director to fill a vacancy created by the expansion of the
board of directors or the resignation, death or removal of a director, which prevents stockholders from being able
to fill vacancies on our board of directors;

● the required approval of at least two-thirds of the shares entitled to vote to remove a director for cause, and the

prohibition on removal of directors without cause;

● the ability of our board of directors to authorize the issuance of shares of preferred stock and to determine the
price  and  other  terms  of  those  shares,  including  preferences  and  voting  rights,  without  stockholder  approval,
which could be used to significantly dilute the ownership of a hostile acquirer;

● the ability of our board of directors to alter our bylaws without obtaining stockholder approval;

● the required approval of at least two-thirds of the shares entitled to vote at an election of directors to adopt, amend
or repeal our bylaws or repeal the provisions of our amended and restated certificate of incorporation regarding
the election and removal of directors;

● a prohibition on stockholder action by written consent, which forces stockholder action to be taken at an annual or

special meeting of our stockholders;

● the  requirement  that  a  special  meeting  of  stockholders  may  be  called  only  by  the  chairman  of  the  board  of
directors, the chief executive officer, the president or the board of directors, which may delay the ability of our
stockholders to force consideration of a proposal or to take action, including the removal of directors; and

● advance notice procedures that stockholders must comply with in order to nominate candidates to our board of
directors  or  to  propose  matters  to  be  acted  upon  at  a  stockholders’  meeting,  which  may  discourage  or  deter  a
potential  acquirer  from  conducting  a  solicitation  of  proxies  to  elect  the  acquirer’s  own  slate  of  directors  or
otherwise attempting to obtain control of us.

In  addition,  these  provisions  would  apply  even  if  we  were  to  receive  an  offer  that  some  stockholders  may  consider

beneficial.

We are also subject to the anti-takeover provisions contained in Section 203 of the Delaware General Corporation Law.
Under Section 203, a corporation may not, in general, engage in a business combination with any holder of 15% or more of
its capital stock unless the holder has held the stock for three years or, among other exceptions, the board of directors has
approved the transaction.

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Claims for indemnification by our directors and officers may reduce our available funds to satisfy successful third-party
claims against us and may reduce the amount of money available to us.

Our  amended  and  restated  certificate  of  incorporation  and  amended  and  restated  bylaws  provide  that  we  will

indemnify our directors and officers, in each case to the fullest extent permitted by Delaware law.

In addition, as permitted by Section 145 of the Delaware General Corporation Law, our amended and restated bylaws

and our indemnification agreements that we have entered into with our directors and officers provide that:

● We  will  indemnify  our  directors  and  officers  for  serving  us  in  those  capacities  or  for  serving  other  business
enterprises  at  our  request,  to  the  fullest  extent  permitted  by  Delaware  law.  Delaware  law  provides  that  a
corporation  may  indemnify  such  person  if  such  person  acted  in  good  faith  and  in  a  manner  such  person
reasonably believed to be in or not opposed to the best interests of the registrant and, with respect to any criminal
proceeding, had no reasonable cause to believe such person’s conduct was unlawful.

● We  may,  in  our  discretion,  indemnify  employees  and  agents  in  those  circumstances  where  indemnification  is

permitted by applicable law.

● We  are  required  to  advance  expenses,  as  incurred,  to  our  directors  and  officers  in  connection  with  defending  a
proceeding,  except  that  such  directors  or  officers  shall  undertake  to  repay  such  advances  if  it  is  ultimately
determined that such person is not entitled to indemnification.

● We  will  not  be  obligated  pursuant  to  our  amended  and  restated  bylaws  to  indemnify  a  person  with  respect  to
proceedings  initiated  by  that  person  against  us  or  our  other  indemnitees,  except  with  respect  to  proceedings
authorized by our board of directors or brought to enforce a right to indemnification.

● The rights conferred in our amended and restated bylaws are not exclusive, and we are authorized to enter into
indemnification  agreements  with  our  directors,  officers,  employees  and  agents  and  to  obtain  insurance  to
indemnify such persons.

● We  may  not  retroactively  amend  our  amended  and  restated  bylaw  provisions  to  reduce  our  indemnification

obligations to directors, officers, employees and agents.

We  do  not  currently  intend  to  pay  dividends  on  our  common  stock,  and,  consequently,  our  stockholders’  ability  to
achieve a return on their investment will depend on appreciation in the price of our common stock.

We do not currently intend to pay any cash dividends on our common stock for the foreseeable future. We currently
intend to invest our future earnings, if any, to fund our growth. Additionally, the terms of our loan and security agreements
could  restrict  our  ability  to  pay  dividends.  Therefore,  our  stockholders  are  not  likely  to  receive  any  dividends  on  our
common stock for the foreseeable future. Since we do not intend to pay dividends, our stockholders’ ability to receive a
return on their investment will depend on any future appreciation in the market value of our common stock. There is no
guarantee that our common stock will appreciate or even maintain the price at which our holders have purchased it.

The United Kingdom’s withdrawal from the European Union may have a negative effect on global economic conditions,
financial markets and our business.

Following a national referendum and enactment of legislation by the government of the United Kingdom, the United
Kingdom formally withdrew from the European Union and ratified a trade and cooperation agreement governing its future
relationship with the European Union. The agreement, which is being applied provisionally from January 1, 2021 until it is
ratified by the European Parliament and the Council of the European Union, addresses trade, economic arrangements, law
enforcement, judicial cooperation and a governance framework including procedures for dispute resolution, among other
things. Because the agreement merely sets forth a framework in many respects and will require complex additional

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bilateral negotiations between the United Kingdom and the European Union as both parties continue to work on the rules
for implementation, significant political and economic uncertainty remains about how the precise terms of the relationship
between the parties will differ from the terms before withdrawal.

These developments, or the perception that any related developments could occur, have had and may continue to have
a material adverse effect on global economic conditions and financial markets, and may significantly reduce global market
liquidity,  restrict  the  ability  of  key  market  participants  to  operate  in  certain  financial  markets  or  restrict  our  access  to
capital.  Any  of  these  factors  could  have  a  material  adverse  effect  on  our  business,  financial  condition  and  results  of
operations and reduce the price of our common stock.

ITEM 1B. UNRESOLVED STAFF COMMENTS

None.

ITEM 2. PROPERTIES

Our  headquarters  is  currently  co-located  in  Fremont,  California  and  Waltham,  Massachusetts.  The  Fremont
headquarters  consists  of  72,500  square  feet  of  leased  office  and  laboratory  space  under  a  lease  that  expires  in
September 2021. During December 2020, we entered into a new lease agreement that currently expires in June 2026 for
12,864 square feet of office space in Waltham, Massachusetts which will serve as our east coast headquarters. In addition,
we lease 3,520 square feet of additional office space at a different location in Waltham, Massachusetts, under a lease that
currently expires in September 2021, as well as 4,768 square feet of office space in Milwaukee, Wisconsin, under a lease
that expires in February 2026. We have not renewed the lease at our current Fremont headquarters location and expect to
enter into a new facility lease in Fremont, California during the first quarter of 2021.

ITEM 3. LEGAL PROCEEDINGS

From time to time, we may be involved in legal proceedings arising in the ordinary course of business. We believe that
as of December 31, 2020, there is no litigation pending that would reasonably be expected to have a material adverse effect
on our results of operations and financial condition, and no contingent liabilities were accrued as of December 31, 2020.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

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ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND
ISSUER PURCHASES OF EQUITY SECURITIES

PART II

Common Stock

On June 19, 2014, our common stock commenced trading on The Nasdaq Global Market under the symbol “ARDX”.
Prior  to  that  date,  there  was  no  public  trading  market  for  our  common  stock.  As  of  December  31,  2020,  there  were  33
holders of record of our common stock.

Dividends

We have never declared or paid cash dividends on our capital stock. We currently intend to retain any future earnings

to finance the growth and development of our business.

Recent Sales of Unregistered Securities

None.

Use of Proceeds

Not applicable.

Issuer Purchases of Equity Securities

Not applicable.

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ITEM 6. SELECTED FINANCIAL DATA

The  data  set  forth  below  is  not  necessarily  indicative  of  the  results  of  future  operations  and  should  be  read  in
conjunction  with  the  financial  statements  and  the  notes  thereto  in  Item  8  of  Part  II,  “Financial  Statements  and
Supplementary  Data,”  and  the  information  contained  in  Item  7  of  Part  II,  “Management’s  Discussion  and  Analysis  of
Financial Condition and Results of Operations.” Historical results are not necessarily indicative of future results.

Statement of Operations Data:

2020

2019

Year Ended December 31, 
2018

2017

2016

Revenues:

Collaborative development revenue
Product supply revenue
Licensing revenue
Total revenues
Operating expenses:
Cost of revenue
Research and development
General and administrative
Total operating expenses

Loss from operations
Interest expense
Other income, net

Loss before provision for income taxes
Provision for income taxes
Net loss
Net loss per common share, basic and
diluted
Shares used in computing net loss per
share - basic and diluted

(in thousands, except share and per share amounts)

$

 5,364
 1,501
 706
 7,571

$

 459
 322
 4,500
 5,281

 — $
 287
 2,320
 2,607

$

 42,000
 —
 —
 42,000

 —
 —
 —
 —

 145
 65,053
 33,153
 98,351
 (90,780)
 (5,099)
 1,568
 (94,311)
 2
 (94,313) $

 600
 71,677
 24,267
 96,544
 (91,263)
 (5,726)
 2,352
 (94,637)
 303
 (94,940) $

 466
 69,373
 23,715
 93,554
 (90,947)
 (3,534)
 3,187
 (91,294)
 4
 (91,298) $

 8,400
 75,484
 23,231
 107,115
 (65,115)
 —
 1,955
 (63,160)
 1,179
 (64,339) $

 —
 94,161
 18,734
 112,895
 (112,895)
 —
 508
 (112,387)
 —
 (112,387)

 (1.05) $

 (1.47) $

 (1.62) $

 (1.36) $

 (2.80)

$

$

$

   89,582,138

   64,478,066

   56,219,919

   47,435,331

   40,118,522

Balance Sheet Data:

2020

2019

2017

2016

As of  December 31, 
2018
(in thousands)
$  168,089
 183,332
 49,209
   (365,512)
 115,813

$  247,512
 259,782
 50,014
   (460,452)
 186,655

$  133,976
 157,903
 —
   (278,214)
 139,312

$  200,823
 213,131
 —
  (213,875)
 193,151

Cash and investments
Total assets
Loan payable, current and non-current
Accumulated deficit
Total stockholders' equity

$  188,598
 201,562
 50,788
   (554,765)
 126,112

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ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
OPERATIONS

You  should  read  the  following  discussion  and  analysis  of  our  financial  condition  and  results  of  operations  in
conjunction  with  the  section  of  this  report  entitled  “Selected  Financial  Data”  and  our  financial  statements  and  related
notes included elsewhere in this report. This discussion and other parts of this report contain forward-looking statements
that  involve  risk  and  uncertainties,  such  as  statements  of  our  plans,  objectives,  expectations and  intentions.  Our  actual
results  could  differ  materially  from  those  discussed  in  these  forward-looking  statements.  Factors  that  could  cause  or
contribute  to  such  differences  include,  but  are  not  limited  to,  those  discussed  in  the  section  of  this  report  entitled  “Risk
Factors. ” These  forward-looking  statements  speak  only  as  of  the  date  hereof.  Except  as  required  by  law,  we  assume  no
obligation to update or revise these forward-looking statements for any reason. Unless the context requires otherwise, the
terms “Ardelyx”, “Company”, “we”, “us”, and “our” refer to Ardelyx, Inc.

OVERVIEW

We are a specialized biopharmaceutical company focused on developing first-in-class medicines to improve treatment
for people with kidney and cardiorenal diseases. This includes patients with chronic kidney disease (“CKD”) on dialysis
suffering  from  elevated  serum  phosphorus,  or  hyperphosphatemia;  and  CKD  patients  and/or  heart  failure  patients  with
elevated serum potassium, or hyperkalemia. Our lead product candidate, tenapanor, is a first-in-class medicine for which
we submitted a New Drug Application (“NDA”) to the U.S. Food and Drug Administration (“FDA”) in June 2020 for the
control of serum phosphorus in adult patients with CKD on dialysis. In September 2020 the FDA accepted the filing of our
NDA and set a Prescription Drug User Fee Act (“PDUFA”) date of April 29, 2021. Tenapanor has a unique mechanism of
action and acts locally in the gut to inhibit the sodium hydrogen exchanger 3, or NHE3. This results in the tightening of the
epithelial cell junctions, thereby significantly reducing paracellular uptake of phosphate, the primary pathway of phosphate
absorption.

OUR PRODUCT PIPELINE

Tenapanor: A New Approach for The Control of Serum Phosphorus in CKD Patients on Dialysis

Our portfolio is led by the development of tenapanor, a first-in-class medicine for the control of serum phosphorus in
adult patients with CKD on dialysis. Tenapanor for the control of serum phosphorus has a unique mechanism of action and
acts locally in the gut to inhibit the sodium hydrogen exchanger 3 (“NHE3”). This results in the tightening of the epithelial
cell  junctions,  thereby  significantly  reducing  paracellular  uptake  of  phosphate,  the  primary  pathway  of  phosphate
absorption. In September 2020 we announced that the FDA accepted the filing of our NDA for tenapanor for the control of
serum  phosphorus  in  adult  patients  with  CKD  on  dialysis.  The  acceptance  of  our  NDA  represents  the  next  critical  step
toward  bringing  to  market  a  completely  new  approach  to  the  management  of  hyperphosphatemia.  The  FDA  has  set  a
PDUFA  date  of  April  29,  2021.  We  continue  to  advance  our  commercial  preparations  for  the  launch  of  tenapanor.  The
NDA is supported by three successful Phase 3 trials involving over 1,000 patients that evaluated the use of tenapanor for
the control of serum phosphorus in CKD patients on dialysis, with two trials evaluating tenapanor as monotherapy and one
trial evaluating tenapanor as part of a dual mechanism approach with binders.

We  have  established  agreements  with  Kyowa  Kirin  Co.,  Ltd.  (“KKC”)  in  Japan,  Shanghai  Fosun  Pharmaceutical
Industrial Development Co. Ltd. (“Fosun Pharma”) in China and Knight Therapeutics, Inc. (“Knight“) in Canada for the
development and commercialization of tenapanor for certain indications in their respective territories.

In December 2019, we reported statistically significant topline efficacy results from our second monotherapy Phase 3
clinical trial, the PHREEDOM trial, which evaluated tenapanor for the control of serum phosphorus in CKD patients on
dialysis. The PHREEDOM trial followed a successful monotherapy Phase 3 clinical trial completed in 2017, the BLOCK
trial,  which  achieved  statistical  significance  for  the  primary  endpoint.  The  only  adverse  event  reported  in  these  Phase  3
trials  in  less  than  5%  of  patients  was  diarrhea,  with  an  incidence  rate  of  52%  in  the  PHREEDOM  trial  and  39%  in  the
BLOCK trial, with most incidences in each trial being mild to moderate in nature. PHREEDOM is a one-year study with a
26-week open-label treatment period and a 12-week double-blind, placebo-controlled randomized withdrawal period

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followed by a 14-week open-label safety extension period. An active safety control group, for safety analysis only, received
sevelamer,  open-label,  for  the  entire  52-week  study  period.  Patients  completing  the  PHREEDOM  trial  from  both  the
tenapanor  arm  and  the  sevelamer  active  safety  control  arm  had  the  option  to  participate  in  NORMALIZE,  an  ongoing
open-label 18-month extension study.

 In June 2020, we announced positive results from a planned interim data analysis from our ongoing NORMALIZE
extension  study  evaluating  tenapanor,  as  monotherapy  or  in  combination  with  sevelamer,  to  achieve  serum  phosphorus
levels in the normal range (2.5 – 4.5 mg/dL) in patients with CKD on dialysis. The NORMALIZE extension study allowed
patients from our PHREEDOM study to continue therapy with tenapanor and enabled those patients in the PHREEDOM
safety  control  arm  receiving  sevelamer  carbonate  to  transition  to  tenapanor.  The  data  from  the  planned  interim  analysis
demonstrated that the foundational use of tenapanor as monotherapy or in combination with sevelamer carbonate produces
a significant phosphorus-lowering effect with a mean serum phosphorous reduction of 2. 33 mg/dL, from a mean baseline
phosphorus of 7. 27 mg/dL at the beginning of the PHREEDOM trial to a mean of 4. 94 mg/dL at the time of this analysis.
Of the 171 patients in this interim analysis who completed up to 9 months of treatment in this extension study, up to 47. 4%
achieved a normal serum phosphorus level, and of those, the majority were on tenapanor alone or tenapanor with low dose
sevelamer of three or fewer sevelamer tablets per day. These data represent a 58% improvement in the rate of patients who
achieve  a  normal  serum  phosphorus  level,  as  compared  to  current  treatment  practice  data  as  reported  in  the  April  2020
Dialysis Outcomes Practice Patterns Study (“DOPPS”) Practice Monitor. The DOPPS data demonstrate that, with currently
available  treatments,  only  30%  of  patients  have  serum  phosphorous  levels  less  than  4.6  mg/dL.  The  only  adverse  event
reported in greater than 5% of patients in NORMALIZE was diarrhea, with an incidence rate of 23.3%.

In  September  2019,  we  reported  positive  results  from  the  AMPLIFY  trial,  a  Phase  3  study  evaluating  tenapanor  in
patients with CKD on dialysis who had uncontrolled hyperphosphatemia despite phosphate binder treatment. In this trial,
approximately  twice  the  number  of  patients  achieved  the  serum  phosphorus  treatment  goal  of  less  than  5.5  mg/dL  with
tenapanor  and  phosphate  binders  versus  phosphate  binders  alone.  The  only  adverse  event  with  a  placebo-adjusted  rate
greater than 3% was diarrhea, with an incidence rate of 43%, with most being mild to moderate in nature.

In June 2020, our partner Kyowa Kirin Co., Ltd., a Japan-based global specialty pharmaceutical company exclusively
developing  tenapanor  in  Japan,  presented  results  from  a  Phase  2  trial  of  tenapanor  at  the  European  Renal  Association-
European Dialysis and Transplant Association annual meeting (“ERA-EDTA 2020”). The trial was designed to evaluate if,
with tenapanor, patients with hyperphosphatemia undergoing hemodialysis could achieve at least a 30% decrease in mean
pill  burden  while  maintaining  their  serum  phosphorus  level.  The  study  results  were  statistically  significant,  with  71.6%
(p<0.001)  of  patients  achieving  at  least  a  30%  reduction  in  mean  pill  burden.  The  overall  mean  reduction  in  phosphate
binder usage was 80% (reduction from 14.7 to 3.0 pills per day), while maintaining serum phosphorus control. The mean
phosphorus level of patients entering the study on treatment with binders was 5.2 mg/dL at baseline and 4.7 mg/dL at the
end of the 26-week study.

Tenapanor, if approved, would be the first therapy for phosphate management that blocks phosphorus absorption at the
primary pathway of uptake. It is not a phosphate binder. Tenapanor is a novel, potent, small molecule, that has been shown
in phase 3 studies to treat hyperphosphatemia as monotherapy and as a dual mechanism approach.

IBSRELA® (tenapanor) for Irritable Bowel Syndrome with Constipation (IBS-C)

In addition to the development of tenapanor for hyperphosphatemia, we have developed tenapanor for the treatment of
patients  with  irritable  bowel  syndrome  with  constipation  (“IBS-C”).  In  September  2019,  we  received  FDA  approval  of
IBSRELA® (tenapanor) for the treatment of IBS-C in adults. IBS-C is a burdensome gastrointestinal (“GI”) disorder. It is
characterized by significant abdominal pain, constipation, straining during bowel movements, bloating and/or gas.

RDX013 Program: Small Molecule for Treating Hyperkalemia

We  are  also  advancing  a  small  molecule  potassium  secretagogue  program,  RDX013,  for  the  potential  treatment  of
hyperkalemia. Hyperkalemia is a common problem in patients with heart and kidney disease, particularly in patients taking
common blood pressure medications known as renin-angiotensin-aldosterone system (“RAAS”) inhibitors. Similar to what
we have done with tenapanor in developing a non-binder approach for the treatment of elevated serum phosphate levels,

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RDX013 is designed to target the underlying biological mechanisms of potassium secretion to lower elevated potassium.
While currently available therapies are all ion exchange agents, RDX013 is a first in class approach that exerts its effects
by amplifying the underlying pathways of potassium secretion in the colon.

Since commencing operations in October 2007, substantially all our efforts have been dedicated to our research and
development  (“R&D”)  activities,  including  developing  our  clinical  product  candidate  tenapanor  and  developing  our
proprietary drug discovery and design platform. We have not generated any revenues from product sales. As of December
31, 2020, we had an accumulated deficit of $554.8 million.

We  expect  to  continue  to  incur  substantial  operating  losses  for  the  foreseeable  future  as  a  result  of  costs  associated
with the following activities: our continued development of tenapanor for the control of serum phosphorus in CKD patients
on dialysis; our preparations for, and if approved, the commercialization of tenapanor in the United States for the control of
serum  phosphorus  in  CKD  patients  on  dialysis,  including  significantly  increased  personnel  costs  associated  with  our
commercial team; the performance of certain activities required as a result of our NDA approval of tenapanor for IBS-C;
the continued development of RDX013 and the advancement of our research programs into the preclinical stage. To date,
we have funded our operations from the sale and issuance of common stock and convertible preferred stock, funds from
our collaboration partnerships, which includes license fees, milestones and product supply revenue, as well as funds from
our Loan Agreement with Solar Capital Ltd. and Western Alliance Bank.

RDX020 Program:  Small molecule for Treating Metabolic Acidosis

We have an ongoing discovery program targeting the inhibition of bicarbonate exchange inhibitor for the treatment of
metabolic acidosis, a highly prevalent comorbidity in CKD patients that is strongly correlated with disease progression and
adverse outcomes. We have identified lead compounds that are potent, selective and proprietary inhibitors of bicarbonate
secretion.

FINANCIAL OPERATIONS OVERVIEW

Revenue

Our revenue to date has been generated primarily through license, research and development collaborative agreements
with various collaboration partners. We have not generated any revenue from commercial product sales. In the future, we
may generate revenue from a combination of our own product sales, if regulatory approval is received, and payments in
connection with our current or future collaborative partnerships, including license fees, other upfront payments, milestone
payments,  royalties  and  payments  for  drug  product  and/or  drug  substance.  We  expect  that  any  revenue  we  generate  will
fluctuate in future periods as a result of, among other factors: whether we receive regulatory approval for tenapanor for the
control of serum phosphorus in CDK patients on dialysis, and if such approval is received, the timing of such approval and
the extent to which we are successful in our efforts to commercialize tenapanor for such indication; the timing and progress
of  goods  and  services  provided  pursuant  to  our  current  or  future  collaborative  partnerships;  our  or  our  collaborators’
achievement  of  preclinical,  clinical,  regulatory  or  commercialization  milestones,  to  the  extent  achieved;  the  timing  and
amount  of  any  payments  to  us  relating  to  the  aforementioned  milestones;  and  the  extent  to  which  any  of  our  product
candidates  are  approved  and  successfully  commercialized  by  a  collaboration  partner.  If  we,  our  current  collaboration
partners or any future collaboration partners fail to obtain regulatory approval for tenapanor, our ability to generate future
revenue from our product sales or from our collaborative arrangements, and our results of operations and financial position,
would  be  materially  and  adversely  affected.  Our  past  revenue  performance  is  not  necessarily  indicative  of  results  to  be
expected  in  future  periods.  See  Note  2,  Summary  of  Significant  Accounting  Policies,  in  the  notes  to  our  financial
statements, included in Part II, Item 8, of this Annual Report on Form 10-K, for further details.

Cost of Revenue

Cost of revenue currently represents payments due to AstraZeneca, which under the terms of a termination agreement
entered into in 2015 is entitled to (i) future royalties at a rate of 10% of net sales of tenapanor or other NHE3 products by
us or our licensees, and (ii) 20% of non-royalty revenue received from our collaboration partners to which we provide

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rights to develop and commercialize tenapanor or certain other NHE3 inhibitors. We have agreed to pay AstraZeneca up to
a  maximum  of  $75.0  million  in  the  aggregate  for  (i)  and  (ii).  We  recognize  these  expenses  as  cost  of  revenue  when  we
recognize the corresponding revenue that gives rise to payments due to AstraZeneca. To date, we recognized an aggregate
of $10.6 million as cost of revenue under the AZ Termination Agreement since 2017. See details in Note 12, Collaboration
and Licensing Agreements, under AstraZeneca, in the notes to our financial statements, included in Part II, Item 8, of this
Annual Report on Form 10-K.

Research and Development

We  recognize  all  research  and  development  expenses  as  they  are  incurred  to  support  the  discovery,  research,
development  and  manufacturing  of  our  product  candidates.  Research  and  development  expenses  include,  but  are  not
limited to, the following:

● external  research  and  development  expenses  incurred  under  agreements  with  consultants,  third-party  contract
research  organizations  (“CROs”)  and  investigative  sites  where  a  substantial  portion  of  our  clinical  studies  are
conducted, and with contract manufacturing organizations where our clinical supplies are produced;

● expenses associated with supplies and materials consumed in connection with our research operations;

● expenses associated with producing tenapanor for the control of serum phosphorus in adult patients with CKD on

dialysis prior to FDA approval;

● other costs associated with research, clinical development and regulatory activities; and

● employee-related expenses, which include salaries, bonuses, benefits, travel and stock-based compensation;

● facilities and other allocated expenses, which include direct and allocated expenses for rent and maintenance of

facilities, depreciation and amortization expense, information technology expense and other supplies.

We expect to continue to make substantial investments in research and development activities as we further progress
the development of tenapanor, RDX013 and our other product candidates as we advance our research programs into the
preclinical  stage  and  as  we  continue  our  early  stage  research.  The  process  of  conducting  preclinical  studies  and  clinical
trials necessary to obtain regulatory approval is costly and time-consuming. We may not succeed in achieving marketing
approval for our product candidates, including tenapanor for the control of serum phosphorus in adult patients with CKD
on dialysis. The probability of success of each of the product candidates may be affected by numerous factors, including
preclinical data, clinical data, the regulatory process, market acceptance, sufficient third-party coverage or reimbursement,
our ability to access capital on acceptable terms, competition, manufacturing capability and commercial viability.

We anticipate that we will make determinations as to which programs to pursue and how much funding to direct to
each  program  on  an  ongoing  basis  in  response  to  the  scientific  and  clinical  success  of  each  product  candidate,  ongoing
assessment as to each product candidate’s commercial potential, and our ability to access capital on acceptable terms. We
will need to raise additional capital to complete the development and commercialization of tenapanor. If we are unable to
access capital on a timely basis and on terms that are acceptable to us, we may be forced to restructure certain aspects of
our  business  or  identify  and  complete  one  or  more  strategic  collaborations  or  other  transactions  in  order  to  fund  the
development or commercialization of tenapanor, the development of RDX013 or certain of our product candidates through
the use of alternative structures.

General and Administrative

General  and  administrative  expenses  consist  primarily  of  salaries  and  related  benefits,  including  stock-based
compensation,  for  certain  of  our  executives,  our  board  members,  and  our  finance,  legal,  business  development,  market
development, commercial and support staff. Other general and administrative expenses include facility related costs and

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professional fees for legal, accounting and audit, investor relations, other consulting services and allocated facility related
costs not otherwise included in research and development expenses.

We anticipate that our general and administrative expenses will increase in the future primarily because of increased
pre-commercial and commercial activities, personnel costs and professional fees for services to support the potential launch
and commercialization of tenapanor for the control of serum phosphorus in adult patients with CKD on dialysis.

Interest Expense

Interest expense represents the interest paid on our loan payable.

Other Income, net

Other  income,  net  consists  of  interest  income  earned  on  our  cash  and  cash  equivalents  and  held-to-maturity

investments, the periodic revaluation of the exit fee related to our loan and currency exchange gains and losses.

Provision for Income Taxes

Our  provision  for  income  taxes  includes  current  and  deferred  tax,  including  foreign  withholding  taxes  paid  on
payments  received  from  certain  collaboration  partners.  Deferred  income  taxes  reflect  the  tax  effects  of  temporary
differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for
income tax purposes. Our deferred tax assets continue to be fully offset by a valuation allowance, including deferred tax
assets related to our net operating loss carryforwards, which may be subject to annual limitations as a result of ownership
changes that may have occurred or could occur in the future.

CRITICAL ACCOUNTING POLICES AND ESTIMATES

A  detailed  discussion  of  our  significant  accounting  policies  can  be  found  in  Note  2,  Summary  of  Significant
Accounting Policies, in the notes to our financial statements, included in Part II, Item 8, of this Annual Report on Form 10-
K. Critical accounting policies are those that require significant judgment and/or estimates by management at the time that
financial statements are prepared such that materially different results might have been reported if other assumptions had
been made. These estimates form the basis for making judgments about the carrying values of assets and liabilities. We
base  our  estimates  and  judgments  on  historical  experience  and  on  various  other  assumptions  that  we  believe  to  be
reasonable under the circumstances. Actual results could differ materially from these estimates.

We  consider  certain  accounting  policies  related  to  revenue  recognition,  accrued  research  and  development  expenses
and stock-based compensation to be critical policies to understanding the judgments and estimates applied in our reported
financial results.

Revenue Recognition

We  generate  revenue  primarily  from  research  and  collaboration  and  license  agreements  with  customers.  Goods  and
services  in  the  agreements  may  include  the  grant  of  licenses  for  the  use  of  our  technology,  the  provision  of  services
associated  with  the  research  and  development  of  product  candidates,  manufacturing  services,  and  participation  in  joint
steering  committees.  The  terms  of  these  arrangements  typically  include  payment  to  us  of  one  or  more  of  the  following:
non-refundable,  up-front  license  fees;  research,  development,  regulatory  and  commercial  milestone  payments;
reimbursement  of  research  and  development  services;  option  payments;  reimbursement  of  certain  costs;  payments  for
manufacturing supply services; and future royalties on net sales of licensed products.

When  two  or  more  contracts  are  entered  into  with  the  same  customer  at  or  near  the  same  time,  we  evaluate  the
contracts to determine whether the contracts should be accounted for as a single arrangement. Contracts are combined and
accounted for as a single arrangement if one or more of the following criteria are met: (i) the contracts are negotiated as a
package

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with  a  single  commercial  objective;  (ii)  the  amount  of  consideration  to  be  paid  in  one  contract  depends  on  the  price  or
performance  of  the  other  contract;  or  (iii)  the  goods  or  services  promised  in  the  contracts  (or  some  goods  or  services
promised in each of the contracts) are a single performance obligation.

 In  determining  the  appropriate  amount  of  revenue  to  be  recognized  as  we  fulfill  our  obligations  under  each  of  our
agreements, management performs the following steps: (i) identification of the promised goods or services in the contract;
(ii)  determination  of  whether  the  promised  goods  or  services  are  performance  obligations  including  whether  they  are
distinct  in  the  context  of  the  contract;  (iii)  measurement  of  the  transaction  price,  including  any  constraints  on  variable
consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when
(or  as)  we  satisfy  each  performance  obligation.  As  part  of  the  accounting  for  contracts  with  customers,  we  develop
assumptions  that  require  judgment  to  determine  whether  promised  goods  and  services  represent  distinct  performance
obligations and the standalone selling price for each performance obligation identified in the contract. This evaluation is
subjective and requires us to make judgments about the promised goods and services and whether those goods and services
are  separable  from  other  aspects  of  the  contract.  Further,  determining  the  standalone  selling  price  for  performance
obligations  requires  significant  judgment,  and  when  an  observable  price  of  a  promised  good  or  service  is  not  readily
available,  we  consider  relevant  assumptions  to  estimate  the  standalone  selling  price,  including,  as  applicable,  market
conditions,  development  timelines,  probabilities  of  technical  and  regulatory  success,  reimbursement  rates  for  personnel
costs, forecasted revenues, potential limitations to the selling price of the product and discount rates.

We apply judgment in determining whether a combined performance obligation is satisfied at a point in time or over
time,  and,  if  over  time,  concluding  upon  the  appropriate  method  of  measuring  progress  to  be  applied  for  purposes  of
recognizing revenue. We evaluate the measure of progress each reporting period and, as estimates related to the measure of
progress  change,  related  revenue  recognition  is  adjusted  accordingly.  Changes  in  our  estimated  measure  of  progress  are
accounted  for  prospectively  as  a  change  in  accounting  estimate.  We  recognize  collaboration  revenue  by  measuring  the
progress toward complete satisfaction of the performance obligation using an input measure. In order to recognize revenue
over the research and development period, we measure actual costs incurred to date compared to the overall total expected
costs to satisfy the performance obligation. Revenues are recognized as the program costs are incurred. We will re-evaluate
the estimate of expected costs to satisfy the performance obligation each reporting period and make adjustments for any
significant changes. Amounts received prior to satisfying the revenue recognition criteria are recorded as contract liabilities
in our balance sheets. If the related performance obligation is expected to be satisfied within the next twelve months, this
will be classified in current liabilities. Amounts recognized as revenue prior to receipt are recorded as contract assets in our
balance sheets. If we expect to have an unconditional right to receive the consideration in the next twelve months, this will
be classified in current assets. A net contract asset or liability is presented for each contract with a customer.

Milestone  Payments:  At  the  inception  of  each  arrangement  that  includes  research  and  development  milestone
payments,  we  evaluate  whether  the  milestones  are  considered  probable  of  being  reached  and  estimate  the  amount  to  be
included in the transaction price using the most likely amount method. Amounts of variable consideration are included in
the  transaction  price  to  the  extent  that  it  is  probable  that  a  significant  reversal  in  the  amount  of  cumulative  revenue
recognized  will  not  occur  and  when  the  uncertainty  associated  with  the  variable  consideration  is  subsequently  resolved.
Milestone payments that are not within the control of us or the licensee, such as regulatory approvals, are not considered
probable of being achieved until those approvals are received. The transaction price is then allocated to each performance
obligation  on  a  relative  standalone  selling  price  basis,  for  which  we  recognize  revenue  as  or  when  the  performance
obligations under the contract are satisfied. At the end of each subsequent reporting period, we re-evaluate the probability
of  achievement  of  such  development  milestones  and  any  related  constraints,  and  if  necessary,  adjust  our  estimate  of  the
overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect earnings
in the period of adjustment.

Manufacturing supply services: Arrangements that include a promise for the future supply of drug substance or drug
product  for  either  clinical  development  or  commercial  supply  at  the  customer’s  discretion  are  generally  considered  as
options.  We  assess  if  these  options  provide  a  material  right  to  the  licensee  and  if  so,  they  are  accounted  for  as  separate
performance  obligations.  If  we  are  entitled  to  additional  payments  when  the  customer  exercises  these  options,  any
payments are recorded in product supply revenues when the customer obtains control of the goods, which is upon delivery.

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Royalties:  For  arrangements  that  include  sales-based  royalties,  including  milestone  payments  based  on  the  level  of
sales, and where the license is deemed to be the predominant item to which the royalties relate, we recognize revenue at the
later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has
been  allocated  has  been  satisfied  (or  partially  satisfied).  To  date,  we  have  not  recognized  any  royalty  revenue  resulting
from any of our licensing arrangements.

Licenses of intellectual property: If a license granted to a customer to use our intellectual property is determined to be
distinct  from  the  other  performance  obligations  identified  in  the  arrangement,  we  recognize  revenue  from  consideration
allocated to the license when the license is transferred to the licensee and the licensee is able to use and benefit from the
license.  For  licenses  that  are  bundled  with  other  promises,  we  apply  judgment  to  assess  the  nature  of  the  combined
performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in
time and, if over time, to conclude upon the appropriate method of measuring progress for purposes of recognizing revenue
related to consideration allocated to the performance obligation.

Options:  Customer  options,  such  as  options  granted  to  allow  a  licensee  to  choose  to  research,  develop  and
commercialize licensed compounds are evaluated at contract inception in order to determine whether those options provide
a material right (i. e. , an optional good or service offered for free or at a discount) to the customer. If the customer options
represent a material right, the material right is treated as a separate performance obligation at the outset of the arrangement.
We allocate the transaction price to material rights based on the standalone selling price, and revenue is recognized when or
as the future goods or services are transferred or when the option expires. Customer options that are not material rights do
not  give  rise  to  a  separate  performance  obligation,  and  as  such,  the  additional  consideration  that  would  result  from  a
customer  exercising  an  option  in  the  future  is  not  included  in  the  transaction  price  for  the  current  contract.  Instead,  the
option  is  deemed  a  marketing  offer,  and  additional  option  fee  payments  are  recognized  or  being  recognized  as  revenue
when  the  licensee  exercises  the  option.  The  exercise  of  an  option  that  does  not  represent  a  material  right  is  treated  as  a
separate contract for accounting purposes.

Contract modifications: Contract modifications, defined as changes in the scope or price (or both) of a contract that are
approved  by  the  parties  to  the  contract,  such  as  a  contract  amendment,  exist  when  the  parties  to  a  contract  approve  a
modification that either creates new or changes existing enforceable rights and obligations of the parties to the contract.
Depending  on  facts  and  circumstances,  we  account  for  a  contract  modification  as  one  of  the  following:  (i)  a  separate
contract; (ii) a termination of the existing contract and a creation of a new contract; or (iii) a combination of the preceding
treatments. A contract modification is accounted for as a separate contract if the scope of the contract increases because of
the  addition  of  promised  goods  or  services  that  are  distinct  and  the  price  of  the  contract  increases  by  an  amount  of
consideration  that  reflects  our  standalone  selling  prices  of  the  additional  promised  goods  or  services.  When  a  contract
modification  is  not  considered  a  separate  contract  and  the  remaining  goods  or  services  are  distinct  from  the  goods  or
services  transferred  on  or  before  the  date  of  the  contract  modification,  we  account  for  the  contract  modification  as  a
termination  of  the  existing  contract  and  a  creation  of  a  new  contract.  When  a  contract  modification  is  not  considered  a
separate contract and the remaining goods or services are not distinct, we account for the contract modification as an add-
on to the existing contract and as an adjustment to revenue on a cumulative catch-up basis.

We receive payments from our licensees as established in each contract. Upfront payments and fees are recorded as
deferred  revenue  upon  receipt  or  when  due  and  may  require  deferral  of  revenue  recognition  to  a  future  period  until  we
perform our obligations under these arrangements. Where applicable, amounts are recorded as unbilled revenue when our
right  to  consideration  is  unconditional.  We  do  not  assess  whether  a  contract  with  a  customer  has  a  significant  financing
component if the expectation at contract inception is such that the period between payment by the licensees and the transfer
of the promised goods or services to the licensees will be one year or less.

Accrued Research and Development Expenses

As part of the process of preparing our financial statements, we are required to estimate our accrued expenses. This
process involves reviewing open contracts and purchase orders, communicating with our personnel to identify services that
have been performed on our behalf and estimating the level of service performed and the associated cost incurred for the
service when we have not yet been invoiced or otherwise notified of the actual cost. The majority of our service

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providers invoice us monthly in arrears for services performed or when contractual milestones are met. We make estimates
of our accrued expenses as of each balance sheet date in our financial statements based on facts and circumstances known
to us at that time. We periodically confirm the accuracy of our estimates with the service providers and make adjustments if
necessary. Examples of estimated accrued research and development expenses include fees paid to:

● CROs in connection with clinical studies;

● investigative sites in connection with clinical studies;

● vendors related to contract manufacturing, development and distribution of clinical supplies;

● collaborator entities in connection with our collaboration agreements; and

● vendors in connection with preclinical development activities.

We record expenses related to clinical studies and manufacturing development activities based on our estimates of the
services received and efforts expended pursuant to contracts with our CROs and manufacturing vendors that conduct and
manage  these  activities  on  our  behalf.  The  financial  terms  of  these  agreements  are  subject  to  negotiation,  vary  from
contract  to  contract,  and  may  result  in  uneven  payment  flows.  There  may  be  instances  in  which  payments  made  to  our
vendors  will  exceed  the  level  of  services  provided  and  result  in  a  prepayment  of  the  expense.  Payments  under  some  of
these  contracts  depend  on  factors  such  as  the  successful  enrollment  of  subjects  and  the  completion  of  clinical  trial
milestones.  In  accruing  service  fees,  we  estimate  the  time  period  over  which  each  component  of  a  service  will  be
performed,  and  estimate,  with  vendor  input  if  appropriate,  the  resulting  level  of  completion  of  each  component  of  the
service, with such estimates often involving drivers that provide a surrogate measurement of completion such as number of
enrolled subjects and/or number of sites activated in the calculation of clinical trial fee accruals. If the actual timing of the
performance of services or the level of effort varies from our estimate, we adjust the accrued or prepaid expense balance
accordingly.  Although  we  do  not  expect  our  estimates  to  be  materially  different  from  amounts  actually  incurred,  if  our
estimates of the status and timing of services performed differ from the actual status and timing of services performed, we
may report amounts that are too high or too low in any particular period.

Stock-Based Compensation

We estimate the fair value of stock options and Employee Stock Purchase Plan (“the ESPP”) shares using the Black-
Scholes valuation model. The Black-Scholes model requires the input of highly subjective assumptions which determine
the fair value of stock-based awards. These assumptions include:

Expected  Term—We  have  limited  historical  information  to  develop  reasonable  expectations  about  future  exercise
patterns  and  post-vesting  employment  termination  behavior  for  our  stock-option  grants.  As  such,  the  expected  term  is
estimated using the simplified method whereby the expected term equals the arithmetic average of the vesting term and the
original contractual term of the option.

Expected  Volatility—  Since  January  1,  2017,  we  have  used  the  historic  volatility  of  our  own  stock  over  the
retrospective period corresponding to the expected remaining term of the options, or the period since our shares were first
quoted on The Nasdaq Global Market, if that is shorter, to compute our expected stock price volatility.

Risk-Free Interest Rate—The risk-free interest rate assumption is based on zero-coupon U.S. Treasury instruments on

the date of grant with a maturity date consistent with the expected term of our stock option grants.

Expected Dividend— To date, we have not declared or paid any cash dividends and do not have any plans to do so in

the future. Therefore, we use an expected dividend yield of zero.

As  required,  we  review  our  valuation  assumptions  at  each  grant  date  and,  as  a  result,  we  are  likely  to  change  our
valuation assumptions used to value employee stock-based awards granted in future periods. Employee and director stock-

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based  compensation  costs  are  to  be  recognized  over  the  vesting  period  of  the  award,  and  we  have  elected  to  use  the
straight-line  attribution  method.  Forfeitures  are  estimated  at  the  time  of  grant  and  revised,  if  necessary,  in  subsequent
periods if actual forfeitures differ from those estimates. We estimate forfeitures based on historical experience.

Restricted stock units, or RSUs, are measured at the fair value of our common stock on the date of grant and expensed

over the period of vesting using the straight-line attribution approach.

Performance-based RSUs, or PRSUs, are valued at grant-date fair market value. The vesting of the PRSUs is based on
performance  conditions.  Performance  conditions  include:  (i)  a  specific  performance  criteria  and  (ii)  the  employee’s
continuous employment by the company for a stated period of time in order to earn the right to the related PRSUs to vest.
The Company recognizes compensation cost with respect to the vesting of the PRSUs on a ratable basis over the requisite
service period, upon the performance conditions being deemed probable of achievement.

RESULTS OF OPERATIONS

Comparison of the Years Ended December 31, 2020 and 2019

Revenue

Below is a summary of our total revenue (dollars in thousands):

Year Ended
December 31, 

2020

2019

Collaborative development revenue
Product supply revenue

Licensing revenue
Total revenues

$

$

 5,364
 1,501

 706
 7,571

$

$

$

Change % Change
$  4,905  1,068.6 %
 366.1 %

 1,179

 459
 322

 4,500
 5,281

(3,794)
$  2,290

 (84.3)%
 43.4 %

The  increase  in  our  revenue  was  primarily  attributable  to  $4.9  million  higher  collaborative  development  revenue
recognized  in  connection  with  the  2019  KKC  Agreement,  which  was  entered  into  in  November  2019,  a  $0.7  million
licensing revenue recognized upon Knight’s achievement of a development milestone pursuant to the Knight Agreement
and a $1.4 million increase in manufacturing supply of tenapanor and other materials sold to KKC in accordance with the
2017 KKC Agreement, partially offset by $3.0 million revenue related to achievement of a milestone pursuant to the Fosun
agreement during the year ended December 31, 2019.

Operating Expenses

Below is a summary of our operating expenses (dollars in thousands):

Cost of revenue
Research and development
General administrative

Total

Year Ended December 31, 

2020

2019

$ Change

  $

 145
 65,053
 33,153
$  98,351

$

 600
 71,677
 24,267
$  96,544

$

$

 (455)
 (6,624)
 8,886
 1,807

% Change
 (75.8) %
 (9.2) %
 36.6 %
 1.9 %

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Cost of Revenue

Cost  of  revenue  was  $0.1  million  for  the  year  ended  December  31,  2020,  a  decrease  of  $0.5  million,  or  75.8%,
compared  to  $0.6  million  for  the  year  ended  December  31,  2019.  Cost  of  revenue  in  both  periods  is  the  portion  of
tenapanor-related  upfront  and  milestone  payment  from  our  collaboration  partners  that  we  are  required  to  make  to
AstraZeneca under the AstraZeneca Termination Agreement.

Research and Development

Below is a summary of our research and development expenses (dollars in thousands):

External R&D expenses
Employee-related expenses
Facilities, equipment and
depreciation expense
Other
Total

Year Ended December 31, 

2020
 37,624
 20,911

 5,738
 780
 65,053

2019
 45,989
 19,466

 5,934
 288
 71,677

$

$

$

  $

$

$

$ Change

 (8,365)
 1,445

% Change
 (18.2)%
 7.4 %

 (196)
 492
 (6,624)

 (3.3)%
 170.8 %
 (9.2)%

The decrease in our external R&D expenses for the year ended December 31, 2020 primarily includes a $9.7 million
decrease  in  our  tenapanor-related  expenses,  partially  offset  by  $3.0  million  of  higher  expenses  attributable  to  KKC
Research Agreement-related research and general R&D expenses. Of the overall tenapanor-related decrease, approximately
$11.0  million  relates  to  lower  clinical  study  costs  due  to  the  winding  down  of  expenses  associated  with  our  Phase  3
program for tenapanor for the control of hyperphosphatemia, offset by an out-of-period adjustment recorded during 2019
that  reduced  clinical  trial  expenses  by  $3.6  million  related  to  our  tenapanor  clinical  trials  for  the  nine  months  ended
September  30,  2019;  and  approximately  $2.9  million  relates  to  lower  manufacturing  expenses  due  to  reduced  validation
related  expenses  for  tenapanor  in  2020  as  compared  to  2019;  offset  by  an  increase  of  $3.1  million  related  to  regulatory
expenses  that  includes  $2.9  million  paid  to  the  FDA  for  the  filing  of  a  NDA  for  tenapanor  for  the  control  of  serum
phosphorus in CKD patients on dialysis in June  2020.

General and Administrative

The increase in general and administrative expenses for the year ended December 31, 2020 was primarily due to an
increase  in  costs  associated  with  building  and  staffing  our  commercial  infrastructure  and  teams  as  we  prepare  for  the
anticipated  U.S.  launch  of  tenapanor  for  the  control  of  serum  phosphorus  in  CKD  patients  on  dialysis.  The  increase
consisted of headcount and related personnel costs and an increase in external spending for disease awareness initiatives,
commercial infrastructure and strategy.

Other Income (Expense), net

Below is a summary of our other income (expense), net (dollars in thousands):

Interest expense
Other income, net

Total

Year Ended December 31, 

2020

  $  (5,099)
 1,568
$  (3,531)

2019
$  (5,726)
 2,352
$  (3,374)

$ Change
 627
 (784)
 (157)

$

$

% Change
 (11.0) %
 (33.3) %
 4.7 %

The decrease in interest expense for the year ended December 31, 2020 was primarily due to lower interest rates on

our variable-rate term loan.

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The  decrease  in  other  income,  net  for  the  year  ended  December  31,  2020    was  primarily  due  to  a  decrease  in
investment  income,  a  lower  exit  fee  revaluation  adjustment  related  to  our  loan  agreement  and  a  decrease  in  currency
exchange losses.

Comparison of the Years Ended December 31, 2019 and 2018

Revenue

Below is a summary of our operating expenses (dollars in thousands):

Collaborative development revenue
Product supply revenue
Licensing revenue
Total revenues

Year Ended December 31, 

  $

$

2019

2018

$ Change % Change

 459
 322
 4,500
 5,281

$

$

 — $  459
 35
 287
 2,180
 2,320
$  2,674
 2,607

n/m
 12.2 %
 94.0 %
 102.6 %

Total revenues for the year ended December 31, 2019 were $5.3 million, which represents an increase of $2.7 million,
or 102.6%, as compared to total revenues of $2.6 million for the year ended December 31, 2018. The licensing revenue of
$4.5 million is attributable to the achievement of a milestone, which amounted to $3.0 million, pursuant to our exclusive
license  agreement  with  Fosun  Pharma,  entered  into  in  December  2017  for  the  development,  commercialization  and
distribution  of  tenapanor  in  China  for  both  hyperphosphatemia  and  IBS-C,  and  the  full  recognition  of  the  $1.5  million
license fee related to the XuanZhu Agreement, as discussed in Note 12, Collaboration and Licensing Agreements, to our
financial statements, included in Part II, Item 8 of this Annual Report on Form 10-K.

The  increase  in  collaborative  development  revenue  is  attributed  to  revenue  recognized  during  the  fourth  quarter  of
2019  related  to  the  2019  KKC  Agreement.  We  expect  to  recognize  the  remaining  $9.5  million  of  the  initial  transaction
price  over  the  research  and  development  period  of  the  program,  which  we  currently  expect  to  extend  through  the  end
of  2021.  We  will  revisit  our  current  estimates  and  timing  of  performance  at  the  end  of  each  future  reporting  period  and
adjust as necessary.

Product supply revenue of $0.3 million relates to the manufacturing supply of tenapanor and other materials sold to

KKC in connection with that collaboration partner’s product development and clinical trials in Japan.

Operating Expenses

Below is a summary of our operating expenses (dollars in thousands):

Cost of revenue
Research and development
General administrative

Total

Year Ended December 31, 

2019

  $

 600
 71,677
 24,267
$  96,544

2018

$

 466
 69,373
 23,715
$  93,554

$ Change
 134
 2,304
 552
 2,990

$

$

% Change

 28.8 %
 3.3 %
 2.3 %
 3.2 %

Cost of Revenue

Cost  of  revenue  was  $0.6  million  for  the  year  ended  December  31,  2019,  an  increase  of  $0.1  million,  or  28.8%,
compared  to  $0.5  million  for  the  year  ended  December  31,  2018.  Cost  of  revenue  in  both  periods  is  the  portion  of
tenapanor-related  up  front  and  milestone  payment  from  our  collaboration  partners  that  we  are  required  to  make  to
AstraZeneca under the AstraZeneca Termination Agreement.

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Research and Development

Below is a summary of our research and development expenses (dollars in thousands):

External R&D expenses
Employee-related expenses
Facilities, equipment and
depreciation expenses
Other expenses

Total

Year Ended December 31, 

2019
 45,989
 19,466

 5,934
 288
 71,677

2018
 47,060
 16,666

 5,360
 287
 69,373

$

$

$

  $

$

$

$ Change

 (1,071)
 2,800

% Change
 (2.3) %
 16.8 %

 574
 1
 2,304

 10.7 %
 0.3 %
 3.3 %

Research and development expenses were $71.7 million for the year ended December 31, 2019, an increase of $2.3
million,  or  3.3%,  compared  to  $69.4  million  for  the  year  ended  December  31,  2018.  The  increase  consisted  of  a  $3.7
million increase to advance our internal pipeline programs and a $1.4 million decrease in our collaboration program costs.

The increase in our internal costs of $3.7 million was primarily due to an increase in headcount and related personnel

costs and an increase in stock-based compensation expenses.

The  decrease  in  our  external  program  costs  of  $1.4  million  included  a  $4.6  million  decrease  in  expenses  primarily
related to manufacturing of tenapanor and regulatory expenses related to our IBS-C NDA in 2018, partially offset by $2.5
million increase in clinical development expenses related to our RDX013 program and a $0.7 million increase primarily
related to our tenapanor clinical trial expenses that includes an out-of-period adjustment recorded during the second quarter
of 2019 that reduced clinical trial expenses by $3.6 million related to our tenapanor clinical trials.

General and Administrative

General and administrative expenses were $24.3 million for the year ended December 31, 2019, an increase of $0.6
million, or 2.3%, compared to $23.7 million for the year ended December 31, 2018. The increase was primarily due to an
increase in personnel costs, stock-based compensation expense, audit expenses and recruiting expenses, partially offset by
a decrease in other professional services.

Other Income (Expense), net

Below is a summary of our other income (expense), net (dollars in thousands):

Interest expense
Other income, net

Total

Year Ended December 31, 

2019

  $  (5,726)
 2,352
$  (3,374)

2018
$  (3,534)
 3,187
 (347)

$

$ Change
$  (2,192)
 (835)
$  (3,027)

% Change

 62.0 %
 (26.2) %
 872.3 %

Interest expense, net was $5.7 million for the year ended December 31, 2019, an increase of $2.2 million, or 62.0%,
compared  to  $3.5  million  for  the  year  ended  December  31,  2018.  The  increase  in  interest  expense  in  2019  compared  to
2018 was because the interest expense during 2018 represents only part of the year related to the loan agreement entered in
May 2018, as compared with a full year of interest expense in 2019.

Other  income,  net,  was  $2.4  million  for  the  year  ended  December  31,  2019,  which  represents  a  decrease  of  $0.8
million, or 26.2%, compared to $3.2 million for the year ended December 31, 2018. The decrease was primarily due to a
decrease in treasury-related income and revaluation adjustments related to our loan agreement.

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LIQUIDITY AND CAPITAL RESOURCES

Below is a summary of our cash, cash equivalents and marketable securities (in thousands):

December 31,  December 31,  

Cash and cash equivalents
Marketable securities - current
Marketable securities - non-current
Total liquid funds

  $

2019

2020
 91,032   $  181,133
 66,379
 95,452  
 —
 2,114  
$  247,512

$  188,598

As of December 31, 2020, we had cash, cash equivalents and marketable securities totaling $188.6 million compared

to $247.5 million as of December 31, 2019.

In July 2020, we filed a Form S-3 registration statement, which became effective in August 2020, containing (i) a base
prospectus  for  the  offering,  issuance  and  sale  by  the  Company  of  up  to  a  maximum  aggregate  offering  price  of  $250.0
million of the Company’s common stock, preferred stock, debt securities, warrants and/or units, from time to time in one or
more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by the Company of up to a maximum
aggregate offering price of $100.0 million of our common stock that may be issued and sold, from time to time, under a
sales agreement with Jefferies LLC, deemed to be “at the market offerings.” As of December 31, 2020, we have received
net proceeds of $21.2 million through the sale of approximately 3.3 million shares pursuant to this sales agreement.

On  December  9,  2019,  we  completed  an  underwritten  public  offering  of  20.0  million  shares  of  common  stock  at  a
price  of  $6.25  per  share before  underwriting  discounts  and  commissions  (“the  2019  Offering”).  In  connection  with  the
2019  Offering,  we  entered  into  an  underwriting  agreement  (“the  2019  Underwriting  Agreement”)  with  Citigroup  Global
Markets  Inc.,  Cowen  and  Company  LLC,  SVB  Leerink  LLC  and  Piper  Jaffray  &  Co.,  collectively  “the  2019
Underwriters”) pursuant to which we granted to the 2019 Underwriters a 30-day option to purchase up to an additional 3.0
million shares of our common stock (“the 2019 Overallotment”). We completed the sale of 23.0 million shares, inclusive of
the 2019 Overallotment, and that sale resulted in our receipt of aggregate gross proceeds of approximately $143.8 million,
less underwriting discounts, commissions and offering expenses totaling approximately $8.9 million, which resulted in net
proceeds of approximately $134.9 million.

On  November  22,  2019,  we  and  KKC  entered  into  a  stock  purchase  agreement,  pursuant  to  which  we  sold  an
aggregate  of  2.9  million  shares  of  our  common  stock  at  $6.96  per  share  for  aggregate  net  proceeds  of  approximately
$20.0 million, or the Private Placement. The Private Placement closed on November 25, 2019.

On May 25, 2018, we completed an underwritten public offering of 12.5 million shares of common stock at a price of
$4.00  per  share  before  underwriting  discounts  and  commissions  (“the  2018  Offering”).  In  connection  with  the  2018
Offering, we entered into an underwriting agreement (“the 2018 Underwriting Agreement”) with Jefferies LLC and SVB
Leerink (formerly known as Leerink Partners LLC), or together the 2018 Underwriters, pursuant to which we granted to
the 2018 Underwriters a 30-day option to purchase up to an additional 1.9 million shares of our common stock (“the 2018
Overallotment”). We completed the sale of 14.4 million, inclusive of the 2018 Overallotment, to the 2018 Underwriters.
That sale resulted in our receipt of aggregate gross proceeds of approximately $57.5 million, less underwriting discounts,
commissions and offering expenses totaling approximately $3.7 million, which resulted in net proceeds of approximately
$53.8 million.

On May 16, 2018, we entered into a loan and security agreement (“the Loan Agreement”) with Solar Capital Ltd. and
Western  Alliance  Bank  (“the  Lenders”).  The  Loan  Agreement  provides  for  a  $50.0  million  term  loan  facility  with  a
maturity date of November 1, 2022. The full amount of the loan was funded on May 16, 2018. We received net proceeds
from the loan of $49.3 million, after deducting the closing fee, legal expenses and issuance cost. On October 9, 2020, we
and the Lenders entered into an amendment to the Loan Agreement, as defined and discussed in Note 6, Borrowings, to
extend the date through which we are permitted to make interest-only payments on the Term Loan from December 1, 2020
to  December  1,  2021.  See  Note  6,  Borrowings,  in  the  notes  to  our  financial  statements,  included  in  Part  II,  Item  8,  for
details on our Loan Agreement.

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Our  primary  sources  of  cash  have  been  from  the  sale  and  issuance  of  common  stock  (in  both  public  offerings  and
private placements) and private placements of convertible preferred stock, funds from our collaboration partnerships and
funds  from  our  loan  agreement.  Our  primary  uses  of  cash  are  to  fund  operating  expenses,  primarily  research  and
development expenditures and pre-commercial expenses. Cash used to fund operating expenses is impacted by the timing
of when we pay these expenses, as reflected in the change in our outstanding accounts payable and accrued expenses.

We believe that our existing capital resources as of December 31, 2020 will enable us to fund our operating expenses
and capital expenditure requirements for at least the next 12 months following our financial statement issuance date. We
have based this estimate on assumptions that may prove to be wrong, and we could utilize our available capital resources
sooner than we currently expect. In particular, our operating plan can change, and we may require significant additional
capital  to  fund  our  operations,  including  to  support  the  development,  commercialization  and  manufacturing  efforts  for
tenapanor.  We  may  seek  to  obtain  such  additional  capital  through  debt  financings,  credit  facilities,  additional  equity
offerings and/or strategic collaborations. We currently have no unutilized credit facility or committed sources of capital,
and there can be no assurances that such sources of capital will be available to us when needed or on acceptable terms.
There are numerous risks and uncertainties associated with research, development and commercialization initiatives, and
actual results could vary materially as a result of a number of factors, many of which are outside of our control. Our future
capital requirements are difficult to forecast and will depend on many factors, including:

● the  FDA’s  actions  and  decisions  with  respect  to  the  NDA  submitted  to  the  FDA  on  June  30,  2020  to  request
marketing authorization for tenapanor for the control of serum phosphorus in adult CKD patients on dialysis;

● our  ability  to  successfully  commercialize  tenapanor  in  the  U.S.  for  the  control  of  serum  phosphorus  in  CKD

patients on dialysis, if approved;

● the sales price and the availability of adequate third-party reimbursement for tenapanor, if approved;

● the manufacturing costs of our product candidates, and the availability of one or more suppliers for our product

candidates at reasonable costs, both for clinical and commercial supply;

● the selling and marketing costs associated with tenapanor, including the cost and timing of building our sales and

marketing capabilities;

● our  ability  to  maintain  our  existing  collaboration  partnerships  and  to  establish  additional  collaboration
partnerships, in-license/out-license, joint ventures or other similar arrangements and the financial terms of such
agreements;

● the timing, receipt, and amount of sales of, or royalties on, tenapanor, if any;

● the cash requirements of any future acquisitions or discovery of product candidates;

● the number and scope of preclinical and discovery programs that we decide to pursue or initiate, and any clinical

trials we decide to pursue for other product candidates, including RDX013;

● the time and cost necessary to respond to technological and market developments;

● the  costs  of  filing,  prosecuting,  maintaining,  defending  and  enforcing  any  patent  claims  and  other  intellectual
property  rights,  including  litigation  costs  and  the  outcome  of  such  litigation,  including  costs  of  defending  any
claims of infringement brought by others in connection with the development, manufacture or commercialization
of tenapanor or any of our product candidates; and

● the payment of interest and principal related to our loan and security agreement entered into with Solar Capital

and Western Alliance Bank in May 2018, as amended on October 9, 2020.

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CASH FLOW ACTIVITIES

The following table summarizes our cash flows for the periods indicated (in thousands):

Cash used in operating activities
Cash (used in) provided by investing activities
Cash provided by financing activities
Net (decrease) increase in cash and cash equivalents

Cash Flows from Operating Activities

2020 compared to 2019

2018

2020

Year Ended December 31, 
2019
$ (81,435) $  (76,484) $  (70,274)
   (29,894)
 23,373
   (31,442)
   103,553
   155,476
 22,776
 3,385
$
$ (90,101) $ 102,365

Net  cash  used  in  operating  activities  during  the  year  ended  December  31,  2020  was  $81.4  million,  as  compared  to
$76.5  million  for  the  year  ended  December  31,  2019.  The  most  significant  factors  that  contributed  to  the  $5.0  million
increase in net cash used in operating activities for the year ended December 31, 2020, as compared to 2019 was primarily
a  $6.2  million  decrease  to  changes  in  operating  assets  and  liabilities,  primarily  driven  by  cash  received  in  2019  and
reported as deferred revenue for the KKC Research Agreement that was recognized as revenue in 2020, offset by a $0.6
million increase in non-cash charges and $0.6 million decrease to the net loss.

2019 compared to 2018

Net  cash  used  in  operating  activities  during  the  year  ended  December  31,  2019,  was  $76.5  million,  as  compared  to
$70.3 million of net cash used in operating activities during the year ended December 31, 2018. The $6.2 million increase
in  net  cash  used  in  operating  activities  is  predominantly  attributable  toa  $1.9  million  decrease  in  payments  made  to
AstraZeneca during 2019 in connection with the AZ Termination Agreement, as compared to payments made in 2018; a
$0.4 million increase in cash R&D expenses (excluding working capital-related fluctuations) in 2019, as compared to 2018;

● a $0.4 million decrease in cash G&A expenses (excluding working capital-related fluctuations) in 2019, as

compared to 2018;

● a $2.1 million increase in net cash interest payments in 2019, as compared to 2018;

● a $0.9 million decrease in cash paid for income taxes in 2019, as compared to 2018; and

● a  $6.5  million  net  increase  in  cash  used  related  to  fluctuations  in  components  of  our  non-revenue-related
working  capital  in  2019,  as  compared  to  2018,  which  was  comprised  of  a  $7.8  million  decrease,  a  $1.9
million  decrease  and  a  $0.4  million  decrease  in  cash  provided  by  fluctuations  in  our  non-payroll-related
accruals  and  other  current  liabilities,  lease  liability  and  prepaid  expenses  and  other  current  assets,
respectively,  partially  offset  by  a  $2.2  million  increase  and  a  $1.4  million  increase  of  cash  provided  by
fluctuations in our accrued compensation and benefits and accounts payable, respectively.

Cash Flows from Investing Activities

2020 compared to 2019

Net  cash  provided  by  investing  activities  decreased  by  $54.8  million  during  the  year  ended  December  31,  2020,  as
compared to the year ended December 31, 2019. This decrease was attributable to a $48.2 million increase in purchases of
available-for-sale  investments  and  a  decrease  in  proceeds  from  maturities  and  redemptions  of  short-term  investments  of
$6.6 million.

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2019 compared to 2018

Net  cash  provided  by  investing  activities  increased  by  $53.3  million  during  the  year  ended  December  31,  2019,  as
compared to the year ended December 31, 2018. This increase was attributable to a $66.3 million decrease in purchases of
short-term  available-for-sale  investments  and  a  $1.2  million  increase  in  sales  and  redemptions  of  investments,  partially
offset by a decrease in proceeds from maturities and redemptions of short-term investments of $13.1 million.

Cash Flows from Financing Activities

2020 compared to 2019

Net cash provided by financing activities decreased by $132.7 million during the year ended December 31, 2020, as
compared  to  the  year  ended  December  31,  2019.  This  decrease  was  predominantly  attributable  to  $134.9  million  in  net
proceeds received in connection with underwritten public offering initiatives that was received in 2019 but did not recur in
2020. This decrease was partially offset by $2.4 million net additional proceeds received in 2020 as compared to 2019 from
sales  of  our  common  stock  pursuant  to  our  at-the-market  sales  agreement  with  Jefferies  LLC,  employee  stock  plan
purchases and option exercises, and the 2019 sale of common stock in the Private Placement with KKC..

2019 compared to 2018

Net  cash  provided  by  financing  activities  increased  by  $51.9  million  during  the  year  ended  December  31,  2019,  as
compared to the year ended December 31, 2018. This increase was predominantly attributable to an $81.2 million increase
in  net  proceeds  received  in  connection  with  underwritten  public  offering  initiatives  and  a  $20.0  million  increase  in  net
proceeds  received  in  connection  with  the  Private  Placement,  partially  offset  by  a  net  $49.3  million  decrease  in  proceeds
received in connection with a long-term loan borrowing.

OFF-BALANCE SHEET ARRANGEMENTS

As of December 31, 2020 and 2019, respectively, we did not have any off-balance sheet arrangements as defined in

Item 303(a)(4) of Regulation S-K as promulgated by the SEC.

SMALLER REPORTING COMPANY AND NON-ACCELERATED FILER STATUS

On June 28, 2018, the SEC adopted amendments that raise the thresholds in the smaller reporting company, or SRC,
definition, whereby we were determined to qualify as an SRC. We elected to reflect that determination and avail ourselves
with most of the SRC scaled disclosure accommodations in our filings subsequent to the adoption. On March 12, 2020, the
SEC amended its rules to allow SRCs that have less than $100.0 million in annual revenue and a public float of less than
$700.0 million to qualify as a non-accelerated filer. As a non-accelerated filer, we are not required to obtain an opinion of
our independent auditors with respect to our internal controls over financial reporting for the period ended December 31,
2020.

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Interest Rate Risk

We are subject to market risks, including interest rate fluctuation exposure through our investments, in the ordinary
course of our business. However, the goals of our investment policy are the preservation of capital, fulfillment of liquidity
needs and fiduciary control of cash. To achieve our goal of maximizing income without assuming significant market risk,
we maintain our excess cash and cash equivalents in money market funds and short-term debt securities. Because of the
short-term maturities of our cash equivalents, we do not believe that a decrease in interest rates would have any material
negative impact on the fair value of our cash equivalents.

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As of December 31, 2020, we had cash, cash equivalents and marketable securities of $188.6 million, which consist of
bank  deposits  and  money  market  funds,  as  well  as  high  quality  fixed  income  instruments  including  corporate  bonds,
commercial paper, and asset-backed securities collateralized by non-mortgage consumer receivables. The credit rating of
our short-term investments must be rated A-1/P-1, or better by Standard and Poor’s and Moody’s Investors Service. Asset-
backed  securities  must  be  rated  AAA/Aaa.  Money  Market  funds  must  be  rated  AAAm/Aaa.  Such  interest-earning
instruments  carry  a  degree  of  interest  rate  risk.  However,  because  our  investments  are  high  quality  and  short-term  in
duration, we believe that our exposure to interest rate risk is not significant and that a 10% movement in market interest
rates  would  not  have  a  significant  impact  on  the  total  value  of  our  portfolio,  as  noted  above.  We  do  not  enter  into
investments for trading or speculative purposes.

We  are  subject  to  interest  rate  fluctuation  exposure  through  our  borrowings  under  the  Loan  Agreement  and  our
investment  in  money  market  accounts  which  bear  a  variable  interest  rate.  Borrowings  under  the  Loan  Agreement  bear
interest at a rate equal to one-month London Interbank Offered Rate, or LIBOR, plus 7.45% per annum. A hypothetical
increase  in  one-month  LIBOR  of  100  basis  points  above  the  current  one-month  LIBOR  rates  would  have  increased  our
interest expense by approximately $0.5 million for the year ended December 31, 2020. As of December 31, 2020, we had
an aggregate principal amount of $50.0 million outstanding pursuant to our Loan Agreement.

Foreign Currency Exchange Risk

The majority of our transactions are denominated in U.S. dollars. However, we do have certain transactions that are
denominated in currencies other than the U.S. dollar, primarily Swiss francs and the euro, and we therefore are subject to
foreign exchange risk. The fluctuation in the value of the U.S. dollar against other currencies affects the reported amounts
of expenses, assets and liabilities associated with a limited number of manufacturing activities.

We  do  not  use  derivative  financial  instruments  for  speculative  trading  purposes,  nor  do  we  hedge  foreign  currency
exchange rate exposure in a manner that entirely offsets the earnings effects of changes in foreign currency exchange rates.
The  counterparties  to  our  forward  foreign  currency  exchange  contracts  are  creditworthy  commercial  banks,  which
minimizes the risk of counterparty nonperformance.

As of December 31, 2020, we had no open forward foreign currency exchange contracts.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

ARDELYX, INC. 
INDEX TO FINANCIAL STATEMENTS

Report of Independent Registered Public Accounting Firm
Balance Sheets
Statements of Operations and Comprehensive Loss
Statements of Stockholders’ Equity
Statements of Cash Flows
Notes to Financial Statements

     79
81
82
83
84
85

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Report of Independent Registered Public Accounting Firm

To the Stockholders and the Board of Directors of Ardelyx, Inc.

Opinion on the Financial Statements

We have audited the accompanying balance sheets of Ardelyx, Inc. (the “Company”) as of December 31, 2020 and 2019,
the  related  statements  of  operations  and  comprehensive  loss,  stockholders’  equity,  and  cash  flows  for  each  of  the  three
years in the period ended December 31, 2020, and the related notes (collectively referred to as the “financial statements”).
In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of
December 31, 2020 and 2019, and the results of its operations and its cash flows for each of the three years in the period
ended December 31, 2020, in conformity with U.S. generally accepted accounting principles.

Basis for Opinion

These financial statements are the responsibility of the Company‘s management. Our responsibility is to express an opinion
on the Company‘s financial statements based on our audits. We are a public accounting firm registered with the PCAOB
and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We  conducted  our  audits  in  accordance  with  the  standards  of  the  PCAOB.  Those  standards  require  that  we  plan  and
perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement,
whether  due  to  error  or  fraud.  The  Company  is  not  required  to  have,  nor  were  we  engaged  to  perform,  an  audit  of  its
internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control
over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal
control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether
due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test
basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the
accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of
the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Critical Audit Matter

The critical audit matter communicated below is a matter arising from the current period audit of the financial statements
that  was  communicated  or  required  to  be  communicated  to  the  audit  committee  and  that:  (1)  relates  to  accounts  or
disclosures that are material to the financial statements and (2) involved our especially challenging, subjective or complex
judgments.  The  communication  of  the  critical  audit  matter  does  not  alter  in  any  way  our  opinion  on  the  financial
statements,  taken  as  a  whole,  and  we  are  not,  by  communicating  the  critical  audit  matter  below,  providing  a  separate
opinion on the critical audit matter or on the accounts or disclosures to which it relates.

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Description of the Matter

How We Addressed the Matter in
Our Audit

Accrued clinical and contract manufacturing expenses

During 2020, the Company incurred $65.1 million of research and development expenses
and accrued $2.2 million of clinical expenses and $1.8 million of contract manufacturing
expenses as of December 31, 2020. As described in Note 2 to the Financial Statements,
the  Company  estimates  the  accruals  for  its  contracts  with  third  party  service  providers
including contract research organizations (“CROs”), investigative sites, vendors related to
contract manufacturing, development and distribution of clinical supplies, and vendors in
connection  with  preclinical  development  activities,  which  comprise  a  significant
component  of  the  Company’s  research  and  development  activities.  External  costs  are
accrued  and  expensed  based  on  estimates  of  the  services  received  and  efforts  expended
pursuant  to  contracts  with  multiple  CROs,  investigative  sites,  contract  manufacturing
vendors,  and  preclinical  development  vendors.  The  timing  and  the  amount  of  payments
required under each individual arrangement are often different from the pattern of costs
actually incurred. The Company accrues the cost of the services under its contracts with
third party service providers based on the extent of activities completed by vendors over
the estimated service period, number of subjects enrolled, and number of sites activated.

third-party  service  providers, 

Auditing  management’s  accounting  for  accrued  clinical  and  contract  manufacturing
expenses is especially challenging because the evaluation is dependent on a high volume
of  data  exchanged  between 
internal  clinical  and
manufacturing personnel as well as the company’s finance team. Determining the accrued
amounts  is  based  on  an  evaluation  of  the  unique  terms  and  conditions  set  in  each
respective CRO, investigative site, contract manufacturing, and pre-clinical development
agreement. Additionally, due to the duration of clinical-related development activities and
the  timing  of  invoices  received  from  third  parties,  the  determination  of  the  accrual  for
services incurred requires application of judgment by management.

To  test  accrued  clinical  and  contract  manufacturing  expenses,  our  audit  procedures
included,  among  others,  testing  the  accuracy  and  completeness  of  the  inputs  used  in
management’s  analysis  to  determine  costs  incurred.  We  also  inspected  terms  and
conditions for material vendor contracts and change orders and compared these to the cost
models  management  used  in  tracking  progress  of  service  agreements.  We  met  with
internal legal personnel to understand material unique contract terms and conditions that
require  special  consideration  in  estimating  the  accrued  research  and  development
expenses.  We  met  with  internal  clinical  and  manufacturing  personnel  to  understand  the
status of significant clinical and contract manufacturing activities. We evaluated estimated
services incurred by third parties by understanding the terms and timeline of significant
projects,  evaluating  management’s  estimate  of  work  performed,  subjects  enrolled  and
sites  activated  and  costs  incurred,  and  obtaining  external  confirmation  of  contracts  and
change orders executed with the Company for a sample of vendors as well as key terms
and conditions of those contracts. Further, we inspected material invoices received from
third parties after the balance sheet date and evaluated whether services performed prior
to the balance sheet date had been properly included in the accrual.

/s/ Ernst & Young LLP

We have served as the Company’s auditor since 2009.

Redwood City, California
March 8, 2021

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ARDELYX, INC.
BALANCE SHEETS
(in thousands, except share and per share amounts)

Assets
Current assets:

Cash and cash equivalents
Short-term investments
Unbilled revenue
Prepaid expenses and other current assets

Total current assets
Property and equipment, net
Long-term investments
Right-of-use assets
Other assets

Total assets

Liabilities and stockholders’ equity
Current liabilities:
Accounts payable
Accrued compensation and benefits
Current portion of operating lease liability
Loan payable, current portion
Deferred revenue
Accrued expenses and other current liabilities

Total current liabilities

Operating lease liability, net of current portion
Loan payable, net of current portion

Total liabilities

Commitments and contingencies (Note 16)
Stockholders’ equity:

Preferred stock, $0.0001 par value; 5,000,000 shares authorized; no shares issued and
outstanding as of December 31, 2020 and December 31, 2019, respectively.
Common stock, $0.0001 par value; 300,000,000 shares authorized; 93,599,975 and
88,817,741 shares issued and outstanding as of December 31, 2020 and
December 31, 2019, respectively.
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive income

Total stockholders’ equity
Total liabilities and stockholders’ equity

December 31, 

2020

2019

$

91,032
95,452
—
8,202
194,686
1,936
2,114
2,274
552
$ 201,562

$ 181,133
66,379
750
3,800
252,062
3,436
—
3,970
314
$ 259,782

$

$

5,626
5,672
2,117
4,167
4,177
6,657
28,416
413
46,621
75,450

2,187
4,453
2,608
1,183
4,541
7,248
22,220
2,076
48,831
73,127

—  

—

9
680,872
(554,765)
(4)
126,112
$ 201,562

9
647,078
(460,452)
20
186,655
$ 259,782

The accompanying notes are an integral part of these financial statements.

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ARDELYX, INC.
STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(in thousands, except share and per share amounts)

Revenues:

Collaborative development revenue
Product supply revenue
Licensing revenue
Total revenues
Operating expenses:
Cost of revenue
Research and development
General and administrative
Total operating expenses

Loss from operations
Interest expense
Other income, net

Loss before provision for income taxes
Provision for income taxes
Net loss
Net loss per common share, basic and diluted
Shares used in computing net loss per share - basic and diluted
Comprehensive loss:
Net loss
Unrealized (losses) gains on available-for-sale securities
Comprehensive loss

2020

Year Ended December 31, 
2019

2018

$

$

5,364
1,501
706
7,571

$

459
322
4,500
5,281

—
287
2,320
2,607

145
65,053
33,153
98,351
(90,780)
(5,099)
1,568
(94,311)
2
(94,313) $
(1.05) $

$
$
  89,582,138

600
71,677
24,267
96,544
(91,263)
(5,726)
2,352
(94,637)
303
(94,940) $
(1.47) $

466
69,373
23,715
93,554
(90,947)
(3,534)
3,187
(91,294)
4
(91,298)
(1.62)
  56,219,919

  64,478,066

$

$

(94,313) $
(24)
(94,337) $

(94,940) $
58
(94,882) $

(91,298)
9
(91,289)

The accompanying notes are an integral part of these financial statements.

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ARDELYX, INC.
STATEMENTS OF STOCKHOLDERS’ EQUITY
(in thousands, except share amounts)

Additional
Paid-In
    Amount     Capital

Common Stock
Shares
47,534,979

$

Accumulated
Other

Accumulated Comprehensive

Deficit

     (Loss) Income     

Total
Stockholders'
Equity

5

$ 417,568

$ (278,214) $

(47) $ 139,312

4,000

—

4,000

Balance as of December 31, 2017
Adoption of ASU No. 2014-09 on
January 1, 2018
Issuance of common stock under
employee stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise
of options
Issuance of common stock upon vesting
of restricted stock units
Stock-based compensation
Unrealized gains on available-for-sale
securities
Issuance of common stock upon
underwritten public offering, net of
issuance costs
Net loss

Balance as of December 31, 2018
Issuance of common stock under
employee stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise
of options
Stock-based compensation
Unrealized gains on available-for-sale
securities
Issuance of common stock upon
underwritten public offering, net of
issuance costs
Issuance of common stock upon private
placement, net of issuance costs
Net loss

Balance as of December 31, 2019
Issuance of common stock under
employee stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise
of options
Issuance of common stock upon vesting
of restricted stock units
Stock-based compensation
Unrealized gains on available-for-sale
securities
Issuance of common stock in At-the-
market offering
Net loss

Balance as of December 31, 2020

—

—

120,959
75,183

  —  
  —  

—   —  

410,506

  —  
—   —  

—

491
303

—  

—  

9,226

—   —  

—  

—  
—  

—  

—  
—  

—  

14,375,000

1

53,769

—   —  

—  

  62,516,627

$

6

$ 481,357

—
(91,298)
$ (365,512) $

160,744
113,136

68,062
—

—

23,000,000

2,873,563
—
  88,817,741

$

169,931
42,403

445,942

866,528
—

—

3,257,430
—
  93,599,975

$

—
—

—
—

—

3

—
—
9

—
—

—

—
—

—

—
—
9

396
312

178
9,936

—

134,924

—
—

—
—

—

—

19,975
—
$ 647,078

—
(94,940)
$ (460,452) $

834
310

1,020

—
10,583

—

—
—

—

—
—

—

21,047
—
$ 680,872

—
(94,313)
$ (554,765) $

The accompanying notes are an integral part of these financial statements.

83

—  
—  

—  

—  
—  

9

491
303

—

—
9,226

9

53,770
—
—  
(91,298)
(38) $ 115,813

—
—

—
—

58

—

—
—
20

—
—

—

—
—

396
312

178
9,936

58

134,927

19,975
(94,940)
$ 186,655

834
310

1,020

—
10,583

(24)

(24)

21,047
—
—
(94,313)
(4) $ 126,112

    
    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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ARDELYX, INC. 
STATEMENTS OF CASH FLOWS
(in thousands)

Operating activities

Net loss
Adjustments to reconcile net loss to net cash used in operating activities:

Depreciation expense
Amortization of deferred financing costs
Amortization of deferred compensation for services
Amortization of premium on investment securities
Non-cash lease expense
Stock-based compensation
Change in derivative liabilities
Non-cash interest associated with debt discount accretion
Changes in operating assets and liabilities:

Unbilled revenue
Accounts receivable
Prepaid expenses and other assets
Accounts payable
Accrued compensation and benefits
Lease liabilities
Accrued and other liabilities
Deferred revenue

Net cash used in operating activities
Investing activities

Proceeds from maturities and redemptions of investments
Purchases of investments
Purchases of property and equipment

Net cash (used in) provided by investing activities
Financing activities

Proceeds from underwritten public offering, net of issuance costs
Proceeds from issuance of common stock upon private placement, net of
issuance costs
Proceeds from issuance of common stock in At-the-market offering, net of
issuance costs
Proceeds from issuance of common stock under equity incentive and stock
purchase plans
Proceeds from (payments for) loan payable, net of issuance costs

Net cash provided by financing activities
Net (decrease) increase in cash and cash equivalents
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Supplementary disclosure of cash flow information:

Cash paid for interest
Cash paid for income taxes

Supplementary disclosure of non-cash activities:

Right-of-use assets obtained in exchange for lease obligations
Issuance of common stock for services
Issuance of derivative in connection with issuance of loan payable

2020

2019

2018

$ (94,313) $ (94,940) $ (91,298)

1,824
496
313
(92)
2,147
10,583
407
413

750
—
(4,653)
3,439
1,219
(2,604)
(1,000)
(364)
(81,435)

2,501
670
309
(698)
1,839
9,936
436
478

4,250
85
93
39
1,730
(1,892)
(5,861)
4,541
(76,484)

2,678
236
253
(1,136)
—
9,226
111
303

—
10,711
525
(2,730)
(506)
—
1,353
—
(70,274)

  119,734
  (150,852)
(324)
(31,442)

  126,369
  (102,671)
(325)
23,373

139,450
  (169,033)
(311)
(29,894)

—   134,927

53,770

—

19,975

21,047

—

1,854
(125)
22,776
(90,101)
  181,133
91,032
$

574
—
  155,476
  102,365
78,768
$ 181,133

$
$

$
$
$

4,200
1

$
$

4,920
2

$
450
310
$
— $

$
5,810
312
$
— $

—

—

491
49,292
103,553
3,385
75,383
78,768

3,071
4

—
303
546

$

$
$

The accompanying notes are an integral part of these financial statements.

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ARDELYX, INC. 
NOTES TO FINANCIAL STATEMENTS

1.           ORGANIZATION AND BASIS OF PRESENTATION

Ardelyx,  Inc.  (the  “Company,”  “we,”  “us”  or  “our”)  is  a  specialized  biopharmaceutical  company  focused  on
developing  first-in-class  medicines  to  improve  treatment  choices  for  people  with  kidney  and  cardiorenal  diseases.  The
Company operates in one business segment, which is the research and development of biopharmaceutical products.

2.          SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation

The  accompanying  financial  statements  have  been  prepared  in  accordance  with  accounting  principles  generally

accepted in the United States of America (“U.S. GAAP”).

Prior Period Errors

In  connection  with  our  review  of  our  financial  statements  as  of  and  for  the  six  months  ended  June  30,  2019,  we
corrected errors related to the accounting for clinical trial accruals that had resulted in an overstatement of research and
development expenses during the year ended December 31, 2018. Specifically, management concluded that the Company’s
research  and  development  expenses  recorded  during  the  year  ended  December  31,  2018  had  been  overstated  by  $3.6
million and that the Company’s accrued expenses and other current liabilities as of December 31, 2018 had been overstated
by the same amount. Management analyzed the potential impact of these errors in accordance with the U.S. Securities and
Exchange Commission’s (“SEC”) Staff Accounting Bulletin No. 108, Considering the Effects of Prior Year Misstatements
when  Quantifying  Misstatements  in  Current  Year  Financial  Statements,  and  concluded  that  while  the  errors  were
significant  to  the  Company’s  financial  statements  as  of  and  for  the  six  months  ended  June  30,  2019,  a  correction  of  the
errors  would  not  have  been  material  to  the  full  year  results  for  2019  and  2018  nor  affect  the  trend  of  financial  results.
Accordingly, the Company reduced accrued and other liabilities by $3.6 million and recorded a cumulative adjustment of
$3.6 million in the statement of operations and comprehensive loss to reduce research and development expenses in 2019.

Use of Estimates

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and
judgments  that  affect  the  amounts  reported  in  the  financial  statements  and  accompanying  notes.  On  an  ongoing  basis,
management  evaluates  its  estimates,  including  those  related  to  recognition  of  revenue,  clinical  trial  accruals,  contract
manufacturing accruals, fair value of assets and liabilities, income taxes and stock-based compensation. Management bases
its  estimates  on  historical  experience  and  on  various  other  market-specific  and  relevant  assumptions  that  management
believes to be reasonable under the circumstances. Actual results could materially differ from those estimates.

Liquidity

As of December 31, 2020, the Company had cash and investments of approximately $188.6 million, which include net
proceeds of approximately $21.0 million from the 2020 At-the-Market Offerings, $134.9 million from the 2019 Offering,
and $20.0 million received in connection with the 2019 Private Placement, respectively, as defined and discussed in Note 7.
We  believe  our  current  available  cash  and  investments  will  be  sufficient  to  fund  our  planned  expenditures  and  meet  the
Company’s obligations for at least 12 months following March 8, 2021, which is the date that the financial statements are
being issued.

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Cash and Cash Equivalents

The Company considers all highly liquid investments purchased with an original maturity date of 90 days or less on

the date of purchase to be cash equivalents.

Short-Term Investments

Short-term  investments  consist  of  debt  securities  classified  as  available-for-sale  and  have  maturities  greater  than
90 days, but less than one year, from the date of acquisition. Short-term investments are carried at fair value based upon
quoted  market  prices.  Unrealized  gains  and  losses  on  available-for-sale  securities  are  excluded  from  earnings  and  are
reported as a component of accumulated other comprehensive loss. The cost of available-for-sale securities sold is based on
the specific-identification method.

Concentration of Credit Risk

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily
of cash, cash equivalents, short-term investments and accounts receivable. The Company is exposed to credit risks in the
event of default by the counterparties to the extent of the amount recorded in its balance sheet. Cash, cash equivalents and
short-term investments are invested through banks and other financial institutions in the U.S.

Foreign Currency and Forward Contracts

The Company manages its foreign currency exposures with the use of foreign currency purchases as well as currency
spot  and  forward  contracts.  The  Company  primarily  conducts  its  business  in  U.S.  dollars;  however,  a  portion  of  the
Company’s  expense  and  capital  activities  are  transacted  in  foreign  currencies  which  are  subject  to  exchange  rate
fluctuations that can affect cash or earnings. The Company has been in a loss position and therefore its primary objective is
to  conserve  and  manage  cash.  There  are  generally  two  methods  by  which  the  Company  manages  the  cash  flow  risk  of
foreign exchange fluctuations when a contract is signed (i) it can purchase the foreign funds, in full or in part, upon the
execution of the contract, or (ii) it can obtain the right to purchase such funds, in full or in part, at the execution of the
contract, i.e., obtain a forward contract from an appropriate bank, that can be exercised to obtain the currency of interest at
a particular point in time. The derivative instruments that the Company uses to hedge the exposure shall generally not be
designated as cash flow hedges, and as a result, changes in their fair value will be recorded in other income (expense), net,
in the Company's statements of operations and comprehensive loss. The fair values of forward foreign currency exchange
contracts are estimated using current exchange rates and interest rates and the current creditworthiness of the counterparties
is taken into consideration.

Property and Equipment

Property and equipment are stated at cost, less accumulated depreciation and amortization. Depreciation is computed
using the straight-line method over the estimated useful lives of the respective assets, with ranges generally from three to
five  years.  Leasehold  improvements  are  amortized  over  the  lesser  of  the  estimated  useful  lives  or  the  related  remaining
lease term.

Impairment of Long-Lived Assets

The  carrying  value  of  long-lived  assets,  including  property  and  equipment,  are  reviewed  for  impairment  whenever
events or changes in circumstances indicate that the asset may not be recoverable. An impairment loss is recognized when
the  total  of  estimated  future  undiscounted  cash  flows,  expected  to  result  from  the  use  of  the  asset  and  its  eventual
disposition, are less than the asset’s carrying amount. Impairment, if any, would be assessed using discounted cash flows or
other  appropriate  measures  of  fair  value.  For  the  years  ending  December  31,  2020,  2019  and  2018  there  have  been  no
impairment losses.

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Income Taxes

The  Company  uses  the  asset  and  liability  method  of  accounting  for  income  taxes.  Under  this  method,  deferred  tax
assets and liabilities are determined based on the differences between the financial reporting and the tax bases of assets and
liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to
reverse. A valuation allowance is provided when it is more likely than not that some portion or all of a deferred tax asset
will not be realized.

Revenue Recognition

On  January  1,  2018  the  Company  adopted  the  Financial  Accounting  Standards  Board’s  (“FASB”)  Accounting
Standards  Update  (“ASU”)  No.  2014-09,  Revenue  from  Contracts  with  Customers  (Topic  606)  and  related  amendments
(“ASC  606”),  on  a  modified  retrospective  basis,  which  resulted  in  an  adjustment  to  the  opening  accumulated  deficit
balance on the adoption date. As a result of the adoption of the new standard, on January 1, 2018, the Company recorded
the following: (i) unbilled revenue under current assets of $5.0 million representing a future receivable related to the first
milestone under the Company’s license agreement with Kyowa Kirin Co., Ltd. (formerly known as Kyowa Hakko Kirin
Co., Ltd, or KHK) (“KKC”), which was subsequently achieved by KKC and collected in February 2019, thereby reducing
the unbilled revenue balance to zero, (ii) uncharged license fees under current liabilities of $1.0 million representing the
corresponding future payable related to AstraZeneca AB, or AstraZeneca, in accordance with the Company’s termination
agreement  with  AstraZeneca,  which,  upon  KKC  achieving  the  milestone,  was  reclassified  to  accounts  payable  and
subsequently paid to AstraZeneca during the second quarter of 2019, and (iii) a related decrease in accumulated deficit of
approximately  $4.0  million  as  the  new  standard  permitted  revenue  from  milestones  that  possess  certain  criteria  to  be
recognized earlier and also contained different recognition criteria related to milestones than under the previous accounting
standard.

The  Company  generates  revenue  primarily  from  research  and  collaboration  and  license  agreements  with  customers.
Goods  and  services  in  the  agreements  may  include  the  grant  of  licenses  for  the  use  of  the  Company’s  technology,  the
provision  of  services  associated  with  the  research  and  development  of  product  candidates,  manufacturing  services,  and
participation in joint steering committees. The terms of these arrangements typically include payment to the Company of
one  or  more  of  the  following:  non-refundable,  up-front  license  fees;  research,  development,  regulatory  and  commercial
milestone  payments;  reimbursement  of  research  and  development  services;  option  payments;  reimbursement  of  certain
costs; payments for manufacturing supply services; and future royalties on net sales of licensed products.

When two or more contracts are entered into with the same customer at or near the same time, the Company evaluates
the contracts to determine whether the contracts should be accounted for as a single arrangement. Contracts are combined
and accounted for as a single arrangement if one or more of the following criteria are met: (i) the contracts are negotiated
as a package with a single commercial objective; (ii) the amount of consideration to be paid in one contract depends on the
price  or  performance  of  the  other  contract;  or  (iii)  the  goods  or  services  promised  in  the  contracts  (or  some  goods  or
services promised in each of the contracts) are a single performance obligation.

In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under each
of  its  agreements,  management  performs  the  following  steps:  (i)  identification  of  the  promised  goods  or  services  in  the
contract; (ii) determination of whether the promised goods or services are performance obligations including whether they
are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraints on variable
consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when
(or  as)  the  Company  satisfies  each  performance  obligation.  As  part  of  the  accounting  for  contracts  with  customers,  the
Company develops assumptions that require judgment to determine whether promised goods and services represent distinct
performance obligations and the standalone selling price for each performance obligation identified in the contract. This
evaluation is subjective and requires the Company to make judgments about the promised goods and services and whether
those goods and services are separable from other aspects of the contract. Further, determining the standalone selling price
for performance obligations requires significant judgment, and when an observable price of a promised good or service is
not readily available, the Company considers relevant assumptions to estimate the standalone selling price, including, as
applicable,  market  conditions,  development  timelines,  probabilities  of  technical  and  regulatory  success,  reimbursement
rates for personnel costs, forecasted revenues, potential limitations to the selling price of the product and discount rates.

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The Company applies judgment in determining whether a combined performance obligation is satisfied at a point in
time  or  over  time,  and,  if  over  time,  concluding  upon  the  appropriate  method  of  measuring  progress  to  be  applied  for
purposes of recognizing revenue. The Company evaluates the measure of progress each reporting period and, as estimates
related to the measure of progress change, related revenue recognition is adjusted accordingly. Changes in the Company’s
estimated  measure  of  progress  are  accounted  for  prospectively  as  a  change  in  accounting  estimate.  The  Company
recognizes  collaboration  revenue  by  measuring  the  progress  toward  complete  satisfaction  of  the  performance  obligation
using an input measure. In order to recognize revenue over the research and development period, the Company measures
actual costs incurred to date compared to the overall total expected costs to satisfy the performance obligation. Revenues
are recognized as the program costs are incurred. The Company will re-evaluate the estimate of expected costs to satisfy
the performance obligation each reporting period and make adjustments for any significant changes.

Amounts  received  prior  to  satisfying  the  revenue  recognition  criteria  are  recorded  as  contract  liabilities  in  the
Company’s balance sheets. If the related performance obligation is expected to be satisfied within the next twelve months
this will be classified in current liabilities. Amounts recognized as revenue prior to receipt are recorded as contract assets in
the Company's balance sheets. If the Company expects to have an unconditional right to receive the consideration in the
next twelve months, this will be classified in current assets. A net contract asset or liability is presented for each contract
with a customer.

Milestone  Payments:  At  the  inception  of  each  arrangement  that  includes  development  milestone  payments,  the
Company  evaluates  whether  the  milestones  are  considered  probable  of  being  reached  and  estimates  the  amount  to  be
included in the transaction price using the most likely amount method. Amounts of variable consideration are included in
the  transaction  price  to  the  extent  that  it  is  probable  that  a  significant  reversal  in  the  amount  of  cumulative  revenue
recognized  will  not  occur  and  when  the  uncertainty  associated  with  the  variable  consideration  is  subsequently  resolved.
Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are not
considered probable of being achieved until those approvals are received. The transaction price is then allocated to each
performance obligation on a relative standalone selling price basis, for which the Company recognizes revenue as or when
the performance obligations under the contract are satisfied. At the end of each subsequent reporting period, the Company
re-evaluates the probability of achievement of such development milestones and any related constraints, and if necessary,
adjusts  its  estimate  of  the  overall  transaction  price.  Any  such  adjustments  are  recorded  on  a  cumulative  catch-up  basis,
which would affect earnings in the period of adjustment.

Manufacturing  supply  services:  Arrangements  that  include  a  promise  for  future  supply  of  drug  substance  or  drug
product  for  either  clinical  development  or  commercial  supply  at  the  customer’s  discretion  are  generally  considered  as
options. The Company assess if these options provide a material right to the licensee and if so, they are accounted for as
separate  performance  obligations.  If  the  Company  is  entitled  to  additional  payments  when  the  customer  exercises  these
options, any payments are recorded in product supply revenue when the customer obtains control of the goods, which is
upon delivery.

Royalties:  For  arrangements  that  include  sales-based  royalties,  including  milestone  payments  based  on  the  level  of
sales, and where the license is deemed to be the predominant item to which the royalties relate, the Company recognizes
revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the
royalty has been allocated has been satisfied (or partially satisfied). To date, the Company has not recognized any royalty
revenue resulting from any of its licensing arrangements.

Licenses  of  intellectual  property:  If  a  license  granted  to  a  customer  to  use  the  Company’s  intellectual  property  is
determined to be distinct from the other performance obligations identified in the arrangement, the Company recognizes
revenue from consideration allocated to the license when the license is transferred to the licensee and the licensee is able to
use  and  benefit  from  the  license.  For  licenses  that  are  bundled  with  other  promises,  the  Company  applies  judgment  to
assess the nature of the combined performance obligation to determine whether the combined performance obligation is
satisfied over time or at a point in time and, if over time, to conclude upon the appropriate method of measuring progress
for purposes of recognizing revenue related to consideration allocated to the performance obligation.

Options:  Customer  options,  such  as  options  granted  to  allow  a  licensee  to  choose  to  research,  develop  and
commercialize licensed compounds are evaluated at contract inception in order to determine whether those options provide

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a material right (i.e., an optional good or service offered for free or at a discount) to the customer. If the customer options
represent a material right, the material right is treated as a separate performance obligation at the outset of the arrangement.
The  Company  allocates  the  transaction  price  to  material  rights  based  on  the  standalone  selling  price,  and  revenue  is
recognized when or as the future goods or services are transferred or when the option expires. Customer options that are
not  material  rights  do  not  give  rise  to  a  separate  performance  obligation,  and  as  such,  the  additional  consideration  that
would  result  from  a  customer  exercising  an  option  in  the  future  is  not  included  in  the  transaction  price  for  the  current
contract.  Instead,  the  option  is  deemed  a  marketing  offer,  and  additional  option  fee  payments  are  recognized  or  being
recognized as revenue when the licensee exercises the option. The exercise of an option that does not represent a material
right is treated as a separate contract for accounting purposes.

Contract modifications: Contract modifications, defined as changes in the scope or price (or both) of a contract that are
approved  by  the  parties  to  the  contract,  such  as  a  contract  amendment,  exist  when  the  parties  to  a  contract  approve  a
modification that either creates new or changes existing enforceable rights and obligations of the parties to the contract.
Depending  on  facts  and  circumstances,  the  Company  accounts  for  a  contract  modification  as  one  of  the  following:  (i)  a
separate contract; (ii) a termination of the existing contract and a creation of a new contract; or (iii) a combination of the
preceding treatments. A contract modification is accounted for as a separate contract if the scope of the contract increases
because of the addition of promised goods or services that are distinct and the price of the contract increases by an amount
of consideration that reflects the Company’s standalone selling prices of the additional promised goods or services. When a
contract modification is not considered a separate contract and the remaining goods or services are distinct from the goods
or  services  transferred  on  or  before  the  date  of  the  contract  modification,  the  Company  accounts  for  the  contract
modification as a termination of the existing contract and a creation of a new contract. When a contract modification is not
considered a separate contract and the remaining goods or services are not distinct, the Company accounts for the contract
modification as an add-on to the existing contract and as an adjustment to revenue on a cumulative catch-up basis.

The  Company  receives  payments  from  its  licensees  as  established  in  each  contract.  Upfront  payments  and  fees  are
recorded as deferred revenue upon receipt or when due and may require deferral of revenue recognition to a future period
until the Company performs its obligations under these arrangements. Where applicable, amounts are recorded as unbilled
revenue when the Company’s right to consideration is unconditional. The Company does not assess whether a contract with
a customer has a significant financing component if the expectation at contract inception is such that the period between
payment by the licensees and the transfer of the promised goods or services to the licensees will be one year or less.

Research and Development Costs

Research  and  development  costs  are  charged  to  expense  as  incurred  and  consist  of  costs  incurred  to  further  the
Company’s research and development activities and include salaries and related employee benefits, costs associated with
clinical  trials,  costs  related  to  pre-commercialization  manufacturing  activities  such  as  manufacturing  process  validation
activities  and  the  manufacturing  of  clinical  drug  supply,  nonclinical  research  and  development  activities,  regulatory
activities,  research-related  overhead  expenses  and  fees  paid  to  external  service  providers  and  contract  research  and
manufacturing organizations that conduct certain research and development activities on behalf of the Company.

Accrued Research and Development Expenses

The Company is required to estimate its accrued expenses at the end of each reporting period. This process involves
reviewing open contracts and purchase orders, communicating with Company personnel to identify services that have been
performed on the Company’s behalf and estimating the level of service performed and the associated cost incurred for the
service  when  the  Company  has  not  yet  been  invoiced  or  otherwise  notified  of  the  actual  costs.  The  majority  of  the
Company’s  service  providers  submit  invoices  in  arrears  for  services  performed  or  when  contractual  milestones  are  met.
The Company makes estimates of its accrued expenses as of each balance sheet date in the financial statements based on
facts  and  circumstances  known  to  the  Company  at  that  time.  The  Company  periodically  confirms  the  accuracy  of  its
estimates  with  the  service  providers  and  makes  adjustments  if  necessary.  Examples  of  estimated  accrued  research  and
development expenses include fees paid to:

● contract research organizations, or CROs, in connection with clinical studies;

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● investigative sites in connection with clinical studies;

● vendors related to product manufacturing, development and distribution of clinical supplies; and

● vendors in connection with preclinical development activities.

The  Company  records  expenses  related  to  clinical  studies  and  manufacturing  development  activities  based  on  its
estimates  of  the  services  received  and  efforts  expended  pursuant  to  contracts  with  multiple  CROs  and  manufacturing
vendors  that  conduct  and  manage  these  activities  on  the  Company’s  behalf.  The  financial  terms  of  these  agreements  are
subject to negotiation, vary from contract to contract, and may result in uneven payment flows. There may be instances in
which payments made to the Company’s vendors will exceed the level of services provided and result in a prepayment of
the expense. Payments under some of these contracts depend on factors such as the successful enrollment of subjects and
the  completion  of  clinical  trial  milestones.  In  accruing  service  fees,  the  Company  estimates  the  time  period  over  which
services will be performed, enrollment of subjects, number of sites activated and the level of effort to be expended in each
period. If the actual timing of the performance of services or the level of effort varies from the Company’s estimate, the
Company will adjust the accrued or prepaid expense balance accordingly.

Stock-Based Compensation

The  Company  recognizes  compensation  expense  for  all  stock-based  payment  awards  made  to  employees,
nonemployees and directors based on estimated fair values. For employee and nonemployee stock options, the Company
determines the grant date fair value of the awards using the Black-Scholes option-pricing model and generally recognizes
the  fair  value  as  stock-based  compensation  expense  on  a  straight-line  basis  over  the  vesting  period  of  the  respective
awards. For restricted stock and performance-based restricted stock, to the extent they are probable, the compensation cost
for  these  awards  is  based  on  the  closing  price  of  the  Company’s  common  stock  on  the  date  of  grant  and  recognized  as
compensation expense on a straight-line basis over the requisite service period. Stock-based compensation expense is based
on  the  value  of  the  portion  of  stock-based  payment  awards  that  is  ultimately  expected  to  vest.  As  such,  the  Company’s
stock-based  compensation  is  reduced  for  the  estimated  forfeitures  at  the  date  of  grant  and  revised,  if  necessary,  in
subsequent periods if actual forfeitures differ from those estimates.

Derivatives and Hedging Activities

The Company accounts for its derivative instruments as either assets or liabilities on the balance sheet and measures
them at fair value. Derivatives are adjusted to fair value through other income (expense), net in the statements of operations
and comprehensive loss.

Leases

The  Company  determines  if  an  arrangement  is  a  lease  at  the  inception  of  the  arrangement.  Operating  leases  are
included  in  right-of-use  assets,  current  portion  of  operating  lease  liability,  and  operating  lease  liability,  net  of  current
portion in our balance sheets. Right-of-use assets represent the Company’s right to use an underlying asset for the lease
term and lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease right-of-
use assets and liabilities are recognized at the lease commencement date based on the present value of lease payments over
the lease term. In determining the present value of lease payments, the Company uses its incremental borrowing rate based
on the information available at the lease commencement date. The operating lease right-of-use assets also include any lease
payments made and exclude lease incentives. The Company’s lease terms may include options to extend or terminate the
lease  when  it  is  reasonably  certain  that  the  Company  will  exercise  any  such  options.  Lease  expense  is  recognized  on  a
straight-line basis over the expected lease term. The Company has elected not to separate lease and non-lease components,
such as common area maintenance charges, and instead it accounts for these as a single lease component.

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Comprehensive Loss

Comprehensive  loss  is  composed  of  two  components:  net  loss  and  other  comprehensive  income  (loss).  Other
comprehensive  income  (loss)  refers  to  gains  and  losses  that  are  recorded  as  an  element  of  stockholders’  equity  but  are
excluded from net loss.

Net Loss per Share

Basic net loss per common share is calculated by dividing the net loss by the weighted-average number of common
shares outstanding during the period, without consideration of potential common shares. Diluted net loss per common share
in the periods presented is the same as basic net loss per common share, since the effects of potentially dilutive securities
are antidilutive due to the net loss for all periods presented.

Recent Accounting Pronouncements

New Accounting Pronouncements - Recently Adopted

In December 2019, as part of its initiative to reduce complexity in the accounting standards, the Financial Accounting
Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2019-12, Income Taxes (Topic 740): Simplifying
the Accounting for Income Taxes (“ASU 2019-12”), which eliminates certain exceptions related to the approach for intra-
period tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax
liabilities  for  outside  basis  differences.  ASU  2019-12  also  clarifies  and  simplifies  other  aspects  of  the  accounting  for
income  taxes.  The  standard  is  effective  for  fiscal  years,  and  interim  periods  within  those  fiscal  years,  beginning  after
December 15, 2020, with early adoption permitted. The Company early adopted ASU 2019-12 on April 1, 2020 and this
adoption had no material impact on the Company’s financial position or results of operations.

In  November  2018,  the  FASB  issued  ASU  2018-18,  Collaborative  Arrangements  (Topic  808):  Clarifying  the
Interaction  between  Topic  808  and  Topic  606  (“ASU  2018-18”),  which  clarifies  that  certain  transactions  between
collaborative  arrangement  participants  should  be  accounted  for  as  revenue  under  the  FASB’s  Accounting  Standards
Codification (“ASC”) No. 606, Revenue from Contracts with Customers (“ASC 606”) when the collaborative arrangement
participant is a customer. The Company adopted ASU 2018-18 on January 1, 2020, and the adoption of this standard did
not have a material impact on the Company’s financial statements.

In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—
Changes to the Disclosure Requirements for Fair Value Measurement (“ASU 2018-13”), which considers cost and benefits
and removes, modifies and adds disclosure requirements in Topic 820. The amendments on changes in unrealized gains and
losses, the range and weighted average of significant unobservable inputs used to develop Level 3 fair value measurements
and the narrative description of measurement uncertainty is to be applied prospectively for only the most recent interim or
annual period presented in the initial fiscal year of adoption. All other amendments were to be applied retrospectively to all
periods presented. The Company adopted ASU 2018-13 on January 1, 2020, and the adoption of this standard did not have
a material impact on the Company’s financial statements.

In  August  2018,  the  FASB  issued  ASU  No.  2018-15,  Intangibles  (Topic  350):  Customer’s  Accounting  for
Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract. The amendments in this
Update  align  the  requirements  for  capitalizing  implementation  costs  incurred  in  a  hosting  arrangement  that  is  a  service
contract  with  the  requirements  for  capitalizing  implementation  costs  incurred  to  develop  or  obtain  internal-use  software
(and  hosting  arrangements  that  include  an  internal-use  software  license).  This  ASU  requires  a  customer  in  a  cloud
computing arrangement (i.e. hosting arrangement) that is a service contract to follow the internal-use software guidance in
ASC 350-40 to determine which implementation costs to capitalize as assets or expense as incurred. ASC 350-40 requires
that  certain  costs  incurred  during  the  application  development  stage  be  capitalized  and  other  costs  incurred  during  the
preliminary project and post-implementation stages be expensed as incurred. We adopted this ASU on January 1, 2020 and
the adoption of this standard did not have a material impact on our financial statements.

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In March 2020, the FASB issued ASU No. 2020-04, Reference Rate Reform (Topic 848): Facilitation of the Effects of
Reference Rate Reform on Financial Reporting, which provides temporary optional guidance to companies impacted by the
transition  away  from  the  London  Interbank  Offered  Rate  (“LIBOR”).  The  guidance  provides  certain  expedients  and
exceptions to applying GAAP in order to lessen the potential accounting burden when contracts, hedging relationships, and
other transactions that reference LIBOR as a benchmark rate are modified. This guidance was effective upon issuance and
expires on December 31, 2022. The Company adopted ASU 2020-04 on April 1, 2020, and the adoption of this standard
did not have a material impact on the Company’s financial statements.

Recent Accounting Pronouncements Not Yet Adopted

In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments - Credit Losses (Topic 326): Measurement of
Credit Losses on Financial Instruments, an amendment which modifies the measurement and recognition of credit losses
for most financial assets and certain other instruments. The amendment updates the guidance for measuring and recording
credit losses on financial assets measured at amortized cost by replacing the “incurred loss” model with an “expected loss”
model. Accordingly, these financial assets will be presented at the net amount expected to be collected. The amendment
also requires that credit losses related to available-for-sale debt securities be recorded as an allowance through net income
rather than reducing the carrying amount under the current, other-than-temporary-impairment model. For smaller reporting
companies the guidance is effective for fiscal years beginning after December 15, 2022, including interim periods within
those  fiscal  years.  Early  adoption  is  permitted.  Management  is  currently  assessing  the  impact  of  this  standard  on  the
Company’s financial statements.

3.           CASH AND INVESTMENTS

Securities classified as cash and investments as of December 31, 2020 and December 31, 2019 are summarized below

(in thousands). Estimated fair value is based on quoted market prices for these investments.

     Amortized Cost     

Gains

Losses

Fair Value

December 31, 2020
Gross Unrealized

Cash and cash equivalents:
Money market funds
Commercial paper
Cash

Total cash and cash equivalents
Short-term investments:
    Commercial paper
    Corporate bonds
    U.S. government-sponsored agency bonds
    U.S. treasury notes
Total short-term investments
Long-term investments:
    Corporate bonds
Total cash equivalents and investments

$

$

$
$

$

$

$
$

88,151
2,100
781
91,032

60,631
24,547
9,277
1,000
95,455

2,115
188,602

92

— $
—  
—
—

$

2
3
2

—  

7

— $
$

7

— $
—  
—
—

$

(4)
(6)
—
—  
(10)

(1)
(11)

$
$

88,151
2,100
781
91,032

60,629
24,544
9,279
1,000
95,452

2,114
188,598

    
    
 
   
   
   
  
 
 
 
  
 
  
 
 
  
 
 
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Cash and cash equivalents:
Money market funds
Commercial paper
Corporate bonds
Cash

Total cash and cash equivalents
Short-term investments
    Commercial paper
    Corporate bonds
    Asset-backed securities
Total short-term investments
Total cash equivalents and short-term
investments

     Amortized Cost     

Gains

Losses

Fair Value

December 31, 2019
Gross Unrealized

$

$

$

$

147,208
19,357
11,441
3,124
181,130

36,667
21,690
8,005
66,362

$

247,492

$

— $

3

—  
—
3

$

14
6

—  
20

23

$

— $
—  
—  
—
—

— $
(3)
—  
(3)

147,208
19,360
11,441
3,124
181,133

36,681
21,693
8,005
66,379

(3)

$

247,512

Cash equivalents consist of money market funds and other debt securities with original maturities of three months or
less at the time of purchase, and the carrying amount is a reasonable approximation of fair value. The Company invests its
cash in high quality securities of financial and commercial institutions. These securities are carried at fair value, which is
based  on  readily  available  market  information,  with  unrealized  gains  and  losses  included  in  accumulated  other
comprehensive income (loss) within stockholders’ equity on the Company’s balance sheets. The Company uses the specific
identification method to determine the amount of realized gains or losses on sales of marketable securities. Realized gains
or losses have been insignificant and are included in other income (expense), net, in the statement of operations.

As of December 31, 2020, the Company held both short- and long-term investments. All short-term available-for-sale
securities  held  as  of  December  31,  2020  and  2019,  had  contractual  maturities  of  less  than  one  year.  The  long-term
securities held as of December 31, 2020 had contractual maturities greater than one year. The Company’s available-for-sale
securities are subject to a periodic impairment review. The Company considers a debt security to be impaired when its fair
value is less than its carrying cost, in which case the Company would further review the investment to determine whether it
is other-than-temporarily impaired. When the Company evaluates an investment for other-than-temporary impairment, the
Company reviews factors such as the length of time and extent to which fair value has been below cost basis, the financial
condition of the issuer and any changes thereto, intent to sell, and whether it is more likely than not the Company will be
required to sell the investment before the recovery of its cost basis. If an investment is other-than-temporarily impaired, the
Company writes it down through the statement of operations to its fair value and establishes that value as a new cost basis
for the investment. The Company did not identify any of its available-for-sale securities as other-than-temporarily impaired
in any of the periods presented. As of December 31, 2020 and 2019, no investment was in a continuous unrealized loss
position for more than one year and the Company believes that it is more likely than not that the investments will be held
until maturity or a forecasted recovery of fair value.

As  of  December  31,  2020,  the  amortized  cost  and  estimated  fair  value  of  available-for-sale  debt  securities  by

contractual maturity were as follows (in thousands):

Due in one year or less
Due in one to two years
Total

4.          FAIR VALUE MEASUREMENTS

Amortized Cost
95,455
2,115
97,570

$

$

$

$

Fair Value

95,452
2,114
97,566

Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit

price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market

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participants  on  the  measurement  date.  Valuation  techniques  used  to  measure  fair  value  must  maximize  the  use  of
observable inputs and minimize the use of unobservable inputs.
The three-level hierarchy for the inputs to valuation techniques is briefly summarized as follows:

Level 1   – Valuations are based on quoted prices in active markets for identical assets or liabilities and readily
accessible  by  the  Company  at  the  reporting  date.  Examples  of  assets  and  liabilities  utilizing  Level  1  inputs  are
certain money market funds, U.S. treasuries and trading securities with quoted prices on active markets.

Level 2   –  Valuations based on inputs other than Level 1 that are observable, either directly or indirectly, such as
quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are
observable  or  can  be  corroborated  by  observable  market  data  for  substantially  the  full  term  of  the  assets  or
liabilities.  Examples  of  assets  and  liabilities  utilizing  Level  2  inputs  are  corporate  bonds,  commercial  paper,
certificates of deposit and over-the-counter derivatives.

Level 3  –   Valuations based on unobservable inputs in which there is little or no market data, which require the
Company to develop its own assumptions.

The following table sets forth the fair value of the Company’s financial assets and liabilities measured on a recurring

basis by level within the fair value hierarchy (in thousands):

Assets:

Money market funds
Commercial paper
Corporate bonds
U.S. government-sponsored agency bonds
U.S. treasury notes

Total

Liabilities:

Derivative liability for Exit Fee

Total

Assets:

Money market funds
Commercial paper
Corporate bonds
Asset-backed securities

Total

Liabilities:

Derivative liability for Exit Fee

Total

Total
Fair Value

88,151
62,729
26,658
9,279
1,000
187,817

1,376
1,376

Total
Fair Value

147,208
56,041
33,134
8,005
244,388

969
969

$

$

$
$

$

$

$
$

$

$

$
$

$

$

$
$

December 31, 2020

Level 1

Level 2

Level 3

88,151

$
—  
—  
—
—  
$

88,151

— $

62,729
26,658
9,279
1,000
99,666

$

—
—
—

—
—

— $
— $

— $
— $

1,376
1,376

December 31, 2019

Level 1

Level 2

Level 3

147,208

$
—  
—  
—  
$

— $

56,041
33,134
8,005
97,180

$

—
—
—
—
—

147,208

— $
— $

— $
— $

969
969

Where  quoted  prices  are  available  in  an  active  market,  securities  are  classified  as  Level  1.  The  Company  classifies
money  market  funds,  U.S.  treasury  securities  and  U.S.  treasury  notes  as  Level  1.  When  quoted  market  prices  are  not
available  for  the  specific  security,  the  Company  estimates  fair  value  by  using  benchmark  yields,  reported  trades,
broker/dealer quotes and issuer spreads. The Company classifies corporate bonds, commercial paper, asset-backed

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securities  and  foreign  currency  derivative  contracts  as  Level  2.  In  certain  cases,  where  there  is  limited  activity  or  less
transparency around inputs to valuation, securities or derivative liabilities such as the Exit Fee, as defined and discussed in
Note 6, are classified as Level 3.

The carrying amounts reflected in the balance sheets for cash equivalents, short-term investments, accounts receivable,
prepaid  expenses  and  other  current  assets,  accounts  payable  and  accrued  expenses  approximate  their  fair  values  at  both
December 31, 2020 and December 31, 2019, due to their short-term nature.

Fair Value of Debt

The  interest  rate  of  the  Company’s  term  loan  facility  approximates  the  rate  at  which  the  Company  could  obtain
alternative financing. Therefore, the carrying amount of the term loan facility approximated its fair value at December 31,
2020 and 2019.

5.

DERIVATIVE LIABILITY

Exit Fee

In May 2018, in connection with entering into the Loan Agreement, as defined and discussed in Note 6, the Company
entered into an agreement pursuant to which the Company agreed to pay $1.5 million in cash, or the Exit Fee, upon any
change of control transaction in respect of the Company or if the Company obtains both (i) FDA approval of tenapanor for
the treatment of hyperphosphatemia in CKD patients on dialysis and (ii) FDA approval of tenapanor for the treatment of
patients with irritable bowel syndrome with constipation, or IBS-C, which was obtained on September 12, 2019 when the
FDA approved IBSRELA® (tenapanor), a 50 mg, twice daily oral pill for the treatment of IBS-C, in adults (the “Exit Fee
Agreement”). Notwithstanding the prepayment or termination of the Term Loan, the Company’s obligation to pay the Exit
Fee will expire on May 16, 2028. The Company concluded that the Exit Fee is a freestanding derivative which should be
accounted for at fair value on a recurring basis. The estimated fair value of the Exit Fee is recorded as a derivative liability
and included in accrued expense and other current liabilities on the accompanying balance sheets.

The fair value of the derivative liability was determined using a discounted cash flow analysis and is classified as a
Level  3  measurement  within  the  fair  value  hierarchy  since  the  Company’s  valuation  utilized  significant  unobservable
inputs. Specifically, the key assumptions included in the calculation of the estimated fair value of the derivative instrument
include: i) the Company’s estimates of both the probability and timing of a potential $1.5 million payment to Solar Capital
Ltd.  and  Western  Alliance  Bank  as  a  result  of  the  FDA  approvals,  and  ii)  a  discount  rate  which  was  derived  from  the
Company's  estimated  cost  of  debt,  adjusted  with  current  LIBOR.  Generally,  increases  or  decreases  in  the  probability  of
occurrence would result in a directionally similar impact in the fair value measurement of the derivative instrument and it
is estimated that a 10% increase (decrease),  not  to  exceed  100%,  in  the  probability  of  occurrence  would  result  in  a  fair
value fluctuation of no more than $0.1 million.

Changes in the fair value of recurring measurements included in Level 3 of the fair value hierarchy are presented as
other income (expense), net in the Company's statements of operations and were as follows for the years ended December
31, 2020, 2019 and 2018 (in thousands):

Fair value of Exit Fee derivative liability at January 1

Change in estimated fair value of derivative liability
Fair value of Exit Fee derivative liability at December 31

$

$

969
407
1,376

$

$

533
436
969 $

—
533
533

2020

2019

2018

6.  

BORROWINGS

Solar Capital and Western Alliance Bank Loan Agreement

On May 16, 2018, the Company entered into a loan and security agreement, or the Loan Agreement, with Solar Capital
Ltd. and Western Alliance Bank (“the Lenders”). The Loan Agreement provides for a $50.0 million term loan facility with

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a maturity date of November 1, 2022 (”the Term Loan”). The full amount of the Tern Loan was funded on May 16, 2018.
The Company received net proceeds from the loan of approximately $49.3 million, after deducting the closing fee, legal
expenses and issuance costs. On October 9, 2020, the Company and the Lenders entered into an amendment to the Loan
Agreement  (“the  2020  Amendment”)  to  extend  the  date  through  which  the  Company  is  permitted  to  make  interest-only
payments on the Term Loan by twelve months to December 1, 2021 subject to the repayment terms noted below.

Borrowings under the Term Loan bear interest at a floating per annum rate equal to 7.45% plus the one-month London
Inter-bank  Offered  Rate,  or  LIBOR.  The  Company  was  permitted  to  make  interest-only  payments  on  the  Term  Loan
through  June  1,  2020,  until  it  achieved  its  primary  endpoint  in  the  Phase  3  study  of  tenapanor  for  the  treatment  of
hyperphosphatemia in end-stage renal disease patients on dialysis, prior to June 1, 2020, in which case the Company would
have been permitted to make interest-only payments on the Term Loan through December 1, 2020. On December 3, 2019,
the  Company  reported  positive  topline  results  for  PHREEDOM,  a  long-term  Phase  3  study  evaluating  the  efficacy  and
safety of tenapanor as monotherapy for the treatment of hyperphosphatemia in patients with CKD on dialysis. The Lenders
were in agreement that these positive data from the Phase 3 PHREEDOM study achieve the “Phase 3 Endpoint” required
by  the  Term  Loan  to  extend  the  interest  only  period  by  six  months  to  December  1,  2020.  Subsequent  to  the  2020
Amendment,  the  interest  only  period  was  extended  an  additional  twelve  months  to  December  1,  2021.  Accordingly,
beginning on December 1, 2021 through the maturity date, the Company will be required to make monthly payments of
interest  plus  repayment  of  the  Term  Loan  in  consecutive  equal  monthly  installments  of  principal.  If  however,  either  the
FDA does not approve the Company’s New Drug Application for tenapanor for control of serum phosphorus in adult CKD
on dialysis on or before May 31, 2021 or the FDA issues a complete response letter (“CRL”) for tenapanor for the control
of serum phosphorus in adult CKD on dialysis, then the Company is to begin principal payments on the earlier of June 1,
2021  or  the  first  day  of  the  month  immediately  following  the  date  that  the  FDA  issues  a  CRL  to  the  Company.  The
Company paid a closing fee of $0.5 million, upon the closing of the Term Loan and $0.1 million upon closing of the 2020
Amendment. Under the Term Loan, the Company was obligated to pay a final fee equal to 3.95% of the Term Loan upon
the earliest to occur of the maturity date, the acceleration of the Term Loan, the prepayment or repayment of the Term Loan
or the termination of the Loan Agreement. Under the 2020 Amendment, the final fee was increased to 4.95% of the Term
Loan. The Company may voluntarily prepay the outstanding Term Loan, subject to a prepayment premium of (i) 3% of the
principal  amount  of  the  Term  Loan  if  prepaid  prior  to  or  on  the  first  anniversary  of  the  Closing  Date,  (ii)  2%  of  the
principal  amount  of  the  Term  Loan  if  prepaid  after  the  first  anniversary  of  the  Closing  Date  through  and  including  the
second anniversary of the Closing Date, or (iii) 1% of the principal amount of the Term Loan if prepaid after the second
anniversary  of  the  Closing  Date  and  prior  to  the  maturity  date.  The  Term  Loan  is  secured  by  substantially  all  the
Company’s assets, except for the Company’s intellectual property and certain other customary exclusions. Additionally, in
connection with the Term Loan, the Company entered into the Exit Fee Agreement, as discussed in Note 4.

The  Loan  Agreement  contains  customary  representations  and  warranties  and  customary  affirmative  and  negative
covenants, including restrictions on payment of dividends for our common stock. As of December 31, 2020, the Company
was in compliance with all of the covenants set forth in the Loan Agreement.

In addition, the Loan Agreement contains customary events of default that entitle the Lender to cause the Company’s
indebtedness  under  the  Loan  Agreement  to  become  immediately  due  and  payable,  and  to  exercise  remedies  against  the
Company  and  the  collateral  securing  the  Term  Loan,  including  its  cash.  Upon  the  occurrence  and  for  the  duration  of  an
event of default, an additional default interest rate equal to 4.0% per annum will apply to all obligations owed under the
Loan  Agreement.  As  of  December  31,  2020,  to  the  Company’s  knowledge,  there  were  no  facts  or  circumstances  in
existence that would give rise to an event of default.

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As of December 31, 2020, the Company’s future debt payment obligations towards the Term Loan principal and final

fee, excluding interest payments and the Exit Fee are as follows (in thousands):

2021
2022

Total repayment obligations

Less: Unamortized discount and debt issuance costs
Less: Unaccreted value of final fee

Loan payable

Less: Loan payable, current portion
Loan payable, net of current portion

7.

STOCKHOLDERS’ EQUITY

4,167
$
  48,308
$ 52,475
(518)
(1,169)
50,788
(4,167)
$ 46,621

In July 2020, the Company filed a Form S-3 registration statement, which became effective in August 2020, containing
(i) a base prospectus for the offering, issuance and sale by the Company of up to a maximum aggregate offering price of
$250.0 million of the Company’s common stock, preferred stock, debt securities, warrants and/or units, from time to time
in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by the Company of up to a
maximum aggregate offering price of $100.0 million of its common stock that may be issued and sold, from time to time,
under an Open Market Sales Agreement with Jefferies LLC, as sales agent, deemed to be “at the market offerings.” As of
December 31, 2020, we had sold 3.3 million shares of our common stock for aggregate gross proceeds of $21.7 million at a
weighted average price of $6.65 per share under the Open Market Sales Agreement. From the period of January 2, 2021
through February 28, 2021, we sold an additional 4.9 million shares of our common stock for aggregate gross proceeds of
$35.0  million  at  a  weighted  average  price  of  $7.09  per  share.  In  aggregate  during  the  life  of  the  Open  Market  Sales
Agreement,  we  have  sold  8.2  million  shares  of  our  common  stock  for  aggregate  gross  proceeds  of  $56.7  million  at  a
weighted average sales price of approximately $6.91 per share. Pursuant to the Open Market Sales Agreement, Jefferies, as
sales agent, receives a commission of up to 3.0% of the gross sales price for shares of common stock sold under the Open
Market Sales Agreement.

On  December  9,  2019,  the  Company  completed  an  underwritten  public  offering  of  20.0  million  shares  of  common
stock at a price of $6.25 per share before  underwriting  discounts  and  commissions,  or  the  2019  Offering.  In  connection
with the 2019 Offering, the Company entered into an underwriting agreement, or the 2019 Underwriting Agreement, with
Citigroup Global Markets Inc., Cowen and Company LLC, SVB Leerink LLC and Piper Jaffray & Co., or collectively the
2019 Underwriters, pursuant to which the Company granted to the 2019 Underwriters a 30-day option to purchase up to an
additional 3.0 million shares of the Company’s common stock, or the 2019 Overallotment. The Company completed the
sale  of  23.0  million  shares,  inclusive  of  the  2019  Overallotment,  to  the  2019  Underwriters  and  that  sale  resulted  in  the
receipt  by  the  Company  of  aggregate  gross  proceeds  of  approximately  $143.8  million,  less  underwriting  discounts,
commissions and offering expenses totaling approximately $8.9 million, which resulted in net proceeds of approximately
$134.9 million.

On  November  22,  2019,  the  Company  and  KKC  entered  into  a  stock  purchase  agreement,  pursuant  to  which  the
Company sold an aggregate of approximately 2.9 million shares of its common stock at $6.96 per share for net proceeds of
approximately $20.0 million, or the Private Placement. The Private Placement closed on November 25, 2019.

On May 25, 2018, the Company completed an underwritten public offering of 12.5 million shares of common stock at
a price of $4.00 per share before  underwriting  discounts  and  commissions,  or  the  2018  Offering.  In  connection  with  the
2018 Offering, the Company entered into an underwriting agreement, or the 2018 Underwriting Agreement, with Jefferies
LLC and SVB Leerink (formerly known as Leerink Partners LLC) (together the “2018 Underwriters”) pursuant to which
the Company granted to the 2018 Underwriters a 30-day option to purchase up to an additional 1.9 million shares of the
Company’s common stock, or the 2018 Overallotment. The Company completed the sale of 14.4 million shares, inclusive
of the 2018 Overallotment, to the 2018 Underwriters, and that sale resulted in the receipt by the Company of aggregate
gross proceeds of approximately $57.5  million,  less  underwriting  discounts,  commissions  and  offering  expenses  totaling
approximately $3.7 million, which resulted in net proceeds of approximately $53.8 million.

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In June 2015, the Company sold and issued warrants to purchase 2.2 million shares of common stock. The purchase
price for the warrants was $0.125 per warrant. The warrants were exercisable for an exercise price of $13.91 per share at
any time prior to the earlier of (i) 5 years from the date of issuance or (ii) certain changes in control of the Company. In
June 2020, the warrants expired with none of the warrants exercised.

8.          EQUITY INCENTIVE PLANS

2008 Plan

The  Company  granted  options  under  its  2008  Stock  Incentive  Plan  (the  “2008  Plan”)  until  June  2014  when  it  was
terminated as to future awards, although it continues to govern the terms of options that remain outstanding under the 2008
Plan. The 2008 Plan provided for the granting of incentive and non-qualified stock options, and stock purchase rights to
employees, directors and consultants at the discretion of the Board of Directors. Stock options granted generally vest over a
period of four years from the date of grant. In connection with the Board of Directors and stockholders’ approval of the
2014 Plan, all remaining shares available for future award under the 2008 Plan were transferred to 2014 Plan, and the 2008
Plan was terminated.

2014 Plan

The 2014 Equity Incentive Award Plan (the “2014 Plan”) became effective on June 18, 2014. Under the 2014 Plan,
1,419,328 shares of common stock were initially reserved for issuance pursuant to a variety of stock-based compensation
awards, including stock options, stock appreciation rights, or SARs, restricted stock awards, service-based restricted stock
unit (“RSU”) awards, performance-based restricted stock unit (“PRSU”) awards, deferred stock awards, deferred stock unit
awards, dividend equivalent awards, stock payment awards and performance awards. In addition, 35 thousand shares that
had been available for future awards under the 2008 Plan as of June 18, 2014, were added to the initial reserve available
under the 2014 Plan, bringing the total reserve upon the effective date of the 2014 Plan to 1.5 million shares. The number
of  shares  initially  reserved  for  issuance  or  transfer  pursuant  to  awards  under  the  2014  Plan  will  be  increased  by  (i)  the
number of shares represented by awards outstanding under 2008 Plan on June 18, 2014, that are either forfeited or lapse
unexercised  or  that  are  repurchased  for  the  original  purchase  price  thereof,  up  to  a  maximum  of  1.2  million  shares,  and
(ii) if approved by the Administrator of the 2014 Plan, an annual increase on the first day of each fiscal year ending in 2024
equal to the lesser of (A) four percent (4.0%) of the shares of stock outstanding (on an as converted basis) on the last day of
the  immediately  preceding  fiscal  year  and  (B)  such  smaller  number  of  shares  of  stock  as  determined  by  our  board  of
directors; provided, however, that no more than 10.7 million shares of stock may be issued upon the exercise of incentive
stock options.

2016 Plan

In November 2016, the Company’s board of directors approved the 2016 Employment Commencement Incentive Plan
(the “Inducement Plan”) under which 1.0 million shares were reserved. As of December 31, 2020, 0.4 million shares of the
Company’s common stock were subject to inducement grants that were issued pursuant to the Inducement Plan.

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Stock Plan Activity

The  following  table  summarizes  activity  under  the  2008  Plan  and  the  2014  Plan,  including  grants  issued  to

nonemployees, in the year ended December 31, 2020:

Options Issued and Outstanding

Shares Available
for Grant

Number of Shares

     Weighted-Average
Exercise Price per
Share

Weighted
Average
Remaining

Aggregate

     Contractual Term Intrinsic Value
(in thousands)

(in Years)

Balance at December 31, 2019

Options authorized
Options granted
Options exercised
Options canceled
Issuance of common stock for
services
Forfeitures of PRSUs granted in
prior years

Balance at December 31, 2020

Vested and expected to vest at
December 31, 2020
Exercisable at December 31, 2020

1,196,746  
3,552,709  
(3,727,947) 
—  
764,724  

7,272,768

$
— $
3,727,947
$
(445,942) $
(764,724) $

(42,403)

—

13,229  
1,757,058  

—
9,790,049

9,790,049
5,230,640

$

$
$

6.55
—
6.89
2.29
8.03

—

—
6.76

6.76
7.53

7.44

7.44
6.23

$

$
$

12,797

12,797
7,765

The aggregate intrinsic value represents the difference between the total pre-tax value (i.e., the difference between the
Company’s  stock  price  and  the  exercise  price)  of  stock  options  outstanding  as  of  December  31,  2020,  based  on  the
Company’s common stock closing price of $6.47 per share, which would have been received by the option holders had all
their in-the-money options been exercised as of that date.

The intrinsic value of options exercised during the years ended December 31, 2020, 2019 and 2018, was $2.7 million,

$0.4 million, and zero, respectively.

The weighted-average grant-date estimated fair value of options granted during the years ended December 31, 2020,
2019 and 2018 was $4.82, $1.79 and $4.29 per share, respectively. The estimated grant date fair value of employee stock
options  was  calculated  using  the  Black-Scholes  option-pricing  model,  based  on  the  following  weighted-average
assumptions:

Expected term (years)
Expected volatility
Risk-free interest rate
Dividend yield

Year Ended
December 31, 

2020

6.00  

83 %  
1.07 %  
— %  

Expected  Term—The  Company  has  limited  historical  information  to  develop  reasonable  expectations  about  future
exercise patterns and post-vesting employment termination behavior for its stock-option grants. As such, the expected
term  was  estimated  using  the  simplified  method  whereby  the  expected  term  equals  the  arithmetic  average  of  the
vesting term and the original contractual term of the option.

Expected Volatility—Since  January  1,  2017,  the  Company  has  used  the  historic  volatility  of  its  own  stock  over  the
retrospective period corresponding to the expected remaining term of the options, or the period since its shares were
first quoted on The Nasdaq Global Market, if that is shorter, to compute its expected stock price volatility.

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Risk-Free Interest Rate—The risk-free interest rate assumption is based on the zero-coupon U.S. treasury instruments
on the date of grant with a maturity date consistent with the expected term of the Company’s stock option grants.

Dividend Yield—To date, the Company has not declared or paid any cash dividends and does not have any plans to do
so in the future. Therefore, the Company used an expected dividend yield of zero.

Restricted Stock Units

The  following  table  summarizes  restricted  stock  unit  activity  under  the  2014  Plan  in  the  year  ended  December  31,
2020,  and  includes  restricted  stock  units  with  time  or  service-based  vesting  and  those  restricted  stock  units  with
performance-based vesting:

     Weighted-

Non-vested restricted stock units at December 31, 2019

Granted
Vested
Forfeited

Non-vested restricted stock units at December 31, 2020

— $
$
— $
— $
$

  158,626

  158,626

Number of
RSUs

Weighted-Average
Grant Date Fair
Value Per Share

Average Grant 
Date Fair Value 
Per Share

Number of
PRSUs
$
849,757
30,000
$
(866,528) $
(13,229) $
— $

—  
5.64  
—  
—  
5.64  

4.30
7.58
4.41
4.30
—

In  July  2018,  the  Company  granted  0.9  million  PRSUs  to  its  employees  that  vest  upon  the  achievement  of  certain
performance  conditions,  subject  to  the  employees’  continued  service  relationship  with  the  Company  through  the
achievement date. During 2020, the Company granted an additional 30 thousand PRSUs subject to the same performance
conditions. All 0.9 million of these PRSUs vested in September 2020. None of these PRSUs vested during the years ended
December  31,  2019  or  2018.  The  Company  recognized  $1.2  million  and  zero  of  related  expense  during  the  year  ended
December 31, 2020 and 2019, respectively.

The Company recognized $30 thousand, $0.3 million and $0.9 million of RSU related expense during the year ended
December  31,  2020,  2019  and  2018,  respectively.  The  total  estimated  fair  value  of  RSUs  vested  during  the  years  ended
December 31, 2020, 2019 and 2018 was zero, $0.2 million and $0.6 million, respectively.

Issuance of Common Stock for Services

During  the  years  ended  December  31,  2020,  2019  and  2018,  the  Company  issued  approximately  42  thousand,  113
thousand  and  75  thousand  shares,  respectively,  of  common  stock  to  members  of  the  board  of  directors  who  elected  to
receive stock in lieu of their cash fees under the Company’s Non-Employee Director Compensation Program. The shares
issued during the years ended December 31, 2020, 2019 and 2018 were valued at $0.3 million for each year, respectively,
based on the fair value of the common stock on the date of grant.

Employee Stock Purchase Plan

The  Company  adopted  the  2014  Employee  Stock  Purchase  Plan  (“ESPP”)  and  initially  reserved  approximately  0.2
million shares of common stock as of its effective date of June 18, 2014. If approved by the Administrator of the ESPP, on
the first day of each calendar year, ending in 2024, the number of shares in the reserve will increase by an amount equal to
the lesser of (i) one percent (1.0%) of the shares of common stock outstanding on the last day of the immediately preceding
fiscal year and (ii) such number of shares of common stock as determined by the board of directors; provided, however, no
more than 2,230,374 shares of our common stock may be issued under the ESPP.

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The following table summarizes ESPP activity in the year ended December 31, 2020:

Balance at December 31, 2019

Shares purchased

Balance at December 31, 2020

     Shares Available      Number of Shares     Purchase Price    

for Grant

Purchased

per Share

Gross Proceeds
(in thousands)

519,578  
(169,931)
349,647  

491,680
169,931
661,611

$

4.91

$

834

The following table illustrates the weighted-average assumptions for the Black-Scholes option-pricing model used in

determining the fair value of ESPP purchase rights granted to employees:

Expected term (years)
Expected volatility
Risk-free interest rate
Dividend yield

Stock-based Compensation

Total stock-based compensation recognized was as follows (in thousands):

Research and development
General and administrative

Total

Year Ended
December 31, 

2020

0.5  
79.4 %  
0.48 %  
— %  

Year Ended December 31, 
2019
$ 4,104
  5,832
$ 9,936

2020
$ 4,061
6,522
$ 10,583

2018
$ 3,666
5,560
$ 9,226

At  December  31,  2020,  the  Company  had  total  unrecognized  stock-based  compensation  expense,  net  of  estimated

forfeitures, of the following (dollars in thousands): 

Stock options grant
RSU grants
ESPP

At December 31, 2020

Unrecognized
Compensation
Expense

$
$
$

17,662
860
108

Average
Remaining
Vesting Period
(Years)
2.8
3.9
0.1

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9.           PROPERTY AND EQUIPMENT

Property and equipment consist of the following (in thousands):

Laboratory equipment
Office equipment and furniture
Leasehold improvements

Property and equipment, gross
Less: accumulated depreciation

Total property and equipment, net

December 31, 

$

2020
7,268
1,133
7,985
  16,386
  (14,450)
1,936
$

$

2019
7,243
870
7,949
  16,062
  (12,626)
3,436
$

Depreciation  expense  totaled  $1.8  million,  $2.5  million,  and  $2.7  million  for  the  years  ended  December  31,  2020,

2019 and 2018, respectively.

10.

ACCRUED EXPENSES AND OTHER CURRENT LIABILITIES

Accrued expenses and other current liabilities consist of the following (in thousands):

Accrued clinical expenses
Accrued contract manufacturing expenses
Derivative liability for exit fee
Accrued sales and marketing expenses
Accrued professional and consulting services
Accrued regulatory services
Other

December 31, 

2020

2019

$

$

2,197
1,840
1,376
593
243
123
285
6,657

$

$

3,451
1,414
969
122
201
342
749
7,248

11.

LEASES

The  Company  has  recorded  right-of-use  operating  lease  assets  under  three  lease  agreements.  The  Company  has
evaluated  its  facility  leases  and  determined  that,  effective  upon  the  adoption  of  Topic  842,  the  leases  evaluated  are  all
operating  leases.  The  Company  has  performed  an  evaluation  of  its  other  contracts  with  suppliers  and  collaborators  in
accordance with Topic 842 and has determined that, except for the facility leases described below, none of the Company’s
contracts contain a lease.

The Company has recorded a right-of-use operating lease asset located in Fremont, California under a lease agreement
entered into in September 2008 that was amended in December 2012 to extend the lease agreement to September 2016. In
September 2014, the Company signed the second amendment to its facility lease agreement to add space and to extend the
lease term through September 2019. In May 2016, the Company signed a third amendment to its facility lease agreement in
Fremont,  California  to  add  space  and  to  extend  the  lease  term  through  September  2021  (the  “Third  Amendment”).  The
office space consists of 72,500 square feet, that includes an additional 10,716 square feet added in September 2019, with
the entire lease terminating in September 2021. The Company will not exercise its option to renew the lease at our current
Fremont location and expect to enter into a new facility lease in Fremont, California during the first quarter of 2021.

The  Company  has  recorded  a  right-of-use  operating  lease  asset  located  in  Waltham,  Massachusetts  under  a  lease
agreement  entered  into  in  October  2018.  The  office  space  consists  of  3,520  square  feet  with  the  lease  terminating  in
September 2021. We have not renewed the lease at our current Waltham, Massachusetts facility. During December 2020,
we  entered  into  a  new  lease  agreement  for  a  different  location  in  Waltham,  Massachusetts  which  has  an  expected  lease
commencement date in April 2021.

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The  Company  has  recorded  a  right-of-use  operating  lease  asset  located  in  Milwaukee,  Wisconsin  under  a  lease
agreement entered into in October 2020 with a lease commencement date in November 2020. The office space consists of
4,768 square feet with the lease terminating in February 2026. The Company has an option to extend the lease term by one
five-year period. This option to extend the lease term has not been included in the calculation since currently the exercise
of the option is uncertain and therefore deemed not probable. The Company recorded a $0.4 million right-of use asset and
lease liability for the Milwaukee lease upon commencement of the lease.

All of the Company’s leases are operating leases and each contain customary rent escalation clauses. Certain of the
leases have both lease and non-lease components. The Company has elected to account for each separate lease component
and  the  non-lease  components  associated  with  that  lease  component  as  a  single  lease  component  for  all  classes  of
underlying assets. As of December 31, 2020, the weighted average discount rate used for the calculations was 11.7% and
the weighted average remaining lease term was 1.5 years.

The following table provides additional details of the leases presented in the balance sheets (dollars in thousands):

Facilities

Right-of-use assets

Current portion of lease liabilities
Operating lease liability, net of current portion

Total

Weighted-average remaining life (years)
Weighted-average discount rate

$

$

2,274

2,117
413
2,530

1.50
11.7 %

The lease costs, which are included in operating expenses in our statements of operations, were as follows (in

thousands):

Operating lease expense
Cash paid for operating lease

Year Ended December 31, 
2019
2020

$
$

2,608
3,065

$
$

2,592
2,645

The  following  table  summarizes  the  Company’s  undiscounted  cash  payment  obligations  for  its  operating  lease

liabilities as of December 31, 2020 (in thousands):

Ending December 31, 
2021
2022
2023
2024
2025
Thereafter
Total undiscounted operating lease payments
Imputed interest expenses

Total operating lease liabilities

Less: Current portion of operating lease liability
Operating lease liability, net of current portion

$

$

2,280
104
111
115
119
20
2,749
(219)
2,530
2,117
413

Rent expense under operating leases was $2.6 million, $2.6 million and $1.8 million for the years ended December 31,

2020, 2019 and 2018, respectively.

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12.          COLLABORATION AND LICENSING AGREEMENTS

Kyowa Kirin Co., Ltd. (2019 KKC Agreement)

In  November  2019,  the  Company  entered  into  a  research  collaboration  and  option  agreement  with  KKC  (“the  2019
KKC Agreement”), to undergo research to identify two pre-clinical study-ready compounds for designation as development
compounds, with one compound inhibiting the first undisclosed target (“Program 1”) and a second inhibiting the second
undisclosed target (“Program 2”). Pursuant to the 2019 KKC Agreement, upon completion of the research and designation
by the research steering committee of one or more development candidates (“DCs”), KKC has the right to execute one or
more separate collaborative agreements relating to the development and commercialization of one or both DCs in certain
specified territories.

Under  the  terms  of  the  2019  KKC  Agreement,  KKC  agreed  to  pay  the  Company  a  non-refundable,  non-creditable
upfront  fee  of  $10.0  million,  which  was  payable  as  follows:  the  first  installment  of  $5.0  million  within  30  days  of  the
Effective Date, and the second installment of $5.0 million on the first anniversary of the Effective Date, unless the 2019
KKC  Agreement  was  earlier  terminated  by  KKC  due  to  material  breach  by  the  Company.  The  term  of  the  2019  KKC
Agreement commenced on November 11, 2019 (“the Effective Date”) and ends on the earliest of: (a) two years following
the Effective Date, or (b) the nomination of a program DC for both programs, (c) or the nomination of one program DC
and the decision by the parties to cease research for the other program, (d) or the decision by the parties to cease research
for both programs. The Company assessed the 2019 KKC Agreement in accordance with ASC 606 and concluded that the
contract’s  counterparty,  KKC,  is  a  customer.  Management  also  considered  the  modification  guidance  prescribed  in  ASC
606  and  concluded  that  the  2019  KKC  Agreement  should  be  accounted  for  as  a  separate  contract  from  the  2017  KKC
Agreement, as defined and discussed below.

The  Company  identified  various  promises  in  the  2019  KKC  Agreement,  including  the  grant  of  an  initial  research
license,  the  Program  1  research,  the  Program  2  research,  the  right  to  obtain  certain  development  and  commercialization
rights with Program 1 in certain territories and the right to obtain development and commercialization rights with Program
2  in  certain  territories,  and  participation  in  a  joint  steering  committee    (“the  JSC”)  and  determined  that  KKC  could  not
benefit  from  either  of  the  research  programs  without  the  research  license  and  participation  in  the  JSC.  As  such,  the
combined  license,  research  programs  and  participation  in  the  JSC  were  deemed  to  be  the  highest  level  of  goods  and
services that can be deemed distinct for each of the Program 1 research and Program 2 research. The Company concluded
that the options to obtain additional development and commercialization rights that are exercisable by KKC under certain
circumstances are not performance obligations of the contract at inception because the option fees reflect the standalone
selling price of the options, and therefore, the options are not considered to be material rights.

At the outset of the 2019 KKC Agreement, the Company determined that the initial transaction price is $10.0 million
and that revenue associated with the combined performance obligations will be recognized as services are provided using
the  input  method.  Since  transfer  of  control  occurs  over  time,  in  management’s  judgment  this  input  method  is  the  best
measure of progress towards satisfying the performance obligations and reflects a faithful depiction of the transfer of goods
and  services.  Revenue  will  be  recognized  over  the  Program  1  and  Program  2  research  periods.  Management  will  re-
evaluate  the  estimates  related  to  the  transaction  price  at  the  end  of  each  reporting  period  and  as  uncertain  events  are
resolved or other changes in circumstances occur and adjust the timing of revenue recognition as necessary.

During  the  years  ended  December  31,  2020  and  2019,  the  Company  recognized  $5.4  million  and  $0.5  million,
respectively,  as  revenue  under  the  2019  KKC  Agreement  in  the  statement  of  operations  and  comprehensive  loss.  The
aggregate amount of the transaction price allocated to the Company’s partially unsatisfied performance obligations as of
December 31, 2019 was $9.5 million, of which $4.5 million was presented in the balance sheet as deferred revenue for the
respective period. As of December 31, 2020, the Company expects to recognize the remaining transaction price allocated to
the  Company’s  partially  unsatisfied  performance  obligations  over  the  remaining  research  terms,  which  are  currently
expected to extend through the end of 2021.

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Xuanzhu (HK) Biopharmaceutical Limited, or XuanZhu

In  November  2019,  the  Company  entered  into  a  license  agreement  with  XuanZhu  (“the  XuanZhu  Agreement  for  a
license  to  certain  specific  patent  and  patent  applications.  The  Company  assessed  these  arrangements  in  accordance  with
ASC  606  and  concluded  that  the  contract  counterparty,  XuanZhu,  is  a  customer.  Under  the  terms  of  the  XuanZhu
Agreement, the Company recognized $1.5 million in license fees when the agreement was executed, of which, $0.8 million
was received upfront in November 2019 and achievement for the second $0.8 million payment was determined to be not
materially at risk and probable of achievement and it was included in the transaction price and the amount was not probable
of  revenue  reversal.  Based  on  the  Company’s  assessment,  it  identified  that  it  has  one  combined  performance  obligation,
which is the license and the specific patent grant.

In  addition  to  the  license  fee  of  $1.5  million,  the  Company  may  be  entitled  to  receive  milestone  payments.  The
variable consideration related to the remaining milestone payments has not been included in the transaction price as these
were fully constrained at December 31, 2019.

For the years ended December 31, 2020 and 2019, zero and $1.5 million, respectively, of license revenue was recorded

with no cost of revenue related to the XuanZhu Agreement.

2017 KKC Agreement

In  November  2017,  the  Company  entered  into  an  exclusive  license  agreement  with  KKC,  or  the  2017  KKC
Agreement, for the development, commercialization and distribution of tenapanor in Japan for cardiorenal indications. The
Company granted KKC an exclusive license to develop and commercialize certain NHE3 inhibitors including tenapanor in
Japan  for  the  treatment  of  cardiorenal  diseases  and  conditions,  excluding  cancer.  The  Company  retained  the  rights  to
tenapanor outside of Japan, and also retained the rights to tenapanor in Japan for indications other than those stated above.
Pursuant  to  the  License  Agreement,  KKC  is  responsible  for  all  of  the  development  and  commercialization  costs  for
tenapanor in treatment of cardiorenal diseases and conditions, excluding cancer in Japan. Under the 2017 KKC Agreement,
the  Company  is  responsible  for  supplying  the  tenapanor  drug  product  for  KKC’s  use  in  development  and  during
commercialization until KKC has assumed such responsibility. Additionally, the Company is responsible for supplying the
tenapanor  drug  substance  for  KKC’s  use  in  development  and  commercialization  throughout  the  term  of  the  2017  KKC
Agreement,  provided  that  KKC  may  exercise  an  option  to  manufacture  the  tenapanor  drug  substance  under  certain
conditions

The Company assessed these arrangements in accordance with ASC 606 and concluded that the contract counterparty,
KKC, is a customer. Under the terms of the 2017 KKC Agreement, the Company received $30.0 million in up-front license
fees which was recognized as revenue when the agreement was executed. Based on the Company’s assessment, it identified
that  the  license  and  the  manufacturing  supply  services  were  its  material  performance  obligations  at  the  inception  of  the
agreement, and as such each of the performance obligations are distinct. Additionally, on January 1, 2018, the Company
recorded  unbilled  revenue  under  current  assets  of  $5.0  million  and  an  increase  in  uncharged  license  fees  under  current
liabilities  of  $1.0  million  related  to  the  first  milestone  under  the  2017  KKC  Agreement  that  KKC  achieved  in  February
2019, reflecting revenues and cost of revenue, respectively, that would have been recognized in the fourth quarter 2017 if
the Company had adopted ASC 606 prior to January 1, 2018. On KKC’s achievement of the milestone in February 2019,
the  balance  related  to  unbilled  revenue  was  adjusted  to  zero.  Correspondingly,  the  $1.0  million  balance  related  to
uncharged license fees that the Company owed to AstraZeneca was reclassified to accounts payable during the first quarter
of 2019, and subsequently paid to AstraZeneca during the second quarter of 2019.

In addition to the up-front license fee received of $30.0 million, the Company may be entitled to receive up to $55.0
million  in  total  development  milestones,  of  which  $5.0  million  has  been  received  to  date,  8.5  billion  Japanese  yen  for
commercialization  milestones,  or  approximately  $82.4  million  at  the  currency  exchange  rate  on  December  31,  2020,  as
well as reimbursement of cost, plus a reasonable overhead for the supply of product and high-teen royalties on net sales
throughout the term of the agreement. The variable consideration related to the remaining development milestone payments
has not been included in the transaction price as these were fully constrained at December 31, 2020 and 2019.

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For the years ended December 31, 2020, 2019 and 2018, $1.4 million, $0.3 million, and $0.3 million, respectively, of
product supply revenue was recorded for manufacturing supply of tenapanor and other materials to KKC for its product
development  and  clinical  trials  in  Japan,  in  accordance  with  the  Company’s  agreement  with  KKC, and  for  each  period,
negligible cost of revenue was recorded pursuant to the AstraZeneca Termination Agreement.

Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. , or Fosun Pharma

In  December  2017,  the  Company  entered  into  an  exclusive  license  agreement  with  Fosun  Pharma,  or  the  Fosun
Agreement,  for  the  development,  commercialization  and  distribution  of  tenapanor  in  China  for  both  hyperphosphatemia
and irritable bowel syndrome with constipation, or IBS-C. The Company assessed these arrangements in accordance with
ASC  606  and  concluded  that  the  contract  counterparty,  Fosun  Pharma,  is  a  customer.  Under  the  terms  of  the  Fosun
Agreement,  the  Company  received  $12.0  million  in  up-front  license  fees  which  was  recognized  as  revenue  when  the
agreement was executed. Based on the Company’s assessment, it identified that the license and the manufacturing supply
services were its material performance obligations at the inception of the agreement, and as such each of the performance
obligations are distinct.

In addition, the Company may be entitled to additional development and commercialization milestones of up to $110.0
million, as well as reimbursement of cost plus a reasonable overhead for the supply of product and tiered royalties on net
sales  ranging  from  the  mid-teens  to  20%.  The  variable  consideration  related  to  the  remaining  development  milestone
payments has not been included in the transaction price as these were fully constrained at December 31, 2019.

For the year ended December 31, 2019, $3.0 million revenue was recorded towards achievement of a milestone related

to the Fosun Agreement, and for the years ended December 31, 2020 and 2018, no revenue was recorded.

Knight Therapeutics, Inc. , or Knight   

In  March  2018,  the  Company  entered  into  an  exclusive  license  agreement  with  Knight  Therapeutics,  Inc.,  or  the
Knight  Agreement,  for 
in  Canada  for
the  development,  commercialization  and  distribution  of 
hyperphosphatemia  and  IBS-C.  The  Company  assessed  these  arrangements  in  accordance  with  ASC  606  and  concluded
that the contract counterparty, Knight, is a customer. Based on the Company’s assessment, it identified that the license and
the manufacturing supply services were its material performance obligations at the inception of the agreement, and as such
each of the performance obligations are distinct.

tenapanor 

Under the terms of the agreement, the Company is eligible to receive up to CAD 25.0 million in total payments, or
$19.6 million at the currency exchange rate on December 31, 2020, including an up-front payment and development and
sales milestones, reimbursement of supply costs on a schedule specifying cost per tablet, with a reasonable mark up for
overhead, as well as tiered royalty rates on net sales ranging from the mid-single digits to the low twenties. The variable
consideration related to the remaining development milestone payments has not been included in the transaction price as
these were fully constrained at December 31, 2020.

For the years ended December 31, 2020, 2019 and 2018, $0.7 million, zero and $2.3 million of revenue was recorded,
respectively, related to the Knight Agreement. For the year ended December 31, 2020, $0.1 million product supply revenue
was recorded related to the Knight Agreement. There was no product revenue related to the Knight Agreement in 2019 or
2018.  Pursuant  to  the  AstraZeneca  Termination  Agreement,  $0.1  million,  zero  and  $0.5  million  of  cost  of  revenue  was
recorded during 2020, 2019 and 2018, respectively.

AstraZeneca

In June 2015, the Company entered into a termination agreement with AstraZeneca, or the AstraZeneca Termination
Agreement,  pursuant  to  which  the  Company  remains  liable  to  pay  AstraZeneca  license  fees  for  (i)  future  royalties  at  a
royalty rate of 10% of net sales of tenapanor or other NHE3 products by the Company or its licensees, and (ii) 20% of non-
royalty revenue received from a new collaboration partner should the Company elect to license, or otherwise provide rights
to develop and commercialize tenapanor or certain other NHE3 inhibitors, up to a maximum of $75.0 million in

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aggregate for (i) and (ii). To date in aggregate, the Company has recognized $10.6 million of the $75.0 million, recorded as
cost of revenue, as follows (in thousands):

Cost of Revenue

Year 2017
Year 2018
Year 2019
Year 2020
Total

Maximum payment per termination agreement
Remaining potential commitment
_______________________

     Recognized      Amount Paid
6,000
9,400 * $
  $
2,864
1,002
742
10,608
75,000
64,392

466
600
145
10,611

$

$

$

* Includes the $1,000 adjustment recorded pursuant to the adoption of ASC 606, as discussed in Note 2.

13.         INCOME TAXES

The  components  of  the  provision  for  income  taxes  for  the  year  ended  December  31,  2020,  2019  and  2018,  are  as

follows (in thousands):

     Year Ended December 31, 
     2020      2019     
2018

Current:
State
Foreign

Total current

Deferred:
Federal

Total deferred

Provision for income taxes

$

2

2
$
  —   301
  303

2

4
$
  —
4

  —   —   —
  —   —   —
4
$ 303
$

2

$

The following is a reconciliation of the statutory federal income tax rate to the Company’s effective tax rate:

Year Ended December 31, 

Change in valuation allowance
Income tax at the federal statutory rate
Tax credits
State taxes, net of federal benefit
Stock based compensation
Other

Income tax provision

     2020     

2019     

(22.3)%   (21.9)%  
21.0
1.3  
0.7  
(0.1)
(0.6) 

2018
(22.5)%
21.0
1.4
0.6
(1.2)
0.7

21.0
1.6  
0.3  
(0.9)
(0.4) 
(0.3)%   — %

— %  

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Deferred  income  taxes  reflect  the  tax  effects  of  temporary  differences  between  the  carrying  amounts  of  assets  and
liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the
Company’s deferred tax assets are as follows as of December 31, 2020 and 2019 (in thousands):

December 31, 

2020

2019

Deferred tax assets:

Amortization and depreciation
Net operating loss carryforwards
Tax credits
Stock-based compensation
Lease obligation
Other

Gross deferred tax assets

Valuation allowance

Deferred tax assets net of valuation allowance

Deferred tax liabilities
Right-of-use asset
Revenue recognition
Other

Net deferred tax assets

$

$

51,370
53,436
11,777
5,524
1,804

—  

123,911
(123,402)
509

$

45,555
40,896
10,136
4,853
984
940
103,364
  (102,344)
1,020

(479)
—
(30)
— $

(834)
(158)
(28)
—

Realization of deferred tax assets is dependent on future taxable income, if any, the timing and the amount of which
are  uncertain.  The  Company  assesses  the  available  positive  and  negative  evidence  to  estimate  whether  sufficient  future
taxable income will be generated to permit use of the existing deferred tax assets. A significant component of objective
negative evidence evaluated was the Company’s cumulative loss incurred over the three-year period ended December 31,
2020. Such objective evidence limits the ability to consider other subjective evidence, such as our projections for future
growth.  On  the  basis  of  this  evaluation,  as  of  December  31,  2020,  December  31,  2019  and  December  31,  2018,  a  full
valuation  allowance  has  been  recorded  against  Company’s  net  deferred  tax  asset.  The  amount  of  the  deferred  tax  asset
considered realizable, however, could be adjusted if estimates of future taxable income during the carryforward period are
reduced or increased or if objective negative evidence in the form of cumulative losses is no longer present and additional
weight is given to subjective evidence such as our projections for growth.

As  of  December  31,  2020,  the  Company  had  net  operating  loss  carryforwards  for  federal  income  tax  purposes  of
approximately  $287.9  million,  of  which  approximately  $151.0  million  can  be  carried  forward  indefinitely  and  the
remaining  net  operating  losses  expire  beginning  in  2030,  if  not  utilized.  Federal  research  and  development  tax  credit
carryforwards  of  approximately  $13.5  million  that  expire  beginning  in  2027,  if  not  utilized,  and  foreign  tax  credit
carryforwards of approximately $1.2 million that expire in 2027, if not utilized.

In addition, the Company had net operating loss carryforwards for California income tax purposes of approximately
$88.3 million that expire beginning of 2030, if not utilized, and state research and development tax credit carryforwards of
approximately  $7.4  million  which  can  be  carried  forward  indefinitely.  The  Company  had  approximately  $0.1  million  of
minimum tax credit carryovers for California income tax purposes. The minimum tax credits have no expiration date. The
Company had other state net operating losses of approximately $1.9 million that begin to expire in 2035.

The  future  utilization  of  net  operating  loss  and  tax  credit  carryforwards  and  credits  may  be  subject  to  an  annual
limitation,  pursuant  to  Internal  Revenue  Code  Sections  382  and  383,  as  a  result  of  ownership  changes  that  may  have
occurred previously or that could occur in the future. Due to the existence of the valuation allowance, limitations under
Section 382 and 383 will not impact the Company’s effective tax rate.

On March 27, 2020, the Coronavirus Aid, Relief, and Economic Security Act (“CARES Act”) was enacted and signed
into law in response to coronavirus disease 2019 (“COVID-19”). The CARES Act, among other things, included several
significant  provisions  that  impacted  corporate  taxpayers’  accounting  for  income  taxes.  Prior  to  the  enactment  of  the
CARES Act, the 2017 Tax Cuts and Jobs Act generally eliminated the ability to carryback net operating losses (“NOLs”),

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and permitted the NOLs arising in tax years beginning after December 31, 2017 to be carried forward indefinitely, limited
to  80%  of  the  taxpayer’s  income.  The  CARES  Act  amended  the  NOL  rules,  suspending  the  80%  limitation  on  the
utilization of NOLs generated after December 31, 2017 and before January 1, 2021. Additionally, the CARES Act allows
corporate NOLs arising in taxable years beginning after December 31, 2017 and before January 1, 2021, to be carried back
to each of the five taxable years preceding the taxable year of the loss. Also, the CARES Act allows companies to defer
making  certain  payroll  tax  payments  until  future  years.  With  the  enactment  of  the  CARES  Act,  the  company  does  not
expect a financial statement impact from income taxes.

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

Balance at beginning of year
Additions (subtractions) based on tax positions related to prior
year
Additions based on tax positions related to current year

Balance at end of year

2020
$ 24,538

December 31, 
2019
$ 23,052

2018
$ 20,734

(1,388)
474
$ 23,624

755
731
$ 24,538

1,634
684
$ 23,052

The Company recognizes a tax benefit from an uncertain tax position when it is more likely than not that the position
will  be  sustained  upon  examination,  including  resolutions  of  any  related  appeals  or  litigation  processes,  based  on  the
technical merits. Income tax positions must meet a more likely than not recognition at the effective date to be recognized.
The  unrecognized  tax  benefits,  if  recognized  and  in  absence  of  full  valuation  allowance,  would  impact  the  income  tax
provision by $13.3 million, $13.2 million, and $9.8 million as of December 31, 2020, 2019 and 2018, respectively.

The  Company  has  elected  to  include  interest  and  penalties  as  a  component  of  tax  expense.  During  the  years  ended
December 31, 2020, 2019 and 2018, the Company did not recognize accrued interest and penalties related to unrecognized
tax benefits. Although the timing and outcome of an income tax audit is highly uncertain, the Company does not anticipate
that the amount of existing unrecognized tax benefits will significantly change during the next 12 months.

The  Company  files  income  tax  returns  in  the  U.S.  federal,  Arizona,  California,  Colorado,  DC,  Florida,  Georgia,
Illinois,  Indiana,  Massachusetts,  Michigan,  New  York,  New  York  MTA,  Oregon,  Tennessee,  Texas  and  Wisconsin  tax
jurisdictions. Due to the Company’s net operating loss and tax credit carryforwards, the income tax returns remain open to
U.S. federal and state tax examinations. The Company is not currently under examination in any tax jurisdiction.

14.        GEOGRAPHIC INFORMATION AND CONCENTRATIONS

Revenue by geographic areas for the years ended December 31, 2020, 2019 and 2018, are as follows (in thousands):

Year Ended December 31, 
2019

2018

2020

United States
International:

North America (1)
Asia Pacific (2) (3) (4)

Total revenue

$ — $ — $

—

806
  6,765
$ 7,571

  —  
  5,281
$ 5,281

2,320
287
$ 2,607

(1) Revenues  from  North  America  are  comprised  of  amounts  earned  from  Canada  in  accordance  with  the  Knight

Agreement.

(2) Revenues from Asia Pacific in 2020 are comprised of amounts earned from Japan in accordance with the 2017 KKC

Agreement and 2019 KKC Agreement.

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(3)   Revenues from Asia Pacific in 2019 were comprised of $0.8 million from Japan in accordance with the 2017 KKC
Agreement and 2019 KKC Agreement, $1.5 million from Hong Kong in accordance with the XuanZhu Agreement and
$3.0 million from China in accordance with the Fosun Agreement.

(4)  Revenues from Asia Pacific in 2018 were comprised of amounts earned from Japan in accordance with the 2017 KKC

Agreement.

Revenues are attributed to geographical areas based on the domicile of the Company’s collaboration partners.

Revenues  recorded  in  the  years  ended  December  31,  2020,  2019  and  2018,  were  wholly  from  collaboration
partnerships. Collaboration partnerships accounting for more than 10% of total revenues during the years ended December
31, 2020, 2019 and 2018 are as follows:

Year Ended December 31, 

     2020     

2019     

2018  

KKC
Knight
Fosun Pharma
XuanZhu

15.         NET LOSS PER SHARE

89 %  
15 %  
11 %   — %  

11   %
89 %  
57 %   — %
28 %   — %  

- %  
- %  

Basic  net  loss  per  share  is  calculated  by  dividing  net  loss  by  the  weighted-average  number  of  common  shares
outstanding during the period, less shares subject to repurchase, and excludes any dilutive effects of stock-based awards
and  warrants.  Diluted  net  loss  per  common  share  is  computed  giving  effect  to  all  potential  dilutive  common  shares,
including common stock issuable upon exercise of stock options, and unvested restricted common stock and stock units. As
the  Company  had  net  losses  for  the  years  ended  December  31,  2020,  2019  and  2018,  all  potential  common  shares  were
determined to be anti-dilutive. The following table sets forth the computation of net loss per common share (in thousands,
except per share amounts):

Numerator:
Net loss
Denominator:

Weighted average common shares outstanding - basic and diluted

Net loss per share - basic and diluted

$

$

Year Ended December 31, 

2020

2019

2018

(94,313) $

(94,940) $

(91,298)

89,582,138

  64,478,066

(1.05) $

(1.47) $

  56,219,919
(1.62)

For the years ended December 31, 2020, 2019 and 2018, the total numbers of securities that could potentially dilute
net income per share in the future that were not considered in the diluted net loss per share calculations because the effect
would have been anti-dilutive were as follows:

Options to purchase common stock
Warrants to purchase common stock
Restricted stock units
Performance-based restricted stock units
ESPP shares issuable
Total

Year Ended December 31, 

2020

9,246,047  
932,091  
26,121  
—  
94,466  
10,298,725  

2019

2018

7,128,247   5,378,008
2,172,899   2,172,899
199,135
395,791
63,413
10,247,413   8,209,246

—  
867,506  
78,761  

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The number of potential common shares that would have been included in diluted income per share had it not
been for the anti-dilutive effect caused by the net loss, computed by converting these securities using the treasury stock
method during the years ended December 31, 2020, 2019 and 2018, was approximately 2.1 million, 1.1 million and 1.0
million, respectively.

16.         COMMITMENTS AND CONTINGENCIES

Guarantees and Indemnifications

The Company indemnifies each of its officers and directors for certain events or occurrences, subject to certain limits,
while  the  officer  or  director  is  or  was  serving  at  our  request  in  such  capacity,  as  permitted  under  Delaware  law  and  in
accordance  with  our  certificate  of  incorporation  and  bylaws.  The  term  of  the  indemnification  period  lasts  as  long  as  an
officer  or  director  may  be  subject  to  any  proceeding  arising  out  of  acts  or  omissions  of  such  officer  or  director  in  such
capacity.

The maximum amount of potential future indemnification is unlimited; however, the Company currently holds director
and officer liability insurance, which allows the transfer of risk associated with our exposure and may enable the Company
to  recover  a  portion  of  any  future  amounts  paid.  The  Company  believes  that  the  fair  value  of  these  indemnification
obligations is minimal. Accordingly, the Company has not recognized any liabilities relating to these obligations for any
period presented.

Legal Proceedings and Claims

From  time  to  time  the  Company  may  be  involved  in  claims  arising  in  connection  with  its  business.  Based  on
information  currently  available,  management  believes  that  the  amount,  or  range,  of  reasonably  possible  losses  in
connection  with  any  pending  actions  against  the  Company  will  not  be  material  to  the  Company’s  financial  condition  or
cash flows, and no contingent liabilities were accrued as of December 31, 2020 or 2019.

17.        SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED)

Selected quarterly financial results from operations for the years ended December 31, 2020 and 2019 are as follows (in

thousands, except per share amounts):

Total revenue
Operating expenses
Net loss
Net loss per share - basic and diluted

Total revenue
Operating expenses
Net loss
Net loss per share - basic and diluted

2020 Quarter Ended

     March 31     

June 30     September 30     December 31
1,809
2,713
$
$
1,213
$ 22,982
29,452
19,874
$
$ (22,373) $ (24,956) $ (18,108) $ (28,876)
(0.32)
$

$
1,836
$ 26,043

(0.25) $

(0.20) $

(0.28) $

$
$

2019 Quarter Ended

     March 31     

— $

June 30     September 30     December 31
2,250
3,013
$
$
$ 25,498
21,098
25,102
$
$ (26,144) $ (25,467) $ (23,539) $ (19,790)
(0.27)
$

18
$ 24,846

(0.37) $

(0.42) $

(0.41) $

$
$

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND

FINANCIAL DISCLOSURE

None.

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ITEM 9A. CONTROLS AND PROCEDURES

Conclusions Regarding the Effectiveness of Disclosure Controls and Procedures

As  of  December  31,  2020,  management,  with  the  participation  of  our  Chief  Executive  Officer  and  Chief  Financial
Officer, performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures
as defined in Rules 13a-15(e) and 15d-15(e) of the Exchange Act. Our disclosure controls and procedures are designed to
ensure  that  information  required  to  be  disclosed  in  the  reports  we  file  or  submit  under  the  Exchange  Act  is  recorded,
processed,  summarized  and  reported  within  the  time  periods  specified  in  the  Securities  and  Exchange  Commission’s
rules  and  forms,  and  that  such  information  is  accumulated  and  communicated  to  our  management,  including  the  Chief
Executive Officer and the Chief Financial Officer, to allow timely decisions regarding required disclosures.

Any  controls  and  procedures,  no  matter  how  well  designed  and  operated,  can  provide  only  reasonable  assurance  of
achieving  the  desired  control  objective  and  management  necessarily  applies  its  judgment  in  evaluating  the  cost-benefit
relationship of possible controls and procedures. Based on this evaluation, our Chief Executive Officer and Chief Financial
Officer concluded that, as of December 31, 2020, the design and operation of our disclosure controls and procedures were
effective at a reasonable assurance level.

Management’s Annual Report on Internal Control Over Financial Reporting

Our  management  is  responsible  for  establishing  and  maintaining  adequate  internal  control  over  financial  reporting.
Internal  control  over  financial  reporting  is  a  process  designed  by,  or  under  the  supervision  of,  our  CEO  and  CFO,  and
effected  by  our  Board  of  Directors,  management  and  other  personnel,  to  provide  reasonable  assurance  regarding  the
reliability  of  financial  reporting  and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with
generally accepted accounting principles and includes those policies and procedures that:

● Pertain  to  the  maintenance  of  records  that  accurately  and  fairly  reflect  in  reasonable  detail  the  transactions  and
dispositions of the assets of our company;

● Provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  financial
statements  in  accordance  with  generally  accepted  accounting  principles,  and  that  our  receipts  and  expenditures  are
being made only in accordance with authorizations of our management and directors; and

● Provide  reasonable  assurances  regarding  prevention  or  timely  detection  of  unauthorized  acquisition,  use  or
disposition of our assets that could have a material adverse effect on our financial statements.

Our management assessed our internal control over financial reporting as of December 31, 2020, the end of the period
covered  by  this  Annual  Report  on  Form  10-K.  Management  based  its  assessment  on  criteria  established  in  “Internal
Control—Integrated  Framework  (2013)”  issued  by  the  Committee  of  Sponsoring  Organizations  of  the  Treadway
Commission. Based on management’s assessment of our internal control over financial reporting, management concluded
that, as of December 31, 2020, our internal control over financial reporting was effective.

Internal control over financial reporting has inherent limitations. Internal control over financial reporting is a process
that involves human diligence and compliance and is subject to lapses in judgment and breakdowns resulting from human
failures. Internal control over financial reporting also can be circumvented by collusion or improper management override.
Because of such limitations, there is a risk that material misstatements will not be prevented or detected on a timely basis
by  internal  control  over  financial  reporting.  However,  these  inherent  limitations  are  known  features  of  the  financial
reporting process. Therefore, it is possible to design into the process safeguards to reduce, though not eliminate, this risk.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the quarter ended December 31, 2020

that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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ITEM 9B. OTHER INFORMATION

None.

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ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

PART III

Information required by this item will be contained in our definitive proxy statement to be filed with the Securities and
Exchange  Commission  on  Schedule  14A  in  connection  with  our  2020  Annual  Meeting  of  Stockholders  (the  “Proxy
Statement”), which will be filed not later than 120 days after the end of our fiscal year ended December 31, 2020, under the
headings  “Executive  Officers,”  “Election  of  Directors,”  “Corporate  Governance,”  and  “  Section  16(a)  Beneficial
Ownership Reporting Compliance,” and is incorporated herein by reference.

We have adopted a Code of Business Conduct and Ethics that applies to our officers, directors and employees which is
available on our website at www.ardelyx.com. The Code of Business Conduct and Ethics is intended to qualify as a “code
of  ethics”  within  the  meaning  of  Section  406  of  the  Sarbanes-Oxley  Act  of  2002  and  Item  406  of  Regulation  S-K.  In
addition, we intend to promptly disclose (1) the nature of any amendment to our Code of Business Conduct and Ethics that
applies to our principal executive officer, principal financial officer, principal accounting officer or controller or persons
performing similar functions and (2) the nature of any waiver, including an implicit waiver, from a provision of our code of
ethics that is granted to one of these specified officers, the name of such person who is granted the waiver and the date of
the waiver on our website in the future.

ITEM 11. EXECUTIVE COMPENSATION

The  information  required  by  this  item  regarding  executive  compensation  will  be  incorporated  by  reference  to  the

information set forth in the sections titled “Executive Compensation” in our Proxy Statement.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND
RELATED STOCKHOLDER MATTERS

The information required by this item regarding security ownership of certain beneficial owners and management will
be  incorporated  by  reference  to  the  information  set  forth  in  the  section  titled  “Security  Ownership  of  Certain  Beneficial
Owners and Management” and “Equity Compensation Plan Information” in our Proxy Statement.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

The  information  required  by  this  item  regarding  certain  relationships  and  related  transactions  and  director
independence will be incorporated by reference to the information set forth in the sections titled “Certain Relationships and
Related Party Transactions” and “Election of Directors”, respectively, in our Proxy Statement.

ITEM 14. PRINCIPAL ACCOUNTING FEES AND SERVICES

The  information  required  by  this  item  regarding  principal  accountant  fees  and  services  will  be  incorporated  by
reference to the information set forth in the section titled “Principal Accountant Fees and Services” in our Proxy Statement.

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ITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES

(a) The following documents are filed as part of this report:

PART IV

1. Financial Statements

See Index to Financial Statements at Item 8 herein.

2. Financial Statement Schedules

All  schedules  are  omitted  because  they  are  not  applicable  or  the  required  information  is  shown  in  the
financial statements or notes thereto.

3. Exhibits

See the Exhibit Index immediately following this page.

ITEM 16. FORM 10-K SUMMARY

None.

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Table of Contents

Exhibit
Number

3.1

3.2

4.1

4.2

4.3

4.4

10.1

10.2

10.3(a)

10.3(b)

10.3(c)

10.3(d)

10.4(a)#

10.4(b)#

10.4(c)#

10.5(a)#

10.5(b)#

10.5(c)#

10.6#

10.7#

10.8#

10.9#

Exhibit Index

Amended and Restated Certificate of Incorporation

Exhibit Description

Amended and Restated Bylaws

Reference is made to Exhibits 3.1 and 3.2

Form of Common Stock Certificate

Form of Warrant issued pursuant to the Securities Purchase
Agreement by and among Ardelyx, Inc. and the purchasers
signatory thereto, dated June 2, 2015

Description of the Registrant’s Securities Registered Pursuant
to Section 12 of the Securities Exchange Act of 1934

Termination Agreement, dated June 2, 2015, by and between
AstraZeneca AB and Ardelyx, Inc.

Amendment No. 1 to Termination Agreement and to
Manufacturing and Supply Agreement, dated November 2,
2015 by and between AstraZeneca AB and Ardelyx, Inc.

Lease, dated August 8, 2008, by and between 34175
Ardenwood Venture, LLC and Ardelyx, Inc.

First Amendment to Lease, dated December 20, 2012, by and
between 34175 Ardenwood Venture, LLC and Ardelyx, Inc.

Second Amendment to Lease, dated September 5, 2014, by and
between Ardelyx, Inc. and 34175 Ardenwood Venture, LLC

Third Amendment to Lease, dated April 28, 2016, by and
between Ardelyx, Inc. and 34175 Ardenwood Venture, LLC

Ardelyx, Inc. 2008 Stock Incentive Plan, as amended

Form of Stock Option Grant Notice and Stock Option
Agreement under the 2008 Stock Incentive Plan, as amended

Form of Restricted Stock Purchase Grant Notice and Restricted
Stock Purchase Agreement under the 2008 Stock Incentive
Plan, as amended

Ardelyx, Inc. 2014 Equity Incentive Award Plan

Form of Stock Option Grant Notice and Stock Option
Agreement under the 2014 Equity Incentive Award Plan

Form of Restricted Stock Award Agreement and Restricted
Stock Unit Award Grant Notice under the 2014 Equity
Incentive Award Plan

Form of Indemnification Agreement for directors and officers

Amended and Restated Executive Employment Agreement,
dated June 6, 2014, by and between Ardelyx, Inc. and Michael
Raab

Amended and Restated Change in Control Severance
Agreement, dated June 6, 2014, by and between Ardelyx, Inc.
and Jeffrey Jacobs, Ph.D.

Offer Letter, dated May 2, 2008, by and between Ardelyx, Inc.
and Jeff Jacobs, Ph.D.

116

     Form     
8-K

Incorporated by Reference
Date
6/24/2014

3.1

     Number      Herewith

Filed

X

8-K

6/24/2014

3.2

S-1/A

6/18/2014

S-3

7/13/2015

4.2

4.3

10-Q

8/12/2015

10.1

10-K

3/4/2016

10.1(d)

S-1

5/19/2014

10.4(a)

S-1

5/19/2014

10.4(b)

8-K

9/9/2014

10.1

10-Q

8/8/2016

10.3

S-1

S-1

5/19/2014

10.5(a)

5/19/2014

10.5(b)

S-1

5/19/2014

10.5(c)

S-8

7/14/2014

99.3

S-1/A

6/9/2014

10.6(b)

S-1/A

6/9/2014

10.6(c)

S-1/A

S-1/A

6/9/2014

6/9/2014

10.7

10.8

S-1/A

6/9/2014

10.17

S-1/A

6/9/2014

10.12

    
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Exhibit
Number

10.10#

10.11#

Exhibit Description

Offer Letter, dated December 28, 2009, by and between
Ardelyx, Inc. and David Rosenbaum, Ph.D.

Offer Letter, dated November 21, 2012, by and between
Ardelyx, Inc. and Elizabeth Grammer, Esq.

10.12#

Ardelyx, Inc. 2014 Employee Stock Purchase Plan

10.13(a)#

Non-Employee Director Compensation Program

10.13(b)#

Description of amendments to Non-Employee Director
Compensation Program

10.14

10.15

10.16(a)#

10.16(b)#

10.16(c)#

10.16(d)#

10.17††

10.18††

10.19#

10.20#

10.21

10.22

10.23#

Registration Rights Agreement by and among Ardelyx, Inc. and
the investors signatory thereto, dated June 2, 2015

Registration Rights Agreement by and among Ardelyx, Inc. and
the investors signatory thereto, dated July 14, 2016

Ardelyx, Inc. 2016 Employment Commencement Incentive
Plan

Form of Stock Option Grant Notice and Stock Option
Agreement under the 2016 Employment Commencement
Incentive Plan

Form of Restricted Stock Unit Award Grant Notice and
Restricted Stock Unit Award Agreement under the 2016
Employment Commencement Incentive Plan

Form of Restricted Stock Award Grant Notice and Restricted
Stock Award Agreement under the 2016 Employment
Commencement Incentive Plan

License Agreement, dated November 27, 2017, by and between
Kyowa Hakko Kirin Co. , Ltd. and Ardelyx, Inc.

License Agreement, dated December 11, 2017, by and between
Shanghai Fosun Pharmaceutical Industrial Development Co.
Ltd. and Ardelyx, Inc.

Second Amended and Restated Change in Control and
Severance Agreement by and between Ardelyx, Inc. and
Elizabeth Grammer.

Second Amended and Restated Change in Control and
Severance Agreement by and between Ardelyx, Inc. and David
P. Rosenbaum, Ph.D.

Loan and Security Agreement, dated May 16, 2018, by and
between the Company and Solar Capital Ltd. and Western
Alliance Bank.

Exit Fee Agreement, dated May 16, 2018, by and between the
Company and Solar Capital Ltd. and Western Alliance Bank.  

Transition and Separation Agreement dated July 8, 2018, by
and between the Company and Reginald Seeto, MBBS.

     Form     
S-1/A

Incorporated by Reference
Date
6/9/2014

10.13

     Number      Herewith

Filed

S-1/A

6/9/2014

10.14

S-8

7/14/2014

S-1/A

8-K

6/9/2014

3/9/2017

99.6

10.21

N/A

S-3

7/13/2015

99.1

10-Q

8/8/2016

10.2

S-8

11/10/2016

99.1

S-8

11/10/2016

99.2

S-8

11/10/2016

99.3

S-8

11/10/16

99.4

10-K

3/14/2018

10.35

10-K

3/14/2018

10.36

10-Q

5/8/2018

10.0

10-Q

5/8/2018

10.1

10-Q

8/7/2018

10.1

10-Q

8/7/2018

10.2

10-Q

8/7/2018

10.3

10.24(a)#

Amended and Restated Non-Employee Director Compensation
Program.

10-Q

5/7/2019

10.1

10.25#

10.26#

Transition and Separation Agreement dated November 25,
2019, by and between the Company and Mark Kaufmann.

Offer Letter, dated April 27, 2020, by and between Ardelyx,
Inc. and Susan Rodriguez

10-K

3/6/2020

10.3

10-Q

8/6/2020

10.1

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Exhibit
Number

10.27#

10.28#

10.29#

10.30††

10.31

23.1

31.1

31.2

32.1

Exhibit Description
Change in Control Severance Agreement dated June 2, 2020, by
and between Ardelyx, Inc. and Susan Rodriguez

Offer Letter, dated June 2, 2020, by and between Ardelyx, Inc.
and Justin Renz

Change in Control Severance Agreement, dated June 8, 2020,
by and between Ardelyx, Inc. and Justin Renz

Manufacturing Services Agreement, dated May 18, 2020,
between Ardelyx, Inc. and Patheon Pharmaceuticals Inc.

Lease Agreement, dated December 30, 2020, by and between
Ardelyx, Inc. and Prospect Fifth Ave, LLC.

Consent of Independent Registered Public Accounting Firm

Certification of Principal Executive Officer Required Under
Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of
1934, as amended

Certification of Principal Financial Officer Required Under
Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of
1934, as amended

Certification of Principal Executive Officer and Principal
Financial Officer Required Under Rule 13a‑14(b) of the
Securities Exchange Act of 1934, as amended, and 18 U.S.C
§1350

101.INS

101.SCH

101.CAL

101.DEF

Inline XBRL Instance Document

Inline XBRL Taxonomy Extension Schema Document

Inline XBRL Taxonomy Extension Calculation Linkbase
Document

Inline XBRL Taxonomy Extension Definition Linkbase
Document

101.LAB

Inline XBRL Taxonomy Extension Label Linkbase Document

101.PRE

Inline XBRL Taxonomy Extension Presentation Linkbase
Document

104

Cover Page Interactive Data File

     Form     
10-Q

Incorporated by Reference
Date
8/6/2020

10.2

     Number      Herewith

Filed

10-Q

8/6/2020

10.3

10-Q

8/6/2020

10.4

10-Q

8/6/2020

10.5

X

X

X

X

X

X

X

X

X

X

X

† Confidential  treatment  granted  as  to  portions  of  this  Exhibit.  The  confidential  portions  of  this  Exhibit  have  been

omitted and are marked by asterisks.

†† Certain portions have been omitted pursuant to a confidential treatment request. Omitted information has been filed

separately with the Securities and Exchange Commission.

#

Indicates management contract or compensatory plan.

118

    
Table of Contents

Pursuant  to  the  requirements  of  the  Securities  Exchange  Act  of  1934,  the  Registrant  has  duly  caused  this  report  to  be
signed on its behalf by the undersigned, thereunto duly authorized.

SIGNATURES

Date: March 8, 2021

     Ardelyx, Inc.

By:/s/ Michael Raab
Michael Raab
President Chief Executive Officer and Director
(Principal Executive Officer)

POWER OF ATTORNEY

Each person whose individual signature appears below hereby authorizes and appoints Michael Raab and Justin Renz,
and each of them, with full power of substitution and resubstitution and full power to act without the other, as his or her
true  and  lawful  attorney-in-fact  and  agent  to  act  in  his  or  her  name,  place  and  stead  and  to  execute  in  the  name  and  on
behalf of each person, individually and in each capacity stated below, and to file any and all amendments to this annual
report on Form 10-K and to file the same, with all exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing, ratifying and confirming all that said attorneys-in-fact and agents
or any of them or their or his substitute or substitutes may lawfully do or cause to be done by virtue thereof.

119

Table of Contents

Pursuant  to  the  requirements  of  the  Securities  Exchange  Act  of  1934,  this  report  has  been  signed  below  by  the

following persons on behalf of the registrant and in the capacities and on the dates indicated.

Signature

/s/ Michael Raab
Michael Raab

/s/ Justin Renz
Justin Renz

/s/ David Mott
David Mott

/s/ Robert Bazemore
Robert Bazemore

/s/ William Bertrand, Jr.
William Bertrand, Jr.

/s/ Geoffrey A. Block
Geoffrey A. Block, M.D.

/s/ Onaiza Cadoret-Manier
Onaiza Cadoret-Manier

/s/ Jan M. Lundberg
Jan M. Lundberg, Ph.D.

/s/ Gordon Ringold
Gordon Ringold, Ph.D.

/s/ Richard Rodgers
Richard Rodgers

Title

President, Chief Executive Officer and Director
(Principal Executive Officer)

Chief Financial Officer
(Principal Financial and Accounting Officer)

Date

March 8, 2021

March 8, 2021

Chairman of the Board of Directors

March 8, 2021

March 8, 2021

March 8, 2021

March 8, 2021

March 8, 2021

March 8, 2021

March 8, 2021

March 8, 2021

Director

Director

Director

Director

Director

Director

Director

120

    
    
DESCRIPTION OF THE REGISTRANT’S
SECURITIES REGISTERED PURSUANT TO
SECTION 12 OF THE SECURITIES
EXCHANGE ACT OF 1934

Exhibit 4.4

Ardelyx, Inc. (“we,” “us,” or “our”) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as
amended: our common stock, $0.0001 par value per share (“common stock”).

Description of Capital Stock

The following summary describes our capital stock and does not purport to be complete. It is subject to and qualified in its entirety by
reference to the material provisions of our amended and restated certificate of incorporation and our amended and restated bylaws, each
of which are incorporated by reference as an exhibit to the Annual Report on Form 10-K of which this Exhibit 4.4 is a part, as well as of
the Delaware General Corporation Law. For a complete description, we encourage you to read amended and restated certificate of
incorporation, our amended and restated bylaws and the applicable provisions of the Delaware General Corporation Law for additional
information.

General

Our amended and restated certificate of incorporation authorizes 300,000,000 shares of common stock, $0.0001 par value per share,
and 5,000,000 shares of preferred stock, $0.0001 par value per share.

Common Stock

Voting Rights

Each holder of our common stock is entitled to one vote for each share on all matters submitted to a vote of the stockholders, including
the election of directors. Our stockholders do not have cumulative voting rights in the election of directors. Accordingly, holders of a
majority of the voting shares are able to elect all of the directors. In addition, the affirmative vote of holders of 66 2/3% of the voting
power of all of the then outstanding voting stock will be required to take certain actions, including amending certain provisions of our
amended and restated certificate of incorporation, such as the provisions relating to amending our amended and restated bylaws, the
classified board and director liability.

Dividends

Subject to preferences that may be applicable to any then outstanding preferred stock, holders of our common stock are entitled to
receive dividends, if any, as may be declared from time to time by our board of directors out of legally available funds.

Liquidation

In the event of our liquidation, dissolution or winding up, holders of our common stock will be entitled to share ratably in the net assets
legally available for distribution to stockholders after the payment of all of our debts and other liabilities and the satisfaction of any
liquidation preference granted to the holders of any then outstanding shares of preferred stock.

Rights and Preferences

Holders of our common stock have no preemptive, conversion, subscription or other rights, and there are no redemption or sinking fund
provisions applicable to our common stock. The rights, preferences and privileges of the holders of our common stock are subject to and
may be adversely affected by the rights of the holders of shares of any series of our preferred stock that we may designate in the future.

Fully Paid and Nonassessable.

All of our outstanding shares of common stock are, and the shares of common stock to be issued in this offering will be, fully paid and
nonassessable.

Preferred Stock – Limitations on Rights of Holders of Common Stock

Our board of directors has the authority, without further action by our stockholders, to issue up to 5,000,000 shares of preferred stock in
one or more series and to fix the rights, preferences, privileges and restrictions thereof. These rights, preferences and privileges could
include dividend rights, conversion rights, voting rights, terms of redemption, liquidation preferences, sinking fund terms and the number
of shares constituting, or the designation of, such series, any or all of which may be greater than the rights of common stock.
The issuance of our preferred stock could adversely affect the voting power of holders of common stock and the likelihood that such
holders will receive dividend payments and payments upon our liquidation. In addition, the issuance of preferred stock could have the
effect of delaying, deferring or preventing a change in control of our company or other corporate action. No shares of preferred stock are
outstanding, and we have no present plan to issue any shares of preferred stock.

Anti-Takeover Effects of Provisions of our Amended and Restated Certificate of Incorporation, our Amended and Restated
Bylaws and Delaware Law

Some provisions of Delaware law and our amended and restated certificate of incorporation and our amended and restated bylaws could
make the following transactions more difficult: acquisition of us by means of a tender offer; acquisition of us by means of a proxy contest
or otherwise; or removal of our incumbent officers and directors. It is possible that these provisions could make it more difficult to
accomplish or could deter transactions that stockholders may otherwise consider to be in their best interest or in our best interests,
including transactions that might result in a premium over the market price for our shares.

These provisions, summarized below, are expected to discourage coercive takeover practices and inadequate takeover bids. These
provisions are also designed to encourage persons seeking to acquire control of us to first negotiate with our board of directors. We
believe that the benefits of increased protection of our potential ability to negotiate with the proponent of an unfriendly or unsolicited
proposal to acquire or restructure us outweigh the disadvantages of discouraging these proposals because negotiation of these proposals
could result in an improvement of their terms.

Delaware Anti-Takeover Statute

We are subject to Section 203 of the Delaware General Corporation Law, which prohibits persons deemed “interested stockholders” from
engaging in a “business combination” with a publicly-held Delaware corporation for three years following the date these persons become
interested stockholders unless the business combination is, or the transaction in which the person became an interested stockholder was,
approved in a prescribed manner or another prescribed exception applies. Generally, an “interested stockholder” is a person who, together
with affiliates and associates, owns, or within three years prior to the determination of interested stockholder status did own, 15% or more
of a corporation’s voting stock. Generally, a “business combination” includes a merger, asset or stock sale, or other transaction resulting in
a financial benefit to the interested stockholder. The existence of this provision may have an anti- takeover effect with respect to
transactions not approved in advance by the board of directors, such as discouraging takeover attempts that might result in a premium over
the market price of our common stock.

Undesignated Preferred Stock

The ability to authorize undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting or
other rights or preferences that could impede the success of any attempt to change control of us. These and other provisions may have the
effect of deterring hostile takeovers or delaying changes in control or management of our company.

Special Stockholder Meetings

Our amended and restated bylaws provide that a special meeting of stockholders may be called only by our chairman of the board of
directors, Chief Executive Officer or President, or by a resolution adopted by a majority of our board of directors.

Requirements for Advance Notification of Stockholder Nominations and Proposals

Our amended and restated bylaws establish advance notice procedures with respect to stockholder proposals and the nomination of
candidates for election as directors, other than nominations made by or at the direction of the board of directors or a committee of the
board of directors.

Elimination of Stockholder Action by Written Consent

Our amended and restated certificate of incorporation eliminates the right of stockholders to act by written consent without a meeting.

Classified Board; Election and Removal of Directors; Filling Vacancies

Our board of directors is divided into three classes. The directors in each class will serve for a three-year term, one class being elected
each year by our stockholders, with staggered three-year terms. Only one class of directors will be elected at each annual meeting of our
stockholders, with the other classes continuing for the remainder of their respective three-year terms. Because our stockholders do not
have cumulative voting rights, our stockholders holding a majority of the shares of common stock outstanding will be able to elect all of
our directors. Our amended and restated certificate of incorporation provides for the removal of any of our directors only for cause and
requires at least a 66 2/3% stockholder vote. Furthermore, any vacancy on our board of directors, however occurring, including a
vacancy resulting from an increase in the size of our board, may only be filled by a resolution of the board of directors unless the board
of directors determines that such vacancies shall be filled by the stockholders. This system of electing and removing directors and filling
vacancies may tend to discourage a third party from making a tender offer or otherwise attempting to obtain control of us, because it
generally makes it more difficult for stockholders to replace a majority of the directors.

Choice of Forum

Our amended and restated certificate of incorporation provides that the Court of Chancery of the State of Delaware will be the exclusive
forum for any derivative action or proceeding brought on our behalf; any action asserting a breach of fiduciary duty, or other wrongdoing
by, any of our directors, officers, employees or stockholders; any action asserting a claim against us or any of our directors, officers or
employees arising pursuant to the Delaware General Corporation Law, our amended and restated certificate of incorporation or our
amended and restated bylaws; any action to interpret, apply, enforce or determine the validity of our amended and restated certificate of
incorporation or our amended and restated bylaws; or any action asserting a claim against us or any of our directors, officers or
employees that is governed by the internal affairs doctrine. Although our amended and restated certificate of incorporation contains the
choice of forum provision described above, it is possible that a court could find that such a provision is inapplicable for a particular claim
or action or that such provision is unenforceable.

Amendment of Charter Provisions

The amendment of any of the above provisions, except for the provision making it possible for our board of directors to issue preferred
stock, would require approval by holders of at least 66 2/3% of the voting power of our then outstanding voting stock.

The provisions of the Delaware General Corporation Law, our amended and restated certificate of incorporation and our amended and
restated bylaws could have the effect of discouraging others from attempting hostile takeovers and, as a consequence, they may also inhibit
temporary fluctuations in the market price of our Common Stock that often result from actual or rumored hostile takeover attempts. These
provisions may also have the effect of preventing changes in our management. It is possible that these provisions could make it more
difficult to accomplish transactions that stockholders may otherwise deem to be in their best interests.

Limitations of Liability and Indemnification Matters

Our amended and restated certificate of incorporation contains provisions that limit the liability of our directors for monetary damages
for breach of fiduciary duty as a director to the fullest extent permitted by Delaware law. Consequently, our directors will not be
personally liable to us or our stockholders for monetary damages for any breach of fiduciary duties as directors, except liability for:

•

•

•

•

any breach of the director’s duty of loyalty to us or our stockholders;

any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in Section 174 of the Delaware
General Corporation Law; or

any transaction from which the director derived an improper personal benefit.

Our amended and restated certificate of incorporation and amended and restated bylaws provide that we are required to indemnify our
directors and officers, in each case to the fullest extent permitted by Delaware law. Our amended and restated bylaws also provide that we
are obligated to advance expenses incurred by a director or officer in advance of the final disposition of any action or proceeding, and
permit us to secure insurance on behalf of any officer, director, employee or other agent for any liability arising out of his or her actions in
that capacity regardless of whether we would otherwise be permitted to indemnify him or her under Delaware law. We have entered and
expect to continue to enter into agreements to indemnify our directors, executive officers and other employees as determined by our board
of directors. With specified exceptions, these agreements provide for indemnification for related expenses including, among other things,
attorneys’ fees, judgments, fines and settlement amounts incurred by any of these individuals in any action or proceeding. We believe that
these bylaw provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers. We
also maintain directors’ and officers’ liability insurance.

The limitation of liability and indemnification provisions in our amended and restated certificate of incorporation and amended and restated
bylaws may discourage stockholders from bringing a lawsuit against our directors and officers for breach of their fiduciary duty. They may
also reduce the likelihood of derivative litigation against our directors and officers, even though an action, if successful, might

benefit us and our stockholders. Further, a stockholder’s investment may be adversely affected to the extent that we pay the costs of
settlement and damage.

The NASDAQ Global Market Listing

Our common stock is listed on The Nasdaq Global Market under the symbol “ARDX.”

Transfer Agent and Registrar

The transfer agent and registrar for our common stock is American Stock Transfer & Trust Company, LLC. The transfer agent and registrar’s
address is 6201 15th Avenue, Brooklyn, New York 11219.

LEASE

Exhibit 10.31

THIS INSTRUMENT IS A LEASE (including all exhibits, the “Lease”), dated as of
December  30,  2020  by  and  between  Prospect  Fifth  Ave,  LLC,  a  Massachusetts  limited  liability
company, as (“Landlord”), and Ardelyx, Inc. a Delaware corporation, as (“Tenant”), which relates to
space in the building known as 400 Fifth Avenue (the “Building”) located in Waltham, Massachusetts.
The parties to this instrument (the “Parties”) hereby agree with each other as follows:

ARTICLE I
BASIC LEASE PROVISIONS

1.1

1.2

INTRODUCTION.  The  following  terms  and  provisions  set  forth  basic  data  and,  where
appropriate, constitute definitions of the terms hereinafter listed:

BASIC DATA.
Landlord:

Prospect Fifth Ave, LLC, a Massachusetts limited liability company

Landlord’s Original Address:

465 Waverley Oaks Rd, Suite 500
Waltham, MA 02452

Tenant:

Ardelyx, Inc.

Tenant’s Original Address:

34175 Ardenwood Blvd.
Fremont, CA 94555

per r.s.f
$27.75
$28.44
$29.15
$29.88
$30.63
$31.40

Basic Rent:
Monthly Period
1* – 12
13 – 24
25 – 36
37 – 48
49 – 60
61– 63
* Notwithstanding the Basic Rent set forth above, so long as this Lease is in full force and effect and
Tenant is not in Default under any of the terms and conditions of this Lease, Tenant shall be entitled to
an abatement of the monthly installment of Basic Rent for the first three (3) months (not to exceed 91
days) of the Term of the Lease (“Free Rent Period”). Tenant shall be responsible for the payment of
any separately metered utilities and all other applicable charges under the Lease during the Free Rent
Period, as and to the extent provided in this Lease.

Monthly Payment
$29,748.00
$30,487.68
$31,248.80
$32,031.36
$32,835.36
$33,660.80

Additional Free Rent: Tenant has requested finishes and materials for certain components of the
Landlord’s Work that are in excess of the Building Standard. In the event Tenant had not requested
such upgrades, the Building Standard cost for such portion of the Landlord’s Work would have been
approximately $43,000.00. Landlord shall provide this amount as a credit to Tenant (“Upgrade
Credit”). The Upgrade Credit shall be used first to cover the cost and expense of any separate work
order(s) requested by Tenant of Landlord, and approved in writing (email being sufficient) by
Tenant, during the Landlord’s Work period, thereafter any remaining portion or all of the Upgrade
Credit shall be applied to extend the Free Rent Period on a per diem basis until the Upgrade Credit
has been exhausted. The upgraded finishes and materials shall be performed by Creative Office
Pavilion (“Creative”) for the installation of a DIRRT glass offices and partition system (as
highlighted in yellow and marked with the letter x on the Plan attached hereto labeled “Glass and
Furniture Plan”, included in Exhibit A), and related appurtenances including but not limited to the
installation of all Tenant required lock hardware on the doors. Landlord has reviewed and approved
the general scope of work provided by Creative dated December 22, 2020, but all finals plans for
work to be performed by Creative shall be subject to the prior review and approval of the Landlord.
Tenant shall be responsible for all costs, fees, and expenses associated with the work performed by
Creative, which shall be paid directly by Tenant to Creative in a timely fashion. In the event
Creative’s work or lead time for its materials causes delays to the performance of the Landlord’s
Work, it shall be considered a Tenant Delay extending the Commencement Date on a day for day
basis until Landlord can resume its work and/or deliver the Premises.

Commencement Date: The “Commencement Date” shall be the date upon which the Substantial
Completion (as defined below) of the Landlord’s Work, as described in Exhibit B attached hereto is
Achieved and Landlord delivers full possession of the Premises to Tenant, otherwise in the condition
required by this Lease. Subject to Tenant Delays and the occurrence of the Force Majeure Event
outlined below, the targeted Commencement Date is ninety (90) days after the Effective Date.

Notwithstanding the timeframes listed above, the Parties acknowledge that a Force Majeure Event has
occurred that may delay the Substantial Completion Date. The Force Majeure Event that has occurred
includes but is not limited to: (i) the declaration of a state of emergency by the Governor of Massachusetts
on March 10, 2020; (ii) Order of the Massachusetts Governor Assuring Continued Operation of Essential
Services in the Commonwealth, Closing Certain Workplaces and Prohibiting Gatherings of More than
10 People dated March 23, 2020, March 31, 2020, and April 28, 2020, as may be further amended or
extended, (iii) the City of Waltham’s Building Department closure to the public on March 18, 2020,
possibly delaying and/or preventing the LESSOR from submitting a building permit  application,  and
thereafter delays in scheduling and conducting necessary inspections, (iv) a high likelihood that there
may be a shortage of or inability to obtain labor, materials, or equipment, and (v) the possibility that a
further order, regulation, rule, or law may be promulgated by an applicable governmental entity that may
prohibit the Landlord from commencing or continuing with the Landlord’s Work. This paragraph shall
serve as formal written notice of the occurrence of a Force Majeure Event, and all future correspondence
regarding this matter shall be sent via email.

Rent Commencement Date: Three (3) months (not to exceed 91 days) after the Commencement
Date.

Premises Rentable Area: 12,864 rentable square feet. Said rentable area is agreed to by the parties
and is not subject to further measurement or computation.

Permitted Use: General office use and uses accessory thereto, as permitted by governing law, only.

Escalation Factor: 11.34%, as computed in accordance with the Escalation Factor Computation.

Initial Term: The period beginning as of the Commencement Date and expiring at 11:59 p.m. on the
last  day  of  the  sixty-third  (63rd)  full  calendar  month 
thereafter  (the  “Expiration  Date”).
Notwithstanding the foregoing, if the Commencement Date falls on a day other than the first day of a
calendar  month,  the  Initial  Term  of  the  Lease  will  be  measured  from  the  first  day  of  the  next  full
calendar month following in which the Commencement Date occurs, and the Expiration Date shall be
the last day of the 63rd month thereafter.

First Month’s Rent: $29,748.00, to be deposited with Landlord at Lease Execution.

Security  Deposit:  $62,497.60,  to  be  deposited  with  Landlord  at  Lease  Execution  and  held  as
described in Section 14.17, which may be in cash or in the form of a letter of credit.

Base Operating Expenses/Year: 2021/calendar year

Base Taxes/Year: 2021/calendar year

1.3

ADDITIONAL DEFINITIONS

Anticipated Delivery Date: Ninety (90) days after the Effective Date.

Manager:

Prospect Fifth Ave, LLC

Building  Rentable  Area:  113,399  rentable  square  feet,  which  is  not  subject  to  reduction  on  a
remeasurement by more than one (1%) percent.

Business  Days:  All  days  except  Saturday,  Sunday,  New  Year’s  Day,  Martin  Luther  King  Day,
President’s  Day,  Patriots  Day,  Memorial  Day,  Independence  Day,  Labor  Day,  Columbus  Day,
Veteran’s Day, Thanksgiving Day, Christmas Day (and the following day when any such day occurs on
Sunday.)

Effective Date: The Date this Lease is signed by Landlord and returned by Tenant with all required
deposits  made  in  good  and  sufficient  funds  and  the  Parties  have  mutually  agreed  to  a  final  Plan,
Exhibit A, and Landlord’s Work, Exhibit B.

Default:  As defined in Section 13.1.

Escalation Charges:  The amounts prescribed in Article VIII and Article IX.

Escalation Factor Computation: Premises Rentable Area divided by Building’s Rentable Area.
Force Majeure:  Collectively and individually, strike or other labor trouble, fire or other casualty,
governmental preemption of priorities or other controls in connection with a national or other public
emergency or shortages of, or inability to obtain, fuel, supplies or labor resulting therefrom, or any
other cause, whether similar or dissimilar, beyond a Landlord’s or Tenant’s reasonable control (as
applicable).  Excluded  in  all  events  from  the  foregoing  Force  Majeure  provisions,  is  the  Tenant’s
obligation to pay its rent and other monetary obligations as and when due under the terms of this
Lease.

Tenant’s Liability Insurance: As set forth in Section 10.2.

Land Parcel: The  parcel  of  land  upon  which  the  Building  is  located,  shown  as  Parcel  1  on  a  plan
entitled  “Subdivision  Plan  of  Land,  Prospect  Hill  Executive  Office  Park  Waltham,  Mass.”,  dated
September  19,  1980,  drawn  by  R.E.  Cameron  &  Associates,  Inc.,  recorded  with  Middlesex  South
Registry of Deeds as Plan No. 38 of 1981 and rights appurtenant thereto.

Lease Year or lease year:  Each consecutive twelve (12) calendar month period commencing on  the
Commencement  Date  and  each  anniversary  thereof.  Notwithstanding  the  preceding  sentence,  if  the
Commencement Date shall not be the first day of a calendar month, the second and subsequent lease
years  shall  commence  on  the  first  day  of  the  calendar  month  following  the  first  anniversary  of  the
Commencement Date and each anniversary thereof.

Operating Expenses:  As set forth in Article IX.

Operating Year:  As defined in Section 9.1.

Premises: The  portion  of  the  2nd  (Suite  210)  and  3rd  (Suite  300)  Floors  of  the  Building  shown  on
Exhibit A annexed hereto.

Property:  The Building and the Land Parcel.

Tax Year:  As defined in Section 8.1

Taxes:  As determined in accordance with Section 8.1.

Tenant’s Removable Property:  As defined in Section 5.2.

Term  of  this  Lease: The  Initial  Term  and  any  extension  thereof  in  accordance  with  the  provisions
hereof.

Exhibits: The following Exhibits are annexed to this Lease and incorporated herein by this reference: Exhibit
A – Plan showing Premises

Exhibit B - Landlord’s Work Exhibit
Exhibit B-1 – Building Standards
Exhibit C – Building Services Exhibit
D – Operating Expenses Exhibit E –
Rules and Regulations
Exhibit F – Sample Commencement Date Agreement
Exhibit G – Appraisal Methodology for Extension Option Basic Rent
Exhibit H – Form Letter of Credit

ARTICLE II
PREMISES AND APPURTENANT RIGHTS

2.1

2.2

LEASE OF PREMISES.  Landlord hereby demises and leases to Tenant for the Term of this
Lease and upon the terms and conditions hereinafter set forth, and Tenant hereby accepts from
Landlord, the Premises. Subject to the terms of this Lease, Tenant shall have access to and use
of the Premises for the Permitted Use twenty-four (24) hours per day, seven (7) days per week,
and three hundred sixty-five (365) days per year, subject to the terms of this Lease.

APPURTENANT RIGHTS AND RESERVATIONS. (a) Tenant shall have, as appurtenant to
the  Premises,  the  non-exclusive  right  to  use,  and  permit  its  invitees  to  use  in  common  with
others,  the  parking  areas  and  walkways  on  the  Land  Parcel,  public  or  common  lobbies,
hallways, stairways and elevators and common walkways necessary for access to the Building,
and if the portion of the Premises on any floor includes less than the entire floor, the common
toilets, corridors and elevator lobby of such floor. Tenant shall have the right to use up to 3.4
parking spaces per  1,000  rentable  square  feet  contained  in  the  Premises,  or  thirty four  (34)
parking spaces, provided that Tenant hereby acknowledges that such parking shall be available
on a first come, first serve basis and such spaces shall not be "reserved" for Tenant's exclusive
use.  Tenant  acknowledges  that  Landlord  may  from  time  to  time  designate certain  parking
spaces on the Land Parcel as reserved for "visitors" of all tenants of the Building. Tenant shall
additionally have the right through out the term (as the same may be extended),  in  common
with  other  tenants  of  the  Building,  to  use  the  Cafeteria  and  Fitness  Center,  as  defined  in
Exhibit C.

Tenant  shall  have  no  other  appurtenant  rights  other  than  those  specifically  set  forth  in  this
Section 2.2(a) and all such rights shall always be subject to reasonable rules and regulations
from  time  to  time  established  by  Landlord  pursuant  to  Section  14.7  and  to  the  right  of
Landlord  to  designate  and  change  from  time  to  time  areas  and  facilities  so  to  be  used.
Notwithstanding the foregoing, Landlord shall not materially impede or obstruct access to and
from the Premises or the availability of proximate parking in the manner provided as of the
Effective Date.

(b)  Excepted  and  excluded  from  the  Premises  are  the  ceiling,  floor,  perimeter  walls  and
exterior  windows,  except  the  inner  surfaces  thereof  and  any  space  or  areas  in  the  Premises
used  for  shafts,  pipes,  stacks,  conduits,  fan  rooms  ducts,  electricity  or  other  utilities,
mechanical rooms or other Building facilities, but the entry doors (and related glass and finish
work) to the Premises are a part thereof. Tenant agrees that Landlord shall have the right to
place  in  the  Premises  interior  storm  windows,  subcontrol  devices  (by  way  of  illustration,  an
electric  sub  panel,  etc.),  utility  lines,  pipes,  equipment  and  the  like,  in,  over  and  upon  the
Premises.

3.1

PAYMENT. (a) Tenant agrees to pay to Landlord, or as directed by Landlord, commencing on
the Commencement Date (but subject to abatement, delay or credit as expressly provided by
this  Lease),  the  Basic  Rent  and,  if  and  when  due  and  payable,  Escalation  Charges.  Such
Basic  Rent  and  Escalation  Charges  shall  be  payable  in  equal  monthly  installments,  in
advance, on the first day of each and every calendar month during the Term of this Lease in
lawful  money  of  the  United  States.  Until  notice  of  some  other  designation  is  given,  Basic
Rent and Escalation Charges, and all other charges for which provision is herein made  shall
be paid by remittance payable to Landlord and addressed to 465 Waverley Oaks Road, Suite
500,  Waltham,  MA  02452  and  all  remittances  so  received  as  aforesaid,  or  by  any
subsequently designated recipient, shall be treated as a payment to Landlord. In the event that
monthly installment of Basic Rent or the Escalation Charges, if applicable, is not paid within
two  (2)  Business  Days  of  when  due,  Tenant  shall  pay,  in  addition  to  any  other  additional
charges due under this Lease, an administrative fee equal to five percent (5%) of the overdue
payment.

(b) Basic Rent for any partial month shall be pro-rated on a daily basis, and if the first day on
which Tenant must pay Basic Rent shall be other than the first day of a calendar month, the
first payment which Tenant shall make to Landlord shall be equal to a proportionate part of the
monthly installment of Basic Rent for the partial month from the first day on which  Tenant
must  pay  Basic  Rent  to  the  last  day  of  the  month  in  which  such  day  occurs,  plus  the
installment of Basic Rent for the succeeding calendar month.

3.2

(a) This Lease is a gross lease, and the Basic Rent includes rent on the

GROSS LEASE.
Premises plus the Tenant’s pro rata share of Operating Expenses and Taxes. Basic Rent and
Escalation Charges payable by Tenant hereunder shall be paid without notice or demand, and
without setoff, counterclaim, defense, abatement, suspension, deferment, reduction or
deduction, except as expressly provided by this Lease.

(b) This Lease shall not terminate, nor shall Tenant have any right to terminate this lease, nor
shall the obligations and liabilities of Tenant set forth herein be otherwise affected, except as
expressly provided by this Lease.

(c) Tenant  waives  all  rights  (i)  to  any  abatement,  suspension,  deferment,  reduction  or
deduction of or from the Basic Rent or other charges payable by Tenant hereunder or (ii) to
quit, terminate or surrender this Lease or the Premises or any part thereof, except as expressly
provided herein.

(d) It  is  the  intention  of  the  parties  hereto  that  the  obligations  of  Tenant  hereunder  shall  be
separate  and  independent  covenants  and  agreements,  that  the  Basic  Rent  or  other  charges
payable by Tenant hereunder shall continue to be payable in all events and that the obligations of
Tenant hereunder shall continue unaffected, unless the requirement to pay or perform the same
shall have been terminated, suspended or abated pursuant to an express provision of this Lease.

4.1

4.2

4.3

ARTICLE IV
COMMENCEMENT AND CONDITION

COMMENCEMENT DATE. The Commencement Date shall be the date specified in Section
1.2.  Notwithstanding the foregoing, if Tenant’s personnel shall occupy all or  any  part of  the
Premises for the material conduct of its business prior to the Commencement Date, such date
shall  for  all  purposes  of  this  Lease  be  the  Commencement  Date.  The  Tenant  shall,  upon
demand of the Landlord, execute with Landlord a certificate confirming the Commencement
Date as it is determined in accordance with the provisions of this Section 4.1 and similar to the
form  Commencement  Date  Agreement  attached  hereto  as  Exhibit  F.  Notwithstanding  the
foregoing,  Tenant’s  early  access  to  the  Premises  for  installation  of  wiring,  cabling,  and
otherwise shall in no event constitute Tenant’s conduct of its business hereunder.

PREMISES TO BE DELIVERED “AS IS”. Landlord shall deliver to Tenant on or about
the  Anticipated  Delivery  Date  full  possession  of  the  Premises  (free  and  clear  or  all  rights,
claims,  and  possessions  of  Landlord  and  others)  and  with  all  of  the  Landlord’s  Work
Substantially  Completed  and  ready  for  Tenant’s  immediate  occupancy  and  use  for  the
Permitted Use. Except as provided in the preceding sentence and subject to the Substantial
Completion of the Landlord’s Work (hereinafter defined), the Premises are to be delivered by
Landlord "as is," in their present condition, and Landlord shall not be required to perform any
work to the Premises or the Building prior to the Commencement Date. Tenant acknowledges
that  it  has  inspected  the  Premises,  and  that  it  is  not  relying  on  any  representations  and
warranties by Landlord or any agreements by Landlord  not expressly set forth  in  this  Lease.
Notwithstanding  the  foregoing,  Landlord  represents  to  Tenant  and  covenants  that  all
mechanical and operating systems, electrical systems and equipment and plumbing  systems
shall as of the Commencement Date be in good working order.

LANDLORD’S WORK. Landlord  shall  cause,  at  Landlord’s  sole  cost  and  expense,  to  be
performed the work required by Exhibit B (“Landlord’s Work”) to be substantially complete on
or  about  the  Anticipated  Delivery  Date.  All  such  work  shall  be  done  in  a  good  and
workmanlike  manner  employing  building  standard  methods  using  contractors  licensed  in
Massachusetts, for the trade required, and shall comply with all laws, regulations, orders, and
authorizations  applicable  thereto.  Landlord  shall  be  obligated  to  obtain  at  Landlord’s  sole
cost and expense all permits necessary for Landlord’s Work and a certificate of occupancy as
of or soon after Substantial Completion, thereof. Tenant agrees that Landlord may make any
immaterial  changes  in  such  work  which  may  become  reasonably  necessary  or  advisable,
without approval of Tenant; and Landlord may make material changes in such work but only
with  the  prior  approval  of  Tenant  or  it  is  required  by  any  applicable  change  in law  or
regulation.  Tenant  agrees  to  review  and  approve  or  disapprove  plans  or  specifications or
proposed changes to Landlord Work for which Tenant's approval is required within five
(5) days of submittal to Tenant. If Tenant does not so respond, such plans or specifications
shall be deemed approved. The term “Substantially Complete” or “Substantial Completion,” as
used herein, shall mean: (i) that Landlord’s Work to be performed pursuant to Exhibit B has
been completed, with the exception of minor punch list items which can be fully completed
within  sixty  (60)  days  of  Substantial  Completion  and  without  material  interference  with
Tenant’s use and occupancy for the Permitted Use, and other items which

4.4

because of season or weather or the nature of the item are not practicable to do at the time,
provided  that  none  of  said  items  are  necessary  to  make  the  Premises  tenantable  for  the
Permitted  Use  by  Tenant;  and  (ii)  Landlord  has  obtained  all  approvals  necessary  for  the
issuance  of  a  Certificate  of  Occupancy  from  the  City  of  Waltham  for  the  Premises  as
improved by the Landlord’s Work, with such certificate issuing in due course of the City’s
normal  course  of  business.  Landlord  shall  retain  the  risk  in  the  event  the  City  of  Waltham
delays or fails to issue a permanent Certificate of Occupancy. Landlord shall indemnify and
hold  Tenant  harmless  for  any  related  claims  for  any  such  delay  or  non-issuance  of  the
Certificate  of  Occupancy.  Subject  to  the  foregoing,  Tenant’s  use  of  the  Premises  for  the
Permitted  Use  and  material  operation  of  its  business  within  the  Premises  shall  be  deemed
conclusive evidence of Substantial Completion of Landlord’s Work.

DELAYS.  Subject  to  the  occurrence  of  a  Force  Majeure  Event,  any  changes  to  the  Force
Majeure  Event  references  in  Section  1.2,  and  Tenant  Delays,  if  Landlord  fails  to
Substantially Complete the Landlord’s work and deliver to Tenant possession of the Premises
in  the  condition  required  by  this  Lease:  (i)  as  of  ninety  (90)  days  after  the  Anticipated
Delivery Date, Tenant shall receive a credit equal to one (1) day’s free Basic Rent for  each
day  from  and  after  the  sixty  first  (61st)  day  after  the  Anticipated  Date  until  the actual
Commencement Date and possession of the Premises is delivered to Tenant in the condition
required by this Lease, with all of the Landlord’s Work Substantially Complete;
(ii) as of one hundred and twenty (120) days after the Anticipated Delivery Date, Tenant shall
receive a credit equal to two (2) day’s free Basic Rent for each day from and after the ninety
first (91st) day after the Anticipated Delivery Date until the actual Commencement Date and
possession of the Premises is delivered to Tenant in the condition required by this Lease, with
all of the Landlord’s Work Substantially Complete; and (iii) as of one hundred eighty  (180)
days after the Anticipated Delivery Date (without regard to the occurrence of Force Majeure
Event, but subject to extension for Tenant Delays), Tenant shall thereafter have  the  right  to
Terminate  this  Lease  with  thirty  (30)  days’  written  notice,  in  which  event  Landlord  shall
promptly refund to Tenant all prepaid rent and the Security Deposit (except as provided for
below) and this Lease shall terminate and be of no further force or effect. Provided however,
in the event Landlord can deliver the Premises within the foregoing thirty
(30)  days  Tenant’s  right  to  terminate  shall  be  null  and  void.  Any  credit  of  free  Basic  rent
hereunder shall be applied to Basic rent due and payment immediately after expiration of the
Free Rent Period. Provided if the Landlord’s failure to Substantially Complete the Landlord’s
Work and deliver the Premises is solely due to the occurrence of a Force Majeure Event  or  a
change in circumstances in the present Force Majeure Event described above  and not  due  to
the delay or negligence of the Landlord, and the Lease is ultimately terminated, Tenant shall
be responsible for half of the costs, expenses, and fees incurred by Landlord in performance
of  the  Landlord’s  Work  in  accordance  with  the  agreed  upon  budget  for Landlord’s  Work,
through  the  actual  termination  date  (“Landlord’s  Work  Reimbursement”). The  Landlord’s
Work  Reimbursement  shall  be  billed  to  Tenant  after  the  actual  termination  date  and  due
within  thirty  (30)  days  of  Tenant’s  receipt  of  such  billing.  Landlord  may  elect to  apply  the
Tenant’s prepaid rent and Security Deposit against the Landlord’s Work Reimbursement.

ARTICLE V USE

OF PREMISES

5.1

PERMITTED USE.  (a) Tenant agrees that the Premises shall be used and occupied by
Tenant and Tenant’s employees only for the Permitted Use and for no other purpose.

(b) Tenant agrees to conform to the following provisions during the Term of this Lease:

(i) Tenant  shall  cause  all  freight  to  be  delivered  to  or  removed  from  the  Building  and  the
Premises  in  accordance  with  reasonable  rules  and  regulations  established  by  Landlord
therefor;

(ii) Tenant shall not place or permit to be placed or maintained on any doors, exterior walls,
windows  (including  both  interior  and  exterior  surfaces  of  windows  and  doors)  of  the
Premises  any  sign  (free  standing  or  otherwise),  awning  or  canopy  (if  applicable),  or
advertising matter or other thing of any kind, and shall not place or maintain any decoration,
lettering, sign, or advertising matter on the glass of any window or door of the Premises or
anywhere in the interior of the Premises visible from the exterior or from the common areas
thereof  without  first  obtaining  Landlord’s  prior  written  consent.  Tenant  further  agrees  to
maintain such signs, awnings or canopies (if applicable), decorations, lettering, advertising
matter  or  other  things  as  may  be  installed  by  Tenant  and  approved  by  Landlord  in  good
condition, operating order, and repair at all times. All approved signs of Tenant visible from
the  common  areas  of  the  Building  shall  be  in  good  taste,  professionally  lettered,  and  shall
conform  to  the  standards  of  design,  motif,  and  décor  from  time  to  time  established  by
Landlord  for  the  Building.  No  flashing  signs  shall  be  permitted.  No  credit  card  signs,
advertisements,  free-standing  signs  nor  any  hand  lettered  signs  shall  be  visible  from  the
common areas. Tenant shall install professionally lettered signs on its service/second door, if
applicable. Tenant will not place on the exterior of the Premises (including both interior and
exterior surfaces of doors and interior surfaces of windows) or on any part of the Building
outside the Premises, any signs (free-standing or otherwise), symbol, advertisements or the
like  visible  to  public  view  outside  of  the  Premises.  Landlord  shall  provide  Tenant  with
building  standard  identity  signage  (i)  on  the  main  building  lobby  directory  at  Landlord’s
expense, and (ii) on the main entry to the Premises, at Tenant’s expense, (either on the door
or  on  the  wall  immediately  adjacent  to  the  main  entry  to  the  Premises,  consistent  with
building standard practices);

(iii) Tenant shall not perform any act or carry on any practice which injure the Premises, or
any other part of the Building, or cause offensive odors or loud noise or constitute a nuisance or
menace to any other tenant or tenants or other persons in the Building;

(iv) Tenant shall, in its use of the Premises, comply with the requirements of all applicable
governmental laws, rules and regulations including, without limitation, the Americans With
Disabilities  Act  of  1990,  as  amended  and  any  regulations  promulgated  thereunder  to  the
extent applicable to the Premises; and

(v) Tenant shall throughout the Term of this Lease occupy the Premises for the Permitted

5.2

Use and for no other purposes.

INSTALLATION  AND  ALTERATIONS  BY  TENANT.  (a)  Tenant  shall  make  no
alterations,  additions  (including,  for  the  purposes  hereof,  wall-to-wall  carpeting),  or
improvements  in  or  to  the  Premises  without  Landlord's  prior  written  consent.  Any  such
alterations,  additions  or  improvements  shall  (i)  be  in  accordance  with  complete  plans  and
specifications  prepared  by  Tenant  where  appropriate  given  the  nature  of  the  alterations,
additions,  and  improvements  and  approved  in  advance  by  Landlord;  (ii)  be  performed  in  a
good and workmanlike manner and in compliance with all applicable laws including, without
limitation,  The  Americans  with  Disabilities  Act  of  1990,  as  amended  and  any  regulations
promulgated thereunder; (iii) be performed and completed in the manner required in Section
5.2(d) hereof; (iv) be made at Tenant's sole expense and at such times as Landlord may  from
time to time designate; and (v) become a part of the Premises and the property of Landlord
(and Tenant shall have no obligation to remove such alterations, additions, or improvements
made  by  or  on  behalf  of  Tenant  or  to  restore  the  Premises,  unless  otherwise  directed  by
Landlord  in  the  applicable  written  consent  instrument).  Notwithstanding  the  foregoing,
Tenant may make alterations, additions, and improvements having a total cumulative cost of
less  than  $25,000.00  annually  during  the  term  of  the  Lease  and  that  do  no involve  the
structural  portions  of  the  Building  or  common  mechanical  or  operating  systems without
Landlord’s approval, but with prior written notice.

(b) All articles of personal property and all machinery, equipment, removable fixtures, and
furniture owned or installed by Tenant in the Premises ("Tenant's Removable Property") shall
remain  the  property  of  Tenant  and  may  be  removed  by  Tenant  at  any  time  prior  to  the
expiration of this Lease, provided that Tenant, at its expense, shall repair any damage to the
Building caused by such removal.

(c) Notice  is  hereby  given  that  Landlord  shall  not  be  liable  for  any  labor  or  materials
furnished or to be furnished to Tenant upon credit, and that no mechanic’s or other lien for
any such labor or materials shall attach to or affect the reversion or other estate or interest of
Landlord  in  and  to  the  Premises.  Whenever  and  as  often  as  any  mechanic's  lien  shall  have
been filed against the Premises based upon any act or interest of Tenant or of anyone claiming
through Tenant, Tenant shall forthwith take such actions by bonding, deposit or payment as
will remove or satisfy the lien.

(d) All  of  the  Tenant's  alterations,  additions  and  installation  of  furnishings  shall  be
reasonably coordinated with any work being performed by Landlord and in such manner as
to  maintain  harmonious  labor  relations  (but  without  obligation  for  Tenant  to  use  unionized
labor) and not damage the Property or interfere with Building construction or operation  and,
except  for  installation  of  furnishings,  shall  be  performed  by  contractors  or  workmen  first
approved by Landlord. Installation and moving of furnishings, equipment and the like shall
be performed only with labor not reasonably objectionable to Landlord for work in or to the
Building. Except for work by Landlord's general contractor, Tenant, before its work is started
shall: secure all licenses and permits necessary therefor; deliver to Landlord a statement  of
the names of all its contractors and subcontractors and the estimated cost of all

labor  and  material  to  be  furnished  by  each  of  them;  and  cause  each  contractor  to  carry
workmen's  compensation  insurance  in  statutory  amounts  covering  all  the  contractor's  and
subcontractor's  employees  and  commercial  public  liability  insurance  and  property  damage
insurance  with  such  limits  as  Landlord  may  reasonably  require  consistent  with  prevailing
requirements for similar types of work in similar buildings where the Building is located, but in
no  event less  than a  combined single limit of Two  Million  and  No/100ths  ($2,000,000.00)
Dollars (all such insurance to be written in companies reasonably approved by Landlord and
insuring  Landlord  and  Tenant  as  well  as  the  contractors),  and  to  deliver  to  Landlord
certificates of all such insurance. Tenant agrees to pay promptly when due the  entire  cost of
any work done on the Premises by Tenant, its agents, employees, or independent contractors,
and not to cause or permit any liens for labor or materials performed or furnished in correlation
therewith to attach  to  the  Premises  or  the  Property  and  immediately  to  discharge  any  such
liens  which  may  so  attach  and,  at  the  request  of  Landlord  to  deliver  to  Landlord  security
reasonably satisfactory to Landlord against  liens  arising  out  of  the  furnishing of such labor
and material where such lien arise, which is not so discharged. Upon completion of any work
done  on  the  Premises  by  Tenant,  its  agents,  employees,  or  independent contractors,  Tenant
shall  promptly  deliver  to  Landlord  original  lien  releases  and waivers  executed  by  each
contractor,  subcontractor,  supplier,  material  men,  architect,  engineer  or  other  party  which
furnished  substantial  labor,  materials  or  other  services  in  connection  with  such  work  and
pursuant  to  which  all  liens,  claims  and  other  rights  of  such  party  with  respect  to  labor,
material or services furnished in connection with such work are unconditionally released and
waived. Tenant shall pay within fourteen (14) days after being billed therefor by Landlord, as
an  additional  charge  hereunder,  one  hundred  percent  (100%) of  any  increase  in  real  estate
taxes  on  the  Property  not  otherwise  billed  to  Tenant  which  shall,  at  any  time  after
commencement of the Term, directly attributable to any alteration, addition or improvement to
the Premises  made  by  or  on  behalf  of  Tenant  (excluding  Tenant's  original installation  and
Tenant's  subsequent  alterations,  additions,  substitutions  and  improvements) whether  done
prior to or after the commencement of the Term of this Lease. Notwithstanding the foregoing,
Tenant shall have the right, if diligently exercised and prosecuted, to contest any such liens or
claims  without  discharge  or  release  (or  payment)  thereof  if  reserves  or  security reasonably
acceptable to Landlord are established.

ARTICLE VI

ASSIGNMENT AND SUBLETTING

6.1   PROHIBITION. (a) Tenant covenants and agrees that whether voluntarily, involuntarily, by
operation of law or otherwise, neither this Lease nor the term and estate hereby granted, nor
any  interest  herein  or  therein,  will  be  assigned,  mortgaged,  pledged,  encumbered  or
otherwise transferred and that neither the Premises nor any part thereof will be  encumbered in
any manner by reason of any act or omission on the part of Tenant, or used or occupied, by
anyone other than Tenant, or for any use or purpose other than a Permitted Use, or be sublet
(which term, without limitation, shall include granting of concessions, licenses and the like)
in whole or in part, or be offered or advertised for assignment or subletting, without in  each
such case the written consent of Landlord (which consent to any assignment of this Lease  or
sublease of all  of the Premises  shall not be unreasonably withheld, delayed or

conditioned  where  use  of  the  Premises  continues  for  the  Permitted  Use  and  the  assignee,
sublessee  or  transferee  has  a  financial  condition  not  less  than  that  of  Tenant  as  of  the
Effective Date).

(b) The provisions of paragraph (a) of this Section shall apply to a transfer (by one or more
transfers)  of  a  majority  of  the  stock  or  partnership  interests,  or  other  evidences  of
ownership  of  Tenant  as  if  such  transfer  were  an  assignment  of  this  Lease;  but  such
provisions shall not apply to (and the consent or approval of Landlord shall not be required,
but  with notice no later  than  thirty  (30)  days  of  such  transfer)  transactions  with an entity
into  or  with  which  Tenant  is  merged  or  consolidated  or  to  which  substantially  all  of
Tenant's assets are transferred or to any entity which controls or is controlled by Tenant or is
under common control with Tenant (a “Merger/Sale”), provided that in any of such events
(i) the successor to Tenant has a net worth computed in accordance with generally accepted
accounting principles at least equal to the net worth of Tenant at the time of execution and
delivery of  this  Lease  as  evidenced  by the  financial  information  provided  to Landlord  by
Tenant prior to execution and delivery of this Lease, (ii) evidence reasonably satisfactory to
Landlord (financial statements consistent with those provided by the original named  Tenant
hereunder  in  connection  with  Landlord’s  entering  into  this  Lease  being  deemed
satisfactory) of such net worth shall have been delivered to Landlord at least ten
(10) days prior to the  effective  date  of  any  such  transaction,  and  (iii)  the  assignee agrees
directly with Landlord, by written instrument in form reasonably satisfactory to Landlord,
to  be  bound  by  all  the  obligations  of  Tenant  hereunder  including,  without  limitation,  the
covenant  against  further  assignment  or  subletting,  except  as  expressly  permitted  by  this
Lease.  In  addition  to  a  Merger/Sale,  Tenant  may  expressly  assign  this  Lease,  sublease  or
license all or any portion of the Premises or otherwise make a transfer (a Merger/Sale and
each  of  the  following  being  a  "Permitted  Transfer")  without  Landlord’s  consent  or
approval, for transfers of registered ownership interests on a recognized exchange.

(c) If this Lease is assigned, or if the Premises or any part thereof is sublet or occupied by
anyone  other  than  Tenant  other  than  under  a  Permitted  Transfer  (and  in  such  case,  only
after a Default under this Lease), Landlord may, at any time and from time to time, collect
rent and other charges from the assignee, subtenant or occupant, and apply the net amount
collected to the rent and other charges herein reserved, but no such assignment, subletting,
occupancy,  collection  or  modification  of  any  provisions  of  this  Lease  shall  be  deemed  a
waiver  of  the  foregoing  covenant  where  applicable,  or  the  acceptance  of  the  assignee,
subtenant or occupant as a tenant or a release of the original named Tenant from the further
performance  by  the  original  named  Tenant  hereunder.  No  assignment  or  subletting
hereunder shall relieve Tenant from its obligations hereunder and Tenant shall remain fully
and  primarily  liable  therefor.  No  assignment  or  subletting,  or  occupancy  shall  affect
Permitted Use.

(d) If  Tenant  shall  request  Landlord  to  consent  to  an  assignment  of  this  Lease  or  a
subletting  (a  "Request"),  Tenant  shall  submit  to  Landlord  in  writing:  (i)  the  name  of  the
proposed assignee or subtenant, (ii) such information as to its financial responsibility and

standing as Landlord may reasonably require, and (iii) all terms and provisions upon which
the proposed assignment or subletting is to be made.

In any case where such consent is required and Landlord consents to an assignment or
(e)
subletting, Landlord shall be entitled to receive fifty (50%) percent of all rental amounts after
the deduction for all reasonable costs and expenses related to such sublease or assignment
(the "Overages") received by Tenant in excess of Basic Rent, Escalation Charges and other
items of additional rent reserved under this Lease attributable to the space sublet or assigned
including, without limitation, all lump sum rental payments made in connection therewith.
Payments of Overages shall be made by Tenant to Landlord as additional rent  within  five
(5) days of receipt thereof by Tenant.

(d) Landlord shall never be deemed unreasonable in denying its consent to an assignment of
this  Lease  or  a  subletting  of  all  or  any  portion  of  the  Premises  where  such  consent  is
required: (i) in the event that Landlord, in its reasonable judgment, shall determine that the
net  worth  or  financial  capability  of  such  proposed  subtenant  or  assignee  is  insufficient  to
perform  its  financial  obligations  under  this  Lease  as  an  assignee  or  subtenant;  or  (ii)  if  a
subletting,  such  subletting  would  result  in  more  than  two  (2)  subtenants;  or  (iii)  if  such
assignment  or  subletting  would  require  the  Premises  be  used  for  other  than  the  Permitted
Use or require alterations to the Premises inconsistent with the Permitted Use or (iv) if such
assignment or subletting is to an existing tenant or occupant of the Building or a prospective
Tenant who has inquired about space within the last twelve (12) months; or (v) if there is a
vacancy in the Building of space of a similar size and amenity, if the terms and conditions of
the assignment or subletting are less favorable than those conditions on which Landlord is
then offering to lease such vacant space for a comparable term (or, if Landlord is not then
offering  space  in  the  Building  for  lease,  those  terms  and  conditions  which,  in  Landlord's
reasonable  opinion,  Landlord  would  offer  to  lease  space  in  the  Building)  consistent  with
proposals for space within the Building offered within the prior twelve (12) months.

ARTICLE VII
RESPONSIBILITY FOR REPAIRS AND CONDITIONS OF PREMISES
SERVICES TO BE FURNISHED BY LANDLORD

7.1 LANDLORD REPAIRS.  (a) Except as otherwise provided in this Lease, Landlord agrees to
keep and maintain in good working order, condition and repair (and replace as necessary) the
foundation,  roof,  common  areas,  public  areas  (including  loading  dock  areas,  exterior
landscaping  and  parking  areas  on  the  Land  Parcel),  exterior  walls  (including  exterior  glass)
and structure of the Premises and the Building (including weight bearing walls and columns,
plumbing, mechanical, operating and electrical systems, including without limitation, common
heating, ventilation and air  conditioning,  but  excluding  any  systems  installed specifically for
Tenant's  benefit  and  which  exclusively  serve  the  Premises),  all  insofar  as  they affect  the
Premises, except that Landlord shall in no event (other than due to the gross negligence or act
of Landlord, its agents, employees or contractors) be responsible to Tenant for the condition of
glass  in  the  Premises  or  for  the  doors  (or  related  glass  and  finish  work)  leading  to  the
Premises, or for any condition in the Premises or the Building caused by any act or neglect of
Tenant, its agents, employees, invitees or contractors. The fact that Landlord

7.2

is responsible for the foregoing described repairs shall not be construed to prohibit the costs
thereof from being included in Operating Expenses. Landlord shall not be responsible to make
any improvements or repairs to the Building other than as expressly provided in this Section
7.1 or unless expressly provided otherwise in this Lease.

(b) Landlord  shall  never  be  liable  for  any  failure  to  make  repairs  which  Landlord  has
undertaken to make under the provisions of this Section 7.1 or elsewhere in this Lease; unless
Tenant  has  given  notice  to  Landlord  of  the  need  to  make  such  repairs,  and  Landlord  has
failed to commence to make such repairs within a reasonable time after receipt of such notice, or
fails to proceed with reasonable diligence to complete such repairs.

(c) Any  services  which  Landlord  is  required  to  furnish  pursuant  to  the  provisions  of  this
Lease  may,  at  Landlord's  option  be  furnished  from  time  to  time,  in  whole  or  in  part,  by
employees of Landlord or by the Manager of the Property or by one or more third persons.

TENANT’S  AGREEMENT.  (a)  Tenant  will  keep  neat  and  clean  and  maintain  in  good
order, condition and repair the Premises and every part thereof, excepting only those  repairs
for which Landlord is responsible under the terms of this Lease, reasonable wear and tear of
the Premises, and damage by fire or other casualty and as a consequence of the exercise of
the  power  of  eminent  domain,  and  Tenant  shall  surrender  the  Premises,  at  the  end  of  the
Term, in such condition. Without limitation, Tenant shall continually during the Term of this
Lease maintain the Premises in all material respects in accordance with all laws, codes and
ordinances from time to time in effect and all directions, rules and regulations of the proper
officers  of  governmental  agencies  having  jurisdiction,  and  of  the  applicable  Board  of  Fire
Underwriters,  and  shall,  at  Tenant's  own  expense,  obtain  all  permits,  licenses  and  the  like
required  by  applicable  law  from  and  after  the  Commencement  Date  in  connection  with  the
operation of Tenant’s business within the Premises. Notwithstanding the foregoing or any of
the  other  provisions  of  this  Article  VII,  Tenant  shall  be  responsible  for  the  cost  of  repairs
which  is  necessary  by  reason  of  damage  to  the  Property  caused  by  any  act  or  neglect  of
Tenant or its agents, employees, contractors or invitees (including any damage by fire or  any
other casualty arising therefrom).

Without limitation of the foregoing, Tenant shall not do or perform, and shall not permit its
agents,  servants,  employees,  contractors  or  invitees  to  do  or  perform  any  act  or  thing  in  or
upon the Property which will invalidate or be in conflict with the certificate of occupancy for
the  Premises  or  the  Building  or  violate  any  statute,  law,  rule,  by-law  or  ordinance  of  any
governmental entity having jurisdiction over the Property (the "Requirements"). Tenant shall,
at Tenant's sole cost and expenses, take all action, including the making of any improvements
or alterations to the Premises necessary to comply with all Requirements (including, but not
limited to the Americans With Disabilities Act of 1990 (the "ADA") taking effect from  and
after  the  Commencement  Date,  as  modified  and  supplemented  from time  to  time)  which
shall, with respect to the Premises or with respect to any abatement of nuisance, impose any
violation,  order  or  duty  upon  Landlord  or  Tenant  arising  from,  or  in  connection  with  the
Premises,  Tenant's  occupancy,  use  or  manner  of  use  of  the  Premises  (including,  without
limitation,  any  occupancy,  use  or  manner  of  use  that  constitutes  a  "place  of  public
accommodation" under the ADA), or any installations in the Premises made by or

for  the  Tenant  (but  excluding  work  associated  with  the  Landlord’s  Work),  or  required  by
reason of a breach of any of Tenant's covenants or agreements under this Lease, whether or
not such Requirements shall now be in effect or hereafter enacted or issued, and whether or
not any work required shall be ordinary or extraordinary or foreseen or unforeseen at the date
hereof. Notwithstanding the preceding sentence, Tenant shall not be obligated to perform any
alterations necessary to comply with any Requirements, unless compliance shall be required
by reason of (i) any cause or condition arising from and after the Commencement Date out of
any alterations or installations in the  Premises  (whether  made  by  Tenant  or  by Landlord on
behalf  of Tenant  but  excluding  any cause or  condition  arising  out  of  Landlord’s Work),  (ii)
Tenant's particular use, manner of use or occupancy of the Premises (as opposed to mere use
as  executive,  general  and  administrative  offices),  (iii)  any  breach  of  any  of  Tenant's
covenants or agreements under this Lease, or (iv) any wrongful act or omission by Tenant or
Tenant's agents, servants, employees, contractors or invitees, or (v) Tenant's use or manner of
use or occupancy of the Premises as a "place of public accommodation" within the meaning of
the ADA.

(b) If repairs are required to be made by Tenant pursuant to the terms hereof, Landlord may
demand  that  Tenant  make  the  same  forthwith  (but  subject  to  Tenant’s  ability  to  obtain
permits,  labor  and  materials  and  subject  to  occurrence  of  a  Force  Majeure  Event),  and  if
Tenant refuses or neglects to commence such repairs and complete the same with reasonable
dispatch  after  such  demand  (but  subject  to  Tenant’s  ability  to  obtain  permits,  labor  and
materials and subject to the occurrence of Force Majeure Event), Landlord may (but shall not
be required to do so) make or cause such repairs to be made (the provisions of Section
14.18  being  applicable  to  the  reasonable  out  of  pocket  costs  thereof)  and  shall  not  be
responsible to Tenant for any loss or damage that may accrue to Tenant's stock or business by
reason thereof. Notwithstanding the foregoing, Landlord may elect to take  action  hereunder
immediately and without notice to Tenant (but Landlord shall in such event make reasonable
effort to provide Tenant with advance telephonic notice) if Landlord reasonably believes  an
emergency to exist which imminently threatens loss or damage to persons or property.

7.3

FLOOR LOAD – HEAVY MACHINERY. (a) Tenant shall not place a load upon any floor
in  the  Premises  exceeding  the  floor  load  per  square  foot  of  area  which  such  floor  was
designed  to  carry,  and  which  is  allowed  by  law.  Business  machines  and  mechanical
equipment shall be placed and maintained by Tenant at Tenant's expense in settings sufficient,
in Landlord's reasonable judgment, to absorb and prevent vibration, noise and annoyance of a
type or degree which would (i) cause damage to the Premises or the Building or (ii) constitute a
nuisance or annoyance for other tenants of the Building (giving due regard to the commercial
nature of the Building).

(b) If  such  safe,  machinery,  equipment,  freight,  bulky  matter  or  fixtures  requires  special
handling, Tenant agrees to employ only persons holding a Master Rigger's License to do such
work,  and  that  all  work  in  connection  therewith  shall  comply  with  applicable  laws  and
regulations. Any such moving shall be at the sole risk and hazard of Tenant, and Tenant will
exonerate, indemnify and save Landlord harmless against and from any liability, loss, injury,
claim or suit resulting directly or indirectly from such moving, except to the extent arising

7.4

8.1

from the negligence or willful misconduct of Landlord or its employees, contractors, agents or
invitees.

BUILDING SERVICES. Subject to the terms and provisions of Exhibit C, Landlord shall
provide  the  Building  Services  described  in  Exhibit  C.  Tenant  will  pay  to  the  Landlord  a
reasonable  charge  for  any  extra  cleaning  of  the  Premises  required  because  of  the  unusual
generation  of  waste  or  cleaning  needs  due  to  Tenant’s  use  of  the  Premises  above  that
required  for  typical  general  office  usage  but  not  including  general  cleaning  requirements
related to the pending COVID-19 emergency (which  shall  be  Landlord’s  obligation  within
the  common  areas  of  the  Building  and  the  Tenant’s  obligation  within  the  Premises),
additional/augmented  cleaning  within  the  Premises  requested  by  Tenant  and/or  otherwise
required  by  applicable  state  and  local  requirements  but  not  including  general  cleaning
requirements related to the pending COVID-19 emergency, and for any Additional Services
rendered at the request of Tenant. If the cost of cleaning the Premises shall be increased due
to  the  installation  in  the  Premises,  at  Tenant's  request,  of  any  unique  or special  materials,
finish  or  equipment  (after  Tenant’s  having  been  notified  of  the  resulting increased  cost),
Tenant  shall  pay  to  Landlord  an  amount  equal  to  such  increase  in  cost.  All charges  for
additional services due under this Lease shall be due and payable within ten
(10) days of the date on which they are billed.

ARTICLE VIII
REAL ESTATE TAXES

PAYMENTS ON ACCOUNT OF TAXES. (a) For the purposes  of  this  Article,  the  term
"Tax Year" shall mean each calendar year in which any part of the Term of this Lease shall
fall;  and  the  term  "Taxes"  shall  mean  all  taxes  and  assessments  of  every  kind  and  nature
imposed, assessed or levied by a governmental authority on the Land Parcel, the Premises, or
the  Building  of  which  the  Premises  is  a  part,  including  without  limitation  all  real  estate
taxes,  betterments,  assessments  (ordinary  or  extraordinary),  water  rents,  sewer,  other
charges, or methods of assessment. Any betterment assessment, so-called “rent tax” or any
other tax levied or imposed by any governmental authority assessed to the Land Parcel in
addition to, in lieu of or as a substitute for real estate taxes, shall nevertheless be deemed to
be  real  estate  taxes  for  the  purposes  of  this  Paragraph.  Betterments  and  assessments,  if
includable  in  Taxes  hereunder  shall  be  paid  over  the  longest  period  of  time  permitted  by
governing authority.  The term “Taxes” shall not include any inheritance or estate taxes, or
any taxes on income to the extent applicable to Landlord’s net income. If the Land Parcel is
improved  by  more  than  one  Building,  Taxes  and  any  Tenant  obligation  for  payment  of  a
portion thereof shall be equitably prorated (taking into account any allocation of  assessed
valuation made by governing authority).

(b) In the event that, for any reason, Taxes shall be greater during any Tax Year than  Base
Taxes set forth in Section  1.2,  Tenant  shall  pay  to  Landlord,  as  an  Escalation Charge, an
amount equal to (i) the excess of Taxes over Base Taxes, multiplied by (ii) the Escalation
Factor,  such  amount  to  be  apportioned  for  any  fraction  of  a  Tax  Year  in  which  the
Commencement Date falls or the Term of this Lease ends. Landlord shall provide Tenant

with copies of applicable tax bills in connection with each respective request for payment of
amounts  payable  by  Tenant  pursuant  to  this  Section  8.1(b)  and  in  connection  with
adjustments of the estimated monthly amounts payable by Tenant pursuant to Section 8.1
(c) hereof and at the time of any year end recapitulation of Tenant’s obligations hereunder,
unless the Landlord has previously provided the most up to date tax bills.

(c)  Estimated payments by Tenant on account of Taxes shall be made monthly and at the
time and in the fashion herein provided for the payment of Basic Rent. The monthly amount
so to be paid to Landlord shall be sufficient to provide Landlord by the time tax payments
are  due  a  sum  equal  to  Tenant's  required  payments,  as  reasonably  estimated  by  Landlord
from  time  to  time,  on  account  of  Taxes  for  the  then  current  Tax  Year,  with  minimum
estimates  payments  being  105%  of  the  prior  year’s  actual  tax  payments.  Promptly  after
receipt by Landlord of bills for such Taxes, Landlord shall advise Tenant in writing of the
amount  thereof  and  Landlord’s  computation  of  Tenant's  payment  on  account  thereof.
Landlord shall not adjust the estimated amounts required to be paid by Tenant more than
two (2) times with respect to any Tax Year and at the time of advising Tenant of tenant’s
Tax obligation, Landlord shall provide Tenant with copies of the applicable tax bills upon
which  such  adjustments  are  made.  If  estimated  payments  theretofore  made  by  Tenant  for
the  Tax  Year  covered  by  such  bills  exceed  the  required  payments  on  account  thereof  for
such  Tax  Year,  Landlord  shall  credit  the  amount  of  overpayment   against subsequent
obligations of Tenant on account of Taxes due for the immediately next succeeding month
(with  a  prompt  refund  of  any  balance  to  Tenant  or,  promptly  refund  to  Tenant  such
overpayment if the Term of this Lease has ended and Tenant has no further Tax obligation
to Landlord); but if  the  required payments on account thereof for such Tax Year due from
Tenant under this Lease are greater  than  estimated  payments  theretofore made  on  account
thereof  for such Tax Year, Tenant shall make payment to Landlord within thirty  (30)  days
after being so advised by Landlord. Landlord shall have the same rights and remedies for
the  non-payment  by  Tenant  of  any  payments  due  on  account  of  Taxes  as Landlord  has
hereunder for the failure of Tenant to pay Basic Rent.

8.2

ABATEMENT. If Landlord shall receive any tax refund or reimbursement of Taxes or sum
in lieu thereof with respect to any Tax Year which is not due to vacancies in the Building,
then  out  of  any  balance  remaining  thereof  after  deducting  Landlord's  reasonable out-of-
pocket expenses reasonably incurred in obtaining such refund, Landlord shall pay to Tenant,
provided  no  event  of  Tenant  Default  has  occurred  (which  is  not  remedied  after  required
notice and before expiration of applicable grace and cure periods), an amount equal to such
refund or reimbursement or sum in lieu thereof (exclusive of any interest) multiplied by the
Escalation Factor; provided, that in no event shall Tenant be entitled to receive more  than
the  payments  made  by  Tenant  on  account  of  tax  increases  for  such  Year pursuant  to
paragraph (b) of Section 8.1 or to receive any payments or abatement of Basic Rent if Taxes
for any Tax Year are less than Base Taxes or Base Taxes are abated.

8.3

ALTERNATE TAXES. (a) If some method or type of taxation shall replace the current

method  of  assessment  of  real  estate  taxes  in  whole  or  in  part,  or  the  type  thereof,  or  if
additional types of taxes are imposed upon the Property or Landlord relating to the Property,
Tenant  agrees  that  Tenant  shall  pay  a  proportionate  share  of  the  same  as  an  additional
charge computed in a fashion consistent with the method of computation herein provided, to
the end that Tenant's share thereof shall be, to the maximum extent practicable, comparable
to that which Tenant would bear under the foregoing provisions.
(b) If a tax (other than Federal or State income tax) is assessed on account of the rents or
other charges payable by Tenant to Landlord under this Lease (but not including any tax on
income  or  profits),  Tenant  agrees  to  pay  the  same  as  an  additional  charge  within  ten  (10)
days  after  billing  therefor,  unless  applicable  law  prohibits  the  payment  of  such  tax  by
Tenant.

ARTICLE IX OPERATING
EXPENSES

9.1

DEFINITIONS.  For  the  purposes  of  this  Article,  the  following  terms  shall  have  the
following respective meanings:

(i) Operating Year: Each calendar year in which any part of the Term of this Lease shall
fall.

Operating Expenses: The aggregate costs or expenses incurred by Landlord with respect to
the  operation,  administration,  cleaning,  repair,  maintenance  and  management  of  the
Property  for  the  general  benefit  of  tenants  of  the  Building  including,  without  limitation
those matters set forth in Exhibit D annexed hereto, provided that, if during any portion of
the  Operating  Year  for  which  Operating  Expenses  are  being  computed,  less  than  ninety-
five percent (95%) of Building Rentable Area was occupied by tenants or if Landlord is not
supplying all tenants with the services being supplied hereunder, actual Operating Expenses
incurred  shall  be  reasonably  extrapolated  by  Landlord  on  an  item  by  item  basis  to  the
estimated Operating Expenses that would have been incurred if the Building were ninety-
five percent (95%) occupied for such Operating Year and such services were being supplied to
all tenants, and such extrapolated amount shall, for the purposes hereof, be deemed to be the
Operating Expenses for such Operating Year.

Notwithstanding  anything  to  the  contrary  contained  in  this  Lease,  Tenant’s  aggregate
responsibility  for  Controllable  Operating  Expenses  (defined  below),  in  any  calendar  year
under this Lease shall not increase by more than 5% per year over the immediately preceding
calendar  year,  compounded  yearly,  for  Controllable  Operating  Expenses,  only,  during  the
Term of this Lease, as said term may be extended under this Lease. “Controllable Operating
Expenses”  shall  be  defined  as  all  Operating  Expenses  due  under  this  Lease,  except  the
following “Uncontrollable Operating Expenses”: (i) utilities (e.g. electric, water and sewer),
(ii) real  and  personal  property  taxes  and  assessments,  (iii)  snow  and  ice  removal,  (iv)
landscaping,  (v)  expenditures  for  necessary  capital  repairs  and  replacements,  and  (vii)
insurance premiums and deductibles. Uncontrollable Operating Expenses shall not be subject to
the foregoing 5% per cap.

9.2

9.3

TENANT’S  PAYMENTS.  (a)  In  the  event  that  for  any  Operating  Year  Operating
Expenses  shall  exceed  Base  Operating  Expenses,  Tenant  shall  pay  to  Landlord,  as  an
Escalation Charge, an amount equal to (i) such excess Operating Expenses multiplied by
(ii) the Escalation Factor, such amount to be apportioned for any partial Operating  Year  in
which  the  Commencement  Date  falls  or  the  Term  of  this  Lease  ends.  (b)  Estimated
payments by Tenant on account of Operating Expenses shall be made monthly and at the
time and in the fashion herein provided for the payment of Basic Rent. The monthly amount
so  to  be  paid  to  Landlord  shall  be  sufficient  to  provide  Landlord  by  the  end  of  each
Operating  Year  a  sum  equal  to  Tenant's  required  payments,  as  reasonably  estimated  by
Landlord from time to time during each Operating Year, on account of Operating Expenses
for  such  Operating  Year.  Within  ninety  (90)  days  after  the  end  of  each  Operating  Year,
Landlord  shall  submit  to  Tenant  a  reasonably  detailed  accounting  of  Operating  Expenses
for such Operating Year, with estimated installments being 105% of the prior year’s actual
Operating  Expenses.  If  estimated  payments  theretofore  made  for  such  Operating  Year  by
Tenant  exceed  Tenant's  required  payment  on  account  thereof  for  such  Operating  Year,
Landlord shall credit the amount of overpayment against  subsequent obligations of Tenant
with respect to Operating Expenses due for the next immediately succeeding month (with a
prompt refund of any balance to Tenant or promptly refund to Tenant  such  overpayment if
the Term of this Lease has ended and Tenant has no further obligation to  Landlord), but, if
the  required  payments  on  account  thereof  for  such  Operating  Year  are  greater  than  the
estimated payments (if any) theretofore made on account thereof  for such  Operating Year,
Tenant  shall  make  payment  to  Landlord  within  thirty  (30)  days  after  being  advised  in
writing  by  Landlord  of  Tenant’s  additional  payment  obligation  hereunder.  Landlord  shall
have the same rights and remedies for the nonpayment by Tenant of any payments due on
account of Operating Expenses as Landlord has hereunder for the failure of Tenant to pay
Basic Rent.

Landlord  shall  maintain  such  books  and  records  as  to  Operating  Expenses  in  accordance
with  generally  accepted  accounting  principles.  Landlord  shall  permit  Tenant,  at  Tenant’s
expense and during normal business hours at the offices of Landlord, but only one (1) time
with respect to any Operating Year, to review Landlord’s invoices and statements relating to
the Operating Expenses for the purpose of verifying the Operating Expenses and  Tenant’s
share thereof; provided that notice of Tenant’s desire to so review is given to Landlord not
later  than  thirty  (30)  days  after  Tenant  receives  an  annual  statement  from  Landlord,  and
provided  that  such  review  is  thereafter  commenced  and  prosecuted  by  Tenant  with  due
diligence.  Any  Operating  Expenses  statement  or  accounting  by  Landlord shall  be  binding
and conclusive upon Tenant unless: (a) Tenant duly requests such review within such 30-day
period,  and  (b)  within  three  (3)  months  after  such  review  request,  Tenant  shall  notify
Landlord in writing that Tenant disputes the correctness of such statement,  specifying  the
particular respects in which the statement is claimed to be incorrect. Tenant shall have no
right to conduct a review or to give Landlord notice that it desires to conduct a review at any
time Tenant is in default under the Lease, except Tenant shall have an audit right in the event
the  Tenant  default  is  due  only  to  its  failure  to  make  Operating  Expenses  payments.  If
Tenant’s review of such books and records discloses that Operating Expenses paid by Tenant
for  any  Operating  Year(s)  exceed  Tenant’s  obligation therefor  under  the  Lease,  Landlord
promptly apply such overpayment to Tenant’s rental account;  if  the  Tenant’s  review  of
such  books and  records  discloses  that  Operating

Expenses  paid  by  Tenant  for  any  Operating  Year(s)  is  less  the  amount  previously  paid,
Tenant  shall  promptly  pay  such  underpayment  to  Landlord.  The  party  conducting  the
review shall be compensated on an hourly basis and shall not be compensated based upon a
percentage  of  overcharges  it  discovers.  No  subtenant  shall  have  any  right  to  conduct  a
review, and no assignee shall conduct a review for any period during which such assignee
was  not  in  possession  of  the  Premises.  Tenant  agrees  that  the  results  of  any  Operating
Expense review shall be kept strictly confidential by Tenant and shall not be disclosed to
any other person or entity except to comply with the obligations of law or any government
authority or in connection with any claims brought under this Lease.

INDEMNITY AND PUBLIC LIABILITY INSURANCE

ARTICLE X

10.1 TENANT’S  INDEMNITY.  To  the  maximum  extent  this  agreement  may  be  made  effective
according  to  law,  Tenant  agrees  to  defend,  indemnify and  save  harmless  Landlord  from  and
against  all  claims,  loss,  liability,  costs  and  damages  of  whatever  nature  arising  from  any
default by Tenant under this Lease and the following: (i) from any accident, injury, death or
damage whatsoever to any person, or to the property of any person, occurring in or about the
Premises  after  the  Commencement  Date;  (ii)  from  any  accident,  injury,  death  or  damage
occurring outside of the Premises but on the Property, where such accident, damage or  injury
results from an act or omission on the part of Tenant or Tenant's agents, employees, invitees or
independent  contractors;  or  (iii)  in  connection  with  the  conduct  or  management  of  the
Premises by Tenant or of Tenant's business therein, or anything or work  whatsoever  done, or
any  condition  created  (other  than  by  Landlord)  in  or  about  the  Premises  by  Tenant;  and,  in
any case, occurring after the date of this  Lease,  until the end of the Term of this Lease,  and
thereafter so long as Tenant is in occupancy of the Premises. This indemnity and hold harmless
agreement  shall  include  indemnity  against  all  reasonable  out  of  pocket  costs,  expenses  and
liabilities  incurred  in,  or  in  connection  with,  any  such  claim  or  proceeding  brought  thereon,
and the defense thereof, including, without limitation, reasonable out of pocket attorneys' fees
and costs at both the trial and appellate levels. Nothing contained in this Section 10.1 shall be
deemed or construed to exculpate Landlord from liability arising from its own negligence, or
that  of  any  of  its  employees,  agents,  contractors  or  Invitees.  The  foregoing  indemnification
shall  be  subject  to,  and  shall  exclude  causes  giving  rise  to,  Tenant’s  rights  of  remedy  as  set
forth  in  Section  4.3.  The  provisions  of  this  Section  10.1  shall  survive  the  expiration  or  any
earlier termination of this Lease.

10.2 TENANT’S LIABILITY INSURANCE. (a) Tenant shall obtain and keep in force and effect
during  the  Term,  at  its  own  cost  and  expense,  commercial  general  liability  insurance, on  an
occurrence  basis,  in  an  amount  of  not  less  than  One  Million  Dollars  ($1,000,000),  and a
general aggregate limit of not less than Two Million Dollars ($2,000,000), for  injury,  death,
property  damage  or  other  loss  arising  out  of  any  one  occurrence  or  in  the  aggregate,
protecting  Tenant  as  insured,  and  naming  Landlord,  Landlord’s  Affiliates,  Landlord’s
mortgagees,  property  managers  and  managing  agents  as  additional  insureds  (“Additional
Insureds”),  on  a  primary  and  non-contributory  basis,  against  any  and  all  claims  for  bodily
injury, personal injury, death, property damage or other loss occurring in, upon, adjacent to or
connected with the Premises or any part thereof. The policy shall not contain any intra-

insured  exclusions  as  between  insured  persons  or  organizations,  but  shall  include  coverage
for  liability  assumed  under  this  Lease  as  an  “insured  contract”  for  the  performance  of
Tenant’s indemnity obligations under this Lease. The policy shall cover host liquor liability
exposure,  and  should  contemplate  coverage  for  pollution  liability  claims  arising  out  of
Bodily Injury or Property  Damage  arising  out  of  heat,  smoke  or  fumes  caused by a hostile
fire. A Waiver of Subrogation shall be provided in favor of Landlord, Landlord’s Affiliates
and each as Additional Insureds. Landlord may from time to time during the Term increase
the coverages required of Tenant hereunder to that customarily carried in the area in which
the Premises is located on property similar in use, amenity and size to the Premises; and

(b) Tenant  further  agrees  to  maintain:  (a)  workers’  compensation  insurance  with  a  limit  of
liability as required  by  law  to  be  maintained,  including  a  Waiver  of  Subrogation in favor of
Landlord, Landlord’s Affiliates and each Additional Insured; (b) employer's liability insurance
with a minimum limit of coverage of One Million Dollars ($1,000,000), including a Waiver of
Subrogation  in  favor  of  Landlord,  Landlord’s  Affiliates  and  each  Additional  Insured;  (c)  so
called  “Special  Form”  insurance  coverage  for  all  of  its  contents,  furniture,  furnishings,
equipment,  improvements,  fixtures  and  personal  property  located  at  the  Premises providing
protection in an amount equal to one hundred percent (100%) of the replacement cost basis of
said items, (subject to reasonable deductible amounts) without deduction for  depreciation  of
the  covered  items  and  in  amounts  that  meet  any  co-insurance  clauses  of  the  policies  of
insurance;  (d)  business  interruption  and  extra  expense  insurance  coverage(s)  reasonably
satisfactory  to  Landlord  but  not  to  exceed  Tenant’s  rental  obligations  under  this  Lease;  (e)
automobile  liability  insurance  covering  all  owned,  hired,  and  non-owned  vehicles  with  a
combined single limit of not less than One Million Dollars ($1,000,000); and (f) a minimum
umbrella liability limit of Three Million Dollars ($3,000,000) covering any general commercial
liability,  employer’s  liability,  and  auto  liability  policies,  with  the  Additional  Insureds  and
Waiver  of  Subrogation  provisions  mirroring  the  underlying  policies.  With  respect  to
automobile  liability  insurance,  Landlord,  Landlord’s  mortgagees,  property  managers  and
managing agents shall be afforded additional insured status on a primary and non-contributory
basis,  and  Waiver  of  Subrogation  shall  be  provided  in  favor  of  Landlord  and Landlord’s
Affiliates; and

(c) The  insurance  required  hereunder  shall  be  written  in  form  and  substance  reasonably
satisfactory  to  Landlord  consistent  with  prevailing  requirements  for  similar  properties  and
uses  within  the  location  of  the  Property  by  a  good  and  solvent  insurance  company  of
recognized standing, admitted to do business in Massachusetts, with  a  general  policyholder’s
rating of not less than A- VIII (as rated in the most current Best’s Insurance Reports), which
company  shall  be  reasonably  satisfactory  to  Landlord.  Tenant  shall  procure,  maintain  and
place such insurance and pay all premiums and charges therefor, and upon failure to pay all
premiums  and  charges  when  due  and  payable  (and  without  limiting  any  other  remedies  on
account  thereof),  Landlord  may,  upon  reasonable  prior  notice  to  Tenant  and  Tenant’s
continued  failure  to  procure  the  same,  but  shall  not  be  obligated  to,  procure,  maintain  and
place  such  insurance  or  make  such  payments,  and  in  such  event,  Tenant  agrees  to  pay  the
amount thereof to Landlord on demand, as additional rent hereunder; and

(d) Tenant  shall  cause  to  be  included  in  all  such  insurance  policies  a  provision  to  the  effect
that the same will be non-cancelable except upon thirty (30) days written notice to Landlord.

Prior to the Commencement Date, the appropriate certificates of insurance shall be deposited
with the Landlord. Any renewals, replacements and endorsements shall also be deposited with
Landlord, in the case of renewals, same shall be so deposited at least thirty (30) days prior to
the expiration of the prior policy; and

(e) Landlord and Tenant mutually agree that, with respect to any hazard which is covered by
property insurance then being carried by them, respectively, the one carrying such insurance
and suffering such loss releases the other of and from any and all claims with respect to such
loss,  to  the  extent  of  such  coverage;  and  they  further  mutually  agree  that  their  respective
insurance companies shall have no right of subrogation against the other on account thereof.
Such waiver shall be included in the policy, or such other party shall be named as an additional
insured in such policy, and the other party shall reimburse the party paying such premium the
amount  of  such  extra  premium.  Each  such  policy  which  shall  so  name  a  party  hereto  as  an
additional  insured  shall  contain  the  agreement  of  the  insurer  that  the  policy  will  not  be
canceled without at least thirty (30) days’ notice to both insureds and that the act or omission
of an insured shall not invalidate the policy as to the other insured.

10.3 TENANT'S RISK. To the maximum extent this agreement may be made effective according to
law,  Tenant  agrees  to  use  and  occupy  the  Premises  and  to  use  such  other  portions  of  the
Property as Tenant is herein given the right to use at Tenant's own risk. Landlord shall have
no responsibility or liability for any loss of or damage to Tenant's Removable Property or for
any  inconvenience,  annoyance,  interruption  or  injury  to  business  arising  from  Landlord’s
making any repairs or changes which Landlord is permitted by this Lease or required by law to
make  in  or  to  any  portion  of  the  Premises  or  other  sections  of  the  Property,  or  in  or  to  the
fixtures, equipment or appurtenances thereof, except to the extent caused by the negligence or
willful  misconduct  of  Landlord  or  its  employees,  contractors,  agents  or  invitees.  The
provisions of this Section 10.3 shall be applicable from and after the execution of this Lease
and until the end of the Term of this Lease, and during such further period as Tenant may use
or  be  in  occupancy  of  any part  of  the  Premises  or  of  the  Building.  The  provisions  of  this
Section 10.3 shall survive any expiration or earlier termination of the Term of this Lease.

10.4

INJURY CAUSED BY THIRD PARTIES. To the maximum extent this agreement may be
made  effective  according  to  law,  Tenant  agrees  that  Landlord  shall  not  be  responsible  or
liable  to  Tenant,  or  to  those  claiming  by,  through  or  under  Tenant,  for  any  loss  or  damage
that may be occasioned by or through the acts or omissions of persons (other than Landlord's
employees, agents, contractors or invitees) occupying adjoining premises or any part of the
premises  adjacent  to  or  connecting  with  the  Premises  or  any  part  of  the  Property,  or
otherwise.  The  provisions  of  this  Section  10.4  shall  survive  the  expiration  or  any  earlier
termination of this Lease.

10.5 LANDLORD'S  INSURANCE.  Landlord  shall  maintain  and  keep  in  effect  throughout  the
term  of  this  Lease  (a)  insurance  against  loss  or  damage  to  the  Building  and  other
improvements to the Land Parcel by fire or other casualty as may be included within either
fire  and  extended  coverage  insurance  or  "all-risk"  insurance  in  an  amount  equal  to  the  full
replacement  cost  of  the  Building  (exclusive  of  foundations)  and  (b)  comprehensive  general
liability insurance in amounts reasonably determined by Landlord consistent with prudent

ownership of compatible properties having similar uses within the location of the Property.
Such coverage may be affected directly and/or through the use of blanket insurance coverage
covering more than one location and may contain such deductibles as Landlord may elect.

ARTICLE XI
LANDLORD’S ACCESS TO PREMISES

11.1  LANDLORD'S  RIGHTS.  Landlord  shall  have  the  right  upon  reasonable  advance  oral  or
written  notice  to  Tenant,  of  not  less  than  twenty-four  (24)  hours  or  less  time  based  on  the
mutual agreement of the parties (email and telephonic notice sufficient), to enter the Premises at
all  reasonable  hours  for  the  purposes  of  inspecting  or  making  repairs.  Provided  however,
during  any  time  period  in  which  the  Tenant  is  under  physical  audit  by  any  applicable
professional  organization,  state  or  federal  agency  or  other  compliance  related  event
materially restricting Tenant’s availability, Tenant may require no less than three (3) Business
Days prior oral or written notice from Landlord to access the Premises (email and telephonic
notice sufficient), to enter the Premises at all reasonable hours for the purposes of inspecting
and making repairs. Notwithstanding the forgoing, no notice shall be required (prior Landlord
telephonic notice shall be attempted) in the case of an emergency threatening imminent loss or
damage to persons or property for which Landlord may enter the Premises at any hour of the
day for the purpose of inspecting or making repairs to the same. Landlord shall also have the
right upon such advance notice to make access available at all reasonable hours to prospective
or existing mortgagees, purchasers or tenants of any part of the Property. In exercising its rights
pursuant  to  this  Section  11.1,  Landlord  shall  use  good  faith  efforts  to avoid  unreasonable
interference  with  Tenant's  use  of  the  Premises  and  an  employee  Landlord’s  property
management division shall accompany all service professionals working with Premises.
ARTICLE XII
FIRE, EMINENT DOMAIN, ETC.

12.1 ABATEMENT  OF  RENT.  If  the  Premises,  the  Building,  all  access  thereto  or  more  than
seventy  five  (75%)  percent  of  the  parking  therefor  shall  be  materially  damaged  by  fire  or
casualty,  Basic  Rent  and  Escalation  Charges  payable  by  Tenant  shall  abate  proportionately
for  the  period  in  which,  by  reason  of  such  damage,  there  is  substantial  interference  with
Tenant's  use  of  the  Premises  for  the  Permitted  Use,  having  regard  to  the  extent  to  which
Tenant  may  be  required  to  discontinue  Tenant's  beneficial  use  of  all  or  a  portion  of  the
Premises  for  the  Permitted  Use,  but  such  abatement  or  reduction  shall  end  if  and  when
Landlord shall have substantially restored the Premises (excluding any alterations, additions or
improvements  made  by  Tenant  pursuant  to  Section  5.2),  the  Building,  access  thereto  and
parking therefor to the condition in which they were immediately prior to such damage. If the
Premises, the Building, access  thereto  or  substantial  portion  of  the  parking therefor  shall be
affected by any exercise of the power of eminent domain, Basic Rent and Escalation Charges
payable by Tenant shall be justly and equitably abated and reduced according to the nature and
extent of the loss of beneficial use of the Premises for the Permitted Use suffered by Tenant. In
no  event  shall  Landlord  have  any  liability  for  damages  to  Tenant  for  inconvenience,
annoyance,  or  interruption  of  business  arising  from  such  fire,  casualty  or

eminent domain, except as otherwise expressly provided by this Lease.

12.2 RIGHT OF TERMINATION. If (a) the Premises or the Building are substantially damaged
by  fire  or  casualty  (the  term  "substantially  damaged"  meaning  damage  of  such  a  character
that the same cannot, in the ordinary course, reasonably be expected to be repaired within one
hundred  twenty  (120)  days  from  the  time  the  repair  work  would  commence),  or  (b)  any
mortgagee  then  holding  a  mortgage  on  the  Property  or  any  interest  of  Landlord  therein,
should  require  that  insurance  proceeds  payable  as  a  result  of  a  fire,  casualty  or  action  by
taking authority be applied to the mortgage debt and the balance thereof remaining, if any, is
insufficient  for  the  cost  to  repair  or  restore  the  Premises  and  the  Building  or  (c)  if  any
material part of the Building is taken by any exercise of the right of eminent domain, then, in
the case of (a), (b), or (c) above, Landlord shall have the right to terminate this Lease (even if
Landlord's  entire  interest  in  the  Premises  may  have  been  divested)  by  giving  notice  of
Landlord's  election  so  to  do  to  Tenant  within  sixty  (60)  days  after  the  occurrence  of  such
casualty or the effective date of such taking, whereupon this Lease shall terminate thirty (30)
days after the date of such notice with the same force and effect as if such date were the date
originally established as the expiration date hereof.

12.3 RESTORATION: TENANT'S RIGHT OF TERMINATION. If the Premises is damaged by
fire or casualty or as a result of a taking and if this Lease shall not be terminated pursuant to
Section  12.2,  Landlord  shall  thereafter  use  due  diligence  to  restore  the  Premises,  the
Building, access thereto and parking therefor to substantially its conditions immediately prior to
such  fire  or  casualty,  (exclusive  of  any  alterations,  additions,  or  improvements  made  by
Tenant). If Landlord is then carrying insurance to the extent required under Section 10.5 of
this  Lease,  Landlord's  obligation  to  restore  shall  be  limited  to  the  amount  of  insurance
proceeds  actually  made  available  to  the  Landlord  for  the  purpose  of  restoration  plus  any
deductible amount carried by Landlord, or the condemnation awards actually made available to
Landlord therefor and provided, further, that Landlord shall have no obligation to restore the
Premises or the Building as and to the extent the same cannot be lawfully restored under then
applicable  zoning  and  building  laws.  If,  for  any  reason,  restoration  of  the  Premises,  the
Building,  access  thereto  and  parking  therefor  to  the  condition  required  hereby  shall  not  be
substantially completed as aforesaid within 180 days after the date of casualty or the effective
date of such taking (or the earlier date of Tenant’s loss of beneficial use of the Premises for
Tenant’s Permitted Use) (which 180 day period may not be extended for such periods of time
as Landlord is prevented from proceeding with or completing such restoration for any cause
beyond  Landlord's  reasonable  control,  but  may  be  extended  on  a  day  for  day  basis  for the
period of any delay directly caused by Tenant), Tenant shall have the right to terminate this
Lease by giving notice to Landlord thereof within (30) days after the expiration of such period
(as so extended). Landlord agrees to give notice to Tenant prior to claiming any extension of
time under the preceding sentence. Upon the giving of such notice, this Lease shall (effective
as of a date set forth in such notice which date shall not be sooner than 30 nor later than 60
days  after  the  giving  of  such  notice)  cease  and  come  to  an  end  without  further  liability  or
obligation  on  the  part  of  either  party  unless,  within  such  30-day  period,  Landlord
substantially completes such restoration to the condition required by this Lease. Such right of
termination  shall  be  Tenant's  sole  and  exclusive  remedy  at  law  or  in  equity  for Landlord's
failure to complete such restoration.

Landlord shall not be liable for any inconvenience or annoyance to Tenant or injury to the
business of Tenant resulting in any way from damage from fire or other casualty or the repair
thereof (except as otherwise expressly provided by this Lease), but Tenant shall be entitled to
an abatement of Basic Rent and Escalation Charges as and to the extent expressly provided in
this  Lease.  Tenant  understands  that  Landlord  will  not  carry  insurance  of  any  kind  on
improvements or alterations made by Tenant or on furniture or furnishings or on any fixtures or
equipment removable by Tenant under the provisions of the Lease, and that Landlord shall not
be obligated to repair any damage thereto or replace the same. If Tenant desires any other or
additional repairs for restoration and if Landlord consents thereto, the  same  shall  be  done at
Tenant's expense. Tenant acknowledges that Landlord shall be entitled to the full proceeds of
any insurance coverage, carried by Landlord and Tenant, for damage to the Premises and any
alterations therein (but only to the extent Landlord undertakes restoration and repair thereof
and  excluding  insurance  proceeds  for  Tenant’s  furniture,  fixtures,  equipment  installations,
lost business and costs of relocation.

12.4 AWARD.  Landlord  shall  have  and  hereby  reserves  and  excepts,  and  Tenant  hereby  grants
and assigns to Landlord, all rights to recover for damages to the Property and the leasehold
interest hereby created, and to compensation accrued or hereafter to accrue by reason of such
taking  and  related  damage  or  destruction,  and  by  way  of  confirming  the  foregoing,  Tenant
hereby grants and assigns, and covenants with Landlord to grant and assign to Landlord, all
rights  to  such  damages  or  compensation.  Nothing  contained  herein  shall  be  construed  to
prevent  Tenant  from,  at  its  sole  cost  and  expense,  prosecuting  a  separate  condemnation
proceeding  with  respect  to  a  claim  for  the  value  of  any  of  Tenant's  Removable  Property
installed in the Premises by Tenant at Tenant's expense and for relocation expenses, provided
that  such  action  shall  not  affect  the  amount  of  compensation  otherwise  recoverable  by
Landlord from the taking authority.

ARTICLE XIII DEFAULT

13.1 TENANT'S DEFAULT.  (a) If at any time subsequent to the date of this Lease any one or

more of the following events (herein referred to as a "Default") shall happen:

(i) Tenant shall fail to pay the Basic Rent, Tenant’s Electrical Charge, or Escalation
Charges within five (5) days after written notice that said payment has not been received,
provided that the Tenant  shall  only  be  entitled  to  two  (2)  such  written  notices within any
twelve  (12)  month  period  and  after  the  second  written  notice  within  a  twelve  (12)  month
period if Tenant has an additional failure to pay the Basic Rent, Tenant’s Electrical Charge,
Escalation Charge within five (5) days after the date said payment is due then Tenant shall be
Default; or

(ii) Tenant shall be provided a minimum of ten (10) days’ notice of unpaid amounts
due (email containing such billing from Landlord or Landlord’s construction division  shall
be sufficient) to review and confirm all other sums payable under this Lease, thereafter in

the event Tenant fails to pay such sums payable hereunder within such ten (10) days written
notice  that  said  payment  had  not  been  received,  provided  that  the  Tenant  shall  only  be
entitled to two (2) such written notices within any twelve (12) month period and after the
second written notice within a twelve (12) month period if Tenant has an additional failure to
pay  such  other  sums  payable  under  this  Lease  within  ten  (10)  days  after  the  date  said
payment is due then Tenant shall be Default; or

(iii) Tenant  shall  neglect  or  fail  to  perform  or  observe  any  other  covenant  herein
contained on Tenant's part to be performed or observed, and Tenant shall fail to remedy the
same  within  thirty  (30)  days  after  Landlord  forwarding  a  notice  to  terminate  to  Tenant
specifying such neglect or failure, or if such failure is of such a nature that Tenant cannot
reasonably  remedy  the  same  within  such  thirty  (30)  day  period,  Tenant  shall  fail  to
commence promptly  to remedy the same and to prosecute such remedy to completion with
diligence  and  continuity  for  such  longer  period  reasonably  required  therefor,  but  not  to
exceed ninety (90) days after receive of written notice; or

(iv) Tenant's  leasehold  interest  in  the  Premises  shall  be  taken  on  execution  or  by

other process of law directed against Tenant; or

(v) Tenant  shall  make  an  assignment  for  the  benefit  of  creditors  or  shall  file  a
voluntary petition in bankruptcy or shall be adjudicated bankrupt or insolvent, or shall file
any petition or answer seeking any reorganization, arrangement, composition, readjustment,
liquidation, dissolution or similar relief for itself under any present or future Federal,  State
or  other  statute,  law  or  regulation  for  the  relief  of  debtors,  or  shall  seek  or  consent  to  or
acquiesce in the appointment of any trustee, receiver or liquidator of Tenant or of all or any
substantial  part  of  its  properties,  or  shall  admit  in  writing  its  inability  to  pay its  debts
generally as they become due; or

reorganization,  arrangement,  composition, 

(vi) A  petition  shall  be  filed  against  Tenant  in  bankruptcy  or  under  any  other  law
seeking  any 
liquidation,
dissolution, or similar relief under any present or future Federal, State or other statute, law
or regulation and shall remain undismissed or unstayed for an aggregate of sixty (60) days
(whether or not consecutive), or if any debtor in possession (whether or not Tenant) trustee,
receiver  or  liquidator  of  Tenant  or  of  all  or  any  substantial  part  of  its  properties  or  of  the
Premises  shall  be  appointed  without  the  consent  or  acquiescence  of  Tenant  and  such
appointment  shall  remain  unvacated  or  unstayed  for,  an  aggregate  of  sixty  (60)  days
(whether or not consecutive); or

readjustment, 

(vi)  If  a  Default  of  the  kind  set  forth  in  clauses  (i)  or  (ii)  above  shall  occur  and  if
either  (a)  Tenant  shall  cure  such  Default  within  the  applicable  grace  and  cure  period  after
required notice, if any, or (b) Landlord shall, in its sole discretion, permit Tenant to cure such
Default after the applicable grace period has expired, and an event which would constitute a
similar Default if not cured within the applicable grace and cure period after required notice
shall occur more than two (2) times within the next 365 days, whether or not such event is
cured within the applicable grace and cure period after required notice; then in any such case

(1) if such Default shall occur prior to the Commencement Date, this Lease shall ipso facto,
and without  further act on the part of Landlord, terminate,  and (2) if such Default shall occur
after the Commencement Date, Landlord may terminate this Lease by notice to Tenant, and
thereupon this Lease shall come to an end as fully and completely as if such date, were the
date  herein  originally  fixed  for  the  expiration  of  the  Term  of  this  Lease  (Tenant  hereby
waiving  any  rights  of  redemption)  and  Tenant  will  then  quit  and  surrender  the  Premises  to
Landlord, but Tenant shall remain liable as hereinafter provided.

(b) If  this  Lease  shall  be  terminated  as  provided  in  this  Article,  or  if  any  execution  or
attachment  shall  be  issued  against  Tenant  or  any  of  Tenant's  property  whereupon  the
Premises  shall  be  taken  or  occupied  by  someone  other  than  Tenant,  then  Landlord  may,
without  notice,  re-enter  the  Premises,  either  by  force,  summary  proceedings,  ejectment  or
otherwise,  and remove and dispossess Tenant and all other persons and any and all property
from the same, as if this Lease had not been made, and Tenant hereby waives the service of
notice of intention to re-enter or to institute legal proceedings to that end.

(c) In the event of any termination upon a Default of Tenant as  provided  hereunder,  Tenant
shall  pay  the  Basic  Rent,  Escalation  Charges  and  other  sums  payable  hereunder  up  to  the
time of such termination, and thereafter Tenant, until the end of what would have been the
Term of this Lease in the absence of such termination, and whether or not the Premises shall
have  been  relet,  shall  be  liable  to  Landlord  for,  and  shall  pay  to  Landlord,  as  liquidated
current  damages,  the  Basic  Rent,  Escalation  Charges  and  other  sums  which  would  be
payable hereunder if such termination had not occurred, less the net proceeds, if any, of any
reletting  of  the  Premises,  after  deducting  all  reasonable  out  of  pocket  expenses  in
connection  with  such  reletting,  including,  without  limitation,  all  repossession  costs,
brokerage commissions, reasonable out of pocket legal expenses, reasonable out of pocket
attorneys'  fees,  advertising,  expenses  of  employees,  alteration  costs  and  expenses  of
preparation for such reletting Tenant shall pay such current damages to Landlord monthly
on the days which the Basic Rent would have been payable hereunder if this Lease had not
been terminated.

(d) At  any  time  after  such  termination,  whether  or  not  Landlord  shall  have  collected  any
such current damages, as liquidated final damages and in lieu of all such current damages
beyond  the  date  of  such  demand,  at  Landlord's  election,  Tenant  shall  pay  to  Landlord  an
amount equal to the excess, if any, of the Basic Rent, Escalation Charges and other sums as
hereinbefore  provided  which  would  be  payable  hereunder  from  the  date  of  such  demand
(assuming that, for the purposes of this paragraph, annual payments by Tenant on account of
Taxes  and  Operating  Expenses  would  be  the  same  as  the  payments  required  for  the
immediately preceding Operating Year or Tax Year) for what  would  be  the  then  unexpired
Term of this Lease if the same had remained in effect, over the then fair net rental value of
the Premises for the same period.

(e) In  the  case  of  any  Default,  re-entry,  expiration  and  dispossession  by  summary
proceeding or otherwise, Landlord may (i) re-let the Premises or any part or parts thereof,
either in the name of Landlord or otherwise, for a term or terms which may at Landlord's

option be equal to or less than or exceed the period which would otherwise have constituted
the balance of the Term of this Lease and may grant concessions or free rent to the extent
that Landlord considers advisable and reasonably necessary to re-let the same and (ii) may
make such reasonable alterations, repairs and decorations in the Premises as Landlord in its
sole reasonable judgment considers advisable and necessary for the purpose of  reletting  the
Premises; and the making of such alterations, repairs and decorations shall not operate or be
construed to release Tenant from liability hereunder as aforesaid. Landlord shall in no event
be liable  in  any way whatsoever  for  failure to  re-let  the  Premises,  or,  in  the  event  that the
Premises  are  re-let,  for  failure  to  collect  the  rent  under  such  re-letting.  Tenant  hereby
expressly waives any and all rights of redemption granted by or under any present or future
laws  in  the  event  of  Tenant  being  evicted  or  dispossessed,  or  in  the  event  of  Landlord
obtaining  possession  of  the  Premises,  by  reason  of  the  violation  by  Tenant  of  any  of  the
covenants and conditions of this Lease resulting in a termination of this Lease for Default.

(f) The specified remedies to which Landlord may resort hereunder are not intended to be
exclusive of any remedies or means of redress to which Landlord may at any time be entitled to
lawfully, and Landlord may upon a Default by Tenant invoke any remedy (including the
remedy of specific performance) allowed at law or in equity as if specific remedies were not
herein provided for. All reasonable out of pocket costs and expenses incurred by or on behalf of
Landlord  (including,  without  limitation,  reasonable  out  of  pocket  attorneys’  fees  and
expenses) in enforcing its rights hereunder and/or occasioned by any Default of Tenant shall
be paid by Tenant.

13.2 LANDLORD’S DEFAULT. Landlord shall in no event be in  default  in  the  performance of
any  of  Landlord’s  obligations  hereunder  unless  and  until  Landlord  shall  have  failed  to
perform  such  obligations  within  thirty  (30)  days,  or  such  additional  time  as  is  reasonably
required  to  correct  any  such  default,  after  written  notice  by  Tenant  to  Landlord  properly
specifying  wherein  Landlord  has  failed  to  perform  any  such  obligation.  It  is  the  express
understanding  and  agreement  of  the  parties  and  a  condition  of  Landlord’s  agreement  to
execute this Lease that in no event shall Tenant have the right to terminate this Lease or seek
an  abatement  to  or  offset  from  Basic  Rent  or  Escalation  Charges  as  a  result  of  Landlord's
default, but Tenant shall be entitled to seek all other remedies, at law or equity, as a result of
such  default.  Tenant  hereby  waives  its  right  to  recover  punitive,  special  or  consequential
damages  arising  out  of  any  act,  omission  or  default  by  Landlord  (or  any  party  for  whom
Landlord is responsible). Except  as  otherwise  expressly  provided  by  this  Lease,  this  Lease
and the obligations of Tenant hereunder shall not be affected or impaired because Landlord is
unable to fulfill any of its obligations hereunder or is delayed in doing so, if such inability or
delay  is  caused  by  reason  of  a  Force  Majeure  Event  (as  defined  below),  and,  except  as
otherwise  expressly  provided  by  this  Lease,  the  time  for  Landlord's  performance  shall  be
extended for the period of any such delay. Any  claim,  demand,  right  or  defense  by  Tenant
that  arises  out  of  this  Lease  or  the  negotiations  which  preceded  this  Lease  shall  be  barred
unless  Tenant  commences  an  action  thereon,  or  interposes  a  defense  by  reason  thereof,
within six (6) months after the date of the inaction, omission, event or action that gave rise to
such claim, demand, right or defense, or (ii) if such inaction, omission, event or action was
not discoverable within such six (6) months, then within sixty (60) days after its discovery.
Tenant shall look solely to the equity of the Landlord in the Building and the Land

Parcel  and  all  proceeds,  net  income  and  profits  therefore  for  the  satisfaction  of  Tenant’s
remedies. As used herein, a “Force Majeure Event” shall be any delay caused by or resulting
from  acts  of  God,  war,  civil  commotion,  fire,  flood  or  other  casualty,  labor  difficulties,
shortages  of  or  inability  to  obtain  labor,  materials  or  equipment,  government  regulations,
unusually severe weather, or other causes beyond such party’s reasonable control.

ARTICLE XIV
MISCELLANEOUS PROVISIONS

14.1 EXTRA  HAZARDOUS  USE.  Tenant  covenants  and  agrees  that  Tenant  will  not  do  or
permit its employees, agents, contractors or invitees to do anything in or upon the Premises or
the Property, or bring in anything or keep anything therein, which shall increase the  rate of
property or liability insurance on the Premises or on the Property above the  standard  rate
applicable to premises being occupied for the Permitted Use; and Tenant further agrees that,
in  the  event  that  Tenant  shall  do  any  of  the  foregoing,  Tenant  will  promptly  pay  to
Landlord,  on  demand,  any  such  increase  resulting  therefrom,  which  shall  be  due  and
payable as an additional charge hereunder.

14.2 WAIVER.  (a)  Failure  on  the  part  of  Landlord  or  Tenant  to  complain  of  any  action  or
non•action on the part of the other, no matter how long the same may continue, shall never
be  a  waiver  by  Tenant  or  Landlord,  respectively,  of  any  of  the  other's  rights  hereunder.
Further, no waiver at any time of any of the provisions hereof by Landlord or Tenant shall be
construed as a waiver of any of the other provisions hereof, and a waiver at any time of any
of  the  provisions  hereof  shall  not  be  construed  as  a  waiver  at  any  subsequent  time  of  the
same provisions. The consent or approval of Landlord or Tenant to or of any action by the
other  requiring  such  consent  or  approval  shall  not  be  construed  to  waive  or  render
unnecessary Landlord's or Tenant's consent or approval to or of any subsequent  similar  act
by the other.

(b) No payment by Tenant, or acceptance by Landlord, of a lesser amount than shall be due
from  Tenant  to  Landlord  shall  be  treated  otherwise  than  as  a  payment  on  account  of  the
earliest  installment  of  any  payment  due  from  Tenant  under  the  provisions  hereof.  The
acceptance  by  Landlord  of  a  check  for  a  lesser  amount  with  an  endorsement  or  statement
thereon, or upon any letter accompanying such check, that such lesser amount is payment in
full, shall be given no effect, and Landlord may accept such check without prejudice to any
other rights or remedies which Landlord may have against Tenant.

14.3 COVENANT  OF  QUIET  ENJOYMENT.  Subject  to  the  terms  and  provisions  of  this
Lease, on payment of the Basic Rent and Escalation Charges if and when due and payable
under this Lease and observing, keeping and performing all of the other terms and provisions of
this  Lease  on  Tenant's  part  to  be  observed,  kept  and  performed,  Tenant  shall  lawfully,
peaceably  and  quietly  have,  hold,  occupy  and  enjoy  the  Premises  during  the  term  hereof,
without hindrance or ejection by any persons lawfully claiming under Landlord to have title to
the Premises superior to Tenant. The foregoing covenant of quiet enjoyment is in lieu of any
other covenant, express or implied.

14.4 LANDLORD'S LIABILITY. (a) Tenant specifically agrees to look solely to Landlord's then
equity interest  in  the  Property  at  the  time  owned,  and  all  proceeds,  net  income  and  profit
therefrom,  for  recovery  of  any  judgment  from  Landlord;  it  being  specifically  agreed  that
Landlord  (original  or  successor)  shall  never  be  personally  liable  for  any  such  judgment,  or
for the payment of any monetary obligation to Tenant.

(b) With respect to any services or utilities to be furnished by Landlord to Tenant, Landlord shall in
no  event  be  liable  for  failure  to  furnish  the  same  when  prevented  from  doing  so  by  Force
Majeure, strike, lockout, breakdown, accident, order or regulation of or by any governmental
authority, or failure of supply, or inability by the exercise of reasonable diligence to obtain
supplies,  parts  or  employees  necessary  to  furnish  such  services,  or  because  of  war  or  other
emergency, or for any cause beyond Landlord's reasonable control, or for any cause due to
any act or neglect of Tenant or Tenant's servants,  agents, employees, licensees or  any person
claiming  by,  through  or  under  Tenant;  nor  shall  any  such  failure  give  rise  to  any  claim  in
Tenant's  favor  that  Tenant  has  been  evicted,  either  constructively  or  actually,  partially  or
wholly.

(c) In no event shall Landlord ever be liable to the Tenant for any loss of business or any other

indirect or consequential damages suffered by Tenant from whatever cause.

(d) With  respect  to  any  repairs  or  restoration  which  are  required  or  permitted  to  be  made  by
Landlord, the same may be made during normal business hours and Landlord shall have no
liability  for  damages  to  Tenant  for  inconvenience,  annoyance  of  interruption  of  business
arising therefrom. In exercising its rights hereunder, Landlord shall use good faith  efforts  to
avoid unreasonable interference with Tenant's use of the Premises for the Permitted Use.
(e) In no event shall Landlord be liable for any breach of any term, condition or covenant during
the Term unless the same shall occur during and within the period of time that it is the owner of
the Building. In no event and under no circumstances shall Landlord be liable to Tenant for
any consequential  or  special  damages  in  connection  with  any  act  of  Landlord,  its  agents,
employees, invitees or independent contractors or otherwise.

14.5 NOTICE  TO  MORTGAGEE  OR  GROUND  LESSOR.  After  receiving  written  notice
from any person, firm or other entity that it holds a mortgage or a ground lease which includes
the Premises, no notice  from  Tenant  to  Landlord  alleging  any  default  by  Landlord shall
be  effective  unless  and  until  a  copy  of  the  same  is  given  to  such  holder  or  ground  lessor
(provided  Tenant  shall  have  been  furnished  with  the  name  and  address  of  such  holder  or
ground  lessor),  and  the  curing  of  any  of  Landlord’s  defaults  within  applicable  cure  periods
under this Lease by such holder or ground lessor shall be treated as performance by Landlord.

14.6 ASSIGNMENT  OF  RENTS  AND  TRANSFER  OF  TITLE.  (a)  With  reference  to  any
assignment  by  Landlord  of  Landlord's  interest  in  this  Lease,  or  the  rents  payable  hereunder,
conditional in nature or otherwise, which assignment is made to the holder of a mortgage on
property which includes the Premises, Tenant agrees that the execution thereof by Landlord,
and  the  acceptance  thereof  by  the  holder  of  such  mortgage,  shall  never  be  treated  as  an
assumption by such holder of any of the obligations of Landlord hereunder unless such holder
shall, by notice sent to Tenant, specifically otherwise elect and that, except as aforesaid,  such
holder  shall  be  treated  as  having  assumed  Landlord's  obligations  hereunder  only  upon  (i)
foreclosure of such holder's mortgage (but only if such holder shall purchase such property at

foreclosure), or (ii) the entry and taking of possession of the Property by such holder (but only
as to matters which shall accrue or arise during the period of possession by such holder).

(b) In  no  event  shall  the  acquisition  of  Landlord's  interest  in  the  Property  by  a  purchaser
which, simultaneously therewith, leases Landlord's entire interest in the Property back to the
seller thereof be treated as an assumption  by  operation  of  law  or  otherwise,  of  Landlord's
obligations hereunder, but Tenant shall look solely to such seller-lessee, and its successors
from time to time in title, for performance of Landlord's obligations hereunder. In any such
event,  this  Lease  shall  be  subject  and  subordinate  to  the  lease  to  such  purchaser.  For  all
purposes,  such  seller•lessee,  and  its  successors  in  title,  shall  be  the  Landlord  hereunder
unless and until Landlord’s position shall have been assumed by such purchaser lessor.

(c) Except  as  provided  in  paragraph  (b)  of  this  Section,  in  the  event  of  any  transfer  of
title  to  the  Property  by  Landlord,  Landlord  shall  thereafter  be  entirely  freed  and  relieved
from the performance and observance of all covenants and obligations hereunder which are to
be  performed  or  observed  from  and  after  the  date  of  such  transfer,  provided  Landlord’s
obligations with respect to any Security Deposit shall remain in effect until actual delivery
thereof to its successor in title.

14.7 RULES AND REGULATIONS. Tenant  shall  abide  by  rules  and  regulations  from  time  to
time  established  by  Landlord,  it  being  agreed  that  such  rules  and  regulations  will  be
established and applied by Landlord in a non-discriminatory fashion, such that all rules and
regulations shall be generally applicable to other tenants of the Building of similar nature to
the Tenant named herein. Landlord agrees to use reasonable efforts to ensure that any such
rules and regulations are uniformly enforced, but Landlord shall not be liable to Tenant for
violation  of  the  same  by  any  other  tenant  or  occupant  of  the  Building,  or  persons  having
business  with  them.  In  the  event  that  there  shall  be  any  conflict  between  such  rules  and
regulations and the provisions of this Lease, the provisions of this Lease shall control. The
current  rules  and  regulations  of  the  Building  are  attached  as  Exhibit  E.  In  each  instance
where  Tenant’s  compliance  with  Landlord  rules  and  regulations  is  required  in  this  Lease,
such requirement shall be subject to this Section 14.7.

14.8 ADDITIONAL CHARGES. If Tenant shall fail to pay when due any sums under this Lease
designated  or  payable  as  an  additional  charge,  Landlord  shall  have  the  same  rights  and
remedies as Landlord has hereunder for failure to pay Basic Rent.

14.9

INVALIDITY OF PARTICULAR PROVISIONS. If any term or provision of this Lease, or
the application thereof  to  any  person  or  circumstance  shall,  to  any  extent,  be invalid or
unenforceable, the remainder  of  this  Lease, or  the  application  of  such  term  or provision  to
persons  or  circumstances  other  than  those  as  to  which  it  is  held  invalid  or  unenforceable,
shall not be affected thereby, and each term and provision of this Lease shall be valid and be
enforced to the fullest extent permitted by law.

14.10 PROVISIONS  BINDING,  ETC.  Except  as  herein  otherwise  provided,  the  terms  hereof
shall  be  binding  upon  and  shall  inure  to  the  benefit  of  the  successors  and  assigns,
respectively, of Landlord and Tenant and, if Tenant shall be an individual, upon and to his

heirs, executors, administrators, successors and assigns. Each term and each provision of this
Lease to be performed by Tenant shall be construed to be both a covenant and a condition.
The  reference  contained  to  successors  and  assigns  of  Tenant  is  not  intended  to  constitute  a
consent to assignment by Tenant, but has reference only to those instances in which Landlord
may later give consent to a particular assignment as required by those provisions of Article
VI hereof or where assignment by Tenant is expressly permitted by this Lease.

14.11 RECORDING. Tenant agrees not to record this Lease, but each party hereto agrees, on the
request of the other, to execute a so-called notice of lease in form recordable and complying
with  applicable  law  and  reasonably  satisfactory  to  Landlord’s  attorneys.  In  no  event  shall
such  document  set  forth  the  rent  or  other  charges  payable  by  Tenant  under  this  Lease;  and
any  such  document  shall  expressly  state  that  it  is  executed  pursuant  to  the  provisions
contained in this Lease, and is not intended to vary the terms and conditions of this Lease.

14.12 NOTICES. Whenever, by the terms of this Lease, notices, consents or approvals and other
communications  ("notices")  shall  or  may  be  given  either  to  Landlord  or  to  Tenant,  such
notices shall be in writing and shall be sent by (i) registered or certified mail, return receipt
requested, postage and handling prepaid or (ii) reputable overnight courier with  evidence  of
receipt,  postage  and  handling  prepaid,  or  (iii)  by  hand  delivery  with  acknowledgment  of
receipt; or (iv) by electronic mail or facsimile transmission with confirming receipt:

If  intended  for  Landlord,  addressed  to  Landlord  at  465  Waverley  Oaks  Road,  Suite  500,
Waltham,  MA  02452(or  to  such  other  address  or  addresses  within  the  continental  United
States  as  may  from  time  to  time  hereafter  by  designated  by  Landlord  by  like  notice),  with
electronic mail to Robert L. Duffy, Jr. at bobduffy@duffyproperties.com.

If  intended  for  Tenant,  addressed  to  Tenant  at  Tenant's  Original  Address  until  the
Commencement  Date  and  thereafter  to  the  Premises  (or  to  such  other  address  or  addresses
within  the  continental  United  States  as  may  from  time-to-time  hereafter  be  designated  by
Tenant   by   like   notice),   with   electronic   mail   to

at

.

All  such  notices  shall  be  effective  upon  receipt  thereof  by  the  addressee  provided  that  the
same are received in ordinary course at the address to which the same were sent. Provided
further however that rejection or refusal to accept or inability to deliver because of change of
address (without proper notice of such change of notice address as required hereunder) shall
be deemed receipt of the notice sent as of the first day of refusal or rejection or the first date of
attempted delivery to the address specified herein in the case of a change of notice address
without proper notice of such change of address as aforesaid.

14.13 WHEN LEASE BECOMES BINDING. The submission of this document for examination
and  negotiation  does  not  constitute  an  offer  to  lease,  or  a  reservation  of,  or  option  for,  the
Premises, and this document shall become effective and binding only upon the execution and

  
 
  
 
delivery  hereof  by  both  Landlord  and  Tenant.  All  negotiations,  considerations,
representations and understandings between Landlord and Tenant are incorporated herein and
this Lease expressly supersedes any proposals or other written documents relating hereto. This
Lease may be modified or altered only by written agreement between Landlord and Tenant,
and no act or omission of any employee or agent of Landlord shall alter, change or modify
any of the provisions hereof.

14.14 PARAGRAPH  HEADINGS.  The  paragraph  headings  throughout  this  instrument  are  for
convenience and reference only, and the words contained therein shall in no way be held to
explain,  modify,  amplify  or  aid  in  the  interpretation,  construction,  or  meaning  of  the
provisions of this Lease.

14.15 RIGHTS OF MORTGAGEE OR GROUND LESSOR. This Lease shall be subordinate to
any mortgage or ground lease from time to time encumbering the Premises, whether executed
and delivered prior to or subsequent to the date of this Lease, if the holder of such mortgage
or ground lease shall so elect, provided that (i) the  holder  shall  execute  a subordination  and
non-disturbance agreement in favor of Tenant to provide that in the event of the foreclosure of
such mortgage or the exercise of rights of possession under such ground lease, Tenant's rights
under  this  Lease  shall  not  be  affected  so  long  as  Tenant  continues  to  pay the  Basic  Rent,
Escalation  Charges  and  other  sums  and  charges  provided  for  in  this  Lease and  otherwise
complies  with  each  and  every  one  of  its  obligations  hereunder  and  otherwise  in  form
reasonably  satisfactory  to  Landlord  and  Tenant  (an  “SNDA”),  and  (ii)  the  lien  of  such
mortgage  shall  not  cover  any  of  Tenant's  personal  property  or  any  of  the  Tenant's  fixtures,
furnishings, alterations  or improvements installed by Tenant or Tenant's contractors and which
Tenant is permitted to remove from the Premises pursuant to the terms of this Lease. Subject
to the foregoing, if this Lease is subordinate to any mortgage or  ground  lease and the holder
thereof (or successor) shall succeed to the interest of Landlord, at the election of such holder
(or successor) Tenant shall attorn to such holder and this Lease shall continue in full force and
effect  between  such  holder  (or  successor)  and  Tenant.  Tenant  agrees  to  execute  such
instruments of subordination subject to the aforesaid condition or attornment in confirmation
of the foregoing agreement (provided such holder shall agree to assume in writing all of the
obligations of the Landlord under this Lease) as such holder may request.

14.16 STATUS  REPORT.  Recognizing  that  Landlord  may  find  it  necessary  to  establish  to  third
parties, such as accountants, banks, mortgagees, ground lessors, or the like, the then current
status  of  performance  of  Tenant  or  Landlord  hereunder,  Tenant  on  the  written  request  of
Landlord  made  from  time  to  time,  will  within  ten  (10)  Business  Days  of  any  such  request
furnish  to  Landlord,  or  the  holder  of  any  mortgage  or  ground  lease  encumbering  the
Premises, or to any other  third  party  designated  by  Landlord  and  holding  an  interest in the
Premises, as the case may be, a statement of the status of any matter pertaining to this Lease,
including, without limitation, acknowledgment that (or the extent to which) each party is in
compliance with its obligations under the terms of this Lease. From time to time, upon not
less  than  fifteen  (15)  days  prior  written  request,  Landlord  shall  execute,  acknowledge  and
deliver  to  Tenant,  a  statement  in  writing  certifying:  (a)  that  the  Lease  is  unamended  (or
specifying  any  amendments);  (b)  that  this  Lease  is  in  full  force  and  effect  (if  such  be  the
case); (c) the dates through which Basic Rent and Escalation Charges and any other payments

have  been  paid;  (d)  any  claims,  defenses,  offsets  and  counterclaims  which  Landlord  has  at
the time of execution of such statement or that there are none; and (e) such other data as may
reasonably requested by Tenant.

14.17 SECURITY DEPOSIT. Simultaneously with the execution and delivery of this Lease, Tenant
shall deliver to Landlord a security deposit (the “Security Deposit”), which Security Deposit
shall be in the Security Deposit Amount (as defined in Section 1.2) and shall consist either of
cash or of a clean, irrevocable letter of credit  satisfactory in a form  similar to Exhibit H, and
issued by an FDIC insured bank located in Boston reasonably satisfactory to Landlord in favor
of the Landlord.  During the Term hereof, and any extensions thereof, and for ninety
(90) days after the expiration of the Term, or for so long thereafter as Tenant is in possession of
the  Leased  Premises  or  has  unsatisfied  obligations  hereunder  to  Landlord,  the  Security
Deposit shall be security for the full and timely performance of Tenant’s obligations under this
Lease;  which  cash  may be  used  or  letter  of  credit  drawn  upon  by  Landlord  in  the  event  of
Default  and  applied  from  time  to  time  against  outstanding  obligations  of  Tenant  hereunder
without  notice  or  demand.  Tenant  shall  have  no  right  to  require  Landlord  to  so  apply  the
Security  Deposit,  nor  shall  Tenant  be  entitled  to  credit  the  same  against  rents  or  other  sums
payable hereunder; no interest shall accrue thereon.  If the Security Deposit is in the form of a
letter  of  credit,  during  the  entire  Term  hereof,  including  any  extension  thereof,  Tenant  shall
cause said letter of credit to be renewed, in identical form to that delivered herewith, no later
than  thirty  (30)  days  prior  to  the  date  of  expiration  of  same.  Without  limiting  any  other
remedies  of  Landlord,  in  the  event  that  Tenant  fails  to  renew  any  letter  of  credit  given
hereunder at least thirty (30) days prior to the date of expiration thereof, then Landlord shall
have the right to draw down the entire amount of said letter of credit and hold such sums as a
cash deposit. If and to the extent that Landlord makes such use of the Security Deposit, or any
part  thereof,  the  sum  so  applied  by  Landlord  (from  cash  or  from  a  drawing  on  the  letter  of
credit) shall be restored to the Security Deposit, in cash, by Tenant upon notice from Landlord,
and failure to pay Landlord the amount to be so restored (within the grace period applicable to
Fixed Rent hereunder) shall be a Default hereunder giving rise to all of Landlord’s rights and
remedies  applicable  to  a  Default  in  the  payment  of  rent.  In  the  event  of a  change  of
circumstance relating to the bank issuing the letter of credit, or Landlord otherwise reasonably
believes the financial conditions of the issuing bank has been degraded, Landlord reserves the
right to require Tenant to replace the letter of credit from time to time with a substitute similar
letter of credit issued by another bank satisfactory to Landlord. No trust relationship is created
herein  between  Landlord  and  Tenant  with  respect  to  said  Security  Deposit.  Tenant
acknowledges that the Security Deposit is not an advance payment of any kind or a measure of
Landlord's damages in the event of Tenant's Default; Landlord shall not be obliged to keep the
Security Deposit as a separate fund or pay interest thereon but may commingle the Security
Deposit  with  its  own  funds.  Tenant  hereby  waives  the  provisions  of any  law  which  is
inconsistent with this Section 14.17.

14.18 REMEDYING DEFAULTS. Landlord shall have the right, but shall not be required, to pay
such sums or to do any act which requires the expenditure of monies which may be necessary or
appropriate by reason of the failure or neglect of Tenant to perform any of the provisions of
this Lease following Default therein by Tenant, and in the event of the exercise of such right
by  Landlord  following  a  Default  therein  by  Tenant,  Tenant  agrees  to  pay  to  Landlord
forthwith upon demand all such sums, together with interest thereon at a rate equal to twelve

percent  (12%)  as  an  additional  charge.  Any  payment  of  Basic  Rent,  Escalation  Charges  or
other sums payable hereunder not paid within two (2) Business Days of when due shall, at
the  option  of  Landlord,  bear  interest  at  a  per  annum  rate  equal  to  5%  from  the  due  date
thereof and shall be payable forthwith on demand by Landlord, as an additional charge.
14.19 HOLDING OVER. Any holding over by Tenant after the expiration or earlier termination of
the Term of this Lease shall be treated as a monthly tenancy at sufferance at a rate equal one
hundred fifty (150%) for the first (1st) month, and thereafter two hundred (200%) for every
month thereafter of the Basic Rent and Escalation Charges in effect on the date immediately
preceding such expiration or earlier termination date. Beginning in the second (2nd) month of
holding over, Tenant shall also pay to Landlord all damages, direct and/or indirect (including
any  loss  of  a  tenant  or  rental  income),  sustained  by  reason  of  any  such  holding  over.
Otherwise, such holding over shall be on the terms and conditions set forth in this Lease  as
far as applicable (except there shall be no options to extend the Term if  any be contained  in
this Lease).

14.20 SURRENDER OF PREMISES. Upon the expiration or earlier termination of the Term of
this  Lease,  Tenant  shall  peaceably  quit  and  surrender  to  Landlord  the  Premises  in  neat  and
clean  condition  and  in  good  order,  condition  and  repair,  together  with  all  alterations,  and
additions  and  improvements,  including,  without  limitation,  data  wiring  and  cabling,  which
may  have been made or installed in, on or to the Premises prior to or during the Term of this
Lease,  excepting  only  ordinary  wear  and  use  and  damage  by  fire,  other  casualty  or  as  the
result of eminent domain proceedings for which, under other provisions of this Lease, Tenant
has  no  responsibility  of  repair  and  restoration.  Tenant  shall  remove  all  of  Tenant’s
Removable Property and, to the extent specified by Landlord in the consent to alterations, all
alterations and additions made by Tenant and all partitions wholly within the Premises  and
shall repair any damage to the Premises or the Building caused by such removal.  To the extent
Landlord requires removal of alterations or additions permitted to be made by Tenant without
Landlord  prior  written  consent,  Landlord  shall  submit  such  removal  request  in  writing  to
Tenant at least thirty (30) days prior to expiration or termination of the Lease.  Any Tenant's
Removable Property which shall remain in the Building or on the Premises after the expiration
or  termination  of  the  Term  of  this  Lease  shall  be  deemed  conclusively  to  have  been
abandoned, and either may be retained by Landlord as its property or may be disposed of in
such manner as Landlord may see fit, at Tenant's sole reasonable cost and expense.

14.21 APPROVALS.  Tenant  shall  reimburse  Landlord,  as  additional  rent,  promptly  on  demand,
and in all events within thirty (30) days of notice of demand for all reasonable out-of-pocket
expenses,  including  but  not  limited  to  legal,  engineering  or  other  professional  services  or
expenses incurred by Landlord in connection with any request(s) by Tenant for consents or
approvals  hereunder  made  from  and  after  the  Commencement  Date  (but  in  no  event  in
connections  with  Landlord’s  Work,  fitup  and  delivery  of  the  Premises  to  Tenant  prior
thereto).  Landlord  shall  not,  in  connection  with  any  request(s)  by  Tenant  for  consents  or
approvals  under  this  Lease,  unreasonably  withhold,  delay,  or  condition  such  consent  or
approval.

14.22 BROKERAGE. Each of Landlord and Tenant warrants and represents that it has dealt with no
broker in connection with the consummation of this Lease, other than NAI Hunneman

(Landlord)  and  Jones  Lang  LaSalle  (Tenant),  and  in  the  event  of  any  brokerage  claims  against
either party predicated upon prior dealings with the other party, such party agrees to defend the
same and indemnify the other against any such claim. Landlord shall be responsible for payment of
all finder’s fees, commissions and costs and expenses due said named brokers.

14.23 SPECIAL TAXATION PROVISIONS.  Landlord shall have the right at any time and from
time to time, to amend the provisions of this Lease if Landlord is advised by its counsel that
all or any portion of the monies paid by Tenant to Landlord hereunder are, or may be deemed to
be,  unrelated  business  income  within  the  meaning  of  the  United  States  Internal  Revenue
Code, or regulation issued thereunder, and Tenant agrees that it will execute all documents or
instruments reasonably necessary to effect such amendment or amendments, provided that no
such amendment shall result in an increase in the overall economics of this lease for Tenant,
and provided that no such amendment shall result in Tenant receiving under the provisions of
this Lease less services or amenities than it is entitled to receive nor services or amenities of
a lesser quality, or otherwise adversely interfere with or affect Tenant's use of the Premises for
the Permitted Use or create any greater liability or obligation for Tenant.

Anything contained in the foregoing provisions of this Lease (including,  without  limitation,
Article  VI  hereof)  to  the  contrary  notwithstanding,  neither  Tenant  nor  any  other  person
having an interest in the possession, use, occupancy or utilization of the Premises shall enter
into  any  lease,  sublease,  license,  concession  or  other  agreement  for  use,  occupancy  or
utilization  of space in the Premises which provides for rental or other payment for such use,
occupancy or utilization based, in whole or in part, on the net income or profits derived by
any person from the premises leased, used, occupied or utilized (other than an amount based
on a fixed percentage or percentages of receipts or sales), and any other agreements shall be
absolutely void and ineffective as a conveyance of any right or interest in the possession, use,
occupancy or utilization of any part of the Premises.

14.24 HAZARDOUS MATERIALS. Tenant shall not (either with or without negligence) cause or
permit its employees, agents or contractors to cause the escape, disposal,  release  or  threat of
release of any biologically or chemically active or other Hazardous Materials (as said term is
hereafter defined) on, in, upon or under the Property or the Premises. Tenant shall not allow
the generation, storage, use or disposal of such Hazardous Materials by its employees, agents
or contractors in any manner prohibited by law, nor allow to be brought into the Property by
its  employees,  agents  or  contractors  any  such  Hazardous  Materials  except  for  use  in  the
ordinary  course  of  Tenant's  business,  and  (if  other  than  customary  office  and  cleaning
products) then only after written notice is given to Landlord of the identity of such Hazardous
Materials. Hazardous  Materials  shall  include,  without  limitation,  any  material or substance
which is (i)  petroleum, (ii) asbestos, (iii) designated as  a "hazardous substance" pursuant  to
Section  311  of  the  Federal  Water  Pollution  Control  Act,  33  U.S.C.  §1251  et  seq.  (33
U.S.C.  §  1321)  or  listed  pursuant  to  §307  of  the  Federal  Water  Pollution  Control Act  (33
U.S.C. § 1317), (iv) defined as a "hazardous waste" pursuant to Section 1004 of the Resource
Conservation and Recovery Act, 42 U.S.C. § 6901 et seq. (42 U.S.C. § 6903), (v) defined as a
"hazardous  substance"  pursuant  to  Section  101  of  the  Comprehensive  Environmental
Response, Compensation,  and  Liability  Act,  42  U.S.C.  § 9601 et seq. (42 U.S.C.  § 9601),
as amended, or (vi) defined as "oil" or a "hazardous waste", a "hazardous

substance",  a  "hazardous  material"  or  a  "toxic  material"  under  any  other  law,  rule  or
regulation  applicable  to  the  Property,  including,  without  limitation,  Chapter  21E  of  the
Massachusetts General Laws, as amended. If any lender or governmental agency shall during
the Term require testing to ascertain whether or not there has been any release of Hazardous
Materials by Tenant in the Premises, in each case , of which such party in good faith and on
reasonable belief of Tenant’s violation of its obligations hereunder, then the reasonable costs
thereof shall be reimbursed by Tenant to Landlord upon  demand  as  additional  charges but
only  if  such  requirement  applies  solely  to  the  Premises  or  is  the  result  of  the  acts  or
omissions  of Tenant  during  the  Term  of   this   Lease.   In   addition, Tenant shall execute
affidavits,  representations  and  the  like,  from  time  to  time,  at  Landlord's  reasonable request
concerning  Tenant's  best  knowledge  and  belief  without  requirement  for  inquiry  or  due
diligence  regarding  the  presence  of  Hazardous  Materials  on  the  Premises.  In  all  events,
Tenant  shall  indemnify  and  save  Landlord  harmless  from  any  release  or  the  presence  or
existence  of  Hazardous  Materials  on 
the
Commencement Date while Tenant is in possession, or elsewhere on the Property if caused by
Tenant, its employees,  agents  or  contractors. The  covenants  and  indemnity  set  forth  in  this
Section  14.24  shall  survive  the  expiration  or  earlier  termination  of  the  Term  of  this  Lease.
Landlord expressly reserves the right to enter the Premises during Tenant's business hours and
after reasonable prior notice (of not less than three (3) Business Days) to Tenant to perform
regular  inspections  and  testing  with  respect  to  the  presence,  existence,  release  or threat  of
release of Hazardous Materials, provided Landlord shall use reasonable efforts to minimize
disturbance to Tenant’s Permitted Use.

the  Premises  occurring  from  and  after 

14.25 RIGHT OF FIRST OFFER. Provided (a) Tenant is not in Default under this Lease beyond
expiration  of  applicable  notice  and  cure  period;  (b)  Tenant  originally  named  herein  (or  a
related entity or any assignee, sublessee or transferee under a Permitted Transfer or to whom
Landlord  otherwise  consents)  continues  to  occupy  and  operate  all  or  substantially  all  of  the
Premises; (c) subject to the existing rights of other tenant leases, renewals (whether by option or
not),  extensions,  options  to  lease,  or  any  rights  of  first  notice  or  first  offer  to  lease  granted
pursuant to those certain leases and/or occupancy agreements between Landlord and any other
tenants or occupants of the  Building executed prior to the Effective Date, Tenant shall have a
right  of  first  offer  on  the  following  defined  suites  in  their  current  rentable  square  foot
configuration on the second (2nd) and third (3rd) floors of the Building being Suite 200 (10,039
rsf),  Suite  310  (4,247  rsf),  Suite  330  (7,227  rsf),  and  Suite  350  (2,778  rsf)  (collectively
“Specific Suites”), as such suits become Available (as herein after defined) during the term of
this Lease or any extension thereof. At any time during the Term of this Lease, so long as at
least twenty-four (24)  months  of  the  then  term  of  the  Lease  remains  (which  may include an
executed extension period), the procedure for Tenant affecting the right of first offer shall be
exercised in the following manner:
(i) Within  one  hundred  and  sixty  (60)  days  of  any  Specific  Suites  becoming  Available,
Landlord  shall  give  written  notice  (email  being  sufficient  to  Tenant’s  President  or  legal
counsel)  describing  to  Tenant  the  Availability  of  or  the  projected  Availability  of  any
Specific Suites subject to the terms described herein (“Availability Notice”). “Available”

or  “Availability”  shall  mean  that  any  Specific  Suites,  is  not  subject  to  a  lease  and  (a)  is
vacant; or (b) Landlord has received written notice of termination or non-renewal, whether
by renewal option or not, and will become free of leasehold commitment within the six
(6) month period and thereafter obtains actual and legal possession of said Specific Suites
free and clear of all claims, interests (except for Building tenants that have superior rights),
tenants,  and  debris,  and  Landlord  is  free,  and  has  elected  to  lease  space  to  third  parties
without restriction. The prsf basic rent for any Available Specific Suites shall be the same as
the then current prsf basic rent for the Premises, and shall increase at the same rate and on
the same change dates; and

(ii) Tenant  shall  have  fifteen  (15)  days  to  exercise  its  right  of  first  offer  by  written  notice
(email being sufficient to Robert L. Duffy, Jr.) to Landlord to accept or reject Landlord’s
Availability Notice for any Specific Suites offered; and

(iii)Except  as  otherwise  provided  herein,  any  Specific  Suites  shall  be  delivered  in  “as-is”
condition,  and  shall  become  part  of  the  Premises  hereunder  upon  the  delivery  of  any
Specific Suites to Tenant and Landlord shall have no obligation to complete any work or
provide  any  allowance  to  prepare  any  Specific  Suites  for  Tenant’s  occupancy.  Following
such  election  by  Tenant,  and  effective  as  of  the  date  the  Tenant  takes  possession  of  any
Specific  Suites  and  for  the  balance  of  the  then  term  of  the  Lease,  and  any  extension
thereof: (a) the “Premises”, as used in this Lease, shall include any Specific Suites; (b) the
“Premises Rentable Area” shall be increased to include the rentable square footage of  any
Specific Suites taken by Tenant; and (c) the basic annual rent shall equal the sum of the
basic rent for the Premises provided for in this Lease plus any Specific Suites basic rent;
the  Parties  shall  within  thirty  (30)  days  of  Tenant’s  written  response,  execute  a  lease
agreement  or  lease  modification  to  reflect  any  Specific  Suites  taken  by  Tenant,  the
adjusted terms of the Lease, if any, and such other changes as may be required to reflect
the addition of any Specific Suites; and

(iv) In  the  event  Tenant  does  not  accept  any  Specific  Suites  detailed  in  the  Landlord’s
Availability  Notice  within  the  fifteen  (15)  day  period  outlined  above,  or  in  the  event  the
parties  are  unable  to  conclude  a  lease  agreement  or  modification  for  any  Specific  Suites
within  the  above  thirty  (30)  day  period,  the  Tenant  shall  be  deemed  to  have  refused  the
particular Specific Suites detailed in the Availability Notice and Landlord may offer and
contract for lease such Specific Suites to third parties, and the Tenant’s right of first  offer
under this Section 14.25 of the Lease shall lapse and be of no further force or effect, until
such  time  as  the  Landlord  has  leased  the  Specific  Suite(s)  detailed  in  the  Landlord’s
Availability  Notice  to  a  third  party  and  such  Specific  Suite(s)  thereafter  becomes
Available; and

(v) The  terms  of  this  right  of  first  offer  are  not  applicable  if  any  Specific  Suites  becomes
Available pursuant to another tenant’s default or sublease clause (unless and until Landlord
obtains actual and legal possession thereof); or if any Specific Suites may be subject to a
new  lease,  renewal  (whether  by  option  or  not),  extension  or  amendment  by  the  current
occupant  or  successor  in  interest  thereto;  or  any  Specific  Suites  which  is

subject to a fully executed proposal for rental terms with a third party which predates the
Commencement Date.

14.26 OPTION TO EXTEND THE TERM. Provided no Tenant Default has occurred; the Premises
has not been reduced by more than fifty (50%) percent; the Premises (as constituted at lease
execution) has not been sublet or assigned except pursuant to a Permitted Transfer or with the
consent  of  Landlord;  and  Tenant  continues  to  occupy  the  entire  Premises  (but  excluding
subleased premises under a Permitted Transfer);; then Tenant shall have one (1) five (5) year
option to extend the Lease Term at a rent equal to the market rate for equivalent office space in
similarly  located  buildings  within  the  Waltham  market.  Tenant  must  give  Landlord  written
notice it is exercising its extension option no later than nine (9) months prior to the expiration of
the  then  current  Lease  Term  (“Extension  Notice”).  Landlord  shall  provide  Tenant  with
Landlord  reasonable  estimate  of  the  basic  rent  rate  for  the  extended  Term  within  thirty  (30)
days  of  receiving  the  Extension  Notice,  which  estimate  shall  reflect  Landlord’s  good  faith
determination  of  then  applicable  market  rate  rent.  If  Tenant  does  not  object  to  Landlord’s
determination of the basic rent for the extension term by written notice to Landlord within ten
(10) days after receipt of Landlord’s notice of Landlord’s determination of market rate basic
rent, then Tenant shall be deemed to have accepted basic rent as set forth in Landlord’s notice. If
Tenant does timely object within said ten (10) day period to Landlord’s determination, then the
parties  shall  use  commercially  reasonable  efforts  to  agree  upon  the  basic  rent  for  such
extension term; provided however, if the parties cannot agree upon basic rent for the extension
term  within  ten  (10)  days  after  Landlord  receives  Tenant’s  objection  (the  "FMR  Resolution
Period"),  then  the  Parties  shall  proceed  as  provided  in  Exhibit  G  attached  hereto  and
incorporated  herein  by  reference.  Tenant  shall  be  responsible  for  all  payments  necessary  to
maintain a security deposit equivalent to a minimum of two (2) month’s Basic Rent.  Unless
provided  otherwise  by  Landlord,  all  other  terms  and  provisions  under  the  Lease,  other  than
Landlord’s  Work,  other  tenant  improvements,  any  rent  deferral  or  abatement,  or  any  other
terms the Landlord and Tenant agree to mutually amend, shall continue through  the  extended
Lease Term. In  the  event  the  Tenant  does  not  provide  the  Extension  Notice,  execute  a  lease
amendment  and  provide  payment  as  provided  herein,  the  Tenant  shall  be  deemed  to  have
waived its option to extend the Lease Term and this Lease shall terminate upon the expiration of
the then current Term.

14.27 EARLY ACCESS. Provided no event of Tenant Default has occurred and the Tenant does not
interfere with the rights of other tenants or the Landlord’s Work, Tenant and Tenant’s vendors
will  be  allowed,  upon  reasonable  Tenant  notice  and  approval  of  the  Landlord,  reasonable
access to the Premises fifteen (15) days prior to the Commencement Date to permit Tenant  to
install telephone and data cabling, security systems, modular furniture, fixtures, furniture, and
equipment  to  allow  for  a  transition  into  the  Premises.  During  such  access,  Tenant  shall  be
bound by all of the obligations of the Tenant under the Lease, including any and all insurance
requirements, but, provided that said access is solely for the purposes listed

above  to  allow  for  a  transition  into  the  Premises,  excluding  the  payment  of  Base  Rent  and
Tenant’s  proportionate  share  of  Real  Estate  Taxes  and  Operating  Expense  during  the  above
referenced early access period and without obligation for payment of utilities or other charges.
14.28 FINANCIAL  STATEMENTS.  Within  ten  (10)  days  after  Landlord  has  made  a  written
request, Tenant agrees to deliver to Landlord a complete financial statement certified by an
independent certified public accounting firm, g firm, provided such request shall not be made
more  than  once  in  any  twelve  (12)  month  period  and  all  information  received  shall  be
maintained  in  confidence  and  shall  not  be  disclosed  to  third  parties  except  Landlord’s
lenders,  investors,  accountants  and  legal  advisors,  and,  in  each  such  case,  subject  to
reasonable confidentiality requirements.

14.29 GOVERNING LAW. This Lease shall be governed exclusively by the provisions hereof and

by the laws of the Commonwealth of Massachusetts.

14.30 TIME OF THE ESSENCE. Landlord and Tenant each agree that time is of the essence to

each and every term and provision of this Lease.

14.31 AUTHORITY FOR EXECUTION. The  person  executing  this  Lease  on  behalf  of  Tenant
hereby covenants and warrants that he or she was duly authorized to so execute this Lease
and that this Lease is the valid and binding obligation of Tenant.

14.32 FORCE MAJEURE.  It is understood and agreed that in any case where Tenant is required to
do  any  act  (other  than  the  payment  of  money  due  under  this  Lease),  delays  caused  by  or
resulting from an Act of God, war, civil commotion, fire or other casualty,  labor difficulties,
shortages of labor, materials or equipment, governmental regulations or orders, pandemic or
other causes beyond Tenant’s reasonable control shall not be counted in determining the time
when  the performance of such act  must  be completed, whether such time be  designated by
fixed time, a fixed period of time or a “reasonable time.”

[SIGNATURE PAGE TO FOLLOW]

IN WITNESS WHEREOF, Landlord and Tenant have caused this Lease to be duly
executed,  under  seal,  by  persons  hereunto  duly  authorized,  in  multiple  copies,  each  to  be
considered an original hereof, as of the date first set forth above.

LANDLORD
Prospect Fifth Ave, LLC

/s/ Robert L. Duffy
By: Robert L. Duffy, Jr., Manager
Duly Authorized

TENANT
Ardelyx, Inc.

/s/ Mike Raab
By: Mike Raab, CEO
Duly Authorized

EXHIBIT A

PLAN
Suite 210

Plan as of 12/21/2020

Suite 210
Glass and Furniture Plan

Plan as 12/22/2020

Glass walls and doors marked on this Plan are highlighted in yellow and marked with letter x. Glass

installation shall be a part of the work performed by Creative, at the Tenant’s sole cost and
expense. The glass and furniture are shown for informational and illustrative purposes only,
and not included in the Landlord’s Work.

Suite 300

Plan as of 12/15/2020

EXHIBIT B
Landlord’s Work

Landlord  shall  conduct  the  following  Landlord’s  Work  using  available  building  standard  quantities
and  materials  per  the  Building  Standard  attached  hereto  as  Exhibit  B-1,  at  the  Landlord’s  sole  cost
and  expense,  building  per  the  mutually  approved  Plan  attached  hereto  as  Exhibit  A,  including  the
following:

Suite 210

Single and shared offices, as shown and defined by size on the Plan;

-
- Office walls shall go above ceiling tile grids, and CEO’s office and conference room(s) walls

shall go to the deck;

- Three (3) electrical outlets in standard office;
- Offices to be carpeted, kitchen to be V.C.T;
- Direct/indirect lighting fixtures;
- Approximately one (1) light per 100 square feet in each office;
- Conference rooms, as shown on the Plan;
- New paint and carpet, per Building Standard;
- Kitchen cabinets p-Lam, and hard surface countertops (all appliances on Tenant to provide, at

its sole cost and expense);

- Deliver the premises with all HVAC/heating systems in good working order; and
- Costs associated with architectural/engineering expenses.

Tenant  shall  be  solely  responsible,  at  its  sole  cost  and  expense,  for any  of  the  following  (as
applicable):

1. Special engineering/design fees beyond those required for a building permit;
2. All costs associated with branding the space or logo work (Suites 210 and 300);
3. Extraordinary or specialty lighting and controls in the open ceiling area
4. Furniture, fixtures, and equipment;
5. The standard lease exceptions to the Landlord’s Work listed below.

Paint and carpet, similar to Suite 210; and

-
- Kitchenette.
- Otherwise, in “AS-Is, Where-Is Condition”.

Suite 300

Not included in the Landlord’s Work are any and all costs or work associated with:

(i) telephone/data/voice/network throughout the Premises; and
(ii) cubicles and/or open areas, including but not limited to costs or work associated with their
purchase,  installation  or  setup,  and  any  telephone/data/voice/network  and/or  A/C  power
wiring, coring, through floor access modules, or other wiring therefore; and
(iii) Interior  blinds;  the  installation  of  any  interior  blinds  and/or  window  treatments  which
may  be  visible  from  the  common  area  or  outside  the  Premises  is  subject  to  the  Landlord’s
written consent;
(iv) Coring the conference room floor(s) and/or the server room(s), if any (Landlord’s Work
shall include coring if required by applicable law); and
(v) Any furniture or appliances.

Except for the items noted above and subject to the requirements of Section 4.2 and Section 4.3 of

this  Lease,  the  Premises  shall  be  delivered  in  “AS  IS”  condition  and  Tenant  acknowledges  that  by
accepting possession of the Premises, the Premises “AS IS” are suitable for its intended use subject to
Landlord’s satisfactory completion of all punchlist items. Tenant agrees that Landlord may make any
immaterial  changes  to  the  Landlord’s  Work  listed  above,  if  any,  which  may  become  reasonably
necessary or advisable, without the approval of the Tenant; and Tenant may make material changes in
such Landlord’s Work but only with the prior approval of Tenant or it required by any applicable law
or regulation.

Tenant  shall  be  solely  responsible  for  all  costs  and  expenses  resulting  from  requests  by  Tenant  for
work,  quantities  or  materials  in  excess  of  the  Building  Standards,  Landlord’s  Work  noted  above  or
otherwise  by  this  Lease  or  as  a  result  of  Tenant  Delays  (as  herein  defined).  “Tenant  Delays”  shall
mean  delays  caused  by:  (a)  requirements  of  the  plans  requested  by  Tenant  that  do  not  conform  to
Landlord’s Building Standards for office build-out; (b) any change in the plans requested by Tenant;
(c) failure  to  approve  the  plans  (or  changes  thereto  or  modifications  thereof)  within  the  time  limits
provided  by  Landlord’s  construction  representative;  (d)  any  request  by  Tenant  for  a  delay  in  the
commencement  or  completion  of  Landlord’s  Work  for  any  reason  other  than  due  to  Force  Majeure
Event once such work has commenced; or (e) any other act or omission of Tenant or its employees,
agents or contractors. Tenant understands and agrees that changes to the Landlord’s Work/Plan(s) that
may be  needed  or  desired  by Tenant  after  the  execution  of  this  Lease,  and  or  the  specification  by
Tenant of any components or finishes that are not building-standard or as depicted on the Plan(s), will
be incorporated into the Plan(s), only if (i) such changes do not modify the  scope  or  character  of the
Landlord’s Work or any material component thereof, and (ii) such changes will not, individually or in
the aggregate, in Landlord’s reasonable opinion, result in a delay in the substantial completion of the
Landlord’s Work (after taking into account any time savings achieved thereby). Tenant agrees that any
additional  cost  resulting  from  such  changes,  as  well  as  from  any  changes  to  the  Landlord’s  Work
(including  design  and  construction  costs,  including  materials,  labor  and  general  conditions  costs),
after taking into account any cost savings achieved thereby, shall be the responsibility of Tenant and
shall be paid in full b Tenant to Landlord within thirty (30) days of billing therefor by Landlord; and
Tenant agrees that if such changes do result in delay in substantial completion, same shall be deemed
a Tenant Delay and the Commencement Date shall be deemed to be the date Landlord’s Work would
have  been  completed,  if  not  for  the  Tenant’s  change  requests  to  the Landlord’s  Work/Plan(s),  as
reasonably  determined  by  Landlord.  Notwithstanding  the  foregoing,  no Tenant  delay as  used  herein
shall  exist  unless notice  thereof  is  provided  to  Tenant  and  Tenant  fails  to rectify  the  cause  thereof
within seven (7) days of such notice.

The  date  of  Substantial  Completion  shall  be  the  date  Landlord’s  Work  is  substantially  complete  as
defined  in  Section  4.3  of  this  Lease.  Tenant  opening  for  business  in  the  Premises  shall  be  deemed
conclusive  evidence  of  the  Substantial  Completion  of  the  Landlord’s  Work.  Notwithstanding  the
foregoing, if any delay in the Substantial Completion of the Landlord’s Work is due to Tenant Delays,
then  the  Substantial  Completion  Date  shall  be  deemed  to  be  the  date  Landlord’s  Work  would  have
been substantially completed, if not for same, as reasonably determined by Landlord.

Flooring:

Paint:

Electrical:

Hardware:

Doors:

Acoustical:

EXHIBIT B-1
BUILDING STANDARDS

Carpet, commercial grade, 26 - 28 oz. glue down or carpet tile, (Shaw Contract or equal) Vinyl
base, 4” commercial (with/without toe) VPI or equal. V.C.T., where specified or required to be
Armstrong standard Exelon or equal, color by Tenant.

Walls, Benjamin Moore Aqua Regal or equal One coat primer tinted
One coat finish, color by Tenant.

Door frames, two coats Benjamin Moore Satin Impervo
Color by Tenant

Every room shall have a light switch or occupancy sensor as required.  Every office wall shall
typically have one duplex electrical outlet on each wall.  Floor outlets if required by code.  All
tel/data by tenant.

Schlage “A” series – nickel lever Butts, 1 ½ pair per leaf
All hardware Schlage unless noted otherwise
Locksets or Store Room function provided for offices and other secure areas.  Passage
sets on all others.

3’  x 7’  Birch  or  Maple  veneer  with  hollow metal frames,  with separate  24”  – 30”
sidelights per tenant requirement at select locations.

Armstrong  Prelude  grid  15/16”,  2’  x  2’  Mars  Clima  Plus  Acoustical  Ceiling  Tile.
Generally at 9’ AFF

Lighting:

2’ x 4’ Avanti direct/indirect, approximately 1/100 square feet.  LED

HVAC:

Partitions:

All  zones,  water  source  heat  pumps.  Cooling  capacity,  approximately  2.5  –  3.0
tons/1,000 sf.

Office, 2” x 4” 25gauge metal studs @ 16” o.c. insulated for sound attenuation at select
locations.  Typically 9’6” – 10’ high.
Tenant demising, 2” x 4” 25 gauge metal studs @ 16” o.c. to underside of deck with
sound attenuation

Tenant Entry:

Single or pair of 3/0 x 7/0 glass doors with magnetic locks to be connected to Ardelyx system.

Tenant Interior
Signage:

Building standard signage on lobby directory and at entry to suite.

Loading Docks:

One (1) public building dock (standard 48” tailgate height)

Exterior Window
Treatments:

Vertical blinds as presently exist.

EXHIBIT C BUILDING
SERVICES

1.

Heating  and  Cooling.  Landlord  shall  supply,  on  Business  Days  as  defined  in  Section  1.3,
from 8:00 a.m. to 6:00 p.m. heating and cooling as normal seasonal changes may require to
provide  reasonably  comfortable  space  temperature  and  ventilation  for  occupants  of  the
Premises under normal business operation at an occupancy of not more than one person per
150 square feet of Premises Rentable Area and an electrical load not exceeding 3.0 watts
per square foot of Premises Rentable Area. If Tenant shall require air conditioning, heating or
ventilation outside the hours and days above specified, Landlord shall furnish such service
and Tenant shall pay therefor such charges as may from time to time be in effect. The rate in
effect  as  of  the  date  of  this  Lease  shall  be  $7.50  per  ton  per  hour,  and  shall  be  subject to
increase or decrease thereafter to reflect increases or decreases thereafter in utility rates. In the
event  Tenant  introduces  into  the  Premises  personnel  or  equipment  which  overloads  the
capacity of the Building system, or in any other way interferes with the system’s ability to
perform  adequately  its  proper  functions,  or  is  requested  by  Tenant,  if  and  as  needed,  at
Landlord’s  option  or  Tenant’s  election,  the  Landlord  shall  provide  the  supplementary
systems, at Tenant’s expense. The maintenance, repair, replacement, and expense to operate
any supplementary systems during the term of the Lease, or any extension thereof, shall be
the sole obligation of the Tenant.

2.

Cleaning Schedule:

NIGHTLY: Between the hours of 5:00 p.m. and 6:00 a.m., Monday through Friday, legal
holidays excluded.

1. Restrooms:
● Dust and spot clean all toilet partitions, tile walls and receptacles.
● Refill all dispensers including soap, toilet tissue, paper towels, etc.
● Dust mop or sweep floors thoroughly; wash and rinse using a germicidal detergent.
● Empty all trash receptacles and replace plastic liners.
● Clean and polish all chrome fittings and bright work, including shelves, flushometers and

metal dispensers.

● Clean, sanitize and polish all fixtures including toilet bowls, urinals and sinks using a

germicidal detergent solution.

● Clean and sanitize both sides of toilet seats with a germicidal detergent solution.
● Clean and polish all mirrors and glass.

2. Wash and clean water fountains with a germicidal detergent solution.
3. Office rubbish removal. Empty  wastebaskets  and  replace  liners,  resulting  from  business
office use, not including manufacturing or product packaging materials,  the  removal  and
disposal of this type of rubbish is Tenants responsibility.

4. Vacuum carpeted areas as needed.
5. Dry mop, wet mop and burnish tile floors to a polished appearance and/or vacuum and spot

clean carpeting.

6. Wet wipe tabletops in employee lounge, including cleaning of any spills, if applicable.
7. Keep sidewalks and parking area clean and rubbish free.
8. Clean entrance door glass to remove finger marks, smudges, etc.

WEEKLY:

1. Dust rails and sills or as needed.
2. Sweep stairwells and landings or as needed.
3. Edge vacuum and moldings.
4. Keep lawn and landscaping properly maintained, if applicable.

QUARTERLY:

1.  HVAC filters cleaning and/or changing filters on roof tops and air handlers. (Lab

areas and specialized sections not included)

ANNUALLY:

1.  Wash all windows inside and out.

*Note: Lab areas and specialized sections are not included in the above-mentioned cleaning
schedule and are the sole responsibility of the Tenant.

COVID-19 Considerations:
Landlord  shall  be  responsible  for  standard  office  janitorial  and  office  rubbish  removal  inside  of  the
Premises, including compliance with federal, state and local COVID-19 requirements then in effect, as
may be amended or terminated in the future, while the cleaners are within the Premises performing such
standard  janitorial  services  and  office  rubbish  removal  (i.e.  cleaners  will  be  wearing  a  face  mask).
Tenant  shall  separately  contract  with  the  Landlord’s  cleaning  provider  for  any  cleaning  services in
excess of the Landlord’s  standard  office  cleaning  within  the  Premises,  as  the  Tenant  elects to  have
performed or is otherwise required by federal, state, and local COVID-19 related requirements and laws.
Landlord  will  be  responsible  for  compliance  with  COVID-19  heightened  cleaning  and  signage
pursuant to federal, state, and local requirements throughout the interior common areas of the Building,
including  proper  signage  at  the  entry  doors  and  elevators,  and  enhanced  cleaning  of  high  touch
interior  common  area  surfaces.  Compliance  and  enforcement  of  COVID-19  federal,  state,  and local
requirements  and  laws,  including  but  not  limited  such  things  as  social  distancing,  compliance  with
signage, and the wearing of a face masks shall be  the  responsibility  of  the  applicable  governmental
authority.  Tenant  shall  be  responsible  for  supplying  face  makes,  hand  sanitizer,  and  other  PPE  for
Tenant’s  personnel,  promulgating  and  enforcing  company  policies  related  to  compliance  with
COVID-19 federal, state,  and  local  requirements  and  laws.  Landlord  may  amend  or discontinue any
heightened cleaning, additional signage, or any other services/notifications mandated by federal, state,
and local COVID-19 requirements and laws, as and when such federal, state, and local requirements
and laws are amended, expire, or are otherwise no longer applicable.

Security Measures:

The Tenant will be entitled to provide, maintain, replace, remove, and install its own security system
within the Premises during the Term, at its sole cost and expense; to install, in a workmanlike fashion,
system components of the Tenant’s choosing that include key systems (keyways & cylinder), security
cameras and card readers (which may be mounted immediately outside the Premises in the common
areas accessible from the Premises). Landlord shall endeavor to timely review and approve requests
made by Tenant for the installation and use of additional security measures and equipment within the
Premises  and  adjacent  common  areas  of  the  Building  as  of  and  after  the  execution  of  the  Lease.

Landlord’s  review  and  approval  of  such  security  measures  and  equipment  shall  be  in  its  sole
discretion, which shall include but is not limited to how such security measures and equipment may
integrate  into  the  Building’s  security  systems,  privacy  rights  of  other  tenants  or  visitors  of  the
Building, and how Landlord, its agents or employees, or emergency responders will gain access to the
Premises in the case of an emergency.

3.

Electrical Service.
A.

Landlord shall supply electricity to the Premises to meet a requirement not to
exceed  3.0  watts  per  square  foot  of  Premises  Rentable  Area  for  lighting  and  for  office
machines through standard receptacles for standard single-phase 120 volt alternating current.
Tenant  agrees  in  its  use  of  the  Premises  not  to  exceed  such  requirement  and  that its  total
connected  lighting  load  will  not  exceed  the  maximum  from  time  to  time  permitted under
applicable governmental regulations. Landlord shall purchase and install, at Tenant's expense
(other  than  those  in  place  as  of  the  Commencement  Date),  all  lamps,  tubes,  bulbs, starters
and ballasts. Tenant shall pay all charges for electricity used or consumed in the  Premises
either  directly if  separately/check  metered  or  as  otherwise  calculated  as  a  pro  rata share.
Tenant shall pay the cost of any electric meter to be used or installed in the Premises unless
included in Landlord’s Work, and keep such meter in good operating condition. In order to
assure that the foregoing requirements are not exceeded and to avert any possible adverse
effect on the Building's electric system, Tenant  shall not, without  Landlord's prior written
consent, which consent shall not be unreasonably withheld or delayed, connect any fixtures,
appliances  or  equipment  to  the  Building's  electric  distribution  system  other  than
typewriters,  pencil  sharpener,  adding  machines,  handheld  or  desk  top  calculators,
dictaphones,  clocks,  personal  computers  and  radios  and  other  customary  general  office
machinery and equipment. The Tenant Electrical Rate of $1.75 prsf per annum is subject to
review  and  adjustment  by  Landlord  as  hereinafter  provided  ("Tenant’s Electrical  Charge"),
provided  no  adjustment  or  change  therein  shall  be  made  prior  to  the  second  (2nd)
anniversary of the Effective Date, and thereafter such adjustment or change shall be only be
commiserate  with  the  direct  increase  in  the  cost  of  supply  thereof  by  the  utility provider.
Landlord shall provide written notice to the Tenant thirty (30) days prior to the effective date
of any increase in the Tenant Electrical Rate.

B.

If  applicable,  Tenant  shall  pay  the  Tenant's  Electrical  Charge  for  such
service.  Except  as  herein  specifically  set  forth,  the  Tenant's  Electrical  Charge  shall  be
unaffected by the extent of use of such service by Tenant and is deemed to be included as
rental  under  this  Lease  payable  as  and  when  provided  in  Section  3.1  of  this  Lease.  If
Landlord  reasonably  determines,  from  time  to  time,  that  Tenant's  use,  demand  and/or
consumption of electricity exceeds the customary general office usage (any such excess use,
demand  or  consumption  of  electricity  by  Tenant  being  hereinafter  referred  to  as  "Excess
Electricity Use"), Landlord may, at its option, give written notice thereof to Tenant (any such
notice  being  hereinafter  referred  to  as  an  "Excess  Electricity  Notice")  which  notice  shall
specify the amount by which Landlord in good faith estimates that Landlord's cost of such
Excess  Electricity  Use  exceeds  the  cost  had  such  customary  office  usage  been applied
extrapolated as a per rentable square foot charge for the Premises Rentable Area (any such
excess cost being hereinafter referred to as an "Excess Electricity Use Charge"). The Excess
Electricity Use Charge specified in such Excess Electricity Notice shall be due

and payable as additional rent as hereinafter provided. Any Excess Electricity Use Charge
allocable  to  a  period  prior  to  the  date  of  giving  an  Excess  Electricity  Notice  shall,  at  the
option  of  Landlord,  be  payable  as  additional  rent  within  thirty  (30)  days  after  written
demand  is  made  therefor  by  Landlord.  Excess  Electricity  Use  Charges  allocable  to  any
period  after  the  date  of  giving  an  Excess  Electricity  Notice  shall  be  due  and  payable  as
additional  rent  monthly  in  advance  in  equal  monthly  installments  for  the  balance  of  the
Term of this Lease on the first day of each calendar month during the Term of this Lease
with the first such installment being due and payable on the first day of the first full calendar
month following the date of giving any such Excess Electricity Notice, provided, payment
thereof shall cease if and when Tenant’s usage is restored to customary general office usage
(extrapolated as a per rentable square foot charge for the Premises Rentable Area).

C.

If  applicable,  Landlord  will  determine  Excess  Electricity  Use  at  Landlord's
option, as follows: (i) by installing submeter(s) and/or check meter(s) and related wiring and
equipment in the Premises at Landlord's expense and/or (ii) by estimating Excess Electricity
Use  in  the  Premises,  such  estimates  to  be  prepared  by  an  independent  electrical engineer
engaged  by  Landlord  at  Landlord’s  cost  and  expense  and/or  (iii)  by  any  other  reasonably
reliable  method  reasonably  selected  by  Landlord  to  estimate  and/or  calculate  Excess
Electricity Use. Excess Electricity Use Charges shall be established by Landlord based upon
Excess  Electricity  Use  established  as  aforesaid  and  based  upon  Landlord's estimate  of  the
additional cost of such electricity to Landlord over and above the Tenant's Electrical Charge
and  any  than  existing  Excess  Electricity  Use  Charges  in  effect.  The  cost  of  such  electric
submeter(s) once installed as well as the cost of installation repair and replacement of  any
such  additional  electrical  submeter(s)  shall  be  borne  by  Tenant.  Payments  due  Landlord
from Tenant under the terms of this Section shall be deemed to be included within the term
"Escalation  Charges".  Landlord  shall  have  the  right,  at  any  time,  during  the  Term  of  this
Lease  and  as  often  as  it  may  elect  to  determine  whether  Tenant  is  incurring  Excess
Electricity Use and to assess Excess Electricity Use Charges as aforesaid.

D.

If Tenant shall require, demand, use or consume electricity in excess  of  the
quantity, voltage or connected load specified in paragraph 3A of this Exhibit C Tenant shall,
within  thirty  (30)  days  after  demand,  reimburse  Landlord,  for  the  cost  of  such  excess
electricity.  Further,  if  (i)  in  Landlord's  reasonable  judgment,  Landlord's  facilities  are
inadequate for such excess requirements, or (ii) such excess use shall result in an additional
burden  on  the  Building's  utility  systems  or  additional  cost  on  account  thereof,  as  the  case
may  be,  Tenant  shall,  within  thirty  (30)  days  after  demand,  reimburse  Landlord  for  all
additional reasonable out of pocket costs related thereto. Further, if after the Commencement
Date Tenant requires electricity in excess of the quantity, voltage or connected load specified in
paragraph 3A of this Exhibit C, Landlord, upon written request from Tenant, and at the sole
cost and expense of Tenant, will furnish and install such additional wire, conduits, feeders,
switchboards and appurtenances as Landlord may reasonably require to supply such additional
requirements of Tenant (if electricity therefor is then available to Landlord without affecting the
Building  or  Landlord's  plans  therefor);  provided  that  Landlord  shall  have  no  obligation  to
furnish  any  such  excess  electricity   unless  the  same  shall  be  permitted  by

applicable law and insurance regulations and shall not cause or threaten  permanent  damage
or  injury  to  the  Building  or  the  Premises  or  cause  or  create  a  dangerous  or  hazardous
condition  or  entail  excessive  or  unreasonable  alterations  or  repairs  or  interfere  with,  or
disturb other tenants or occupants of, the Building or interfere with Landlord's plans for the
Building.

E.

Landlord reserves the right to curtail, suspend, interrupt and/or stop the supply
of  water,  sewage,  electrical  current,  cleaning,  and  other  services,  and  to  curtail,  suspend,
interrupt and/or stop use of entrances and/or lobbies serving access to the Building, without
thereby  incurring  any  liability  to  Tenant,  when  necessary  by  reason  of  accident  or
emergency,  or  for  repairs,  alterations,  replacements  or  improvements  in  the  reasonable
judgment  of  Landlord  are  desirable  or  necessary,  or  when  prevented  from  supplying  such
services or use by strikes, lockouts, difficulty of obtaining materials, accidents or any other
cause beyond  Landlord's  control,  or  by  laws,  orders  or  inability,  by  exercise  of  reasonable
diligence, to obtain electricity, water, gas, steam, coal, oil or other suitable fuel or power. No
diminution  or  abatement  of  rent  or  other  compensation,  nor  any  direct  indirect  or
consequential damages shall or will be claimed by Tenant as a result of, nor shall this Lease or
any of the obligations of Tenant be affected or reduced by reason of, any such  interruption,
curtailment,  suspension  or  stoppage  in  the  furnishing  of  the  foregoing  services  or  use,
irrespective of the cause thereof. Failure or omission on the part of Landlord to furnish any of
the  foregoing  services  or  use  shall  not  be  construed  as  an  eviction  of  Tenant,  actual  or
constructive, nor entitle Tenant to  an abatement  of rent, nor to render the Landlord liable in
damages,  nor  release  Tenant  from  prompt  fulfillment  of  any  of  its  covenants  under  this
Lease. Notwithstanding the generality of the foregoing, Landlord shall use reasonable efforts
to minimize the period of time in which such utilities and services are curtailed, suspended,
interrupted, or stopped.

4.

Other Services.
Landlord shall also provide throughout the Term (as the same may be extended):

A.

Passenger  elevator  service  from  the  existing  passenger  elevator  system  in

common with Landlord and other tenants in the Building.

B.

Hot water for lavatory purposes and cold water (at temperatures supplied by
the municipality in which the Property is located) for drinking, lavatory and toilet purposes.
If Tenant uses water for any purpose other than for ordinary lavatory, hygiene and drinking
purposes,  Landlord  may  assess  a  reasonable  charge  for  the  additional  water  so  used,  or
install a water meter and thereby measure Tenant's water consumption for all purposes. In
the latter event, Tenant shall pay the reasonable out of pocket cost of the meter and the cost of
installation thereof  and  shall  keep  such  meter  and  installation  equipment  in good working
order and repair. Tenant agrees to pay for water consumed, as shown on such meter, together
with the sewer charge based on such meter charges, as and when bills are rendered, and if
Tenant defaults in making such payment, Landlord may pay such charges and collect same
from  Tenant  as  an  additional  charge.  The  foregoing  payment  obligations are  intended  to
result  in  Tenant  paying  the  difference  between  customary  usage  and  extraordinary usage
only.

C.

Free  access  to  the  Premises  on  Business  Days  from  8:00a.m.  to  5:30p.m.,

subject to restrictions based on emergency conditions and restricted access at all other times

under  conditions  imposed  to  provide  security  for  the  Building,  and  all  other  applicable
provisions of this Lease including, without limitation, the provisions of Section 7.4  hereof,
provided  Tenant  shall,  subject  to  the  terms  of  this  Lease,  have  access  to  and  use  of  the
Premises for the Permitted  Use  twenty  four  (24)  hours  per  day,  seven  (7)  days per week,
and three hundred sixty five (365) days per year.

D.

Maintenance of the exterior of the Building, landscaping and lawn care and

ice and snow removal from exterior steps, walkways, parking areas and driveways.

E.

Landlord shall provide for the operation of a cafeteria food service facility or
other type food service (the “Cafeteria”) in the Building.  The Cafeteria will be available for
use by Tenant and its employees, together with others, during its hours of operation and in
accordance  with  any  generally  applicable  and  enforced  rules  and  regulations  that  may  be
established  concerning  such  use.  Charges  for  food  and  other  services  provided  at  the
Cafeteria  shall  be  as  determined  by  Landlord  (or  the  operator  of  the  Cafeteria  or  food
vendor) from time to time in its sole discretion. It is understood and agreed that all use of
the  Cafeteria  and  its  facilities,  or  food  vendor  shall  be  at  the  sole  risk  of  Tenant  and  the
employees using same, and, to the maximum extent this agreement may be made  effective
according to law (including the limitations set forth in M.G.L. c. 186, §15), but subject to
Tenant’s  insurance  requirements  hereunder  and  Section  13.22,  Tenant  hereby  releases
Landlord, and the owner or operator of the Cafeteria for food vendor, from any liability in
connection  with  such  use  and  indemnifies  and  holds  the  Landlord,  and  the  owner  or
operator of the Cafeteria or food vendor, harmless from and against any loss, cost, liability,
damage or expense occasioned by or in any way related to or arising from the use of the
Cafeteria by Tenant  or  Tenant’s  employees  or  by  any  other  party  allowed  to  use same by
Tenant  or  any  of  its  employees.  There  is  expressly  excluded  from  the  foregoing
indemnification, hold harmless agreement and waiver any loss, cost, liability, damage and
expense  arising  from  the  gross  negligence  or  willful  misconduct  of  Landlord  or  its
employees, contractors, agents or invitees. Landlord reserves the right at any time or from
time to time, in its sole discretion, to alter the size, type, location or serving capacity of the
Cafeteria  or  food  vendor,  or  its  meals  or  hours  of  operation  or  any  other  aspect  thereof,
provided however Landlord shall provide for some kind of food service on Business Days
(Landlord reserves the right to not provide food service on Business Days that are the day
before  or  after  the  holidays  listed  in  the  definition  of  Business  Days)  within  or  about  the
Building  and  as  described  below.  Notwithstanding  the  forgoing  and  due  to  the  Force
Majeure Event associated with COVID-19, the Cafeteria and other type food service are not
currently operating or being offered in or about the Building and shall not be offered until
the  Force  Majeure  Event  has  ended.  Further,  the  Landlord  reserves  the  right  to  keep  the
Cafeteria closed and not offer any type food service for six (6) months past the end of the
present  Force  Majeure  Event  ending,  as  it  may  not  be  economically  viable  to  operate.
Thereafter and in the discretion of the Landlord, food service to the Building on Business
Days may be the standard Cafeteria service or Avanti Micro Market or similar/better type
service, and may be supplemented on certain Busines Days with third party food providers,
food  trucks,  or  similar.  To  the  extent  the  Cafeteria  is  open  or  food  service  is  being  made
available to the Tenant as provided herein, Tenant shall pay to Landlord, as additional  rent
and on a so-called net basis, Tenant’s share (as computed in Article 1) of any losses, costs or
subsidies incurred or paid by Landlord in operating the Cafeteria or other type food service
within thirty (30) days of invoice therefor; provided Landlord may elect to collect

same  in  monthly  estimated  payments  (as  reasonably  estimated  by  Landlord  from  time  to
time), due on the same date as monthly Basic Rent installment payments are due hereunder,
with a periodic (not more often than annual) reconciliation

F.

Landlord  shall  open,  operate,  and  make  available  to  Tenant,  at  least  on
Business Days, a fitness center facility (the “Fitness Center”) in the Building. The Fitness
Center shall available for use by Tenant and its employees, together with others, during  its
hours of operation and in accordance with any rules and regulations that may be established
concerning  such  use,  including  compliance  with  COVID-19  regulations  regarding  gyms.
Charges  for  use  of  and  services  provided  at  the  Fitness  Center  shall  be  as  determined  by
Landlord (or the operator of the Fitness Center, as the case may be) from time to time in its
sole  discretion.  It  is  understood  and  agreed  that  all  use  of  the  Fitness  Center  and  its
facilities  shall  be  at  the  sole  risk  of  Tenant  and  the  employees  using  same,  and,  to  the
maximum  extent  this  agreement  may  be  made  effective  according  to  law  (including  the
limitations set forth in M.G.L. c. 186, §15), but subject to Tenant’s insurance requirements
hereunder,  Tenant  hereby  releases  Landlord,  and  the  owner  or  operator  of  the  Fitness
Center,  from  any  liability  in  connection  with  such  use  and  indemnifies  and  holds  the
Landlord, and the owner or operator of the Fitness Center, harmless from and against any
loss,  cost,  liability,  damage  or  expense  occasioned  by  or  in  any  way  related  to  or  arising
from  the  use  of  the  in  connection  with  such  use.  There  is  expressly  excluded  from  the
foregoing indemnification, hold harmless agreement and waiver loss, cost, liability, damage
and  expense  arising  from  the  gross  negligence  or  willful  misconduct  of  Landlord  or  its
employees, contractors, agents or invitees. Landlord reserves the right  at  any time  or from
time to time, in its sole discretion, to limit the access to or use of the Fitness Center, or alter
its size, type, location or serving capacity, or hours of operation or any other aspect thereof.
As  of  the  execution  of  this  Lease,  the  Fitness  Center  is  operating  with  certain  additional
rules  and  regulations  of  use  due  to  the  Force  Majeure  Event  associated  with  COVID-19.
However, Landlord may have to restrict access, partially or completely, to the Fitness Center
as  required  to  do  so  by  any  applicable  government  authority  due  to  the  current  Force
Majeure  Event.  To  the  extent  the  Fitness  Center  is  open  and  available  to  the Tenant  as
provided  herein,  Tenant  shall  pay  to  Landlord,  as  additional  rent  and  on  a  so-  called  net
basis, Tenant’s share (as computed in Article 1) of any losses, costs or subsidies incurred or
paid by Landlord in operating the Fitness Center within thirty (30) days of invoice therefor;
provided Landlord may elect to collect same in monthly estimated payments (as reasonably
estimated  by  Landlord  from  time  to  time),  due  on  the  same  date  as  monthly  Basic  Rent
installment  payments  are  due  hereunder,  with  a  periodic  (not  more often  than  annual)
reconciliation. In the event the Premises is separately metered for any utility, Tenant shall
provide  the  applicable  utility  provider  with  all  information  necessary  for  the  Tenant  to
assume control of the appropriate account or meter on or before the earlier of the following,
regardless of whether or not any base rent is due: (i) the  Lease  Commencement  Date;  (ii)
the date of any early access to the Premises, regardless of whether said access is for Tenant
to (a) conduct its business, (b) conduct or participate in any improvements to the Premises,
(c) install or store any fixtures, furniture, or equipment, or  (d)  prepare  the  Premises  for  the
Tenant’s  occupancy  or  move-in.  Tenant  shall  maintain electrical  service  to  the  Premises
throughout  the  Term  of  the  Lease,  regardless  of  whether Tenant is actually occupying the
space or not. The Premises is separately metered for lights and plugs.

EXHIBIT D
OPERATING EXPENSES

Without limitation, Operating Expenses shall include:

All expenses incurred by Landlord or Landlord's agents which shall be directly related to
1.
employment  of  personnel,  including  amounts  incurred  for  wages,  salaries  and  other  compensation
for  services,  payroll,  social  security,  unemployment  and  similar  taxes,  workman's  compensation
insurance,  disability  benefits,  pensions,  hospitalization,  retirement  plans  and  group  insurance,
uniforms  and  working  clothes  and  the  cleaning  thereof,  and  expenses  imposed  on  Landlord  or
Landlord's agents pursuant to any collective bargaining agreement for the services of employees of
Landlord  or  Landlord's  agents  in  connection  with  the  operation,  repair,  maintenance,  cleaning,
management  and  protection  of  the  Property,  and  its  mechanical  systems  including,  without
limitation, day and night supervisors, property manager, accounts, bookkeepers, janitors, carpenters,
engineers, mechanics, electricians and plumbers and personnel engaged in supervision of any of the
persons mentioned above; provided that, if any such employee is also employed on other property of
Landlord,  such  compensation  shall  be  suitably  prorated  among  the  Property  and  such  other
properties.

The  cost  of  services,  utilities,  materials  and  supplies  furnished  or  used  in  the  operation,
2.
repair,  maintenance,  cleaning,  management  and  protection  of  the  Property,  including  without
limitation fees, if any, imposed upon Landlord or charged to the Property by the state or municipality in
which  the  Property  is  located  on  account  of  the  need  of  the  Property  for  increased  or  augmented
public safety services.

The  cost  of  replacements  for  tools  and  other  similar  equipment  used  in  the  repair,
3.
maintenance,  cleaning  and  protection  of  the  Property,  provided  that,  in  the  case  of  any  such
equipment used jointly on other property of Landlord, such costs shall be suitably prorated among
the Property and such other properties.

A  fee  for  the  management  of  the  Property,  not  to  exceed  five  percent  (5%)  of  the  gross
4.
revenues of the Property, including, without limitation, all rent and other charges paid by tenants in
the  Building,  together  with  the  cost  of  reasonable  legal  and  other  professional  fees  relating  to  the
Property,  but  excluding  such  fees  and  commissions  paid  in  connection  with  services  rendered  for
securing or renewing leases and for matters not related to the normal administration and operation of
the Property.

Premiums for insurance against damage or loss to the Building from such hazards as shall
5.
from time to time be generally required by institutional mortgagees in the Boston area for similar
properties,  including,  but  not  limited  to  insurance  covering  loss  of  rent  attributable  to  any  such
hazards, and public liability insurance.

If,  at  any  time  during  the  term  of  the  Lease,  Landlord  installs  or  makes  an  alteration,
6.
improvement,  repair  or  replacement  which  is  classified  as  a  capital  expenditure  and  anticipates  to
effect a reduction or saving in Operating Expenses, the cost of such expenditure amortized over its

useful life, consistently applied, with interest, shall be included in Operating Expenses.

7.
Property and not paid for directly by tenants or for which tenants or other occupants are obligated.

Costs  for  electricity,  water  and  sewer  use  charges,  and  other  utilities  supplied  to  the

8.
the operation, repair, maintenance, cleaning and protection of the Property.

Amounts paid to independent contractors for services, materials and supplies furnished for

9.
Costs and expenses associated with a Cafeteria and Fitness Center shall be directly
allocated  to  each  tenant  based  upon  each  tenant’s  pro  rata  share.  Should  the  Cafeteria  or  Fitness
Center cease operation, the payment of monies under this Exhibit for the Cafeteria or Fitness Center
costs and expenses shall be prorated to reflect the closing date and thereafter no Cafeteria or Fitness
Center costs and expenses shall be owed unless or until the café/cafeteria or gymnasium commenced
operation.

Notwithstanding  the  foregoing,  there  shall  be  excluded  from  Operating  Expenses  those  identified
below:

1)

2)

3)

4)

5)

6)

7)

8)

9)

leasing commissions, fees and costs, advertising and promotional expenses and other costs
incurred in procuring tenants or in selling the Building or the Site;

legal fees or other expenses incurred in connection with enforcing leases with tenants in the
Building;

costs of renovating or otherwise improving or decorating space for any tenant or other
occupant of the Building or the Site, including Tenant, or relocating any tenant;

financing costs including interest and principal amortization of debts and the costs of
providing the same;

except as otherwise expressly provided above, depreciation;

rental on ground leases or other underlying leases and the costs of providing the same;

wages, bonuses and other compensation of employees above the grade of General Portfolio
Manager and fringe benefits other than insurance plans and tax qualified benefit plans;

any liabilities, costs or expenses associated with or incurred in connection with the removal,
enclosure, encapsulation or other handling of Hazardous Substances and the cost of defending
against claims in regard to the existence or release of Hazardous Substances at the Building or
the Site (except with respect to those costs for which Tenant is otherwise responsible pursuant
to the express terms of this Lease);

costs of any items for which Landlord is or is entitled to be actually paid or reimbursed by
insurance;

10)

increased insurance or Real Estate Taxes assessed specifically to any tenant of the Building

or the Site for which Landlord is entitled to reimbursement from any other tenant;

charges for electricity, water, or other utilities, services or goods and applicable taxes for
which Tenant or any other tenant, occupant, person or other party is obligated to reimburse
Landlord or to pay to third parties;

cost of any HVAC, janitorial or other services provided to tenants on an extra cost basis
after regular business hours;

Intentionally Deleted.

cost of correcting defects in the design, construction or equipment of, or latent defects in, the
Building or the Site;

cost of any work or service performed on an extra cost basis for any tenant in the Building or
the Site to a materially greater extent or in a materially more favorable manner than
furnished generally to the tenants and other occupants;

cost of any work or services performed for any facility other than the Building or Site;

any cost representing an amount paid to a person firm, corporation or other entity related to
Landlord that is in excess of the amount which would have been paid in the absence of such
relationship;

any cost of painting or decorating any interior parts of the Building or the Site other than
common areas, stairwells, and loading docks;

Intentionally Deleted.

cost of initial cleaning and rubbish removal from the Building or the Site to be performed
before final completion of the Building or tenant space;

cost of initial landscaping of the Building or the Site;

Intentionally Deleted.

Intentionally Deleted.

cost of the initial stock of tools and equipment for operation, repair and maintenance of the
Building or the Site;

late fees or charges incurred by Landlord due to late payment of expenses, except to the
extent attributable to Tenant’s actions or inactions;

cost of acquiring, securing cleaning or maintaining sculptures, paintings and other works  of
art;

11)

12)

13)

14)

15)

16)

17)

18)

19)

20)

21)

22)

23)

24)

25)

26)

27)

28)

29)

30)

31)

32)

33)

34)

35)

36)

real estate taxes or taxes on Landlord’s business (such as income, excess profits, franchise,
capital stock, estate, inheritance, etc.);
direct costs or allocable costs (such as real estate taxes) associated with parking operations if
there is a separate charge to Tenant, other than tenants or the public for parking;

charitable or political contributions;

all other items for which another party compensates or pays so that Landlord shall not
recover any item of cost more than once;

any cost associated with operating as an on or off-site management office for the Building,
except to the extent included in the management fee permitted hereby;

Landlord’s general overhead and any other expenses not directly attributable to the
operation and management of the Building and the Site (e.g. the activities of Landlord’s
officers and executives or professional development expenditures), except to the extent
included in the management fee permitted hereby;

costs and expenses incurred in connection with compliance with or contesting or settlement
of any claimed violation of law or requirements of law, except to the extent attributable to
Tenant’s actions or inactions;

costs related to governmental compliance in connection with those parts of the Building or
the Site that Landlord is responsible for maintaining and repairing, except to the extent
attributable to Tenant’s actions or inactions;

costs of complying with to Americans With Disabilities Act as otherwise in effect and
enforceable prior to the Effective Date, whether such costs are classified as capital items or
expenses under generally accepted accounting principles, except to the extent attributable to
Tenant’s actions or inactions;

costs of mitigation or impact fees or subsidies (however characterized), imposed or incurred
prior to the date of the Lease or imposed or incurred solely as a result of another tenant’s or
tenants’ use of the Site or their respective premises; and

37)

costs related to public transportation, transit or vanpools.

EXHIBIT E
RULES AND REGULATIONS

1.
The sidewalk, entry, passages, elevator, and stairways shall not be obstructed by the Tenant
and shall not be used by them for any other purpose than for ingress and egress to and from their
respective premises. Excepted from this restriction is use of these facilities for purpose of moving
furniture and equipment to or from the Premises, which is permitted outside of normal office hours
and on a non-interference basis with respect to other occupants of the Building.

No  awnings or other  projections  shall  be  attached  to  the  outside  walls  or  windows of the
2.
Building  without  the  prior  written  consent  of  Landlord.  No  curtains,  blinds,  shades,  or  screens
shall  be  attached  or  hung  in,  or  used  in  connection  with,  any  window  or  door  of  the  premises
demised to any tenant or occupant, without the prior written consent of Landlord. Such awnings,
projections, curtains, blinds, shades, screens, or other fixtures must be of a quality type, design and
color, and attached in a manner, reasonably approved by Landlord in writing in advance. All non-
building standard curtains, blinds, shades, etc. shall not be visible from either the exterior of  the
building or the interior building common areas.

3.
No  sign,  advertisement,  object,  notice  or  other  lettering  shall  be  exhibited,  inscribed,
painted  or  affixed  on  any  part  of  the  outside  or  inside  of  the  premises  demised  to  any  tenant  or
occupant of the Building without the prior written consent of Landlord. Interior signs on doors and
directory tables, if any, shall be of a size, color and style approved by Landlord in writing and in
advance.

4.
The sashes, sash doors, skylights, windows, and doors that reflect or admit light and air into
the halls, passageways or  other  public  places in the  Building  shall  not  be  covered  or  obstructed,
nor shall any bottles, parcels, or other articles be placed on any window sills.

No show cases or other articles shall be put in front of or affixed to any part of the exterior of

5.
the Building, nor placed in the halls, corridors, vestibules or other parts of the Building.

6.
The water and wash closets and other plumbing fixtures shall not be used for any purposes
other  than  those  for  which  they  were  constructed,  and  no  sweepings,  rubbish,  rags,  or  other
substances shall be thrown therein.

7.
No  tenant  or  occupant  shall  mark,  paint,  drill  into,  or  in  any  way  deface  any  part  of  the
Building  or  the  premises  demised  to  such  tenant  or  occupant.  No  boring,  cutting  or  stringing  of
wires  shall  be  permitted,  except  with  the  prior  written  consent  of  the  Landlord,  and  as  Landlord
may  direct.  No  tenant  or  occupant  shall  install  any  resilient  tile  or  similar  floor  covering  in  the
premises demised to such tenant or occupant except in a manner approved by Landlord in writing
and in advance.

8.

No  bicycles,  vehicles,  dogs  (except  for  seeing  eye  dogs  and  similar  animals)  or  other
animals, birds or pets of any kind shall be brought into or kept in or about the premises demised to
any tenant. Bicycles may be stored in racks, if any, furnished for such purpose by Landlord in  a
common area of the Property. No stove or open flame cooking shall be done or permitted in the

Building  by  any  tenant  without  the  approval  of  Landlord.  No  tenant  shall  cause  or  permit  any
unusual  or  objectionable  odors  to  emanate  from  the  premises  demised  to  such  tenant.  Any  open
flame (candle, space heater, cooktop, etc.) is a fire hazard and is strictly prohibited in the Building.
Nothing included in the Landlord’s Work shall be deemed a prohibited item under this paragraph of
this Lease, nor shall use thereof constitute a violation of this paragraph or this Lease.

Without the prior written consent of Landlord, no space in the Building shall be used for

9.
manufacturing, or for the sale of merchandise, goods or property of any kind at auction.

10. No tenant shall make, or permit to be made, any unseemly or disturbing noises or disturb or
interfere  with  other  tenants  or  occupants  of  the  Building  or  neighboring  buildings  or  premises
whether by the use of any musical instrument, radio, television set or other audio device, unmusical
noise,  whistling,  singing,  or  in  any  other  way.  Nothing  shall  be  thrown  out  of  any  doors  or
windows.

11. Each tenant must, upon the termination of its tenancy, restore to Landlord all keys of stores,
storage areas, offices and toilet rooms, either furnished to, or otherwise procured by, such tenant.

12. All  removals  from  the  Building  or  the  carrying  in  or  out  of  the  Building  or  the  premises
demised to any tenant, of any safes, freight, furniture, or bulky matter of any description must take
place at such time and in such manner as Landlord or its agents may determine, from time to time.
Landlord  reserves  the  right  to  inspect  all  freight  to  be  brought  into  the  Building  and  to  exclude
from  the  Building  all  freight  which  violates  any  of  the  Building  Rules  or  the  provisions  of  such
tenant's lease.

13. Landlord shall have the right to prohibit any advertising by any tenant or occupant this, in
Landlord’s opinion, tends to impair the reputation of the Building or its desirability as a building
for  offices,  and  upon  notice  from  Landlord,  such  tenant  or  occupant  shall  refrain  from  or
discontinue such advertising.

14. Each tenant, before closing and leaving the premises demised to such tenant at any time shall
see  that  all  entrance  doors  are  locked,  lights  are  turned  off,  and  windows  closed.  All  electrical
appliances  including  but  not  limited  to,  computers,  monitors,  printers,  copiers,  etc.,  shall  be
powered off at the close of business daily.

15. No  premises  shall  be  used,  or  permitted  to  be  used,  for  lodging  or  sleeping,  or  for  any
immoral or illegal purpose.

16. There shall not be used in the Building, either by any tenant or occupant or by their agents or
contractors, in the delivery or receipt of merchandise, freight or other matter, any hand trucks  or
other means of conveyance except those equipped with rubber tires, rubber side guards and  such
other safeguards as Landlord may require.

17. Canvassing,  soliciting  and  peddling  in  the  Building  are  prohibited  and  each  tenant  and
occupant shall cooperate in seeking their prevention.

18. No  premises  shall  be  used,  or  permitted  to  be  used,  at  any  time,  without  the  prior  written
approval of Landlord, as a store for the sale or display of goods, wires or merchandise of any kind,
or  as  a  restaurant,  shop,  booth,  bootblack  or  other  stand,  or  for  the  conduct  of  any  business  or
occupation  which  predominantly  involves  direct  patronage  of  the  general  public  in  the  premises
demised to such tenant, or for manufacturing or for other similar purpose.

19. No  tenant  shall  move,  or  permit  to  be  moved,  into  or  out  of  the  Building  or  the  premises
demised to such tenant, any heavy or bulky matter, without the specific approval of Landlord. If
any such matter requires special handling, only a person holding a Master Rigger's license shall be
employed to perform such special handling. No tenant shall place, or permit to be placed, on any
part of the floor or floors of the premises demised to such tenant, a load exceeding the floor load
per square foot which  such  floor  was  designed  to  carry  and  which  is  allowed  by  law.  Landlord
reserves the right to prescribe the weight and position of safes and other heavy matter, this must be
placed  so  as  to  distribute  the  weight.  All  engineering  required  to  verify  installation  method  and
feasibility shall be at tenant's expense.

20. The  requirements  of  tenants  will  be  attended  to  only  upon  application  by  tenant  to  the
landlord in writing. Building employees shall not be required to perform, and shall not be requested
by  any  tenant  or  occupant  to  perform,  any  work  outside  of  their  regular  duties,  unless  under
specific instructions from the office of the managing agent of the Building.

21. Tenant shall restrict parking by Tenant, its employees, service providers, agents, and visitors to
parking  areas  designated  by  Landlord  and  shall  comply  with  reasonable  parking  rules  and
regulations  as  may  be  modified,  posted,  and  distributed  by  Landlord  from  time  to  time.  The
parking  spaces  shall  not  be  used  for  overnight  parking  or  dead  storage  of  vehicles  or  other
merchandise  or  material.  All  vehicles  parked  or  traveling  through  the  common  areas  of  the
Building shall maintain a current registration and be properly insured. All parking shall be within
the striped spaces in the parking lot. Landlord reserves the right to promulgate a system of parking
stickers or passes as necessary to control parking by tenants and their visitors, and tenants shall
reasonably cooperate in the implementation of such system.

22. All locks for doors in each tenant's Premises shall be building standard and no tenant shall
change  or  install  any  additional  lock  or  locks  on  any  door  in  its  leased  area  without  Landlord's
written  consent.  Tenant  shall  provide  Landlord  all  access  codes  and  any  other  devices  necessary
for Landlord's entry to Tenant's premises.

23. All Tenant entry doors, when not in use, shall be kept closed.

24. Landlord will not be responsible for lost or stolen personal property, money or jewelry from
any  premises  demised  to  any  tenant  or  occupant  or  public  areas  regardless  of  whether  such  loss
occurs when the area is locked against entry or not.

25. Tenant  shall  not  duplicate  Access  Keys  or  Access  Control  Cards.  Tenant  shall  promptly
report to Landlord any and all lost or stolen Access Keys or Access Control Cards. Lost or stolen
Access Keys or Access Control Cards will be replaced by Landlord after notification. Replacement
and any associated security system reprogramming shall be at Tenant's sole cost and expense.

26. Every reference herein to “Landlord’s Consent or Approval” means “prior written consent or
approval of the Landlord in each instance”.

27. No Tenant shall smoke tobacco or marijuana in any part of the Property. Upon notice from
the Landlord, Tenant shall immediately cease all activity in and around the Property which, in the
reasonable  discretion  of  the  Landlord,  constitutes  noisy,  offensive  or  disruptive  activity.  Tenant
shall be responsible for the acts and omissions of their employees, agents, invitees and assigns.

28. No  Tenant  shall  use  any  method  of  heating  or  cooling  other  than  that  provided  by  the
Landlord, without the Landlord’s consent, which shall not be unreasonably withheld or delayed, or
conditioned.

29. Each  Tenant  shall  keep  the  Premises  in  a  good  state  of  cleanliness  (without  limiting  or
waiving and subject to Landlord’s obligations for cleaning under the Lease), and for such purposes
shall,  during  the  term  of  the  Lease,  make  use  of  an  approved  cleaning  service  for  the  Building
when supplemental cleaning is desired by Tenant. No Tenant shall employ any person or persons
other than an approved cleaning service for the Building for the purpose of cleaning, or of taking
charge  of  the  Premises  unless  other  arrangements  have  been  approved  by  Landlord  in  writing.
Each Tenant agrees that the Landlord shall not be responsible to any Tenant for any damage or loss
of  property  within  the  Premises,  except  to  the  extent  arising  from  the  negligence  or  willful
misconduct of Landlord or its employees, contractors, agents or invitees.

30. Tenant  shall  not  install,  attach  or  modify  any  appurtenances  to  the  plumbing  or  HVAC
systems  without  the  Landlord’s  prior  written  consent  and  Tenant  shall  indemnify  and  hold
Landlord  harmless  from  any  and  all  loss  occasioned  by  the  installation,  modification  or
attachments of said appurtenances.

31. Tenant shall not be permitted to use or keep in the Property any kerosene, burning fluid, or
other illuminating material,  inflammable,  explosive,  corrosive  or  otherwise  harmful substance or
materials, except as is customary in office or computer facilities, without the Landlord’s consent.
Notwithstanding such consent, Tenant shall be solely liable and responsible for ensuring that  such
material  is  kept,  maintained,  stored,  destroyed,  disposed  and  discharged  in  accordance  with  all
applicable federal, state, regulatory and local laws, regulations and ordinances as well as industry
standards  and  practices.  Tenant  shall  indemnify  and  hold  Landlord  harmless  for  its  failure  to
comply with the above.

32. All complaints by a Tenant shall be made in writing to the Landlord. Each tenant shall give to
the Landlord’s Building superintendent prompt written notice of any damage known to Tenant or
defect in pipes, wires, appliances or fixtures in or about the premises and of any damage to any part
of the premises.

33. Landlord reserves the  right  to  rescind  any  of  these  rules  and  regulations  and  to make such
other  and  further  rules  and  regulations  as  in  its  reasonable  judgment  shall  from  time  to  time,  be
required for the safety, protection, care and cleanliness of the Building, the operation thereof, the

preservation of good order therein and the protection and comfort of the tenants and their agents,
employees and invitees. Such rules and regulations, when made and written notice thereof is given to
a tenant, shall be binding upon it in like manner as if originally herein prescribed.

EXHIBIT F
Sample Commencement Date Agreement

The  Parties  hereto,  Prospect  Fifth  Ave,  LLC,  (“Landlord”)  and     
(“Tenant”), are Parties under a certain Commercial Lease (“Lease”) dated _

rentable  square  feet  +  or  -  being  a  portion  of  the 

, for approximately
floor  at  400  Fifth  Ave,  Waltham,  MA
(“Premises”),  and  hereby  agree  for  mutual  consideration,  the  receipt  of  which  is  hereby
acknowledged by both parties, as follows:

1.

2.

3.
4.
5.

6.

7.

8.

As used in the Lease, the term “Commencement Date” shall mean

; and

As used in the Lease, the term “Rent Commencement Date” shall mean

; and

to

; and

; and

and on

As used in the Lease, the term “Expiration Date” shall mean
The first Lease Year shall be from
which was previously paid by the Tenant pursuant to
The amount of $
Section  1.2  of  the  Lease  shall  be  applied  to  the  installment  of  monthly  base  rent
commencing on
the Tenant shall make a
partial payment to bring the Tenant’s account current (strike if not applicable); and
Thereafter all payments shall be made on the first of each month pursuant to the Lease;
and
If there are any inconsistencies between this agreement and the Lease, the terms of  the
Lease Agreement shall prevail; and
Tenant  accepts  the  Premises  in  the  condition  required  by  the  Lease  and  otherwise  in
“As-Is” condition. Tenant acknowledges that the all work contemplated pursuant to the
Lease,  has  been  completed  to  the  full  satisfaction  of  the  Tenant  or  is  subject  to
completion

following

punchlist

the

of

items:
.

All other terms and provisions under the Lease shall remain unchanged and are hereby ratified and
affirmed.

IN  WITNESS  WHEREOF,  the  said  Parties  hereto  set  their  hands  and  seals  this  day of

, 20   .

TENANT

LANDLORD
Prospect Fifth Ave LLC

,

Duly Authorized

Duly Authorized

  
   
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
  
 
EXHIBIT G

Appraisal Methodology for Extension Option Basic Rent

Within  ten  (10)  Business  Days  after  the  expiration  of  the  FMR  Resolution  Period  (the  “Broker
Selection Deadline”), the parties shall each appoint an licensed commercial broker who has at least
ten  (10)  years  of  experience  and  is  knowledgeable  in  office  rentals  in  the  market  where  the
Building is located. The two brokers shall together appoint a third licensed commercial real estate
broker with the same qualifications, but the third commercial broker shall not have been hired or
worked for either party for the past three (3) years. The three (3) brokers shall then each determine
within  twenty  (20)  days  the  then  fair  market  value  rental  rate  (taking  into  account  leasehold
improvements, allowances, rent abatements, commissions and other prevailing market concessions
and allowances) for such space, taking into consideration the office rental market in Boston Metro
West  area  for  comparable  space  and  the  rental  rates  then  being  quoted  to  new  tenants  for
comparable office space in the Building and other comparable office buildings in the Boston Metro
West  area.  The  fair  market  value  rental  rate  (Basic  Rent)  for  the  extension  option  term  shall
thereafter be determined to be the amount equal to: (x) the average of the two appraisals which are
closest in dollar amount to each other except that if all three appraisals are apart in equal amounts,
the appraisal which falls in the middle shall be the fair market value rental rate and yearly increases
on the anniversary of the commencement date of the extension term. If either party fails to select a
broker by the Broker Selection Deadline, then the broker selected by the other party, if selected by
the Broker Selection Deadline, shall be the sole broker. Landlord and Tenant shall share equally the
expense  of  any  and  all  brokers.  The  broker(s)  shall  be  obligated  to  make  a  determination  of  fair
market value rental rate within thirty (30) days of the appointment of either the single broker (if
only  one)  and  within  thirty  (30)  days  of  the  appointment  of  the  third  broker  (if  three  are  so
appointed).

In determining the fair market value rental rate for the extension term, the brokers shall consider,
among  other  things,  the  then  current  arms’  length  basic  rent  being  charged  to  tenants  for
comparable buildings in the Boston Metro West area market area.

The brokers shall not have the right to modify any provision of this Lease and shall only determine
the fair market value rental rate as provided above for purposes of determination of the Basic Rent
under this Lease for the extension term, subject to the limitations provided above.

The Tenant, after receiving the determination by the brokers, may decide not to exercise the option
by  providing  notice  to  Landlord  within  ten  (10)  days  of  receiving  the  determination.  Failure  to
provide timely notice shall constitute de facto exercise of the option at the fair market rental rate
determined by the brokers.

EXHIBIT H

FORM LETTER OF CREDIT

IRREVOCABLE STANDBY LETTER OF CREDIT NO.

DATE:
BENEFICIARY:

APPLICANT:

Burlington, Massachusetts 01803
AS “TENANT”

AMOUNT: US $
AND 00/100 U.S. DOLLARS)

(

EXPIRATION DATE:   

LOCATION:  AT  OUR  COUNTERS  IN  BOSTON,  MASSACHUSETTS

DEAR SIR/MADAM:

WE  HEREBY  ESTABLISH  OUR  IRREVOCABLE  STANDBY  LETTER  OF  CREDIT  NO.

IN YOUR FAVOR AVAILABLE BY YOUR DRAFT DRAWN ON US AT SIGHT IN THE

FORM OF EXHIBIT "B" ATTACHED AND ACCOMPANIED BY THE FOLLOWING DOCUMENTS:

1. THE ORIGINAL OF THIS LETTER OF CREDIT AND ALL AMENDMENT(S), IF
ANY.
2. A  DATED  CERTIFICATION  FROM  THE  BENEFICIARY  SIGNED  BY  AN  AUTHORIZED
OFFICER OR AGENT, FOLLOWED BY ITS DESIGNATED TITLE, STATING THE FOLLOWING:

(A)
“THE  AMOUNT  REPRESENTS  FUNDS  DUE  AND  OWING  TO  US  FROM
APPLICANT  PURSUANT  TO  THAT  CERTAIN  LEASE  BY  AND  BETWEEN
BENEFICIARY, AS LANDLORD, AND APPLICANT, AS TENANT.”

OR

(B) “WE  HEREBY  CERTIFY  THAT  WE  HAVE  RECEIVED  NOTICE  FROM

BANK  THAT  LETTER  OF  CREDIT  NO.

WILL  NOT  BE  RENEWED,  AND  THAT  WE  HAVE  NOT
RECEIVED A REPLACEMENT OF THIS LETTER OF CREDIT FROM APPLICANT
SATISFACTORY  TO  US  AT  LEAST  THIRTY  (30)  DAYS  PRIOR  TO  THE
EXPIRATION DATE OF THIS LETTER OF CREDIT.”

  
    
 
  
 
  
 
  
 
IRREVOCABLE STANDBY LETTER OF CREDIT NO. 
DATED

THE  LEASE  AGREEMENT  MENTIONED  ABOVE  IS  FOR  IDENTIFICATION  PURPOSES  ONLY
AND  IT  IS  NOT  INTENDED  THAT  SAID  LEASE  AGREEMENT  BE  INCORPORATED  HEREIN  OR
FORM PART OF THIS LETTER OF CREDIT.

OUR  OBLIGATION  UNDER  THIS  CREDIT  SHALL  NOT  BE  AFFECTED  BY  ANY
CIRCUMSTANCES,  CLAIM  OR  DEFENSE,  REAL  OR  PERSONAL,  OF  ANY  PARTY  AS  TO  THE
ENFORCEABILITY  OF  THE  LEASE  BETWEEN  YOU  AND  TENANT,  IT  BEING  UNDERSTOOD
THAT  OUR  OBLIGATION  SHALL  BE  THAT  OF  A  PRIMARY  OBLIGOR  AND  NOT  THAT  OF  A
SURETY,  GUARANTOR  OR  ACCOMMODATION  MAKER.  IF  YOU  DELIVER  THE  WRITTEN
CERTIFICATE  REFERENCED  ABOVE  TO  US,  (I)  WE  SHALL  HAVE  NO  OBLIGATION  TO
DETERMINE  WHETHER  ANY  OF  THE  STATEMENTS  THEREIN  ARE  TRUE,  (II)  OUR
OBLIGATIONS  HEREUNDER  SHALL  NOT  BE  AFFECTED  IN  ANY  MANNER  WHATSOEVER  IF
THE STATEMENTS MADE IN SUCH CERTIFICATE ARE UNTRUE IN WHOLE OR IN PART, AND
(III)  OUR  OBLIGATIONS  HEREUNDER  SHALL  NOT  BE  AFFECTED  IN  ANY  MANNER
WHATSOEVER  IF  TENANT  DELIVERS  INSTRUCTIONS  OR  CORRESPONDENCE  TO  WHICH
EITHER  (A)  DENIES  THE  TRUTH  OF  THE  STATEMENT  SET  FORTH  IN  THE  CERTIFICATE
REFERRED  TO  ABOVE,  OR  (B)  INSTRUCTS  US  NOT  TO  PAY  BENEFICIARY  ON  THIS  CREDIT
FOR ANY REASON WHATSOEVER.

PARTIAL  AND  MULTIPLE  DRAWS  ARE  ALLOWED.  EXCEPT  AS  EXPRESSLY  SET  FORTH
HEREIN,  THIS  LETTER  OF  CREDIT  MUST  ACCOMPANY  ANY  DRAWINGS  HEREUNDER  FOR
ENDORSEMENT  OF  THE  DRAWING  AMOUNT  AND  WILL  BE  RETURNED  TO  THE
BENEFICIARY UNLESS IT IS FULLY UTILIZED.

DRAFT(S) AND DOCUMENTS MUST INDICATE THE NUMBER AND DATE OF THIS LETTER OF
CREDIT.

THIS  LETTER  OF  CREDIT  SHALL  BE  AUTOMATICALLY  EXTENDED  FOR  AN  ADDITIONAL
PERIOD  OF  ONE  YEAR,  WITHOUT  AMENDMENT,  FROM  THE  PRESENT  OR  EACH  FUTURE
EXPIRATION  DATE  UNLESS  AT  LEAST  SIXTY  (60)  DAYS  PRIOR  TO  THE  THEN  CURRENT
EXPIRATION DATE WE NOTIFY YOU BY REGISTERED MAIL/OVERNIGHT COURIER SERVICE AT
THE ABOVE ADDRESSES THAT THIS LETTER OF CREDIT WILL NOT BE EXTENDED BEYOND
THE  CURRENT  EXPIRATION  DATE.  IN  NO  EVENT  SHALL  THIS  LETTER  OF  CREDIT  BE
AUTOMATICALLY EXTENDED BEYOND [SIX (6) MONTHS BEYOND LEASE EXPIRATION].

THIS  LETTER  OF  CREDIT  MAY  BE  TRANSFERRED  WITHOUT  COST  TO  THE  BENEFICIARY,
ONE  OR  MORE  TIMES  BUT  IN  EACH  INSTANCE  TO  A  SINGLE  BENEFICIARY  AND  ONLY  IN
THE  FULL  AMOUNT  AVAILABLE  TO  BE  DRAWN  UNDER  THE  LETTER  OF  CREDIT  AT  THE
TIME  OF  THE  TRANSFER  AND  ONLY  BY  THE  ISSUING  BANK  UPON  OUR  RECEIPT  OF  THE
ATTACHED  “EXHIBIT  A”  DULY  COMPLETED  AND  EXECUTED  BY  THE  BENEFICIARY  AND
ACCOMPANIED BY THE ORIGINAL LETTER OF CREDIT AND ALL AMENDMENTS, IF ANY.

ALL  DEMANDS  FOR  PAYMENT  SHALL  BE  MADE  BY  PRESENTATION  OF  THE  ORIGINAL
APPROPRIATE DOCUMENTS PRIOR TO 10:00 A.M.  E.S.T.  TIME,  ON  A  BUSINESS  DAY  AT  OUR
OFFICE (THE “BANK’S OFFICE”) AT: 

  
 
  
 
BOSTON, MASSACHUSETTS  
FACSIMILE   TRANSMISSION   AT:   (617)
TELEPHONE   ADVICE   TO:   (617)
ORIGINALS TO FOLLOW BY OVERNIGHT COURIER SERVICE.

, ATTENTION:
-

-

, ATTENTION:    

   OR BY
;   AND   SIMULTANEOUSLY   UNDER

WITH

PAYMENT  AGAINST  CONFORMING  PRESENTATIONS  HEREUNDER  SHALL  BE  MADE  BY
BANK  DURING  NORMAL  BUSINESS  HOURS  OF  THE  BANK’S  OFFICE  WITHIN  ONE  (1)
BUSINESS DAY AFTER PRESENTATION.

WE HEREBY AGREE WITH THE DRAWERS, ENDORSERS AND BONAFIDE HOLDERS THAT THE
DRAFTS  DRAWN  UNDER  AND  IN  ACCORDANCE  WITH  THE  TERMS  AND  CONDITIONS  OF
THIS  LETTER  OF  CREDIT  SHALL  BE  DULY  HONORED  UPON  PRESENTATION  TO  THE
DRAWEE, IF NEGOTIATED ON OR BEFORE THE EXPIRATION DATE OF THIS CREDIT.

PAGE 2 OF 3

 
  
 
  
 
  
    
 
  
    
 
  
 
THIS  LETTER  OF  CREDIT  IS  SUBJECT  TO  THE  UNIFORM  CUSTOMS  AND  PRACTICE  FOR
DOCUMENTARY  CREDITS  (1993  REVISION),  INTERNATIONAL  CHAMBER  OF  COMMERCE,
PUBLICATION NO. 500.

AUTHORIZED SIGNATURE

AUTHORIZED

SIGNATURE

EXHIBIT “A”

DATE:

TO:

RE: STANDBY LETTER OF CREDIT

NO.

ATTN:

AMOUNT:

LADIES AND GENTLEMEN:

ISSUED BY

L/C

FOR  VALUE  RECEIVED,  THE  UNDERSIGNED  BENEFICIARY  HEREBY 
TRANSFERS TO:

IRREVOCABLY

(NAME OF TRANSFEREE)
(ADDRESS)

ALL  RIGHTS  OF  THE  UNDERSIGNED  BENEFICIARY  TO  DRAW  UNDER  THE  ABOVE  LETTER
OF  CREDIT  UP  TO  ITS  AVAILABLE  AMOUNT  AS  SHOWN  ABOVE  AS  OF  THE  DATE  OF  THIS
TRANSFER.

BY THIS TRANSFER, ALL RIGHTS OF THE UNDERSIGNED BENEFICIARY IN SUCH LETTER OF
CREDIT  ARE  TRANSFERRED  TO  THE  TRANSFEREE.  TRANSFEREE  SHALL  HAVE  THE  SOLE
RIGHTS  AS  BENEFICIARY  THEREOF,  INCLUDING  SOLE  RIGHTS  RELATING  TO  ANY
AMENDMENTS,  WHETHER  INCREASES  OR  EXTENSIONS  OR  OTHER  AMENDMENTS,  AND
WHETHER NOW EXISTING OR HEREAFTER MADE. ALL AMENDMENTS ARE TO BE ADVISED
DIRECT  TO  THE  TRANSFEREE  WITHOUT  NECESSITY  OF  ANY  CONSENT  OF  OR  NOTICE  TO
THE UNDERSIGNED BENEFICIARY.

THE ORIGINAL OF SUCH LETTER OF CREDIT IS RETURNED HEREWITH, AND WE ASK YOU
TO ENDORSE THE TRANSFER ON THE REVERSE THEREOF, AND FORWARD IT DIRECTLY TO
THE TRANSFEREE WITH YOUR CUSTOMARY NOTICE OF TRANSFER.

SINCERELY,

(BENEFICIARY’S NAME)

SIGNATURE OF BENEFICIARY

SIGNATURE AUTHENTICATED

(NAME OF BANK)

AUTHORIZED SIGNATURE

EXHIBIT “B”

Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1)      Registration Statement on Form S-8 (No. 333-197408) pertaining to the 2008 Stock Incentive Plan, as amended,

the 2014 Equity Incentive Award Plan and the 2014 Employee Stock Purchase Plan of Ardelyx, Inc.

(2)      Registration Statements on Form S-8 (Nos. 333-202663 and 333-230156) pertaining to the 2014 Equity

Incentive Award Plan and the 2014 Employee Stock Purchase Plan of Ardelyx, Inc.

(3)      Registration Statements on Form S-3 (Nos. 333-205630, 333-213085 and 333-239764) of Ardelyx, Inc.

(4)      Registration Statements on Form S-8 (Nos. 333-210079, 333-216154, 333-223694 and 333-237057) pertaining

to the 2014 Equity Incentive Award Plan of Ardelyx, Inc.

(5)      Registration Statement on Form S-8 (No. 333-214538) pertaining to the 2016 Employment Commencement

Incentive Plan of Ardelyx, Inc.

of our report dated March 8, 2021, with respect to the financial statements of Ardelyx, Inc. included in this Annual Report
(Form 10-K) of Ardelyx, Inc. for the year ended December 31, 2020.

/s/ Ernst & Young LLP

Redwood City, California
March 8, 2021

    
Exhibit 31.1

I, Michael Raab, certify that:

1.

I have reviewed this Annual Report on Form 10-K of Ardelyx, Inc.;

CERTIFICATION

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material
fact necessary to make the statements made, in light of the circumstances under which such statements were made, not
misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present

in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the
periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls
and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial
reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)

(b)

(c)

(d)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be
designed under our supervision, to ensure that material information relating to the registrant, including its
consolidated subsidiaries, is made known to us by others within those entities, particularly during the period
in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial
reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of
financial reporting and the preparation of financial statements for external purposes in accordance with
generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report
our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period
covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred
during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual
report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control
over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control
over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or
persons performing the equivalent functions):

(a)

(b)

All  significant  deficiencies  and  material  weaknesses  in  the  design  or  operation  of  internal  control  over
financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process,
summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role
in the registrant’s internal control over financial reporting.

Date: March 8, 2021

    By:

/s/ Michael Raab
Michael Raab
President, Chief Executive Officer and Director
(Principal Executive Officer)

Exhibit 31.2

I, Justin Renz, certify that:

1.

I have reviewed this Annual Report on Form 10-K of Ardelyx, Inc.;

CERTIFICATION

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material
fact necessary to make the statements made, in light of the circumstances under which such statements were made, not
misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present

in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the
periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls
and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial
reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

(a)

(b)

(c)

(d)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be
designed under our supervision, to ensure that material information relating to the registrant, including its
consolidated subsidiaries, is made known to us by others within those entities, particularly during the period
in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial
reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of
financial reporting and the preparation of financial statements for external purposes in accordance with
generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report
our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period
covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred
during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual
report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control
over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control
over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or
persons performing the equivalent functions):

(a)

(b)

All significant deficiencies and material weaknesses in the design or operation of internal control over
financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process,
summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role
in the registrant’s internal control over financial reporting.

Date: March 8, 2021

    By:

/s/ Justin Renz
Justin Renz
Chief Financial Officer
(Principal Financial Officer)

CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906
OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 32.1

In connection with the Annual Report of Ardelyx, Inc. (the “Company”) on Form 10-K for the period ending December 31, 2020, as

filed with the Securities and Exchange Commission on the date hereof (the “Report”), Michael Raab, President and Chief Executive
Officer of the Company, and Justin Renz, Chief Financial Officer of the Company, respectively, do each hereby certify, pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1)   The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)   The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations

of the Company.

Date: March 8, 2021

    By:

Date: March 8, 2021

By:

/s/ Michael Raab
Michael Raab
President, Chief Executive Officer and Director
(Principal Executive Officer)

/s/ Justin Renz
Justin Renz
Chief Financial Officer
(Principal Financial Officer)