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Ardelyx, Inc.

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FY2023 Annual Report · Ardelyx, Inc.
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Table of Contents

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
____________________________________________________

FORM 10-K
____________________________________________________

(Mark One)

 ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2023

OR



TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM                     TO                     

COMMISSION FILE NUMBER 001-36485
____________________________________________________

ARDELYX, INC.

(EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
____________________________________________________

DELAWARE

(STATE OR OTHER JURISDICTION OF

INCORPORATION OR ORGANIZATION)

26-1303944

(I.R.S. EMPLOYER

IDENTIFICATION NO.)

400 FIFTH AVE., SUITE 210, WALTHAM, MASSACHUSETTS 02451
(ADDRESS OF PRINCIPAL EXECUTIVE OFFICES, INCLUDING ZIP CODE)

(510) 745-1700
(REGISTRANT’S TELEPHONE NUMBER, INCLUDING AREA CODE)
____________________________________________________

Securities registered pursuant to Section 12(b) of the Act:

Title of Each Class

Common Stock, par value $0.0001 per share

Trading Symbol(s)

ARDX

Name of Each Exchange on Which Registered

The Nasdaq Global Market

Indicate by check mark if the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes  No 

Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes   No 

Securities registered pursuant to Section 12(g) of the Act: None
____________________________________________________

Indicate by check mark whether the Registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for
such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes  No 

Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter)
during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files). Yes  No 
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the
definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

Non-accelerated filer





Accelerated filer

Small reporting company

Emerging growth company







If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 13(a) of the Exchange Act. 

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section
404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. 
If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to
previously issued financial statements. ☐

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive
officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes  No 
The aggregate market value of the Registrant’s common stock held by non-affiliates of the Registrant as of the last business day of the Registrant’s most recently completed second fiscal quarter,
June 30, 2023, based on the last reported sales price of the Registrant’s common stock on the Nasdaq Global Market of $3.39 per share was $724,838,738.

The number of shares of Registrant’s Common Stock outstanding as of February 16, 2024, was 232,686,008.

DOCUMENTS INCORPORATED BY REFERENCE:

Portions of the Registrant’s Definitive Proxy Statement for its 2024 Annual Meeting of Stockholders, which will be filed with the Commission within 120 days of December 31, 2023, the close of
the Registrant’s 2023 fiscal year, are incorporated by reference into Part III of this Report.

NOTE REGARDING FORWARD-LOOKING STATEMENTS

Unless the context requires otherwise, in this Annual Report on Form 10-K the terms “Ardelyx”, “we,” “us,” “our” and “the Company” refer to Ardelyx,
Inc.

This Annual Report on Form 10-K contains forward-looking statements that involve risks and uncertainties. Any statements contained herein that are not
statements of historical facts may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terminology
such as “aim,” “anticipate,” “assume,” “believe,” “continue,” “could,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “predict,”
“potential,”  “positioned,”  “seek,”  “should,”  “target,”  “will,”  “would,”  and  other  similar  expressions  that  are  predictions  of  or  indicate  future  events  and
future trends, or the negative of these terms or other comparable terminology. These forward-looking statements include, but are not limited to, statements
about:

• whether or when XPHOZAH, along with other oral ESRD-related drugs without an injectable or intravenous equivalent, are bundled into the ESRD
prospective  payment  system  (ESRD  PPS),  and  the  manner  in  which  such  introduction  into  the  ESRD  PPS  may  occur,  including  the  length  of  any
applicable Transitional Drug Add-on Payment Adjustment (TDAPA) period; the amount of the add-on payment available during the TDAPA period
and whether, and the extent to which, the ESRD PPS base rate is adjusted following any applicable TDAPA period;

•

•

•

our plans with respect to RDX013 and RDX020;

estimates of our expenses, future revenue, capital requirements, our needs for additional financing and our ability to obtain additional capital; and

other risks and uncertainties, including those under the caption “Risk Factors.”

We have based these forward-looking statements largely on management’s current expectations, estimates, forecasts and projections about our business and
the  industry  in  which  we  operate  and  management’s  beliefs  and  assumptions,  and  these  forward-looking  statements  are  not  guarantees  of  future
performance or development and involve known and unknown risks, uncertainties and other factors that are in some cases beyond our control. Factors that
could cause actual results or conditions to differ from those anticipated by these and other forward-looking statements include those more fully described in
the  “ITEM  1A.  RISK  FACTORS”  section  and  elsewhere  in  this  Annual  Report  on  Form  10-K.  Except  as  required  by  law,  we  assume  no  obligation  to
update any forward-looking statement publicly, or to revise any forward-looking statement to reflect events or developments occurring after the date of this
Annual Report on Form 10-K, even if new information becomes available in the future. Thus, you should not assume that our silence over time means that
actual events are bearing out as expressed or implied in any such forward-looking statement.

Table of Contents

SUMMARY OF PRINCIPAL RISKS ASSOCIATED WITH OUR BUSINESS

The principal risks and uncertainties affecting our business include the following:

• We are not profitable and have incurred losses since our inception in October 2007, and we expect to continue to incur operating losses in the future as
we commercialize IBSRELA and XPHOZAH, incur manufacturing and development costs for tenapanor, and incur research and development costs
related to potential new product candidates.

• We will require additional financing for the foreseeable future as we invest in the commercialization of IBSRELA and XPHOZAH in the U.S, and

incur research and development cost related to potential new product candidates. The inability to access necessary capital when needed on acceptable
terms, or at all, could force us to reduce our efforts to commercialize IBSRELA and XPHOZAH, or to delay or limit our pursuit of potential new
product candidates.

•

• We have generated limited revenue from product sales and may never be profitable.
• We are substantially dependent on the successful commercialization of IBSRELA, and there is no guarantee that we will maintain sufficient market
acceptance for IBSRELA, grow market share for IBSRELA, secure and maintain adequate coverage and reimbursement for IBSRELA, or generate
sufficient revenue from product sales of IBSRELA.
There is no guarantee that we will achieve sufficient market acceptance for XPHOZAH, secure and maintain adequate coverage and reimbursement for
XPHOZAH, or generate sufficient revenue from product sales of XPHOZAH.
In the event no legislative or regulatory action is taken to further delay the inclusion of oral only ESRD related drugs in the ESRD prospective payment
system (ESRD PPS), XPHOZAH will become part of the ESRD PPS on January 1, 2025, and will no longer be separately paid for under Part D, and
as a result the revenue that we may generate on sales of XPHOZAH will be negatively and materially impacted.
IBSRELA and/or XPHOZAH may cause undesirable side effects or have other properties that could limit the commercial success of the product.
Third-party payor coverage and reimbursement status of newly commercialized products are uncertain. Failure to obtain or maintain adequate coverage
and reimbursement for IBSRELA and XPHOZAH could limit our ability to market those products and decrease our ability to generate revenue.
• We rely completely on third parties, including certain single-source suppliers, to manufacture IBSRELA and XPHOZAH. If they are unable to comply

•
•

•

with applicable regulatory requirements, unable to source sufficient raw materials, experience manufacturing or distribution difficulties or are
otherwise unable to manufacture sufficient quantities to meet demand, our commercialization of IBSRELA and XPHOZAH may be materially harmed.

• Our future results depend on contract manufacturing organizations (CMOs), many of whom are our single source manufacturers.
• Our operating activities may be restricted as a result of covenants related to the indebtedness under our loan and security agreement with SLR, as

amended, and we may be required to repay the outstanding indebtedness in an event of default, which could have a materially adverse effect on our
business.

The summary risk factors described above should be read together with the text of the full risk factors below in the section entitled “Risk Factors” and the
other information set forth in this Annual Report on Form 10-K, including our financial statements and the related notes, as well as in other documents that
we file with the U.S. Securities and Exchange Commission. The risks summarized above or described in full below are not the only risks that we face.
Additional risks and uncertainties not precisely known to us or that we currently deem to be immaterial may also materially adversely affect our business,
financial condition, results of operations, and future growth prospects.

NOTE REGARDING TRADEMARKS

®

®

ARDELYX , IBSRELA ,  and  XPHOZAH are  trademarks  of  Ardelyx.  All  other  trademarks,  trade  names  and  service  marks  appearing  in  this  Annual
Report on Form 10-K are the property of their respective owners.

® 

1

Table of Contents

ARDELYX, INC.
FORM 10-K FOR THE FISCAL YEAR ENDED December 31, 2023
TABLE OF CONTENTS

Item 1.

Item 1A.

Item 1B.

Item 1C.

Item 2.

Item 3.

Item 4.

Item 5.

Item 6.

Item 7.

Business

Risk Factors

Unresolved Staff Comments

Cybersecurity

Properties

Legal Proceedings

Mine Safety Disclosures

PART I

PART II

Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

[Reserved]

Management’s Discussion and Analysis of Financial Condition and Results of Operations

Item 7A.

Quantitative and Qualitative Disclosures About Market Risk

Financial Statements and Supplementary Data

Changes in and Disagreements with Accountants on Accounting and Financial Disclosure

Controls and Procedures

Other Information

Disclosure Regarding Foreign Jurisdictions that Prevent Inspection

PART III

Directors, Executive Officers and Corporate Governance

Executive Compensation

Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

Certain Relationships and Related Transactions, and Director Independence

Principal Accounting Fees and Services

PART IV

Exhibits, Financial Statement Schedules

Form 10-K Summary

Item 8.

Item 9.

Item 9A.

Item 9B.

Item 9C.

Item 10.

Item 11.

Item 12.

Item 13.

Item 14.

Item 15.

Item 16.

Signatures

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3

19

52

52

53

53

54

55

55

55

72

73

110

110

113

113

114

114

114

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119

Table of Contents

ITEM 1.    BUSINESS

Overview

We  are  a  biopharmaceutical  company  founded  with  a  mission  to  discover,  develop  and  commercialize  innovative  first-in-class  medicines  that  meet
significant unmet medical needs. We developed a unique and innovative platform that enabled the discovery of new biological mechanisms and pathways
to develop potent, and efficacious therapies that minimize the side effects and drug-drug interactions frequently encountered with traditional, systemically
absorbed  medicines.  The  first  molecule  we  discovered  and  developed  was  tenapanor,  a  minimally  absorbed,  first-in-class,  oral,  small  molecule  therapy.
Tenapanor, branded as IBSRELA , is approved in the U.S. for the treatment of adults with irritable bowel syndrome with constipation (IBS-C). Tenapanor,
branded as XPHOZAH , was approved by the U.S. Food and Drug Administration (U.S. FDA) on October 17, 2023, to reduce serum phosphorus in adults
with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of
any  dose  of  phosphate  binder  therapy.  We  also  have  a  development  stage  asset,  RDX013  for  adult  patients  with  CKD  and/or  heart  failure  with
hyperkalemia, or elevated serum potassium, and a discovery phase asset, RDX020 for adult patients with metabolic acidosis, a serious electrolyte disorder,
in patients with CKD.

®

®

Since  commencing  operations  in  October  2007,  substantially  all  our  efforts  have  been  dedicated  to  our  research  and  development  (R&D)  activities,
including developing tenapanor and developing our proprietary drug discovery and design platform, as well as commercialization activities, including the
marketing and sales of IBSRELA and XPHOZAH. We realized our first product sales of IBSRELA in March 2022 and realized our first product sales of
XPHOZAH in November 2023. As of December 31, 2023, we had an accumulated deficit of $846.2 million.

We  expect  to  continue  to  incur  operating  losses  for  the  foreseeable  future  as  we  invest  in  the  commercialization  of  IBSRELA  and  XPHOZAH,  incur
manufacturing  and  development  cost  for  tenapanor,  and  incur  R&D  cost  related  to  potential  new  product  candidates.  To  date,  we  have  funded  our
operations from the sale and issuance of common stock and convertible preferred stock, funds from our collaboration partnerships, which includes license
fees,  milestones  and  product  supply  revenue,  funds  from  our  loan  agreements  with  SLR  Investment  Corp.  (SLR),  as  amended,  as  well  as  from  sales  of
IBSRELA and XPHOZAH.

Our Commercial Products

IBSRELA for IBS-C

Our  unique  discovery  platform  and  deep  understanding  of  the  primary  mechanism  of  sodium  transport  in  the  intestine  resulted  in  our  discovery  and
development  of  IBSRELA,  a  first-in-class,  U.S.  FDA  approved,  sodium  hydrogen  exchange  3  (NHE3)  inhibitor  for  the  treatment  of  IBS-C  in  adults.
IBSRELA acts locally in the gut and is minimally absorbed. IBS-C is a gastrointestinal (GI) disorder characterized by both abdominal pain and altered
bowel habits. IBS-C is associated with significantly impaired quality of life, reduced productivity, and substantial economic burden.

We  recognized  our  first  sales  of  IBSRELA  in  the  U.S.  in  March  2022.  For  our  commercial  launch  of  IBSRELA,  we  designed  a  market-responsive
commercial strategy and built a commercial organization highly experienced in launching novel therapies into specialty areas. The dynamics of the IBS-C
market reflect an established patient base, limited number of competitors all confined to a single mechanism of action, concentrated number of prescribers,
and recognized unmet need. In addition, market research indicated a favorable response to the IBSRELA product profile as a novel mechanism therapy.
These dynamics enabled a targeted promotional focus on patients currently being managed for IBS-C by the approximately 9,000 high-writing healthcare
providers who account for approximately 50% of IBS-C prescriptions. Central to our go to market strategy for IBSRELA has been our highly experienced
specialty sales force, many with existing relationships across their GI target base, and innovative omnichannel and digital initiatives.

We  expect  competition  for  IBSRELA  will  come  largely  from  the  three  prescription  products  indicated  for  IBS-C:  Linzess  (linaclotide),  Amitiza
(lubiprostone)  and  Trulance  (plecanatide).  Generic  lubiprostone  is  also  available  in  the  U.S.  Additionally,  over-the-counter  products  and  prescription
therapies, not indicated for IBS-C are commonly used to treat the constipation component of IBS-C, alone and in combination with the IBS-C-indicated
prescription therapies.

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We have established commercial agreements with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. (Fosun Pharma) in China and Knight
Therapeutics, Inc. (Knight) in Canada for IBSRELA for IBS-C. Knight is currently marketing IBSRELA in Canada. In October 2023, we announced that
Fosun Pharma received approval from the Hong Kong Department of Health for the marketing application for tenapanor for the treatment of IBS-C.

XPHOZAH  to  Reduce  Serum  Phosphorus  in  Adults  with  CKD  on  Dialysis  as  Add-on  Therapy  in  Patients  Who  Have  an  Inadequate  Response  to
Phosphate Binders or Who are Intolerant of Any Dose of Phosphate Binder Therapy

On  October  17,  2023,  XPHOZAH,  a  first-in-class  phosphate  absorption  inhibitor,  received  approval  from  the  U.S.  FDA  to  be  marketed  in  the  U.S.  to
reduce serum phosphorus in adults with CKD on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are
intolerant of any dose of phosphate binder therapy. XPHOZAH has a differentiated mechanism of action and acts locally in the gut to inhibit NHE3. This
results in the tightening of the epithelial cell junctions, thereby significantly reducing paracellular uptake of phosphate, the primary pathway of phosphate
absorption.  It  is  estimated  that  there  are  more  than  550,000  adult  patients  with  CKD  on  dialysis  in  the  U.S.  and  approximately  eighty  percent  of  those
patients are being treated with phosphate lowering therapies. On average during 2020 through 2023, approximately seventy percent of patients treated with
phosphate binders to treat hyperphosphatemia were unable to consistently maintain phosphorous levels <=5.5 mg/dL over a six-month period. XPHOZAH
is the first therapy for phosphate management that blocks phosphate absorption at the primary site of uptake.

We recognized our first sales of XPHOZAH in the U.S. in November 2023. For our commercial launch of XPHOZAH, we designed a market-responsive
commercial  strategy  and  built  a  commercial  organization  highly  experienced  and  knowledgeable  of  the  nephrology  market.  The  dynamics  of  the
hyperphosphatemia market reflect an established patient base, limited number of competitors all confined to a single mechanism of action, concentrated
number of prescribers, and recognized unmet need. In addition, market research indicated a high level of awareness, interest and intent to adopt XPHOZAH
upon approval and favorable response to the XPHOZAH product profile as a novel mechanism therapy. These dynamics enabled a targeted promotional
focus on patients currently being managed for hyperphosphatemia by the approximately 8,000 nephrology healthcare providers who write approximately
80% of phosphate lowering therapy prescriptions. Central to our go to market strategy for XPHOZAH is our highly experienced specialty sales force, many
with existing relationships across their nephrology target base, and innovative omnichannel digital initiatives.

XPHOZAH is indicated to reduce serum phosphorus in adults with CKD on dialysis as add-on therapy in patients who have an inadequate response to
phosphate  binders  or  who  are  intolerant  of  any  dose  of  phosphate  binder  therapy.  The  various  types  of  phosphate  binders  commercialized  in  the  U.S.
include  the  following:  Calcium  acetate  (several  prescription  brands  including  PhosLo  and  Phoslyra);  Lanthanum  carbonate  (Fosrenol);  Sevelamer
hydrochloride (Renagel); Sevelamer carbonate (Renvela); Sucroferric oxyhydroxide (Velphoro); and Ferric citrate (Auryxia). All of the listed phosphate
binders are available as generics in the U.S., with the exception of Velphoro and Auryxia. Additionally, over-the-counter calcium carbonate, such as Tums
and Caltrate, is also used to bind phosphorus.

In addition to the currently available phosphate binders, we are aware of at least four other binders in development, including fermagate (Alpharen), an
iron-based binder in Phase 3 being developed by Opko Health, Inc., PT20, an iron-based binder in Phase 3 being developed by Shield Therapeutics, AP-
301  in  Phase  2  being  developed  by  Alebund  Pharmaceutical  (Hong  Kong)  Limited,  and  Oxylanthanum  Carbonate  (OLC),  which  has  demonstrated
pharmacodynamic bioequivalence to Fosrenol. OLC is being developed by Unicycive Therapeutics, which has announced its plans to seek FDA approval
via the 505(b)(2) pathway. Additionally, Chugai and Alebund are developing EOS789, an inhibitor of phosphate transporters NaPi-2b, PiT-1, and PiT-2,
thus far studied in a phase 1 clinical trial.

In November 2023, XPHOZAH was granted orphan drug designation by the U.S. FDA for the treatment of pediatric hyperphosphatemia.

We  have  established  commercial  agreements  with  Kyowa  Kirin,  Co.  Ltd.  (Kyowa  Kirin)  in  Japan,  Fosun  Pharma  in  China  and  Knight  in  Canada  for
tenapanor for hyperphosphatemia. In July 2023, we announced that a New Drug Application (NDA) for tenapanor had been accepted for review by China’s
Center for Drug Evaluation of the National Medical Products Administration (NMPA) for the control of serum phosphorus in adult patients with CKD on
hemodialysis. In September 2023, we announced that Kyowa Kirin received approval from the Japanese Ministry of Health, Labour and Welfare (MHLW)
for the NDA for tenapanor for the improvement of hyperphosphatemia in adult patients with CKD on dialysis.

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Discovery and Developmental Assets

We  have  a  small  molecule  potassium  secretagogue  program,  RDX013,  for  the  potential  treatment  of  hyperkalemia,  or  elevated  serum  potassium.
Hyperkalemia is a common problem in patients with heart and kidney disease, particularly in patients taking customary blood pressure medications known
as renin-angiotensin-aldosterone system (RAAS) inhibitors. RDX013 is a novel mechanism agent designed to target the underlying biological mechanisms
of potassium secretion to lower elevated potassium. We have completed a Phase 2 dose ranging clinical trial evaluating the safety and efficacy of RDX013
for the treatment of hyperkalemia in CKD patients who are not on dialysis. While the results of the study demonstrated an acceptable safety and tolerability
profile  for  RDX013  and  supported  proof  of  concept  in  its  ability  to  lower  serum  potassium  levels,  with  statistically  significant  reductions  compared  to
placebo after eight days of treatment, the study did not meet its primary endpoint of significantly reducing serum potassium levels compared to placebo
after four weeks of treatment.

We  have  a  discovery  program  targeting  the  inhibition  of  the  chloride  bicarbonate  exchanger  for  the  treatment  of  metabolic  acidosis,  a  highly  prevalent
comorbidity in CKD patients that is strongly correlated with disease progression and adverse outcomes. We have identified lead compounds that are potent,
selective and proprietary inhibitors of bicarbonate secretion.

We do not currently expect to meaningfully advance either of these two assets until such time as we have determined our available resources can support
additional activities after prioritization of the commercialization of IBSRELA and XPHOZAH.

Our Commercial Strategy

We have developed a portfolio of novel products to address unmet medical needs across gastrointestinal and cardiorenal therapeutic areas and intend to
commercialize our products in the U.S. We have established a high-quality commercial organization highly experienced in bringing novel products to our
customers,  including  patients,  payors  and  healthcare  providers.  Our  commercial  capabilities,  including  marketing,  access,  patient  services  and  sales  are
designed to support our commercialization of IBSRELA and XPHOZAH. We have executed ex-U.S. collaborations with established industry leaders to
efficiently bring XPHOZAH and IBSRELA to patients in specific territories outside of the U.S.

We continue to evaluate our strategy for the commercialization of IBSRELA and XPHOZAH in other ex-U.S. territories.

Collaboration Partners

We have exclusive rights to tenapanor in the U.S. and we have established agreements with Kyowa Kirin in Japan, Fosun Pharma in China and Knight in
Canada for the development and commercialization of tenapanor for certain indications in their respective territories.

In March 2018, we entered into an exclusive license agreement with Knight (Knight Agreement) for the development, commercialization and distribution
of  tenapanor  in  Canada  for  hyperphosphatemia  and  IBS-C.  In  March  2021,  Knight  announced  the  commercial  availability  of  IBSRELA  for  IBS-C  in
Canada, following its approval by Health Canada in April 2020. Under the terms of the Knight Agreement, Knight paid us a $2.3 million non-refundable,
one-time payment in March 2018. We may also be eligible to receive approximately CAD 22.2 million for development and commercialization milestones,
or approximately $16.7 million at the currency exchange rate on December 31, 2023, of which $0.7 million has been received and recognized as revenue as
of December 31, 2023. We are also eligible to receive royalties throughout the term of the agreement, and a transfer price for manufacturing services.

In  November  2017,  we  entered  into  an  exclusive  license  agreement  with  Kyowa  Kirin  (2017  Kyowa  Kirin  Agreement)  for  the  development,
commercialization and distribution of tenapanor in Japan for cardiorenal indications. Under the terms of the 2017 Kyowa Kirin Agreement, we received a
$30.0 million upfront payment from Kyowa Kirin, and we may be entitled to receive up to $55.0 million in total development and regulatory milestones, of
which $35.0 million has been received and recognized as revenue as of December 31, 2023. We may also be eligible to receive approximately ¥8.5 billion
for commercialization milestones, or approximately $60.3 million at the currency exchange rate on December 31, 2023, as well as reimbursement of costs
plus a reasonable overhead for the supply of product and royalties on net sales throughout the term of the agreement. As discussed in Note 8. Deferred
Royalty Obligation Related to the Sale of Future Royalties, the future royalties and commercial milestone payments we may receive under the 2017 Kyowa
Kirin Agreement will be remitted to HealthCare Royalty Partners IV, L.P. pursuant to a Royalty and Sales Milestone Interest Acquisition Agreement.

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On  April  11,  2022,  we  entered  into  a  second  amendment  to  the  2017  Kyowa  Kirin  Agreement  (2022  Amendment).  Under  the  terms  of  the  2022
Amendment, we and Kyowa Kirin agreed to a reduction in the royalty rate payable to us by Kyowa Kirin upon net sales of tenapanor in Japan. The royalty
rate was reduced from the high teens to low double digits for a two-year period of time following the first commercial sale in Japan, and then to mid-single
digits  for  the  remainder  of  the  royalty  term.  As  discussed  in  Note  8.  Deferred  Royalty  Obligation  Related  to  the  Sale  of  Future  Royalties,  the  future
royalties we may receive under the 2017 Kyowa Kirin Agreement will be remitted to HealthCare Royalty Partners IV, L.P. pursuant to a Royalty and Sales
Milestone  Interest  Acquisition  Agreement.  As  consideration  for  the  reduction  in  the  royalty  rate,  Kyowa  Kirin  agreed  to  pay  us  up  to  an  additional
$40.0 million which has been received and recognized as revenue as of September 2023 as described below.

In October 2022, we announced that Kyowa Kirin submitted an NDA to the Japanese MHLW for tenapanor for the improvement of hyperphosphatemia in
adult patients with CKD on dialysis, which resulted in payment to us from Kyowa Kirin for an aggregate of $35.0 million for milestone payments and
payments under the 2022 Amendment.

In  September  2023,  we  announced  that  Kyowa  Kirin  received  approval  from  the  Japanese  MHLW  for  the  NDA  for  tenapanor  for  the  improvement  of
hyperphosphatemia in adult patients with chronic kidney disease on dialysis, which resulted in payment to us from Kyowa Kirin for an aggregate of $30.0
million for milestone payments and payments under the 2022 Amendment.

In December 2017, we entered into an exclusive license agreement with Fosun Pharma (Fosun Agreement) for the development and commercialization of
tenapanor in China for both hyperphosphatemia and IBS-C. Under the terms of the Fosun Agreement, Fosun paid us a $12.0 million upfront license fee. In
July 2023, we announced that an NDA for tenapanor had been accepted for review by China’s Center for Drug Evaluation of the NMPA for the control of
serum phosphorus in adult patients with chronic kidney disease on hemodialysis. This acceptance triggered a $2.0 million milestone payment to us under
the terms of the Fosun Agreement, which we received in the third quarter of 2023.

In October 2023, we announced that the U.S. FDA has approved XPHOZAH to reduce serum phosphorus in adults with CKD on dialysis as add-on therapy
in  patients  who  have  an  inadequate  response  to  phosphate  binders  or  who  are  intolerant  of  any  dose  of  phosphate  binder  therapy.  This  triggered  an
additional $3.0 million milestone payment to us under the terms of the Fosun Agreement, which was received during the first quarter of 2024. Also, in
October 2023, we announced that Fosun Pharma received approval from the Hong Kong Department of Health for the marketing application for tenapanor
for the treatment of IBS-C. We may be entitled to receive development and commercialization milestones of up to $113.0 million, of which $8.0 million
has been recognized as revenue and $5.0 million has been received as of December 31, 2023 and $3.0 million was received in January 2024, as well as
reimbursement of cost plus a reasonable overhead for the supply of product and tiered royalties on net sales ranging from the mid-teens to 20%.

Corporate Financings

In  July  2020,  we  filed  a  Form  S-3  registration  statement,  which  became  effective  in  August  2020  (2020  Registration  Statement),  containing  (i)  a  base
prospectus for the offering, issuance and sale by us of up to a maximum aggregate offering price of $250.0 million of our common stock, preferred stock,
debt securities, warrants and/or units, from time to time in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by us
of up to a maximum aggregate offering price of $100.0 million of our common stock that may be issued and sold, from time to time, under an Open Market
Sales Agreement with Jefferies LLC (Jefferies), as sales agent, deemed to be “at-the-market offerings” (2020 Open Market Sales Agreement). Pursuant to
the 2020 Open Market Sales Agreement, Jefferies, as sales agent, received a commission of up to 3.0% of the gross sales price for shares of common stock
sold  under  the  2020  Open  Market  Sales  Agreement.  We  sold  a  cumulative  total  of  23.3  million  shares  and  received  the  full  gross  proceeds  of  $100.0
million at a weighted average sales price of approximately $4.30 per share under the 2020 Open Market Sales Agreement.

In August 2021, we filed an additional prospectus supplement under the 2020 Registration Statement for the offering, issuance and sale by us of up to a
maximum  aggregate  offering  price  of  $150.0  million  of  our  common  stock  that  we  were  authorized  to  issue  and  sell,  from  time  to  time,  under  a  sales
agreement (2021 Open Market Sales Agreement) we entered into with Jefferies, pursuant to which we, from time to time, sold up to $150.0 million in
shares of our common stock through Jefferies. Pursuant to the 2021 Open Market Sales Agreement, Jefferies, as our sales agent, received a commission of
up to 3.0% of the gross sales price for shares of common stock sold under the 2021 Open Market Sales Agreement. As of March 2023, we had received the
maximum gross proceeds of $150.0 million under the 2021 Open Market Sales Agreement at a weighted average share price of approximately $1.57 per
share, which included 15.5 million shares of our common stock for which we received gross proceeds of $51.9 million at a weighted average share price of
approximately $3.35 during the quarter ended March 31, 2023.

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In January 2023, we filed a Form S-3 registration statement, which became effective in January 2023 (2023 Registration Statement), containing (i) a base
prospectus for the offering, issuance and sale by us of up to a maximum aggregate offering price of $250.0 million of our common stock, preferred stock,
debt securities, warrants and/or units, from time to time in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by us
of  up  to  a  maximum  aggregate  offering  price  of  $150.0  million  of  our  common  stock  that  may  be  issued  and  sold,  from  time  to  time,  under  a  sales
agreement  with  Jefferies,  deemed  to  be  “at-the-market  offerings”  (2023  Open  Market  Sales  Agreement).  Pursuant  to  the  2023  Open  Market  Sales
Agreement, Jefferies, as sales agent, may receive a commission of up to 3.0% of the gross sales price for shares of common stock sold under the 2023 Open
Market Sales Agreement. During the year ended December 31, 2023, we completed sales pursuant to the 2023 Open Market Sales Agreement resulting in
the issuance of 16.8 million shares of our common stock and receipt of gross proceeds of $70.0 million at a weighted average sales price of approximately
$4.17 per share.

As of December 31, 2023, we had cash, cash equivalents and short-term investments totaling $184.3 million.

Intellectual Property

Our commercial success depends in part on our ability to obtain and maintain proprietary protection for our products, drug candidates, manufacturing and
process discoveries, and other know-how, to operate without infringing the proprietary rights of others and to prevent others from infringing our proprietary
rights.  Our  policy  is  to  seek  to  protect  our  intellectual  property  by,  among  other  methods,  filing  U.S.  and  foreign  patent  applications  related  to  our
proprietary  technology  and  inventions  that  are  important  to  the  development  and  operation  of  our  business.  We  also  rely  on  trade  secrets  and  careful
monitoring of our proprietary information to protect aspects of our business that are not amenable to, or that we do not consider appropriate for, patent
protection.

The  patent  positions  of  biopharmaceutical  companies  like  us  are  generally  uncertain  and  involve  complex  legal,  scientific  and  factual  questions.  In
addition,  the  coverage  claimed  in  a  patent  application  can  be  significantly  reduced  before  the  patent  is  issued,  and  its  scope  can  be  reinterpreted  after
issuance. Consequently, we do not know whether any of our products or drug candidates will be protectable or remain protected by enforceable patents. We
cannot predict whether the patent applications we are currently pursuing will issue as patents in any particular jurisdiction or whether the claims of our
issued patents will provide sufficient proprietary protection from competitors. Any patents that we hold may be challenged, circumvented or invalidated by
third parties. If third parties prepare and file patent applications in the U.S. that also claim technology or therapeutics to which we have rights, we may have
to  participate  in  interference  proceedings  in  the  U.S.  Patent  and  Trademark  Office  (USPTO)  to  determine  priority  of  invention,  which  would  result  in
substantial costs to us even if the eventual outcome is favorable to us.

The term of individual patents depends upon the legal term of the patents in countries in which they are obtained. In most countries, including the U.S., the
patent term is generally 20 years from the earliest date of filing a non-provisional patent application in the applicable country. In the U.S., a patent’s term
may, in certain cases, be lengthened by patent term adjustment, which compensates a patentee for administrative delays by the USPTO in examining and
granting  a  patent,  or  may  be  shortened  if  a  patent  is  terminally  disclaimed  over  a  commonly  owned  patent  or  a  patent  naming  a  common  inventor  and
having an earlier expiration date.

In  addition,  in  the  U.S.,  the  Hatch-Waxman  Act  permits  a  patent  term  extension  of  up  to  five  years  beyond  the  expiration  of  a  U.S.  patent  as  partial
compensation for the patent term lost during the FDA regulatory review process occurring while the patent is in force. A patent extension cannot extend the
remaining term of a patent beyond a total of 14 years from the date of product approval, and only one patent applicable to each regulatory review period
may  be  extended  and  only  those  claims  covering  the  approved  drug,  a  method  for  using  it  or  a  method  for  manufacturing  it  may  be  extended.  Similar
provisions are available in the European Union and certain other foreign jurisdictions to extend the term of a patent that covers an approved drug.

We may rely, in some circumstances, on trade secrets to protect our technology. Although we take steps to protect our proprietary information and trade
secrets,  including  through  contractual  means  with  our  employees  and  consultants,  third  parties  may  independently  develop  substantially  equivalent
proprietary information and techniques or otherwise gain access to our trade secrets or disclose our technology. Thus, we may not be able to meaningfully
protect our trade secrets. It is our policy to require our employees, consultants, outside scientific collaboration partners, sponsored researchers and other
advisors to execute confidentiality agreements upon the commencement of employment or consulting relationships with us. These agreements provide that
all confidential information concerning the business or financial affairs developed or made known to the individual during the course of the individual’s
relationship with us is to be kept confidential and not disclosed to third parties except in specific circumstances. In the case of employees, the agreements
provide  that  all  inventions  conceived  by  the  individual,  and  which  are  related  to  our  current  or  planned  business  or  research  and  development  or  made
during the normal working hours, on our premises or using our equipment or proprietary information, are our exclusive property.

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Tenapanor Patents

Our  tenapanor  patent  portfolio  includes  five  issued  U.S.  patents,  three  issued  patents  in  each  of  Israel  and  Mexico,  two  issued  patents  in  each  of  the
European Patent Organization, Japan, Korea, and Hong Kong and one issued patent in each of the following territories: Australia, Brazil, India, and China.
These  issued  patents  cover  the  composition  and  certain  methods  of  using  tenapanor,  are  wholly  owned  by  us,  and  are  predicted,  without  extension  or
adjustment, to expire in December 2029. The term of U.S. patent no. 8,541,448, which claims the composition of matter of tenapanor, was extended under
the Hatch-Waxman Act to August 1, 2033. The portfolio further includes patents covering the use of tenapanor for controlling serum phosphorus that are
wholly owned by us and have been issued in the U.S., Europe, Japan, China, Australia, Gulf Co-op countries, Hong Kong, Israel, Korea, Macao, Mexico,
New Zealand, Russia, South Africa and Taiwan and are pending in other countries. These patents are predicted, without extension or adjustment, to expire
in April 2034.

Additional U.S. and international patent applications are pending covering additional methods of treatment with tenapanor, and composition of matter and
methods of using compounds that we believe may be follow on compounds to tenapanor.

Other Program Patents

We have patent applications pending in the U.S. and internationally that cover the compositions and methods of using compounds in our RDX013 program.

Manufacturing

To date, we have relied upon third-party contract manufacturing organizations (CMOs) to manufacture both the active pharmaceutical ingredient and final
drug product dosage forms of our commercial products, as well as our clinical trial material, and we expect that we will continue to rely upon CMOs for the
manufacture of commercial product for IBSRELA, commercial product for XPHOZAH, and clinical trial materials. Our license agreements with Knight
and Fosun Pharma require us to supply final drug product dosage forms of tenapanor for their use in the development and commercialization of tenapanor
in each of their respective territories. We are further obligated to supply active pharmaceutical ingredient to Kyowa Kirin to support their development and
commercialization of tenapanor in Japan. We expect that we will continue to use CMOs to satisfy our supply obligations to our collaboration partners.

Government Regulation

The  FDA  and  comparable  regulatory  authorities  in  state  and  local  jurisdictions  and  in  other  countries  impose  substantial  and  burdensome  requirements
upon companies involved in the clinical development, manufacture, marketing and distribution of drugs. These agencies and other federal, state and local
entities regulate research and development activities and the testing, manufacture, quality control, safety, effectiveness, labeling, storage, record keeping,
approval, advertising and promotion, distribution, post-approval monitoring and reporting, sampling, and export and import of our product candidates.

In the U.S., the FDA regulates drug products under the Federal Food, Drug, and Cosmetic Act (FFDCA) and the FDA’s implementing regulations. If we
fail to comply with applicable U.S. FDA or other requirements at any time during the drug development process, the approval process or after approval, we
may become subject to administrative or judicial sanctions. These sanctions could include the U.S. FDA’s refusal to approve pending applications, license
suspension or revocation, withdrawal of an approval, warning or untitled letters, product recalls, product seizures, total or partial suspension of production
or distribution, injunctions, fines, civil penalties or criminal prosecution. Any U.S. FDA enforcement action could have a material adverse effect on us.
U.S. FDA approval is required before any new unapproved drug or dosage form, including a new use of a previously approved drug, can be marketed in the
U.S.

The process required by the U.S. FDA before a drug may be marketed in the U.S. generally involves:

•

•

•

completion of extensive preclinical laboratory tests, preclinical animal studies and formulation studies, some performed in accordance with the
U.S. FDA’s current Good Laboratory Practice (GLP) regulations;

submission to the U.S. FDA of an Investigational New Drug (IND) application which must become effective before human clinical trials in the
U.S. may begin;

approval by an independent institutional review board, (IRB) or ethics committee at each clinical trial site before each trial may be initiated;

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•

•

•

•

performance of adequate and well-controlled human clinical trials in accordance with Good Clinical Practice (GCP) regulations to establish the
safety and efficacy of the drug candidate for each proposed indication;

submission to the U.S. FDA of an NDA;

satisfactory completion of a U.S. FDA inspection of the manufacturing facility or facilities at which the drug is produced to assess compliance
with current Good Manufacturing Practice (cGMP) regulations;

satisfactory completion of a potential review by an U.S. FDA advisory committee, if applicable; and

• U.S. FDA review and approval of the NDA prior to any commercial marketing, sale or commercial shipment of the drug.

The  preclinical  and  clinical  testing  and  approval  process  requires  substantial  time,  effort  and  financial  resources,  and  we  cannot  be  certain  that  any
approvals for any product candidates that we may seek to advance will be granted on a timely basis, if at all. Nonclinical tests include laboratory evaluation
of  product  chemistry,  formulation,  stability  and  toxicity,  as  well  as  animal  studies  to  assess  the  characteristics  and  potential  safety  and  efficacy  of  the
product.  The  results  of  preclinical  tests,  together  with  manufacturing  information,  analytical  data  and  a  proposed  clinical  trial  protocol  and  other
information,  are  submitted  as  part  of  an  IND  to  the  U.S.  FDA.  Additional  preclinical  testing  may  continue  even  after  the  IND  is  submitted.  The  IND
automatically becomes effective 30 days after receipt by the U.S. FDA, unless the U.S. FDA, within the 30-day period, raises concerns or questions relating
to the IND and places the clinical trial on a clinical hold, including concerns that human research subjects will be exposed to unreasonable health risks. In
such a case, the IND sponsor and the U.S. FDA must resolve any outstanding concerns before the clinical trial can begin. A separate submission to an
existing IND must also be made for each successive clinical trial conducted during product development.

Clinical trials involve the administration of the investigational drug to human subjects under the supervision of qualified investigators. Clinical trials are
conducted  under  protocols  detailing,  among  other  things,  the  objectives  of  the  clinical  trial,  the  parameters  to  be  used  in  monitoring  safety  and  the
effectiveness criteria to be used. Each protocol must be submitted to the U.S. FDA as part of the IND.

An independent IRB or ethics committee for each medical center proposing to conduct a clinical trial must also review and approve a plan for any clinical
trial before it can begin at that center and the IRB must monitor the clinical trial until it is completed. The U.S. FDA, the IRB, or the sponsor may suspend
or discontinue a clinical trial at any time on various grounds, including a finding that the subjects are being exposed to an unacceptable health risk. Clinical
testing also must satisfy extensive GCP requirements, including the requirements for informed consent.

All clinical research performed in the U.S. in support of an NDA must be submitted in advance by the U.S. FDA under the IND regulations and procedures
described above. However, a sponsor who wishes to conduct a clinical trial outside the U.S. may, but need not, obtain U.S. FDA authorization to conduct
the clinical trial under an IND. If a foreign clinical trial is not conducted under an IND, the sponsor may submit data from the clinical trial to the U.S. FDA
in support of an NDA so long as the clinical trial is conducted in compliance with GCP and if the U.S. FDA is able to validate the data from the study
through  an  onsite  inspection,  if  necessary.  GCP  includes  review  and  approval  by  an  independent  ethics  committee,  such  as  an  IRB,  and  obtaining  and
documenting the freely given informed consent of each subject before study initiation. If the applicant seeks approval of an NDA solely on the basis of
foreign  data,  the  U.S.  FDA  will  only  accept  such  data  if  they  are  applicable  to  the  U.S.  population  and  U.S.  medical  practice,  the  studies  have  been
performed by clinical investigators of recognized competence, and the data may be considered valid without the need for an on-site inspection by the U.S.
FDA, or if the U.S. FDA considers such an inspection to be necessary, the U.S. FDA is able to validate the data through an on-site inspection or through
other appropriate means.

Clinical Trials

The  clinical  investigation  of  a  new  drug  is  typically  conducted  in  three  or  four  phases,  which  may  overlap  or  be  combined,  and  generally  proceed  as
follows.

•

Phase 1: Clinical trials are initially conducted in a limited population of subjects to test the drug candidate for safety, dose tolerance, absorption,
metabolism, distribution and excretion in healthy humans or, on occasion, in patients with severe problems or life-threatening diseases to gain an
early indication of its effectiveness.

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•

•

•

Phase  2:  Clinical  trials  are  generally  conducted  in  a  limited  patient  population  to  evaluate  dosage  tolerance  and  appropriate  dosage,  identify
possible adverse effects and safety risks, and evaluate preliminarily the efficacy of the drug for specific targeted indications in patients with the
disease or condition under study.

Phase 3: Clinical trials are typically conducted when Phase 2 clinical trials demonstrate that a dose range of the product candidate is effective and
has  an  acceptable  safety  profile.  Phase  3  clinical  trials  are  commonly  referred  to  as  “pivotal”  studies,  which  typically  denotes  a  study  which
presents the data that the U.S. FDA or other relevant regulatory agency will use to determine whether or not to approve a drug. Phase 3 clinical
trials are generally undertaken with large numbers of patients, such as groups of several hundred to several thousand, to further evaluate dosage, to
provide  substantial  evidence  of  clinical  efficacy  and  to  further  test  for  safety  in  an  expanded  and  diverse  patient  population  at  multiple,
geographically dispersed clinical trial sites.

Phase  4:  In  some  cases,  the  U.S.  FDA  may  condition  approval  of  an  NDA  for  a  product  candidate  on  the  sponsor’s  agreement  to  conduct
additional clinical trials after NDA approval. In other cases, a sponsor may voluntarily conduct additional clinical trials post approval to gain more
information about the drug. Such post approval trials are typically referred to as Phase 4 clinical trials.

Concurrent with clinical trials, companies usually complete additional nonclinical studies and must also develop additional information about the chemistry
and physical characteristics of the drug and finalize a process for manufacturing the drug in commercial quantities in accordance with GMP requirements.
The manufacturing process must be capable of consistently producing quality batches of the drug candidate and, among other things, the manufacturer must
develop methods for testing the identity, strength, quality and purity of the final drug product. Additionally, appropriate packaging must be selected and
tested, and stability studies must be conducted to demonstrate that the drug candidate does not undergo unacceptable deterioration over its shelf life.

The U.S. FDA, the IRB or the clinical trial sponsor may suspend or terminate a clinical trial at any time on various grounds, including a finding that the
research subjects are being exposed to an unacceptable health risk.

Additionally, some clinical trials are overseen by an independent group of qualified experts organized by the clinical trial sponsor, known as a data safety
monitoring board or committee. This group provides authorization for whether or not a trial may move forward at designated check points based on access
to certain data from the study.

We may also suspend or terminate a clinical trial based on evolving business objectives and/or competitive climate.

New Drug Applications

The  results  of  preclinical  studies  and  of  the  clinical  trials,  together  with  other  detailed  information,  including  extensive  manufacturing  information  and
information on the composition of the drug, are submitted to the U.S. FDA in the form of an NDA requesting approval to market the drug for one or more
specified indications. The U.S. FDA reviews an NDA to determine, among other things, whether a drug is safe and effective for its intended use.

Under the Prescription Drug User Fee Act, the U.S. FDA has a goal of responding to standard review NDAs for new molecular entities within ten months
after the 60-day filing review period, or six months after the 60-day filing review period for priority review NDAs. For non-new molecular entities, the
U.S.  FDA  has  a  goal  of  responding  within  ten  months  of  receipt  of  standard  review  NDAs  and  six  months  of  receipt  for  priority  review  NDAs.  These
timeframes are often extended by U.S. FDA requests for additional information or clarification. The U.S. FDA may refer the application to an advisory
committee  for  review,  evaluation  and  recommendation  as  to  whether  the  application  should  be  approved.  The  U.S.  FDA  is  not  bound  by  the
recommendation of an advisory committee, but it generally follows such recommendations.

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After the U.S. FDA evaluates the NDA and conducts inspections of manufacturing facilities where the drug product and/or its API will be produced, if
deemed necessary, it may issue an approval letter or a Complete Response Letter. An approval letter authorizes commercial marketing of the drug with
specific prescribing information for specific indications. A Complete Response Letter indicates that the review cycle of the application is complete, and the
application is not ready for approval. A Complete Response Letter may require additional clinical data and/or an additional Phase 3 clinical trial(s), and/or
other  significant,  expensive  and  time-consuming  requirements  related  to  clinical  trials,  preclinical  studies  or  manufacturing.  Even  if  such  additional
information is submitted, the U.S. FDA may ultimately decide that the NDA does not satisfy the criteria for approval. The U.S. FDA could also approve the
NDA with a Risk Evaluation and Mitigation Strategy (REMS) if it is determined that a REMS is necessary to ensure that the drug’s benefits outweigh its
risks  and  a  REMS  to  mitigate  risks,  which  could  include  medication  guides,  physician  communication  plans,  or  elements  to  assure  safe  use,  such  as
restricted distribution methods, patient registries and other risk minimization tools. The U.S. FDA also may condition approval on, among other things,
changes to proposed labeling, development of adequate controls and specifications, or a commitment to conduct one or more post-market studies or clinical
trials. Such post-market testing may include Phase 4 clinical trials and surveillance to further assess and monitor the product’s safety and effectiveness after
commercialization. The U.S. FDA has the authority to prevent or limit further marketing of a drug based on the results of these post-market programs.
Once the U.S. FDA approves an NDA, or supplement thereto, the U.S. FDA may withdraw the approval if ongoing regulatory requirements are not met or
if safety problems are identified after the drug reaches the market.

Drugs may be marketed only for the U.S. FDA approved indications and in accordance with the provisions of the approved labeling. Further, if there are
any modifications to the drug, including changes in indications, labeling, or manufacturing processes or facilities, the applicant may be required to submit
and  obtain  U.S.  FDA  approval  of  a  new  NDA  or  NDA  supplement,  which  may  require  the  applicant  to  develop  additional  data  or  conduct  additional
preclinical studies and clinical trials.

The testing and approval processes require substantial time, effort and financial resources, and each may take several years to complete. The U.S. FDA may
not grant approval on a timely basis, or at all. Even if we believe a clinical trial has demonstrated safety and efficacy of one of our drug candidates for the
proposed indication, the results may not be satisfactory to the U.S. FDA. Nonclinical and clinical data may be interpreted by the U.S. FDA in different
ways,  which  could  delay,  limit  or  prevent  regulatory  approval.  We  may  encounter  difficulties  or  unanticipated  costs  in  our  efforts  to  secure  necessary
governmental approvals which could delay or preclude us from marketing drugs. The U.S. FDA may limit the indications for use or place other conditions
on any approvals that could restrict the commercial application of the drugs. After approval, certain changes to the approved drug, such as adding new
indications, manufacturing changes, or additional labeling claims are subject to further U.S. FDA review and approval. Depending on the nature of the
change proposed, an NDA supplement must be filed and approved before the change may be implemented.

Other Regulatory Requirements

Any drugs manufactured or distributed by us or our collaboration partners pursuant to U.S. FDA approvals would be subject to continuing regulation by the
U.S.  FDA,  including  recordkeeping  requirements  and  reporting  of  adverse  experiences  associated  with  the  drug.  Drug  manufacturers  and  their
subcontractors  are  required  to  register  their  establishments  with  the  U.S.  FDA  and  certain  state  agencies  and  are  subject  to  periodic  announced  and
unannounced inspections by the U.S. FDA and certain state agencies for compliance with ongoing regulatory requirements, including cGMP, which impose
certain  procedural  and  documentation  requirements  upon  us  and  our  third-party  manufacturers.  Failure  to  comply  with  the  statutory  and  regulatory
requirements can subject a manufacturer to possible legal or regulatory action, such as warning or untitled letters, suspension of manufacturing, seizure of
product, injunctive action or possible civil penalties. We cannot be certain that we or our present or future third-party manufacturers or suppliers will be
able to comply with the cGMP regulations and other ongoing U.S. FDA regulatory requirements. If we or our present or future third-party manufacturers or
suppliers are not able to comply with these requirements, the U.S. FDA may, among other things, halt our clinical trials, require us to recall a drug from
distribution or withdraw approval of the NDA for that drug.

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The  U.S.  FDA  closely  regulates  the  post-approval  marketing  and  promotion  of  drugs,  including  standards  and  regulations  for  direct-to-consumer
advertising, off-label promotion, industry-sponsored scientific and educational activities and promotional activities involving the Internet. A company can
make only those claims relating to safety and efficacy that are in the final label or consistent with the final label. Failure to comply with these requirements
can result in, among other things, adverse publicity, warning or untitled letters, corrective advertising and potential civil and criminal penalties. Physicians
may prescribe legally available drugs for uses that are not described in the product’s labeling and that differ from those tested by us and approved by the
U.S.  FDA.  Such  off-label  uses  are  common  across  medical  specialties.  Physicians  may  believe  that  such  off-label  uses  are  the  best  treatment  for  many
patients in varied circumstances. The U.S. FDA does not regulate the behavior of physicians in their choice of treatments. The U.S. FDA does, however,
impose stringent restrictions on manufacturers’ communications regarding off-label use.

Hatch-Waxman Act

Under  the  Price  Competition  and  Patent  Term  Restoration  Act,  or  Hatch-Waxman  Act,  Section  505  of  the  FFDCA  describes  three  types  of  marketing
applications that may be submitted to the U.S. FDA to request marketing authorization for a new drug. A Section 505(b)(1) NDA is an application that
contains full reports of investigations of safety and efficacy. A Section 505(b)(2) NDA is an application that contains full reports of investigations of safety
and efficacy but where at least some of the information required for approval comes from investigations that were not conducted by or for the applicant and
for which the applicant has not obtained a right of reference or use from the person by or for whom the investigations were conducted. This regulatory
pathway enables the applicant to rely, in part, on the U.S. FDA’s prior findings of safety and efficacy for an existing product, or published literature, in
support  of  its  application.  Section  505(j)  establishes  an  abbreviated  approval  process  for  a  generic  version  of  approved  drug  products  through  the
submission  of  an  Abbreviated  New  Drug  Application  (ANDA).  An  ANDA  provides  for  marketing  of  a  generic  drug  product  that  has  the  same  active
ingredients,  dosage  form,  strength,  route  of  administration,  labeling,  performance  characteristics  and  intended  use,  among  other  things,  to  a  previously
approved product. ANDAs are termed “abbreviated” because they are generally not required to include nonclinical (animal) and clinical (human) data to
establish  safety  and  efficacy.  Instead,  generic  applicants  must  scientifically  demonstrate  that  their  product  is  bioequivalent  to,  or  performs  in  the  same
manner as, the innovator drug through in vitro, in vivo, or other testing. The generic version must deliver the same amount of active ingredients into a
subject’s bloodstream in the same amount of time as the innovator drug and can often be substituted by pharmacists under prescriptions written for the
reference listed drug. In seeking approval for a drug through an NDA, applicants are required to list with the U.S. FDA each patent with claims that cover
the applicant’s drug or a method of using the drug. Upon approval of a drug, each of the patents listed in the application for the drug is then published in the
U.S. FDA’s Approved Drug Products with Therapeutic Equivalence Evaluations, commonly known as the Orange Book. Drugs listed in the Orange Book
can, in turn, be cited by potential competitors in support of approval of an ANDA or 505(b)(2) NDA.

Upon submission of an ANDA or a 505(b)(2) NDA, an applicant must certify to the U.S. FDA that (1) no patent information on the drug product that is the
subject of the application has been submitted to the U.S. FDA; (2) such patent has expired; (3) the date on which such patent expires; or (4) such patent is
invalid or will not be infringed upon by the manufacture, use or sale of the drug product for which the application is submitted. Generally, the ANDA or
505(b)(2) NDA cannot be approved until all listed patents have expired, except where the ANDA or 505(b)(2) NDA applicant challenges a listed patent
through the last type of certification, also known as a Paragraph IV certification. If the applicant does not challenge the listed patents or indicates that it is
not seeking approval of a patented method of use, the ANDA or 505(b)(2) NDA application will not be approved until all of the listed patents claiming the
referenced product have expired.

If the ANDA or 505(b)(2) NDA applicant has provided a Paragraph IV certification to the U.S. FDA, the applicant must send notice of the Paragraph IV
certification to the NDA holder and patent owners once the application has been accepted for filing by the U.S. FDA. The NDA and patent holders may
then initiate a patent infringement lawsuit in response to the notice of the Paragraph IV certification. If the Paragraph IV certification is challenged by an
NDA holder or the patent owner(s), the U.S. FDA may not approve that application until the earlier of 30 months from the receipt of the notice of the
Paragraph IV certification, the expiration of the patent, when the infringement case concerning each such patent was favorably decided in the applicant’s
favor or settled, or such shorter or longer period as may be ordered by a court. This prohibition is generally referred to as the 30-month stay. In instances
where an ANDA or 505(b)(2) NDA applicant files a Paragraph IV certification, the NDA holder or patent owner(s) regularly take action to trigger the 30-
month stay, recognizing that the related patent litigation may take many months or years to resolve. Thus, approval of an ANDA or 505(b)(2) NDA could
be delayed for a significant period of time depending on the patent certification the applicant makes and the reference drug sponsor’s decision to initiate
patent litigation.

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The Hatch-Waxman Act establishes periods of regulatory exclusivity for certain approved drug products, during which the U.S. FDA cannot approve (or in
some cases accept) an ANDA or 505(b)(2) application that relies on the branded reference drug. For example, the holder of an NDA, including a 505(b)
(2) NDA, may obtain five years of exclusivity upon approval of a new drug containing a new chemical entity (NCE) that has not been previously approved
by the U.S. FDA. A drug is a new chemical entity if the U.S. FDA has not previously approved any other new drug containing the same active moiety,
which is the molecule or ion responsible for the therapeutic activity of the drug substance. During the exclusivity period, the U.S. FDA may not accept for
review an ANDA or a 505(b)(2) NDA submitted by another company that contains the previously approved active moiety. However, an ANDA or 505(b)
(2) NDA may be submitted after four years if it contains a Paragraph IV certification of patent invalidity or non-infringement.

The Hatch-Waxman Act also provides three years of marketing exclusivity to the holder of an NDA (including a 505(b)(2) NDA) for a particular condition
of approval, or change to a marketed product, such as a new formulation for a previously approved product, if one or more new clinical studies (other than
bioavailability or bioequivalence studies) was essential to the approval of the application and was conducted/sponsored by the applicant. This three-year
exclusivity period protects against U.S. FDA approval of ANDAs and 505(b)(2) NDAs for the specific condition of the new drug’s approval. As a general
matter,  the  three-year  exclusivity  does  not  prohibit  the  U.S.  FDA  from  approving  ANDAs  or  505(b)(2)  NDAs  for  generic  versions  of  the  original,
unmodified drug product. Five-year and three-year exclusivity will not delay the submission or approval of a full NDA; however, an applicant submitting a
full  NDA  would  be  required  to  conduct  or  obtain  a  right  of  reference  to  all  of  the  preclinical  studies  and  adequate  and  well-controlled  clinical  trials
necessary to demonstrate safety and efficacy.

Fraud and Abuse Laws

In  the  U.S.  the  research,  manufacturing,  distribution,  sale  and  promotion  of  drug  products  and  medical  devices  are  potentially  subject  to  regulation  by
various federal, state and local authorities in addition to the U.S. FDA, including the Centers for Medicare & Medicaid Services (CMS) other divisions of
the U.S. Department of Health and Human Services (e.g., the Office of Inspector General), the U.S. Department of Justice, state Attorneys General, and
other state and local government agencies. These laws include but are not limited to, the Anti-Kickback Statute, the federal False Claims Act, the federal
Physician Payments Sunshine Act, and other state and federal laws and regulations.

The Anti-Kickback Statute makes it illegal for any person, including a prescription drug manufacturer (or a party acting on its behalf) to knowingly and
willfully solicit, receive, offer, or pay any remuneration that is intended to induce the referral of business, including the purchase, order, or prescription of a
particular  drug,  for  which  payment  may  be  made  under  a  federal  healthcare  program,  such  as  Medicare  or  Medicaid.  The  term  remuneration  has  been
interpreted broadly to include anything of value. There are a number of statutory exceptions and regulatory safe harbors protecting some common activities
from prosecution. The exceptions and safe harbors are drawn narrowly and practices that involve remuneration that may be alleged to be intended to induce
prescribing,  purchasing  or  recommending  may  be  subject  to  scrutiny  if  they  do  not  qualify  for  an  exception  or  safe  harbor.  Failure  to  meet  all  of  the
requirements  of  a  particular  applicable  statutory  exception  or  regulatory  safe  harbor  does  not  make  the  conduct  per  se  illegal  under  the  federal  Anti-
Kickback Statute. Instead, the legality of the arrangement will be evaluated on a case-by-case basis based on a cumulative review of all of its facts and
circumstances.  Additionally,  a  person  or  entity  does  not  need  to  have  actual  knowledge  of  the  statute  or  specific  intent  to  violate  it  in  order  to  have
committed a violation.

The  federal  False  Claims  Act  prohibits  anyone  from  knowingly  presenting,  or  causing  to  be  presented,  for  payment  to  federal  programs  (including
Medicare and Medicaid) claims for items or services, including drugs, that are false or fraudulent, claims for items or services not provided as claimed, or
claims for medically unnecessary items or services. Although we would not submit claims directly to payors, manufacturers can be held liable under these
laws  if  they  are  deemed  to  “cause”  the  submission  of  false  or  fraudulent  claims  by,  for  example,  providing  inaccurate  billing  or  coding  information  to
customers or promoting a product off-label. In addition, our activities relating to the reporting of wholesaler or estimated retail prices for our products, the
reporting  of  prices  used  to  calculate  Medicaid  rebate  information  and  other  information  affecting  federal,  state,  and  third-party  reimbursement  for  our
products, and the sale and marketing of our products, are subject to scrutiny under this law. Moreover, the government may assert that a claim including
items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the False Claims Act.
If the government were to allege that we were, or convict us of, violating these false claims laws, we could be subject to a substantial fine and may suffer a
decline in our stock price. In addition, private individuals have the ability to bring actions under the federal False Claims Act.

The civil monetary penalties statute imposes penalties against any person or entity who, among other things, is determined to have presented or caused to
be presented a claim to a federal health program that the person knows or should know is for an item or service that was not provided as claimed or is false
or fraudulent.

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The federal Health Insurance Portability and Accountability Act of 1996, or HIPAA, created additional federal criminal statutes that prohibit knowingly
and willfully executing, or attempting to execute, a scheme to defraud any healthcare benefit program or obtain, by means of false or fraudulent pretenses,
representations  or  promises,  any  of  the  money  or  property  owned  by,  or  under  the  custody  or  control  of,  any  healthcare  benefit  program,  regardless  of
whether the payor is public or private, knowingly and willfully embezzling or stealing from a health care benefit program, willfully obstructing a criminal
investigation of a health care offense and knowingly and willfully falsifying, concealing or covering up by any trick or device a material fact or making any
materially false statements in connection with the delivery of, or payment for, healthcare benefits, items or services relating to healthcare matters. Similar
to the federal Anti-Kickback Statute, a person or entity does not need to have actual knowledge of the statute, or the specific intent to violate it, to have
committed a violation.

In addition to the laws described above, the Physician Payments Sunshine Act requires certain drug manufacturers to report payments and other transfer of
value made to physicians (defined to include doctors, dentists, optometrists, podiatrists and chiropractors) certain non-physician practitioners (physician
assistants, nurse practitioners, clinical nurse specialists, certified nurse anesthetists, anesthesiologist assistants and certified nurse midwives) and teaching
hospitals, as well as ownership and investment interests held by physicians and their immediate family members. Failure to submit required information
may  result  in  significant  civil  monetary  penalties,  and  additional  penalties  for  knowing  failures,  for  all  payments,  transfers  of  value  or  ownership  or
investment interests that are not timely, accurately and completely reported in an annual submission. Manufacturers must submit reports by the 90th day of
each subsequent calendar year.

Many  states  have  also  adopted  laws  similar  to  the  federal  laws  discussed  above.  Some  of  these  state  prohibitions  apply  to  the  referral  of  patients  for
healthcare services reimbursed by any insurer, not just federal healthcare programs such as Medicare and Medicaid. There has also been a recent trend of
increased  regulation  of  payments  made  to  physicians  and  other  healthcare  providers.  Certain  states  mandate  implementation  of  compliance  programs,
impose restrictions on drug manufacturers’ marketing practices and/or require the tracking and reporting of pricing and marketing information as well as
gifts, compensation and other remuneration to physicians. Many of these laws contain ambiguities as to what is required to comply with such laws, which
may affect our sales, marketing, and other promotional activities by imposing administrative and compliance burdens on us. In addition, given the lack of
clarity  with  respect  to  these  laws  and  their  implementation,  our  reporting  actions  could  be  subject  to  the  penalty  provisions  of  the  pertinent  state  and
perhaps federal authorities.

Violations of any of such laws or any other governmental regulations that apply may result in penalties, including, without limitation, administrative, civil
and criminal penalties, damages, fines, disgorgement, the curtailment or restructuring of operations, reporting obligations and integrity oversight, exclusion
from participation in federal and state healthcare programs and imprisonment.

Third-Party Coverage and Reimbursement

Sales of pharmaceutical products depend in significant part on the availability of coverage and adequate reimbursement by third-party payors, such as state
and  federal  governments,  including  Medicare  and  Medicaid,  and  commercial  managed  care  providers.  In  the  U.S.,  no  uniform  policy  of  coverage  and
reimbursement for drug products exists among third-party payors. Accordingly, decisions regarding the extent of coverage and amount of reimbursement to
be provided for our product candidates are made on a payor by payor basis. As a result, the coverage determination process is often a time-consuming and
costly process that will require us to provide scientific and clinical support for the use of our product candidates to each payor separately, with no assurance
that  coverage  and  adequate  reimbursement  will  be  obtained.  Third-party  payors  may  limit  coverage  to  specific  drug  products  on  an  approved  list,  or
formulary,  which  might  not  include  all  of  the  U.S.  FDA-approved  drugs  for  a  particular  indication.  A  decision  by  a  third-party  payor  not  to  cover  our
product  candidates  could  reduce  physician  utilization  of  our  products  once  approved  and  have  a  material  adverse  effect  on  our  future  sales,  results  of
operations and financial condition. Moreover, a payor’s decision to provide coverage for a drug product does not imply that an adequate reimbursement rate
will be approved. Adequate third-party reimbursement may not be available to enable us to maintain price levels sufficient to realize an appropriate return
on our investment in product development.

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There  is  increased  uncertainty  related  to  insurance  coverage  and  reimbursement  for  certain  drugs,  like  XPHOZAH,  which  is  marketed  to  reduce  serum
phosphorus in adults with CKD on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of
any dose of phosphate binder therapy. In January 2011, CMS implemented a new prospective payment system for dialysis treatment. Under the End Stage
Renal Disease (ESRD) prospective payment system, CMS generally makes a single bundled payment to the dialysis facility for each dialysis treatment that
covers all items and services routinely required for dialysis treatments furnished to Medicare beneficiaries in Medicare-certified ESRD facilities or at their
home, including the cost of certain routine drugs. The inclusion of oral medications without injectable or intravenous equivalents in the bundled payment
was initially delayed until January 1, 2014 and through several subsequent legislative actions was delayed until January 1, 2025. As a result, absent further
legislation or regulation on this matter, beginning in 2025, oral ESRD-related drugs without injectable or intravenous equivalents may be included in the
ESRD bundle and separate Medicare payment for these drugs will no longer be available, as is the case today under Medicare Part D. While it is too early
to project the full impact that bundling may have on XPHOZAH and our business should XPHOZAH be brought into the bundle in 2025, or at any time,
we may be unable to sell XPHOZAH to dialysis providers on a profitable basis.

Healthcare Reform

In March 2010, Congress passed the Patient Protection and Affordable Care Act, a healthcare reform measure (ACA). The ACA was signed into law and
substantially changed the way healthcare is financed by both governmental and private insurers, and significantly impacted the pharmaceutical industry.

The ACA contained a number of provisions, including those governing enrollment in federal healthcare programs, reimbursement changes and fraud and
abuse  measures,  which  have  impacted  existing  government  healthcare  programs  and  have  resulted  in  the  development  of  new  programs,  including
Medicare payment for performance initiatives and improvements to the physician quality reporting system and feedback program.

Additionally, the ACA:

•

•

•

•

•

•

increased  the  minimum  level  of  Medicaid  rebates  payable  by  manufacturers  of  brand-name  drugs  from  15.1%  to  23.1%  of  the  average
manufacturer price;

required collection of rebates for drugs paid by Medicaid managed care organizations;

expanded eligibility criteria for Medicaid programs by, among other things, allowing states to offer Medicaid coverage to additional individuals
and by adding new mandatory eligibility categories for certain individuals with income at or below 133% of the federal poverty level, thereby
potentially increasing a manufacturer’s Medicaid rebate liability;

expanded access to commercial health insurance coverage through new state-based health insurance marketplaces, or exchanges;

required manufacturers to participate in a coverage gap discount program, under which they must now agree to offer 70% point-of-sale discounts
off negotiated prices of applicable brand drugs to eligible beneficiaries during their coverage gap period, as a condition for the manufacturer’s
outpatient drugs to be covered under Medicare Part D; and

imposed  a  non-deductible  annual  fee  on  pharmaceutical  manufacturers  or  importers  who  sell  “branded  prescription  drugs”  to  specified  federal
government programs.

Since its enactment, there have been judicial, executive and Congressional challenges to certain aspects of the ACA. On June 17, 2021, the U.S. Supreme
Court dismissed a challenge on procedural grounds that argued the ACA is unconstitutional in its entirety because the “individual mandate” was repealed
by Congress. Thus, the ACA will remain in effect in its current form. Further, prior to the U.S. Supreme Court ruling, President Biden issued an executive
order that initiated a special enrollment period for purposes of obtaining health insurance coverage through the ACA marketplace from February 15, 2021
through August 15, 2021. The executive order instructed certain governmental agencies to review and reconsider their existing policies and rules that limit
access  to  healthcare,  including  among  others,  reexamining  Medicaid  demonstration  projects  and  waiver  programs  that  include  work  requirements,  and
policies that create unnecessary barriers to obtaining access to health insurance coverage through Medicaid or the ACA.

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In addition, other legislative changes have been proposed and adopted in the U.S. since the ACA was enacted. For example, in August 2011, the Budget
Control Act of 2011, among other things, included aggregate reductions to Medicare payments to providers, which went into effect on April 1, 2013, and,
due to subsequent legislative amendments, will remain in effect through 2032, with the exception of a temporary suspension from May 1, 2020 through
March 31, 2022, unless additional Congressional action is taken. In January 2013, the American Taxpayer Relief Act, among other things, further reduced
Medicare payments to several providers, including hospitals, imaging centers and cancer treatment centers, and increased the statute of limitations period
for the government to recover overpayments to providers from three to five years. More recently, on March 11, 2021, President Biden signed the American
Rescue Plan Act of 2021 into law, which eliminates the statutory Medicaid drug rebate cap beginning January 1, 2024. The rebate was previously capped at
100% of a drug's average manufacturer price.

Recently, there has also been heightened governmental scrutiny over the manner in which drug manufacturers set prices for their marketed products, which
has resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review the
relationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug products. Most
recently, on August 16, 2022, the Inflation Reduction Act of 2022 (the IRA) was signed into law. Among other things, the IRA requires manufacturers of
certain drugs to engage in price negotiations with Medicare (beginning in 2026), imposes rebates under Medicare Part B and Medicare Part D to penalize
price  increases  that  outpace  inflation  (first  due  in  2023),  and  replaces  the  Part  D  coverage  gap  discount  program  with  a  new  discounting  program
(beginning in 2025). Under the IRA, small molecule drugs and biologics first become eligible for price negotiation seven and eleven years, respectively,
after  FDA  approval.  The  IRA  permits  the  Secretary  of  the  Department  of  Health  and  Human  Services  (HHS)  to  implement  many  of  these  provisions
through guidance, as opposed to regulation, for the initial years. On August 29, 2023, HHS announced the list of the first ten drugs that will be subject to
price negotiations.HHS has issued and will continue to issue guidance implementing the IRA, although the Medicare drug price negotiation program is
currently  subject  to  legal  challenges.  While  the  impact  of  the  IRA  on  the  pharmaceutical  industry  cannot  yet  be  fully  determined,  it  is  likely  to  be
significant.  Additionally,  individual  states  have  also  become  increasingly  active  in  passing  legislation  and  implementing  regulations  designed  to  control
pharmaceutical product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access, and to encourage
importation from other countries and bulk purchasing. These new laws and the regulations and policies implementing them, as well as other healthcare
reform measures that may be adopted in the future, may have a material adverse effect on our industry generally and on our ability to successfully develop
and commercialize our products.

Government Price Reporting

Medicaid is a joint federal and state program for low-income and disabled beneficiaries. Medicare is a federal program covering individuals age 65 and
over as well as those with certain disabilities. As a condition of having federal funds being made available for our covered drugs under Medicaid, we have
enrolled in the Medicaid Drug Rebate Program (MDRP), which requires us to pay a rebate to state Medicaid programs for each unit of our covered drugs
dispensed to a Medicaid beneficiary and paid for by a state Medicaid program. Medicaid drug rebates are based on pricing data that we must report on a
monthly and quarterly basis to the U.S. Centers for Medicare & Medicaid Services (CMS), the federal agency that administers the MDRP and Medicare
programs. For the MDRP, these data include the average manufacturer price (AMP) and the best price (BP) for each drug. If we become aware that our
MDRP price reporting submission for a prior period was incorrect or has changed as a result of recalculation of the pricing data, we must resubmit the
corrected  data  for  up  to  three  years  after  those  data  originally  were  due.  Manufacturers  who  fail  to  provide  information  timely  or  are  found  to  have
knowingly submitted false information to the government may be subject to civil monetary penalties and other sanctions, including termination from the
MDRP.

Federal law requires that a manufacturer that participates in the MDRP also participate in the Public Health Service’s 340B drug pricing program (340B
program) in order for federal funds to be available for the manufacturer’s drugs under Medicaid and Medicare Part B. We participate in the 340B program,
which is administered by the Health Resources and Services Administration (HRSA), and requires us to charge statutorily defined covered entities no more
than the 340B “ceiling price” for our covered outpatient drugs used in an outpatient setting. These 340B covered entities include a variety of community
health clinics and other entities that receive health services grants from the Public Health Service, as well as hospitals that serve a disproportionate share of
low-income  patients.  The  340B  ceiling  price  is  calculated  using  a  statutory  formula,  which  is  based  on  the  AMP  and  rebate  amount  for  the  covered
outpatient drug as calculated under the MDRP. In general, products subject to Medicaid price reporting and rebate liability are also subject to the 340B
ceiling price calculation and discount requirement. We must report 340B ceiling prices to HRSA on a quarterly basis, and HRSA publishes them to 340B
covered  entities.  HRSA  has  finalized  regulations  regarding  the  calculation  of  the  340B  ceiling  price  and  the  imposition  of  civil  monetary  penalties  on
manufacturers  that  knowingly  and  intentionally  overcharge  covered  entities  for  340B-eligible  drugs.  HRSA  has  also  finalized  an  administrative  dispute
resolution process through which 340B covered entities may pursue claims against participating

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manufacturers for overcharges, and through which manufacturers may pursue claims against 340B covered entities for engaging in unlawful diversion or
duplicate discounting of 340B drugs.

In  order  to  be  eligible  to  have  drug  products  paid  for  with  federal  funds  under  Medicaid  and  purchased  by  certain  federal  agencies  and  grantees,
manufacturers must also participate in the U.S. Department of Veterans Affairs (VA) Federal Supply Schedule (FSS) pricing program. Under the VA/FSS
program,  manufacturers  must  report  the  Non-Federal  Average  Manufacturer  Price  (Non-FAMP)  for  their  covered  drugs  to  the  VA  and  charge  certain
federal agencies no more than the Federal Ceiling Price, which is calculated based on Non-FAMP using a statutory formula. These four agencies are the
VA, the U.S. Department of Defense, the U.S. Coast Guard, and the U.S. Public Health Service (including the Indian Health Service). Manufacturers must
also pay rebates on products purchased by military personnel and dependents through the TRICARE retail pharmacy program. Manufacturers who fail to
provide timely information or are found to have knowingly submitted false information may be subject to civil monetary penalties.

Individual  states  continue  to  consider  and  have  enacted  legislation  to  limit  the  growth  of  healthcare  costs,  including  the  cost  of  prescription  drugs  and
combination products. A number of states have either implemented or are considering implementation of drug price transparency legislation. Requirements
under  such  laws  include  advance  notice  of  planned  price  increases,  reporting  price  increase  amounts  and  factors  considered  in  taking  such  increases,
wholesale  acquisition  cost  information  disclosure  to  prescribers,  purchasers,  and  state  agencies,  and  new  product  notice  and  reporting.  Such  legislation
could limit the price or payment for certain drugs, and a number of states are authorized to impose civil monetary penalties or pursue other enforcement
mechanisms  against  manufacturers  who  fail  to  comply  with  drug  price  transparency  requirements,  including  the  untimely,  inaccurate,  or  incomplete
reporting of drug pricing information.

Data Privacy and Security Laws

Numerous  state,  federal  and  foreign  laws,  including  consumer  protection  laws  and  regulations,  govern  the  collection,  dissemination,  use,  access  to,
confidentiality  and  security  of  personal  information,  including  health-related  information.  In  the  U.S.,  numerous  federal  and  state  laws  and  regulations,
including data breach notification laws, health information privacy and security laws that govern the collection, use, disclosure, and protection of health-
related and other personal information could apply to our operations or the operations of our partners. Further, certain foreign laws govern the privacy and
security of personal data, including health-related data. Failure to comply with these laws, where applicable, can result in the imposition of significant civil
and/or criminal penalties and private litigation. Privacy and security laws, regulations, and other obligations are constantly evolving, may conflict with each
other to complicate compliance efforts, and can result in investigations, proceedings, or actions that lead to significant civil and/or criminal penalties and
restrictions on data processing.

Other Regulations

We are also subject to numerous federal, state and local laws relating to such matters as safe working conditions, manufacturing practices, environmental
protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. We may incur significant costs to comply with such laws and
regulations now or in the future.

Human Capital

The  future  success  of  our  company  depends  on  our  ability  to  attract,  retain,  and  further  develop  top  talent.  Throughout  our  transition  to  a  commercial
organization and expansion of our workforce, we have remained steadfastly committed to our core values, including our goal to develop and maintain an
inclusive, diverse, and safe workplace with opportunities for our employees to grow and develop in their careers, supported by strong compensation and
benefits.

At December 31, 2023, we had 267 full-time employees, 55 of whom were engaged directly in development and manufacturing, and 212 in marketing,
sales and administrative activities. During 2023, our employee base increased by approximately 134, or 101%.

Inclusion and Diversity

Our culture is supported by an unwavering commitment to inclusion and diversity. As of December 31, 2023, approximately 57% of our workforce was
female;  50%  of  our  executive  leadership  team  was  female  and  54%  of  our  employees  in  managerial  roles  were  female.  As  of  December  31,  2023,
minorities represented approximately 31% of our workforce, and 45% of our employees in managerial roles were minorities. We strive to foster a culture
where mutual respect, inclusive behavior, and dignity are core to our individual expectations.

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We believe that our success will be significantly impacted by our ability to create and maintain a safe inclusive environment where everyone is empowered
to do their best work regardless of race, color, national origin, religion, sex, sexual orientation, gender identity and expression, age, or disability. We are
united  by  our  desire  to  serve  our  patients,  and  we  are  proud  financial  sponsors  of  the  California  Life  Sciences  Association  Racial  and  Social  Equity
Initiative, a first step in a unified effort for the life sciences industry in California to do more for the under-served and under-represented, focusing on the
most critical need to address the inequality for Black, Hispanic, Native American and Pacific Islander populations in California.

Core Values

Fostering and maintaining a strong, healthy culture is a key strategic focus. Our core values reflect who we are and the way our employees interact with one
another, our partners and our stockholders. We are dedicated to our core values, recognizing that this dedication will foster an environment where we will
be able to realize our vision of advancing patient care. We are Passionate, aware that with integrity and determination, we make a difference for patients.
We are Fearless, aware that by challenging convention, we truly innovate. We are Dedicated, aware that working tirelessly together, we are greater than the
sum of our parts. We are Inclusive, aware that with respect, grace and humor, we are family. We encourage our employees to live out our core values and to
discuss our core values with potential candidates looking to join our team. We believe that this is an important step in helping our culture stay strong and
unique.

Health, Safety, and Wellness

The health, safety, and wellness of our employees is a priority in which we have always invested, and will continue to do so. In response to the COVID-19
pandemic, we implemented significant changes that we determined were in the best interest of our employees, as well as the communities in which we
operate, in compliance with government regulations. This included having the vast majority of our employees work from home. We have reopened our
facilities and employees have returned to our facilities. We continue to offer hybrid and remote working opportunities for our team members employed in
areas within the organization where such flexible work options are possible. We will continue to adopt and align our policies to focus on the health, safety
and wellness of our employees, and the needs of our business.

Compensation and Benefits

We recognize that we operate within an industry where there is significant competition for top talent, and we endeavor to provide not only a strong healthy
culture,  but  also  important  compensation  and  benefits  programs  to  help  meet  the  needs  of  our  employees.  In  addition  to  base  compensation,  these
programs, include annual bonuses, stock awards, an Employee Stock Purchase Plan, 401(k) with company match contribution, healthcare and insurance
benefits, health savings (funded by the Company) and flexible spending accounts, family leave, family care resources, and flexible work schedules, among
many others.

Ensuring  fair  and  equitable  pay  is  integral  to  our  commitment  to  our  employees.  Our  executive  team  and  Board  of  Directors  strongly  support  this
commitment.  We  conduct  pay  equity  reviews  annually  to  help  us  understand  whether  our  compensation  structure  is  appropriate  and  to  identify  what
improvements can be made.

Corporate Information

We were founded in October 2007 as a Delaware corporation under the name Nteryx. We changed our name to Ardelyx, Inc. in June 2008. We operate in
one business segment, which is the development and commercialization of biopharmaceutical products. Our principal executive offices are located at 400
Fifth Avenue, Suite 210, Waltham, Massachusetts 02415, and our telephone number is (510) 745-1700. Our website address is www.ardelyx.com.

We file electronically with the Securities and Exchange Commission (SEC) our annual reports on Form 10-K, quarterly reports on Form 10-Q and current
reports  on  Form  8-K  pursuant  to  Section  13(a)  or  15(d)  of  the  Securities  Exchange  Act  of  1934,  as  amended.  We  make  available  on  our  website  at
www.ardelyx.com, free of charge, copies of these reports, as soon as reasonably practicable after we electronically file such material with, or furnish it to,
the  SEC.  The  SEC  maintains  a  website  that  contains  reports,  proxy  and  information  statements,  and  other  information  regarding  issuers  that  file
electronically with the SEC. The address of that website is www.sec.gov.

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ITEM 1A.     RISK FACTORS

Our business involves significant risks, some of which are described below. You should carefully consider these risks, as well as other information in this
Annual  Report  on  Form  10-K,  including  our  financial  statements  and  the  notes  thereto  and  “Management’s  Discussion  and  Analysis  of  Financial
Condition and Results of Operations.” The occurrence of any of the events or developments described below could harm our business, financial condition,
results of operations, cash flows, the trading price of our common stock and our growth prospects. Additional risks and uncertainties not presently known
to us or that we currently deem immaterial may also impair our business operations.

Risks Related to our Financial Condition and Capital Requirements

We  are  not  profitable  and  have  incurred  significant  losses  since  our  inception,  and  we  expect  to  incur  operating  losses  in  the  future  as  we
commercialize IBSRELA and XPHOZAH ,  incur  manufacturing  and  development  costs  for  tenapanor,  and  incur  research  and  development  costs
related to potential new product candidates.

® 

®

In  March  2022,  we  commenced  the  commercialization  of  our  first  product,  IBSRELA   (tenapanor)  for  the  treatment  of  irritable  bowel  syndrome  with
constipation (IBS-C) in adult patients and have generated approximately $95.6 million in net revenue from product sales through December 31, 2023. In
October 2023, we received U.S. Food and Drug Administration (FDA) approval for XPHOZAH (tenapanor)  for  the  reduction  of  serum  phosphorus  in
adults  with  chronic  kidney  disease  (CKD)  on  dialysis  as  add-on  therapy  in  patients  who  have  an  inadequate  response  to  phosphate  binders  or  who  are
intolerant of any dose of phosphate binder therapy. In November 2023, we commenced the commercialization of XPHOZAH and generated approximately
$2.5 million in net revenue from product sales through December 31, 2023.

® 

®

We are not profitable and have incurred losses in each year since our inception in October 2007, and we do not know whether or when we will become
profitable. We continue to incur significant commercialization, development and other expenses related to our ongoing operations. As of December 31,
2023, we had an accumulated deficit of $846.2 million.

We  expect  to  continue  to  incur  operating  losses  for  the  foreseeable  future  as  we  commercialize  IBSRELA  and  XPHOZAH,  incur  manufacturing  and
development costs for tenapanor, and incur research and development costs related to potential new product candidates.

There are no assurances that our efforts to meet our operating cash flow requirements will be successful. If our current cash, cash equivalents and short-
term  investments  as  well  as  our  plans  to  meet  our  operating  cash  flow  requirements  are  not  sufficient  to  fund  necessary  expenditures  and  meet  our
obligations, our liquidity, financial condition, and business prospects will be materially affected.

Our  prior  losses,  combined  with  expected  future  losses,  have  had  and  will  continue  to  have  an  adverse  effect  on  our  stockholders’  equity  and  working
capital. Further, the net losses we incur may fluctuate significantly from quarter-to-quarter and year-to-year, such that a period-to-period comparison of our
results of operations may not be a good indication of our future performance.

Our ability to utilize our net operating loss carryforwards and certain other tax attributes may be limited.

We  have  substantial  net  operating  loss  and  tax  credit  carryforwards  for  Federal  and  California  income  tax  purposes.  Such  net  operating  losses  and  tax
credits carryforwards may be reduced as a result of certain intercompany restructuring transactions. In addition, the future utilization of such net operating
loss and tax credit carryforwards and credits may be subject to limitations, pursuant to Sections 382 and 383 of the Internal Revenue Code of 1986, as
amended (the Code). In general, if a corporation undergoes an “ownership change,” generally defined as a cumulative change of more than 50 percentage
points (by value) in its equity ownership by certain stockholders over a three-year period, the corporation’s ability to use its pre-change net operating loss
(NOL) carryforwards and other pre-change tax attributes (such as research and development tax credits) to offset its post-change income or taxes may be
limited.  We  have  experienced  ownership  changes  in  the  past  and  may  experience  additional  ownership  changes  in  the  future,  as  a  result  of  subsequent
changes  in  our  stock  ownership,  some  of  which  are  outside  our  control.  Accordingly,  we  may  not  be  able  to  utilize  a  material  portion  of  our  NOL
carryforwards, even if we achieve profitability.

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We  will  require  additional  financing  for  the  foreseeable  future  as  we  invest  in  the  commercialization  of  IBSRELA  and  XPHOZAH  in  the  U.S.  and
incur research and development costs related to potential new product candidates. The inability to access necessary capital when needed on acceptable
terms, or at all, could force us to reduce our efforts to commercialize IBSRELA or XPHOZAH, or to delay or limit our pursuit of potential new product
candidates

We believe that we will continue to expend substantial resources for the foreseeable future, including costs associated with our efforts to commercialize
IBSRELA and XPHOZAH; conducting pediatric clinical trials for IBSRELA; manufacturing for IBSRELA and XPHOZAH and research and development
related to potential new product candidates. Our future funding requirements will depend on many factors, including, but not limited to:

•

•

•

the extent to which we are able to generate product revenue from sales of IBSRELA and XPHOZAH;

the availability of adequate third-party reimbursement for IBSRELA and XPHOZAH;

the manufacturing, selling and marketing costs associated with IBSRELA and XPHOZAH;

• whether or when XPHOZAH, along with other oral ESRD-related drugs without an injectable or intravenous equivalent, are bundled into the ESRD
prospective  payment  system  (ESRD  PPS),  the  manner  in  which  such  introduction  into  the  ESRD  PPS  may  occur,  including  the  length  of  any
applicable TDAPA period and the amount of the add-on payment available during the TDAPA period and whether, and the extent to which, the ESRD
PPS base rate is adjusted following any applicable TDAPA period;

•

•

•

•

•

•

•

our  ability  to  maintain  our  existing  collaboration  partnerships  and  to  establish  additional  collaboration  partnerships,  in-license/out-license,  joint
ventures or other similar arrangements and the financial terms of such agreements;

the timing, receipt and amount of any milestones that may be received from our collaboration partners in connection with tenapanor, if any;

the timing, receipt, and amount of royalties we may receive as a result of sales of tenapanor by our collaboration partners in China, and Canada, if any;

the cash requirements for the discovery and/or development of other potential product candidates, including RDX013 and RDX020;

the time and cost necessary to respond to technological and market developments;

the costs of filing, prosecuting, maintaining, defending and enforcing any patent claims and other intellectual property rights, including litigation costs
and  the  outcome  of  such  litigation,  and  costs  of  defending  any  claims  of  infringement  brought  by  others  in  connection  with  the  development,
manufacture or commercialization of tenapanor or any of our product candidates; and

the payment of interest and principal related to our loan and security agreement entered into with SLR Investment Corp., as amended to date.

Additional funds may not be available when we need them on terms that are acceptable to us, or at all. If adequate funds are not available to us on a timely
basis, we may be required to limit or reduce our commercialization of IBSRELA or XPOHZAH, delay or limit additional clinical trials for tenapanor, or
delay or limit our pursuit of potential new product candidates. Additionally, our inability to access capital on a timely basis and on terms that are acceptable
to us may force us to restructure certain aspects of our business or identify and complete one or more strategic collaborations or other transactions in order
to fund the commercialization of IBSRELA or XPHOZAH through the use of alternative structures.

We have generated limited revenue from product sales and may never be profitable.

We  began  selling  IBSRELA  in  the  U.S.  in  March  2022  and  have  generated  approximately  $95.6  million  in  net  revenue  from  product  sales  through
December 31, 2023. On October 17, 2023, our NDA for XPHOZAH was approved by the U.S. Food and Drug Administration’s (U.S. FDA). In November,
we commenced the commercialization of XPHOZAH and generated approximately $2.5 million in net revenue from product sales through December 31,
2023. We have no other products approved for sale.

There can be no assurances that we will generate sufficient product revenue from sales of IBSRELA and XPHOZAH to cover our expenses. Our ability to
generate product revenue from sales or pursuant to milestone or royalty payments depends heavily on many factors, including but not limited to:

•

our ability to successfully commercialize ISBRELA and XPHOZAH and to increase market share for both products;

• maintaining sufficient market acceptance of IBSRELA as a viable treatment option for IBS-C;

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•

•

obtaining market acceptance of XPHOZAH;

our ability to obtain and sustain an adequate level of coverage and reimbursement for IBSRELA and XPHOZAH by third-party payors;

• whether  or  when  XPHOZAH,  along  with  other  oral  ESRD-related  drugs  without  an  injectable  or  intravenous  equivalent,  are  bundled  into  the
ESRD PPS, the manner in which such introduction into the ESRD PPS may occur, including the length of any applicable TDAPA period and the
amount  of  the  add-on  payment  available  during  the  TDAPA  period  and  whether,  and  the  extent  to  which,  the  ESRD  PPS  base  rate  is  adjusted
following any applicable TDAPA period;

•

•

establishing  and  maintaining  supply  and  manufacturing  relationships  with  third  parties  that  can  provide  an  adequate  (in  amount  and  quality)
supply of product to support the market demand for IBSRELA and XPHOZAH;

addressing any competing technological and market developments;

• maintaining, protecting and expanding our portfolio of intellectual property rights, including patents, trade secrets, and know-how, and our ability
to develop, manufacture and commercialize our product candidates and products without infringing intellectual property rights of others; and

•

attracting, hiring, and retaining qualified personnel.

With respect to our commercialization of IBSRELA and XPHOZAH, our revenue will be dependent, in part, upon the size of the markets in the U.S., the
label  for  which  approval  was  granted,  accepted  price  for  the  product,  and  the  ability  to  get  reimbursement  at  any  price.  While  there  is  significant
uncertainty related to the insurance coverage and reimbursement of newly approved products in general in the U.S., there is additional uncertainty related
to insurance coverage and reimbursement for drugs, like XPHOZAH, which is being marketed for the reduction of serum phosphorus in adults with chronic
kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of any dose of
phosphate binder therapy. Our ability to generate and sustain future revenues from sales of XPHOZAH, will be significantly dependent upon whether and
when XPHOZAH, along with other oral end stage renal disease (ESRD)-related drugs without an injectable or intravenous equivalent, are bundled into the
ESRD PPS, and the manner in which such introduction into the ESRD PPS may occur. See “—Third-party payor coverage and reimbursement status of
newly commercialized products are uncertain. Failure to obtain or maintain adequate coverage and reimbursement for IBSRELA and XPHOZAH could
limit our ability to market those products and decrease our ability to generate revenue” and “—In the event no legislative or regulatory action is taken to
further delay the inclusion of oral only ESRD related drugs in the ESRD PPS, XPHOZAH will become part of the ESRD PPS on January 1, 2025, and will
no longer be separately paid for under Part D, and as a result the revenue that we may generate on sales of XPHOZAH will be negatively and materially
impacted”  below.  Additionally,  if  the  number  of  adult  patients  for  IBSRELA  and/or  XPHOZAH  is  not  as  significant  as  we  estimate,  coverage  and
reimbursement for either IBSRELA or XPHOZAH are not available in the manner and to the extent we expect, or the reasonably accepted population for
treatment is narrowed by competition, physician choice or treatment guidelines, we may not generate significant revenue from the sale of IBSRELA or
XPHOZAH.  Even  if  we  achieve  profitability  in  the  future,  we  may  not  be  able  to  sustain  profitability  in  subsequent  periods.  Our  failure  to  generate
adequate revenue from product sales would likely depress our market value and could impair our ability to raise capital, expand our business, discover or
develop other product candidates or continue our operations. A decline in the value of our common stock could cause our stockholders to lose all or part of
their investment.

Principal Risks Related to Our Business

We are substantially dependent on the successful commercialization of IBSRELA, and there is no guarantee that we will maintain sufficient market
acceptance for IBSRELA, grow market share for IBSRELA, secure and maintain adequate coverage and reimbursement for IBSRELA, or generate
sufficient revenue from product sales of IBSRELA.

We began selling IBSRELA in the U.S. in March 2022. The overall commercial success of IBSRELA will depend on a number of factors, including the
following:

•

•

•

•

•

the  ability  of  the  third-party  manufacturers  we  contract  with  to  provide  an  adequate  (in  amount  and  quality)  supply  of  product  to  support  the
market demand for IBSRELA;

our ability to obtain and sustain an adequate level of coverage and reimbursement for IBSRELA by third-party payors;

the effectiveness of IBSRELA as a treatment for adult patients with IBS-C;

the size of the treatable patient population;

our ability to continue to increase the market share of IBSRELA;

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•

the effectiveness of our sales, market access and marketing efforts;

• whether physicians view IBSRELA as a safe and effective treatment for adult patients with IBS-C, which will impact the adoption of IBSRELA

by physicians for the treatment of IBS-C;

•

•

•

•

•

the  availability,  perceived  advantages,  relative  cost,  relative  safety  and  relative  efficacy  of  IBSRELA  compared  to  alternative  and  competing
treatments;

the prevalence and severity of adverse side effects of IBSRELA;

our potential involvement in lawsuits in connection with enforcing intellectual property rights in and to IBSRELA;

our  potential  involvement  in  third-party  interference,  opposition,  derivation  or  similar  proceedings  with  respect  to  our  patent  rights  directed  to
IBSRELA, and avoiding other challenges to our patent rights and patent infringement claims; and

a continued acceptable safety and tolerability profile of IBSRELA following approval.

The amount of potential revenue we may achieve from the commercialization of IBSRELA is subject to these and other factors, and may be unpredictable
from quarter-to-quarter. If the number of patients in the market for IBSRELA or the price that the market can bear is not as significant as we estimate, or if
we are not able to continue to secure and maintain physician and patient acceptance of IBSRELA or adequate coverage and reimbursement for IBSRELA,
we  may  not  generate  sufficient  revenue  from  sales  of  IBSRELA.  Any  failure  of  IBSRELA  to  maintain  market  acceptance,  continue  to  increase  market
share,  obtain  and  maintain  sufficient  third-party  coverage  or  reimbursement,  or  achieve  commercial  success  would  adversely  affect  our  results  of
operations.

There is no guarantee that we will achieve sufficient market acceptance for XPHOZAH, secure and maintain adequate coverage and reimbursement
for XPHOZAH or generate sufficient revenue from product sales of XPHOZAH.

There is no guarantee that we will achieve sufficient market acceptance for XPHOZAH, secure and maintain adequate coverage and reimbursement for
XPHOZAH or generate sufficient revenue from product sales of XPHOZAH. The commercial success of XPHOZAH will depend on a number of factors,
including the following:

• whether or when XPHOZAH, along with other oral ESRD-related drugs without an injectable or intravenous equivalent, are bundled into the ESRD
PPS, the manner in which such introduction into the ESRD PPS may occur, including the length of any applicable TDAPA period and the amount of
the  add-on  payment  available  during  the  TDAPA  period  and  whether,  and  the  extent  to  which,  the  ESRD  PPS  base  rate  is  adjusted  following  any
applicable TDAPA period;

•

the ability of the third-party manufacturers we contract with to provide an adequate (in amount and quality) supply of product to support the market
demand for both IBSRELA and XPHOZAH;

• whether or not the content and breadth of the label that has been approved by the U.S. FDA for XPHOZAH will materially and adversely impact our

ability to commercialize the product for the approved indication;

the prevalence and severity of adverse side effects of XPHOZAH;

acceptance of XPHOZAH as safe, effective and well-tolerated by patients and the medical community;

our ability to manage the commercialization of IBSRELA and XPHOZAH and the complex pricing and reimbursement negotiations that may arise
with marketing products containing the same active ingredient at different doses for separate indications;

the  availability,  perceived  advantages,  relative  cost,  relative  safety  and  relative  efficacy  of  XPHOZAH  compared  to  alternative  and  competing
treatments;

obtaining and sustaining an adequate level of coverage and reimbursement for XPHOZAH by third-party payors;

our potential involvement in lawsuits in connection with enforcing intellectual property rights in and to XPHOZAH;

our potential involvement in third-party interference, opposition, derivation or similar proceedings with respect to our patent rights, and avoiding other
challenges to our patent rights and patent infringement claims; and

a continued acceptable safety and tolerability profile of XPHOZAH following approval.

•

•

•

•

•

•

•

•

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In the event no legislative or regulatory action is taken to further delay the inclusion of oral only ESRD related drugs in the ESRD PPS, XPHOZAH
will become part of the ESRD PPS on January 1, 2025, and will no longer be separately paid for under Part D, and as a result the revenue that we may
generate on sales of XPHOZAH will be negatively and materially impacted.

In January 2011, the Centers for Medicare & Medicaid Services (CMS), an agency within the United States Department of Health and Human Services
responsible  for  administering  the  Medicare  program,  implemented  the  ESRD  PPS,  a  new  prospective  payment  system  for  dialysis  treatment.  Under  the
ESRD PPS, CMS generally makes a single bundled payment to the dialysis facility for each dialysis treatment that covers all items and services routinely
required  for  dialysis  treatments  furnished  to  Medicare  beneficiaries  in  Medicare-certified  ESRD  facilities  or  at  their  home,  including  the  cost  of  certain
drugs  defined  by  CMS  to  be  part  of  the  renal  dialysis  service.  The  inclusion  of  oral  medications  without  injectable  or  intravenous  equivalents  in  the
bundled payment was initially delayed by CMS until January 1, 2014, and through several subsequent legislative actions has been delayed until January 1,
2025.

Absent further legislation or regulation on this matter, beginning in January 2025, oral ESRD-related drugs without injectable or intravenous equivalents,
including XPHOZAH and all other phosphate lowering medications, will be included in the ESRD bundle and separate Medicare payment for these drugs
will no longer be available, as is the case today under Medicare Part D. ESRD facilities may nonetheless receive a TDAPA for new renal dialysis drugs and
biological products that meet certain criteria for a period of two years. The TDAPA payment is based on 100 percent of average sales price (ASP). If ASP
is not available, then the TDAPA is based on 100 percent of wholesale acquisition cost (WAC). If WAC is unavailable, then the payment is based on the
drug manufacturer’s invoice. There can be no assurances that CMS will determine that XPHOZAH will qualify for TDAPA status. Even if deemed eligible
by CMS, revenue for sales of XPHOZAH could be significantly less in the TDAPA period than it would be if XPHOZAH is not bundled into the ESRD
PPS. Moreover, in the post-TPDAPA period, CMS currently expects to increase the single bundled payment base rate paid to the dialysis facility for each
dialysis treatment to reflect that oral only phosphate lowering drugs will be reimbursed as part of the single bundled payment for Medicare patients. There
can  be  no  assurances  that  any  increase  in  the  single  bundled  payment  base  rate  will  be  sufficient  to  adequately  reimburse  the  dialysis  facilities  for
XPOHZAH at a price that is profitable for us. The inclusion of XPHOZAH in the ESRD PPS would affect our ability to optimize the commercialization of
XPHOZAH, will negatively and materially impact the revenue that we may generate on sales of XPHOZAH and could materially impact our profitability,
results of operations, financial condition, and prospects.

IBSRELA and/or XPHOZAH may cause undesirable side effects or have other properties that could limit the commercial success of the product.

Undesirable side effects caused by IBSRELA and/or XPHOZAH could cause us or regulatory authorities to interrupt, delay or halt the commercialization
of  the  product.  Despite  marketing  approval  for  IBSRELA  and  XPHOZAH,  the  prevalence  and/or  severity  of  side  effects  caused  by  IBSRELA  and/or
XPHOZAH could result in a number of potentially significant negative consequences, including:

•

regulatory authorities may withdraw their approval of the product or seize the product;

• we or a collaboration partner may be required to recall the product;

•

additional restrictions may be imposed on the marketing of the particular product or the manufacturing processes for the product or any component
thereof, including the imposition of a Risk Evaluation and Mitigation Strategy (REMS) which could require creation of a Medication Guide or patient
package insert outlining the risks of such side effects for distribution to patients, a communication plan to educate healthcare providers of the drugs’
risks, as well as other elements to assure safe use of the product, such as a patient registry and training and certification of prescribers;

• we or a collaboration partner may be subject to fines, injunctions or the imposition of civil or criminal penalties;

•

regulatory authorities may require the addition of new labeling statements, such as a “black box” warning or a contraindication;

• we could be sued and held liable for harm caused to patients;

•

•

the product may become less competitive; and

our reputation may suffer.

Any  of  the  foregoing  events  could  prevent  us,  or  a  collaboration  partner,  from  achieving  or  maintaining  market  acceptance  of  IBSRELA  and/or
XPHOZAH, and could result in the loss of significant revenue to us, which would materially and adversely affect our results of operations and business.

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Third-party  payor  coverage  and  reimbursement  status  of  newly  commercialized  products  are  uncertain.  Failure  to  obtain  or  maintain  adequate
coverage  and  reimbursement  for  IBSRELA  and  XPHOZAH  could  limit  our  ability  to  market  those  products  and  decrease  our  ability  to  generate
revenue.

The  pricing,  coverage  and  reimbursement  of  IBSRELA  and  XPHOZAH  must  be  adequate  to  support  a  commercial  infrastructure.  The  availability  and
adequacy  of  coverage  and  reimbursement  by  governmental  and  private  payors  are  essential  for  most  patients  to  be  able  to  afford  treatments.  Sales  of
IBSRELA and XPHOZAH, will depend substantially, both domestically and abroad, on the extent to which the costs of the product will be paid for by
health maintenance, managed care, pharmacy benefit, and similar healthcare management organizations, or reimbursed by government authorities, private
health  insurers,  and  other  third-party  payors.  If  coverage  and  reimbursement  are  not  available,  or  are  available  only  to  limited  levels,  we,  or  our
collaboration  partners,  may  not  be  able  to  successfully  commercialize  IBSRELA,  or  XPHOZAH.  Even  if  coverage  is  provided,  the  approved
reimbursement amount may not be high enough to allow us to establish or maintain pricing sufficient to realize a return on our investment.

There is significant uncertainty related to the insurance coverage and reimbursement of newly approved products. In the U.S., the principal decisions about
coverage and reimbursement for new drugs are typically made by CMS, an agency within the United States Department of Health and Human Services
responsible  for  administering  the  Medicare  program,  as  CMS  decides  whether  and  to  what  extent  a  new  drug  will  be  covered  and  reimbursed  under
Medicare. Private payors tend to follow the coverage reimbursement policies established by CMS to a substantial degree. It is difficult to predict what CMS
will decide with respect to reimbursement for products such as ours. Additionally, absent legislative or regulatory action, XPHOZAH, along with other oral
ESRD related drugs without injectable or intravenous equivalents, will be included in the ESRD PPS beginning on January 1, 2025 at which time separate
Medicare payment for these drugs will no longer be available, as is the case today under Medicare Part D. While it is too early to project the full impact
that bundling may have on sales of XPHOZAH and on our business, should XPHOZAH be brought into the bundle in 2025, or at any time, we may be
unable to sell XPHOZAH to dialysis providers on a profitable basis. See “—In the event no legislative or regulatory action is taken to further delay the
inclusion of oral only ESRD related drugs in the ESRD PPS, XPHOZAH will become part of the ESRD PPS on January 1, 2025, and will no longer be
separately paid for under Part D, and as a result the revenue that we may generate on sales of XPHOZAH will be negatively and materially impacted”
above for a more detailed discussion related to the risks that may occur if XPHOZAH is brought into the bundle.

Outside the U.S., international operations are generally subject to extensive governmental price controls and other market regulations, and we believe the
increasing  emphasis  on  cost-containment  initiatives  in  Europe,  Canada,  Japan,  China  and  other  countries  has  and  will  continue  to  put  pressure  on  the
pricing  and  usage  of  IBSRELA  and  XPHOZAH,  even  if  regulatory  approval  is  received  in  such  countries.  In  many  countries,  the  prices  of  medical
products are subject to varying price control mechanisms as part of national health systems. Other countries allow companies to fix their own prices for
medicinal  products,  but  monitor  and  control  company  profits.  Additional  foreign  price  controls  or  other  changes  in  pricing  regulation  could  restrict  the
amount that we are able to charge for our product candidates. Accordingly, in markets outside the U.S., the reimbursement for our products may be reduced
compared with the U.S. and may be insufficient to generate commercially reasonable revenue and profits.

Moreover, increasing efforts by governmental and third-party payors in the U.S. and abroad to cap or reduce healthcare costs may cause such organizations
to limit both coverage and the level of reimbursement for newly approved products and, as a result, these caps may not cover or provide adequate payment
for our product candidates. We expect to experience pricing pressures in connection with the sale of IBSRELA and XPHOZAH, due to the trend toward
managed  healthcare,  the  increasing  influence  of  health  maintenance  organizations,  and  additional  legislative  changes.  The  downward  pressure  on
healthcare costs in general, particularly prescription drugs and surgical procedures and other treatments, has become very intense. As a result, increasingly
high barriers are being erected to the entry of new products.

We rely completely on third parties, including certain single-source suppliers, to manufacture IBSRELA and XPHOZAH. If they are unable to comply
with  applicable  regulatory  requirements,  unable  to  source  sufficient  raw  materials,  experience  manufacturing  or  distribution  difficulties  or  are
otherwise unable to manufacture sufficient quantities to meet demand, our commercialization of IBSRELA and XPHOZAH may be materially harmed.

We do not currently have, nor do we plan to acquire, the infrastructure or capability internally to manufacture IBSRELA or XPHOZAH on a commercial
scale, or to manufacture our drug supplies for use in the conduct of our nonclinical and clinical studies. Our success depends upon our ability to enter into
new supplier agreements and maintain our relationships with suppliers who are critical and necessary to the production of our drug supply.

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The facilities used by our contract manufacturing organizations (CMOs) to manufacture our drug supply are subject to inspection by the U.S. FDA. Our
ability to control the manufacturing process of our product candidates is limited to the contractual requirements and obligations we impose on our CMOs.
Although they are contractually required to do so, we are completely dependent on our CMOs for compliance with the regulatory requirements, known as
current Good Manufacturing Practice requirements (cGMPs), for manufacture of both active drug substances and finished drug products.

The  manufacture  of  pharmaceutical  products  requires  significant  expertise  and  capital  investment.  Manufacturers  of  pharmaceutical  products  often
encounter  difficulties  in  commercial  production.  These  problems  may  include  difficulties  with  production  costs  and  yields,  quality  control,  including
stability of the product and quality assurance testing, and shortages of qualified personnel, as well as compliance with federal, state and foreign regulations
and the challenges associated with complex supply chain management. Even if our CMOs do not experience problems and commercial manufacturing is
achieved,  their  maximum  or  available  manufacturing  capacities  may  be  insufficient  to  meet  commercial  demand.  Finding  alternative  manufacturers  or
adding additional manufacturers requires a significant amount of time and involves significant expense. New manufacturers would need to develop and
implement the necessary production techniques and processes, which along with their facilities, would need to be inspected and approved by the regulatory
authorities  in  each  applicable  territory.  In  addition,  the  raw  materials  necessary  to  make  API  for  our  products  are  acquired  from  a  limited  number  of
sources. Any delay or disruption in the availability of these raw materials could result in production disruptions, delays or higher costs with consequent
adverse effects on us.

If our CMOs fail to adhere to applicable GMP or other regulatory requirements, experience delays or disruptions in the availability of raw materials or
experience manufacturing or distribution problems, we may suffer significant consequences, including the inability to meet our product requirements for
our clinical development programs, and such events could result in product seizures or recalls, loss of product approval, fines and sanctions, reputational
damage, shipment delays, inventory shortages, inventory write-offs and other product-related charges and increased manufacturing costs. As a result, or if
maximum or available manufacturing capacities are insufficient to meet demand, our development or our commercialization efforts for IBSRELA and/or
XPHOZAH may be materially harmed.

Our future results depend on CMOs, many of whom are our single source manufacturers.

Many of our CMOs are currently single source manufacturers. While we try to obtain multiple sources whenever possible, similar to other commercial
pharmaceutical companies, three stages of our manufacturing process are currently completed by a single source, which exposes us to a number of risks
related to our supply chain, including delivery failure and drug shortages. To date, we have no qualified alternative sources for these single source CMOs.

Our  manufacturing  and  commercial  supply  agreements  with  our  CMOs,  including  our  single  source  CMOs,  contain  or  are  likely  to  contain  pricing
provisions that are subject to adjustment based on factors outside of our control, including changes in market prices. Substantial increases in the prices for
necessary materials and equipment, whether due to supply chain or logistics issues or due to inflation, would increase our operating costs and could reduce
our margins. Any attempts to increase the announced or expected prices of IBSRELA and/or XPHOZAH in response to increased costs could be viewed
negatively by the public and could adversely affect our business, prospects, financial condition, and results of operations.

An  inability  to  continue  to  source  product  from  any  of  these  CMOs,  which  could  be  due  to  regulatory  actions  or  requirements  affecting  the  supplier,
adverse  financial  or  other  strategic  developments  experienced  by  a  CMO,  labor  disputes  or  shortages,  unexpected  demands,  or  quality  issues,  could
adversely affect our ability to satisfy demand for our products, which could adversely and materially affect our product sales and operating results, which
could  significantly  harm  our  business.  Furthermore,  qualifying  alternate  suppliers  or  developing  our  own  manufacturing  capability  for  certain  highly
customized stages of our manufacturing process may be time consuming and costly. There can be no assurance that our business, financial condition, and
results of operations will not be materially and adversely affected by supply chain disruptions. Any disruption in the supply chain, whether or not from a
single source CMO, could temporarily disrupt production of our drug supply until an alternative supplier is fully qualified by us or until such CMO is able
to perform. There can be no assurance that we would be able to successfully retain an alternative CMO on a timely basis, on acceptable terms, or at all.
Changes in business conditions, force majeure, governmental changes, and other factors beyond our control or which we do not presently anticipate, could
also  affect  our  CMOs’  ability  to  deliver  components  to  us  on  a  timely  basis.  Any  of  the  foregoing  could  materially  and  adversely  affect  our  results  of
operations, financial condition, and prospects.

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Our  operating  activities  may  be  restricted  as  a  result  of  covenants  related  to  the  indebtedness  under  our  loan  and  security  agreement  with  SLR,  as
amended, and we may be required to repay the outstanding indebtedness in an event of default, which could have a materially adverse effect on our
business.

On February 23, 2022, we entered into a loan and security agreement with SLR (Lender) pursuant to which the Lender agreed to provide us with a loan
facility for up to $50.0 million with a maturity date of March 1, 2027, and on August 1, 2022, February 9, 2023 and October 17, 2023, we entered into
amendments to the loan and security agreement (collectively, the 2022 Loan Agreement). The loan was funded in the amount of $27.5 million on February
23, 2022 and an additional amount of $22.5 million was drawn on October 19, 2023. We may draw an additional $50.0 million on or before March 15,
2024, and we expect to draw this additional $50.0 million prior to expiry of the option on March 15, 2024. In addition, subject to the Lender approval of its
investment committee, we may be able to draw up to an additional $50 million by December 31, 2026. Until we have repaid all funded indebtedness, the
2022 Loan Agreement subjects us to various customary covenants, including requirements as to financial reporting and insurance and restrictions on our
ability to dispose of our business or property, to change our line of business, to liquidate or dissolve, to enter into any change in control transaction, to
merge  or  consolidate  with  any  other  entity  or  to  acquire  all  or  substantially  all  the  capital  stock  or  property  of  another  entity,  to  incur  additional
indebtedness, to incur liens on our property, to pay any dividends or other distributions on capital stock other than dividends payable solely in capital stock,
to redeem capital stock, to enter into licensing agreements, to engage in transactions with affiliates, and to encumber our intellectual property. Our business
may be adversely affected by these restrictions on our ability to operate our business.

We are permitted to make interest only payments on the loan facility through December 31, 2026, with principal repayments commencing on January 1,
2027.  In  addition,  we  may  be  required  to  repay  the  outstanding  indebtedness  under  the  loan  facility  if  an  event  of  default  occurs  under  the  2022  Loan
Agreement.  An  event  of  default  will  occur  if,  among  other  things,  we  fail  to  make  payments  under  the  2022  Loan  Agreement;  we  breach  any  of  our
covenants under the 2022 Loan Agreement, subject to specified cure periods with respect to certain breaches; the Lender determines that a material adverse
change has occurred; we or our assets become subject to certain legal proceedings, such as bankruptcy proceedings; we are unable to pay our debts as they
become due; or we default on contracts with third parties which would permit the Lender to accelerate the maturity of such indebtedness or that could have
a material adverse change on us. We may not have enough available cash or be able to raise additional funds through equity or debt financings to repay
such indebtedness at the time any such event of default occurs. In this case, we may be required to limit or reduce our activities necessary to commercialize
IBSRELA  and/or  XPHOZAH,  or  delay  or  limit  clinical  trials  for  tenapanor  or  other  product  candidates.  The  Lender  could  also  exercise  its  rights  as
collateral  agent  to  take  possession  of  and  to  dispose  of  the  collateral  securing  the  term  loans,  which  collateral  includes  substantially  all  of  our  property
(excluding  intellectual  property,  which  is  subject  to  a  negative  pledge).  Our  business,  financial  condition  and  results  of  operations  could  be  materially
adversely affected as a result of any of these events.

Additional Risks Related to Our Business and Industry

Clinical drug development involves a lengthy and expensive process with an uncertain outcome.

Before  obtaining  marketing  approval  from  regulatory  authorities  for  the  sale  of  our  product  candidates,  we  must  conduct  extensive  clinical  studies  to
demonstrate  the  safety  and  efficacy  of  the  product  candidates  in  humans.  Clinical  testing  is  expensive  and  can  take  many  years  to  complete,  and  its
outcome  is  inherently  uncertain.  For  example,  while  the  results  of  our  Phase  2  clinical  trial  evaluating  RDX013  for  the  treatment  of  hyperkalemia
demonstrated an acceptable safety and tolerability profile for RDX013 and supported proof of concept in its ability to lower serum potassium levels, with
statistically significant reductions compared to placebo after eight days of treatment, the study did not meet its primary endpoint of significantly reducing
serum potassium levels compared to placebo after four weeks of treatment. We currently expect that the next step for the program will be to evaluate a new
formulation  that  potentially  enhances  subject  compliance  and  the  efficacy  of  RDX013  in  an  additional  Phase  2  clinical  study  at  such  time  as  we  have
determined that our available resources support conducting such an additional clinical study. There can be no assurances that any additional clinical study
that we determine to conduct with RDX013 will be successful.

Additionally, if we conduct additional clinical trials with RDX013 or any other product candidates, we could encounter delays in our future development if
any clinical trials are suspended or terminated by us, by the institutional review boards of the institutions in which the trial is being conducted, or by the
U.S. FDA or other regulatory authorities. Such authorities may suspend or terminate a clinical trial due to a number of factors, including failure to conduct
the clinical trial in accordance with regulatory requirements or our clinical protocols, inspection of the clinical trial operations or trial site by the U.S. FDA
or other regulatory authorities resulting in the imposition of a clinical hold, unforeseen safety issues or adverse side effects, failure to demonstrate a benefit
from using a drug, changes in governmental regulations or administrative actions or lack of adequate funding to continue the clinical trial.

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In addition, identifying and qualifying patients to participate in any clinical trials is critical to the success of the clinical trials. The timing of any future
clinical trials, including any additional RDX013 clinical trial that we may determine to conduct, will depend, in part, on the speed at which we can recruit
patients to participate in testing our product candidates. Patients may be unwilling to participate in our clinical studies because of concerns about adverse
events  observed  with  the  current  standard  of  care,  competitor  products  and/or  other  investigational  agents,  in  each  case  for  the  same  indications  and/or
similar patient populations. In addition, patients currently receiving treatment with the current standard of care or a competitor product may be reluctant to
participate in a clinical trial with an investigational drug, or our inclusion and exclusion criteria for our clinical trials may present challenges in identifying
acceptable patients. As a result, the timeline for recruiting patients and conducting clinical trials may be delayed. These delays could result in increased
costs, delays in advancing our development of the program, or termination of the clinical studies altogether. Any of these occurrences may significantly
harm our business, financial condition and prospects.

We  will  rely  on  third  parties  to  conduct  all  of  our  nonclinical  studies  and  clinical  trials.  If  these  third  parties  do  not  successfully  carry  out  their
contractual duties or meet expected deadlines, we may be unable to obtain regulatory approval for additional products or commercialize our product
candidates.

We do not have the ability to independently conduct nonclinical studies or clinical trials. We rely on medical institutions, clinical investigators, contract
laboratories, and other third parties, such as Contract Research Organizations (CROs), to conduct clinical trials on our product candidates. The third parties
with whom we contract for execution of the clinical trials play a significant role in the conduct of these trials and the subsequent collection and analysis of
data. However, these third parties are not our employees, and except for contractual duties and obligations, we control only certain aspects of their activities
and have limited ability to control the amount or timing of resources that they devote to our programs. Although we rely, and will continue to rely, on these
third  parties  to  conduct  our  nonclinical  studies  and  our  clinical  trials,  we  remain  responsible  for  ensuring  that  each  of  our  studies  and  clinical  trials  is
conducted in accordance with the applicable protocol, legal, regulatory and scientific standards and our reliance on third parties does not relieve us of our
regulatory responsibilities. We, and these third parties are required to comply with current GLPs for nonclinical studies, and good clinical practices (GCPs)
for  clinical  studies.  GLPs  and  GCPs  are  regulations  and  guidelines  enforced  by  the  U.S.  FDA,  the  Competent  Authorities  of  the  Member  States  of  the
European Economic Area (EEA) and comparable foreign regulatory authorities for all of our products in nonclinical and clinical development, respectively.
Regulatory authorities enforce GCPs through periodic inspections of trial sponsors, principal investigators and trial sites. If we or any of our third-party
contractors  fail  to  comply  with  applicable  regulatory  requirements,  including  GCPs,  the  clinical  data  generated  in  our  clinical  trials  may  be  deemed
unreliable and the U.S. FDA, the European Medicines Agency (EMA), or comparable foreign regulatory authorities may require us to perform additional
clinical trials before approving our marketing applications. There can be no assurance that upon inspection by a given regulatory authority, such regulatory
authority  will  determine  that  any  of  our  clinical  trials  comply  with  GCP  regulations.  In  addition,  our  clinical  trials  must  be  conducted  with  product
produced under cGMP regulations. Our failure to comply with these regulations may require us to repeat clinical trials, which could add additional costs
and could delay the regulatory approval process.

We face substantial competition, and our competitors may discover, develop or commercialize products faster or more successfully than us.

The  biotechnology  and  pharmaceutical  industries  are  highly  competitive,  and  we  face  significant  competition  from  companies  in  the  biotechnology,
pharmaceutical  and  other  related  markets  that  are  researching  and  marketing  products  designed  to  address  diseases  that  we  are  currently  developing
products to treat.

Competition for IBSRELA largely comes from three prescription products marketed for certain patients with IBS-C that we are aware of, including Linzess
(linaclotide), Amitiza (lubiprostone) and Trulance (plecanatide). Generic lubiprostone is also available in the U.S. Additionally, over-the-counter products
not indicated for IBS-C are commonly used to treat the constipation component of IBS-C, alone and in combination with the IBS-C-indicated prescription
therapies.

XPHOZAH is indicated to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an
inadequate  response  to  phosphate  binders  or  who  are  intolerant  of  any  dose  of  phosphate  binder  therapy.  The  various  types  of  phosphate  binders
commercialized  in  the  U.S.  include  the  following:  Calcium  acetate  (several  prescription  brands  including  PhosLo  and  Phoslyra);  Lanthanum  carbonate
(Fosrenol); Sevelamer hydrochloride (Renagel); Sevelamer carbonate (Renvela); Sucroferric oxyhydroxide (Velphoro); and Ferric citrate (Auryxia). All of
the  listed  phosphate  binders  are  available  as  generics  in  the  U.S.,  with  the  exception  of  Velphoro  and  Auryxia.  Additionally,  over-the-counter  calcium
carbonate, such as Tums and Caltrate, is also used to bind phosphorus.

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In addition to the currently available phosphate binders, we are aware of at least four phosphate binders in development, including fermagate (Alpharen),
an iron-based binder in Phase 3 being developed by Opko Health, Inc., PT20, an iron-based binder in Phase 3 being developed by Shield Therapeutics, AP-
301, a binder in Phase 3 being developed by Alebund Pharmaceutical (Hong Kong) Limited, and Oxylanthanum Carbonate (OLC), which has demonstrated
pharmacodynamic  bioequivalence  to  Fosrenol.  OLC  is  being  developed  by  Unicycive  Therapeutics,  which  has  announced  its  plans  to  seek  U.S.  FDA
approval via the 505(b)(2) pathway. Additionally, Chugai and Alebund are developing EOS789/AP-306, an inhibitor of phosphate transporters NaPi-2b,
PiT-1, and PiT-2, thus far studied in a Phase 2 clinical trial.

It  is  possible  that  our  competitors'  drugs  may  be  less  expensive  and  more  effective  than  our  product  candidates,  or  may  render  our  product  candidates
obsolete. It is also possible that our competitors will commercialize competing drugs or treatments before we or our collaboration partners can launch any
products developed from our product candidates. We also may face increased competition in the future as new companies enter into our target markets.

Many of our competitors have materially greater name recognition and financial, manufacturing, marketing, research and drug development resources than
we do. Additional mergers and acquisitions in the biotechnology and pharmaceutical industries may result in even more resources being concentrated in our
competitors. Large pharmaceutical companies in particular have extensive expertise in preclinical and clinical testing and in obtaining regulatory approvals
for  drugs.  In  addition,  academic  institutions,  government  agencies,  and  other  public  and  private  organizations  conducting  research  may  seek  patent
protection with respect to potentially competitive products or technologies. These organizations may also establish exclusive collaboration partnerships or
licensing relationships with our competitors.

We may experience difficulties in managing our current activities and growth given our level of managerial, operational, financial and other resources.

While  we  have  continued  to  work  to  optimize  our  management  composition,  personnel  and  systems  to  support  our  current  activities  for  future  growth,
these resources may not be adequate for this purpose. Our need to effectively execute our business strategy requires that we:

• manage any commercialization activities in which we may engage effectively;

• manage our clinical trials effectively;

• manage our internal development efforts effectively while carrying out our contractual obligations to licensors, contractors, collaborators, government

agencies and other third parties;

•

•

continue to improve our operational, financial and management controls, reporting systems and procedures; and

retain and motivate our remaining employees and potentially identify, recruit, and integrate additional employees.

If we are unable to maintain or expand our managerial, operational, financial and other resources to the extent required to manage our development and
commercialization activities, our business will be materially adversely affected.

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If product liability lawsuits are brought against us, we may incur substantial liabilities and may be required to limit commercialization of IBSRELA
and/or XPHOZAH.

We  face  an  inherent  risk  of  product  liability  as  a  result  of  the  clinical  testing  of  our  product  candidates  and  our  commercialization  of  IBSRELA  and
XPOHZAH. For example, we may be sued if any product we develop and/or commercialize allegedly causes injury or is found to be otherwise unsuitable
during product testing, manufacturing, marketing or sale. Any such product liability claims may include allegations of defects in manufacturing, defects in
design, a failure to warn of dangers inherent in the product, negligence, strict liability, and a breach of warranties. Claims could also be asserted under state
consumer protection acts. If we cannot successfully defend ourselves against product liability claims, we may incur substantial liabilities or be required to
limit commercialization of our product candidates. Even successful defense would require significant financial and management resources. Regardless of
the merits or eventual outcome, liability claims may result in:

•

•

decreased demand for the product;

injury to our reputation;

• withdrawal of clinical trial participants;

•

•

•

•

•

•

costs to defend the related litigation;

a diversion of management’s time and our resources;

substantial monetary awards to trial participants or patients;

regulatory investigations, product recalls or withdrawals, or labeling, marketing or promotional restrictions;

loss of revenue; and

the inability to commercialize or co-promote IBSRELA and/or XPHOZAH.

Our inability to obtain and maintain sufficient product liability insurance at an acceptable cost and scope of coverage to protect against potential product
liability claims could prevent or inhibit the commercialization of any products we develop. Although we maintain product liability insurance, any claim
that may be brought against us could result in a court judgment or settlement in an amount that is not covered, in whole or in part, by our insurance or that
is  in  excess  of  the  limits  of  our  insurance  coverage.  Our  insurance  policies  also  have  various  exclusions  and  deductibles,  and  we  may  be  subject  to  a
product liability claim for which we have no coverage. We will have to pay any amounts awarded by a court or negotiated in a settlement that exceed our
coverage limitations or that are not covered by our insurance, and we may not have, or be able to obtain, sufficient capital to pay such amounts. Moreover,
in the future, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts to protect us against losses.

If we fail to attract, retain and motivate our executives, senior management and key personnel, our business will suffer.

Recruiting and retaining qualified scientific, clinical, medical, manufacturing, and sales and marketing personnel is critical to our success. We are highly
dependent on our executives, senior management and certain other key employees. The loss of the services of our executives, senior management or other
key employees could impede the achievement of our development and commercial objectives and seriously harm our ability to successfully implement our
business strategy. Furthermore, replacing executives, senior management and other key employees may be difficult and may take an extended period of
time because of the limited number of individuals in our industry with the breadth of skills and experience required to successfully develop, gain marketing
approval of and commercialize products. We may be unable to hire, train or motivate these key personnel on acceptable terms given the intense competition
among numerous biopharmaceutical companies for similar personnel, particularly in our geographic regions. If we are unable to continue to attract and
retain high quality personnel, our ability to grow and pursue our business strategy will be limited.

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Actual or perceived failures to comply with applicable data protection, privacy and security laws, regulations, standards and other requirements could
adversely affect our business, results of operations, and financial condition.

The global data protection landscape is rapidly evolving, and we are or may become subject to numerous state, federal and foreign laws, requirements and
regulations governing the collection, use, disclosure, retention, and security of personal data, such as information that we may collect in connection with
clinical trials in the U.S. and abroad. Implementation standards and enforcement practices are likely to remain uncertain for the foreseeable future, and we
cannot  yet  determine  the  impact  future  laws,  regulations,  standards,  or  perception  of  their  requirements  may  have  on  our  business.  This  evolution  may
create  uncertainty  in  our  business;  affect  our  ability  to  operate  in  certain  jurisdictions,  or  to  collect,  store,  transfer  use  and  share  personal  information;
necessitate the acceptance of more onerous obligations in our contracts; result in liability; or impose additional costs on us. The cost of compliance with
these laws, regulations and standards is high and is likely to increase in the future. Any failure or perceived failure by us to comply with federal, state or
foreign laws or regulation, our internal policies and procedures or our contracts governing our processing of personal information could result in negative
publicity, government investigations and enforcement actions, claims by third parties and damage to our reputation, any of which could have a material
adverse effect on our operations, financial performance and business.

As our operations and business grow, we may become subject to or affected by new or additional data protection laws and regulations and face increased
scrutiny or attention from regulatory authorities. In the U.S., the Health Insurance Portability and Accountability Act of 1996, as amended, and regulations
promulgated  thereunder  (collectively  HIPAA)  imposes,  among  other  things,  certain  standards  relating  to  the  privacy,  security,  transmission,  and  breach
reporting of individually identifiable health information. We may obtain health information from third parties (including research institutions from which
we obtain clinical trial data) that are subject to privacy and security requirements under HIPAA. Depending on the facts and circumstances, we could be
subject to significant penalties if we violate HIPAA.

Certain states have also adopted comparable privacy and security laws and regulations, some of which may be more stringent than HIPAA. Such laws and
regulations will be subject to interpretation by various courts and other governmental authorities, thus creating potentially complex compliance issues for
us and our future customers and strategic partners. For example, the California Consumer Privacy Act (CCPA) went into effect on January 1, 2020. The
CCPA creates individual privacy rights for California consumers and increases the privacy and security obligations of entities handling certain personal
information. The CCPA provides for civil penalties for violations, as well as a private right of action for data breaches that has increased the likelihood of,
and  risk  associated  with  data  breach  litigation.  Further,  the  California  Privacy  Rights  Act  (CPRA)  generally  went  into  effect  on  January  1,  2023  and
significantly amends the CCPA. It imposes additional data protection obligations on covered businesses, including additional consumer rights processes,
limitations on data uses, new audit requirements for higher risk data, and opt outs for certain uses of sensitive data. It also creates a new California data
protection  agency  authorized  to  issue  substantive  regulations  and  could  result  in  increased  privacy  and  information  security  enforcement.  Additional
compliance investment and potential business process changes may also be required. Similar laws have passed in other states and are continuing to be at the
state  and  federal  level,  reflecting  a  trend  toward  more  stringent  privacy  legislation  in  the  U.S.  The  enactment  of  such  laws  could  have  potentially
conflicting requirements that would make compliance challenging. In the event that we are subject to or affected by HIPAA, the CCPA, the CPRA or other
domestic privacy and data protection laws, any liability from failure to comply with the requirements of these laws could adversely affect our financial
condition.

Furthermore, the Federal Trade Commission (FTC) also has authority to initiate enforcement actions against entities that mislead customers about HIPAA
compliance, make deceptive statements about privacy and data sharing in privacy policies, fail to limit third-party use of personal health information, fail to
implement policies to protect personal health information or engage in other unfair practices that harm customers or that may violate Section 5(a) of the
FTC Act. According to the FTC, failing to take appropriate steps to keep consumers’ personal information secure can constitute unfair acts or practices in
or affecting commerce in violation of Section 5(a) of the Federal Trade Commission Act. The FTC and many state Attorneys General continue to enforce
federal and state consumer protection laws against companies for online collection, use, dissemination and security practices that appear to be unfair or
deceptive, including on websites, to regulate the presentation of website content. The FTC expects a company’s data security measures to be reasonable and
appropriate in light of the sensitivity and volume of consumer information it holds, the size and complexity of its business, and the cost of available tools to
improve security and reduce vulnerabilities.

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We are also or may become subject to rapidly evolving data protection laws, rules and regulations in foreign jurisdictions. For example, in Europe, the
European Union General Data Protection Regulation (GDPR) went into effect in May 2018 and imposes strict requirements for processing the personal
data of individuals within the European Economic Area (EEA). Companies that must comply with the GDPR face increased compliance obligations and
risk, including more robust regulatory enforcement of data protection requirements and potential fines for noncompliance of up to €20 million or 4% of the
annual  global  revenues  of  the  noncompliant  company,  whichever  is  greater.  Among  other  requirements,  the  GDPR  regulates  transfers  of  personal  data
subject to the GDPR to third countries that have not been found to provide adequate protection to such personal data, including the U.S. and the efficacy
and  longevity  of  current  transfer  mechanisms  between  the  EEA,  and  the  United  States  remains  uncertain.  Case  law  from  the  Court  of  Justice  of  the
European Union (CJEU) states that reliance on the standard contractual clauses - a standard form of contract approved by the European Commission as an
adequate personal data transfer mechanism - alone may not necessarily be sufficient in all circumstances and that transfers must be assessed on a case-by-
case basis. On July 10, 2023, the European Commission adopted its Adequacy Decision in relation to the new EU-US Data Privacy Framework (DPF),
rendering  the  DPF  effective  as  a  GDPR  transfer  mechanism  to  U.S.  entities  self-certified  under  the  DPF.  We  expect  the  existing  legal  complexity  and
uncertainty  regarding  international  personal  data  transfers  to  continue.  In  particular,  we  expect  the  DPF  Adequacy  Decision  to  be  challenged  and
international  transfers  to  the  United  States  and  to  other  jurisdictions  more  generally  to  continue  to  be  subject  to  enhanced  scrutiny  by  regulators.  As  a
result,  we  may  have  to  make  certain  operational  changes  and  we  will  have  to  implement  revised  standard  contractual  clauses  and  other  relevant
documentation for existing data transfers within required time frames.

Relatedly, following the United Kingdom’s withdrawal from the EEA and the European Union, and the expiry of the transition period, companies have had
to comply with both the GDPR and the GDPR as incorporated into United Kingdom national law, the latter regime having the ability to separately fine up
to the greater of £17.5 million or 4% of global turnover. On October 12, 2023, the UK Extension to the DPF came into effect (as approved by the UK
Government), as a data transfer mechanism from the United Kingdom to U.S. entities self-certified under the DPF. As we continue to expand into other
foreign countries and jurisdictions, we may be subject to additional laws and regulations that may affect how we conduct business.

Although we work to comply with applicable laws, regulations and standards, our contractual obligations and other legal obligations, these requirements
are evolving and may be modified, interpreted and applied in an inconsistent manner from one jurisdiction to another, and may conflict with one another or
other  legal  obligations  with  which  we  must  comply.  Any  failure  or  perceived  failure  by  us  or  our  employees,  representatives,  contractors,  consultants,
CROs, collaborators, or other third parties to comply with such requirements or adequately address privacy and security concerns, even if unfounded, could
result in additional cost and liability to us, damage our reputation, and adversely affect our business and results of operations.

We and our collaborators, CROs and other contractors and consultants depend on information technology systems, and any failure of these systems
could  harm  our  business.  Security  breaches,  loss  of  data,  and  other  disruptions  could  compromise  sensitive  information  related  to  our  business  or
prevent us from accessing critical information and expose us to liability, which could adversely affect our business, results of operations and financial
condition.

We and our collaborators, CROs, and other contractors and consultants collect and maintain information in digital form that is necessary to conduct our
business, and we are increasingly dependent on information technology systems and infrastructure to operate our business. In the ordinary course of our
business,  we  and  our  collaborators,  CROs  and  other  contractors  and  consultants  collect,  store  and  transmit  large  amounts  of  confidential  information,
including intellectual property, proprietary business information, clinical trial data and personal information (collectively, Confidential Information). It is
critical that we and our collaborators, CROs and other contractors and consultants do so in a secure manner to maintain the confidentiality and integrity of
such  Confidential  Information.  We  have  established  physical,  electronic  and  organizational  measures  designed  to  safeguard  and  secure  our  systems  to
prevent a data compromise, and rely on commercially available systems, software, tools, and monitoring to provide security for our information technology
systems  and  the  processing,  transmission  and  storage  of  Confidential  Information.  We  have  also  outsourced  elements  of  our  information  technology
infrastructure, and as a result a number of third-party vendors may or could have access to our Confidential Information.

Our information technology systems and infrastructure, and those of our current and any future collaborators, CROs, contractors and consultants and other
third  parties  on  which  we  rely,  are  vulnerable  to  attack,  damage  and  interruption  from  computer  viruses,  malware  (e.g., ransomware),  natural  disasters,
terrorism, war, telecommunication and electrical failures, cyber-attacks or cyber-intrusions over the Internet, phishing attacks and other social engineering
schemes, attachments to emails, human error, fraud, denial or degradation of service attacks, sophisticated nation-state and nation-state-supported actors or
unauthorized access or use by persons inside our organization, or persons with access to systems inside our organization.

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The  risk  of  a  security  breach  or  disruption  or  data  loss,  particularly  through  cyberattacks  or  cyber  intrusion,  including  by  computer  hackers,  foreign
governments and cyber terrorists, has generally increased as the number, intensity and sophistication of attempted attacks and intrusions from around the
world have increased. In addition, the prevalent use of mobile devices that access Confidential Information increases the risk of data security breaches,
which could lead to the loss of Confidential Information or other intellectual property. We may also face increased cybersecurity risks due to our reliance
on internet technology and the number of our employees who are working remotely, which may create additional opportunities for cybercriminals to exploit
vulnerabilities.  Furthermore,  because  the  techniques  used  to  obtain  unauthorized  access  to,  or  to  sabotage,  systems  change  frequently  and  often  are  not
recognized until launched against a target, we may be unable to anticipate these techniques or implement adequate preventative measures. We may also
experience  security  breaches  that  may  remain  undetected  for  an  extended  period.  Even  if  identified,  we  may  be  unable  to  adequately  investigate  or
remediate incidents or breaches due to attackers increasingly using tools and techniques that are designed to circumvent controls, to avoid detection, and to
remove  or  obfuscate  forensic  evidence.  The  costs  to  us  to  mitigate  network  security  problems,  bugs,  viruses,  worms,  malicious  software  programs  and
security  vulnerabilities  could  be  significant,  and  while  we  have  implemented  security  measures  to  protect  our  data  security  and  information  technology
systems,  our  efforts  to  address  these  problems  may  not  be  successful,  and  these  problems  could  result  in  unexpected  interruptions,  delays,  cessation  of
service  and  other  harm  to  our  business  and  our  competitive  position.  There  can  also  be  no  assurance  that  our  and  our  collaborators’,  CROs’,  CMOs,
contractors’, consultants’ and other service providers’ cybersecurity risk management program and processes, including policies, controls or procedures,
will be fully implemented, complied with or effective in protecting our systems, networks and Confidential Information.

We and certain of our service providers are from time to time subject to cyberattacks and security incidents. We do not believe that we have experienced
any significant system failure, accident or security breach to date, but if such an event were to occur and cause interruptions in our operations, it could
result  in  a  material  disruption  to  our  business.  In  addition,  such  a  breach  may  require  notification  to  governmental  agencies,  the  media  or  individuals
pursuant to various federal and state privacy and security laws, if applicable. Moreover, if a computer security breach affects our systems or those of our
collaborators, CROs or other contractors, or results in the unauthorized release of personally identifiable information, our reputation could be materially
damaged. Any adverse impact to the availability, integrity or confidentiality of our or third-party systems or Confidential Information can result in legal
claims  or  proceedings  (such  as  class  actions),  regulatory  investigations  and  enforcement  actions,  fines  and  penalties,  negative  reputational  impacts  that
cause us to lose existing or future customers, and/or significant incident response, system restoration or remediation and future compliance costs, which
could materially adversely affect our business, results of operations and financial condition.

If we fail to maintain proper and effective internal controls, our ability to produce accurate and timely financial statements could be impaired, which
could harm our operating results, our ability to operate our business and investors’ views of us and could have a material adverse effect on the price of
our common stock.

Our failure to implement and maintain effective internal controls over financial reporting could result in errors in our financial statements that could result
in  a  restatement  of  our  financial  statements  and  cause  us  to  fail  to  meet  our  reporting  obligations.  If  we  cannot  in  the  future  favorably  assess  the
effectiveness of our internal controls over financial reporting, investor confidence in the reliability of our financial reports may be adversely affected, which
could have a material adverse effect on the trading price of our common stock.

We have formed in the past, and may form in the future, collaboration partnerships, joint ventures and/or licensing arrangements, and we may not
realize the benefits of such collaborations.

We have current collaboration partnerships for the commercialization of tenapanor in certain foreign countries, and we may form additional collaboration
partnerships, create joint ventures or enter into additional licensing arrangements with third parties in the U.S. and abroad that we believe will complement
or  augment  our  existing  business.  In  particular,  we  have  formed  collaboration  partnerships  with  Kyowa  Kirin  for  commercialization  of  tenapanor  for
hyperphosphatemia in Japan; with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. (Fosun Pharma) for commercialization of tenapanor
for hyperphosphatemia and IBS-C in China and related territories; in Canada with Knight Therapeutics, Inc. (Knight) for commercialization of tenapanor
for IBS-C and hyperphosphatemia; and with METiS Therapeutics, Inc. (METiS) for the development and commercialization of a portfolio of TGR5 agonist
compounds  for  all  therapeutic  areas.  We  face  significant  competition  in  seeking  appropriate  collaboration  partners,  and  the  process  to  identify  an
appropriate partner and negotiate appropriate terms is time-consuming and complex. Any delays in identifying suitable additional collaboration partners
and entering into agreements to develop our product candidates could also delay the commercialization of our product candidates, which may reduce their
competitiveness even if they reach the market. There is no guarantee that our current collaboration partnerships or any such arrangements we enter into in
the future will be successful, or that any collaboration partner will

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commit sufficient resources to the development, regulatory approval, and commercialization effort for such products, or that such alliances will result in us
achieving revenues that justify such transactions.

We may engage in strategic transactions that could impact our liquidity, increase our expenses and present significant distractions to our management.

We  may  consider  strategic  transactions,  such  as  acquisitions  of  companies,  asset  purchases,  and/or  in-licensing  of  products,  product  candidates  or
technologies. In addition, if we are unable to access capital on a timely basis and on terms that are acceptable to us, we may be forced to further restructure
certain aspects of our business or identify and complete one or more strategic collaborations or other transactions in order to fund the commercialization of
IBSRELA and XPHOZAH, and/or the development of discovery and developmental assets through the use of alternative structures. Additional potential
transactions  that  we  may  consider  include  a  variety  of  different  business  arrangements,  including  spin-offs,  spin  outs,  collaboration  partnerships,  joint
ventures, restructurings, divestitures, business combinations and investments. Any such transaction may require us to incur non-recurring or other charges,
may increase our near- and long-term expenditures and may pose significant integration challenges or disrupt our management or business, which could
adversely affect our operations and financial results. For example, these transactions may entail numerous operational and financial risks, including:

•

•

•

•

•

up-front, milestone and royalty payments, equity investments and financial support of new research and development candidates including increase of
personnel, all of which may be substantial;

exposure to unknown liabilities;

disruption  of  our  business  and  diversion  of  our  management’s  time  and  attention  in  order  to  develop  acquired  products,  product  candidates  or
technologies;

incurrence of substantial debt or dilutive issuances of equity securities;

higher-than-expected acquisition and integration costs;

• write-downs of assets or goodwill or impairment charges;

•

•

•

•

increased amortization expenses;

difficulty and cost in combining the operations and personnel of any acquired businesses with our operations and personnel;

impairment of relationships with key suppliers or customers of any acquired businesses due to changes in management and ownership; and

inability to retain key employees of any acquired businesses.

Accordingly,  although  there  can  be  no  assurance  that  we  will  undertake  or  successfully  complete  any  transactions  of  the  nature  described  above,  any
transactions  that  we  do  complete  may  be  subject  to  the  foregoing  or  other  risks  and  could  have  a  material  adverse  effect  on  our  business,  results  of
operations, financial condition and prospects.

Our CMOs manufacture tenapanor API outside of the U.S., our collaboration partners outside of the U.S. have sought and obtained and may continue
to seek and obtain approval to commercialize tenapanor outside of the U.S., and as a result a variety of risks associated with international operations
could materially adversely affect our business.

Our collaboration partners have sought and obtained and may continue to seek and obtain marketing approval for tenapanor outside the U.S. Furthermore,
we  may  seek  and  obtain  marketing  approval  for  IBSRELA  or  XPHOZAH  in  other  territories  outside  of  the  U.S.  Additionally,  we  have  contractual
agreements  with  CMOs  involving  the  manufacture  of  tenapanor  API  outside  of  the  U.S.,  and  may  otherwise  engage  in  business  outside  of  the  U.S.,
including  entering  into  additional  contractual  agreements  with  third  parties.  We  are  subject  to  additional  risks  related  to  entering  these  international
business markets and relationships, including:

•

•

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•

•

•

different regulatory requirements for drug approvals in foreign countries;

differing U.S. and foreign drug import and export rules;

reduced protection for intellectual property rights in foreign countries;

unexpected changes in tariffs, trade barriers and regulatory requirements;

different reimbursement systems, and different competitive drugs;

economic weakness, including inflation, or political instability in particular foreign economies and markets;

compliance with tax, employment, immigration and labor laws for employees living or traveling abroad;

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•

•

foreign taxes, including withholding of payroll taxes;

foreign  currency  fluctuations,  which  could  result  in  increased  operating  expenses  and  reduced  revenues,  and  other  obligations  incident  to  doing
business in another country;

• workforce uncertainty in countries where labor unrest is more common than in the U.S.;

•

•

•

production shortages resulting from any events affecting raw material supply or manufacturing capabilities abroad;

potential liability resulting from development work conducted by these distributors; and

business interruptions resulting from geopolitical actions, including war and terrorism, or natural disasters.

Our  business  involves  the  use  of  hazardous  materials  and  we  and  third-parties  with  whom  we  contract  must  comply  with  environmental  laws  and
regulations, which can be expensive and restrict how we do business.

We and manufacturers and suppliers with whom we may contract are subject to laws and regulations governing the use, manufacture, storage, handling, and
disposal  of  hazardous  materials,  including  the  components  of  our  tenapanor  and  our  product  candidates.  In  some  cases,  these  hazardous  materials  and
various wastes resulting from their use are stored at our and our manufacturers’ facilities pending their use and disposal. We cannot eliminate the risk of
contamination,  which  could  cause  an  interruption  of  our  commercialization  efforts,  and  business  operations,  and  could  result  in  environmental  damage
requiring  costly  clean-up  and  resulting  in  liabilities  under  applicable  laws  and  regulations  governing  the  use,  storage,  handling  and  disposal  of  these
materials and specified waste products. We cannot guarantee that the safety procedures utilized by third-party manufacturers and suppliers with whom we
may contract will comply with the standards prescribed by laws and regulations or will eliminate the risk of accidental contamination or injury from these
materials. In such an event, we may be held liable for any resulting damages and such liability could exceed our resources and state or federal or other
applicable authorities may curtail our use of certain materials and/or interrupt our business operations. Furthermore, environmental laws and regulations are
complex, change frequently and have tended to become more stringent. We cannot predict the impact of such changes and cannot be certain of our future
compliance. We do not currently carry biological or hazardous waste insurance coverage.

We may be adversely affected by earthquakes or other natural disasters and our business continuity and disaster recovery plans may not adequately
protect us from a serious disaster.

We  currently  occupy  a  leased  facility  located  in  the  San  Francisco  Bay  Area,  which  in  the  past  has  experienced  severe  earthquakes.  We  do  not  carry
earthquake  insurance.  Earthquakes  or  other  natural  disasters  could  severely  disrupt  our  operations,  and  have  a  material  adverse  effect  on  our  business,
results of operations, financial condition and prospects.

If a natural disaster, power outage or other event occurred that prevented us from using all or a significant portion of our leased facilities, including our
California  facility,  that  damaged  critical  infrastructure  supporting  access  to  systems  such  as  our  enterprise  financial  systems  or  manufacturing  resource
planning  and  enterprise  quality  systems,  or  that  otherwise  disrupted  operations,  it  may  be  difficult  or  time  consuming  to  restore  some  business  of  our
business functions. The disaster recovery and business continuity plans we have in place currently are not holistic in coverage and may prove inadequate in
the event of a serious disaster or similar event. We may incur substantial expenses as a result of the limited nature of our disaster recovery and business
continuity plans, which, particularly when taken together with our lack of earthquake insurance, could have a material adverse effect on our business.

Risks Related to Government Regulation

Despite  having  received  regulatory  approval  for  IBSRELA  and  XPHOZAH,  we  will  be  subject  to  ongoing  regulatory  obligations  and  continued
regulatory review, which may result in significant additional expense. Additionally, IBSRELA and XPHOZAH could be subject to other restrictions
and market withdrawal, and we may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated problems with
our products.

Even  after  a  drug  is  approved  by  the  U.S.  FDA  or  foreign  regulatory  authorities,  the  manufacturing  processes,  labeling,  packaging,  distribution,
pharmacovigilance, storage, advertising, promotion and recordkeeping for the product will be subject to extensive and ongoing regulatory requirements.
These  requirements  include  submissions  of  safety  and  other  post-marketing  information  and  reports,  registration,  as  well  as  continued  compliance  with
cGMPs  and  GCP  regulations  for  any  clinical  trials  that  we  conduct  post-approval.  As  such,  we  and  our  third-party  CMOs  will  be  subject  to  continual
review  and  periodic  inspections  to  assess  compliance  with  regulatory  requirements.  Accordingly,  we  and  others  with  whom  we  work  must  continue  to
expend time, money, and effort in all areas of regulatory compliance, including manufacturing, production, and quality control. Regulatory authorities may
also impose significant restrictions on a product’s indicated uses or marketing or impose

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ongoing requirements for potentially costly post-marketing studies. Furthermore, any new legislation addressing drug safety issues could result in delays or
increased costs to assure compliance.

We will also be required to report certain adverse reactions and production problems, if any, to the U.S. FDA, and to comply with requirements concerning
advertising and promotion for our products. Promotional communications with respect to prescription drugs are subject to a variety of legal and regulatory
restrictions and must be consistent with the information in the product’s approved label. As such, we may not promote our products for indications or uses
for which they do not have U.S. FDA approval.

Later discovery of previously unknown problems with a product, including adverse events of unanticipated severity or frequency, or with our third-party
manufacturers or manufacturing processes, or failure to comply with regulatory requirements, may result in, among other things:

• warning or untitled letters or fines;

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•

•

•

restrictions on the marketing or manufacturing of the product, withdrawal of the product from the market or voluntary or mandatory product recalls;

injunctions or the imposition of civil or criminal penalties;

suspension or revocation of existing regulatory approvals;

suspension of any of our ongoing clinical trials;

refusal to approve pending applications or supplements to approved applications submitted by us;

restrictions on our or our CMOs’ operations; or

product seizure or detention, or refusal to permit the import or export of products.

Any  government  investigation  of  alleged  violations  of  law  could  require  us  to  expend  significant  time  and  resources  in  response  and  could  generate
negative  publicity.  Any  failure  to  comply  with  ongoing  regulatory  requirements  may  significantly  and  adversely  affect  our  ability  to  commercialize
IBSRELA and XPHOZAH. If regulatory sanctions are applied or if regulatory approval is withdrawn, the value of our company and our operating results
will be adversely affected.

In addition, the U.S. FDA’s policies may change, and additional government regulations may be enacted. If we are slow or unable to adapt to changes in
existing requirements or the adoption of new requirements or policies, or if we are not able to maintain regulatory compliance, we may lose any marketing
approval that we may have obtained, which would adversely affect our business, prospects and ability to achieve or sustain profitability.

We also cannot predict the likelihood, nature or extent of government regulation that may arise from future legislation or administrative or executive action,
either in the U.S. or abroad.

Disruptions at the U.S. FDA and other government agencies caused by funding shortages or global health concerns could hinder their ability to hire
and  retain  key  leadership  and  other  personnel,  or  otherwise  review  and  process  regulatory  submissions  in  a  timely  manner,  which  could  negatively
impact our business.

The ability of the FDA to review and process regulatory submissions can be affected by a variety of factors, including government budget and funding
levels, ability to hire and retain key personnel and accept the payment of user fees, and statutory, regulatory, policy changes, and other events that may
otherwise affect the FDA’s ability to perform routine functions. For example, over the last several years, the U.S. government has shut down several times
and certain regulatory agencies, such as the FDA, have had to furlough critical FDA employees and stop critical activities.

Disruptions at the U.S. FDA and other agencies may also slow the time necessary for new drugs to be reviewed and/or approved by necessary government
agencies, which would adversely affect our business. If a prolonged government shutdown occurs, or if global health concerns prevent the U.S. FDA or
other regulatory authorities from conducting their regular inspections, reviews, or other regulatory activities, it could significantly impact the ability of the
U.S.  FDA  or  other  regulatory  authorities  to  timely  review  and  process  our  regulatory  submissions,  which  could  have  a  material  adverse  effect  on  our
business.

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We  and  our  CMOs  are  subject  to  significant  regulation  with  respect  to  manufacturing  IBSRELA  and  XPHOZAH.  The  manufacturing  facilities  on
which we rely may not continue to meet regulatory requirements or may not be able to meet supply demands.

All entities involved in the preparation of product for commercial sale, or product candidates for clinical trials, including our existing CMOs are subject to
extensive  regulation.  Components  of  a  finished  therapeutic  product  approved  for  commercial  sale  or  used  in  late-stage  clinical  studies  must  be
manufactured in accordance with cGMP regulations. These regulations govern manufacturing processes and procedures (including record keeping) and the
implementation and operation of quality systems to control and assure the quality of investigational products and products approved for sale. Poor control
of  production  processes  can  lead  to  the  introduction  of  contaminants  or  to  inadvertent  changes  in  the  properties  or  stability  of  our  products  or  product
candidates  that  may  not  be  detectable  in  final  product  testing.  We  or  our  CMOs  must  supply  all  necessary  documentation  in  support  of  an  NDA  or
comparable regulatory filing on a timely basis and must adhere to cGMP regulations enforced by the U.S. FDA and other regulatory agencies through their
facilities inspection programs. The facilities and quality systems of some, or all, of our CMOs must pass a pre-approval inspection for compliance with the
applicable  regulations  as  a  condition  of  regulatory  approval  of  our  product  candidates.  In  addition,  the  regulatory  authorities  may,  at  any  time,  audit  or
inspect  a  manufacturing  facility  involved  with  the  manufacture  of  our  product  or  the  associated  quality  systems  for  compliance  with  the  regulations
applicable  to  the  activities  being  conducted.  Although  we  oversee  the  CMOs,  we  cannot  control  the  manufacturing  process  of,  and  are  completely
dependent  on,  our  CMOs  for  compliance  with  the  regulatory  requirements.  If  these  facilities  do  not  pass  a  pre-approval  plant  inspection,  regulatory
approval of the products may not be granted or may be substantially delayed until any violations are corrected to the satisfaction of the regulatory authority,
if ever. In addition, we have no control over the ability of our CMOs to maintain adequate quality control, quality assurance and qualified personnel.

The  regulatory  authorities  also  may,  at  any  time  following  approval  of  a  product  for  sale,  audit  the  manufacturing  facilities  of  our  CMOs.  If  any  such
inspection or audit identifies a failure to comply with applicable regulations or if a violation of our product specifications or applicable regulations occurs
independent  of  such  an  inspection  or  audit,  we  or  the  relevant  regulatory  authority  may  require  remedial  measures  that  may  be  costly  and/or  time
consuming for us or a third party to implement, and that may include the temporary or permanent suspension of a clinical study or commercial sales or the
temporary or permanent suspension of production or closure of a facility. Any such remedial measures imposed upon us or third parties with whom we
contract could materially harm our business.

If we or any of our third-party manufacturers fail to maintain regulatory compliance, the U.S. FDA or other applicable regulatory authority can impose
regulatory  sanctions  including,  among  other  things,  refusal  to  approve  a  pending  application  for  a  new  drug  product,  withdrawal  of  an  approval,  or
suspension of production. As a result, our business, financial condition, and results of operations may be materially harmed.

Additionally,  if  supply  from  one  approved  manufacturer  is  interrupted,  an  alternative  manufacturer  would  need  to  be  qualified  through  an  NDA,  a
supplemental NDA or equivalent foreign regulatory filing, which could result in further delay. The regulatory agencies may also require additional studies
if a new manufacturer is relied upon for commercial production. Switching manufacturers may involve substantial costs and is likely to result in a delay in
our desired clinical and commercial timelines.

These factors could cause us to incur higher costs and could cause the delay or termination of clinical studies, regulatory submissions, required approvals,
or commercialization of our product candidates. Furthermore, if our suppliers fail to meet contractual requirements and we are unable to secure one or more
replacement suppliers capable of production at a substantially equivalent cost, our clinical studies may be delayed, or we could lose potential revenue.

If we fail to comply or are found to have failed to comply with U.S. FDA and other regulations related to the promotion of our products for unapproved
uses, we could be subject to criminal penalties, substantial fines or other sanctions and damage awards.

The regulations relating to the promotion of products for unapproved uses are complex and subject to substantial interpretation by the U.S. FDA and other
government agencies. With respect to the commercialization of IBSRELA and/or XPHOZAH, we will be restricted from marketing the product outside of
its approved labeling, also referred to as off-label promotion. However, physicians may nevertheless prescribe an approved product to their patients in a
manner that is inconsistent with the approved label, which is an off-label use. We have implemented compliance and training programs designed to ensure
that our sales and marketing practices comply with applicable regulations regarding off-label promotion. Notwithstanding these programs, the U.S. FDA or
other government agencies may allege or find that our practices constitute prohibited promotion of our product candidates for unapproved uses. We also
cannot be sure that our employees will comply with company policies and applicable regulations regarding the promotion of products for unapproved uses.

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Over the past several years, a significant number of pharmaceutical and biotechnology companies have been the target of inquiries and investigations by
various federal and state regulatory, investigative, prosecutorial and administrative entities in connection with the promotion of products for unapproved
uses and other sales practices, including the Department of Justice and various U.S. Attorneys’ Offices, the Office of Inspector General of the Department
of Health and Human Services, the U.S. FDA, the FTC and various state Attorneys General offices. These investigations have alleged violations of various
federal and state laws and regulations, including claims asserting antitrust violations, violations of the Federal Food, Drug, and Cosmetic Act, the False
Claims  Act,  the  Prescription  Drug  Marketing  Act,  anti-kickback  laws,  and  other  alleged  violations  in  connection  with  the  promotion  of  products  for
unapproved  uses,  pricing  and  Medicare  and/or  Medicaid  reimbursement.  Many  of  these  investigations  originate  as  “qui  tam”  actions  under  the  False
Claims Act. Under the False Claims Act, any individual can bring a claim on behalf of the government alleging that a person or entity has presented a false
claim, or caused a false claim to be submitted, to the government for payment. The person bringing a qui tam suit is entitled to a share of any recovery or
settlement. Qui tam suits, also commonly referred to as “whistleblower suits,” are often brought by current or former employees. In a qui tam suit, the
government must decide whether to intervene and prosecute the case. If it declines, the individual may pursue the case alone.

If the U.S. FDA or any other governmental agency initiates an enforcement action against us or if we are the subject of a qui tam suit and it is determined
that we violated prohibitions relating to the promotion of products for unapproved uses, we could be subject to substantial civil or criminal fines or damage
awards  and  other  sanctions  such  as  consent  decrees  and  corporate  integrity  agreements  pursuant  to  which  our  activities  would  be  subject  to  ongoing
scrutiny and monitoring to ensure compliance with applicable laws and regulations. Any such fines, awards or other sanctions would have an adverse effect
on our revenue, business, financial prospects and reputation.

IBSRELA and/or XPHOZAH may cause or contribute to adverse medical events that we are required to report to regulatory agencies and if we fail to
do so we could be subject to sanctions that would materially harm our business.

We are required to report certain information about adverse medical events if our products may have caused or contributed to those adverse events. The
timing of our obligation to report is triggered by the date we become aware of the adverse event as well as the nature of the event. We may fail to report
adverse events we become aware of within the prescribed timeframe. We may also fail to appreciate that we have become aware of a reportable adverse
event, especially if it is not reported to us as an adverse event or if it is an adverse event that is unexpected or removed in time from the use of our products.
If  we  fail  to  comply  with  our  reporting  obligations,  the  U.S.  FDA  or  a  foreign  regulatory  agency  could  take  action,  including  criminal  prosecution,  the
imposition of civil monetary penalties, seizure of our products or delay in approval or clearance of future products.

Our  employees,  independent  contractors,  principal  investigators,  CROs,  collaboration  partners,  consultants,  CMOs  and  vendors  may  engage  in
misconduct or other improper activities, including noncompliance with regulatory standards and requirements.

We  are  exposed  to  the  risk  that  our  employees,  independent  contractors,  principal  investigators,  CROs,  collaboration  partners,  consultants,  CMOs  and
vendors may engage in fraudulent conduct or other illegal activity. Misconduct by these parties could include intentional, reckless and/or negligent conduct
or unauthorized activities that violate any of the following: U.S. FDA regulations, including those laws that require the reporting of true, complete and
accurate financial and other information to the U.S. FDA; manufacturing standards; or federal and state healthcare fraud and abuse laws and regulations.
Specifically, sales, marketing and business arrangements in the healthcare industry are subject to extensive laws and regulations intended to prevent fraud,
kickbacks, self-dealing and other abusive practices. These laws and regulations may restrict or prohibit a wide range of pricing, discounting, marketing and
promotion, sales commission, customer incentive programs and other business arrangements. These activities also include the improper use of information
obtained in the course of clinical trials, which could result in regulatory sanctions and serious harm to our reputation. It is not always possible to identify
and  deter  misconduct  by  employees  and  other  third  parties,  and  the  precautions  we  take  to  detect  and  prevent  this  activity  may  not  be  effective  in
controlling  unknown  or  unmanaged  risks  or  losses  or  in  protecting  us  from  governmental  investigations  or  other  actions  or  lawsuits  stemming  from  a
failure  to  comply  with  such  laws  or  regulations.  Additionally,  we  are  subject  to  the  risk  that  a  person  or  government  could  allege  such  fraud  or  other
misconduct, even if none occurred. If any such actions are instituted against us, and we are not successful in defending ourselves or asserting our rights,
those actions could have a significant impact on our business, including the imposition of significant civil, criminal and administrative penalties, damages,
monetary  fines,  disgorgements,  possible  exclusion  from  participation  in  Medicare,  Medicaid  and  other  federal  healthcare  programs,  individual
imprisonment, other sanctions, contractual damages, reputational harm, diminished profits and future earnings, and curtailment of our operations, any of
which could adversely affect our ability to operate our business and our results of operations.

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Failure to obtain regulatory approvals in foreign jurisdictions would prevent us from marketing our products internationally.

In order to market any product in the EEA (which is composed of the 27 Member States of the European Union plus Norway, Iceland and Liechtenstein),
and  many  other  foreign  jurisdictions,  separate  regulatory  approvals  are  required.  In  the  EEA,  medicinal  products  can  only  be  commercialized  after
obtaining a Marketing Authorization (MA). Before the MA is granted, the EMA or the competent authorities of the Member States of the EEA make an
assessment of the risk-benefit balance of the product on the basis of scientific criteria concerning its quality, safety and efficacy.

The approval procedures vary among countries and can involve additional clinical testing, and the time required to obtain approval may differ from that
required to obtain U.S. FDA approval. Clinical trials conducted in one country may not be accepted by regulatory authorities in other countries. Approval
by the U.S. FDA does not ensure approval by regulatory authorities in other countries, and approval by one or more foreign regulatory authorities does not
ensure approval by regulatory authorities in other foreign countries or by the U.S. FDA. However, a failure or delay in obtaining regulatory approval in one
country may have a negative effect on the regulatory process in others. The foreign regulatory approval process may include all of the risks associated with
obtaining U.S. FDA approval. We may not be able to file for regulatory approvals or to do so on a timely basis, and even if we do file, we may not receive
necessary approvals to commercialize our products in any market.

We  and  our  collaboration  partners  are  subject  to  healthcare  laws,  regulation  and  enforcement;  our  failure  or  the  failure  of  any  such  collaboration
partners to comply with these laws could have a material adverse effect on our results of operations and financial conditions.

We and our collaboration partners are subject to additional healthcare statutory and regulatory requirements and enforcement by the federal government
and the states and foreign governments in which we conduct our business. The laws that may affect our ability to operate as a commercial organization
include:

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the federal Anti-Kickback Statute, which prohibits, among other things, persons from knowingly and willfully soliciting, receiving, offering or paying
remuneration, directly or indirectly, in exchange for or to induce either the referral of an individual for, or the purchase, order or recommendation of,
any good or service for which payment may be made under federal healthcare programs such as the Medicare and Medicaid programs. A person or
entity does not need to have actual knowledge of this statute or specific intent to violate it in order to have committed a violation;

federal false claims laws which prohibit, among other things, individuals or entities from knowingly presenting, or causing to be presented, claims for
payment  from  Medicare,  Medicaid,  or  other  third-party  payors  that  are  false  or  fraudulent.  In  addition,  the  government  may  assert  that  a  claim
including items or services resulting from a violation of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the
false claims statutes;

the federal Civil Monetary Penalties law, which prohibits, among other things, offering or transferring remuneration to a federal healthcare beneficiary
that  a  person  knows  or  should  know  is  likely  to  influence  the  beneficiary’s  decision  to  order  or  receive  items  or  services  reimbursable  by  the
government from a particular provider or supplier;

federal  criminal  laws  that  prohibit  executing  a  scheme  to  defraud  any  healthcare  benefit  program  or  making  false  statements  relating  to  healthcare
matters. Similar to the federal Anti-Kickback Statute, a person or entity does not need to have actual knowledge of these statutes or specific intent to
violate them in order to have committed a violation;

the  federal  Physician  Payments  Sunshine  Act  requirements  under  the  Affordable  Care  Act  (ACA),  which  requires  manufacturers  of  drugs,  devices,
biologics,  and  medical  supplies  to  report  annually  to  CMS  information  related  to  payments  and  other  transfers  of  value  to  physicians,  (defined  to
include  doctors,  dentists,  optometrists,  podiatrists  and  chiropractors),  certain  non-physician  practitioners  (physician  assistants,  nurse  practitioners,
clinical nurse specialists, certified nurse anesthetists, anesthesiologist assistants and certified nurse midwives), and teaching hospitals, and ownership
and investment interests held by physicians (as defined by the statute) and their immediate family members;

state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws which may apply to items or services reimbursed
by any third-party payor, including commercial insurers;

state  laws  that  require  pharmaceutical  companies  to  comply  with  the  pharmaceutical  industry’s  voluntary  compliance  guidelines  and  the  applicable
compliance  guidance  promulgated  by  the  federal  government,  or  otherwise  restrict  payments  that  may  be  made  to  healthcare  providers  and  other
potential referral sources;

state laws that require drug manufacturers to report information related to payments and other transfers of value to physicians and other healthcare
providers or pricing information and marketing expenditures; and

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European  and  other  foreign  law  equivalents  of  each  of  the  laws,  including  reporting  requirements  detailing  interactions  with  and  payments  to
healthcare providers.

Because of the breadth of these laws and the narrowness of the statutory exceptions and safe harbors available, it is possible that some of our business
activities could be subject to challenge under one or more of such laws. The risk of our being found in violation of these laws is increased by the fact that
many of them have not been fully interpreted by the regulatory authorities or the courts, and their provisions are open to a variety of interpretations. Any
action against us for violation of these laws, even if we successfully defend against it, could cause us to incur significant legal expenses and divert our
management’s attention from the operation of our business. If our operations are found to be in violation of any of the laws described above or any other
governmental laws and regulations that apply to us, we may be subject to penalties, including civil and criminal penalties, damages, fines, the curtailment
or  restructuring  of  our  operations,  the  exclusion  from  participation  in  federal  and  state  healthcare  programs  and  imprisonment,  any  of  which  could
adversely affect our ability to market our products and adversely impact our financial results.

Legislative or regulatory healthcare reforms in the U.S. may make it more difficult and costly for us to obtain regulatory clearance or approval of our
product candidates and to produce, market and distribute our products after clearance or approval is obtained.

From  time  to  time,  legislation  is  drafted  and  introduced  in  Congress  that  could  significantly  change  the  statutory  provisions  governing  the  regulatory
clearance or approval, manufacture, and marketing of regulated products or the reimbursement thereof. In addition, U.S. FDA regulations and guidance are
often  revised  or  reinterpreted  by  the  FDA  in  ways  that  may  significantly  affect  our  business  and  our  products.  Any  new  regulations  or  revisions  or
reinterpretations of existing regulations may impose additional costs or lengthen review times of our product candidates. We cannot determine what effect
changes in regulations, statutes, legal interpretation or policies, when and if promulgated, enacted or adopted may have on our business in the future. Such
changes could, among other things, require:

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additional clinical trials to be conducted prior to obtaining approval;

changes to manufacturing methods;

recall, replacement, or discontinuance of one or more of our products; and

additional record keeping.

Each of these would likely entail substantial time and cost and could materially harm our business and our financial results. In addition, delays in receipt of
or failure to receive regulatory clearances or approvals for any future products would harm our business, financial condition and results of operations.

In addition, the full impact of recent healthcare reform and other changes in the healthcare industry and in healthcare spending is currently unknown, and
may  adversely  affect  our  business  model.  In  the  U.S.,  the  ACA  was  enacted  in  2010  with  a  goal  of  reducing  the  cost  of  healthcare  and  substantially
changing  the  way  healthcare  is  financed  by  both  government  and  private  insurers.  Since  its  enactment,  there  have  been  judicial,  executive  and
Congressional challenges to certain aspects of the ACA. The ACA, among other things, increased the minimum Medicaid rebates owed by manufacturers
under the Medicaid Drug Rebate Program and extended the rebate program to individuals enrolled in Medicaid managed care organizations, established
annual fees and taxes on manufacturers of certain branded prescription drugs, and created a new Medicare Part D coverage gap discount program, in which
manufacturers must now agree to offer 70% point-of-sale discounts off negotiated prices of applicable brand drugs to eligible beneficiaries during their
coverage gap period as a condition for the manufacturer’s outpatient drugs to be covered under Medicare Part D.

Other legislative changes have been proposed and adopted in the U.S. since the ACA was enacted. These new laws, among other things, included aggregate
reductions of Medicare payments to providers that will remain in effect through 2032, with the exception of a temporary suspension from May 1, 2020
through March 31, 2022, unless additional action is taken by Congress, additional specific reductions in Medicare payments to several types of providers,
including  hospitals,  imaging  centers  and  cancer  treatment  centers,  and  an  increase  in  the  statute  of  limitations  period  for  the  government  to  recover
overpayments to providers from three to five years. More recently, on March 11, 2021, President Biden signed the American Rescue Plan Act of 2021 into
law, which eliminated the statutory Medicaid drug rebate cap beginning January 1, 2024. The rebate was previously capped at 100% of a drug's average
manuacturer price.

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Recently, there has also been heightened governmental scrutiny over the manner in which drug manufacturers set prices for their marketed products, which
has resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review the
relationship  between  pricing  and  manufacturer  patient  programs,  and  reform  government  program  reimbursement  methodologies  for  drug  products.  On
August 16, 2022, the Inflation Reduction Act of 2022 (the IRA) was signed into law. Among other things, the IRA requires manufacturers of certain drugs
to engage in price negotiations with Medicare (beginning in 2026), imposes rebates under Medicare Part B and Medicare Part D to penalize price increases
that outpace inflation (first due in 2023), and replaces the Part D coverage gap discount program with a new discounting program (beginning in 2025).
Under the IRA, small molecule drugs and biologics first become eligible for price negotiation seven and eleven years, respectively, after FDA approval.
The IRA permits the Secretary of the Department of Health and Human Services to implement many of these provisions through guidance, as opposed to
regulation, for the initial years. On August 29, 2023, HHS announced the list of the first ten drugs that will be subject to price negotiations. HHS has issued
and will continue to issue guidance implementing the IRA, although the Medicare drug price negotiation program is currently subject to legal challenges.
While the impact of the IRA on the pharmaceutical industry cannot yet be fully determined, it is likely to be significant. Additionally, individual states have
become  increasingly  active  in  passing  legislation  and  implementing  regulations  designed  to  control  pharmaceutical  product  pricing,  including  price  or
patient reimbursement constraints, discounts, restrictions on certain product access, and to encourage importation from other countries and bulk purchasing.

We cannot predict the reform initiatives that may be adopted in the future or whether initiatives that have been adopted will be repealed or modified. The
continuing efforts of the government, insurance companies, managed care organizations and other payors of healthcare services to contain or reduce costs
of healthcare may adversely affect the demand for any drug products for which we may obtain regulatory approval, our ability to set a price that we believe
is fair for our products, our ability to obtain coverage and reimbursement approval for a product, our ability to generate revenues and achieve or maintain
profitability, and the level of taxes that we are required to pay.

If we fail to comply with our reporting and payment obligations under the Medicaid Drug Rebate Program or other governmental pricing programs in
the U.S., we could be subject to additional reimbursement requirements, penalties, sanctions and fines, which could have a material adverse effect on
our business, results of operations and financial condition.

With the commercial launch of IBSRELA, we participate in the Medicaid Drug Rebate Program (MDRP) and other federal and state government
pricing  programs  in  the  U.S.,  and  we  may  participate  in  additional  government  pricing  programs  in  the  future.  These  programs  generally  require
manufacturers to pay rebates or otherwise provide discounts to government payors in connection with drugs that are dispensed to beneficiaries of these
programs. Medicaid drug rebates are based on pricing data that we will be obligated to report on a monthly and quarterly basis to CMS, the federal agency
that administers the MDRP and Medicare programs. For the MDRP, these data include the average manufacturer price (AMP) and the best price (BP) for
each drug. If we become aware that our MDRP price reporting submission for a prior period was incorrect or has changed as a result of recalculation of the
pricing data, we must resubmit the corrected data for up to three years after those data originally were due. In addition, there is increased focus by the
Office of Inspector General within the U.S. Department of Health and Human Services on the methodologies used by manufacturers to calculate AMP, and
BP,  to  assess  manufacturer  compliance  with  MDRP  reporting  requirements.  If  we  fail  to  provide  information  timely  or  are  found  to  have  knowingly
submitted false information to the government, we may be subject to civil monetary penalties and other sanctions, including termination from the MDRP,
which  would  result  in  payment  not  being  available  for  our  covered  drugs  under  Medicaid.  Failure  to  make  necessary  disclosures  and/or  to  identify
overpayments could result in allegations against us under the Federal False Claims Act and other laws and regulations.

Federal law requires that a manufacturer that participates in the MDRP also participate in the Public Health Service’s 340B drug pricing program
(340B  program)  in  order  for  federal  funds  to  be  available  for  the  manufacturer’s  drugs  under  Medicaid.  We  participate  in  the  340B  program,  which  is
administered by the Health Resources and Services Administration (HRSA), and requires us to charge statutorily defined covered entities no more than the
340B “ceiling price” for our covered drugs. These 340B covered entities include a variety of community health clinics and other entities that receive health
services grants from the Public Health Service, as well as hospitals that serve a disproportionate share of low-income patients. The 340B ceiling price is
calculated  using  a  statutory  formula,  which  is  based  on  the  AMP  and  rebate  amount  for  the  covered  drug  as  calculated  under  the  MDRP.  In  general,
products subject to Medicaid price reporting and rebate liability are also subject to the 340B ceiling price calculation and discount requirement. We are
obligated to report 340B ceiling prices to HRSA on a quarterly basis, and HRSA publishes them to 340B covered entities. HRSA has finalized regulations
regarding  the  calculation  of  the  340B  ceiling  price  and  the  imposition  of  civil  monetary  penalties  on  manufacturers  that  knowingly  and  intentionally
overcharge covered entities for 340B-eligible drugs. HRSA has also finalized an administrative dispute resolution process through which 340B covered
entities may pursue claims against participating manufacturers for overcharges, and through which manufacturers may pursue claims against 340B covered
entities for engaging in unlawful diversion or duplicate discounting of 340B drugs.

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In order to be eligible to have drug products paid for with federal funds under Medicaid and purchased by certain federal agencies and grantees, we
also  participate  in  the  U.S.  Department  of  Veterans  Affairs  (VA)  Federal  Supply  Schedule  (FSS)  pricing  program.  Under  the  VA/FSS  program,  we  are
obligated to report the Non-Federal Average Manufacturer Price (Non-FAM”) for our covered drugs to the VA and charge certain federal agencies no more
than the Federal Ceiling Price, which is calculated based on Non-FAMP using a statutory formula. These four agencies are the VA, the U.S. Department of
Defense, the U.S. Coast Guard, and the U.S. Public Health Service (including the Indian Health Service). We are also required to pay rebates on products
purchased by military personnel and dependents through the TRICARE retail pharmacy program. If we fail to provide timely information or are found to
have knowingly submitted false information, we may be subject to civil monetary penalties.

Individual states continue to consider and have enacted legislation to limit the growth of healthcare costs, including the cost of prescription drugs
and combination products. A number of states have either implemented or are considering implementation of drug price transparency legislation that may
prevent or limit our ability to take price increases at certain rates or frequencies. Requirements under such laws include advance notice of planned price
increases,  reporting  price  increase  amounts  and  factors  considered  in  taking  such  increases,  wholesale  acquisition  cost  information  disclosure  to
prescribers, purchasers, and state agencies, and new product notice and reporting. Such legislation could limit the price or payment for IBSRELA and, if
launched,  XPHOZAH,  and  a  number  of  states  are  authorized  to  impose  civil  monetary  penalties  or  pursue  other  enforcement  mechanisms  against
manufacturers who fail to comply with drug price transparency requirements, including the untimely, inaccurate, or incomplete reporting of drug pricing
information. If we are found to have violated state law requirements, we may become subject to penalties or other enforcement mechanisms, which could
have a material adverse effect on our business.

Pricing  and  rebate  calculations  are  complex,  vary  among  products  and  programs,  and  are  often  subject  to  interpretation  by  us,  governmental  or
regulatory  agencies,  and  the  courts.  The  terms,  scope  and  complexity  of  these  government  pricing  programs  change  frequently,  as  do  interpretations  of
applicable  requirements  for  pricing  and  rebate  calculations.  Responding  to  current  and  future  changes  may  increase  our  costs  and  the  complexity  of
compliance  will  be  time  consuming.  Any  required  refunds  to  the  U.S.  government  or  responding  to  a  government  investigation  or  enforcement  action
would  be  expensive  and  time  consuming  and  could  have  a  material  adverse  effect  on  our  business,  results  of  operations  and  financial  condition.  Price
recalculations  under  the  MDRP  also  may  affect  the  ceiling  price  at  which  we  are  required  to  offer  products  under  the  340B  program.  Civil  monetary
penalties can be applied if we are found to have knowingly submitted any false price or product information to the government, if we fail to submit the
required price data on a timely basis, or if we are found to have charged 340B covered entities more than the statutorily mandated ceiling price. In the event
that  CMS  were  to  terminate  our  Medicaid  rebate  agreement,  no  federal  payments  would  be  available  under  Medicaid  or  Medicare  for  IBSRELA  or,  if
launched, XPHOZAH. We cannot offer any assurances that our submissions will not be found to be incomplete or incorrect.

Risks Related to Intellectual Property

Our success will depend on our ability to obtain, maintain and protect our intellectual property rights.

Our success and ability to compete depend in part on our ability to obtain, maintain and enforce issued patents, trademarks and other intellectual property
rights  and  proprietary  technology  in  the  U.S.  and  elsewhere.  If  we  cannot  adequately  obtain,  maintain  and  enforce  our  intellectual  property  rights  and
proprietary  technology,  competitors  may  be  able  to  use  our  technologies  or  the  goodwill  we  have  acquired  in  the  marketplace  and  erode  or  negate  any
competitive advantage we may have and our ability to compete, which could harm our business and ability to achieve profitability and/or cause us to incur
significant expenses.

We rely on a combination of contractual provisions, confidentiality procedures and patent, trademark, copyright, trade secret and other intellectual property
laws to protect the proprietary aspects of our products, product candidates, brands, technologies, trade secrets, know-how and data. These legal measures
afford only limited protection, and competitors or others may gain access to or use our intellectual property rights and proprietary information. Our success
will depend, in part, on preserving our trade secrets, maintaining the security of our data and know-how and obtaining, maintaining and enforcing other
intellectual  property  rights.  We  may  not  be  able  to  obtain,  maintain  and/or  enforce  our  intellectual  property  or  other  proprietary  rights  necessary  to  our
business or in a form that provides us with a competitive advantage.

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Failure to obtain, maintain and/or enforce intellectual property rights necessary to our business and failure to protect, monitor and control the use of our
intellectual property rights could negatively impact our ability to compete and cause us to incur significant expenses. The intellectual property laws and
other  statutory  and  contractual  arrangements  in  the  U.S.  and  other  jurisdictions  we  depend  upon  may  not  provide  sufficient  protection  in  the  future  to
prevent the infringement, use, violation, or misappropriation of our patents, trademarks, data, technology, and other intellectual property rights and products
by others; and may not provide an adequate remedy if our intellectual property rights are infringed, misappropriated, or otherwise violated by others.

We rely in part on our portfolio of issued and pending patent applications in the U.S. and other countries to protect our intellectual property and competitive
position. However, it is also possible that we may fail to identify patentable aspects of inventions made in the course of our development, manufacture and
commercialization activities before it is too late to obtain patent protection on them. If we fail to timely file for patent protection in any jurisdiction, we
may  be  precluded  from  doing  so  at  a  later  date.  Although  we  enter  into  non-disclosure  and  confidentiality  agreements  with  parties  who  have  access  to
patentable  aspects  of  our  research  and  development  output,  such  as  our  employees,  corporate  collaborators,  outside  scientific  collaborators,  suppliers,
consultants, advisors, and other third parties, any of these parties may breach the agreements and disclose such output before a patent application is filed,
thereby jeopardizing our ability to seek patent protection. Furthermore, publications of discoveries in the scientific literature often lag behind the actual
discoveries, and patent applications in the U.S. and other jurisdictions are typically not published until 18 months after filing, or in some cases not at all.
Therefore, we cannot be certain that we were the first to make the inventions claimed in any of our patents or pending patent applications, or that we were
the first to file for patent protection of such inventions. Moreover, should we become a licensee of a third party’s patents or patent applications, depending
on the terms of any future in-licenses to which we may become a party, we may not have the right to control the preparation, filing and prosecution of
patent  applications,  or  to  maintain  or  enforce  the  patents,  covering  technology  in-licensed  from  third  parties.  Therefore,  these  patents  and  patent
applications may not be prosecuted, maintained and/or enforced in a manner consistent with the best interests of our business. Any of these outcomes could
impair our ability to prevent competition from third parties, which may have an adverse impact on our business.

The  patent  positions  of  companies,  including  our  patent  position,  may  involve  complex  legal  and  factual  questions  that  have  been  the  subject  of  much
litigation in recent years, and, therefore, the scope of any patent claims that we have or may obtain cannot be predicted with certainty. Accordingly, we
cannot provide any assurances about which of our patent applications will issue, the breadth of any resulting patent, whether any of the issued patents will
be found to be infringed, invalid or unenforceable or will be threatened or challenged by third parties, that any of our issued patents have, or that any of our
currently  pending  or  future  patent  applications  that  mature  into  issued  patents  will  include,  claims  with  a  scope  sufficient  to  protect  our  products  and
services. Our pending and future patent applications may not result in the issuance of patents or, if issued, may not issue in a form that will be advantageous
to us. The coverage claimed in a patent application can be significantly reduced before the patent is issued, and its scope can be reinterpreted after issuance.
We  cannot  offer  any  assurances  that  the  breadth  of  our  granted  patents  will  be  sufficient  to  stop  a  competitor  from  developing,  manufacturing  and
commercializing  a  product  or  technologies  in  a  non-infringing  manner  that  would  be  competitive  with  one  or  more  of  our  products  or  technologies,  or
otherwise provide us with any competitive advantage. Furthermore, any successful challenge to these patents or any other patents owned by or licensed to
us after patent issuance could deprive us of rights necessary for our commercial success. Further, there can be no assurance that we will have adequate
resources to enforce our patents.

Patents have a limited lifespan. In the U.S., the natural expiration of a utility patent is generally 20 years from the earliest effective non-provisional filing
date. Though an issued patent is presumed valid and enforceable, its issuance is not conclusive as to its validity or its enforceability and it may not provide
us  with  adequate  proprietary  protection  or  competitive  advantages  against  competitors  with  similar  products  or  services.  Patents,  if  issued,  may  be
challenged, deemed unenforceable, invalidated, narrowed or circumvented. Proceedings challenging our patents or patent applications could result in either
loss of the patent, or denial of the patent application or loss or reduction in the scope of one or more of the claims of the patent or patent application. Any
successful  challenge  to  our  patents  and  patent  applications  could  deprive  us  of  exclusive  rights  necessary  for  our  commercial  success.  In  addition,
defending  such  challenges  in  such  proceedings  may  be  costly.  Thus,  any  patents  that  we  may  own  may  not  provide  the  anticipated  level  of,  or  any,
protection against competitors. Furthermore, an adverse decision may result in a third party receiving a patent right sought by us, which in turn could affect
our ability to develop, manufacture or commercialize our products or technologies.

Some of our patents and patent applications may in the future be co-owned with third parties. If we are unable to obtain an exclusive license to any such
third-party co-owners’ interest in such patents or patent applications, such co-owners may be able to license their rights to other third parties, including our
competitors, and our competitors could market competing products, services and technology. In addition, we may need the cooperation of any such co-
owners of our patents in order to enforce such patents against third parties, and such cooperation may not be provided to us.

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The degree of future protection for our proprietary rights is uncertain, and we cannot ensure that:

• Any of our patents, or any of our pending patent applications, if issued, will include claims having a scope sufficient to protect our products or product

candidates;

• Any of our pending patent applications will issue as patents;

• We were the first to make the inventions covered by each of our patents and pending patent applications;

• We were the first to file patent applications for these inventions;

• Others will not develop, manufacture and/or commercialize similar or alternative products or technologies that do not infringe our patents;

• Any of our challenged patents will ultimately be found to be valid and enforceable;

• Any patents issued to us will provide a basis for an exclusive market for our commercially viable products or technologies will provide us with any

competitive advantages or will not be challenged by third parties;

• We will develop additional proprietary technologies or products that are separately patentable; or

• Our commercial activities or products will not infringe upon the patents of others.

We may become subject to third-party claims alleging infringement, misappropriation or violation of such third parties’ patents or other intellectual
property rights and/or third-party claims seeking to invalidate our patents, which would be costly, time consuming and, if successfully asserted against
us, delay or prevent the development, manufacture or commercialization of our products or product candidates.

Our commercial success depends, in part, on our ability to develop, manufacture or commercialize our products and product candidates without infringing,
misappropriating  or  otherwise  violating  the  intellectual  property  rights  of  third  parties.  There  have  been  many  lawsuits  and  other  proceedings  asserting
infringement or misappropriation of patents and other intellectual property rights in the pharmaceutical and biotechnology industries, and companies in the
industry  have  used  intellectual  property  litigation  to  gain  a  competitive  advantage.  While  we  take  steps  to  ensure  that  we  do  not  infringe  upon,
misappropriate or otherwise violate the intellectual property rights of others, there can be no assurances that we will not be subject to claims alleging that
the manufacture, use or sale of IBSRELA or XPHOZAH or of any other product candidates infringes existing or future third-party patents, or that such
claims, if any, will not be successful. Because patent applications can take many years to issue and may be confidential for 18 months or more after filing,
and because pending patent claims can be revised before issuance, there may be applications now pending which may later result in issued patents that may
be infringed by the manufacture, use or sale of IBSRELA or XPHOZAH or other product candidates. Moreover, we may face patent infringement claims
from non-practicing entities that have no relevant product revenue and against whom our own patent portfolio may thus have no deterrent effect. We may
be  unaware  of  one  or  more  issued  patents  that  would  be  infringed  by  the  manufacture,  sale  or  use  of  IBSRELA  or  XPHOZAH  or  our  other  product
candidates.

Third parties may initiate legal proceedings alleging that we are infringing, misappropriating or otherwise violating their intellectual property rights. These
proceedings  could  cause  us  to  pay  substantial  damages,  including  treble  damages  and  attorney’s  fees  if  we  are  found  to  be  willfully  infringing  a  third
party’s patents. We may be required to indemnify future collaboration partners against such claims. We are not aware of any threatened or pending claims
related to these matters, but in the future, litigation may be necessary to defend against such claims. If a patent infringement suit were brought against us,
we could be forced to stop or delay development, manufacturing or sales of the product or product candidate that is the subject of the suit. As a result of
patent infringement claims, or in order to avoid potential claims, we may choose to seek, or be required to seek, a license from the third party and would
most likely be required to pay license fees or royalties or both. These licenses may not be available on acceptable terms, or at all. Even if we were able to
obtain a license, we may be unable to maintain such licenses and the rights may be nonexclusive, which would give our competitors access to the same
intellectual property. Ultimately, we could be prevented from commercializing a product, or forced to redesign it if, as a result of actual or threatened patent
infringement claims, we are unable to enter into licenses on acceptable terms, or unable to maintain such licenses when granted. Even if we are successful
in defending against such claims, such litigation can be expensive and time consuming to litigate and would divert management’s attention from our core
business. Any of these events could harm our business significantly.

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We also could be ordered to pay substantial damages, including treble damages and attorney’s fees if we are found to be willfully infringing a third party’s
patents or other intellectual property right. Even if we believe such claims are without merit, a court of competent jurisdiction could hold that these third
party  patents  are  valid  and  enforceable,  and  infringed  by  the  use  of  our  products  and/or  technologies,  which  could  have  a  negative  impact  on  the
commercial  success  of  our  current  and  any  future  products  or  technologies.  If  we  were  to  challenge  the  validity  of  any  such  third  party  U.S.  patent  in
federal court, we would need to overcome a presumption of validity. As this burden is a high one requiring us to present clear and convincing evidence as
to the invalidity of any such U.S. patent claim, there is no assurance that a court of competent jurisdiction would invalidate the claims of any such U.S.
patent. We will have similar burdens to overcome in foreign courts in order to successfully challenge a third party claim of patent infringement. Even if we
are successful in defending against such claims, such litigation can be expensive and time consuming to litigate and would divert management’s attention
from our core business. Any of these events could harm our business significantly.

In  addition  to  infringement  claims  against  us,  third  parties  may  also  raise  similar  claims  before  administrative  bodies  in  the  U.S.  or  abroad.  Such
mechanisms  include  reexamination,  post  grant  review,  inter  parties  review,  derivation  or  opposition  proceedings  before  the  United  States  Patent  and
Trademark  Office  (USPTO)  or  other  jurisdictional  body  relating  to  our  intellectual  property  rights  or  the  intellectual  property  rights  of  others.  If  third
parties prepare and file patent applications in the U.S. that also claim technology similar or identical to ours, we may have to participate in interference or
derivation proceedings in the USPTO to determine which party is entitled to a patent on the disputed invention. We may also become involved in similar
opposition proceedings in the European Patent Office or similar offices in other jurisdictions regarding our intellectual property rights with respect to our
products and technology. Since patent applications are confidential for a period of time after filing, we cannot be certain that we were the first to file any
patent application related to our product candidates. Such administrative proceedings could result in revocation of or amendment to our patents in such a
way that they no longer cover our products or product candidates. With respect to the validity question, for example, we cannot be certain that there is no
invalidating prior art, of which we, our patent counsel, and the patent examiner were unaware during prosecution. If a third party were to prevail on a legal
assertion of invalidity and/or unenforceability, we may lose at least part, and perhaps all, of the patent protection on our products or technologies. Such a
loss of patent protection would have a material adverse impact on our business, financial condition, results of operations, and prospects.

If we are not able to successfully enforce our intellectual property rights, the commercial value of IBSRELA, XPHOZAH, RDX013 or other product
candidates may be adversely affected and we may not be able to compete effectively in our market.

The enforceability of patents in the biotechnology and pharmaceutical field involves complex legal and scientific questions, the answers to which can be
uncertain. The patent applications that we own or license may fail to result in issued patents in the U.S. or in foreign countries. Additionally, our research
and development efforts may result in product candidates for which patent protection is limited or not available. Even if patents do issue, third parties may
challenge the validity, enforceability, scope or infringement thereof, which may result in such patents being narrowed, invalidated, held unenforceable or
not infringed. For example, U.S. patents can be challenged by any person before the new USPTO Patent Trial and Appeals Board at any time before one
year after that person is served an infringement complaint based on the patents. Patents granted by the European Patent Office may be similarly opposed by
any person within nine months from the publication of the grant. Similar proceedings are available in other jurisdictions, and in the U.S., Europe and other
jurisdictions  third  parties  can  raise  questions  of  validity  with  a  patent  office  even  before  a  patent  has  granted.  Furthermore,  even  if  unchallenged,  our
patents and patent applications may not prevent others from designing around our patent claims. For example, a third party may develop a competitive
product that provides therapeutic benefits similar to one or more of our product candidates but has a sufficiently different composition to fall outside the
scope of our patent protection. If the breadth or strength of protection provided by the patents and patent applications we hold or pursue with respect to
IBSRELA,  XPHOZAH,  RDX013  or  any  future  product  candidates  is  successfully  challenged,  then  our  ability  to  commercialize  such  product  could  be
negatively affected, and we may face unexpected competition that could have a material adverse impact on our business. Further, we have reported that we
have completed the data analysis from our Phase 2 clinical trial evaluating the safety and efficacy of RDX013 for the treatment of hyperkalemia, and that
we currently expect that the next steps for the RDX013 program will be to evaluate a new formulation that potentially enhances subject compliance and the
efficacy  of  RDX013  in  an  additional  Phase  2  clinical  study.  We  currently  expect  to  delay  further  development  of  RDX013  until  such  time  as  we  have
determined that our available resources support conducting such additional formulation work and an additional clinical study. As a result of this delay in
our development program for RDX013, the period of time during which we or our collaboration partners could market RDX013 under patent protection
could be reduced.

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Even  where  laws  provide  intellectual  property  and/or  regulatory  protection,  costly  and  time-consuming  litigation  could  be  necessary  to  enforce  and
determine the scope of our proprietary rights, and the outcome of such litigation would be uncertain. If we or one of our collaboration partners were to
initiate legal proceedings against a third party to enforce a patent covering a product or product candidate, the defendant could counterclaim that our patent
is  invalid,  unenforceable  and/or  not  infringed.  In  patent  litigation  in  the  U.S.  and  other  jurisdictions,  defendant  counterclaims  alleging  invalidity,
unenforceability and/or noninfringement are commonplace. Grounds for a validity challenge could be an alleged failure to meet any of several statutory
requirements, including novelty, nonobviousness and enablement. Grounds for an unenforceability assertion could be an allegation that someone connected
with prosecution of the patent withheld relevant information from the USPTO, or made a misleading statement, during prosecution. The outcome following
legal assertions of invalidity, unenforceability and noninfringment is unpredictable. With respect to validity, for example, we cannot be certain that there is
no  invalidating  prior  art,  of  which  we  and  the  patent  examiner  were  unaware  during  prosecution.  If  a  defendant  were  to  prevail  on  a  legal  assertion  of
invalidity, unenforceability or non-infringement of our intellectual property related to a product or a product candidate, we could lose part, and possibly all,
of  the  patent  protection  on  such  product  or  product  candidate.  Such  a  loss  of  patent  protection  could  have  a  material  adverse  impact  on  our  business.
Moreover, our competitors could counterclaim that we infringe their intellectual property and may attempt to prevent us from commercializing a product.

Although the composition and use of IBSRELA are currently claimed by four (4) issued patents that are listed in the U.S. FDA’s Orange Book, we cannot
assure that we will be successful in defending against third parties asserting that any of our patents are invalid, unenforceable or not infringed by the third
parties’ products, or in competing against third parties seeking to introduce generic versions of IBSRELA or any of our future products.

In  the  U.S.,  the  Hatch-Waxman  Act  provides  non-patent  regulatory  exclusivity  for  five  years  from  the  date  of  the  first  U.S.  FDA  approval  of  a  drug
containing  a  new  chemical  entity  (NCE).  The  U.S.  FDA  is  prohibited  during  those  five  years  from  approving  an  Abbreviated  New  Drug  Application
(ANDA) that references the NDA that has been granted NCE exclusivity. However, if any patents are listed in the U.S. FDA Orange Book for such NCE-
containing drug, a generic manufacturer may file an ANDA that references a NDA product with granted NCE exclusivity after four years from the first
NDA approval date provided it is accompanied by a Paragraph IV certification asserting that each Orange Book listed patent is invalid, unenforceable, or
that the generic product does not infringe the Orange Book listed patents. The Hatch-Waxman Act does not prevent a third party from filing, or the U.S.
FDA from approving, another full NDA (i.e. not an ANDA) for an already-approved drug where the third party has conducted its own pre-clinical and
clinical trials to independently demonstrate safety and effectiveness without reliance on the original NDA data.

In cases where NCE exclusivity has been granted for an NDA, as in the case of IBSRELA, if an ANDA sponsor has provided a Paragraph IV certification
to the U.S. FDA when filing an ANDA, the ANDA sponsor must also send a notice thereof to the NCE NDA owner. The NCE NDA owner may then
initiate a patent infringement lawsuit in response to the Paragraph IV certification. The filing of a patent infringement lawsuit within 45 days after the NCE
NDA owner’s receipt of a notice of the Paragraph IV certification automatically prevents the U.S. FDA from approving the ANDA until the earlier of 30
months after the NCE NDA owner’s receipt of the Paragraph IV certification notice or a final decision in the infringement case in favor of the ANDA
sponsor. There can be no assurances that an ANDA that references our IBSRELA NDA and includes a Paragraph IV certification will not be filed, or that
we will be successful in enforcing our Orange Book listed patents against such ANDA sponsor.

We also rely on trade secret protection and confidentiality agreements to protect proprietary know-how that may not be patentable, processes for which
patents may be difficult to obtain and/or enforce and any other elements of our drug discovery and development processes that involve proprietary know-
how, information or technology that is not covered by patents. Although we require all of our employees, consultants, advisors and any third parties who
have access to our proprietary know-how, information or technology, to assign their inventions to us, and endeavor to execute confidentiality agreements
with all such parties, we cannot be certain that we have executed such agreements with all parties who may have helped to develop our intellectual property
or who had access to our proprietary information, nor can we be certain that our agreements will not be breached by such consultants, advisors or third
parties, or by our former employees. The breach of such agreements by individuals or entities who were actively involved in the discovery and design of
our products or potential drug candidates, or in the development of our discovery and design platform could require us to pursue legal action to protect our
trade  secrets  and  confidential  information,  which  could  be  expensive,  and  the  outcome  of  which  would  be  unpredictable.  If  we  are  not  successful  in
prohibiting  the  continued  breach  of  such  agreements,  our  business  could  be  negatively  impacted.  We  cannot  guarantee  that  our  trade  secrets  and  other
confidential proprietary information will not be disclosed or that competitors will not otherwise gain access to our trade secrets or independently develop
substantially equivalent information and techniques.

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Further, the laws of some foreign countries do not protect proprietary rights to the same extent or in the same manner as the laws of the U.S. As a result, we
may encounter significant problems in protecting and defending our intellectual property both in the U.S. and abroad. If we are unable to prevent material
disclosure of the intellectual property related to our technologies to third parties, we will not be able to establish or maintain a competitive advantage in our
market, which could materially adversely affect our business, results of operations and financial condition.

Although we have obtained patent term extension in the U.S. under the Hatch-Waxman Act, extending the term of exclusivity for tenapanor, if we do
not obtain patent term extension in foreign countries under similar legislation, our business may be materially harmed. Furthermore, we have obtained
patent term adjustment in the U.S. under the American Inventors Protection Act extending the patent term for certain patents covering tenapanor.

U.S. Patent No. 8,541,448 covering tenapanor was subject to patent term adjustment (PTA) under the American Inventors Protection Act for delays by the
United States Patent and Trademark Office in granting the patent. Additionally, following the approval by the U.S. FDA for our NDA to market tenapanor
for  IBS-C,  this  patent  was  granted  patent  term  extension  (PTE)  under  the  Hatch-Waxman  Act  and  together  with  PTA  provides  us  with  exclusivity  for
tenapanor and uses thereof until August 1, 2033. The Hatch-Waxman Act allows a maximum of one patent to be extended per U.S. FDA approved product.
Extension and/or adjustment of patent term (collectively “Patent Restoration”) also may be available in certain foreign countries upon regulatory approval
of  our  product  candidates.  Despite  seeking  Patent  Restoration  for  tenapanor  in  all  countries  where  it  is  available,  it  may  not  be  granted  in  any  foreign
country because of, for example, failing to apply within applicable deadlines, failing to apply prior to expiration of relevant patents or otherwise failing to
satisfy applicable requirements. Moreover, the term of patent protection subject to Patent Restoration, as well as the scope of patent protection during any
such  Patent  Restoration,  afforded  by  the  governmental  authority  could  be  less  than  we  request  or  could  change  due  to  changes  to  applicable  Patent
Restoration laws or regulations or interpretations thereof.

If we are unable to obtain Patent Term Restoration in any particular country, or the term of any such extension is less than we request, or is changed due to
changes in applicable laws or regulations or interpretations thereof, the period during which we will have exclusive rights to our product in such country
could  be  shortened  and  our  competitors  may  obtain  approval  of  competing  products  following  our  non-extended/adjusted  patent  expiration,  and  our
revenue could be reduced, possibly materially.

The  USPTO  and  various  foreign  patent  agencies  require  compliance  with  a  number  of  procedural,  documentary,  fee  payment  and  other  provisions  to
maintain  patent  applications  and  issued  patents.  Noncompliance  with  these  requirements  can  result  in  abandonment  or  lapse  of  a  patent  or  patent
application, resulting in partial or complete loss of patent rights in the relevant jurisdiction. In such an event, competitors might be able to enter the market
earlier than would otherwise have been the case.

We may not be able to enforce our intellectual property rights throughout the world.

The laws of some foreign countries do not protect intellectual property rights to the same extent as the laws of the U.S. Many companies have encountered
significant  problems  in  protecting  and  defending  intellectual  property  rights  in  certain  foreign  jurisdictions.  The  legal  systems  of  some  countries,
particularly  developing  countries,  do  not  favor  the  enforcement  of  patents  and  other  intellectual  property  protection,  especially  those  relating  to  life
sciences. This could make it difficult for us to stop the infringement of our patents or the misappropriation of our other intellectual property rights. For
example, many foreign countries have compulsory licensing laws under which a patent owner must grant licenses to third parties.

Europe’s new Unified Patent Court may, in particular, present uncertainties for our ability to protect and enforce our patent rights against competitors in
Europe.  In  2012,  the  European  Patent  Package  (EU  Patent  Package)  regulations  were  passed  with  the  goal  of  providing  a  single  pan-European  Unitary
Patent and a new European Unified Patent Court (UPC), for litigation involving European patents. Implementation of the EU Patent Package entered into
force on June 1, 2023. Under the UPC, all European patents, including those issued prior to ratification of the European Patent Package, will by default
automatically fall under the jurisdiction of the UPC. The UPC will provide our competitors with a new forum to centrally revoke our European patents and
allow for the possibility of a competitor to obtain pan-European injunctions. It will be several years before we will understand the scope of patent rights
that will be recognized and the strength of patent remedies that will be provided by the UPC. Under the EU Patent Package as currently proposed, we will
have the right to opt our patents out of the UPC over the first seven years of the court’s existence, but doing so may preclude us from realizing the benefits
of the new unified court.

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In  addition,  geo-political  actions  in  the  United  States  and  in  foreign  countries  could  increase  the  uncertainties  and  costs  surrounding  the  prosecution  or
maintenance of our patent applications or those of any current or future licensors and the maintenance, enforcement or defense of our issued patents or
those of any current or future licensors. For example, the United States and foreign government actions related to Russia’s conflict in Ukraine may limit or
prevent  filing,  prosecution,  and  maintenance  of  patent  applications  in  Russia.  Government  actions  may  also  prevent  maintenance  of  issued  patents  in
Russia. These actions could result in abandonment or lapse of our patents or patent applications, resulting in partial or complete loss of patent rights in
Russia. In addition, a decree was adopted by the Russian government in March 2022, allowing Russian companies and individuals to exploit inventions
owned by patentees from the United States without consent or compensation. Consequently, we would not be able to prevent third parties from practicing
our inventions in Russia or from selling or importing products made using our inventions in and into Russia. Accordingly, our competitive position may be
impaired, and our business, financial condition, results of operations and prospects may be adversely affected.

Proceedings  to  enforce  our  patent  rights  in  foreign  jurisdictions,  whether  or  not  successful,  could  result  in  substantial  costs  and  divert  our  efforts  and
attention from other aspects of our business. Furthermore, while we intend to protect our intellectual property rights in our expected significant markets, we
cannot ensure that we will be able to initiate or maintain similar efforts in all jurisdictions in which we may wish to market our products. Accordingly, our
efforts to protect our intellectual property rights in such countries may be inadequate. In addition, changes in the law and legal decisions by courts in the
U.S. and foreign countries may affect our ability to obtain and enforce adequate intellectual property protection for our technology.

We may be subject to claims that we or our employees have misappropriated the intellectual property, including know-how or trade secrets, of a third
party, or claiming ownership of what we regard as our own intellectual property.

Many  of  our  employees,  consultants  and  contractors  were  previously  employed  at  or  engaged  by  other  biotechnology  or  pharmaceutical  companies,
including our competitors or potential competitors. Some of these employees, consultants and contractors, executed proprietary rights, non-disclosure and
non-competition agreements in connection with such previous employment. Although we try to ensure that our employees, consultants and contractors do
not use the intellectual property and other proprietary information or know-how or trade secrets of others in their work for us, and do not perform work for
us that is in conflict with their obligations to another employer or any other entity, we may be subject to claims that we or these employees, consultants and
contractors have used or disclosed such intellectual property, including know-how, trade secrets or other proprietary information. In addition, an employee,
advisor or consultant who performs work for us may have obligations to a third party that are in conflict with their obligations to us, and as a result such
third party may claim an ownership interest in the intellectual property arising out of work performed for us. We are not aware of any threatened or pending
claims related to these matters, but in the future litigation may be necessary to defend against such claims. If we fail to defend any such claims, in addition
to  paying  monetary  damages,  we  may  lose  valuable  intellectual  property  rights  or  personnel,  or  access  to  consultants  and  contractors.  Even  if  we  are
successful in defending against such claims, litigation could result in substantial costs and be a distraction to management.

In  addition,  while  we  typically  require  our  employees,  consultants  and  contractors  who  may  be  involved  in  the  development  of  intellectual  property  to
execute  agreements  assigning  such  intellectual  property  to  us,  we  may  be  unsuccessful  in  executing  such  an  agreement  with  each  party  who  in  fact
develops intellectual property that we regard as our own, which may result in claims by or against us related to the ownership of such intellectual property.
If we fail in prosecuting or defending any such claims, in addition to paying monetary damages, we may lose valuable intellectual property rights. Even if
we are successful in prosecuting or defending against such claims, litigation could result in substantial costs and be a distraction to our management and
scientific personnel.

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Risks Related to Our Common Stock

Our stock price may continue to be volatile and our stockholders may not be able to resell shares of our common stock at or above the price they paid.

The trading price of our common stock is highly volatile and could be subject to wide fluctuations in response to various factors, some of which are beyond
our control. These factors include those discussed in this “Risk Factors” section and others such as:

•

•

•

•

•

•

•

•

•

•

•

•

•

•

the success or lack of success with regards to our commercialization of IBSRELA and XPHOZAH;

results of regulatory inspections of our facilities or those of our CMOs, or specific label restrictions or patient populations for XPHOZAH’s use, or
changes or delays in the regulatory review process;

announcements regarding whether XPHOZAH alone or with other oral only medications, will be included in the ESRD PPS, and the time and manner
in which such transition is achieved;

announcements relating to our current or future collaboration partnerships;

announcements of therapeutic innovations or new products by us or our competitors;

adverse actions taken by regulatory agencies with respect to our product label, our clinical trials, manufacturing supply chain or sales and marketing
activities;

changes or developments in laws or regulations applicable to our approved products or our product candidates;

the success of our testing and clinical trials;

failure to meet any of our projected timelines or goals with regard to the commercialization of IBSRELA and XPOHZAH, or the clinical development
and commercialization of any of our product candidates;

the success of our efforts to acquire or license or discover additional product candidates;

any intellectual property infringement actions in which we may become involved;

the success of our efforts to obtain adequate intellectual property protection for our product candidates;

announcements concerning our competitors or the pharmaceutical industry in general;

achievement of expected product sales and profitability;

• manufacture, supply or distribution shortages;

•

actual or anticipated fluctuations in our operating results;

• U.S. FDA or other U.S. or foreign regulatory actions affecting us or our industry or other healthcare reform measures in the U.S.;

•

•

•

•

•

•

changes in financial estimates or recommendations by securities analysts;

trading volume of our common stock;

sales of our common stock by us, our executive officers and directors or our stockholders in the future;

sales of debt securities and sales or licensing of assets;

general economic and market conditions and overall fluctuations in the U.S. equity markets; and

the loss of any of our key scientific or management personnel.

In addition, the stock markets in general, and the markets for pharmaceutical, biopharmaceutical and biotechnology stocks in particular, have experienced
extreme  volatility  that  may  have  been  unrelated  to  the  operating  performance  of  the  issuer.  These  broad  market  fluctuations  may  adversely  affect  the
trading  price  or  liquidity  of  our  common  stock.  In  the  past,  when  the  market  price  of  a  stock  has  been  volatile,  holders  of  that  stock  have  sometimes
instituted securities class action litigation against the issuer. If any of our stockholders were to bring such a lawsuit against us, we could incur substantial
costs defending the lawsuit and the attention of our management would be diverted from the operation of our business, which could seriously harm our
financial position. Any adverse determination in litigation could also subject us to significant liabilities.

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If  we  sell  shares  of  our  common  stock  in  future  financings,  stockholders  may  experience  immediate  dilution  and,  as  a  result,  our  stock  price  may
decline.

We may from time to time issue additional shares of common stock at a discount from the current trading price of our common stock. As a result, our
stockholders would experience immediate dilution upon the purchase of any shares of our common stock sold at such discount. In addition, as opportunities
present themselves, we may enter into financing or similar arrangements in the future, including the issuance of debt securities, preferred stock or common
stock. If we issue common stock or securities convertible into common stock, our common stockholders will experience additional dilution and, as a result,
our stock price may decline.

We  will  no  longer  be  a  “smaller  reporting  company”  in  2024  and  as  a  result  we  are  or  will  be  subject  to  certain  enhanced  disclosure  requirements
which will require us to incur significant expenses and expend time and resources.

We will no longer be a “smaller reporting company,” in 2024 and, as a result, we are or will be required to comply with various disclosure and compliance
requirements that did not previously apply to us. Compliance with these additional requirements increases our legal and financial compliance costs and
causes  management  and  other  personnel  to  divert  attention  from  operational  and  other  business  matters  to  these  additional  public  company  reporting
requirements. In addition, if we are not able to comply with changing requirements in a timely manner, the market price of our stock could decline and we
could be subject to delisting proceedings by the Nasdaq Global Market, or sanctions or investigations by the Securities and Exchange Commission (SEC)
or other regulatory authorities, which would require additional financial and management resources.

We are not required to reflect the change in our smaller reporting company status and comply with the increased disclosure obligations until our quarterly
report for the quarter ending March 31, 2024, the first quarter in our fiscal year ending December 31, 2024. We will need to reassess, as of June 30, 2024,
whether we will continue to qualify as a large accelerated filer for filings beyond the fiscal year ending December 31, 2024.

General Risk Factors

We incur significant costs as a result of operating as a public company, and our management will devote substantial time to new compliance initiatives.
We may fail to comply with the rules that apply to public companies, including Section 404 of the Sarbanes-Oxley Act of 2002, which could result in
sanctions or other penalties that would harm our business.

We incur significant legal, accounting and other expenses as a public company, including costs resulting from public company reporting obligations under
the Securities Exchange Act of 1934, as amended (Exchange Act) and regulations regarding corporate governance practices. The listing requirements of
The  Nasdaq  Global  Market  require  that  we  satisfy  certain  corporate  governance  requirements  relating  to  director  independence,  distributing  annual  and
interim  reports,  stockholder  meetings,  approvals  and  voting,  soliciting  proxies,  conflicts  of  interest  and  a  code  of  conduct.  Our  management  and  other
personnel will need to devote a substantial amount of time to ensure that we comply with all of these requirements. Moreover, the reporting requirements,
rules and regulations will increase our legal and financial compliance costs and will make some activities more time consuming and costly. Any changes
we make to comply with these obligations may not be sufficient to allow us to satisfy our obligations as a public company on a timely basis, or at all. These
reporting requirements, rules and regulations, coupled with the increase in potential litigation exposure associated with being a public company, could also
make it more difficult for us to attract and retain qualified persons to serve on our board of directors or board committees or to serve as executive officers,
or to obtain certain types of insurance, including directors’ and officers’ insurance, on acceptable terms.

We are subject to Section 404 of The Sarbanes-Oxley Act of 2002 (Section 404) and the related rules of the SEC which generally require, among other
things, our management and independent registered public accounting firm to report on the effectiveness of our internal control over financial reporting.
Our compliance with Section 404 requires that we incur substantial expense and expend significant management efforts.

During the course of our review and testing of our internal controls, we may identify deficiencies and be unable to remediate them before we must provide
the required reports. Furthermore, if we have a material weakness in our internal controls over financial reporting, we may not detect errors on a timely
basis and our financial statements may be materially misstated. We or our independent registered public accounting firm may not be able to conclude on an
ongoing basis that we have effective internal control over financial reporting, which could harm our operating results, cause investors to lose confidence in
our reported financial information and cause the trading price of our stock to fall. In addition, as a public company we are required to file accurate and
timely quarterly and annual reports with the SEC under the Exchange Act. Any failure to report our financial results on an accurate and timely basis could
result  in  sanctions,  lawsuits,  delisting  of  our  shares  from  The  Nasdaq  Global  Market  or  other  adverse  consequences  that  would  materially  harm  our
business.

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We may be adversely affected by the global economic environment.

Our ability to attract and retain collaboration partners or customers, invest in and grow our business and meet our financial obligations depends on our
operating and financial performance, which, in turn, is subject to numerous factors, including the prevailing economic conditions and financial, business
and other factors beyond our control, such as the rate of unemployment, the number of uninsured persons in the U.S., presidential elections, other political
influences and inflationary pressures. Our results of operations could be adversely affected by general conditions in the global economy and in the global
financial  markets,  including  the  current  inflationary  environment  and  rising  interest  rates.  Adverse  developments  that  affect  financial  institutions,
transactional counterparties, or other third parties, or concerns or rumors about these events, have in the past and may in the future lead to market-wide
liquidity  problems.  For  example,  on  March  10,  2023,  Silicon  Valley  Bank  (SVB)  was  closed  by  the  California  Department  of  Financial  Protection  and
Innovation, which appointed the U.S. Federal Deposit Insurance Corporation (FDIC) as receiver. Similarly, other institutions have been and may continue
to be swept into receivership. We currently have no borrowing or deposit exposure to directly impacted institutions and have not experienced an adverse
impact to our liquidity or to our business operations, financial condition, or results of operations as a result of these recent events. However, uncertainty
may remain over liquidity concerns in the broader financial services industry, and there may be unpredictable impacts to our business and our industry. We
cannot  anticipate  all  the  ways  in  which  the  global  economic  climate  and  global  financial  market  conditions  could  adversely  impact  our  business  in  the
future.

We  are  exposed  to  risks  associated  with  reduced  profitability  and  the  potential  financial  instability  of  our  collaboration  partners  or  customers,  many  of
which may be adversely affected by volatile conditions in the financial markets. For example, unemployment and underemployment, and the resultant loss
of insurance, may decrease the demand for healthcare services and pharmaceuticals. If fewer patients are seeking medical care because they do not have
insurance coverage, our collaboration partners or customers may experience reductions in revenues, profitability and/or cash flow that could lead them to
reduce their support of our programs or financing activities. If collaboration partners or customers are not successful in generating sufficient revenue or are
precluded from securing financing, they may not be able to pay, or may delay payment of, accounts receivable that are owed to us. In addition, volatility in
the financial markets could cause significant fluctuations in the interest rate and currency markets. We currently do not hedge for these risks. The foregoing
events,  in  turn,  could  adversely  affect  our  financial  condition  and  liquidity.  In  addition,  if  economic  challenges  in  the  U.S.  result  in  widespread  and
prolonged unemployment, either regionally or on a national basis, or if certain provisions of the Patient Protection and ACA, as amended by the Health
Care  and  Education  Reconciliation  Act,  collectively  known  as  the  ACA,  are  repealed,  a  substantial  number  of  people  may  become  uninsured  or
underinsured. To the extent economic challenges result in fewer individuals pursuing or being able to afford our product candidates once commercialized,
our business, results of operations, financial condition and cash flows could be adversely affected.

Provisions in our charter documents and under Delaware law could discourage a takeover that stockholders may consider favorable and may lead to
entrenchment of management.

Our amended and restated certificate of incorporation and amended and restated bylaws contain provisions that could significantly reduce the value of our
shares  to  a  potential  acquirer  or  delay  or  prevent  changes  in  control  or  changes  in  our  management  without  the  consent  of  our  board  of  directors.  The
provisions in our charter documents include the following:

•

•

•

•

•

•

a classified board of directors with three-year staggered terms, which may delay the ability of stockholders to change the membership of a majority of
our board of directors;

no cumulative voting in the election of directors, which limits the ability of minority stockholders to elect director candidates;

the exclusive right of our board of directors to elect a director to fill a vacancy created by the expansion of the board of directors or the resignation,
death or removal of a director, which prevents stockholders from being able to fill vacancies on our board of directors;

the required approval of at least two-thirds of the shares entitled to vote to remove a director for cause, and the prohibition on removal of directors
without cause;

the ability of our board of directors to authorize the issuance of shares of preferred stock and to determine the price and other terms of those shares,
including preferences and voting rights, without stockholder approval, which could be used to significantly dilute the ownership of a hostile acquirer;

the ability of our board of directors to alter our bylaws without obtaining stockholder approval;

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•

•

•

•

the required approval of at least two-thirds of the shares entitled to vote at an election of directors to adopt, amend or repeal our bylaws or repeal the
provisions of our amended and restated certificate of incorporation regarding the election and removal of directors;

a prohibition on stockholder action by written consent, which forces stockholder action to be taken at an annual or special meeting of our stockholders;

the requirement that a special meeting of stockholders may be called only by the chairman of the board of directors, the chief executive officer, the
president or the board of directors, which may delay the ability of our stockholders to force consideration of a proposal or to take action, including the
removal of directors; and

advance notice procedures that stockholders must comply with in order to nominate candidates to our board of directors or to propose matters to be
acted  upon  at  a  stockholders’  meeting,  which  may  discourage  or  deter  a  potential  acquirer  from  conducting  a  solicitation  of  proxies  to  elect  the
acquirer’s own slate of directors or otherwise attempting to obtain control of us.

In addition, these provisions would apply even if we were to receive an offer that some stockholders may consider beneficial.

We are also subject to the anti-takeover provisions contained in Section 203 of the Delaware General Corporation Law. Under Section 203, a corporation
may not, in general, engage in a business combination with any holder of 15% or more of its capital stock unless the holder has held the stock for three
years or, among other exceptions, the board of directors has approved the transaction.

Claims for indemnification by our directors and officers may reduce our available funds to satisfy successful third-party claims against us and may
reduce the amount of money available to us.

Our amended and restated certificate of incorporation and amended and restated bylaws provide that we will indemnify our directors and officers, in each
case to the fullest extent permitted by Delaware law.

In addition, as permitted by Section 145 of the Delaware General Corporation Law, our amended and restated bylaws and our indemnification agreements
that we have entered into with our directors and officers provide that:

• We will indemnify our directors and officers for serving us in those capacities or for serving other business enterprises at our request, to the fullest
extent permitted by Delaware law. Delaware law provides that a corporation may indemnify such a person if such person acted in good faith and in a
manner such person reasonably believed to be in or not opposed to the best interests of the registrant and, with respect to any criminal proceeding, had
no reasonable cause to believe such person’s conduct was unlawful.

• We may, in our discretion, indemnify employees and agents in those circumstances where indemnification is permitted by applicable law.

• We are required to advance expenses, as incurred, to our directors and officers in connection with defending a proceeding, except that such directors or

officers shall undertake to repay such advances if it is ultimately determined that such person is not entitled to indemnification.

• We  will  not  be  obligated  pursuant  to  our  amended  and  restated  bylaws  to  indemnify  a  person  with  respect  to  proceedings  initiated  by  that  person
against  us  or  our  other  indemnities,  except  with  respect  to  proceedings  authorized  by  our  board  of  directors  or  brought  to  enforce  a  right  to
indemnification.

•

The rights conferred in our amended and restated bylaws are not exclusive, and we are authorized to enter into indemnification agreements with our
directors, officers, employees and agents and to obtain insurance to indemnify such persons.

• We may not retroactively amend our amended and restated bylaw provisions to reduce our indemnification obligations to directors, officers, employees

and agents.

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We do not currently intend to pay dividends on our common stock, and, consequently, our stockholders’ ability to achieve a return on their investment
will depend on appreciation in the price of our common stock.

We do not currently intend to pay any cash dividends on our common stock for the foreseeable future. We currently intend to invest our future earnings, if
any, to fund our growth. Additionally, the terms of our 2022 Loan Agreement could restrict our ability to pay dividends. Therefore, our stockholders are not
likely  to  receive  any  dividends  on  our  common  stock  for  the  foreseeable  future.  Since  we  do  not  intend  to  pay  dividends,  our  stockholders’  ability  to
receive  a  return  on  their  investment  will  depend  on  any  future  appreciation  in  the  market  value  of  our  common  stock.  There  is  no  guarantee  that  our
common stock will appreciate or even maintain the price at which our holders have purchased it.

ITEM 1B.    UNRESOLVED STAFF COMMENTS

None.

ITEM 1C.    CYBERSECURITY

Cybersecurity Risk Management and Strategy

We have developed and implemented a cybersecurity program intended to manage risk, and protect the confidentiality, integrity, and availability of our
critical  systems  and  information.  Our  cybersecurity  program  includes  a  cybersecurity  incident  response  plan  as  well  as  key  technology  and  processes
required to monitor, alert and escalate in the event of malicious activity.

We design, assess and benchmark our program based on the National Institute of Standards and Technology Cybersecurity Framework (NIST CSF).

Our  cybersecurity  risk  management  program  is  integrated  into  our  overall  enterprise  risk  management  program,  and  shares  common  methodologies,
reporting  channels  and  governance  processes  that  apply  across  the  enterprise  risk  management  program,  in  areas  such  as  legal,  compliance,  strategic,
operational, and financial risk.

Our cybersecurity program includes:

•

•

•

•

•

•

risk  assessments  designed  to  help  identify  material  cybersecurity  risks  to  our  critical  systems,  information,  products,  services,  and  our  broader
enterprise IT environment;

a security team principally responsible for managing (1) our cybersecurity risk assessment processes, (2) our security controls, and (3) our response to
cybersecurity incidents;

the use of external service providers, where appropriate, to assess, test or otherwise assist with aspects of our security controls;

cybersecurity awareness training of our employees, incident response personnel, and senior management;

a cybersecurity incident response plan that includes procedures for responding to cybersecurity incidents; and

a third-party risk management process for service providers, suppliers, and vendors that have access to our critical systems and information.

We have not identified risks from known cybersecurity threats, including as a result of any prior cybersecurity incidents, that have materially affected or are
reasonably likely to materially affect us, including our operations, business strategy, results of operations, or financial condition. For more information, see
the section titled “Risk Factor— Our information technology systems, or those of our CROs or other contractors or consultants we may utilize, may fail,
suffer disruptions or suffer security breaches, which could result in a material disruption of our product development programs.”

Cybersecurity Governance

Our  board  considers  cybersecurity  risk  as  part  of  its  risk  oversight  function  and  has  delegated  to  the  Audit  and  Compliance  Committee  (Committee)
oversight  of  cybersecurity  and  other  information  technology  risks.  The  Committee  oversees  management’s  implementation  of  our  cybersecurity  risk
management program, maintains a strategic role in coordinating cyber risk initiatives and policies, and confirming their efficacy.

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The Committee receives regular reports from management on our cybersecurity posture. In addition, management updates the Committee, as necessary,
regarding any material cybersecurity incidents, as well as any incidents with lesser impact potential.

The Committee reports to the full Board regarding its activities, including those related to cybersecurity. The Board also receives periodic briefings from
management on our cybersecurity program. The Board members receive presentations on cybersecurity topics from our IT Senior Director, internal security
staff or external experts as part of the Board’s continuing education on topics that impact public companies.

Our  management  team,  including  our  Chief  Legal  Officer,  Chief  Financial  Officer  and  IT  Senior  Director,  has  over  a  combined  50  years  of  risk
management experience, including our IT Senior Director who has over 15 years of experience overseeing cybersecurity and risk management. This team
is responsible for assessing and managing our material risks from cybersecurity threats, and has primary responsibility for our overall cybersecurity risk
management program and supervises both our internal cybersecurity personnel and our retained external cybersecurity consultants. Our management team’s
experience includes experience running cybersecurity programs at similarly situated commercial biotechnology organizations and navigating the associated
risk landscape.

Our management team supervises efforts to prevent, detect, mitigate, and remediate cybersecurity risks and incidents through various means, which may
include  briefings  from  internal  security  personnel;  threat  intelligence  and  other  information  obtained  from  governmental,  public  or  private  sources,
including external consultants engaged by us; and alerts and reports produced by security tools deployed in the IT environment.

ITEM 2.    PROPERTIES

Our headquarters is currently located in Waltham, Massachusetts and consists of 17,111 square feet of leased office space under a lease agreement that
expires in June 2026. In addition, we lease 72,500 square feet of office and laboratory space in Fremont, California under a lease agreement that expires in
March 2025 and 4,768 square feet of office space in Milwaukee, Wisconsin under a lease agreement that expires in February 2026. Prior to October 2021,
our headquarters were co-located in Fremont, California and Waltham, Massachusetts.

ITEM 3.    LEGAL PROCEEDINGS

On  July  30  and  August  12,  2021,  two  putative  securities  class  action  lawsuits  were  commenced  in  the  U.S.  District  Court  for  the  Northern  District  of
California naming as defendants Ardelyx and two current officers captioned Strezsak v. Ardelyx, Inc., et al., Case No. 4:21-cv-05868-HSG, and Siegel v.
Ardelyx, Inc., et al.,  Case  No.  5:21-cv-06228-HSG  (together,  the  Securities  Class  Actions).  The  complaints  allege  that  the  defendants  violated  Sections
10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 thereunder, by making false and misleading statements and omissions
of material fact related to tenapanor. The plaintiffs seek damages and interest, and an award of costs, including attorneys’ fees. On July 19, 2022, the court
consolidated the two putative class actions and appointed a lead plaintiff and lead counsel. The lead plaintiff filed an amended complaint on September 29,
2022. Defendants filed a motion to dismiss the amended complaint on December 2, 2022. In January and February 2023, in lieu of filing a response to
defendant’s motion to dismiss, plaintiffs filed a motion seeking leave to further amend their complaint and defendants filed an opposition to the motion for
leave to further amend the complaint. On April 6, 2023, the court granted plaintiff’s motion for leave to further amend the complaint. With the second
amended complaint, the plaintiffs seek to represent all persons who purchased or otherwise acquired Ardelyx securities between March 6, 2020 and July
19, 2021. Defendants filed a motion to dismiss the amended complaint on June 2, 2023. On August 22, 2023, the court cancelled the hearing scheduled for
September 14, 2023 on the motion to dismiss the amended complaint and indicated its decisions to instead rule on the filed briefs. We believe the plaintiff’s
claims are without merit and we have not recorded any accrual for a contingent liability associated with these legal proceedings.

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On December 7, 2021 and March 29, 2022, two verified shareholders derivative lawsuits were filed in the U.S. District Court for the Northern District of
California purportedly on behalf of Ardelyx against certain of Ardelyx’s executive officers and members of our board of directors, captioned Go v. Raab, et
al., Case No. 4:21-cv-09455-HSG, and Morris v. Raab, et al., Case No. 4:22-cv-01988-JSC. The complaints allege that the defendants' violations of Section
14(a) of the Securities Exchange Act of 1934, as amended, breaches of fiduciary duties, unjust enrichment, abuse of control, gross mismanagement, and
waste  of  corporate  assets  for  personally  making  and/or  causing  Ardelyx  to  make  materially  false  and  misleading  statements  regarding  the  Company’s
business,  operations  and  prospects.  The  complaint  seeks  contribution  under  Sections  10(b)  and  21D  of  the  Securities  Exchange  Act  of  1934  from  two
executive  officers.  On  January  19,  and  April  27,  2022,  the  court  granted  the  parties’  stipulation  to  stay  the  Go  and  Morris  actions,  respectively,  until
resolution of the anticipated motion(s) to dismiss in the Securities Class Actions. On October 25, 2022, the parties filed a stipulation to consolidate and stay
the Go and Morris actions, and on October 27, 2022, the court consolidated the Go and Morris action and stayed the consolidated action pending resolution
of the anticipated motion(s) to dismiss in the Securities Class Action. We believe the plaintiff’s claims are without merit and we have not recorded any
accrual for a contingent liability associated with these legal proceedings.

From time to time, we may be involved in legal proceedings arising in the ordinary course of business. As of December 31, 2023, there is no litigation
pending  that  would  reasonably  be  expected  to  have  a  material  adverse  effect  on  our  results  of  operations  and  financial  condition,  and  no  contingent
liabilities were accrued as of December 31, 2023.

ITEM 4.    MINE SAFETY DISCLOSURES

Not applicable.

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ITEM 5.    MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF

PART II

EQUITY SECURITIES

Common Stock

On June 19, 2014, our common stock commenced trading on The Nasdaq Global Market under the symbol “ARDX”. Prior to that date, there was no public
trading market for our common stock. As of December 31, 2023, there were 25 holders of record of our common stock.

Dividends

We  have  never  declared  or  paid  cash  dividends  on  our  capital  stock.  We  currently  intend  to  retain  any  future  earnings  to  finance  the  growth  and
development of our business.

Securities Authorized for Issuance under Equity Compensation Plans

The information required by this item regarding executive compensation will be incorporated by reference to the information set forth in the sections titled
“Executive Compensation” in our Proxy Statement.

Recent Sales of Unregistered Securities

None.

Use of Proceeds

Not applicable.

Issuer Purchases of Equity Securities

Not applicable.

ITEM 6. [RESERVED]

ITEM 7.    MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

You should read the following discussion and analysis of our financial condition and results of operations in conjunction with our financial statements and
related  notes  included  elsewhere  in  this  report.  This  discussion  and  other  parts  of  this  report  contain  forward-looking  statements  that  involve  risk  and
uncertainties, such as statements of our plans, objectives, expectations and intentions. Our actual results could differ materially from those discussed in
these forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed in the section of
this report entitled “Risk Factors.” These forward-looking statements speak only as of the date hereof. Except as required by law, we assume no obligation
to update or revise these forward-looking statements for any reason. Unless the context requires otherwise, the terms “Ardelyx”, “Company”, “we”, “us”,
and “our” refer to Ardelyx, Inc.

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OVERVIEW

We  are  a  biopharmaceutical  company  founded  with  a  mission  to  discover,  develop  and  commercialize  innovative  first-in-class  medicines  that  meet
significant unmet medical needs. We developed a unique and innovative platform that enabled the discovery of new biological mechanisms and pathways
to develop potent, and efficacious therapies that minimize the side effects and drug-drug interactions frequently encountered with traditional, systemically
absorbed  medicines.  The  first  molecule  we  discovered  and  developed  was  tenapanor,  a  minimally  absorbed,  first-in-class,  oral,  small  molecule  therapy.
Tenapanor, branded as IBSRELA , is approved in the U.S. for the treatment of adults with irritable bowel syndrome with constipation (IBS-C). Tenapanor,
branded as XPHOZAH , was approved by the U.S. Food and Drug Administration (U.S. FDA) on October 17, 2023, to reduce serum phosphorus in adults
with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of
any  dose  of  phosphate  binder  therapy.  We  also  have  a  development  stage  asset,  RDX013  for  adult  patients  with  CKD  and/or  heart  failure  with
hyperkalemia, or elevated serum potassium, and a discovery phase asset, RDX020 for adult patients with metabolic acidosis, a serious electrolyte disorder,
in patients with CKD.

®

®

Since  commencing  operations  in  October  2007,  substantially  all  our  efforts  have  been  dedicated  to  our  research  and  development  (R&D)  activities,
including developing tenapanor and developing our proprietary drug discovery and design platform, as well as commercialization activities, including the
marketing and sales of IBSRELA and XPHOZAH. We realized our first product sales of IBSRELA in March 2022 and realized our first product sales of
XPHOZAH in November 2023. As of December 31, 2023, we had an accumulated deficit of $846.2 million.

We  expect  to  continue  to  incur  operating  losses  for  the  foreseeable  future  as  we  invest  in  the  commercialization  of  IBSRELA  and  XPHOZAH,  incur
manufacturing  and  development  cost  for  tenapanor,  and  incur  R&D  costs  related  to  potential  new  product  candidates.  To  date,  we  have  funded  our
operations from the sale and issuance of common stock and convertible preferred stock, funds from our collaboration partnerships, which includes license
fees, milestones and product supply revenue, funds from our loan agreement with SLR Investment Corp. (SLR), as amended on August 1, 2022, February
9, 2023 and October 17, 2023 (collectively, the 2022 Loan Agreement), as well as from sales of IBSRELA and XPHOZAH.

Our Commercial Products

IBSRELA for IBS-C

Our  unique  discovery  platform  and  deep  understanding  of  the  primary  mechanism  of  sodium  transport  in  the  intestine  resulted  in  our  discovery  and
development  of  IBSRELA,  a  first-in-class,  U.S.  FDA  approved,  sodium  hydrogen  exchange  3  (NHE3)  inhibitor  for  the  treatment  of  IBS-C  in  adults.
IBSRELA acts locally in the gut and is minimally absorbed. IBS-C is a gastrointestinal (GI) disorder characterized by both abdominal pain and altered
bowel habits. IBS-C is associated with significantly impaired quality of life, reduced productivity, and substantial economic burden.

We  recognized  our  first  sales  of  IBSRELA  in  the  U.S.  in  March  2022.  For  our  commercial  launch  of  IBSRELA,  we  designed  a  market-responsive
commercial strategy and built a commercial organization highly experienced in launching novel therapies into specialty areas. The dynamics of the IBS-C
market reflect an established patient base, limited number of competitors all confined to a single mechanism of action, concentrated number of prescribers,
and recognized unmet need. In addition, market research indicated a favorable response to the IBSRELA product profile as a novel mechanism therapy.
These dynamics enabled a targeted promotional focus on patients currently being managed for IBS-C by the approximately 9,000 high-writing healthcare
providers who account for approximately 50% of IBS-C prescriptions. Central to our go to market strategy for IBSRELA has been our highly experienced
specialty sales force, many with existing relationships across their GI target base, and omnichannel digital initiatives.

We  expect  competition  for  IBSRELA  will  come  largely  from  the  three  prescription  products  indicated  for  IBS-C:  Linzess  (linaclotide),  Amitiza
(lubiprostone)  and  Trulance  (plecanatide).  Generic  lubiprostone  is  also  available  in  the  U.S.  Additionally,  over-the-counter  products  and  prescription
therapies, not indicated for IBS-C are commonly used to treat the constipation component of IBS-C, alone and in combination with the IBS-C-indicated
prescription therapies.

We have established commercial agreements with Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. (Fosun Pharma) in China and Knight
Therapeutics, Inc. (Knight) in Canada for IBSRELA for IBS-C. Knight is currently marketing IBSRELA in Canada. In October 2023, we announced that
Fosun Pharma received approval from the Hong Kong Department of Health for the marketing application for tenapanor for the treatment of irritable bowel
syndrome with constipation (IBS-C).

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XPHOZAH  to  Reduce  Serum  Phosphorus  in  Adults  with  CKD  on  dialysis  as  Add-on  Therapy  in  Patients  who  have  an  Inadequate  Response  to
Phosphate Binders or who are Intolerant of any Dose of Phosphate Binder Therapy

On October 17, 2023, XPHOZAH, a first-in-class phosphate absorption inhibitor, received approval from the U.S. FDA to market XPHOZAH in the U.S.
to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an inadequate response to
phosphate binders or who are intolerant of any dose of phosphate binder therapy. XPHOZAH has a differentiated mechanism of action and acts locally in
the gut to inhibit NHE3. This results in the tightening of the epithelial cell junctions, thereby significantly reducing paracellular uptake of phosphate, the
primary  pathway  of  phosphate  absorption.  It  is  estimated  that  there  are  more  than  550,000  adult  patients  with  CKD  on  dialysis  in  the  U.S.  and
approximately eighty percent of those patients are being treated with phosphate lowering therapies. On average during 2020 through 2023, approximately
seventy  percent  of  patients  treated  with  phosphate  binders  to  treat  hyperphosphatemia  were  unable  to  consistently  maintain  phosphorous  levels  <=5.5
mg/dL over a six-month period. XPHOZAH is the first therapy for phosphate management that blocks phosphate absorption at the primary site of uptake.

We recognized our first sales of XPHOZAH in the U.S. in November 2023. For our commercial launch of XPHOZAH, we designed a market-responsive
commercial  strategy  and  built  a  commercial  organization  highly  experienced  and  knowledgeable  of  the  nephrology  market.  The  dynamics  of  the
hyperphosphatemia market reflect an established patient base, limited number of competitors all confined to a single mechanism of action, concentrated
number of prescribers, and recognized unmet need. In addition, market research indicated a high level of awareness, interest and intent to adopt XPHOZAH
upon approval and favorable response to the XPHOZAH product profile as a novel mechanism therapy. These dynamics enabled a targeted promotional
focus on patients currently being managed for hyperphosphatemia by the approximately 8,000 nephrology healthcare providers who write approximately
80% of phosphate lowering therapy prescriptions. Central to our go to market strategy for XPHOZAH is our highly experienced specialty sales force, many
with existing relationships across their nephrology target base, and innovative omnichannel digital initiatives.

XPHOZAH is indicated to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in patients who have an
inadequate  response  to  phosphate  binders  or  who  are  intolerant  of  any  dose  of  phosphate  binder  therapy.  The  various  types  of  phosphate  binders
commercialized  in  the  U.S.  include  the  following:  Calcium  acetate  (several  prescription  brands  including  PhosLo  and  Phoslyra);  Lanthanum  carbonate
(Fosrenol); Sevelamer hydrochloride (Renagel); Sevelamer carbonate (Renvela); Sucroferric oxyhydroxide (Velphoro); and Ferric citrate (Auryxia). All of
the  listed  phosphate  binders  are  available  as  generics  in  the  U.S.,  with  the  exception  of  Velphoro  and  Auryxia.  Additionally,  over-the-counter  calcium
carbonate, such as Tums and Caltrate, is also used to bind phosphorus.

In addition to the currently available phosphate binders, we are aware of at least four other binders in development, including fermagate (Alpharen), an
iron-based binder in Phase 3 being developed by Opko Health, Inc., PT20, an iron-based binder in Phase 3 being developed by Shield Therapeutics, AP-
301  in  Phase  2  being  developed  by  Alebund  Pharmaceutical  (Hong  Kong)  Limited,  and  Oxylanthanum  Carbonate  (OLC),  which  has  demonstrated
pharmacodynamic  bioequivalence  to  Fosrenol.  OLC  is  being  developed  by  Unicycive  Therapeutics,  which  has  announced  its  plans  to  seek  U.S.  FDA
approval via the 505(b)(2) pathway. Additionally, Chugai and Alebund are developing EOS789, an inhibitor of phosphate transporters NaPi-2b, PiT-1, and
PiT-2, thus far studied in a phase 1 clinical trial.

In November 2023, XPHOZAH was granted orphan drug designation by the U.S. FDA for the treatment of pediatric hyperphosphatemia.

We  have  established  commercial  agreements  with  Kyowa  Kirin,  Co.  Ltd.  (Kyowa  Kirin)  in  Japan,  Fosun  Pharma  in  China  and  Knight  in  Canada  for
tenapanor for hyperphosphatemia. In July 2023, we announced that a New Drug Application (NDA) for tenapanor had been accepted for review by China’s
Center for Drug Evaluation of the National Medical Products Administration (NMPA) for the control of serum phosphorus in adult patients with CKD on
hemodialysis. In September 2023, we announced that Kyowa Kirin received approval from the Japanese Ministry of Health, Labour and Welfare (MHLW)
for the NDA for tenapanor for the improvement of hyperphosphatemia in adult patients with CKD on dialysis.

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Discovery and Developmental Assets

We  have  a  small  molecule  potassium  secretagogue  program,  RDX013,  for  the  potential  treatment  of  hyperkalemia,  or  elevated  serum  potassium.
Hyperkalemia is a common problem in patients with heart and kidney disease, particularly in patients taking customary blood pressure medications known
as renin-angiotensin-aldosterone system (RAAS) inhibitors. RDX013 is a novel mechanism agent designed to target the underlying biological mechanisms
of potassium secretion to lower elevated potassium. We have completed a Phase 2 dose ranging clinical trial evaluating the safety and efficacy of RDX013
for the treatment of hyperkalemia in CKD patients who are not on dialysis. While the results of the study demonstrated an acceptable safety and tolerability
profile  for  RDX013  and  supported  proof  of  concept  in  its  ability  to  lower  serum  potassium  levels,  with  statistically  significant  reductions  compared  to
placebo after eight days of treatment, the study did not meet its primary endpoint of significantly reducing serum potassium levels compared to placebo
after four weeks of treatment.

We  have  a  discovery  program  targeting  the  inhibition  of  the  chloride  bicarbonate  exchanger  for  the  treatment  of  metabolic  acidosis,  a  highly  prevalent
comorbidity in CKD patients that is strongly correlated with disease progression and adverse outcomes. We have identified lead compounds that are potent,
selective and proprietary inhibitors of bicarbonate secretion.

We do not currently expect to meaningfully advance either of these two assets until such time as we have determined our available resources can support
additional activities after prioritization of the commercialization of IBSRELA and XPHOZAH.

Collaboration Partners

We have exclusive rights to tenapanor in the U.S. and we have established agreements with Kyowa Kirin in Japan, Fosun Pharma in China and Knight in
Canada for the development and commercialization of tenapanor for certain indications in their respective territories.

In March 2018, we entered into an exclusive license agreement with Knight (Knight Agreement) for the development, commercialization and distribution
of  tenapanor  in  Canada  for  hyperphosphatemia  and  IBS-C.  In  March  2021,  Knight  announced  the  commercial  availability  of  IBSRELA  in  Canada,
following its approval by Health Canada in April 2020. Under the terms of the Knight Agreement, Knight paid us a $2.3 million non-refundable, one-time
payment  in  March  2018.  We  may  also  be  eligible  to  receive  approximately  CAD  22.2  million  for  development  and  commercialization  milestones,  or
approximately $16.7 million at the currency exchange rate on December 31, 2023, of which $0.7 million has been received and recognized as revenue as of
December 31, 2023. We are also eligible to receive royalties throughout the term of the agreement, and a transfer price for manufacturing services.

In  November  2017,  we  entered  into  an  exclusive  license  agreement  with  Kyowa  Kirin  (2017  Kyowa  Kirin  Agreement)  for  the  development,
commercialization and distribution of tenapanor in Japan for cardiorenal indications. Under the terms of the 2017 Kyowa Kirin Agreement, we received a
$30.0 million upfront payment from Kyowa Kirin, and we may be entitled to receive up to $55.0 million in total development and regulatory milestones, of
which $35.0 million has been recognized as revenue and received as of December 31, 2023. We may also be eligible to receive approximately ¥8.5 billion
for commercialization milestones, or approximately $60.3 million at the currency exchange rate on December 31, 2023, as well as reimbursement of costs
plus a reasonable overhead for the supply of product and royalties on net sales throughout the term of the agreement. As discussed in Note 8. Deferred
Royalty Obligation Related to the Sale of Future Royalties, the future royalties and commercial milestone payments we may receive under the 2017 Kyowa
Kirin Agreement will be remitted to HealthCare Royalty Partners IV, L.P. pursuant to a Royalty and Sales Milestone Interest Acquisition Agreement.

On  April  11,  2022,  we  entered  into  a  second  amendment  to  the  2017  Kyowa  Kirin  Agreement  (2022  Amendment).  Under  the  terms  of  the  2022
Amendment, we and Kyowa Kirin agreed to a reduction in the royalty rate payable to us by Kyowa Kirin upon net sales of tenapanor in Japan. The royalty
rate was reduced from the high teens to low double digits for a two-year period of time following the first commercial sale in Japan, and then to mid-single
digits  for  the  remainder  of  the  royalty  term.  As  discussed  in  Note  8.  Deferred  Royalty  Obligation  Related  to  the  Sale  of  Future  Royalties,  the  future
royalties we may receive under the 2017 Kyowa Kirin Agreement will be remitted to HealthCare Royalty Partners IV, L.P. pursuant to a Royalty and Sales
Milestone  Interest  Acquisition  Agreement.  As  consideration  for  the  reduction  in  the  royalty  rate,  Kyowa  Kirin  agreed  to  pay  us  up  to  an  additional
$40.0 million which has been received and recognized as revenue as of September 2023 as described below.

In October 2022, we announced that Kyowa Kirin submitted an NDA to the Japanese MHLW for tenapanor for the improvement of hyperphosphatemia in
adult patients with CKD on dialysis, which resulted in payment to us from Kyowa Kirin for an aggregate of $35.0 million for milestone payments and
payments under the 2022 Amendment.

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In  September  2023,  we  announced  that  Kyowa  Kirin  received  approval  from  the  Japanese  MHLW  for  the  NDA  for  tenapanor  for  the  improvement  of
hyperphosphatemia in adult patients with chronic kidney disease on dialysis, which resulted in payment to us from Kyowa Kirin for an aggregate of $30.0
million for milestone payments and payments under the 2022 Amendment.

In December 2017, we entered into an exclusive license agreement with Fosun Pharma (Fosun Agreement) for the development and commercialization of
tenapanor in China for both hyperphosphatemia and IBS-C. Under the terms of the Fosun Agreement, Fosun paid us a $12.0 million upfront license fee. In
July 2023, we announced that an NDA for tenapanor had been accepted for review by China’s Center for Drug Evaluation of the NMPA for the control of
serum phosphorus in adult patients with chronic kidney disease on hemodialysis. This acceptance triggered a $2.0 million milestone payment to us under
the terms of the Fosun Agreement, which we received in the third quarter of 2023.

In October 2023, we announced that the U.S. FDA has approved XPHOZAH to reduce serum phosphorus in adults with CKD on dialysis as add-on therapy
in  patients  who  have  an  inadequate  response  to  phosphate  binders  or  who  are  intolerant  of  any  dose  of  phosphate  binder  therapy.  This  triggered  an
additional $3.0 million milestone payment to us under the terms of the Fosun Agreement, which was received during the first quarter of 2024. Also, in
October 2023, we announced that Fosun Pharma received approval from the Hong Kong Department of Health for the marketing application for tenapanor
for the treatment of irritable bowel syndrome with constipation (IBS-C). We may be entitled to receive development and commercialization milestones of
up to $113.0 million, of which $8.0 million has been recognized as revenue and $5.0 million has been received as of December 31, 2023 and $3.0 million
was  received  in  January  2024,  as  well  as  reimbursement  of  cost  plus  a  reasonable  overhead  for  the  supply  of  product  and  tiered  royalties  on  net  sales
ranging from the mid-teens to 20%.

FINANCIAL OPERATIONS OVERVIEW

Revenue

Our  revenue  to  date  has  been  generated  primarily  through  a  combination  of  product  sales  and  payments  in  connection  with  license,  research  and
development collaborative agreements with our various collaboration partners. We realized our first commercial product sales of IBSRELA beginning in
March 2022 and our first commercial product sales of XPHOZAH in November 2023. In the future, we may generate revenue from a combination of our
own  product  sales  and  payments  in  connection  with  our  current  or  future  collaborative  partnerships,  including  license  fees,  other  upfront  payments,
milestone  payments,  royalties  and  payments  for  drug  product  and/or  drug  substance.  We  expect  that  any  revenue  we  generate  will  fluctuate  in  future
periods as a result of, among other factors: the extent to which we are successful in our commercialization of IBSRELA and XPHOZAH; our ability to
obtain and sustain an adequate level of coverage and reimbursement for IBSRELA and XPHOZAH by third-party payors; whether and the extent to which
we are successful in our commercialization of XPHOZAH; whether or when XPHOZAH, along with other oral ESRD-related drugs without an injectable
or  intravenous  equivalent,  are  bundled  into  the  end  stage  renal  disease  prospective  payment  system  (ESRD  PPS),  and  the  manner  in  which  such
introduction into the ESRD PPS may occur, including the length of any applicable Transitional Drug Add-on Payment Adjustment (TDAPA) period, the
amount of the add-on payment available during the TDAPA period and whether, and the extent to which, the ESRD PPS base rate is adjusted following any
applicable  TDAPA  period;  the  timing  and  progress  of  goods  and  services  provided  pursuant  to  our  current  or  future  collaborative  partnerships;  our
collaborators’ achievement of clinical, regulatory or commercialization milestones, to the extent achieved; the timing and amount of any payments to us
relating to the aforementioned milestones; addressing any competing technological and market developments; maintaining, protecting and expanding our
portfolio  of  intellectual  property  rights,  including  patents,  trade  secrets,  and  know-how,  and  our  ability  to  develop,  manufacture  and  commercialize  our
product candidates and products without infringing intellectual property rights of others; attracting, hiring, and retaining qualified personnel; and the extent
to  which  tenapanor  or  other  licensed  products  are  approved  and  successfully  commercialized  by  a  collaboration  partner.  If  our  current  collaboration
partners  or  any  future  collaboration  partners  fail  to  obtain  regulatory  approval  for  tenapanor  or  other  licensed  products,  our  ability  to  generate  future
revenue from our collaborative arrangements, and our results of operations and financial position, would be materially and adversely affected. Our past
revenue performance is not necessarily indicative of results to be expected in future periods.

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Cost of Goods Sold

Cost of product sales consists of the cost of commercial goods sold to our Customers. Other cost of revenue consists of the cost of materials sold to our
international  partners  under  product  supply  agreements,  as  well  as  payments  due  to  AstraZeneca  AB  (AstraZeneca)  based  on  sales  of  tenapanor.  We
capitalize  inventory  costs  associated  with  the  production  of  our  products  after  regulatory  approval  or  when,  based  on  management’s  judgment,  future
commercialization is considered probable and the future economic benefit is expected to be realized. Otherwise, such costs are expensed as research and
development. A portion of the costs of IBSRELA and XPHOZAH units recognized as revenue during the years ended December 31, 2023 and 2022 were
expensed in periods prior to the commencement of capitalization of inventory costs for each respective product. We believe our cost of goods sold for the
years ended December 31, 2023 and 2022 would have been $4.4 million and $1.9 million higher, respectively, if we had not previously expensed certain
material and production costs with respect to the units sold. As of December 31, 2023 and December 31, 2022, we had approximately $21.8 million and
$28.0 million, respectively, of inventory on hand that was previously expensed as research and development expense and will not be reported as cost of
goods sold in future periods when sales of IBSRELA and XPHOZAH are recognized as revenue.

Other  cost  of  revenue  includes  payments  due  to  AstraZeneca,  which  under  the  terms  of  a  termination  agreement  entered  into  in  2015  (AstraZeneca
Termination Agreement) is entitled to (i) future royalties at a rate of 10% of net sales of tenapanor or other NHE3 products by us or our licensees, and (ii)
20%  of  non-royalty  revenue  received  from  our  collaboration  partners  in  connection  with  the  development  and  commercialization  of  tenapanor  or  other
NHE3 products. We have agreed to pay AstraZeneca up to a maximum of $75.0 million in the aggregate for (i) and (ii). We recognize these expenses as
other  cost  of  revenue  when  we  recognize  the  corresponding  revenue  that  gives  rise  to  payments  due  to  AstraZeneca.  To  date,  we  have  recognized  an
aggregate  of  $27.6  million  as  other  cost  of  revenue  under  the  AstraZeneca  Termination  Agreement.  See  details  in  Note  7,  Collaboration  and  Licensing
Agreements, under AstraZeneca, in the notes to our financial statements, included in Part II, Item 8, of this Annual Report on Form 10-K.

Research and Development

We recognize all R&D expenses as they are incurred to support the discovery, research, development and manufacturing of our product candidates. R&D
expenses include, but are not limited to, the following:

•

•

•

•

•

•

•

external research and development expenses incurred under agreements with consultants, third-party contract research organizations (CROs) and
investigative  sites  where  a  substantial  portion  of  our  clinical  studies  are  conducted,  and  with  contract  manufacturing  organizations  where  our
clinical supplies are produced;

expenses associated with supplies and materials consumed in connection with our research operations;

expenses associated with producing XPHOZAH prior to U.S. FDA approval;

expenses associated with producing discovery and developmental assets prior to U.S. FDA approval;

other costs associated with research, clinical development and regulatory activities;

employee-related expenses, which include salaries, bonuses, benefits, travel and stock-based compensation; and

facilities  and  other  allocated  expenses,  which  include  direct  and  allocated  expenses  for  rent  and  maintenance  of  facilities,  depreciation  and
amortization expense, information technology expense and other supplies.

Selling, General and Administrative

Selling, general and administrative expenses relate to sales and marketing, finance, human resources, legal and other administrative activities, including
information  technology  investments.  Selling,  general  and  administrative  expenses  consist  primarily  of  personnel  costs,  outside  professional  services,
marketing, advertising and legal expenses, facilities costs not otherwise allocated to research and development and other general and administrative costs.

Interest Expense

Interest expense represents the interest associated with on our 2022 Loan Agreement.

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Non-cash interest expense related to the sale of future royalties

Non-cash interest expense related to the sale of future royalties represents the imputed interest expense on our deferred royalty obligation related to the sale
of future royalties using the effective interest method. As further described in Note 8. Deferred Royalty Obligation Related to the Sale of Future Royalties,
in  June  2022,  we  and  HealthCare  Royalty  Partners  IV,  L.P.  (HCR)  entered  into  a  Royalty  and  Sales  Milestone  Interest  Acquisition  Agreement  (HCR
Agreement). Under the terms of the HCR Agreement, HCR agreed to pay us up to $20.0 million in exchange for the royalty payments and commercial
milestone payments (collectively the Royalty Interest Payments) that we may receive under our 2017 License Agreement with Kyowa Kirin based upon
Kyowa Kirin's net sales of tenapanor in Japan for hyperphosphatemia. As part of the HCR Agreement, we have received a $10.0 million upfront payment
and a $5.0 million milestone payment from HCR, which we recorded as a deferred royalty obligation on our balance sheet. Non-cash interest expense will
be recognized over the life of the HCR Agreement using the effective interest method based on the imputed interest rate derived from estimated amounts
and timing of future royalty payments to be received from Kyowa Kirin.

Other Income, net

Other income, net consists of interest income earned on our cash, cash equivalents and available-for-sale investments, the periodic revaluation of the exit
fee related to our 2022 Loan Agreement, gains on sales of property and equipment, and currency exchange gains and losses.

Provision for Income Taxes

Our provision for income taxes includes current and deferred tax, including foreign withholding taxes paid on payments received from certain collaboration
partners. Deferred income taxes reflect the tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting
purposes and the amounts used for income tax purposes. Our deferred tax assets continue to be fully offset by a valuation allowance, including deferred tax
assets related to our net operating loss carryforwards, which may be subject to annual limitations as a result of ownership changes that may have occurred
or could occur in the future.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

A  detailed  discussion  of  our  significant  accounting  policies  can  be  found  in  Note  2,  Summary  of  Significant  Accounting  Policies,  in  the  notes  to  our
financial  statements,  included  in  Part  II,  Item  8,  of  this  Annual  Report  on  Form  10-K.  Critical  accounting  policies  are  those  that  require  significant
judgment and/or estimates by management at the time that financial statements are prepared such that materially different results might have been reported
if other assumptions had been made. These estimates form the basis for making judgments about the carrying values of assets and liabilities. We base our
estimates and judgments on experience and on various other assumptions that we believe to be reasonable under the circumstances. Actual results could
differ materially from these estimates.

We  consider  certain  accounting  policies  related  to  revenue  recognition,  inventory,  accrued  research  and  development  expenses  to  be  critical  policies  to
understanding the judgments and estimates applied in our reported financial results.

Product Sales, Net

We account for our commercial product sales, net in accordance with Topic 606 – Revenue from Contracts with Customers. We received approval from the
FDA  to  market  IBSRELA  in  the  U.S.  in  September  2019  and  to  market  XPHOZAH  in  the  U.S.  in  October  2023.  We  began  selling  IBSRELA  and
XPHOZAH  in  the  U.S.  in  March  2022  and  November  2023,  respectively.  We  distribute  IBSRELA  principally  through  major  wholesalers,  specialty
pharmacies and group purchasing organizations (GPOs) (collectively, our IBSRELA Customers). XPHOZAH is principally distributed through a specialty
wholesaler  (XPHOZAH  Customer)  to  select  specialty  pharmacies  (collectively,  IBSRELA  Customers  and  XPHOZAH  Customers,  “Customers”).  Our
Customers subsequently sell IBSRELA and XPHOZAH to pharmacies and patients. Separately, we enter into arrangements with third parties that provide
for government-mandated rebates, chargebacks and discounts. Revenue from product sales is recognized when our performance obligations are satisfied,
which is when Customers obtain control of our product and occurs upon delivery.

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Reserves for Variable Consideration

Revenues from product sales are recorded at the net sales price (transaction price), which includes estimates of variable consideration which may be settled
in the form of off-invoice discounts, chargebacks, or rebates. Variable consideration includes discounts to customers and government programs, wholesaler
fees, group purchasing organization administrative fees, patient copay assistance, and estimated product returns. These estimates are based on the amounts
earned or to be claimed for related sales and are classified as reductions of gross accounts receivable if settlement is expected to occur through a reduction
in  the  amounts  paid  by  our  Customers  or  a  current  liability  if  settlement  is  expected  to  occur  through  a  payment  from  us.  Where  appropriate,  these
estimates are based on factors such as industry data and forecasted customer buying and payment patterns, our experience, current contractual and statutory
requirements, specific known market events and trends. These reductions to gross sales reflect our best estimates of the amount of consideration to which
we are entitled based on the terms of the contract. Variable consideration is included in the transaction price only to the extent that it is probable that a
significant  reversal  in  the  amount  of  cumulative  revenue  recognized  will  not  occur  when  the  uncertainty  associated  with  the  variable  consideration  is
subsequently  resolved.  Actual  amounts  of  consideration  ultimately  received  may  differ  from  our  estimates.  If  actual  results  in  the  future  vary  from  our
estimates,  we  adjust  these  estimates,  which  would  affect  product  revenue  and  earnings  in  the  period  such  variances  become  known.  As  we  gain  more
experience, estimates will be more heavily based on the expected utilization from historical data we have accumulated since the IBSRELA and XPHOZAH
product launches. Changes in estimates recorded through December 31, 2023 have not been material.

Rebates: Rebates include wholesaler fees, GPO fees, as well as mandated discounts under the Medicaid Drug Rebate Program (Medicaid) and the Medicare
Coverage Gap Program (Medicare). Estimates for rebates are recorded in the same period the related gross revenue is recognized, resulting in a reduction
of product revenue. We estimate our Medicaid and Medicare rebates based upon the estimated payor mix, and statutory discount rates. Our estimates for
payor  mix  are  guided  by  payor  information  received  from  specialty  pharmacies,  expected  utilization  for  wholesaler  sales  to  pharmacies,  and  available
industry payor information and therefore require the most estimation and judgment of our gross to net deductions.

Chargebacks: Chargebacks are discounts that occur when certain contracted purchasers purchase directly from our wholesalers at a discounted price. The
wholesaler, in turn, charges back the difference between the price initially paid to us by the wholesaler and the discounted price paid to the wholesaler by
the contracted purchaser. Amounts for estimated chargebacks are established in the same period that the related gross revenue is recognized, resulting in a
reduction of product revenue and accounts receivable. The accrual for wholesaler chargebacks is estimated based on known chargeback rates, known sales
to wholesalers, and known sales from wholesalers to their chargeback-eligible customers.

Discounts  and  Fees:  Our  payment  terms  are  generally  30  to  60  days.  Wholesalers,  GPOs  and  specialty  pharmacies  are  offered  various  forms  of
consideration, including off-invoice discounts which may be paid to GPOs and specialty pharmacies. Wholesalers and GPOs may also receive prompt pay
discounts for payment within a specified period. We expect discounts to be earned when offered and therefore, we deduct the full amount of these discounts
from product sales when revenue is recognized, resulting in a reduction of product revenue and accounts receivable.

Other Reserves: Patients who have commercial insurance may receive copay assistance when product is dispensed by pharmacies to patients. We estimate
the amount of copay assistance provided to eligible patients based on the terms of the program, and redemption information provided by third-party claims
processing organizations. We also estimate the amount of copay assistance that will be provided to patients associated with product which we have sold but
which  has  not  yet  been  dispensed  to  commercial  patients,  which  requires  significant  estimation  and  judgment.  Our  estimates  are  recorded  in  accounts
payable and accrued expenses and other current liabilities on the balance sheets. Other reserves include estimated product returns which are recorded in the
same period the related gross revenue is recognized, resulting in a reduction of product revenue as well as accounts receivable. We estimate our product
returns reserve based upon our experience and specific known market events and trends. As we have experienced limited product returns, establishing the
appropriate level of product returns reserve require estimation and judgment.

Collaboration Revenue Recognition

We generate collaboration revenue primarily from research and collaboration and license agreements with customers. Goods and services in the agreements
may  include  the  grant  of  licenses  for  the  use  of  our  technology,  the  provision  of  services  associated  with  the  research  and  development  of  product
candidates, manufacturing services, and participation in joint steering committees. The terms of these arrangements typically include payment to us of one
or more of the following: non-refundable, up-front license fees; research, development, regulatory and commercial milestone payments; reimbursement of
research and development services; option payments; reimbursement of certain costs; payments for manufacturing supply services; and future royalties on
net sales of licensed products.

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As part of the accounting for contracts with customers, we develop assumptions that require judgment to determine whether promised goods and services
represent  distinct  performance  obligations  and  the  standalone  selling  price  for  each  performance  obligation  identified  in  the  contract.  Determining  the
standalone  selling  price  for  performance  obligations  requires  significant  judgment,  and  when  an  observable  price  of  a  promised  good  or  service  is  not
readily  available,  we  consider  relevant  assumptions  to  estimate  the  standalone  selling  price,  including,  as  applicable,  market  conditions,  development
timelines, probabilities of technical and regulatory success, reimbursement rates for personnel costs, forecasted revenues, potential limitations to the selling
price of the product and discount rates. We also use judgment to evaluate whether the milestones are considered probable of being reached and estimate the
amount to be included in the transaction price using the most likely amount method. At the end of each subsequent reporting period, we re-evaluate the
probability  of  achievement  of  such  development  milestones  and  any  related  constraints,  and  if  necessary,  adjust  our  estimate  of  the  overall  transaction
price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect earnings in the period of adjustment.

Inventory

We capitalize inventory costs associated with the production of our products after regulatory approval or when, based on management’s judgment, future
commercialization is considered probable and the future economic benefit is expected to be realized. Otherwise, such costs are expensed as research and
development. Prior to the regulatory approval of drug product candidates, we incurred expenses for the manufacture of drug product that could potentially
be available to support the commercial launch of our products or could be sold to our international partners under product supply agreements. We began to
capitalize inventory costs associated with IBSRELA during the fourth quarter of 2021, when our intent to commercialize IBSRELA was established and we
commenced preparation for the commercial launch of IBSRELA, which was when it was determined that the inventory had a probable future economic
benefit.  We  began  to  capitalize  inventory  costs  associated  with  XPHOZAH  during  the  fourth  quarter  of  2023,  following  approval  by  the  U.S.  FDA  to
market XPHOZAH in the U.S., which was when it was determined that the inventory had a probable future economic benefit.

Inventory  is  stated  at  the  lower  of  cost  or  estimated  net  realizable  value  with  cost  determined  under  the  specific  identification  method.  Inventory  costs
include  the  cost  of  materials,  third-party  contract  manufacturing,  third-party  packaging  services,  freight,  labor  costs  for  personnel  involved  in  the
manufacturing process, and indirect overhead costs. We primarily use actual costs to determine the cost basis for inventory, and therefore there is limited
estimation or judgment involved. The determination of whether inventory costs will be realizable requires management review of the expiration dates of
IBSRELA and XPHOZAH compared to our forecasted sales. If actual market conditions are less favorable than projected by management, write-downs of
inventory may be required, which would be recorded as cost of revenue in the statement of operations and comprehensive loss. As of December 31, 2023,
we have not recorded any write-downs for excess and obsolete inventory.

Accrued Expenses

As  part  of  the  process  of  preparing  our  financial  statements,  we  are  required  to  estimate  our  accrued  expenses.  This  process  involves  reviewing  open
contracts and purchase orders, communicating with our personnel to identify services that have been performed on our behalf and estimating the level of
service performed and the associated cost incurred for the service when we have not yet been invoiced or otherwise notified of the actual cost. The majority
of our service providers invoice us monthly in arrears for services performed or when contractual milestones are met. We make estimates of our accrued
expenses as of each balance sheet date in our financial statements based on facts and circumstances known to us at that time. We periodically confirm the
accuracy of our estimates with our service providers and make adjustments if necessary.

In  accruing  service  fees,  we  estimate  the  time  period  over  which  each  component  of  a  service  will  be  performed,  and  estimate,  with  vendor  input  if
appropriate. If the actual timing of the performance of services or the level of effort varies from our estimate, we adjust the accrued or prepaid expense
balance accordingly. Although we do not expect our estimates to be materially different from amounts actually incurred, if our estimates of the status and
timing of services performed differ from the actual status and timing of services performed, we may report amounts that are too high or too low in any
particular period.

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RESULTS OF OPERATIONS

Comparison of the Years Ended December 31, 2023, 2022 and 2021

Revenue

Below is a summary of our total revenue (dollars in thousands):

Product sales, net
Licensing revenue
Collaborative development revenue
Product supply revenue

Total revenues
(a) Percent change is not meaningful.

Year Ended December 31,

2023

2022

2021

$

$

82,526  $
35,809 
— 
6,121 
124,456  $

15,600  $
35,031 
— 
1,527 
52,158  $

—  $

5,013 
4,177 
907 
10,097  $

Change 
2023 vs. 2022

Change 
2022 vs. 2021

$

66,926 
778 
— 
4,594 
72,298 

%

429 % $
2 %
(a)
301 %
139 % $

$

15,600 
30,018 
(4,177)
620 
42,061 

%

(a)
599 %
(100)%
68 %

417 %

Below is a summary of our net product sales by product (dollars in thousands):

Product sales, net:

IBSRELA
XPHOZAH

Total product sales, net

Fiscal 2023 compared to 2022:

Year Ended December 31,

2023

2022

2021

$

$

80,062  $
2,464 
82,526  $

15,600  $
— 
15,600  $

— 
— 
— 

The increase in product sales, net during the year ended December 31, 2023 as compared to the same period in 2022 is primarily attributable to increased
net  product  sales  for  IBSRELA  and  is  primarily  volume  based  as  2023  was  a  full  year  of  sales  while  IBSRELA  sales  commenced  in  March  of  2022.
IBSRELA sales volumes increased in 2023 as awareness and prescriber experience with the product continued to grow following its commercial launch in
March 2022. Commercial sales of XPHOZAH commenced in November 2023.

Licensing revenue during the year ended December 31, 2023 was comparable to the same period in 2022. During the year ended December 31, 2023, we
earned an aggregate of $30.0 million for milestones under the 2017 Kyowa Kirin Agreement and payments under the 2022 Kyowa Kirin Amendment upon
approval from the Japanese MHLW for the NDA for tenapanor for the improvement of hyperphosphatemia in adult patients with CKD on dialysis. We also
earned an aggregate of $5.0 million in milestones under the terms of the Fosun Agreement upon acceptance of the NDA for tenapanor by China’s Center
for  Drug  Evaluation  of  the  NMPA  for  the  control  of  serum  phosphorus  in  adult  patients  with  CKD  on  hemodialysis  and  the  U.S.  FDA  approval  of
XPHOZAH  to  reduce  serum  phosphorus  in  adults  with  CKD  on  dialysis  as  add-on  therapy  in  patients  who  have  an  inadequate  response  to  phosphate
binders or who are intolerant of any dose of phosphate binder therapy.

The increase in product supply revenue during the year ended December 31, 2023 as compared to the same periods in 2022 is attributable to increased
product supply revenue to Kyowa Kirin.

Fiscal 2022 compared to 2021:

The increase in product sales, net during the year ended December 31, 2022 as compared to the same period in 2021 is attributable to net product

sales for IBSRELA that commenced in March 2022.

The increase in licensing revenue during the year ended December 31, 2022 as compared to the same period in 2021 is attributable to an aggregate of $35.0
million in milestone payments and payments under the second amendment to the 2017 KKC Agreement which we earned upon Kyowa Kirin's submission
of a New Drug Application to the Japanese MLHW for tenapanor for the improvement of hyperphosphatemia in adult patients with CKD on dialysis.

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The decrease in collaborative development revenue during the year ended December 31, 2022 as compared to the same period in 2021 is attributable to the
full recognition of collaborative development revenue for upfront payments associated with the 2019 Kyowa Kirin Agreement through the end of 2021.

The  increase  in  product  supply  revenue  during  the  year  ended  December  31,  2022  as  compared  to  the  same  period  in  2021  is  attributable  to  increased
product supply revenue in connection with the 2017 Kyowa Kirin Agreement.

Cost of Goods Sold

Below is a summary of our cost of goods sold (dollars in thousands):

Year Ended December 31,

2023

2022

2021

2,323 
15,472 
17,795  $

$

566 
3,551 
4,117  $

— 
1,000 
1,000  $

Change 
2023 vs. 2022

Change 
2022 vs. 2021

$
1,757 
11,921 
13,678 

%

310 %
336 %
332 % $

$

566 
2,551 
3,117 

%

(a)
255 %

312 %

Cost of product sales
Other cost of revenue

Total cost of goods sold
(a) Percent change is not meaningful.

Fiscal 2023 compared to 2022:

The increase to cost of product sales for the year ended December 31, 2023 as compared to the same period in 2022 is primarily attributable to cost of
goods sold for increased net product sales of IBSRELA.

The increase to other cost of revenue for the year ended December 31, 2023 as compared to the same period in 2022 is primarily attributable to payments
due  to  AstraZeneca  under  the  AstraZeneca  Termination  Agreement,  which  include  a  percentage  of  milestones  earned,  as  well  as  cost  of  goods  sold  for
increased product supply sold to our international partners.

Fiscal 2022 compared to 2021:

The increase to cost of product sales for the year ended December 31, 2022 as compared to the same period in 2021 was primarily attributable to $0.5
million for the cost of goods sold for product sales of IBSRELA during year ended December 31, 2022.

The increase in other cost of revenue for the year ended December 31, 2022 as compared to the same period in 2021 was primarily attributable to payments
due to AstraZeneca under the AstraZeneca Termination Agreement for IBSRELA product sales, net and for the milestone payment we received under the
second amendment to the 2017 Kyowa Kirin Agreement, which we earned upon Kyowa Kirin's submission of a NDA to the Japanese MHLW for tenapanor
for the improvement of hyperphosphatemia in adult patients with CKD on dialysis.

Operating Expenses

Below is a summary of our operating expenses (dollars in thousands):

Research and development
Selling, general and administrative

Total operating expenses

Year Ended December 31,

Change 
2023 vs. 2022

Change 
2022 vs. 2021

2023

2022

2021

35,536 
134,401 
169,937  $

35,201 
76,599 
111,800  —  $

91,140 
72,303 
163,443  $

$

$

335 
57,802 
58,137 

%

1 %
75 %
52 % $

$

(55,939)
4,296 
(51,643)

%

(61)%
6 %

(32)%

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Research and Development

Below is a summary of our research and development expenses (dollars in thousands):

Year Ended December 31,

2023

2022

2021

13,450  $
17,391 

13,378  $
15,065 

56,747  $
27,268 

2,901 
1,794 
35,536  $

3,097 
3,661 
35,201  $

5,803 
1,322 
91,140  $

Change 
2023 vs. 2022

Change 
2022 vs. 2021

$

72 
2,326 

(196)
(1,867)
335 

%

1 % $

15 %

(6)%
(51)%

1 % $

$
(43,369)
(12,203)

(2,706)
2,339 
(55,939)

%

(76)%
(45)%

(47)%
177 %

(61)%

External R&D expenses
Employee-related expenses
Facilities, equipment and depreciation
expenses
Other

Total research and development expenses

$

$

Fiscal 2023 compared to 2022:

The change in our R&D expenses for the year ended December 31, 2023 as compared to the same period in 2022 is primarily the result of clinical trial and
pharmacovigilance activities related to IBSRELA.

Fiscal 2022 compared to 2021:

The decrease in our external R&D expenses for the year ended December 31, 2022 as compared to the same period in 2021 was primarily the result of
lower  clinical  study  costs  following  the  completion  of  the  OPTIMIZE  study,  lower  tenapanor  manufacturing  expense  as  we  began  to  capitalize  costs
associated with the production of IBSRELA to inventory, and lower expenses for research following the elimination of our internal research organization in
the fourth quarter of 2021. The decrease in our employee-related expenses for the year ended December 31, 2022 is due to lower compensation and benefits
expenses  for  our  research  and  development  workforce  following  restructuring  actions  in  2021.  Similarly,  the  decrease  in  facilities,  equipment  and
depreciation expenses is primarily due to a smaller proportion of such expenses being attributed to R&D following the restructuring in 2021. The increase
in other expenses is primarily related to disease-related education grants during the year ended December 31, 2022.

Selling, General and Administrative

Fiscal 2023 compared to 2022:

The increase in selling, general and administrative expenses for the year ended December 31, 2023 as compared to the same period in 2022 is primarily due
to increased costs associated with the commercial launches of IBSRELA and XPHOZAH and increases in expenses associated with administrative support
functions  as  our  company  has  grown  in  headcount  and  activity  level.  The  increases  consisted  of  headcount  and  related  personnel  costs  and  external
spending for disease awareness initiatives, commercial infrastructure and strategy.

Fiscal 2022 compared to 2021:

The increase in selling, general and administrative expenses for the year ended December 31, 2022 as compared to the same period in 2021 was primarily
due to increased costs associated with the commercial launch of IBSRELA. The changes consisted of headcount and related personnel costs and external
spending for disease awareness initiatives, commercial infrastructure and strategy. These increases were partially offset by a reduction in ongoing costs as a
result of the restructuring action carried out during the third quarter of 2021.

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Interest Expense

Below is a summary of our interest expense (dollars in thousands):

Interest expense

$

(4,950) $

(3,400) $

(4,502) $

Year Ended December 31,

2023

2022

2021

Change 
2023 vs. 2022

Change 
2022 vs. 2021

$
(1,550)

%

45.6 % $

$
1,102 

%
(24.5)%

Fiscal 2023 compared to 2022:

The increase in interest expense for the year ended December 31, 2023 as compared to the same period in 2022 is due to a higher variable interest rate
applied to our loan balance primarily resulting from market fluctuations, as well as a larger loan balance outstanding following the draw of an additional
$22.5 million for the Term B Loan in October 2023.

Fiscal 2022 compared to 2021:

The decrease in interest expense for the year ended December 31, 2022 as compared to the same period in 2021 was due to lower principal outstanding on
our loan payable in 2022 than in 2021 due to principal payments made on our 2018 Loan during the fourth quarter of 2021 through February 2022. In
February 2022, we repaid the remaining outstanding principal balance of the 2018 Loan in the amount of $25.0 million and entered into the new 2022 Loan
in the amount of $27.5 million.

Non-Cash Interest Expense Related to the Sale of Future Royalties

Below is a summary of our non-cash interest expense related to the sale of future royalties (dollars in thousands):

Year Ended December 31,

Change 
2023 vs. 2022

Change 
2022 vs. 2021

2023

2022

2021

$

%

$

%

(3,924) $

(1,673) $

—  $

(2,251)

135 % $

(1,673)

(a)

Non-cash interest expense related to the sale of
future royalties
(a) Percent change is not meaningful.

$

Fiscal 2023 compared to 2022:

Non-cash interest expense related to the sales of future royalties for the year ended December 31, 2023 is accrued on the deferred royalty obligation that we
recorded following the receipt of the $10.0 million upfront payment and the $5.0 million milestone payment received from HCR during June 2022 and
October  2023,  respectively.  We  recognized  a  full  twelve  months  of  expense  during  the  year  ended  December  31,  2023  compared  to  approximately  six
months of expense during the year ended December 31, 2022.

Fiscal 2022 compared to 2021:

Non-cash  interest  expense  related  to  the  sale  of  future  royalties  reflects  the  recognized  amortization  of  the  deferred  royalty  obligation  that  we  recorded
following the receipt of the $10.0 million upfront payment from HCR in June 2022.

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Other Income, net

Below is a summary of our other income, net (dollars in thousands):

Year Ended December 31,

Change 
2023 vs. 2022

Change 
2022 vs. 2021

2023

2022

2021

$

6,630  $

1,633  $

687  $

$
4,997 

%

$

%

306 % $

946 

138 %

Other income, net

Fiscal 2023 compared to 2022:

The increase in other income, net for the year ended December 31, 2023 as compared to the same period in 2022 is primarily due to increased income on
our investments resulting from both higher interest rates and larger investment balances throughout the period.

Fiscal 2022 compared to 2021:

The increase in other income, net for the year ended December 31, 2022 as compared to the same period in 2021 was primarily due to sales of certain lab
equipment and supplies for a net gain of $1.5 million and increased investment income during the year ended December 31, 2022. Partially offsetting these
increases were fluctuations related to revaluation of our exit fees.

LIQUIDITY AND CAPITAL RESOURCES

Below is a summary of our cash, cash equivalents and short-term investments (in thousands):

Cash and cash equivalents
Short-term investments

Total liquid funds

Year Ended December 31,

2023

2022

$

$

21,470  $
162,829 
184,299  $

96,140  $
27,769 
123,909  $

Change 
2023 vs. 2022

$
(74,670)
135,060 
60,390 

%

(78)%
486 %

49 %

As of December 31, 2023, we had cash, cash equivalents and short-term investments of approximately $184.3 million.

In August 2021, we filed a prospectus supplement under a Registration Statement which was filed in July 2020 for the offering, issuance and sale by us of
up to a maximum aggregate offering price of $150.0 million of our common stock that was authorized for issuance and sale, from time to time, under a
sales agreement (2021 Open Market Sales Agreement) we entered into with Jefferies LLC (Jefferies), pursuant to which we, from time to time, sold up to
$150.0 million in shares of our common stock through Jefferies. Pursuant to the 2021 Open Market Sales Agreement, Jefferies, as our sales agent, received
a commission of up to 3.0% of the gross sales price for shares of common stock sold under the 2021 Open Market Sales Agreement. As of March 2023, we
had  received  the  maximum  gross  proceeds  of  $150.0  million  under  the  2021  Open  Market  Sales  Agreement  at  a  weighted  average  share  price  of
approximately  $1.57  per  share,  which  included  15.5  million  shares  of  our  common  stock  for  which  we  received  gross  proceeds  of  $51.9  million  at  a
weighted average share price of approximately $3.35 during the quarter ended March 31, 2023.

In January 2023, we filed a Form S-3 Registration Statement, which became effective in January 2023 (2023 Registration Statement), containing (i) a base
prospectus for the offering, issuance and sale by us of up to a maximum aggregate offering price of $250.0 million of our common stock, preferred stock,
debt securities, warrants and/or units, from time to time in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by us
of  up  to  a  maximum  aggregate  offering  price  of  $150.0  million  of  our  common  stock  that  may  be  issued  and  sold,  from  time  to  time,  under  a  sales
agreement  with  Jefferies,  deemed  to  be  “at-the-market  offerings”  (2023  Open  Market  Sales  Agreement).  Pursuant  to  the  2023  Open  Market  Sales
Agreement, Jefferies, as sales agent, may receive a commission of up to 3.0% of the gross sales price for shares of common stock sold under the 2023 Open
Market Sales Agreement. During the year ended December 31, 2023, we completed sales pursuant to the 2023 Open Market Sales Agreement resulting in
the issuance of 16.8 million shares of our common stock and receipt of gross proceeds of $70.0 million at a weighted average sales price of approximately
$4.17 per share.

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In February 2022, we entered into a loan and security agreement (2022 Loan Agreement) with SLR Investment Corp (SLR). The 2022 Loan Agreement
was  subsequently  amended  on  August  1,  2022  and  February  9,  2023.  The  2022  Loan  Agreement  as  amended  through  February  9,  2023  provides  for  a
senior secured term loan facility, with $27.5 million funded at closing (the Term A Loan) and an additional $22.5 million that we could borrow on or prior
to December 20, 2023; provided that (i) we received approval by the U.S. FDA for our NDA for XPHOZAH by November 30, 2023 and (ii) we achieved
certain product revenue milestone targets described in the 2022 Loan Agreement (the Term B Loan).

The initial funding of $27.5 million was used to repay the 2018 Loan and is funding our ongoing operations. We had $25.0 million principal from the 2018
Loan outstanding as of the closing date, as well as the 2018 Exit Fee in the amount of $1.5 million. We paid the 2018 Exit Fee in October 2023 following
approval from the U.S. FDA for XPHOZAH to reduce serum phosphorus in adults with chronic kidney disease (CKD) on dialysis as add-on therapy in
patients who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy. As discussed in Note  10.
Derivative Liabilities, in connection with entering into the 2022 Loan Agreement, we entered into the 2022 Exit Fee agreement, as amended, whereby we
agreed  to  pay  an  exit  fee  in  the  amount  of  2%  of  the  amounts  funded  for  the  Term  A  Loan  and  Term  B  Loan  by  SLR  if  certain  conditions  are  met.
Notwithstanding the prepayment or termination of the 2022 Loan, the 2022 Exit Fee will expire on February 23, 2032.

In October 2023, we entered into a Third Amendment (the Third Amendment) to the 2022 Loan Agreement by and between us and the 2022 Lenders. As
discussed  in  Note  9.  Borrowing,  the  Third  Amendment,  among  other  things,  (1)  provides  us  with  the  option  to  draw  an  additional  $50.0  million  of
committed capital by March 15, 2024 (the Term C Loan); (2) provides us with the option to draw up to an additional $50.0 million of uncommitted capital,
subject to approval by the Agent's investment committee (the Term D Loan); and (3) extends the interest-only period for the Four Loans to December 31,
2026, effective upon our decision to draw the Term B Loan in the amount of $22.5 million. In October 2023, we provided the Agent with notice of our
decision to draw the Term B Loan to support the commercial launch of XPHOZAH and received the proceeds of the Term B Loan. We expect to provide
the Agent with notice of our decision to draw the Term C Loan prior to the expiry of the option on March 15, 2024 to further support the commercial
launch of XPHOZAH.

In October 2022, we announced that our collaboration partner, Kyowa Kirin, submitted an NDA to the Japanese MHLW for tenapanor for the improvement
of hyperphosphatemia in adult patients with CKD on dialysis. In accordance with the terms of the 2022 Amendment, Kyowa Kirin paid an aggregate of
$35.0 million to us in milestone payments and payments associated with the 2022 Amendment during the quarter ended December 31, 2022.

In  September  2023,  we  announced  that  Kyowa  Kirin  received  approval  from  the  Japanese  MHLW  for  the  NDA  for  tenapanor  for  the  improvement  of
hyperphosphatemia in adult patients with chronic kidney disease on dialysis, which resulted in payment to us from Kyowa Kirin for an aggregate of $30.0
million  for  milestone  payments  and  payments  under  the  2022  Amendment  and  entitled  us  to  a  $5.0  million  payment  under  the  terms  of  the  HCR
Agreement. We received these payments in October 2023.

We have incurred operating losses since inception in 2007 and our accumulated deficit as of December 31, 2023 is $846.2 million. Our primary sources of
cash have been from the sale and issuance of common stock (in both public offerings and private placements), private placements of convertible preferred
stock, funds from our collaboration partnerships, funds from our 2018 Loan Agreement, as amended, and 2022 Loan Agreement, as amended, as well as
from  sales  of  IBSRELA  and  XPHOZAH.  Our  primary  uses  of  cash  have  been  to  fund  operating  expenses,  including  research  and  development
expenditures, pre-commercial and commercial expenses. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses,
as reflected in the change in our outstanding accounts payable and accrued expenses.

Between December 31, 2021 and September 30, 2023, our liquidity position raised substantial doubt about our ability to continue as a going concern. We
have addressed our operating cash flow requirements through cash generated from product sales of IBSRELA and XPHOZAH, proceeds from the sale of
shares of our common stock under our at-the-market offering, from the receipt of milestones payments from our collaboration partners and payments from
Kyowa Kirin under the 2022 Amendment to our License Agreement, which were received in October 2023, and from proceeds of the Term B Loan. We
believe our available cash, cash equivalents and short-term investments as of December 31, 2023 will be sufficient to fund our planned operations for at
least a period of one year from the issuance of these financial statements. We have based this estimate on assumptions that may prove to be wrong, and we
could utilize our available capital resources sooner than we currently expect. In particular, our operating plan may change and we may require significant
additional capital to fund our operations. There are no assurances that our efforts to meet our operating cash flow requirements will be successful. If our
current  cash,  cash  equivalents  and  short-term  investments  as  well  as  our  plans  to  meet  our  operating  cash  flow  requirements  are  not  sufficient  to  fund
necessary  expenditures  and  meet  our  obligations  following  the  issuance  of  these  financial  statements,  our  liquidity,  financial  condition  and  business
prospects will be materially affected.

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Our future funding requirements will depend on many factors, including, but not limited to:

•

•

•

the extent to which we are able to generate product revenue from sales of IBSRELA and XPHOZAH;

the availability of adequate third-party reimbursement for IBSRELA and XPHOZAH;

the manufacturing, selling and marketing costs associated with IBSRELA and XPHOZAH;

• whether or when XPHOZAH, along with other oral ESRD-related drugs without an injectable or intravenous equivalent, are bundled into the ESRD

prospective payment system (ESRD PPS), the manner in which such introduction into the ESRD PPS may occur, including the length of any
applicable TDAPA period and the amount of the add-on payment available during the TDAPA period and whether, and the extent to which, the ESRD
PPS base rate is adjusted following any applicable TDAPA period;

•

•

•

•

•

•

•

our ability to maintain our existing collaboration partnerships and to establish additional collaboration partnerships, in-license/out-license, joint
ventures or other similar arrangements and the financial terms of such agreements;

the timing, receipt and amount of any milestones that may be received from our collaboration partners in connection with tenapanor, if any;

the timing, receipt, and amount of royalties we may receive as a result of sales of tenapanor by our collaboration partners in China, and Canada, if any;

the cash requirements for the discovery and/or development of other potential product candidates, including RDX013 and RDX020;

the time and cost necessary to respond to technological and market developments;

the costs of filing, prosecuting, maintaining, defending, and enforcing any patent claims and other intellectual property rights, including litigation costs
and the outcome of such litigation, and costs of defending any claims of infringement brought by others in connection with the development,
manufacture or commercialization of tenapanor or any of our product candidates; and

the payment of interest and principal related to the 2022 Loan Agrememt, as amended to date.

Please see the risk factors set forth in Part I, Item 1A, Risk Factors, in this Annual Report on Form 10-K for additional risks associated with our capital
requirements.

CASH FLOW ACTIVITIES

The following table summarizes our cash flows for the periods indicated (in thousands):

Year Ended December 31,

Change 
2023 vs. 2022

Change 
2022 vs. 2021

2023
(89,717) $

2022
(70,044) $

2021
(152,551) $

$

$

(19,673)

%

28 % $

(131,248)
146,295 

18,415 
75,341 

50,948 
82,999 

(149,663)
70,954 

(813)%
94 %

$
82,507 

(32,533)
(7,658)

%

(54)%

(64)%
(9)%

$

(74,670) $

23,712  $

(18,604) $

(98,382)

(415)% $

42,316 

(227)%

Net cash used in operating activities
Net cash (used in) provided by investing
activities
Net cash provided by financing activities
Net (decrease) increase in cash and cash
equivalents

Cash Flows from Operating Activities

Fiscal 2023 compared to 2022:

Net  cash  used  in  operating  activities  during  the  year  ended  December  31,  2023  increased  by  $19.7  million  as  compared  to  the  same  period  in  2022
primarily as a result of changes in our working capital, including a $13.8 million increase in prepaid expenses primarily related to the timing of upfront
payments to contract manufacturing organizations for the commercial manufacturing for the production of IBSRELA and XPHOZAH.

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Fiscal 2022 compared to 2021:

Net  cash  used  in  operating  activities  during  the  year  ended  December  31,  2022  decreased  as  compared  to  the  same  period  in  2021  by  $82.5  million
primarily as a result of decreased spending on research and development expenses during the year ended December 31, 2022 as compared to the year ended
December 31, 2021, as well net product sales of IBSRELA and $35.0 million of milestone payments and payments under the 2022 Amendment, which we
earned in 2022 upon Kyowa Kirin's submission of a New Drug Application to the Japanese Ministry of Health, Labour and Welfare for tenapanor for the
improvement of hyperphosphatemia in adult patients with CKD on dialysis. Partially offsetting the net loss improvement were changes to our operating
assets and liabilities related to expenditures for commercial manufacturing and inventory for the production of IBSRELA.

Cash Flows from Investing Activities

Fiscal 2023 compared to 2022:

Net cash provided by investing activities during the year ended December 31, 2023 decreased as compared to the same period in 2022 by $149.7 million
primarily due to increased investment purchases during 2023, as we invested higher levels of cash as compared to the same period in 2022. The decrease
due to investment purchases of $215.3 million was partially offset by investment maturities and redemptions of $84.3 million,

Fiscal 2022 compared to 2021:

Net cash provided by investing activities during the year ended December 31, 2022 decreased as compared to the same period in 2021 by $32.5 million due
to  lower  investment  balances  and  the  timing  of  our  investment  maturities,  which  was  partially  offset  by  $1.8  million  proceeds  from  sale  of  laboratory
equipment and supplies during the year ended December 31, 2022.

Cash Flows from Financing Activities

Fiscal 2023 compared to 2022:

Net cash provided by financing activities during the year ended December 31, 2023 increased by $71.0 million as compared to the same period in 2022
primarily  due  to  net  proceeds  from  issuance  of  our  common  stock  pursuant  to  the  at  the  market  offerings  of  $119.2  million  during  the  year  ended
December 31, 2023 compared to $71.6 million during the year ended December 31, 2022, as well as net proceeds received of $22.4 million from drawing
the Term B Loan as compared to net expenditure of $6.1 million during the year ended December 31, 2022 in conjunction with entering into the 2022 Loan
and repaying the principal outstanding under the 2018 Loan. In addition we received net proceeds of $5.0 million from the sale of future royalties to HCR
during the year ended December 31, 2023 as compared to $10.0 million during the year ended December 31, 2022.

Fiscal 2022 compared to 2021:

Net cash provided by financing activities during the year ended December 31, 2022 decreased as compared to the same period in 2021 by $7.7 million
primarily due to $29.5 million lower proceeds from issuance of common stock under at-the-market offerings and well as increased payments in the amount
of $13.6 million to repay the principal outstanding on the 2018 Loan. Partially offsetting these amounts were $27.0 million net proceeds received from the
2022 Loan and $9.6 million net proceeds from the sales of future royalties during the year ended December 31, 2022.

SMALLER REPORTING COMPANY AND LARGE ACCELERATED FILER STATUS

As  a  non-accelerated  filer,  we  were  not  required  to  obtain  an  opinion  of  our  independent  auditors  with  respect  to  our  internal  controls  over  financial
reporting for the year ended December 31, 2022. On June 30, 2023, our public float exceeded $700.0 million and therefore, as of January 1, 2024, we are
considered a large accelerated filer and we will be required to reflect the determination that we are no longer a smaller reporting company in our Quarterly
Report on Form 10-Q for the fiscal quarter ending March 31, 2024. This Annual Report on Form 10-K includes an opinion of Ernst & Young LLP, our
independent auditors with respect to our internal control over financial reporting as of December 31, 2023.

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ITEM 7A.    QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Interest Rate Risk

We are subject to market risks, including interest rate fluctuation exposure through our investments, in the ordinary course of our business. However, the
goals  of  our  investment  policy  are  the  preservation  of  capital,  fulfillment  of  liquidity  needs  and  fiduciary  control  of  cash.  To  achieve  our  goal  of
maximizing income without assuming significant market risk, we maintain our excess cash and cash equivalents in money market funds and short-term
debt securities. Because of the short-term maturities of our cash equivalents, we do not believe that a decrease in interest rates would have any material
negative impact on the fair value of our cash equivalents and short-term investments.

As of December 31, 2023, we had cash, cash equivalents and short-term investments of $184.3 million, which consist of bank deposits and money market
funds, as well as high quality fixed income instruments including commercial paper, U.S. government-sponsored agency bonds, corporate bonds and asset-
backed securities. The credit rating of our short-term investments must be rated A-1/P-1, or better by Standard and Poor’s and Moody’s Investors Service.
Asset-backed securities must be rated AAA/Aaa. Money Market funds must be rated AAA/Aaa. Such interest-earning instruments carry a degree of interest
rate risk. However, because our investments are high quality and short-term in duration, we believe that our exposure to interest rate risk is not significant
and that a 10% movement in market interest rates would not have a significant impact on the total value of our portfolio, as noted above. We do not enter
into investments for trading or speculative purposes.

We are subject to interest rate fluctuation exposure through our borrowings under the Loan Agreement and our investment in money market accounts which
bear a variable interest rate. Borrowings under the 2022 Loan as amended bear interest at a floating per annum interest rate with 7.95% plus the greater of
(a)  one  percent  (1.00%)  per  annum  and  (b)(i)  0.022%  plus  (ii)  1-month  CME  Term  SOFR  reference  rate  as  published  by  the  CME  Term  SOFR
Administrator on the CME Term SOFR Administrator’s Website. A hypothetical increase in one-month CME Term SOFR of 100 basis points above the
current one-month CME Term SOFR rate would have increased our interest expense by approximately $0.3 million for the year ended December 31, 2023.
As of December 31, 2023, we had an aggregate principal amount of $50.0 million outstanding pursuant to our 2022 Loan Agreement.

Foreign Currency Exchange Risk

The majority of our transactions are denominated in U.S. dollars. However, we do have certain transactions that are denominated in currencies other than
the U.S. dollar, primarily Swiss francs and the euro, and we therefore are subject to foreign exchange risk. The fluctuation in the value of the U.S. dollar
against other currencies affects the reported amounts of expenses, assets and liabilities associated with a limited number of manufacturing activities.

We do not use derivative financial instruments for speculative trading purposes, nor do we hedge foreign currency exchange rate exposure in a manner that
entirely offsets the earnings effects of changes in foreign currency exchange rates. The counterparties to our forward foreign currency exchange contracts
are creditworthy commercial banks, which minimizes the risk of counterparty nonperformance.

As of December 31, 2023, we had no open forward foreign currency exchange contracts.

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ITEM 8.    FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

ARDELYX, INC.
INDEX TO FINANCIAL STATEMENTS

Report of Independent Registered Public Accounting Firm (PCAOB ID: 42)

Balance Sheets

Statements of Operations and Comprehensive Loss

Statements of Stockholders’ Equity

Statements of Cash Flows

Notes to Financial Statements

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77

78

79

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Report of Independent Registered Public Accounting Firm

To the Stockholders and the Board of Directors of Ardelyx, Inc.

Opinion on the Financial Statements

We  have  audited  the  accompanying  balance  sheets  of  Ardelyx,  Inc.  (the  “Company”)  as  of  December  31,  2023  and  2022,  the  related  statements  of
operations and comprehensive loss, stockholders’ equity, and cash flows for each of the three years in the period ended December 31, 2023, and the related
notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial
position of the Company as of December 31, 2023 and 2022, and the results of its operations and its cash flows for each of the three years in the period
ended December 31, 2023, in conformity with U.S. generally accepted accounting principles.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”), the Company's
internal control over financial reporting as of December 31, 2023, based on criteria established in Internal Control—Integrated Framework issued by the
Committee of Sponsoring Organizations of the Treadway Commission (2013 Framework) and our report dated February 22, 2024 expressed an unqualified
opinion thereon.

Basis for Opinion

These financial statements are the responsibility of the Company‘s management. Our responsibility is to express an opinion on the Company‘s financial
statements  based  on  our  audits.  We  are  a  public  accounting  firm  registered  with  the  PCAOB  and  are  required  to  be  independent  with  respect  to  the
Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the
PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance  about  whether  the  financial  statements  are  free  of  material  misstatement,  whether  due  to  error  or  fraud.  Our  audits  included  performing
procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to
those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits
also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the
financial statements. We believe that our audits provide a reasonable basis for our opinion.

Critical Audit Matter

The  critical  audit  matter  communicated  below  is  a  matter  arising  from  the  current  period  audit  of  the  financial  statements  that  was  communicated  or
required to be communicated to the audit committee and that: (1) relates to accounts or disclosures that are material to the financial statements and (2)
involved our especially challenging, subjective or complex judgments. The communication of the critical audit matter does not alter in any way our opinion
on the financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing a separate opinion on the critical
audit matter or on the accounts or disclosures to which it relates.

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Table of Contents

Description of the Matter

Estimates of Reserves for Variable Consideration Impacted by Estimated Payor Mix

As  described  in  Note  2  to  the  financial  statements,  the  Company  recognizes  revenues  from
product  sales  at  the  net  sales  price  (transaction  price),  which  includes  estimates  of  variable
consideration relating to off-invoice discounts, chargebacks or rebates, wholesaler fees, group
purchasing organization administrative fees, patient copay assistance programs, and estimated
product returns. The variable consideration is based on the amounts earned or to be claimed for
related sales which may not be known at the point of sale. Government-mandated rebates under
the  Medicaid  Drug  Rebate  Program  (“Medicaid”)  and  the  Medicare  Coverage  Gap  Program
(“Medicare”) are estimated based on estimated payor mix and statutory discount rates. Patient
copay assistance program amounts are estimated based on payor mix consideration, the terms
of  the  program  and  redemption  information  provided  by  third-party  claims  processing
organizations.  The  Company’s  total  estimate  of  reserves  for  variable  consideration  was  $8.6
million as of December 31, 2023. During 2023, the Company recorded $31.3 million in total
reductions to gross commercial product sales as a result of reserves for variable consideration.

Auditing the Company’s estimates of reserves for variable consideration relating to Medicaid
and  Medicare  claims  and  patient  copay  assistance  was  especially  challenging  as  it  involved
evaluation of management’s subjective judgments with respect to payor mix that is developed
based  on  various  data  sources.  The  Company  has  a  limited  history  upon  which  to  base  its
assumptions, and changes in these assumptions could have a material impact on the amount of
reserves recorded for variable consideration.

How We Addressed the Matter in Our
Audit

We obtained an understanding, evaluated the design and tested the operating effectiveness of
internal  controls  over  the  Company’s  process  to  determine  the  reserves  for  variable
consideration  that  are  impacted  by  the  payor  mix.  For  example,  we  tested  controls  over
management’s  review  of  the  completeness  and  accuracy  of  the  data  used  to  determine  the
estimate.

To test the Company’s estimates of reserves for variable consideration relating to Medicaid and
Medicare  claims  and  patient  copay  assistance,  our  audit  procedures  included,  among  others,
evaluating the methodologies and assumptions used and testing the accuracy and completeness
of  the  underlying  data  used  in  the  Company’s  payor  mix  analysis.  We  compared  the
assumptions  used  by  management  to  third-party  industry  data  and  actual  trends.  We  also
evaluated the reasonableness of changes in estimated reserves during the year, and assessed the
accuracy  of  the  Company’s  estimates  against  actual  results.  We  also  performed  sensitivity
analyses  to  determine  the  effect  of  changes  in  management’s  assumptions  on  the  amount  of
reserves  recorded  for  variable  consideration  impacted  by  the  payor  mix,  where  appropriate.
Further,  we  evaluated  the  appropriateness  of  classification  and  disclosure  of  the  Company’s
reserves for variable consideration in the financial statements.

/s/ Ernst & Young LLP

We have served as the Company’s auditor since 2009.

Boston, MA

February 22, 2024

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Assets

Current assets:

Cash and cash equivalents

Short-term investments

Accounts receivable

Inventory

Prepaid commercial manufacturing

Prepaid expenses and other current assets

Total current assets

Property and equipment, net

Inventory, non-current

Prepaid commercial manufacturing, non-current

Right-of-use assets

Other assets

Total assets

Liabilities and stockholders’ equity

Current liabilities:

Accounts payable

Accrued compensation and benefits

Current portion of operating lease liability

Current portion of long-term debt

Deferred revenue

Accrued expenses and other current liabilities

Total current liabilities

Operating lease liability, net of current portion

Long-term debt, net of current portion

Deferred revenue, non-current

ARDELYX, INC.
BALANCE SHEETS
(in thousands, except share and per share amounts)

December 31,

2023

2022

$

21,470  $

162,829 

22,031 

12,448 

18,925 

8,408 

246,111 

1,009 

37,039 

4,235 

5,589 

3,596 

96,140 

27,769 

7,733 

3,282 

13,567 

5,112 

153,603 

1,223 

25,064 

— 

9,295 

881 

297,579  $

190,066 

$

$

11,138  $

12,597 

4,435 

— 

7,182 

15,041 

50,393 

1,725 

49,822 

8,644 

20,179 

130,763 

— 

23 

1,012,773 

(846,204)

224 

166,816 

$

297,579  $

10,859 

7,548 

3,894 

26,711 

4,211 

12,380 

65,603 

5,855 

— 

9,025 

11,254 

91,737 

— 

20 

878,500 

(780,137)

(54)

98,329 

190,066 

Deferred royalty obligation related to the sale of future royalties

Total liabilities

Commitments and contingencies (Note 20)

Stockholders’ equity:

Preferred stock, $0.0001 par value; 5,000,000 shares authorized; no shares issued and outstanding

Common stock, $0.0001 par value; 500,000,000 and 300,000,000 shares authorized; 232,453,190 and 198,575,016
shares issued and outstanding as of December 31, 2023 and December 31, 2022, respectively.

Additional paid-in capital

Accumulated deficit

Accumulated other comprehensive income (loss)

Total stockholders’ equity

Total liabilities and stockholders’ equity

The accompanying notes are an integral part of these financial statements.

76

ARDELYX, INC.
STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(in thousands, except share and per share amounts)

Table of Contents

Revenues:

Product sales, net
Licensing revenue
Product supply revenue
Collaborative development revenue

Total revenues

Cost of goods sold:

Cost of product sales
Other cost of revenue

Total cost of goods sold

Operating expenses:

Research and development
Selling, general and administrative

Total operating expenses

Loss from operations
Interest expense
Non-cash interest expense related to the sale of future royalties
Other income, net

Loss before provision for income taxes
Provision for income taxes

Net loss

Net loss per share of common stock - basic and diluted

Shares used in computing net loss per share - basic and diluted
Comprehensive loss:
Net loss
Unrealized gains (losses) on available-for-sale securities

Comprehensive loss

Year Ended December 31,

2023

2022

2021

82,526  $
35,809 
6,121 
— 
124,456 

2,323 
15,472 
17,795 

35,536 
134,401 
169,937 
(63,276)
(4,950)
(3,924)
6,630 
(65,520)
547 
(66,067) $

(0.30) $

15,600  $
35,031 
1,527 
— 
52,158 

566 
3,551 
4,117 

35,201 
76,599 
111,800 
(63,759)
(3,400)
(1,673)
1,633 
(67,199)
8 

(67,207) $

(0.42) $

— 
5,013 
907 
4,177 
10,097 

— 
1,000 
1,000 

91,140 
72,303 
163,443 
(154,346)
(4,502)
— 
687 
(158,161)
4 
(158,165)

(1.52)

219,331,253 

158,690,083 

104,205,645 

(66,067) $
278 
(65,789) $

(67,207) $
(48)
(67,255) $

(158,165)
(2)
(158,167)

$

$

$

$

$

The accompanying notes are an integral part of these financial statements.

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Table of Contents

ARDELYX, INC.
STATEMENTS OF STOCKHOLDERS’ EQUITY
(in thousands, except share amounts)

Balance as of December 31, 2020

93,599,975 

$

9 

$

680,872 

$

(554,765)

$

(4)

$

126,112 

Common Stock

Shares

Amount

Additional
Paid-In
Capital

Accumulated
Deficit

Accumulated
Other
Comprehensive
(Loss) Income

Total
Stockholders'
Equity

Issuance of common stock under employee
stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise of
options
Issuance of common stock upon vesting of
restricted stock units
Taxes paid for net share settlement of equity
awards
Issuance of common stock in at the market
offering
Stock-based compensation
Unrealized losses on available-for-sale
securities
Net loss

386,664 
25,989 

331,310 

167,158 

— 

35,671,439 
— 

— 
— 

Balance as of December 31, 2021

130,182,535 

$

Issuance of common stock under employee
stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise of
options
Issuance of common stock upon vesting of
restricted stock units
Issuance of common stock in at the market
offering
Stock-based compensation
Unrealized losses on available-for-sale
securities
Net loss

308,356 
711,675 

14,080 

3,243,828 

64,114,542 
— 

— 
— 

Balance as of December 31, 2022

198,575,016 

$

Issuance of common stock under employee
stock purchase plan
Issuance of common stock for services
Issuance of common stock upon exercise of
options
Issuance of common stock upon vesting of
restricted stock units
Issuance of common stock in at the market
offering
Stock-based compensation
Unrealized gains on available-for-sale
securities
Net loss

435,708 
86,095 

225,988 

855,642 

32,274,741 
— 

— 
— 

Balance as of December 31, 2023

232,453,190 

$

— 
— 

— 

— 

— 

4 
— 

— 
— 

13 

— 
— 

— 

— 

7 
— 

— 
— 

20 

— 
— 

— 

— 

3 
— 

— 
— 

23 

819 
190 

584 

— 

(106)

101,142 
12,039 

— 
— 

— 
— 

— 

— 

— 

— 
— 

— 
(158,165)

$

795,540 

$

(712,930)

$

195 
390 

7 

— 

71,618 
10,750 

— 
— 

— 
— 

— 

— 

— 
— 

— 
(67,207)

$

878,500 

$

(780,137)

$

808 
337 

365 

— 

119,233 
13,530 

— 
— 

— 
— 

— 

— 

— 
— 

— 
(66,067)

$

1,012,773 

$

(846,204)

$

— 
— 

— 

— 

— 

— 
— 

(2)
— 

(6)

— 
— 

— 

— 

— 
— 

$

(48)
— 

(54)

$

— 
— 

— 

— 

— 
— 

278 
— 

224 

$

819 
190 

584 

— 

(106)

101,146 
12,039 

(2)
(158,165)

82,617 

195 
390 

7 

— 

71,625 
10,750 

(48)
(67,207)

98,329 

808 
337 

365 

— 

119,236 
13,530 

278 
(66,067)

166,816 

The accompanying notes are an integral part of these financial statements.

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ARDELYX, INC.
STATEMENTS OF CASH FLOWS
(in thousands)

Operating activities

Net loss
Adjustments to reconcile net loss to net cash used in operating activities:

Year Ended December 31,

2023

2022

2021

$

(66,067)

$

(67,207)

$

(158,165)

Depreciation and amortization expense
Non-cash lease expense
Stock-based compensation
Non-cash interest expense
Gain on sale of equipment
Other, net
Changes in operating assets and liabilities:

Accounts receivable
Inventory
Prepaid commercial manufacturing
Prepaid expenses and other assets
Accounts payable
Accrued compensation and benefits
Operating lease liabilities
Accrued and other liabilities
Deferred revenue

Net cash used in operating activities
Investing activities

Proceeds from maturities and redemptions of investments
Purchases of investments
Proceeds from sale of property and equipment
Purchases of property and equipment

Net cash (used in) provided by investing activities
Financing activities

Proceeds from issuance of common stock in at the market offering, net of issuance costs
Proceeds from 2022 Loan, net of issuance costs
Proceeds from the sale of future royalties, net of issuance costs
Proceeds from issuance of common stock under equity incentive and stock purchase plans
Payment of the 2018 Exit Fee
Payments for the 2018 Loan, net of costs
Payments for taxes related to net share settlement of equity awards

Net cash provided by financing activities

Net (decrease) increase in cash and cash equivalents
Cash and cash equivalents at beginning of period

Cash and cash equivalents at end of period
Supplementary disclosure of cash flow information:

Cash paid for interest
Cash paid for income taxes

Supplementary disclosure of non-cash activities:

Right-of-use assets obtained in exchange for lease obligations
Issuance of common stock for services
Issuance of derivative in connection with issuance of loan payable

1,292 
3,624 
13,530 
4,220 
— 
(2,930)

(14,298)
(21,141)
(9,593)
(6,035)
279 
5,049 
(3,928)
3,691 
2,590 

(89,717)

84,321 
(215,225)
— 
(344)

(131,248)

119,236 
22,386 
5,000 
1,173 
(1,500)
— 
— 

146,295 

(74,670)
96,140 

21,470 

4,240 
51 

339 
337 
— 

$

$
$

$
$
$

$

$
$

$
$
$

1,144 
3,457 
10,750 
1,962 
(1,260)
685 

(7,231)
(28,346)
(4,161)
2,299 
6,582 
2,126 
(3,491)
4,138 
8,509 

(70,044)

67,000 
(50,328)
1,798 
(55)

18,415 

71,625 
26,971 
9,581 
202 
— 
(33,038)
— 

75,341 

23,712 
72,428 

96,140 

2,901 
6 

— 
390 
375 

$

$
$

$
$
$

2,807 
3,085 
12,039 
283 
— 
(678)

(502)
— 
(9,406)
502 
(1,349)
(250)
(2,853)
1,386 
550 

(152,551)

125,550 
(72,735)
— 
(1,867)

50,948 

101,146 
— 
— 
1,403 
— 
(19,444)
(106)

82,999 

(18,604)
91,032 

72,428 

3,469 
4 

1,604 
190 
— 

The accompanying notes are an integral part of these financial statements.

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1. ORGANIZATION AND BASIS OF PRESENTATION

ARDELYX, INC.
NOTES TO FINANCIAL STATEMENTS

Ardelyx, Inc. (Company, we, us or our) is a biopharmaceutical company founded with a mission to discover, develop and commercialize innovative, first-
in-class medicines that meet significant unmet medical needs. We developed a unique and innovative platform that enabled the discovery of new biological
mechanisms and pathways to develop potent and efficacious therapies that minimize the side effects and drug-drug interactions frequently encountered with
traditional,  systemically  absorbed  medicines.  The  first  molecule  we  discovered  and  developed  was  tenapanor,  a  minimally  absorbed,  first-in-class,  oral,
small  molecule  therapy.  Tenapanor,  branded  as  IBSRELA ,  is  approved  in  the  U.S.  for  the  treatment  of  adults  with  irritable  bowel  syndrome  with
constipation (IBS-C). Tenapanor, branded as XPHOZAH , was approved by the U.S. Food and Drug Administration (U.S. FDA) on October 17, 2023, to
reduce  serum  phosphorus  in  adults  with  chronic  kidney  disease  (CKD)  on  dialysis  as  add-on  therapy  in  patients  who  have  an  inadequate  response  to
phosphate binders or who are intolerant of any dose of phosphate binder therapy. We also have a development stage asset, RDX013 for adult patients with
CKD and/or heart failure with hyperkalemia, or elevated serum potassium, and a discovery phase asset, RDX020 for adult patients with metabolic acidosis,
a serious electrolyte disorder, in patients with CKD.

®

®

We operate in one business segment, which is the development and commercialization of biopharmaceutical products.

2.    SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation

The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America
(“U.S. GAAP”).

Use of Estimates

The  preparation  of  financial  statements  in  conformity  with  U.S.  GAAP  requires  management  to  make  estimates  and  judgments  that  affect  the  amounts
reported in the financial statements and accompanying notes thereto. On an ongoing basis, management evaluates its estimates, including those related to
recognition of revenue, clinical trial accruals, contract manufacturing accruals, expected demand for inventory, fair value of assets and liabilities, income
taxes  and  stock-based  compensation.  Management  bases  its  estimates  on  historical  experience  and  on  various  other  market-specific  and  relevant
assumptions that management believes to be reasonable under the circumstances. Actual results could materially differ from those estimates.

Liquidity

As of December 31, 2023, we had cash, cash equivalents and short-term investments of approximately $184.3 million. We have incurred operating losses
since inception in 2007 and our accumulated deficit as of December 31, 2023 is $846.2 million. Since December 31, 2021 and prior to September 30, 2023,
our liquidity position raised substantial doubt about our ability to continue as a going concern. We have addressed our operating cash flow requirements
through cash generated from product sales of IBSRELA and XPHOZAH, proceeds from the sale of shares of our common stock under our at-the-market
offering, from the receipt of milestones payments from our collaboration partners and payments from our Japanese collaboration partner under the second
amendment  to  our  License  Agreement,  and  through  funds  from  our  loan  agreements  with  SLR  Investment  Corp.  (SLR),  as  amended.  We  believe  our
available cash, cash equivalents and short-term investments as of December 31, 2023 will be sufficient to fund our planned operations for at least a period
of one year from the issuance of these financial statements.

Cash and Cash Equivalents

We consider all highly liquid investments purchased with an original maturity date of 90 days or less on the date of purchase to be cash equivalents.

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Short-Term Investments

Short-term investments consist of debt securities classified as available-for-sale and have maturities greater than 90 days, but less than one year, from the
date  of  acquisition.  Short-term  investments  are  carried  at  fair  value  based  upon  quoted  market  prices.  Unrealized  gains  and  losses  on  available-for-sale
securities are included in accumulated other comprehensive income (loss) on our balance sheets. The cost of available-for-sale securities sold is based on
the specific-identification method.

Concentration of Credit Risk

Financial  instruments  that  potentially  subject  us  to  significant  concentrations  of  credit  risk  consist  primarily  of  cash,  cash  equivalents,  short-term
investments and accounts receivable. We are exposed to credit risks in the event of default by the counterparties to the extent of the amount recorded in our
balance sheet. Cash, cash equivalents and short-term investments are invested through banks and other financial institutions in the U.S.

Foreign Currency

We manage our foreign currency exposures with the use of foreign currency purchases. We primarily conduct business in U.S. dollars; however, a portion
of our expense and capital activities are transacted in foreign currencies which are subject to exchange rate fluctuations that can affect cash or earnings. We
have  been  in  a  loss  position  and  therefore  our  primary  objective  is  to  conserve  and  manage  cash.  There  are  generally  two  methods  by  which  we  may
manage the cash flow risk of foreign exchange fluctuations when a contract is signed (i) we can purchase the foreign funds, in full or in part, upon the
execution of the contract, or (ii) we can obtain the right to purchase such funds, in full or in part, at the execution of the contract, i.e., obtain a forward
contract from an appropriate bank, that can be exercised to obtain the currency of interest at a particular point in time. The derivative instruments that we
may use to hedge the exposure shall generally not be designated as cash flow hedges, and as a result, changes in their fair value would be recorded in other
income (expense), net, in our statements of operations and comprehensive loss. The fair values of forward foreign currency exchange contracts would be
estimated using current exchange rates and interest rates and the current creditworthiness of the counterparties is taken into consideration.

Property and Equipment

Property and equipment are stated at cost, less accumulated depreciation and amortization. Depreciation is computed using the straight-line method over
the estimated useful lives of the respective assets, with ranges generally from three to five years. Leasehold improvements are amortized over the lesser of
the estimated useful lives or the related remaining lease term.

Impairment of Long-Lived Assets

The  carrying  values  of  long-lived  assets,  including  property  and  equipment,  are  reviewed  for  impairment  whenever  events  or  changes  in  circumstances
indicate that the asset may not be recoverable. An impairment loss is recognized when the total of estimated future undiscounted cash flows, expected to
result  from  the  use  of  the  asset  and  its  eventual  disposition,  are  less  than  the  asset’s  carrying  amount.  Impairment,  if  any,  would  be  assessed  using
discounted cash flows or other appropriate measures of fair value.

Income Taxes

We use the asset and liability method of accounting for income taxes. Under this method, deferred tax assets and liabilities are determined based on the
differences between the financial reporting and the tax bases of assets and liabilities and are measured using the enacted tax rates and laws that will be in
effect when the differences are expected to reverse. A valuation allowance is provided when it is more likely than not that some portion or all of a deferred
tax asset will not be realized.

Accounts Receivable

Accounts receivable are stated at amortized cost less allowance for credit losses. The allowance for credit losses reflects the best estimate of future losses
over the contractual life of outstanding accounts receivable and is determined on the basis of historical experience, specific allowances for known troubled
accounts, other currently available information including customer financial condition and both current and forecasted economic conditions. To date, we
have  determined  that  an  allowance  for  doubtful  accounts  is  not  required.  As  of  December  31,  2023  our  accounts  receivable  balance  was  comprised  of
$4.9 million from our collaboration agreements and $17.1 million from commercial customers. As of December 31, 2022 our accounts receivable balance
was comprised of $0.7 million from our collaboration agreements and $7.0 million from commercial customers.

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Inventory

We capitalize inventory costs associated with the production of our products after regulatory approval or when, based on management’s judgment, future
commercialization is considered probable and the future economic benefit is expected to be realized. Otherwise, such costs are expensed as research and
development. Prior to the regulatory approval of drug product candidates, we incurred expenses for the manufacture of drug product that could potentially
be available to support the commercial launch of our products or could be sold to our international partners under product supply agreements. We began to
capitalize inventory costs associated with IBSRELA during the fourth quarter of 2021, when our intent to commercialize IBSRELA was established and we
commenced preparation for the commercial launch of IBSRELA, which was when it was determined that the inventory had a probable future economic
benefit.  We  began  to  capitalize  inventory  costs  associated  with  XPHOZAH  during  the  fourth  quarter  of  2023,  following  approval  by  the  U.S.  FDA  to
market XPHOZAH in the U.S., which was when it was determined that the inventory had a probable future economic benefit.

Inventory  is  stated  at  the  lower  of  cost  or  estimated  net  realizable  value  with  cost  determined  under  the  specific  identification  method.  Inventory  costs
include  the  cost  of  materials,  third-party  contract  manufacturing,  third-party  packaging  services,  freight,  labor  costs  for  personnel  involved  in  the
manufacturing process, and indirect overhead costs. We primarily use actual costs to determine the cost basis for inventory. The determination of whether
inventory costs will be realizable requires management review of the expiration dates of IBSRELA and XPHOZAH compared to our forecasted sales. If
actual market conditions are less favorable than projected by management, write-downs of inventory may be required, which would be recorded as cost of
revenue in the statement of operations and comprehensive loss. As of December 31, 2023, we have not recorded any write-offs for excess and obsolete
inventory. A portion of inventory that represents product that is not expected to be sold or used within the next 12 months is classified as non-current on our
balance sheets.

Product Sales, Net

We account for our commercial product sales, net in accordance with Topic 606 – Revenue from Contracts with Customers. We received approval from the
FDA  to  market  IBSRELA  in  the  U.S.  in  September  2019  and  to  market  XPHOZAH  in  the  U.S.  in  October  2023.  We  began  selling  IBSRELA  and
XPHOZAH  in  the  U.S.  in  March  2022  and  November  2023,  respectively.  We  distribute  IBSRELA  principally  through  major  wholesalers,  specialty
pharmacies and group purchasing organizations (GPOs) (collectively, our IBSRELA Customers). XPHOZAH is principally distributed through a specialty
wholesaler  (XPHOZAH  Customer)  to  select  specialty  pharmacies  (collectively,  IBSRELA  Customers  and  XPHOZAH  Customers,  “Customers”).  Our
Customers subsequently sell IBSRELA and XPHOZAH to pharmacies and patients. Separately, we enter into arrangements with third parties that provide
for government-mandated rebates, chargebacks and discounts. Revenue from product sales is recognized when our performance obligations are satisfied,
which is when Customers obtain control of our product and occurs upon delivery.

Reserves for Variable Consideration

Revenues from product sales are recorded at the net sales price (transaction price), which includes estimates of variable consideration which may be settled
in the form of off-invoice discounts, chargebacks, or rebates. Variable consideration includes discounts to customers and government programs, wholesaler
fees, group purchasing organization administrative fees, patient copay assistance, and estimated product returns. These estimates are based on the amounts
earned or to be claimed for related sales and are classified as reductions of gross accounts receivable if settlement is expected to occur through a reduction
in  the  amounts  paid  by  our  Customers  or  a  current  liability  if  settlement  is  expected  to  occur  through  a  payment  from  us.  Where  appropriate,  these
estimates are based on factors such as industry data and forecasted customer buying and payment patterns, our experience, current contractual and statutory
requirements, specific known market events and trends. These reductions to gross sales reflect our best estimates of the amount of consideration to which
we are entitled based on the terms of the contract. Variable consideration is included in the transaction price only to the extent that it is probable that a
significant  reversal  in  the  amount  of  cumulative  revenue  recognized  will  not  occur  when  the  uncertainty  associated  with  the  variable  consideration  is
subsequently  resolved.  Actual  amounts  of  consideration  ultimately  received  may  differ  from  our  estimates.  If  actual  results  in  the  future  vary  from  our
estimates,  we  adjust  these  estimates,  which  would  affect  product  revenue  and  earnings  in  the  period  such  variances  become  known.  As  we  gain  more
experience, estimates will be more heavily based on the expected utilization from historical data we have accumulated since the IBSRELA and XPHOZAH
product launches. Changes in estimates recorded through December 31, 2023 have not been material.

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Rebates: Rebates include wholesaler fees, GPO fees, as well as mandated discounts under the Medicaid Drug Rebate Program (Medicaid) and the Medicare
Coverage Gap Program (Medicare). Estimates for rebates are recorded in the same period the related gross revenue is recognized, resulting in a reduction
of product revenue and the establishment of a current liability which is included in accrued expenses on the balance sheets. We estimate our Medicaid and
Medicare rebates based upon the estimated payor mix, and statutory discount rates. Our estimates for payor mix are guided by payor information received
from  specialty  pharmacies,  expected  utilization  for  wholesaler  sales  to  pharmacies,  and  available  industry  payor  information  and,  therefore,  require  the
most estimation and judgment of our gross to net deductions.

Chargebacks: Chargebacks are discounts that occur when certain contracted purchasers purchase directly from our wholesalers at a discounted price. The
wholesaler, in turn, charges back the difference between the price initially paid to us by the wholesaler and the discounted price paid to the wholesaler by
the contracted purchaser. Amounts for estimated chargebacks are established in the same period that the related gross revenue is recognized, resulting in a
reduction of product revenue and accounts receivable. The accrual for wholesaler chargebacks is estimated based on known chargeback rates, known sales
to wholesalers, and known sales from wholesalers to their chargeback-eligible customers.

Discounts  and  Fees:  Our  payment  terms  are  generally  30  to  60  days.  Wholesalers,  GPOs  and  specialty  pharmacies  are  offered  various  forms  of
consideration, including off-invoice discounts which may be paid to GPOs and specialty pharmacies. Wholesalers and GPOs may also receive prompt pay
discounts  for  payment  within  a  specified  period.  We  expect  discounts  to  be  earned  when  offered  and,  therefore,  we  deduct  the  full  amount  of  these
discounts from product sales when revenue is recognized, resulting in a reduction of product revenue and accounts receivable.

Other Reserves: Patients who have commercial insurance may receive copay assistance when product is dispensed by pharmacies to patients. We estimate
the amount of copay assistance provided to eligible patients based on the terms of the program, and redemption information provided by third-party claims
processing organizations. We also estimate the amount of copay assistance that will be provided to patients associated with product which we have sold but
which  has  not  yet  been  dispensed  to  commercial  patients,  which  requires  significant  estimation  and  judgment.  Our  estimates  are  recorded  in  accounts
payable and accrued expenses and other current liabilities on the balance sheets. Other reserves include estimated product returns which are recorded in the
same period the related gross revenue is recognized, resulting in a reduction of product revenue as well as accounts receivable. We estimate our product
returns reserve based upon our experience and specific known market events and trends. As we have experienced limited product returns, establishing the
appropriate level of returns reserve require estimation and judgment.

Collaboration Revenue Recognition

We generate collaboration revenue primarily from research and collaboration and license agreements with customers. Goods and services in the agreements
may  include  the  grant  of  licenses  for  the  use  of  our  technology,  the  provision  of  services  associated  with  the  research  and  development  of  product
candidates, manufacturing services, and participation in joint steering committees. The terms of these arrangements typically include payment to us of one
or more of the following: non-refundable, up-front license fees; research, development, regulatory and commercial milestone payments; reimbursement of
research and development services; option payments; reimbursement of certain costs; payments for manufacturing supply services; and future royalties on
net sales of licensed products.

When two or more contracts are entered into with the same customer at or near the same time, we evaluate the contracts to determine whether the contracts
should be accounted for as a single arrangement. Contracts are combined and accounted for as a single arrangement if one or more of the following criteria
are met: (i) the contracts are negotiated as a package with a single commercial objective; (ii) the amount of consideration to be paid in one contract depends
on the price or performance of the other contract; or (iii) the goods or services promised in the contracts (or some goods or services promised in each of the
contracts) are a single performance obligation.

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In determining the appropriate amount of revenue to be recognized as we fulfill our obligations under each of our agreements, management performs the
following  steps:  (i)  identification  of  the  promised  goods  or  services  in  the  contract;  (ii)  determination  of  whether  the  promised  goods  or  services  are
performance  obligations  including  whether  they  are  distinct  in  the  context  of  the  contract;  (iii)  measurement  of  the  transaction  price,  including  any
constraints on variable consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when (or as) we
satisfy each performance obligation. As part of the accounting for contracts with customers, we develop assumptions that require judgment to determine
whether promised goods and services represent distinct performance obligations and the standalone selling price for each performance obligation identified
in  the  contract.  This  evaluation  is  subjective  and  requires  us  to  make  judgments  about  the  promised  goods  and  services  and  whether  those  goods  and
services are separable from other aspects of the contract. Further, determining the standalone selling price for performance obligations requires significant
judgment, and when an observable price of a promised good or service is not readily available, we consider relevant assumptions to estimate the standalone
selling price, including, as applicable, market conditions, development timelines, probabilities of technical and regulatory success, reimbursement rates for
personnel costs, forecasted revenues, potential limitations to the selling price of the product and discount rates.

We apply judgment in determining whether a combined performance obligation is satisfied at a point in time or over time, and, if over time, concluding
upon the appropriate method of measuring progress to be applied for purposes of recognizing revenue. We evaluate the measure of progress each reporting
period and, as estimates related to the measure of progress change, related revenue recognition is adjusted accordingly. Changes in our estimated measure
of  progress  are  accounted  for  prospectively  as  a  change  in  accounting  estimate.  We  recognize  collaboration  revenue  by  measuring  the  progress  toward
complete satisfaction of the performance obligation using an input measure. In order to recognize revenue over the research and development period, we
measure actual costs incurred to date compared to the overall total expected costs to satisfy the performance obligation. Revenues are recognized as the
program  costs  are  incurred.  We  will  re-evaluate  the  estimate  of  expected  costs  to  satisfy  the  performance  obligation  each  reporting  period  and  make
adjustments  for  any  significant  changes.  Amounts  received  prior  to  satisfying  the  revenue  recognition  criteria  are  recorded  as  contract  liabilities  in  our
balance sheets. If the related performance obligation is expected to be satisfied within the next twelve months, this will be classified in current liabilities.
Amounts recognized as revenue prior to receipt are recorded as contract assets in our balance sheets. If we expect to have an unconditional right to receive
the consideration in the next twelve months, this will be classified in current assets. A net contract asset or liability is presented for each contract with a
customer.

Milestone  Payments:  At  the  inception  of  each  arrangement  that  includes  research  and  development  milestone  payments,  we  evaluate  whether  the
milestones are considered probable of being reached and estimate the amount to be included in the transaction price using the most likely amount method.
Amounts  of  variable  consideration  are  included  in  the  transaction  price  to  the  extent  that  it  is  probable  that  a  significant  reversal  in  the  amount  of
cumulative  revenue  recognized  will  not  occur  and  when  the  uncertainty  associated  with  the  variable  consideration  is  subsequently  resolved.  Milestone
payments  that  are  not  within  the  control  of  us  or  the  licensee,  such  as  regulatory  approvals,  are  not  considered  probable  of  being  achieved  until  those
approvals are received. The transaction price is then allocated to each performance obligation on a relative standalone selling price basis, for which we
recognize revenue as or when the performance obligations under the contract are satisfied. At the end of each subsequent reporting period, we re-evaluate
the probability of achievement of such development milestones and any related constraints, and if necessary, adjust our estimate of the overall transaction
price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect earnings in the period of adjustment.

Manufacturing  supply  services:  Arrangements  that  include  a  promise  for  the  future  supply  of  drug  substance  or  drug  product  for  either  clinical
development or commercial supply at the customer’s discretion are generally considered as options. We assess if these options provide a material right to
the licensee and if so, they are accounted for as separate performance obligations. If we are entitled to additional payments when the customer exercises
these options, any payments are recorded in product supply revenue when the customer obtains control of the goods, which is upon delivery.

Royalties: For arrangements that include sales-based royalties, including milestone payments based on the level of sales, and where the license is deemed to
be the predominant item to which the royalties relate, we recognize revenue at the later of (i) when the related sales occur, or (ii) when the performance
obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). To date, royalty revenue resulting from licensing
arrangements has not been material.

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Licenses of intellectual property: If a license granted to a customer to use our intellectual property is determined to be distinct from the other performance
obligations identified in the arrangement, we recognize revenue from consideration allocated to the license when the license is transferred to the licensee
and the licensee is able to use and benefit from the license. For licenses that are bundled with other promises, we apply judgment to assess the nature of the
combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, to
conclude upon the appropriate method of measuring progress for purposes of recognizing revenue related to consideration allocated to the performance
obligation.

Options: Customer options, such as options granted to allow a licensee to choose to research, develop and commercialize licensed compounds are evaluated
at contract inception in order to determine whether those options provide a material right (i. e., an optional good or service offered for free or at a discount)
to the customer. If the customer options represent a material right, the material right is treated as a separate performance obligation at the outset of the
arrangement. We allocate the transaction price to material rights based on the standalone selling price, and revenue is recognized when or as the future
goods  or  services  are  transferred  or  when  the  option  expires.  Customer  options  that  are  not  material  rights  do  not  give  rise  to  a  separate  performance
obligation, and as such, the additional consideration that would result from a customer exercising an option in the future is not included in the transaction
price for the current contract. Instead, the option is deemed a marketing offer, and additional option fee payments are recognized or being recognized as
revenue  when  the  licensee  exercises  the  option.  The  exercise  of  an  option  that  does  not  represent  a  material  right  is  treated  as  a  separate  contract  for
accounting purposes.

Contract modifications:  Contract  modifications,  defined  as  changes  in  the  scope  or  price  (or  both)  of  a  contract  that  are  approved  by  the  parties  to  the
contract, such as a contract amendment, exist when the parties to a contract approve a modification that either creates new or changes existing enforceable
rights and obligations of the parties to the contract. Depending on facts and circumstances, we account for a contract modification as one of the following:
(i) a separate contract; (ii) a termination of the existing contract and a creation of a new contract; or (iii) a combination of the preceding treatments. A
contract modification is accounted for as a separate contract if the scope of the contract increases because of the addition of promised goods or services that
are distinct and the price of the contract increases by an amount of consideration that reflects our standalone selling prices of the additional promised goods
or services. When a contract modification is not considered a separate contract and the remaining goods or services are distinct from the goods or services
transferred  on  or  before  the  date  of  the  contract  modification,  we  account  for  the  contract  modification  as  a  termination  of  the  existing  contract  and  a
creation of a new contract. When a contract modification is not considered a separate contract and the remaining goods or services are not distinct, we
account for the contract modification as an add-on to the existing contract and as an adjustment to revenue on a cumulative catch-up basis.

We receive payments from our licensees as established in each contract. Upfront payments and fees are recorded as deferred revenue upon receipt or when
due  and  may  require  deferral  of  revenue  recognition  to  a  future  period  until  we  perform  our  obligations  under  these  arrangements.  Where  applicable,
amounts  are  recorded  as  unbilled  revenue  when  our  right  to  consideration  is  unconditional.  We  do  not  assess  whether  a  contract  with  a  customer  has  a
significant financing component if the expectation at contract inception is such that the period between payment by the licensees and the transfer of the
promised goods or services to the licensees will be one year or less.

Cost of Goods Sold

Cost of product sales consists of the cost of commercial goods sold to our Customers. Other cost of revenue consists of the cost of materials sold to our
international  partners  under  product  supply  agreements,  as  well  as  payments  due  to  AstraZeneca  AB  (AstraZeneca)  based  on  sales  of  tenapanor.  We
capitalize  inventory  costs  associated  with  the  production  of  our  products  after  regulatory  approval  or  when,  based  on  management’s  judgment,  future
commercialization is considered probable and the future economic benefit is expected to be realized. Otherwise, such costs are expensed as research and
development. A portion of the costs of IBSRELA and XPHOZAH units recognized as revenue during the years ended December 31, 2023 and 2022 were
expensed  in  periods  prior  to  the  commencement  of  capitalization  of  inventory  costs  for  each  respective  product.  As  of  December  31,  2023  and
December 31, 2022, we had approximately $21.8 million and $28.0 million, respectively, of inventory on hand that was previously expensed as research
and  development  expense  and  will  not  be  reported  as  cost  of  goods  sold  in  future  periods  when  sales  of  IBSRELA  and  XPHOZAH  are  recognized  as
revenue.

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Other  cost  of  revenue  includes  payments  due  to  AstraZeneca,  which  under  the  terms  of  a  termination  agreement  entered  into  in  2015  (AstraZeneca
Termination Agreement) is entitled to (i) future royalties at a rate of 10% of net sales of tenapanor or other NHE3 products by us or our licensees, and (ii)
20%  of  non-royalty  revenue  received  from  our  collaboration  partners  in  connection  with  the  development  and  commercialization  of  tenapanor  or  other
NHE3 products. We have agreed to pay AstraZeneca up to a maximum of $75.0 million in the aggregate for (i) and (ii). We recognize these expenses as
other  cost  of  revenue  when  we  recognize  the  corresponding  revenue  that  gives  rise  to  payments  due  to  AstraZeneca.  To  date,  we  have  recognized  an
aggregate  of  $27.6  million  as  other  cost  of  revenue  under  the  AstraZeneca  Termination  Agreement.  See  details  in  Note  7,  Collaboration  and  Licensing
Agreements, under AstraZeneca, in the notes to our financial statement of this Annual Report on Form 10-K.

Research and Development Costs

Research and development costs are charged to expense as incurred and consisted of costs incurred to further our research and development activities and
include salaries and related employee benefits, costs associated with clinical trials, costs related to pre-commercialization manufacturing activities such as
manufacturing  process  validation  activities  and  the  manufacturing  of  clinical  drug  supply,  nonclinical  research  and  development  activities,  regulatory
activities,  research-related  overhead  expenses  and  fees  paid  to  external  service  providers  and  contract  research  and  manufacturing  organizations  that
conduct certain research and development activities on our behalf.

Accrued Expenses

As  part  of  the  process  of  preparing  our  financial  statements,  we  are  required  to  estimate  our  accrued  expenses.  This  process  involves  reviewing  open
contracts and purchase orders, communicating with our personnel to identify services that have been performed on our behalf and estimating the level of
service performed and the associated cost incurred for the service when we have not yet been invoiced or otherwise notified of the actual cost. The majority
of our service providers invoice us monthly in arrears for services performed or when contractual milestones are met. We make estimates of our accrued
expenses as of each balance sheet date in our financial statements based on facts and circumstances known to us at that time. We periodically confirm the
accuracy of our estimates with our service providers and make adjustments if necessary.

In  accruing  service  fees,  we  estimate  the  time  period  over  which  each  component  of  a  service  will  be  performed,  and  estimate,  with  vendor  input  if
appropriate. If the actual timing of the performance of services or the level of effort varies from our estimate, we adjust the accrued or prepaid expense
balance accordingly. Although we do not expect our estimates to be materially different from amounts actually incurred, if our estimates of the status and
timing of services performed differ from the actual status and timing of services performed, we may report amounts that are too high or too low in any
particular period.

Stock-Based Compensation

We recognize compensation expense for all stock-based payment awards made to employees, non-employees and directors based on estimated fair values.
For employee and non-employee stock options, we determine the grant date fair value of the awards using the Black-Scholes option-pricing model and
generally  recognize  the  fair  value  as  stock-based  compensation  expense  on  a  straight-line  basis  over  the  vesting  period  of  the  respective  awards.  For
restricted stock and performance-based restricted stock, to the extent they are probable, the compensation cost for these awards is based on the closing price
of our common stock on the date of grant and recognized as compensation expense on a straight-line basis over the requisite service period. Stock-based
compensation expense is based on the value of the portion of stock-based payment awards that is ultimately expected to vest. As such, our stock-based
compensation is reduced for the estimated forfeitures at the date of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from
those estimates.

Derivatives and Hedging Activities

We account for our derivative instruments as either assets or liabilities on the balance sheet and measure them at fair value. Derivatives are adjusted to fair
value through other income (expense), net in the statements of operations and comprehensive loss.

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Non-cash Interest Expense on Deferred Royalty Obligation

Non-cash interest expense related to the sale of future royalties represents the imputed interest expense on our deferred royalty obligation related to the sale
of future royalties using the effective interest method. As further described in Note 8. Deferred Royalty Obligation Related to the Sale of Future Royalties,
in  June  2022,  we  and  HealthCare  Royalty  Partners  IV,  L.P.  (HCR)  entered  into  a  Royalty  and  Sales  Milestone  Interest  Acquisition  Agreement  (HCR
Agreement). Under the terms of the HCR Agreement, HCR agreed to pay us up to $20.0 million in exchange for the royalty payments and commercial
milestone payments (collectively the Royalty Interest Payments) that we may receive under our 2017 License Agreement with Kyowa Kirin, as amended,
based upon Kyowa Kirin's net sales of tenapanor in Japan for hyperphosphatemia. As part of the HCR Agreement, we received a $10.0 million upfront
payment from HCR in June 2022 and recorded it as a deferred royalty obligation on our balance sheet. In September 2023, we announced that Kyowa Kirin
received approval from the Japanese MHLW for the New Drug Application for tenapanor for the improvement of hyperphosphatemia in adult patients with
chronic kidney disease on dialysis, which entitled us to a $5.0 million payment under the terms of the HCR Agreement, which we received in October
2023. Non-cash interest expense will be recognized over the life of the HCR Agreement using the effective interest method based on the imputed interest
rate derived from estimated amounts and timing of future royalty payments to be received from Kyowa Kirin.

Leases

We  determine  if  an  arrangement  is  a  lease  at  the  inception  of  the  arrangement.  Operating  leases  are  included  in  right-of-use  assets,  current  portion  of
operating  lease  liability,  and  operating  lease  liability,  net  of  current  portion  in  our  balance  sheets.  Right-of-use  assets  represent  our  right  to  use  an
underlying asset for the lease term and lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease right-of-use
assets and liabilities are recognized at the lease commencement date based on the present value of lease payments over the lease term. In determining the
present value of lease payments, we use our incremental borrowing rate based on the information available at the lease commencement date. The operating
lease right-of-use assets also include any lease payments made and exclude lease incentives. Our lease terms may include options to extend or terminate the
lease when it is reasonably certain that we will exercise any such options. Lease expense is recognized on a straight-line basis over the expected lease term.
We have elected not to separate lease and non-lease components, such as common area maintenance charges, and instead it accounts for these as a single
lease component.

Net Loss per Share

Basic net loss per common share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding during the
period, without consideration of potential shares of common stock. Diluted net loss per common share in the periods presented is the same as basic net loss
per common share, since the effects of potentially dilutive securities are antidilutive due to the net loss for all periods presented.

Recent Accounting Pronouncements

New Accounting Pronouncements - Recently Adopted

In  July  2023,  the  Financial  Accounting  Standards  Board  (FASB)  issued  Accounting  Standards  Update  (ASU)  No.  2023-03,  Presentation  of  Financial
Statements  (Topic  205),  Income  Statement  -  Reporting  Comprehensive  Income  (Topic  220),  Distinguishing  Liabilities  from  Equity  (Topic  480),  Equity
(Topic 505), and Compensation - Stock Compensation (Topic 718) Presentation of Financial Statements (ASU 2023-03). ASU 2023-03 amends the FASB
Accounting  Standards  Codification  to  include  Amendments  to  SEC  Paragraphs  pursuant  to  SEC  Staff  Accounting  Bulletin  No.  120,  SEC  Staff
Announcement at the March 24, 2022 EITF Meeting, and SEC Staff Accounting Bulletin Topic 6.B, Accounting Series Release 280 - General Revision of
Regulation S-X: Income or Loss Applicable to Common Stock. As the ASU does not provide any new guidance, there is no transition or effective date
associated with its adoption. Accordingly, we adopted ASU 2023-03 immediately upon its issuance. The adoption of ASU 2023-03 did not have any impact
on our financial statement presentation or related disclosures.

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Recent Accounting Pronouncements Not Yet Adopted

In October 2023, the FASB issued ASU No. 2023-06, Disclosure Improvements - Codification Amendments in Response to the SEC’s Disclosure Update
and Simplification Initiative. The amendments in this Update modify the disclosure or presentation requirements of a variety of Topics in the Codification.
The amendments are in response to the U.S. Securities and Exchange Commission's (SEC) Release No. 33-10532, Disclosure Update and Simplification, in
which  the  SEC  referred  certain  of  its  disclosure  requirements  that  overlap  with,  but  require  incremental  information  to,  generally  accepted  accounting
principles to the FASB for potential incorporation into the Codification. For entities subject to the SEC’s existing disclosure requirements and for entities
required to file or furnish financial statements with or to the SEC in preparation for the sale of or for purposes of issuing securities that are not subject to
contractual  restrictions  on  transfer,  the  effective  date  for  each  amendment  will  be  the  date  on  which  the  SEC’s  removal  of  that  related  disclosure  from
Regulation S-X or Regulation S-K becomes effective, with early adoption prohibited. For all other entities, the amendments will be effective two years
later.  For  all  entities,  if  by  June  30,  2027,  the  SEC  has  not  removed  the  applicable  requirement  from  Regulation  S-X  or  Regulation  S-K,  the  pending
content of the related amendment will be removed from the Codification and will not become effective for any entity. Management is currently assessing
the impact of this standard on the Company’s financial statements.

In  November  2023,  the  FASB  issued  ASU  No.  2023-07,  Segment  Reporting  (Topic  280)  -  Improvements  to  Reportable  Segment  Disclosures.  The
amendments  in  this  Update  improve  reportable  segment  disclosure  requirements,  primarily  through  enhanced  disclosures  about  significant  segment
expenses. The amendments in this update improve financial reporting by requiring disclosure of incremental segment information on an annual and interim
basis for all public entities to enable investors to develop more decision-useful financial analyses. The amendments in this update are effective for fiscal
years  beginning  after  December  15,  2023,  and  interim  periods  within  fiscal  years  beginning  after  December  15,  2024.  Early  adoption  is  permitted.
Management is currently assessing the impact of this standard on the Company’s financial statements.

In  December  2023,  the  FASB  issued  ASU  No.  2023-09,  Income  Taxes  (Topic  740)  -  Improvements  to  Income  Tax  Disclosures,  an  amendment  which
modifies the measurement and recognition of credit losses for most financial assets and certain other instruments. The amendments in this Update provide
more transparency about income tax information through improvements to income tax disclosures primarily related to the rate reconciliation and income
taxes paid information. For public business entities, the amendments in this Update are effective for annual periods beginning after December 15, 2024.
Early adoption is permitted on a prospective basis for annual financial statements that have not yet been issued or made available for issuance. Management
is currently assessing the impact of this standard on the Company’s financial statements.

There were various other accounting standards and interpretations issued recently, none of which are expected to have a material impact on our financial
position, operations or cash flows.

3.     CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS

Securities classified as cash, cash equivalents and short-term investments as of December 31, 2023 and 2022 are summarized below (in thousands):

December 31, 2023
Gross Unrealized

Amortized Cost

Gains

Losses

Fair Value

Cash and cash equivalents:

Cash
Money market funds

Total cash and cash equivalents
Short-term investments:

U.S. government-sponsored agency bonds
Commercial paper
Asset-backed securities
U.S. treasury securities
Total short-term investments

Total cash, cash equivalents and investments

2,829  $

18,641 
21,470 

101,892  $
49,630  $
8,628 
2,455 
162,605 
184,075  $

—  $
— 
— 

235  $
41  $
2 
2 
280 
280  $

—  $
— 
— 

(34) $
(17) $
(5)
— 
(56)
(56) $

2,829 
18,641 
21,470 

102,093 
49,654 
8,625 
2,457 
162,829 
184,299 

$

$
$

$

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Cash and cash equivalents:

Cash
Money market funds

Total cash and cash equivalents
Short-term investments
Commercial paper
Corporate bonds
U.S. government-sponsored agency bonds

Total short-term investments

Total cash, cash equivalents and investments

December 31, 2022
Gross Unrealized

Amortized Cost

Gains

Losses

Fair Value

$

$

$

11,827  $
84,313 
96,140 

25,336  $
1,000 
1,487 
27,823 
123,963  $

—  $
— 
— 

6  $

— 
— 
6 
6  $

—  $
— 
— 

(51) $
(1)
(8)
(60)
(60) $

11,827 
84,313 
96,140 

25,291 
999 
1,479 
27,769 
123,909 

Cash  equivalents  consist  of  money  market  funds  with  original  maturities  of  three  months  or  less  at  the  time  of  purchase,  and  the  carrying  amount  is  a
reasonable approximation of fair value. We invest our cash in high quality securities of financial and commercial institutions. These securities are carried at
fair value, which is based on readily available market information, with unrealized gains and losses included in accumulated other comprehensive income
(loss) within stockholders’ equity on our balance sheets. We use the specific identification method to determine the amount of realized gains or losses on
sales of marketable securities. Realized gains or losses have been insignificant and are included in other income, net, in the statement of operations and
comprehensive loss.

All of the short-term available-for sale securities held as of December 31, 2023 and 2022 had contractual maturities of less than one year. Our available-for-
sale securities are subject to a periodic impairment review. We consider a debt security to be impaired when its fair value is less than its carrying cost, in
which case we would further review the investment to determine whether it is other-than-temporarily impaired. When we evaluate an investment for other-
than-temporary impairment, we review factors such as the length of time and extent to which fair value has been below cost basis, the financial condition of
the issuer and any changes thereto, intent to sell, and whether it is more likely than not we will be required to sell the investment before the recovery of its
cost  basis.  If  an  investment  is  other-than-temporarily  impaired  or  subject  to  credit  losses,  we  write  it  down  through  the  statement  of  operations  and
comprehensive loss to its fair value and establish that value as a new cost basis for the investment. Our unrealized losses as of December 31, 2023 and 2022
were not material. We determined that none of our available-for-sale securities were other-than-temporarily impaired as of December 31, 2023 and 2022,
and  no  investment  was  in  a  continuous  unrealized  loss  position  for  more  than  one  year.  As  such,  we  believe  that  it  is  more  likely  than  not  that  the
investments will be held until maturity or a forecasted recovery of fair value.

Based  on  our  procedures  under  the  expected  credit  loss  model,  including  an  assessment  of  unrealized  losses  in  our  portfolio,  we  concluded  that  any
unrealized losses on our marketable securities were not attributable to credit and, therefore, we have not recorded an allowance for credit losses for these
securities as of December 31, 2023 and 2022.

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4.     FAIR VALUE MEASUREMENTS

Fair  value  is  defined  as  the  exchange  price  that  would  be  received  for  an  asset  or  paid  to  transfer  a  liability  (an  exit  price)  in  the  principal  or  most
advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to
measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs.

The three-level hierarchy for the inputs to valuation techniques is briefly summarized as follows:

Level 1   – Valuations are based on quoted prices in active markets for identical assets or liabilities and readily accessible to us at the reporting
date.

Level 2   –  Valuations based on inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets
or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for
substantially the full term of the assets or liabilities.

Level 3  –  Valuations based on unobservable inputs for which there is little or no market data, which require us to develop our own assumptions.

The following table sets forth the fair value of our financial assets and liabilities that are measured or disclosed on a recurring basis by level within the fair
value hierarchy (in thousands):

Assets:

Money market funds
U.S. government-sponsored agency bonds
Commercial paper
Asset-backed securities
U.S. treasury securities

Total

Liabilities:

Derivative liabilities for exit fee

Total

Assets:

Money market funds
Commercial paper
U.S. government-sponsored agency bonds
Corporate bonds

Total

Liabilities:

Derivative liability for exit fees

Total

Total Fair Value

Level 1

Level 2

Level 3

December 31, 2023

18,641  $
102,093 
49,654 
8,625 
2,457 
181,470  $

18,641  $
— 
— 
— 
— 
18,641  $

—  $

102,093 
49,654 
8,625 
2,457 
162,829  $

675  $
675  $

—  $
—  $

—  $
—  $

Total
Fair Value

Level 1

Level 2

Level 3

December 31, 2022

84,313  $
25,291 
1,479 
999 
112,082  $

84,313  $
— 
— 
— 
84,313  $

—  $

25,291 
1,479 
999 
27,769  $

— 
— 
— 
— 
— 
— 

675 
675 

— 
— 
— 
— 
— 

1,656  $
1,656  $

—  $
—  $

—  $
—  $

1,656 
1,656 

$

$

$
$

$

$

$
$

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Where  quoted  prices  are  available  in  an  active  market,  securities  are  classified  as  Level  1.  We  classify  money  market  funds  as  Level  1.  When  quoted
market prices are not available for the specific security, we estimate fair value by using benchmark yields, reported trades, broker/dealer quotes and issuer
spreads. We classify U.S. government-sponsored agency bonds, U.S. treasury securities, corporate bonds, commercial paper, and asset-backed securities as
Level 2. In certain cases, where there is limited activity or less transparency around inputs to valuation, securities or derivative liabilities, such as the 2018
Exit Fee and 2022 Exit Fee, as defined and discussed in Note 10. Derivative Liabilities, are classified as Level 3.

The carrying amounts reflected in the balance sheets for cash equivalents, short-term investments, accounts receivable, prepaid expenses and other current
assets, accounts payable and accrued expenses approximate their fair values at both December 31, 2023 and 2022, due to their short-term nature.

Based  on  our  procedures  under  the  expected  credit  loss  model,  including  an  assessment  of  unrealized  losses  in  our  portfolio,  we  concluded  that  any
unrealized losses on our marketable securities were not attributable to credit and, therefore, we have not recorded an allowance for credit losses for these
securities as of December 31, 2023 and 2022.

Fair Value of Debt

The principal amount outstanding under our term loan facilities is subject to a variable interest rate. Therefore, we believe the carrying amount of the term
loan facility approximates fair value as of December 31, 2023 and 2022. See Note 9. Borrowings for a description of the Level 2 inputs used to estimate the
fair value of the liability.

The carrying value of the deferred royalty obligation related to the sale of future royalties approximates its fair value as of December 31, 2023 and is based
on our current estimates of future royalties and commercialization milestones expected to be paid to us by Kyowa Kirin Co., Ltd. (KKC) over the life of the
agreement. See Note 8. Deferred Royalty Obligation Related to the Sale of Future Royalties for a description of the Level 3 inputs used to estimate the fair
value of the liability.

5. INVENTORY

Inventory as of December 31, 2023 and 2022 consisted of the following (in thousands):

Raw materials
Work in process
Finished goods

Total
Reported as:
Inventory
Inventory, non-current

Total

December 31, 2023

December 31, 2022

$

$

$

$

22,920  $
24,582 
1,985 
49,487  $

12,448  $
37,039 
49,487  $

22,299 
5,324 
723 
28,346 

3,282 
25,064 
28,346 

In addition to inventory, we had prepaid commercial manufacturing of $23.2 million and $13.6 million as of December 31, 2023 and 2022, respectively,
which consisted of prepayments to third party contract manufacturing organizations, including prepayments of $4.2 million and zero as of December 31,
2023 and 2022, respectively, that are expected to be converted into inventory after 12 months.

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6. REVENUE

Total revenues during the years ended December 31, 2023, 2022, and 2021 were as follows (in thousands):

Product sales, net:

IBSRELA
XPHOZAH

Total product sales, net
Licensing revenue
Product supply revenue
Collaborative development revenue

Total revenues

Year Ended December 31,

2023

2022

2021

$

$

80,062  $
2,464 
82,526 
35,809 
6,121 
— 
124,456  $

15,600  $
— 
15,600 
35,031 
1,527 
— 
52,158  $

— 
— 
— 
5,013 
907 
4,177 
10,097 

Revenue from the following Customers who contributed greater than 10% of our gross product revenue during the years ended December 31, 2023 and
2022 as a percentage of total gross product revenue was as follows:

BioRidge Pharma, LLC
Cardinal Health
AmerisourceBergen Drug Corporation
McKesson Corporation

Year Ended December 31,
2022
2023

26.3 %
21.6 %
20.9 %
17.2 %

— %
23.1 %
26.8 %
21.6 %

The  activities  and  ending  reserve  balances  for  each  significant  category  of  discounts  and  allowances,  which  constitute  variable  consideration,  were  as
follows (in thousands):

Balance as of December 31, 2021

Provisions
Credits/payments

Balance as of December 31, 2022

Provisions
Credits/payments

Balance as of December 31, 2023

Discounts and
Chargebacks

Rebates,
Wholesaler and
GPO Fees

Copay and
Returns

Total

$

$

—  $
825 
(683)
142 
5,341 
(5,005)

478  $

—  $

2,721 
(1,277)
1,444 
15,365 
(12,575)

4,234  $

—  $

2,502 
(1,244)
1,258 
10,629 
(7,971)
3,916  $

— 
6,048 
(3,204)
2,844 
31,335 
(25,551)
8,628 

Adjustments to prior period provisions recorded in the current period were not material.

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7.     COLLABORATION AND LICENSING AGREEMENTS

Kyowa Kirin Co., Ltd. (Kyowa Kirin)

In November 2017, we entered into an exclusive license agreement with Kyowa Kirin (2017 Kyowa Kirin Agreement), under which we granted Kyowa
Kirin an exclusive license to develop and commercialize certain NHE3 inhibitors including tenapanor in Japan for the treatment of cardiorenal diseases and
conditions, excluding cancer. We retained the rights to tenapanor outside of Japan, and also retained the rights to tenapanor in Japan for indications other
than those stated above. Pursuant to the 2017 Kyowa Kirin Agreement, Kyowa Kirin is responsible for all costs and expenses incurred in the development
and commercialization of tenapanor for all licensed indications in Japan. We are responsible for supplying the tenapanor drug substance for Kyowa Kirin’s
use in development and commercialization throughout the term of the 2017 Kyowa Kirin Agreement, provided that Kyowa Kirin may exercise an option to
manufacture the tenapanor drug substance under certain conditions. In October 2022, we entered into a Commercial Supply Agreement with Kyowa Kirin
to further define the obligations of the parties with respect to the commercial supply of tenapanor drug substance (2022 Kyowa Kirin Supply Agreement).
As detailed below under the heading Deferred Revenue we have received advanced payments from Kyowa Kirin for the manufacturing of tenapanor drug
substance that will be used to satisfy Kyowa Kirin needs.

We assessed these arrangements in accordance with Accounting Standards Update (ASU) No. 2014-09, Revenue from Contracts with Customers  (Topic
606) and related amendments (ASC 606) and concluded that the contract counterparty, Kyowa Kirin, is a customer. Under the terms of the 2017 Kyowa
Kirin Agreement, we received $30.0 million in upfront license fees, which was recognized as revenue when the agreement was executed. Based on our
assessment, management determined that the license and the manufacturing supply services were its material performance obligations at the inception of
the 2017 Kyowa Kirin Agreement, and as such, each of the performance obligations is distinct.

We may be entitled to receive up to $55.0 million in total development and regulatory milestones, of which $35.0 million has been received and recognized
as revenue as of December 31, 2023. We may also be eligible to receive approximately ¥8.5 billion for commercialization milestones, or approximately
$60.3 million at the currency exchange rate on December 31, 2023, as well as reimbursement of costs plus a reasonable overhead for the supply of product
and  royalties  on  net  sales  throughout  the  term  of  the  agreement.  As  discussed  in  Note  8.  Deferred  Royalty  Obligation  Related  to  the  Sale  of  Future
Royalties, the future royalties and commercial milestone payments we may receive under the 2017 Kyowa Kirin Agreement will be remitted to HealthCare
Royalty Partners IV, L.P. pursuant to a Royalty and Sales Milestone Interest Acquisition Agreement. The variable consideration related to the remaining
milestone payments was fully constrained at December 31, 2023.

In April 2022, we entered into a second amendment to the 2017 Kyowa Kirin Agreement (2022 Amendment). Under the terms of the 2022 Amendment, we
and Kyowa Kirin agreed to a reduction in the royalty rate payable to us by Kyowa Kirin upon net sales of tenapanor for hyperphosphatemia in Japan. The
royalty rate will be reduced from the high teens to low double digits for a two-year period of time following the first commercial sale in Japan, and then to
mid-single digits for the remainder of the royalty term. As discussed in Note 8. Deferred Royalty Obligation Related to the Sale of Future Royalties, the
future commercial milestones and royalties we may receive under the 2017 Kyowa Kirin Agreement will be remitted to HealthCare Royalty Partners IV,
L.P. pursuant to a Royalty and Sales Milestone Interest Acquisition Agreement. As consideration for the reduction in the royalty rate, Kyowa Kirin agreed
to pay us up to an additional $40.0 million payable in two tranches, with the first payment due following Kyowa Kirin's filing with the Japanese Ministry of
Health, Labour and Welfare (MHLW) of its application for marketing approval for tenapanor and the second payment due following Kyowa Kirin’s receipt
of regulatory approval to market tenapanor for hyperphosphatemia in Japan, both of which occurred as of September 30, 2023.

In October 2022, we announced that Kyowa Kirin submitted a New Drug Application (NDA) to the Japanese MHLW for tenapanor for the improvement of
hyperphosphatemia  in  adult  patients  with  CKD  on  dialysis,  which  resulted  in  payment  to  us  from  Kyowa  Kirin  for  an  aggregate  of  $35.0  million  for
milestone  payments  and  payments  under  the  2022  Amendment.  We  received  these  payments  during  the  fourth  quarter  of  2022  and  recorded  them  as
licensing revenue on our statement of operations and comprehensive income (loss).

In  September  2023,  we  announced  that  Kyowa  Kirin  received  approval  from  the  Japanese  MHLW  for  the  NDA  for  tenapanor  for  the  improvement  of
hyperphosphatemia  in  adult  patients  with  CKD  on  dialysis,  which  resulted  in  payment  to  us  from  Kyowa  Kirin  for  an  aggregate  of  $30.0  million  for
milestone payments and payments under the 2022 Amendment. We received these payments in October 2023 and recorded them as licensing revenue on
our statement of operations and comprehensive income (loss) when earned during the three months ended September 30, 2023.

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During the years ended December 31, 2023, 2022, and 2021, we recognized $30.0 million, $35.0 million, and $5.0 million of licensing revenue pursuant to
the 2017 Kyowa Kirin Agreement, as amended.

During the years ended December 31, 2023, 2022, and 2021, we recognized $6.1 million, $1.5 million, and $0.9 million respectively, of product supply
revenue pursuant to the 2017 Kyowa Kirin Agreement.

Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. (Fosun Pharma)

In December 2017, we entered into an exclusive license agreement with Fosun Pharma (Fosun Agreement) for the development, commercialization and
distribution of tenapanor in China for both hyperphosphatemia and IBS-C. We assessed these arrangements in accordance with ASC 606 and concluded
that the contract counterparty, Fosun Pharma, is a customer. Under the terms of the Fosun Agreement, we received $12.0 million in upfront license fees
which  was  recognized  as  revenue  when  the  agreement  was  executed.  Based  on  our  assessment,  we  determined  that  the  license  and  the  manufacturing
supply services represented the material performance obligations at the inception of the agreement and, as such, each of the performance obligations are
distinct.

We  may  be  entitled  to  receive  development  and  commercialization  milestones  of  up  to $113.0  million,  of  which  $8.0  million  has  been  recognized  as
revenue and $5.0 million has been received as of December 31, 2023 and $3.0 million was received in January 2024, as well as reimbursement of cost plus
a reasonable overhead for the supply of product and tiered royalties on net sales ranging from the mid-teens to 20%. The variable consideration related to
the remaining development milestone payments was fully constrained at December 31, 2023.

In  July  2023,  we  announced  that  an  NDA  for  tenapanor  had  been  accepted  for  review  by  China’s  Center  for  Drug  Evaluation  of  the  National  Medical
Products  Administration  (NMPA)  for  the  control  of  serum  phosphorus  in  adult  patients  with  CKD  on  hemodialysis.  This  acceptance  triggered  a  $2.0
million milestone payment to us under the terms of the Fosun Agreement. We received this payment during the third quarter of 2023 and recorded it as
licensing  revenue  on  our  statement  of  operations  and  comprehensive  loss  when  earned  during  the  three  months  ended  September  30,  2023.  In  October
2023, we announced that the U.S. FDA has approved XPHOZAH to reduce serum phosphorus in adults with CKD on dialysis as add-on therapy in patients
who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy. This triggered an additional $3.0
million milestone payment to us under the terms of the Fosun Agreement, which was received during the first quarter of 2024. Also, in October 2023, we
announced that Fosun Pharma received approval from the Hong Kong Department of Health for the marketing application for tenapanor for the treatment
of irritable bowel syndrome with constipation (IBS-C).

During the year ended December 31, 2023, we recognized $5.0 million of licensing revenue pursuant to the Fosun Agreement. During the years ended
December 31, 2022, and 2021, we did not recognize a material amount of revenue pursuant to the Fosun Agreement.

Knight Therapeutics, Inc. (Knight)  

In  March  2018,  we  entered  into  an  exclusive  license  agreement  with  Knight  Therapeutics,  Inc.,  (Knight  Agreement)  for  the  development,
commercialization and distribution of tenapanor in Canada for hyperphosphatemia and IBS-C. We assessed this arrangement in accordance with ASC 606
and concluded that the contract counterparty, Knight, is a customer. Based on our assessment, we determined that the license and the manufacturing supply
services were the material performance obligations at the inception of the agreement and, as such, each of the performance obligations are distinct.

Under the terms of the Knight Agreement, we received a $2.3 million non-refundable, one-time upfront payment in March 2018 and may be eligible to
receive additional development and commercialization milestone payments worth up to CAD 22.2 million, or approximately $16.7 million at the currency
exchange rate on December 31, 2023, of which $0.7 million has been received and recognized as revenue as of December 31, 2023. We are also eligible to
receive  royalties  ranging  from  the  mid-single  digits  to  the  low  twenties  throughout  the  term  of  the  agreement,  and  a  transfer  price  for  manufacturing
services. The variable consideration related to the remaining development milestone payments was fully constrained at December 31, 2023.

During the years ended December 31, 2023, 2022, and 2021, we did not recognize a material amount of revenue pursuant to the Knight Agreement.

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METiS Therapeutics Inc. (METiS) 

In April 2023, we entered into an exclusive, worldwide license agreement with METiS Therapeutics Inc., (METiS Agreement) for the development and
commercialization of a portfolio of TGR5 agonist compounds that were discovered and developed by Ardelyx for all therapeutic areas. We assessed this
arrangement in accordance with ASC 606 and concluded that the contract counterparty, METiS, is a customer. Based on our assessment, we determined
that the license was the material performance obligation at the inception of the agreement.

Under the terms of the METiS Agreement, we received a $0.8  million  non-refundable,  one-time  upfront  payment  in  April  2023  and  may  be  eligible  to
receive additional development and commercialization milestone payments worth up to $243.0 million. We are also eligible to receive royalties ranging
within the mid-single digits throughout the term of the agreement. The variable consideration related to the remaining development and commercialization
milestone payments was fully constrained at December 31, 2023.

During  the  year  ended  December  31,  2023,  we  recognized  $0.8  million  of  licensing  revenue  pursuant  to  the  METiS  Agreement  upon  delivery  of  the
license.

AstraZeneca AB (AstraZeneca)

In June 2015, we entered into a termination agreement with AstraZeneca (AstraZeneca Termination Agreement) pursuant to which we have agreed to pay
AstraZeneca (i) future royalties at a royalty rate of 10% of net sales of tenapanor or other NHE3 products by us or our licensees, and (ii) 20% of non-
royalty revenue received from a new collaboration partner should we elect to license, or otherwise provide rights to develop and commercialize tenapanor
or other NHE3 products, up to a maximum of $75.0 million in aggregate for (i) and (ii). As of December 31, 2023, to date in aggregate, we have recognized
$27.6 million of the $75.0 million, which has been recorded as other cost of revenue on our statements of operations and comprehensive income (loss).
During the years ended December 31, 2023, 2022, and 2021, we recognized $12.4 million and $3.6 million, and $1.0 million, respectively, as other cost of
revenue related to the AstraZeneca Termination Agreement.

Deferred Revenue

The following tables present changes in our current and non-current deferred revenue balances during the reporting period, which are all attributable to the
2017 Kyowa Kirin Agreement (in thousands):

Balance at January 1,

Amounts invoiced as prepayments for product supply
Decrease for revenue recognized for product supply
Reclassify amounts to be recognized in the next twelve months

Balance at December 31,

2023

2022

Current

Non-Current

Current

Non-Current

$

$

4,211
1,547
(4,586)
6,010
7,182

$

$

9,025
5,629
—
(6,010)
8,644

$

$

— $
250
—
3,961
4,211

$

4,727
8,259
—
(3,961)
9,025

8. DEFERRED ROYALTY OBLIGATION RELATED TO THE SALE OF FUTURE ROYALTIES

In  June  2022,  we  and  HealthCare  Royalty  Partners  IV,  L.P.  (HCR)  entered  into  a  Royalty  and  Sales  Milestone  Interest  Acquisition  Agreement  (HCR
Agreement). Under the terms of the HCR Agreement, HCR has agreed to pay us up to $20.0 million in exchange for the royalty payments and commercial
milestone payments (collectively the Royalty Interest Payments) that we may receive under our 2017 License Agreement with Kyowa Kirin, as amended,
based upon Kyowa Kirin's net sales of tenapanor in Japan for hyperphosphatemia. As consideration for the sale of the Royalty Interest Payments, HCR paid
to us a $10.0 million upfront payment, and we were eligible to receive a $5.0 million payment as a result of Kyowa Kirin's receipt of regulatory approval to
market  tenapanor  for  hyperphosphatemia  in  Japan,  and  another  $5.0  million  payment  in  the  event  net  sales  by  Kyowa  Kirin  in  Japan  exceed  a  certain
annual target level by the end of 2025.

In  September  2023,  we  announced  that  Kyowa  Kirin  received  approval  from  the  Japanese  MHLW  for  the  New  Drug  Application  for  tenapanor  for  the
improvement of hyperphosphatemia in adult patients with chronic kidney disease on dialysis, which entitled us to a $5.0 million payment under the terms
of the HCR Agreement. We received the payment in October 2023.

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The  HCR  Agreement  is  effective  until  terminated  by  the  mutual  agreement  of  the  parties  and  contains  customary  representations  and  warranties  and
customary affirmative and negative covenants, including, among others, requirements as to prosecution, maintenance, defense and enforcement of certain
patent rights in Japan, restrictions regarding our ability to forgive, release or reduce any Royalty Interest Payments due to us under the 2017 Kyowa Kirin
Agreement,  to  create  or  incur  any  liens  with  respect  to  the  Royalty  Interest  Payments,  the  2017  Kyowa  Kirin  Agreement  or  certain  patents,  or  to  sell,
license or transfer certain patents in the field and territory described in the 2017 Kyowa Kirin Agreement.

In addition, the HCR Agreement contains customary events of default with respect to which we may incur indemnification obligations to HCR for any
losses incurred by HCR and related parties as a result of the event of default, subject to a specified limitation of liability cap. Under the HCR Agreement,
an event of default will occur if, among other things, any of the representations and warranties included in the HCR Agreement proves not to have been
true  and  correct  in  all  material  respects,  at  the  time  it  was  made,  we  breach  any  of  our  covenants  under  the  HCR  Agreement,  subject  to  specified  cure
periods  with  respect  to  certain  breaches,  we  are  in  breach  or  default  under  the  2017  Kyowa  Kirin  Agreement  in  any  manner  which  is  likely  to  cause  a
material adverse effect on the Royalty Interest Payments, the occurrence of a termination of the 2017 Kyowa Kirin Agreement under certain circumstances
or we or our assets become subject to certain legal proceedings, such as bankruptcy proceedings, or we are unable to pay our debts as they become due.

The  $10.0  million  upfront  payment  from  HCR  received  in  June  2022  and  the  $5.0  million  payment  received  in  October  2023  have  been  recorded  as  a
deferred royalty obligation related to the sale of future royalties (deferred royalty obligation) on our balance sheets. Due to our ongoing manufacturing
obligations under the 2017 Kyowa Kirin Agreement, we account for the proceeds as imputed debt and therefore will recognize royalties earned under the
arrangement as non-cash royalty revenue. Non-cash interest expense will be recognized over the life of the HCR Agreement using the effective interest
method based on the imputed interest rate derived from estimated amounts and timing of future royalty payments to be received from Kyowa Kirin. As part
of the sale, we incurred approximately $0.4 million in transaction costs, which, along with the deferred royalty obligation, are being amortized to non-cash
interest expense over the estimated life of the HCR Agreement using the effective interest method. As future royalties are remitted to us by Kyowa Kirin,
and subsequently from us to HCR, the balance of the deferred royalty obligation will be effectively repaid over the life of the HCR Agreement. There are a
number of factors that could materially affect the fair value of the deferred royalty obligation. Such factors include, but are not limited to, the amount and
timing  of  potential  future  royalty  payments  to  be  received  from  Kyowa  Kirin  under  the  2017  Kyowa  Kirin  agreement,  changing  standards  of  care,  the
introduction of competing products, manufacturing or other delays, intellectual property matters, adverse events that result in governmental health authority
imposed restrictions on the use of the drug products, significant changes in foreign exchange rates as the royalties remitted to HCR are made in U.S. dollars
while the underlying sales of the products by Kyowa Kirin are made in Japanese yen, and other events or circumstances that could result in reduced royalty
payments from Kyowa Kirin, which are not within our control, and all of which would result in a reduction of non-cash royalty revenues and the non-cash
interest expense over the life of the deferred royalty obligation. We periodically assess the estimated royalty payments from Kyowa Kirin and, to the extent
that the amount or timing of such payments is materially different than our original estimates, we prospectively adjust the imputed interest rate and the
related amortization of the deferred royalty obligation. As of December 31, 2023, our effective interest rate used to amortize the liability is 34.7%. During
the  years  ended  December  31,  2023  and  2022,  we  recognized  approximately  $3.9  million  and  $1.7  million,  respectively,  of  non-cash  interest  expense
related to the deferred royalty obligation. As of December 31, 2023, we have received no royalty payments from Kyowa Kirin and, therefore, the deferred
royalty obligation has not begun to be reduced.

9.     BORROWING

Solar Capital and Western Alliance Bank Loan Agreement

In May 2018, we entered into a loan and security agreement (as amended on October 9, 2020, March 1, 2021, May 5, 2021, and July 29, 2021) (2018 Loan
Agreement) with Solar Capital Ltd. and Western Alliance Bank (collectively, the 2018 Lenders). The 2018 Loan Agreement provided for a loan facility for
up to $50.0 million with a maturity date of November 1, 2022 (2018 Loan). As of the Closing Date for the 2022 Loan, as discussed below, we owed $25.0
million in principal payments from the 2018 Loan, which we repaid in full at that time.

As discussed in Note 10. Derivative Liabilities, in connection with entering into the 2018 Loan Agreement, we entered into an agreement pursuant to which
we  agreed  to  pay  $1.5  million  in  cash  upon  the  occurrence  of  certain  conditions  (2018  Exit  Fee).  Our  obligations  for  the  2018  Exit  Fee  remained
outstanding  following  the  full  repayment  of  the  2018  Loan  in  February  2022  until  October  2023  when  we  received  approval  from  the  U.S.  FDA  for
XPHOZAH  to  reduce  serum  phosphorus  in  adults  with  CKD  on  dialysis  as  add-on  therapy  in  patients  who  have  an  inadequate  response  to  phosphate
binders or who are intolerant of any dose of phosphate binder therapy. This triggered our obligation to pay the 2018 Exit Fee to the 2018 Lenders and we
subsequently paid the 2018 Exit Fee in October 2023.

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SLR Investment Corp. Loan Agreement

On  February  23,  2022  (Closing  Date),  we  entered  into  a  loan  and  security  agreement  (2022  Loan  Agreement)  with  SLR  Investment  Corp.  as  collateral
agent (Agent), and the lenders listed in the 2022 Loan Agreement (collectively, the 2022 Lenders). The 2022 Loan Agreement was subsequently amended
in August 2022 (the First Amendment) and February 2023 (the Second Amendment). We concluded that the First Amendment and the Second Amendment
were modifications to the 2022 Loan Agreement. The 2022 Loan Agreement, as amended by the First Amendment and the Second Amendment, provided
for a senior secured loan facility, with $27.5 million (Term A Loan) funded on the Closing Date and an additional $22.5 million which we may borrow on
or prior to December 20, 2023; provided that (i) we have received approval by the U.S. FDA for our NDA for XPHOZAH by November 30, 2023, and (ii)
we have achieved certain product revenue milestone targets described in the 2022 Loan Agreement (Term B Loan, and together with the Term A Loan, the
2022 Original Loans). The 2022 Term A Loan funds were used to repay the 2018 Loan with the 2018 Lenders.

On October 17, 2023, we entered into a Third Amendment (the Third Amendment) to the 2022 Loan Agreement by and between us and the 2022 Lenders.
The Third Amendment, among other things, (1) provides us with the option to draw an additional $50.0 million of committed capital by March 15, 2024
(the Term C Loan) provided we have drawn the Term B Loan; and (2) provides us with the option to draw up to an additional $50.0 million of uncommitted
capital by December 31, 2026, subject to approval by the Agent’s investment committee (the Term D Loan and together with the Term A, B, and C Loans,
the Four 2022 Loans). We concluded that the Third Amendment was a modification to the 2022 Loan Agreement and is accounted for accordingly. We
expect to provide the Agent with notice of our decision to draw the Term C Loan prior to the expiry of the option on March 15, 2024 to further support the
commercial launch of XPHOZAH.

Under the Third Amendment, the maturity date for the Four 2022 Loans is March 1, 2027. The interest rate for each of the Term A Loan and the Term B
Loan is 7.95% plus a SOFR value equal to 0.022% plus the 1-month CME Term SOFR reference rate as published by the CME Term SOFR Administrator
on the CME Term SOFR Administrator’s Website, subject to a SOFR floor of one percent. The interest rate for each of the Term C Loan and the Term D
Loan is 4.25% plus a SOFR value equal to 0.022% plus the 1-month CME Term SOFR reference rate as published by the CME Term SOFR Administrator
on the CME Term SOFR Administrator’s Website, subject to a SOFR floor of 4.7%.

In  addition,  the  period  under  which  we  are  permitted  to  make  interest-only  payments  on  the  Four  2022  Loans  was  extended  to  December  31,  2026,
effective upon our decision to draw the Term B Loan in the amount of $22.5 million. In October 2023, we provided the Agent with notice of our decision to
draw the Term B Loan to support the commercial launch of XPHOZAH and received the proceeds of the Term B Loan.

We were obligated to pay $0.2 million, upon the closing of the Term A Loan, and we were obligated to pay $0.1 million on the funding date of the Term B
Loan.  We  are  obligated  to  pay  $0.3  million  on  the  earliest  of  (1)  the  funding  date  of  the  Term  C  Loan,  (2)  March  15,  2024,  and  (3)  the  prepayment,
refinancing, substitution or replacement of the Term B Loans on or prior to March 15, 2024. In addition, we will be obligated to pay 0.5% of the aggregate
original principal amount of the Term D Loan commitment, if requested by us and approved by the Agent’s investment committee, which shall be due on
the earliest of (1) the funding of the Term D Loan, (2) if we request and the 2022 Lenders provide the Term D Loan commitment, the day immediately
preceding  the  amortization  date,  and  (3)  if  we  request  and  the  2022  Lenders  provide  the  Term  D  Loan  commitment,  the  prepayment,  refinancing,
substitution or replacement of the Term C Loan on or prior to the date immediately preceding the amortization date.

We are obligated to pay a final fee equal to 4.95% of the aggregate original principal amount of the Four 2022 Loans, to the extent such loans are funded,
upon the earliest to occur of the maturity date, the acceleration of the Four 2022 Loans, and the prepayment, refinancing, substitution, or replacement of the
Four 2022 Loans.

We may voluntarily prepay all amounts outstanding under the Four 2022 Loans, subject to a prepayment premium of (i) 3% of the outstanding principal
amount of the Four 2022 Loans if prepaid prior to or on October 17, 2024, (ii) 2% of the outstanding principal amount of the Four 2022 Loans if prepaid
after October 17, 2024 through and including October 17, 2025, or (iii) 1% of the outstanding principal amount of the Four 2022 Loans if prepaid after
October 17, 2025 and prior to the maturity date. The Four 2022 Loans are secured by substantially all of our assets, except for our intellectual property and
certain other customary exclusions. Additionally, as discussed in Note 10. Derivative Liabilities, in connection with the 2022 Original Loans, we entered
into an agreement whereby we agreed to pay an exit fee in the amount of 2% of the 2022 Original Loans funded (2022 Exit Fee). Notwithstanding the
prepayment or termination of the 2022 Loan, the 2022 Exit Fee will expire 10 years from the Closing Date.

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The 2022 Loan Agreement, as amended, contains customary representations and warranties and customary affirmative and negative covenants, including,
among others, requirements as to financial reporting and insurance and restrictions on our ability to dispose of our business or property, to change our line
of  business,  to  liquidate  or  dissolve,  to  enter  into  any  change  in  control  transaction,  to  merge  or  consolidate  with  any  other  entity  or  to  acquire  all  or
substantially all the capital stock or property of another entity, to incur additional indebtedness, to incur liens on our property, to pay any dividends or other
distributions on capital stock other than dividends payable solely in capital stock or to redeem capital stock. We have agreed to not allow our cash and cash
equivalents to be less than the eighty percent (80%) of the outstanding Four 2022 Term Loan balance for any period in which our net revenue from the sale
of any products, calculated on a trailing six (6) month basis and tested monthly, is less than sixty percent (60%) of the outstanding Four 2022 Loan balance.

In addition, the 2022 Loan Agreement, as amended, contains customary events of default that entitle the Agent to cause our indebtedness under the 2022
Loan  Agreement  to  become  immediately  due  and  payable,  and  to  exercise  remedies  against  us  and  the  collateral  securing  the  Four  2022  Term  Loans,
including our cash. Under the 2022 Loan Agreement, an event of default will occur if, among other things, we fail to make payments under the 2022 Loan
Agreement, we breach any of our covenants under the 2022 Loan Agreement, subject to specified cure periods with respect to certain breaches, certain
Lenders  determine  that  a  material  adverse  change  has  occurred,  we  or  our  assets  become  subject  to  certain  legal  proceedings,  such  as  bankruptcy
proceedings,  we  are  unable  to  pay  our  debts  as  they  become  due  or  we  default  on  contracts  with  third  parties  which  would  permit  the  holder  of
indebtedness to accelerate the maturity of such indebtedness or that could have a material adverse change on us. Upon the occurrence and for the duration
of an event of default, an additional default interest rate equal to 4% per annum will apply to all obligations owed under the 2022 Loan Agreement. We
have classified the 2022 Original Loan balance as a non-current liability as of December 31, 2023 due to principal repayments beginning in January 2027.
We have concluded that the provisions that could cause acceleration of the principal repayments are remote.

As of December 31, 2023, our future payment obligations related to the 2022 Loan, excluding interest payments and the 2022 final fee, were as follows (in
thousands):
2024
2025
2026
2027

$

Thereafter

Total repayment obligations
Less: Unamortized discount and debt issuance costs

Less: Unaccreted value of final fee
Long-term debt
Less: Current portion of long-term debt

Long-term debt, net of current portion

10.    DERIVATIVE LIABILITIES

2018 Exit Fee

$

— 
— 
— 
52,475 
— 
52,475 
(912)
(1,741)
49,822 
— 
49,822 

In May 2018, in connection with entering into the 2018 Loan Agreement, we entered into an agreement pursuant to which we agreed to pay $1.5 million in
cash (2018 Exit Fee) upon any change of control transaction in respect of the Company or if we obtain both (i) U.S. FDA approval of XPHOZAH and (ii)
U.S. FDA approval of IBSRELA, which was obtained on September 12, 2019 (2018 Exit Fee Agreement). Notwithstanding the February 2022 prepayment
of the 2018 Loan, our obligation to pay the 2018 Exit Fee would have expired on May 16, 2028. We concluded that the 2018 Exit Fee was a freestanding
derivative which should be accounted for at fair value on a recurring basis.

In October 2023, we received approval from the U.S. FDA for XPHOZAH to reduce serum phosphorus in adults with chronic kidney disease (CKD) on
dialysis as add-on therapy in patients who have an inadequate response to phosphate binders or who are intolerant of any dose of phosphate binder therapy.
This triggered our obligation to pay the 2018 Exit Fee to the 2018 Lenders, which we subsequently paid in October 2023. The estimated fair value of the
2018 Exit Fee was recorded as a derivative liability and included in accrued expense and other current liabilities on the accompanying balance sheets. As of
December 31, 2023 and December 31, 2022, the estimated fair value of the 2018 Exit Fee was zero and $1.2 million, respectively.

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The  fair  value  of  the  derivative  liability  at  December  31,  2022  was  determined  using  a  discounted  cash  flow  analysis  and  was  classified  as  a  Level  3
measurement within the fair value hierarchy since our valuation utilized significant unobservable inputs. Specifically, the key assumptions included in the
calculation of the estimated fair value of the derivative instrument included: (i) our estimates of both the probability and timing of a potential $1.5 million
payment to the 2018 Lenders as a result of the U.S. FDA approvals, and (ii) a discount rate which was derived from our estimated cost of debt, adjusted
with current LIBOR.

2022 Exit Fee

In February 2022, in connection with entering into the 2022 Original Loans, we entered into an agreement, whereby we agreed to pay an exit fee in the
amount of 2% of the 2022 Original Loan funded (2022 Exit Fee) upon (i) any change of control transaction or (ii) our achievement of net revenue from the
sale of any products equal to or greater than $100.0 million, measured on a six (6) months basis (Revenue Milestone), tested monthly at the end of each
month.  The  Term  C  and  Term  D  Loans  do  not  result  in  payment  of  an  additional  exit  fee.  Notwithstanding  the  prepayment  or  termination  of  the  2022
Original Loans, the 2022 Exit Fee will expire on February 23, 2032. We concluded that the 2022 Exit Fee is a freestanding derivative which should be
accounted for at fair value on a recurring basis. The estimated fair value of the 2022 Exit Fee is recorded as a derivative liability and included in accrued
expenses and other current liabilities on the accompanying balance sheets. As of December 31, 2023 and December 31, 2022, the estimated fair value of
the 2022 Exit Fee was $0.7 million and $0.4 million, respectively.

The fair value of the derivative liability was determined using a discounted cash flow analysis and is classified as a Level 3 measurement within the fair
value hierarchy since our valuation utilized significant unobservable inputs. Specifically, the key assumptions included in the calculation of the estimated
fair value of the 2022 Exit Fee derivative liability include: (i) our estimates of both the probability and timing of achieving the Revenue Milestone and (ii)
the probability and timing of funding the Term B Loan, which was dependent upon (a) approval by the U.S. FDA for our NDA for the control of serum
phosphorus  in  adult  patients  with  CKD  on  dialysis  by  November  30,  2023,  and  (b)  achievement  of  certain  product  revenue  milestone  targets.  As  of
December 31, 2023, uncertainty around two of the noted valuation estimates had been removed, as the Term B Loan had been funded and the U.S. FDA
had approved our NDA for the control of serum phosphorus in adult patients with CKD on dialysis prior to November 30, 2023. Generally, increases or
decreases in the probability of occurrence would result in a directionally similar impact in the fair value measurement of the derivative liability and it is
estimated that a 10% increase (decrease) in the probability of occurrence would not result in a material fair value fluctuation.

Changes in the fair value of recurring measurements included in Level 3 of the fair value hierarchy are presented as other income, net in our statements of
operations and comprehensive income (loss) and were as follows for the years ended December 31, 2023, 2022, and 2021 (in thousands):

Balance at January 1,

2022 Exit Fee addition at fair value

Changes in estimated fair value:

2018 Exit Fee
2022 Exit Fee

2018 Exit Fee payment

Fair value of exit fee derivative liabilities at December 31,

11.     LEASES

2023

2022

$

$
$

1,656  $
— 

292 
227 
(1,500) $
675  $

698 
375 

510 
73 
— 
1,656 

We  have  recorded  right-of-use  operating  lease  assets  under  three  lease  agreements.  We  have  evaluated  our  facility  leases  and  determined  that,  effective
upon the adoption of Topic 842, the leases evaluated are all operating leases. We have performed an evaluation of our other contracts with suppliers and
collaborators in accordance with Topic 842 and have determined that, except for the facility leases described below, none of our contracts contain a lease.

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We recorded right-of-use operating lease assets for our facility in Waltham, Massachusetts under a lease agreement entered into during December 2020
with lease commencement dates during April and May 2021. In August 2023, we entered into an amendment to the lease agreement to expand the leased
premises to include an additional 4,247 square feet of office space. As of December 31, 2023, the Waltham office space consists of 17,111 square feet with
the lease terminating in June 2026. We have an option to extend the lease term for one additional five year period. This option to extend the lease term has
not  been  included  in  the  calculation  of  the  right-of-use  asset  and  lease  liability  since  the  exercise  of  the  option  is  uncertain  and  therefore  deemed  not
probable. We recorded a $1.6 million right-of-use asset and lease liability for the Waltham lease upon commencement of the lease and an additional $0.3
million right-of-use asset and lease liability upon commencement of the lease amendment.

We have also recorded a right-of-use operating lease asset for our facility located in Fremont, California under a lease agreement entered into in September
2008 that was amended multiple times to add space and to extend the lease term through March 2025. The office space consists of 72,500 square feet. We
do not have an option to renew the lease at our current Fremont location beyond March 2025. In March 2023, we entered into a sub-lease Agreement (Sub-
lease) with Chronus Health, Inc. (Chronus). We have sub-leased to Chronus approximately 21,644 square feet of the 72,500 square foot building's interior
space, plus corresponding exterior support space and parking. The term of the Sub-lease expires on February 1, 2025. In accordance with the Sub-lease, we
recognized  an  impairment  of  long-lived  assets  totaling  $0.4  million  during  the  three  months  ended  March  31,  2023,  which  consisted  primarily  of
impairment to the Fremont facility right-of-use asset, as determined by measuring the undiscounted future cash flows from the sub-leased space. The Sub-
lease commenced in April 2023 and we recognized $0.8 million of income from the Sub-lease during the year ended December 31, 2023.

We have recorded a right-of-use operating lease asset for our facility located in Milwaukee, Wisconsin under a lease agreement entered into in October
2020 with a lease commencement date in November 2020. The office space consists of 4,768 square feet with the lease terminating in February 2026. We
have an option to extend the lease term by one additional five-year period. This option to extend the lease term has not been included in the calculation of
the right-of-use asset and lease liability since the exercise of the option is uncertain and therefore deemed not probable. We recorded a $0.4 million right-of
use asset and lease liability for the Milwaukee lease upon commencement of the lease.

All of our leases are operating leases and each contain customary rent escalation clauses. Certain of the leases have both lease and non-lease components.
We  have  elected  to  account  for  each  separate  lease  component  and  the  non-lease  components  associated  with  that  lease  component  as  a  single  lease
component for all classes of underlying assets.

The following table provides additional details of our facility leases presented in our balance sheets (dollars in thousands):

Facilities

Right-of-use assets

Current portion of lease liabilities
Operating lease liability, net of current portion

Total lease liabilities

Weighted-average remaining life (years)
Weighted-average discount rate

$

$

December 31,

2023

2022

5,589 

$

9,295 

4,435 
1,725 
6,160 

$

1.6
6.8 %

3,894 
5,855 
9,749 

2.4
6.8 %

The lease costs, which are included in operating expenses in our statements of operations, were as follows (in thousands):

Operating lease expense
Cash paid for operating lease

Year Ended December 31,

2023

2022

2021

$
$

3,857  $
4,481  $

4,257  $
4,292  $

3,671 
3,438 

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The following table summarizes our undiscounted cash payment obligations for our operating lease liabilities as of December 31, 2023 (in thousands):

Ending December 31,
2024
2025
2026
Thereafter
Total undiscounted operating lease payments
Imputed interest expenses

Total operating lease liabilities

Less: Current portion of operating lease liability

Operating lease liability, net of current portion

12.     STOCKHOLDERS’ EQUITY

$

$

4,715 
1,450 
329 
— 
6,494 
(334)
6,160 
(4,435)
1,725 

In  July  2020,  we  filed  a  Form  S-3  registration  statement,  which  became  effective  in  August  2020  (2020  Registration  Statement),  containing  (i)  a  base
prospectus for the offering, issuance and sale by us of up to a maximum aggregate offering price of $250.0 million of our common stock, preferred stock,
debt securities, warrants and/or units, from time to time in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by us
of  up  to  a  maximum  aggregate  offering  price  of  $100.0  million  of  our  common  stock  that  may  be  issued  and  sold,  from  time  to  time,  under  a  sales
agreement with Jefferies LLC (Jefferies), deemed to be “at-the-market offerings” (2020 Open Market Sales Agreement). Pursuant to the 2020 Open Market
Sales Agreement, Jefferies, as sales agent, received a commission of up to 3.0% of the gross sales price for shares of common stock sold under the 2020
Open Market Sales Agreement. As of December 31, 2021, we had sold 23.3 million shares and received the maximum gross proceeds of $100.0 million
pursuant to the 2020 Open Market Sales Agreement at a weighted average share prices of $4.30 per share.

In August 2021, we filed an additional prospectus supplement under the 2020 Registration Statement for the offering, issuance and sale by us of up to a
maximum  aggregate  offering  price  of  $150.0  million  of  our  common  stock  that  may  be  issued  and  sold,  from  time  to  time,  under  an  additional  sales
agreement we entered into with Jefferies (2021 Open Market Sales Agreement), pursuant to which we may, from time to time, sell up to $150.0 million in
shares of our common stock through Jefferies. We are required to sell shares under the 2021 Open Market Sales Agreement. Pursuant to the 2021 Open
Market Sales Agreement, Jefferies, as our sales agent, receives a commission of up to 3.0% of the gross sales price for shares of common stock sold under
the 2021 Open Market Sales Agreement. As of March 2023, we had received the maximum gross proceeds of $150.0 million under the 2021 Open Market
Sales Agreement at a weighted average share price of approximately $1.57 per share, which included 15.5 million shares of our common stock for which
we received gross proceeds of $51.9 million at a weighted average share price of approximately $3.35 during the quarter ended March 31, 2023.

In January 2023, we filed a Form S-3 registration statement, which became effective in January 2023 (2023 Registration Statement), containing (i) a base
prospectus for the offering, issuance and sale by us of up to a maximum aggregate offering price of $250.0 million of our common stock, preferred stock,
debt securities, warrants and/or units, from time to time in one or more offerings; and (ii) a prospectus supplement for the offering, issuance and sale by us
of  up  to  a  maximum  aggregate  offering  price  of  $150.0  million  of  our  common  stock  that  may  be  issued  and  sold,  from  time  to  time,  under  a  sales
agreement  with  Jefferies,  deemed  to  be  “at-the-market  offerings”  (2023  Open  Market  Sales  Agreement).  Pursuant  to  the  2023  Open  Market  Sales
Agreement, Jefferies, as sales agent, may receive a commission of up to 3.0% of the gross sales price for shares of common stock sold under the 2023 Open
Market Sales Agreement. During the year ended December 31, 2023, we sold 16.8 million shares of our common stock and received gross proceeds of
$70.0 million at a weighted average sales price of approximately $4.17 per share under the 2023 Open Market Sales Agreement.

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13.    EQUITY INCENTIVE PLANS

2008 Plan

We granted options under our 2008 Stock Incentive Plan (2008 Plan) until June 2014 when it was terminated as to future awards, although it continues to
govern the terms of options that remain outstanding under the 2008 Plan. The 2008 Plan provided for the granting of incentive and non-qualified stock
options, and stock purchase rights to employees, directors and consultants at the discretion of the board of directors. Stock options granted generally vested
over a period of four years from the date of grant. In connection with the board of directors and stockholders’ approval of the 2014 Plan, all remaining
shares available for future award under the 2008 Plan were transferred to 2014 Plan, as discussed below, and the 2008 Plan was terminated.

2014 Plan

The 2014 Equity Incentive Award Plan (2014 Plan) became effective on June 18, 2014. Under the 2014 Plan, 1.4 million shares of common stock were
initially  reserved  for  issuance  pursuant  to  a  variety  of  stock-based  compensation  awards,  including  stock  options,  stock  appreciation  rights  (SARs),
restricted stock awards, service-based restricted stock unit (RSU) awards, performance-based restricted stock unit (PRSU) awards, deferred stock awards,
deferred  stock  unit  awards,  dividend  equivalent  awards,  stock  payment  awards  and  performance  awards.  In  addition,  35  thousand  shares  that  had  been
available for future awards under the 2008 Plan as of June 18, 2014, were added to the initial reserve available under the 2014 Plan, bringing the total
reserve upon the effective date of the 2014 Plan to 1.5 million shares. The number of shares initially reserved for issuance or transfer pursuant to awards
under the 2014 Plan will be increased by (i) the number of shares represented by awards outstanding under 2008 Plan on June 18, 2014, that are either
forfeited or lapse unexercised or that are repurchased for the original purchase price thereof, up to a maximum of 1.2 million shares, and (ii) if approved by
the administrator of the 2014 Plan, an annual increase on the first day of each fiscal year ending in 2024 equal to the lesser of (A) four percent (4.0%) of the
shares of stock outstanding (on an as converted basis) on the last day of the immediately preceding fiscal year and (B) such smaller number of shares of
stock  as  determined  by  our  board  of  directors;  provided,  however,  that  no  more  than  10.7  million  shares  of  stock  may  be  issued  upon  the  exercise  of
incentive stock options. As of December 31, 2023, approximately 2.5 million shares of our common stock were available for future issuance under the
2014 Plan.

2016 Plan

In  November  2016,  our  board  of  directors  approved  the  2016  Employment  Commencement  Incentive  Plan  (Inducement  Plan)  under  which  1.0  million
shares  were  reserved.  In  January  2021,  January  2022,  December  2022  and  January  2024,  0.5  million,  2.0  million,  3.0  million  and  5.8  million  shares,
respectively, were added to the Inducement Plan. As of December 31, 2023, 6.0 million shares of our common stock were subject to inducement grants that
were issued pursuant to the Inducement Plan. As of December 31, 2023, approximately 0.9 million shares of our common stock were available for future
issuance under the 2016 Plan.

Stock Options

A summary of our stock option activity and related information during the year ended December 31, 2023 is as follows (in thousands, except per share
dollar amounts and years):

Balance at December 31, 2022
Options granted
Options exercised
Options canceled

Balance at December 31, 2023

Vested and expected to vest at December 31, 2023

Exercisable at December 31, 2023

Options Issued and Outstanding

Number of Shares

Weighted-Average
Exercise Price 
per Share

Weighted
Average
Remaining
Contractual Term
(in Years)

Aggregate
Intrinsic Value

13,963  $
8,914  $
(226) $
(483) $
22,168  $
22,168  $
12,199  $

4.83 
3.14 
1.61 
3.83 

4.20 

4.20 

5.30 

7.3 $

7.3 $

6.1 $

58,606 

58,606 

25,116 

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The aggregate intrinsic value represents the difference between the total pre-tax value (i.e., the difference between our stock price and the exercise price) of
stock options outstanding as of December 31, 2023, based on our common stock closing price of $6.20 per share, which would have been received by the
option holders if all their in-the-money options had been exercised as of that date.

The  intrinsic  value  of  options  exercised  during  the  years  ended  December  31,  2023,  2022  and  2021,  was  $1.1  million,  $30  thousand,  and  $1.7  million,
respectively.

The weighted-average grant-date estimated fair value of options granted during the years ended December 31, 2023, 2022 and 2021 was $2.36, $0.63 and
$3.92 per share, respectively. The estimated grant date fair value of employee stock options was calculated using the Black-Scholes option-pricing model,
based on the following weighted-average assumptions:

Expected term (years)
Expected volatility
Risk-free interest rate
Dividend yield

Year Ended December 31,

2023

2022

2021

5.1
97.6 %
3.8 %
— %

4.9
92.1 %
2.2 %
— %

5.0
77.0 %
4.7 %
— %

Expected Term—We  have  limited  historical  information  to  develop  reasonable  expectations  about  future  exercise  patterns  and  post-vesting  employment
termination behavior for its stock-option grants. As such, the expected term was initially estimated using the simplified method whereby the expected term
equals the arithmetic average of the vesting term and the original contractual term of the option. Beginning in 2021, we estimate the expected term of our
options  based  upon  historical  exercises  and  post-vesting  termination  behavior,  which  has  not  resulted  in  a  material  difference  as  compared  to  using  the
simplified method.

Expected Volatility—Since  January  1,  2017,  we  use  the  historic  volatility  of  our  own  stock  over  the  retrospective  period  corresponding  to  the  expected
remaining term of the options, or the period since our shares were first quoted on The Nasdaq Global Market, if that is shorter, to compute our expected
stock price volatility.

Risk-Free Interest Rate—The risk-free interest rate assumption is based on the zero-coupon U.S. treasury instruments on the date of grant with a maturity
date consistent with the expected term of our stock option grants.

Dividend Yield—To date, we have not declared or paid any cash dividends and do not have any plans to do so in the future. Therefore, we use an expected
dividend yield of zero.

Restricted Stock Units

A  summary  of  our  RSUs  activity  and  related  information  for  the  year  ended  December  31,  2023  is  as  follows  (in  thousands,  except  per  share  dollar
amounts):

Non-vested restricted stock units at December 31, 2022

Granted
Vested
Forfeited

Non-vested restricted stock units at December 31, 2023

Number of
RSUs

Weighted-Average
Grant Date Fair
Value Per Share

1,406  $
3,269  $
(942) $
(87) $
3,646  $

2.17 
3.39 
2.76 
3.05 

3.09 

The total estimated fair value of RSUs vested during the years ended December 31, 2023, 2022 and 2021 was $3.5 million, $2.6 million and $0.8 million,
respectively.

Issuance of Common Stock for Services

During  the  years  ended  December  31,  2023,  2022  and  2021,  we  issued  approximately  0.1  million,  0.7  million  and  26  thousand  shares,  respectively,  of
common stock to members of the board of directors who elected to receive stock in lieu of

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their cash fees under our Non-Employee Director Compensation Program. The shares issued during the years ended December 31, 2023, 2022 and 2021
were valued at $0.3 million, $0.4 million and $0.2 million for each year, respectively, based on the fair value of the common stock on the date of grant.

Employee Stock Purchase Plan

We adopted the 2014 Employee Stock Purchase Plan (ESPP) and initially reserved approximately 0.2 million shares of common stock as of its effective
date of June 18, 2014. If approved by the administrator of the ESPP, on the first day of each calendar year, ending in 2024, the number of shares in the
reserve  will  increase  by  an  amount  equal  to  the  lesser  of  (i)  one  percent  (1.0%)  of  the  shares  of  common  stock  outstanding  on  the  last  day  of  the
immediately preceding fiscal year and (ii) such number of shares of common stock as determined by the board of directors; provided, however, no more
than 2.2 million shares of our common stock may be issued under the ESPP.

During the years ended December 31, 2023, 2022 and 2021, we issued approximately 436 thousand, 308 thousand and 387 thousand shares, respectively, at
an average share price of $1.85, $0.63 and $2.12, respectively, pursuant to the ESPP. As of December 31, 2023, approximately 1.1 million shares of our
common stock were available for future issuance under the ESPP.

The following table illustrates the weighted-average assumptions for the Black-Scholes option-pricing model used in determining the fair value of ESPP
purchase rights granted to our employees:

Expected term (years)
Expected volatility
Risk-free interest rate
Dividend yield

Stock-based Compensation Expense

Year Ended December 31,

2023

2022

2021

0.5
86.0 %
5.3 %
— %

0.5
97.2 %
1.9 %
— %

0.5
123.0 %
0.7 %
— %

Stock-based compensation expense recognized for stock options, RSUs, and our ESPP are recorded as operating expenses in our statements of operations
and comprehensive loss, as follows (in thousands):

Selling, general and administrative
Research and development

Total

Year Ended December 31,

2023

2022

2021

$

$

9,952  $
3,578 
13,530  $

7,525  $
3,225 
10,750  $

7,923 
4,116 
12,039 

A summary of our total unrecognized stock-based compensation expense, net of estimated forfeitures, as of December 31, 2023 is as follows (dollars in
thousands):

Stock option grants
RSU grants
ESPP

14.     RESTRUCTURING

December 31, 2023

Unrecognized Compensation Expense

$
$
$

19,960 
10,579 
154 

Average Remaining Vesting Period
(Years)
2.75
3.03
0.2

During 2021, we implemented restructuring plans in August and October following the receipt of a Complete Response Letter (CRL) from the U.S. FDA
relating  to  our  NDA  for  XPHOZAH  and  following  the  conclusion  of  an  End  of  Review  Type  A  meeting  with  the  U.S.  FDA,  respectively.  Both
restructuring plans were substantially completed in December 2021 and most of the cash payments related to the reduction in workforce were disbursed
prior to December 31, 2021.

In connection with restructuring, we incurred restructuring charges of $6.2 million, which were recorded during the year ended December 31, 2021, related
to one-time termination notice and severance payments and other employee-related costs.

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We  did  not  incur  any  significant  contract  termination  costs  pursuant  to  restructuring.  Of  the  charges,  $2.7  million  was  recorded  in  research  and
development  expenses,  and  $3.5  million  was  recorded  in  selling,  general  and  administrative  expense  in  the  accompanying  statements  of  operations  and
comprehensive loss.

15.     PROPERTY AND EQUIPMENT, NET

Property and equipment consist of the following (in thousands):

Laboratory equipment
Office equipment and furniture
Leasehold improvements

Property and equipment, gross
Less: accumulated depreciation

Total property and equipment, net

December 31,

2023

2022

$

$

46  $

2,433 
8,731 
11,210 
(10,201)

1,009  $

46 
2,089 
8,745 
10,880 
(9,657)
1,223 

We recognized depreciation expense in the amount of $0.6 million, $0.7 million, and $1.4 million for the years ended December 31, 2023, 2022 and 2021,
respectively.

During the year ended December 31, 2022, following the elimination of our internal research organization in the fourth quarter of 2021, we sold laboratory
equipment  with  total  net  carrying  value  of  $0.5  million  and  received  cash  proceeds  of  $1.8  million,  resulting  in  a  gain  of  $1.3  million  which  has  been
reported within other income, net on our statement of operations and comprehensive loss.

16.     ACCRUED EXPENSES AND OTHER CURRENT LIABILITIES

Accrued expenses and other current liabilities consist of the following (in thousands):

Accrued payments due to AstraZeneca
Accrued gross to net revenue liabilities
Accrued contract manufacturing expenses
Accrued sales and marketing expenses
Accrued professional and consulting services
Derivative liability for exit fees
Accrued clinical expenses
Accrued non-clinical research and development expenses
Other

Total accrued expenses and other current liabilities

105

December 31,

2023

2022

$

$

3,680  $
3,258 
1,946 
3,223 
486 
675 
377 
30 
1,366 
15,041  $

3,385 
1,991 
1,657 
587 
808 
1,656 
223 
1,188 
885 
12,380 

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17.    INCOME TAXES

The components of our provision for income taxes for the years ended December 31, 2023, 2022 and 2021, are as follows (in thousands):

Current:
State
Foreign
Total current

Deferred:
Federal
Total deferred

Provision for income taxes

A reconciliation of the statutory federal income tax rate to our effective tax rate is as follows:

Income tax at the federal statutory rate
State taxes, net of federal benefit
Tax credits
Stock based compensation
Foreign withholding tax
Executive compensation disallowed under IRC Sec 162(m)
Other
Change in valuation allowance

Income tax provision

Year Ended December 31,
2022

2023

2021

$

$

47  $
500 
547 

— 
— 
547  $

8  $

— 
8 

— 
— 

8  $

4 
— 
4 

— 
— 
4 

Year Ended December 31,
2022

2023

2021

21.0 %
3.4 
1.7 
0.1 
(0.8)
(1.9)
— 
(24.3)
(0.8)%

21.0 %
1.9 
1.5 
(2.3)
— 
(1.6)
(0.8)
(19.7)

— %

21.0 %
0.4 
1.0 
(1.3)
— 
(1.1)
— 
(20.0)

— %

Deferred income taxes reflect the tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes
and the amounts used for income tax purposes. Significant components of our deferred tax assets are as follows as of December 31, 2023 and 2022 (in
thousands):

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Deferred tax assets:

Amortization and depreciation
Net operating loss carryforwards
Tax credits
Stock-based compensation
Deferred royalty obligation
Other

Gross deferred tax assets

Valuation allowance

Deferred tax assets net of valuation allowance

Deferred tax liabilities:
Right-of-use asset
Other

Net deferred tax assets

December 31,

2023

2022

$

$

64,919  $
98,702 
15,375 
6,946 
4,907 
6,707 
197,556 
(196,197)
1,359 

(1,359)
— 
—  $

64,111 
86,547 
14,411 
5,244 
2,577 
4,909 
177,799 
(175,670)
2,129 

(2,129)
— 
— 

Realization of deferred tax assets is dependent on future taxable income, if any, the timing and the amount of which are uncertain. We assess the available
positive and negative evidence to estimate whether sufficient future taxable income will be generated to permit use of the existing deferred tax assets. A
significant component of objective negative evidence evaluated was our cumulative loss incurred over the three-year period ended December 31, 2023.
Such objective evidence limits the ability to consider other subjective evidence, such as our projections for future growth. On the basis of this evaluation, as
of December 31, 2023, 2022 and 2021, a full valuation allowance has been recorded against our net deferred tax asset. The valuation allowance increased
by $20.5 million in 2023 primarily due to increases in net operating losses. The amount of the deferred tax asset considered realizable, however, could be
adjusted  if  estimates  of  future  taxable  income  during  the  carryforward  period  are  reduced  or  increased  or  if  objective  negative  evidence  in  the  form  of
cumulative losses is no longer present and additional weight is given to subjective evidence such as our projections for growth.

As  of  December  31,  2023,  we  had  net  operating  loss  carryforwards  for  federal  income  tax  purposes  of  approximately  $479.0  million,  of  which
approximately $328.8 million can be carried forward indefinitely and the remaining net operating losses expire beginning in 2030, if not utilized. Federal
research  and  development  tax  credit  carryforwards  of  approximately  $17.8  million  that  expire  beginning  in  2027,  if  not  utilized,  and  foreign  tax  credit
carryforwards of approximately $1.7 million that begin to expire in 2027, if not utilized.

In addition, we had net operating loss carryforwards for California income tax purposes of approximately $92.9 million that expire beginning of 2030, if
not utilized, and state research and development tax credit carryforwards of approximately $8.9 million which can be carried forward indefinitely. We had
approximately $0.1 million of minimum tax credit carryovers for California income tax purposes. The minimum tax credits have no expiration date. We
had other state net operating losses of approximately $50.5 million that begin to expire in 2031.

The future utilization of net operating loss and tax credit carryforwards and credits may be subject to an annual limitation, pursuant to Internal Revenue
Code Sections 382 and 383, as a result of ownership changes that may have occurred previously or that could occur in the future. Due to the existence of
the valuation allowance, limitations under Section 382 and 383 will not impact our effective tax rate.

Under the Tax Cuts and Jobs Act of 2017, research and development costs are no longer fully deductible and are required to be capitalized and amortized
for U.S. tax purposes effective January 1, 2022. The mandatory capitalization requirement did not have a material impact on our deferred tax assets and did
not result in a cash tax liability as we have historically elected to capitalized research and development expenses for tax purposes.

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A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

Balance at beginning of year
Additions based on tax positions related to current year
Additions based on tax positions related to prior year
Subtractions based on tax positions related to prior year

Balance at end of year

2023

December 31,
2022

2021

$

$

24,075  $
262 
99 
(811)
23,625  $

24,426  $
460 
— 
(811)
24,075  $

23,624 
1,613 
— 
(811)
24,426 

We recognize a tax benefit from an uncertain tax position when it is more likely than not that the position will be sustained upon examination, including
resolutions of any related appeals or litigation processes, based on the technical merits. Income tax positions must meet a more likely than not recognition
at the effective date to be recognized. None of our unrecognized tax benefits would impact the effective tax rate if recognized, because the benefit would be
offset by an increase in the valuation allowance.

We have elected to include interest and penalties as a component of tax expense. During the years ended December 31, 2023, 2022 and 2021, we did not
recognize accrued interest and penalties related to unrecognized tax benefits. Although the timing and outcome of an income tax audit is highly uncertain,
we do not anticipate that the amount of existing unrecognized tax benefits will significantly change during the next 12 months.

We  file  a  U.S.  federal  income  tax  return  and  income  tax  returns  in  various  state  and  local  jurisdictions.  Due  to  our  net  operating  loss  and  tax  credit
carryforwards,  the  income  tax  returns  remain  open  to  U.S.  federal  and  state  tax  examinations.  We  are  not  currently  under  examination  in  any  tax
jurisdiction.

18.    GEOGRAPHIC INFORMATION AND CONCENTRATIONS

Revenues  are  attributed  to  geographical  areas  based  on  the  location  at  which  we  earned  revenue  for  product  sales  of  IBSRELA  and  XPHOZAH  or  the
domicile  of  our  collaboration  partners.  A  summary  of  our  revenue  by  geographic  areas  for  the  years  ended  December  31,  2023,  2022  and  2021,  is  as
follows (in thousands):

United States (1)
International:

Asia Pacific (2)
North America (3)

Total revenue

Year Ended December 31,
2022

2023

2021

83,276  $

15,600  $

— 

41,121 
59 
124,456  $

36,527 
31 
52,158  $

10,084 
13 
10,097 

$

$

(1) Revenues from the United States are primarily comprised of amounts earned from sales of IBSRELA and XPHOZAH, as well as the upfront license

fee from the METiS Agreement.

(2) Revenues from Asia Pacific are primarily comprised of amounts earned in accordance with the 2017 Kyowa Kirin Agreement, the 2019 Kyowa Kirin

Agreement and the Fosun Agreement.

(3) Revenues from North America are comprised of amounts earned from Canada in accordance with the Knight Agreement.

Revenues from Customers and collaboration partnerships accounting for more than 10% of total revenues during the years ended December 31, 2023, 2022
and 2021 were as follows:

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Kyowa Kirin
Bioridge Phama
Cardinal
AmerisourceBergen Drug Corporation
McKesson

19.    NET LOSS PER SHARE

Year Ended December 31,
2022

2021

2023

29.0 %
24.0 %
19.8 %
19.1 %
15.7 %

70.0 %
3.2 %
9.6 %
11.1 %
8.9 %

100.0 %
— %
— %
— %
— %

Basic net loss per share is calculated by dividing net loss by the weighted-average number of common shares outstanding during the period and excludes
any  dilutive  effects  of  stock-based  awards  and  warrants.  Diluted  net  loss  per  common  share  is  computed  giving  effect  to  all  potential  dilutive  common
shares, including common stock issuable upon exercise of stock options, and unvested restricted common stock and stock units. As we had net losses for
the years ended December 31, 2023, 2022 and 2021, all potential common shares were determined to be anti-dilutive.

The following table sets forth the computation of net loss per common share (in thousands, except per share dollar amounts):

Numerator:

Net loss
Denominator:

Weighted average common shares outstanding - basic and diluted

Net loss per share - basic and diluted

Year Ended December 31,
2022

2023

2021

$

$

(66,067) $

(67,207) $

(158,165)

219,331 

158,690 

(0.30) $

(0.42) $

104,206 

(1.52)

For the years ended December 31, 2023, 2022 and 2021, the total numbers of securities that could potentially dilute net income per share in the future that
were not considered in the diluted net loss per share calculations because the effect would have been anti-dilutive were as follows (in thousands):

Options to purchase common stock
Restricted stock units
ESPP shares issuable

Total

Year Ended December 31,
2022

2023

2021

20,877 
3,086 
249 
24,212 

13,522 
2,694 
166 
16,382 

11,871 
1,602 
207 
13,680 

The number of potential common shares that would have been included in diluted income per share had it not been for the anti-dilutive effect caused by the
net  loss,  computed  by  converting  these  securities  using  the  treasury  stock  method  during  the  years  ended  December  31,  2023,  2022  and  2021,  was
approximately 6.3 million, 0.6 million and 1.1 million, respectively.

20.    COMMITMENTS AND CONTINGENCIES

Guarantees and Indemnifications

We indemnify each of our officers and directors for certain events or occurrences, subject to certain limits, while the officer or director is or was serving at
our  request  in  such  capacity,  as  permitted  under  Delaware  law  and  in  accordance  with  our  certificate  of  incorporation  and  bylaws.  The  term  of  the
indemnification period lasts as long as an officer or director may be subject to any proceeding arising out of acts or omissions of such officer or director in
such capacity.

The maximum amount of potential future indemnification is unlimited; however, we currently hold director and officer liability insurance, which allows the
transfer of risk associated with our exposure and may enable us to recover a portion of any

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future amounts paid. We believe that the fair value of these indemnification obligations is minimal. Accordingly, we have not recognized any liabilities
relating to these obligations for any period presented.

Legal Proceedings and Claims

On  July  30  and  August  12,  2021,  two  putative  securities  class  action  lawsuits  were  commenced  in  the  U.S.  District  Court  for  the  Northern  District  of
California naming as defendants Ardelyx and two current officers captioned Strezsak v. Ardelyx, Inc., et al., Case No. 4:21-cv-05868-HSG, and Siegel v.
Ardelyx, Inc., et al.,  Case  No.  5:21-cv-06228-HSG  (together,  the  Securities  Class  Actions).  The  complaints  allege  that  the  defendants  violated  Sections
10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 thereunder, by making false and misleading statements and omissions
of material fact related to tenapanor. The plaintiffs seek damages and interest, and an award of costs, including attorneys’ fees. On July 19, 2022, the court
consolidated the two putative class actions and appointed a lead plaintiff and lead counsel. The lead plaintiff filed an amended complaint on September 29,
2022. Defendants filed a motion to dismiss the amended complaint on December 2, 2022. In January and February 2023, in lieu of filing a response to
defendant’s motion to dismiss, plaintiffs filed a motion seeking leave to further amend their complaint and defendants filed an opposition to the motion for
leave to further amend the complaint. On April 6, 2023, the court granted plaintiff’s motion for leave to further amend the complaint. With the second
amended complaint, the plaintiffs seek to represent all persons who purchased or otherwise acquired Ardelyx securities between March 6, 2020 and July
19, 2021. Defendants filed a motion to dismiss the amended complaint on June 2, 2023. On August 22, 2023, the court cancelled the hearing scheduled for
September 14, 2023 on the motion to dismiss the amended complaint and indicated its decisions to instead rule on the filed briefs. We believe the plaintiff’s
claims are without merit and we have not recorded any accrual for a contingent liability associated with these legal proceedings.

On December 7, 2021 and March 29, 2022, two verified shareholders derivative lawsuits were filed in the U.S. District Court for the Northern District of
California purportedly on behalf of Ardelyx against certain of Ardelyx’s executive officers and members of our board of directors, captioned Go v. Raab, et
al., Case No. 4:21-cv-09455-HSG, and Morris v. Raab, et al., Case No. 4:22-cv-01988-JSC. The complaints allege that the defendants' violations of Section
14(a) of the Securities Exchange Act of 1934, as amended, breaches of fiduciary duties, unjust enrichment, abuse of control, gross mismanagement, and
waste  of  corporate  assets  for  personally  making  and/or  causing  Ardelyx  to  make  materially  false  and  misleading  statements  regarding  the  Company’s
business,  operations  and  prospects.  The  complaint  seeks  contribution  under  Sections  10(b)  and  21D  of  the  Securities  Exchange  Act  of  1934  from  two
executive  officers.  On  January  19,  and  April  27,  2022,  the  court  granted  the  parties’  stipulation  to  stay  the  Go  and  Morris  actions,  respectively,  until
resolution of the anticipated motion(s) to dismiss in the Securities Class Actions. On October 25, 2022, the parties filed a stipulation to consolidate and stay
the Go and Morris actions, and on October 27, 2022, the court consolidated the Go and Morris action and stayed the consolidated action pending resolution
of the anticipated motion(s) to dismiss in the Securities Class Action. We believe the plaintiff’s claims are without merit and we have not recorded any
accrual for a contingent liability associated with these legal proceedings.

From time to time, we may be involved in legal proceedings arising in the ordinary course of business. As of December 31, 2023, there is no litigation
pending  that  would  reasonably  be  expected  to  have  a  material  adverse  effect  on  our  results  of  operations  and  financial  condition,  and  no  contingent
liabilities were accrued as of December 31, 2023.

ITEM 9.    CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

None.

ITEM 9A.    CONTROLS AND PROCEDURES

Conclusions Regarding the Effectiveness of Disclosure Controls and Procedures

As of December 31, 2023, management, with the participation of our Chief Executive Officer (CEO) and Chief Financial and Operations Officer (CFOO),
performed an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-
15(e) of the Exchange Act. Our disclosure controls and procedures are designed to ensure that information required to be disclosed in the reports we file or
submit  under  the  Exchange  Act  is  recorded,  processed,  summarized  and  reported  within  the  time  periods  specified  in  the  Securities  and  Exchange
Commission’s rules and forms, and that such information is accumulated and communicated to our management, including the CEO and the CFOO, to
allow timely decisions regarding required disclosures.

Any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objective
and management necessarily applies its judgment in evaluating the cost-benefit

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relationship of possible controls and procedures. Based on this evaluation, our CEO and CFOO concluded that, as of December 31, 2023, the design and
operation of our disclosure controls and procedures were effective at a reasonable assurance level.

Management’s Annual Report on Internal Control Over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting. Internal control over financial reporting
is a process designed by, or under the supervision of, our CEO and CFOO, and effected by our Board of Directors, management and other personnel, to
provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance
with generally accepted accounting principles and includes those policies and procedures that:

•

•

•

Pertain  to  the  maintenance  of  records  that  accurately  and  fairly  reflect  in  reasonable  detail  the  transactions  and  dispositions  of  the  assets  of  our
company;

Provide  reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  financial  statements  in  accordance  with  generally
accepted accounting principles, and that our receipts and expenditures are being made only in accordance with authorizations of our management and
directors; and

Provide reasonable assurances regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a
material adverse effect on our financial statements.

Our management assessed our internal control over financial reporting as of December 31, 2023, the end of the period covered by this Annual Report on
Form  10-K.  Management  based  its  assessment  on  criteria  established  in  “Internal  Control—Integrated  Framework  (2013)”  issued  by  the  Committee  of
Sponsoring Organizations of the Treadway Commission. Based on management’s assessment of our internal control over financial reporting, management
concluded that, as of December 31, 2023, our internal control over financial reporting was effective.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) during the
quarter ended December 31, 2023 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Attestation Report of Independent Registered Public Accounting Firm

Our independent registered public accounting firm, Ernst & Young LLP, has audited our Financial Statements included in Item 8 of this Annual Report on
Form 10-K and have issued a report on our internal control over financial reporting as of December 31, 2023. Their report on the audit of internal control
over financial reporting appears below.

Report of Independent Registered Public Accounting Firm

To the Stockholders and the Board of Directors of Ardelyx, Inc.

Opinion on Internal Control Over Financial Reporting

We  have  audited  Ardelyx,  Inc.’s  internal  control  over  financial  reporting  as  of  December  31,  2023,  based  on  criteria  established  in  Internal  Control—
Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) (the COSO criteria). In our
opinion,  Ardelyx,  Inc.  (the  Company)  maintained,  in  all  material  respects,  effective  internal  control  over  financial  reporting  as  of  December  31,  2023,
based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the balance sheets
of Ardelyx, Inc. as of December 31, 2023 and 2022, the related statements of operations and comprehensive loss, stockholders’ equity, and cash flows for
each of the three years in the period ended December 31, 2023, and the related notes, and our report dated February 22, 2024 expressed an unqualified
opinion thereon.

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Basis for Opinion

The Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of
internal control over financial reporting included in the accompanying Management’s Annual Report on Internal Control Over Financial Reporting. Our
responsibility  is  to  express  an  opinion  on  the  Company’s  internal  control  over  financial  reporting  based  on  our  audit.  We  are  a  public  accounting  firm
registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether effective internal control over financial reporting was maintained in all material respects.

Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and
evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered
necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

Definition and Limitations of Internal Control Over Financial Reporting

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting
and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control
over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly
reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit
preparation  of  financial  statements  in  accordance  with  generally  accepted  accounting  principles,  and  that  receipts  and  expenditures  of  the  company  are
being  made  only  in  accordance  with  authorizations  of  management  and  directors  of  the  company;  and  (3)  provide  reasonable  assurance  regarding
prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial
statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of
effectiveness  to  future  periods  are  subject  to  the  risk  that  controls  may  become  inadequate  because  of  changes  in  conditions,  or  that  the  degree  of
compliance with the policies or procedures may deteriorate.

/s/ Ernst & Young LLP

Boston, Massachusetts
February 22, 2024

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ITEM 9B.    OTHER INFORMATION

Trading Plans

During the three months ended December 31, 2023, our Section 16 officers and directors adopted or terminated contracts, instructions or written plans for
the purchase or sale of our securities as noted below:

Date

Action

Adoption

Name and Title of Director or
Officer
Michael Raab, President and Chief
Executive Officer
Elizabeth Grammer, Chief Legal
Officer
Robert Blanks, Chief Regulatory
Officer
Laura Williams, Chief Medical
Officer
December 27, 2023
*Intended to satisfy the affirmative defense conditions of Rule 10b5-1(c)
** Not intended to satisfy the affirmative defense conditions of Rule 10b5-1(c)

December 21, 2023

December 13, 2023

December 20, 2023

Adoption

Adoption

Adoption

Trading Arrangement
Non-Rule
Rule 10b5-
10b5-1**
1*

Total Shares
Available to be
Sold

Expiration Date

X

X

X

X

331,300 

131,000 

48,000 

79,949 

January 6, 2025

July 16, 2024

June 21, 2024

March 27, 2024

ITEM 9C.    DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS

Not Applicable.

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ITEM 10.    DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

PART III

Information required by this item will be contained in our definitive proxy statement to be filed with the Securities and Exchange Commission on Schedule
14A  in  connection  with  our  2024  Annual  Meeting  of  Stockholders  (Proxy  Statement),  which  will  be  filed  not  later  than  120  days  after  the  end  of  our
fiscal  year  ended  December  31,  2023,  under  the  headings  “Executive  Officers,”  “Election  of  Directors,”  “Corporate  Governance,”  and  “
Section 16(a) Beneficial Ownership Reporting Compliance,” and is incorporated herein by reference.

We  have  adopted  a  Code  of  Business  Conduct  and  Ethics  that  applies  to  our  officers,  directors  and  employees  which  is  available  on  our  website  at
www.ardelyx.com.  The  Code  of  Business  Conduct  and  Ethics  is  intended  to  qualify  as  a  “code  of  ethics”  within  the  meaning  of  Section  406  of  the
Sarbanes-Oxley Act of 2002 and Item 406 of Regulation S-K. If we make any amendment to, or waiver from, a provision of our Code of Conduct that we
are required to disclose under SEC rules, we intend to satisfy that disclosure requirement by posting such information to our website at www.ardelyx.com.
The contents of our websites are not intended to be incorporated by reference into this Form 10-K or in any other report or document we file with the SEC,
and any references to our websites are intended to be inactive textual references only.

ITEM 11.    EXECUTIVE COMPENSATION

The information required by this item regarding executive compensation will be incorporated by reference to the information set forth in the sections titled
“Executive Compensation” in our Proxy Statement.

ITEM  12.        SECURITY  OWNERSHIP  OF  CERTAIN  BENEFICIAL  OWNERS  AND  MANAGEMENT  AND  RELATED  STOCKHOLDER

MATTERS

The information required by this item regarding security ownership of certain beneficial owners and management will be incorporated by reference to the
information  set  forth  in  the  section  titled  “Security  Ownership  of  Certain  Beneficial  Owners  and  Management”  and  “Equity  Compensation  Plan
Information” in our Proxy Statement.

ITEM 13.    CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

The information required by this item regarding certain relationships and related transactions and director independence will be incorporated by reference
to the information set forth in the sections titled “Certain Relationships and Related Party Transactions” and “Election of Directors”, respectively, in our
Proxy Statement.

ITEM 14.    PRINCIPAL ACCOUNTANT FEES AND SERVICES

The information required by this item regarding principal accountant fees and services will be incorporated by reference to the information set forth in the
section titled “Principal Accountant Fees and Services” in our Proxy Statement.

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PART IV

ITEM 15.    EXHIBITS, FINANCIAL STATEMENT SCHEDULES

(a) The following documents are filed as part of this report:

1. Financial Statements

See Index to Financial Statements at Item 8 herein.

2. Financial Statement Schedules

All  schedules  are  omitted  because  they  are  not  applicable  or  the  required  information  is  shown  in  the  financial  statements  or  notes

thereto.

3. Exhibits

See the Exhibit Index immediately following this page.

ITEM 16.    FORM 10-K SUMMARY

None.

Exhibit
Number

3.1

3.2

3.3

4.1

4.2

4.3

10.1(a)

10.1(b)

10.2(a)

10.2(b)

10.2(c)

10.2(d)

10.2(e)

10.2(f)

Exhibit Index [IN PROCESS]

Exhibit Description

Amended and Restated Certificate of Incorporation

Certificate of Amendment to Amended and Restated Certificate of
Incorporation

Amended and Restated Bylaws

Reference is made to Exhibits 3.1 and 3.2

Form of Common Stock Certificate

Description of the Registrant’s Securities Registered Pursuant to Section 12 of
the Securities Exchange Act of 1934

Termination Agreement, dated June 2, 2015, by and between AstraZeneca AB
and Ardelyx, Inc.

Amendment No. 1 to Termination Agreement and to Manufacturing and Supply
Agreement, dated November 2, 2015 by and between AstraZeneca AB and
Ardelyx, Inc.

Lease, dated August 8, 2008, by and between 34175 Ardenwood Venture, LLC
and Ardelyx, Inc.

First Amendment to Lease, dated December 20, 2012, by and between 34175
Ardenwood Venture, LLC and Ardelyx, Inc.

Incorporated by Reference

Form

Date

Number

Filed
Herewith

8-K

8-K

8-K

6/24/2014

6/20/2023

6/24/2014

3.1

3.1

3.2

S-1/A

10-K

6/18/2014

3/8/2021

4.2

10.31

10-Q

8/12/2015

10.1

10-K

3/4/2016

10.1(d)

S-1

S-1

5/19/2014

10.4(a)

5/19/2014

10.4(b)

Second Amendment to Lease, dated September 5, 2014, by and between
Ardelyx, Inc. and 34175 Ardenwood Venture, LLC

8-K

9/9/2014

Third Amendment to Lease, dated April 28, 2016, by and between Ardelyx, Inc.
and 34175 Ardenwood Venture, LLC

10-Q

8/8/2016

10.1

10.3

Fourth Amendment to Lease, dated May 25, 2021, by and between
Ardelyx, Inc. and 34175 Ardenwood Venture, LLC

10-K

3/2/2023

10.2(e)

Fifth Amendment to Lease, dated May 25, 2021, by and between Ardelyx, Inc.
and 34175 Ardenwood Venture, LLC

8-K

6/1/2021

10.1

115

 
 
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Exhibit
Number

Exhibit Description

Lease Agreement, dated December 30, 2020, by and between Ardelyx, Inc. and
Prospect Fifth Ave, LLC.

Ardelyx, Inc. 2008 Stock Incentive Plan, as amended

Form of Stock Option Grant Notice and Stock Option Agreement under the
2008 Stock Incentive Plan, as amended

Form of Restricted Stock Purchase Grant Notice and Restricted Stock Purchase
Agreement under the 2008 Stock Incentive Plan, as amended

Ardelyx, Inc. 2014 Equity Incentive Award Plan

Form of Stock Option Grant Notice and Stock Option Agreement under the
2014 Equity Incentive Award Plan

Form of Restricted Stock Award Agreement and Restricted Stock Unit Award
Grant Notice under the 2014 Equity Incentive Award Plan

Ardelyx, Inc. 2014 Employee Stock Purchase Plan

Ardelyx, Inc. 2016 Employment Commencement Incentive Plan

Form of Stock Option Grant Notice and Stock Option Agreement under the
2016 Employment Commencement Incentive Plan

Form of Restricted Stock Unit Award Grant Notice and Restricted Stock Unit
Award Agreement under the 2016 Employment Commencement Incentive Plan

Form of Restricted Stock Award Grant Notice and Restricted Stock Award
Agreement under the 2016 Employment Commencement Incentive Plan

Registration Rights Agreement by and among Ardelyx, Inc. and the investors
signatory thereto, dated June 2, 2015

Registration Rights Agreement by and among Ardelyx, Inc. and the investors
signatory thereto, dated July 14, 2016

Form of Indemnification Agreement for directors and officers

Amended and Restated Executive Employment Agreement, dated June 6, 2014,
by and between Ardelyx, Inc. and Michael Raab

Offer Letter, dated December 28, 2009, by and between Ardelyx, Inc. and
David Rosenbaum, Ph.D.

Second Amended and Restated Change in Control and Severance Agreement by
and between Ardelyx, Inc. and David P. Rosenbaum, Ph.D.

Amendment Number One to Second Amended and Restated Change in Control
Severance Agreement and Retention Agreement dated December 1, 2021
between Ardelyx, Inc. and David Rosenbaum

Offer Letter, dated November 21, 2012, by and between Ardelyx, Inc. and
Elizabeth Grammer, Esq.

10.3

10.4(a)#

10.4(b)#

10.4(c)#

10.5(a)#

10.5(b)#

10.5(c)#

10.6#

10.7(a)#

10.7(b)#

10.7(c)#

10.7(d)#

10.8

10.9

10.10#

10.11#

10.12#

10.13(a)#

10.13(b)#

10.14#

10.15#

10.16#

10.17#

10.18#

10.19#

Second Amended and Restated Change in Control and Severance Agreement by
and between Ardelyx, Inc. and Elizabeth Grammer.

10-Q

5/8/2018

Offer Letter, dated April 27, 2020, by and between Ardelyx, Inc. and Susan
Rodriguez

Change in Control Severance Agreement dated June 2, 2020, by and between
Ardelyx, Inc. and Susan Rodriguez

Offer Letter, dated June 2, 2020, by and between Ardelyx, Inc. and Justin Renz

Change in Control Severance Agreement, dated June 8, 2020, by and between
Ardelyx, Inc. and Justin Renz

10-Q

8/6/2020

10-Q

8/6/2020

10-Q

10-Q

8/6/2020

8/6/2020

10.20(a)#

Second Amended and Restated Non-Employee Director Compensation Program

10-Q

8/4/2022

116

Incorporated by Reference

Form

10-K

Date

3/8/2021

Number

10.31

Filed
Herewith

S-1

S-1

S-1

5/19/2014

5/19/2014

10.5(a)

10.5(b)

5/19/2014

10.5(c)

S-8

S-1/A

7/14/2014

6/9/2014

99.3

10.6(b)

S-1/A

6/9/2014

10.6(c)

7/14/2014

99.6

X

S-8

S-8

S-8

S-8

S-3

11/10/2016

11/10/2016

11/10/2016

7/13/2015

10-Q

8/8/2016

S-1/A

S-1/A

6/9/2014

6/9/2014

S-1/A

6/9/2014

10.13

10-Q

5/8/2018

10.1

10-K

2/28/2022

10.20

S-1/A

6/9/2014

10.14

99.2

99.3

99.4

99.1

10.2

10.7

10.8

10.0

10.1

10.2

10.3

10.4

10.3

 
 
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Exhibit
Number

Exhibit Description

10.20(b)#

Third Amended and Restated Non-Employee Director Compensation Program

10.21(a)††

10.21(b)

10.21(c)††

10.22††

10.23††

10.24(a)

10.24(b)

10.24(c)

10.24(d)

10.25

10.26

License Agreement, dated November 27, 2017, by and between Kyowa Hakko
Kirin Co., Ltd. and Ardelyx, Inc.

Amendment Number 1 to License Agreement, dated as of November 27, 2017,
by and among Ardelyx, Inc., and Kyowa Kirin Co., Ltd.

Amendment Number 2 to License Agreement, dated as of April 11, 2022, by
and among Ardelyx, Inc., and Kyowa Kirin Co., Ltd.

License Agreement, dated December 11, 2017, by and between Shanghai Fosun
Pharmaceutical Industrial Development Co. Ltd. and Ardelyx, Inc.
Royalty and Sales Milestone Interest Acquisition Agreement dated June 29,
2022, by and between Ardelyx, Inc. and Healthcare Royalty Partners IV, L.P.
Loan and Security Agreement dated February 23, 2022, by and between
Ardelyx, Inc. and SLR Investment Corp.
First Amendment to the Loan and Security Agreement dated August 1, 2022, by
and between Ardelyx, Inc. and SLR Investment Corp.
Second Amendment to the Loan and Security Agreement dated February 9,
2023, by and between Ardelyx, Inc. and SLR Investment Corp.
Third Amendment to the Loan and Security Agreement dated October 17, 2023,
by and between Ardelyx, Inc. and SLR Investment Corp.
Exit Fee Agreement dated February 23, 2022, by and between Ardelyx, Inc. and
SLR Investment Corp.
Exit Fee Agreement, dated May 16, 2018, by and between the Company and
Solar Capital Ltd. and Western Alliance Bank.  

Incorporated by Reference

Form

Date

Number

Filed
Herewith

X

10-K

3/14/2018

10.35

10-K

3/2/2023

10.21(c)

8-K

4/11/2022

10.1

10-K

3/14/2018

10.36

10-Q

10-Q

10-Q

10-K

8/4/2022

5/5/2022

8/4/2022

10.1

10.1

10.2

3/2/2023

10.24(c)

8-K

10/18/2023

10-Q

5/5/2022

10-Q

8/7/2018

10.27(a)††

10.27(b)††

Manufacturing Services Agreement, dated May 18, 2020, between Ardelyx, Inc.
and Patheon Pharmaceuticals Inc.

10-Q

8/6/2020

First Amendment to the Manufacturing Services Agreement dated February 27,
2023, between Ardelyx, Inc. and Patheon Pharmaceuticals Inc.

10-K

3/2/2023

10.28

10.29

23.1

31.1

31.2

32.1

Open Market Sales Agreement, dated August 31, 2021 between Ardelyx, Inc.
and Jefferies LLC.

Open Market Sales Agreement, dated January 18, 2023 between Ardelyx, Inc.
and Jefferies LLC.

8-K

8/13/2021

S-3

1/19/2023

Consent of Independent Registered Public Accounting Firm

Certification of Principal Executive Officer Required Under Rule 13a-
14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended

Certification of Principal Financial Officer Required Under Rule 13a-
14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended

Certification of Principal Executive Officer and Principal Financial Officer
Required Under Rule 13a‑14(b) of the Securities Exchange Act of 1934, as
amended, and 18 U.S.C §1350

97.1

101.SCH

101.CAL

101.DEF

101.LAB

101.PRE

Policy for Recovery of Erroneously Awarded Compensation

Inline XBRL Taxonomy Extension Schema Document

Inline XBRL Taxonomy Extension Calculation Linkbase Document

Inline XBRL Taxonomy Extension Definition Linkbase Document

Inline XBRL Taxonomy Extension Label Linkbase Document

Inline XBRL Taxonomy Extension Presentation Linkbase Document

117

10.1

10.2

10.2

10.5

10.3

10.1

1.2

—

—

—

—

—

—

—

—

—

X

X

X

X

X

X

X

X

X

X

 
 
Table of Contents

_______________________________

†    Confidential treatment granted as to portions of this Exhibit. The confidential portions of this Exhibit have been omitted and are marked by asterisks.

††    Certain portions of this exhibit have been redacted pursuant to Item 601(b)(10) of Regulation S-K. A copy of the omitted portions will be furnished

supplementally to the Securities and Exchange Commission upon request.

#    Indicates management contract or compensatory plan.

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Pursuant  to  the  requirements  of  the  Securities  Exchange  Act  of  1934,  the  Registrant  has  duly  caused  this  report  to  be  signed  on  its  behalf  by  the
undersigned, thereunto duly authorized.

SIGNATURES

Date: February 22, 2024

By:

/s/ Robert Felsch

Ardelyx, Inc.

Robert Felsch
Senior Vice President and Chief Accounting Officer
(Principal Accounting Officer)

POWER OF ATTORNEY

Each person whose individual signature appears below hereby authorizes and appoints Michael Raab, Justin Renz, and Robert Felsch, and each of them,
with full power of substitution and resubstitution and full power to act without the other, as his or her true and lawful attorney-in-fact and agent to act in his
or her name, place and stead and to execute in the name and on behalf of each person, individually and in each capacity stated below, and to file any and all
amendments  to  this  annual  report  on  Form  10-K  and  to  file  the  same,  with  all  exhibits  thereto,  and  other  documents  in  connection  therewith,  with  the
Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each
and  every  act  and  thing,  ratifying  and  confirming  all  that  said  attorneys-in-fact  and  agents  or  any  of  them  or  their  or  his  substitute  or  substitutes  may
lawfully do or cause to be done by virtue thereof.

119

 
 
Table of Contents

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant
and in the capacities and on the dates indicated.

Signature

/s/ Michael Raab

Michael Raab

/s/ Justin Renz

Justin Renz

/s/ Robert Felsch

Robert Felsch

/s/ David Mott

David Mott

/s/ Robert Bazemore

Robert Bazemore

/s/ William Bertrand, Jr.

William Bertrand, Jr., J.D.

/s/ Muna Bhanji

Muna Bhanji, R.Ph

/s/ Onaiza Cadoret-Manier

Onaiza Cadoret-Manier

/s/ Jan M. Lundberg

Jan M. Lundberg, Ph.D.

/s/ Richard Rodgers

Richard Rodgers

Title

Date

President, Chief Executive Officer and Director
(Principal Executive Officer)

Chief Financial and Operations Officer
(Principal Financial Officer)

Chief Accounting Officer
(Principal Accounting Officer)

February 22, 2024

February 22, 2024

February 22, 2024

Chairman of the Board of Directors

February 22, 2024

February 22, 2024

February 22, 2024

February 22, 2024

February 22, 2024

February 22, 2024

February 22, 2024

Director

Director

Director

Director

Director

Director

120

Exhibit 10.7(a)

ARDELYX, INC.
2016 EMPLOYMENT COMMENCEMENT INCENTIVE PLAN

ARTICLE 1.

PURPOSE

The purpose of the Ardelyx, Inc. 2016 Employment Commencement Incentive Plan (as it may be amended from time to time, the “Plan”) is to promote the
success and enhance the value of Ardelyx, Inc. (the “Company”) by linking the individual interests of the Eligible Individuals to those of the Company’s
stockholders and by providing such individuals with an incentive for outstanding performance to generate superior returns to the Company’s stockholders.
The Plan is further intended to provide flexibility to the Company in its ability to motivate, attract, and retain the services of Employees upon whose
judgment, interest, and special effort the successful conduct of the Company’s operation is largely dependent. Only Eligible Individuals may receive awards
under the Plan.

ARTICLE 2.

DEFINITIONS AND CONSTRUCTION

Wherever the following terms are used in the Plan they shall have the meanings specified below, unless the context clearly indicates otherwise. The
singular pronoun shall include the plural where the context so indicates.

2.1 “Administrator” shall mean the entity that conducts the general administration of the Plan as provided in Article 12 hereof. With reference to the duties
of the Administrator under the Plan which have been delegated to one or more persons pursuant to Section 12.6 hereof, or as to which the Board has
assumed, the term “Administrator” shall refer to such person(s) unless the Committee or the Board has revoked such delegation or the Board has
terminated the assumption of such duties. For the avoidance of doubt, only the Committee or the Board may grant Awards under the Plan.

2.2 “Affiliate” shall mean any Parent or Subsidiary.

2.3 “Applicable Accounting Standards” shall mean Generally Accepted Accounting Principles in the United States, International Financial Reporting
Standards or such other accounting principles or standards as may apply to the Company’s financial statements under United States federal securities laws
from time to time.

2.4 “Applicable Law” shall mean any applicable law, including without limitation, (i) provisions of the Code, the Securities Act, the Exchange Act and any
rules or regulations thereunder; (ii) corporate, securities, tax or other laws, statutes, rules, requirements or regulations, whether federal, state, local or
foreign; and (iii) rules of any securities exchange or automated quotation system on which the Shares are listed, quoted or traded.

2.5 “Award” shall mean an Option, a Restricted Stock award, a Restricted Stock Unit award, a Performance Award, a Dividend Equivalents award, a
Deferred Stock award, a Deferred Stock Unit award, a Stock Payment award or a Stock Appreciation Right, which may be awarded or granted under the
Plan (collectively, “Awards”).

2.6 “Award Agreement” shall mean any written notice, agreement, terms and conditions, contract or other instrument or document evidencing an Award,
including through electronic medium, which shall contain such terms and conditions with respect to an Award as the Administrator shall determine
consistent with the Plan.

2.7 “Board” shall mean the Board of Directors of the Company.

2.8 “Change in Control” shall mean the occurrence, in a single transaction or in a series of related transactions, of any one or more of the following events:

(a) A transaction or series of transactions (other than an offering of Common Stock to the general public through a registration statement filed with the
Securities and Exchange Commission) whereby any “person” or related “group” of “persons” (as such terms are used in Sections 13(d) and 14(d)(2) of the
Exchange Act) (other than the Company, any of its subsidiaries, an employee benefit plan maintained by the Company or any of its subsidiaries or a
“person” that, prior to such transaction, directly or indirectly controls, is controlled by, or is under common control with, the Company) directly or
indirectly acquires beneficial ownership (within the meaning of Rule 13d-3 under the

Exchange Act) of securities of the Company possessing more than 50% of the total combined voting power of the Company’s securities outstanding
immediately after such acquisition; or

(b) During any period of two consecutive years, individuals who, at the beginning of such period, constitute the Board together with any new Director(s)
(other than a Director designated by a person who shall have entered into an agreement with the Company to effect a transaction described in Section 2.9(a)
or 2.9(c)) whose election by the Board or nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds of the
Directors then still in office who either were Directors at the beginning of the two-year period or whose election or nomination for election was previously
so approved, cease for any reason to constitute a majority thereof; or

(c) The consummation by the Company (whether directly involving the Company or indirectly involving the Company through one or more intermediaries)
of (x) a merger, consolidation, reorganization, or business combination or (y) a sale or other disposition of all or substantially all of the Company’s assets in
any single transaction or series of related transactions or (z) the acquisition of assets or stock of another entity, in each case other than a transaction:

(i) which results in the Company’s voting securities outstanding immediately before the transaction continuing to represent (either by remaining
outstanding or by being converted into voting securities of the Company or the person that, as a result of the transaction, controls, directly or indirectly, the
Company or owns, directly or indirectly, all or substantially all of the Company’s assets or otherwise succeeds to the business of the Company (the
Company or such person, the “Successor Entity”)) directly or indirectly, at least a majority of the combined voting power of the Successor Entity’s
outstanding voting securities immediately after the transaction, and

(ii) after which no person or group beneficially owns voting securities representing 50% or more of the combined voting power of the Successor Entity;
provided, however, that no person or group shall be treated for purposes of this Section 2.9(c)(ii) as beneficially owning 50% or more of the combined
voting power of the Successor Entity solely as a result of the voting power held in the Company prior to the consummation of the transaction; or

(d) The Company’s stockholders approve a liquidation or dissolution of the Company.

Notwithstanding the foregoing, if a Change in Control constitutes a payment event with respect to any portion of an Award that provides for the deferral of
compensation and is subject to Section 409A of the Code, the transaction or event described in subsection (a), (b), (c) or (d) with respect to such Award (or
portion thereof) must also constitute a “change in control event,” as defined in Treasury Regulation Section 1.409A-3(i)(5) to the extent required by Section
409A.

The Committee shall have full and final authority, which shall be exercised in its discretion, to determine conclusively whether a Change in Control of the
Company has occurred pursuant to the above definition, and the date of the occurrence of such Change in Control and any incidental matters relating
thereto; provided that any exercise of authority is in conjunction with a determination of whether a Change in Control is a “change in control event” as
defined in Treasury Regulation Section 1.409A-3(i)(5) shall be consistent with such regulation.

2.9 “Code” shall mean the Internal Revenue Code of 1986, as amended from time to time, together with the regulations and official guidance promulgated
thereunder, whether issued prior or subsequent to the grant of any Award.

2.10 “Committee” shall mean the Compensation Committee of the Board.

2.11 “Common Stock” shall mean the common stock of the Company, par value $0.0001 per share.

2.12 “Company” shall have the meaning set forth in Article 1 hereof.

2.13 “Deferred Stock” shall mean a right to receive Shares awarded under Section 9.4 hereof.

2.14 “Deferred Stock Unit” shall mean a right to receive Shares awarded under Section 9.5 hereof.

2.15 “Director” shall mean a member of the Board, as constituted from time to time.

2.16 “Dividend Equivalent” shall mean a right to receive the equivalent value (in cash or Shares) of dividends paid on Shares, awarded under Section 9.2
hereof.

2.17 “DRO” shall mean a “domestic relations order” as defined by the Code or Title I of the Employee Retirement Income Security Act of 1974, as
amended from time to time, or the rules thereunder.

2.18 “Effective Date” shall mean the date on which the Board has adopted the Plan.

2.19 “Eligible Individual” shall mean any Employee who has not previously been an Employee or Director of the Company or a Subsidiary, or is
commencing employment with the Company or a Subsidiary following a bona fide period of non-employment by the Company or a Subsidiary, if he or she
is granted an Award in connection with his or her commencement of employment with the Company or a Subsidiary and such grant is an inducement
material to his or her entering into employment with the Company or a Subsidiary. The Board may in its discretion adopt procedures from time to time to
ensure that an Employee is eligible to participate in the Plan prior to the granting of any Awards to such Employee under the Plan (including, without
limitation, a requirement, that each such Employee certify to the Company prior to the receipt of an Award under the Plan that he or she has not been
previously employed by the Company or a Subsidiary, or if previously employed, has had a bona fide period of non-employment, and that the grant of
Awards under the Plan is an inducement material to his or her agreement to enter into employment with the Company or a Subsidiary).

2.20 “Employee” shall mean any officer or other employee (as determined in accordance with Section 3401(c) of the Code and the Treasury Regulations
thereunder) of the Company or any Affiliate.

2.21 “Equity Restructuring” shall mean a nonreciprocal transaction between the Company and its stockholders, such as a stock dividend, stock split, spin-
off, rights offering or recapitalization through a large, nonrecurring cash dividend, that affects the number or kind of Shares (or other securities of the
Company) or the share price of Common Stock (or other securities) and causes a change in the per share value of the Common Stock underlying
outstanding stock-based Awards.

2.22 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended from time to time.

2.23 “Fair Market Value” shall mean, as of any given date, the value of a Share determined as follows:

(a) If the Common Stock is (i) listed on any established securities exchange (such as the New York Stock Exchange, the NASDAQ Global Market and the
NASDAQ Global Select Market), (ii) listed on any national market system or (iii) listed, quoted or traded on any automated quotation system, its Fair
Market Value shall be the closing sales price for a Share as quoted on such exchange or system for such date or, if there is no closing sales price for a Share
on the date in question, the closing sales price for a Share on the last preceding date for which such quotation exists, as reported in The Wall Street Journal
or such other source as the Administrator deems reliable;

(b) If the Common Stock is not listed on an established securities exchange, national market system or automated quotation system, but the Common Stock
is regularly quoted by a recognized securities dealer, its Fair Market Value shall be the mean of the high bid and low asked prices for such date or, if there
are no high bid and low asked prices for a Share on such date, the high bid and low asked prices for a Share on the last preceding date for which such
information exists, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; or

(c) If the Common Stock is neither listed on an established securities exchange, national market system or automated quotation system nor regularly quoted
by a recognized securities dealer, its Fair Market Value shall be established by the Administrator in good faith.

2.24 “Holder” shall mean an Eligible Individual who has been granted an Award.

2.25 “Incentive Stock Option” shall mean an Option that is intended to qualify as an incentive stock option and conforms to the applicable provisions of
Section 422 of the Code. Incentive Stock Options may not be granted under the Plan.

2.26 “Non-Employee Director” shall mean a Director of the Company who is not an Employee of the Company and who qualifies as “independent” within
the meaning of Nasdaq Stock Market Rule 5605(a)(2), or any successor rule, if the Company’s securities are traded on the Nasdaq Stock Market, or if the
requirements of any other established stock exchange on which the Company’s securities are traded, as such rules or requirements may be amended from
time to time.

2.27 “Non-Qualified Stock Option” shall mean an Option that is not an Incentive Stock Option.

2.28 “Option” shall mean a right to purchase Shares at a specified exercise price, granted under Article 5 hereof. Any Option granted under this Plan shall
be a Non-Qualified Stock Option.

2.29 “Option Term” shall have the meaning set forth in Section 5.4 hereof.

2.30 “Parent” shall mean any entity (other than the Company), whether domestic or foreign, in an unbroken chain of entities ending with the Company if
each of the entities other than the Company beneficially owns, at the time of the determination, securities or interests representing more than fifty percent
(50%) of the total combined voting power of all classes of securities or interests in one of the other entities in such chain.

2.31 “Performance Award” shall mean a cash bonus award, stock bonus award, performance award or incentive award that is paid in cash, Shares or a
combination of both, awarded under Section 9.1 hereof.

2.32 “Performance Stock Unit” shall mean a Performance Award awarded under Section 9.1 hereof which is denominated in units of value including dollar
value of shares of Common Stock.

2.33 “Permitted Transferee” shall mean, with respect to a Holder, any “family member” of the Holder, as defined under the General Instructions to Form S-
8 Registration Statement under the Securities Act or any successor Form thereto, or any other transferee specifically approved by the Administrator, after
taking into account Applicable Law.

2.34 “Plan” shall have the meaning set forth in Article 1 hereof.

2.35 “Program” shall mean any program adopted by the Administrator pursuant to the Plan containing the terms and conditions intended to govern a
specified type of Award granted under the Plan and pursuant to which such type of Award may be granted under the Plan.

2.36 “Restricted Stock” shall mean an award of Shares made under Article 7 hereof that is subject to certain restrictions and may be subject to risk of
forfeiture or repurchase.

2.37 “Restricted Stock Unit” shall mean a contractual right awarded under Article 8 hereof to receive in the future a Share or the Fair Market Value of a
Share in cash.

2.38 “Securities Act” shall mean the Securities Act of 1933, as amended.

2.39 “Shares” shall mean shares of Common Stock.

2.40 “Share Limit” shall have the meaning set forth in Section 3.1(a) hereof.

2.41 “Stock Appreciation Right” shall mean a stock appreciation right granted under Article 10 hereof.

2.42 “Stock Appreciation Right Term” shall have the meaning set forth in Section 10.4 hereof.

2.43 “Stock Payment” shall mean (a) a payment in the form of Shares, or (b) an option or other right to purchase Shares, as part of a bonus, deferred
compensation or other arrangement, awarded under Section 9.3 hereof.

2.44 “Subsidiary” shall mean any entity (other than the Company), whether domestic or foreign, in an unbroken chain of entities beginning with the
Company if each of the entities other than the last entity in the unbroken chain beneficially owns, at the time of the determination, securities or interests
representing more than fifty percent (50%) of the total combined voting power of all classes of securities or interests in one of the other entities in such
chain.

2.45 “Substitute Award” shall mean an Award granted under the Plan upon the assumption of, or in substitution for, outstanding equity awards previously
granted by a company or other entity in connection with a corporate transaction, such as a merger, combination, consolidation or acquisition of property or
stock; provided, however, that in no event shall the term “Substitute Award” be construed to refer to an award made in connection with the cancellation and
repricing of an Option or Stock Appreciation Right.

2.46 “Termination of Service” shall mean the time when the employee-employer relationship between a Holder and the Company or any Affiliate is
terminated for any reason, including, without limitation, a termination by resignation, discharge, death, disability or retirement; but excluding terminations
where the Holder simultaneously commences or remains in employment or service with the Company or any Affiliate.

The Administrator, in its sole discretion, shall determine the effect of all matters and questions relating to Terminations of Service, including, without
limitation, the question of whether a Termination of Service resulted from a discharge for cause and all questions of whether particular leaves of absence
constitute a Termination of Service. For purposes of the Plan, a Holder’s employee-employer relationship or consultancy relations shall be deemed to be
terminated in the event that the Affiliate employing or contracting with such Holder ceases to remain an Affiliate following any merger, sale of stock or
other corporate transaction or event (including, without limitation, a spin-off).

ARTICLE 3.

SHARES SUBJECT TO THE PLAN

3.1 Number of Shares.

(a) Subject to Sections 13.1, 13.2 and 3.1(b) hereof, the aggregate number of Shares which may be issued or transferred pursuant to Awards under the Plan
shall be 12,207,767 Shares (the “Share Limit”). Notwithstanding the foregoing, to the extent permitted under Applicable Law, Awards that provide for the
delivery of Shares subsequent to the applicable grant date may be granted in excess of the Share Limit if such Awards provide for the forfeiture or cash
settlement of such Awards to the extent that insufficient Shares remain under the Share Limit in this Section 3.1 at the time that Shares would otherwise be
issued in respect of such Award.

(b) If any Shares subject to an Award are forfeited or expire or such Award is settled for cash (in whole or in part), the Shares subject to such Award shall,
to the extent of such forfeiture, expiration or cash settlement, again be available for future grants of Awards under the Plan and shall be added back to the
Share Limit. In addition, the following Shares shall be available for future grants of Awards under the Plan and shall be added back to the Share Limit: (i)
Shares tendered by a Holder or withheld by the Company in payment of the exercise price of an Option; (ii) Shares tendered by the Holder or withheld by
the Company to satisfy any tax withholding obligation with respect to an Award; and (iii) Shares subject to Stock Appreciation Rights that are not issued in
connection with the stock settlement of the Stock Appreciation Rights on exercise thereof. Any Shares repurchased by the Company under Section 7.4
hereof at the same price paid by the Holder or a lower price so that such Shares are returned to the Company will again be available for Awards. The
payment of Dividend Equivalents in cash in conjunction with any outstanding Awards shall not be counted against the Shares available for issuance under
the Plan.

(c) Substitute Awards shall not reduce the Shares authorized for grant under the Plan. Additionally, in the event that a company acquired by the Company
or any Affiliate or with which the Company or any Affiliate combines has shares available under a pre-existing plan approved by its stockholders and not
adopted in contemplation of such acquisition or combination, the shares available for grant pursuant to the terms of such pre-existing plan (as adjusted, to
the extent appropriate, using the exchange ratio or other adjustment or valuation ratio or formula used in such acquisition or combination to determine the
consideration payable to the holders of common stock of the entities party to such acquisition or combination) may be used for Awards under the Plan and
shall not reduce the Shares authorized for grant under the Plan; provided that Awards using such available shares shall not be made after the date awards or
grants could have been made under the terms of the pre-existing plan, absent the acquisition or combination, and shall only be made to individuals who
were not employed by or providing services to the Company or its Affiliates immediately prior to such acquisition or combination.

3.2 Stock Distributed. Any Shares distributed pursuant to an Award may consist, in whole or in part, of authorized and unissued Common Stock, treasury
Common Stock or Common Stock purchased on the open market.

ARTICLE 4.

GRANTING OF AWARDS

4.1 Participation. The Committee and the Board may, from time to time, select from among all Eligible Individuals, those to whom an Award shall be
granted and shall determine the nature and amount of each Award, which shall not be inconsistent with the requirements of the Plan. No Eligible Individual
shall have any right to be granted an Award pursuant to the Plan.

4.2 Award Agreement. Each Award shall be evidenced by an Award Agreement that sets forth the terms, conditions and limitations for such Award, which
may include the term of the Award, the provisions applicable in the event of

the Holder’s Termination of Service, and the Company’s authority to unilaterally or bilaterally amend, modify, suspend, cancel or rescind an Award.

4.3 Limitations Applicable to Section 16 Persons. Notwithstanding any other provision of the Plan, the Plan, and any Award granted or awarded to any
individual who is then subject to Section 16 of the Exchange Act, shall be subject to any additional limitations set forth in any applicable exemptive rule
under Section 16 of the Exchange Act (including Rule 16b-3 of the Exchange Act and any amendments thereto) that are requirements for the application of
such exemptive rule. To the extent permitted by Applicable Law, the Plan and Awards granted or awarded hereunder shall be deemed amended to the extent
necessary to conform to such applicable exemptive rule.

4.4 At-Will Employment; Voluntary Participation. Nothing in the Plan or in any Program or Award Agreement hereunder shall confer upon any Holder any
right to continue in the employ of the Company or any Affiliate, or shall interfere with or restrict in any way the rights of the Company and any Affiliate,
which rights are hereby expressly reserved, to discharge any Holder at any time for any reason whatsoever, with or without cause, and with or without
notice, or to terminate or change all other terms and conditions of employment, except to the extent expressly provided otherwise in a written agreement
between the Holder and the Company or any Affiliate. Participation by each Holder in the Plan shall be voluntary and nothing in the Plan shall be
construed as mandating that any Eligible Individual shall participate in the Plan.

4.5 Foreign Holders. Notwithstanding any provision of the Plan to the contrary, in order to comply with the laws in countries other than the United States in
which the Company and its Affiliates operate or have Employees, or in order to comply with the requirements of any foreign securities exchange, the
Administrator, in its sole discretion, shall have the power and authority to: (a) determine which Affiliates shall be covered by the Plan; (b) determine which
Eligible Individuals outside the United States are eligible to participate in the Plan; (c) modify the terms and conditions of any Award granted to Eligible
Individuals outside the United States to comply with applicable foreign laws or listing requirements of any such foreign securities exchange; (d) establish
subplans and modify exercise procedures and other terms and procedures, to the extent such actions may be necessary or advisable (any such subplans
and/or modifications shall be attached to the Plan as appendices); provided, however, that no such subplans and/or modifications shall increase the share
limitations contained in Section 3.1 hereof; and (e) take any action, before or after an Award is made, that it deems advisable to obtain approval or comply
with any necessary local governmental regulatory exemptions or approvals or listing requirements of any such foreign securities exchange.
Notwithstanding the foregoing, the Administrator may not take any actions hereunder, and no Awards shall be granted, that would violate the Code, the
Exchange Act, the Securities Act, any other securities law or governing statute, the rules of the securities exchange or automated quotation system on
which the Shares are listed, quoted or traded or any other Applicable Law. For purposes of the Plan, all references to foreign laws, rules, regulations or
taxes shall be references to the laws, rules, regulations and taxes of any applicable jurisdiction other than the United States or a political subdivision
thereof.

4.6 Stand-Alone and Tandem Awards. Awards granted pursuant to the Plan may, in the sole discretion of the Administrator, be granted either alone, in
addition to, or in tandem with, any other Award granted pursuant to the Plan. Awards granted in addition to or in tandem with other Awards may be granted
either at the same time as or at a different time from the grant of such other Awards.

ARTICLE 5.

GRANTING OF OPTIONS

5.1 Granting of Options to Eligible Individuals. Each of the Committee and the Board is authorized to grant Options to Eligible Individuals from time to
time, in its sole discretion, on such terms and conditions as it may determine which shall not be inconsistent with the Plan.

5.2 Option Exercise Price. Except as provided in Article 13 hereof, the exercise price per Share subject to each Option shall be set by the Committee or the
Board, but shall not be less than one hundred percent (100%) of the Fair Market Value of a Share on the date the Option is granted.

5.3 Option Term. The term of each Option (the “Option Term”) shall be set by the Administrator in its sole discretion; provided, however, that the Option
Term shall not be more than ten (10) years from the date the Option is granted. The Administrator shall determine the time period, including the time period
following a Termination of Service, during which the Holder has the right to exercise the vested Options, which time period may not extend beyond the last
day of the Option Term. Except as limited by the requirements of Section 409A of the Code or the first sentence of this Section 5.3, the Administrator may
extend the Option Term of any outstanding Option, may

extend the time period during which vested Options may be exercised following any Termination of Service of the Holder, and may amend any other term
or condition of such Option relating to such a Termination of Service.

5.4 Option Vesting.

(a) The period during which the right to exercise, in whole or in part, an Option vests in the Holder shall be set by the Administrator and the Administrator
may determine that an Option may not be exercised in whole or in part for a specified period after it is granted. Such vesting may be based on service with
the Company or any Affiliate, any performance criteria, or any other criteria selected by the Administrator. At any time after the grant of an Option, the
Administrator may, in its sole discretion and subject to whatever terms and conditions it selects, accelerate the vesting of the Option, including following a
Termination of Service; provided, that in no event shall an Option become exercisable following its expiration, termination or forfeiture.

(b) No portion of an Option which is unexercisable at a Holder’s Termination of Service shall thereafter become exercisable, except as may be otherwise
provided by the Administrator either in the Program, the Award Agreement or by action of the Administrator following the grant of the Option.

5.5 Substitute Awards. Notwithstanding the foregoing provisions of this Article 5 to the contrary, in the case of an Option that is a Substitute Award, the
price per share of the shares subject to such Option may be less than the Fair Market Value per share on the date of grant; provided that the excess of: (a)
the aggregate Fair Market Value (as of the date such Substitute Award is granted) of the shares subject to the Substitute Award, over (b) the aggregate
exercise price thereof does not exceed the excess of: (x) the aggregate fair market value (as of the time immediately preceding the transaction giving rise to
the Substitute Award, such fair market value to be determined by the Administrator) of the shares of the predecessor entity that were subject to the grant
assumed or substituted for by the Company, over (y) the aggregate exercise price of such shares.

5.6 Substitution of Stock Appreciation Rights. The Administrator may provide in the applicable Program or the Award Agreement evidencing the grant of
an Option that the Administrator, in its sole discretion, shall have the right to substitute a Stock Appreciation Right for such Option at any time prior to or
upon exercise of such Option; provided that such Stock Appreciation Right shall be exercisable with respect to the same number of Shares for which such
substituted Option would have been exercisable, and shall also have the same exercise price, vesting schedule and remaining Option Term as the substituted
Option.

ARTICLE 6.

EXERCISE OF OPTIONS

6.1 Partial Exercise. An exercisable Option may be exercised in whole or in part. However, an Option shall not be exercisable with respect to fractional
Shares and the Administrator may require that, by the terms of the Option, a partial exercise must be with respect to a minimum number of Shares.

6.2 Manner of Exercise. All or a portion of an exercisable Option shall be deemed exercised upon delivery of all of the following to the Secretary of the
Company, or such other person or entity designated by the Administrator, or his, her or its office, as applicable:

(a) A written or electronic notice complying with the applicable rules established by the Administrator stating that the Option, or a portion thereof, is
exercised. The notice shall be signed by the Holder or other person then entitled to exercise the Option or such portion of the Option;

(b) Such representations and documents as the Administrator, in its sole discretion, deems necessary or advisable to effect compliance with all Applicable
Law. The Administrator may, in its sole discretion, also take whatever additional actions it deems appropriate to effect such compliance including, without
limitation, placing legends on share certificates and issuing stop-transfer notices to agents and registrars;

(c) In the event that the Option shall be exercised pursuant to Section 11.3 hereof by any person or persons other than the Holder, appropriate proof of the
right of such person or persons to exercise the Option, as determined in the sole discretion of the Administrator; and

(d) Full payment of the exercise price and applicable withholding taxes to the stock administrator of the Company for the shares with respect to which the
Option, or portion thereof, is exercised, in a manner permitted by Section 11.1 and 11.2 hereof.

ARTICLE 7.

AWARD OF RESTRICTED STOCK

7.1 Award of Restricted Stock.

(a) Each of the Committee and the Board is authorized to grant Restricted Stock to Eligible Individuals, and shall determine the terms and conditions,
including the restrictions applicable to each award of Restricted Stock, which terms and conditions shall not be inconsistent with the Plan, and may impose
such conditions on the issuance of such Restricted Stock as it deems appropriate.

(b) The Administrator shall establish the purchase price, if any, and form of payment for Restricted Stock; provided, however, that if a purchase price is
charged, such purchase price shall be no less than the par value, if any, of the Shares to be purchased, unless otherwise permitted by Applicable Law. In all
cases, legal consideration shall be required for each issuance of Restricted Stock to the extent required by Applicable Law.

7.2 Rights as Stockholders. Subject to Section 7.4 hereof, upon issuance of Restricted Stock, the Holder shall have, unless otherwise provided by the
Administrator, all the rights of a stockholder with respect to said Shares, subject to the restrictions in the applicable Program or in each individual Award
Agreement, including the right to receive all dividends and other distributions paid or made with respect to the Shares; provided, however, that, in the sole
discretion of the Administrator, any extraordinary distributions with respect to the Shares shall be subject to the restrictions set forth in Section 7.3 hereof.

7.3 Restrictions. All shares of Restricted Stock (including any shares received by Holders thereof with respect to shares of Restricted Stock as a result of
stock dividends, stock splits or any other form of recapitalization) shall, in the terms of the applicable Program or in each individual Award Agreement, be
subject to such restrictions and vesting requirements as the Administrator shall provide. Such restrictions may include, without limitation, restrictions
concerning voting rights and transferability and such restrictions may lapse separately or in combination at such times and pursuant to such circumstances
or based on such criteria as selected by the Administrator, including, without limitation, criteria based on the Holder’s duration of employment with the
Company, Company or Affiliate performance, individual performance or other criteria selected by the Administrator. By action taken after the Restricted
Stock is issued, the Administrator may, on such terms and conditions as it may determine to be appropriate, accelerate the vesting of such Restricted Stock
by removing any or all of the restrictions imposed by the terms of the Program and/or the Award Agreement. Restricted Stock may not be sold or
encumbered until all restrictions are terminated or expire.

7.4 Repurchase or Forfeiture of Restricted Stock. Except as otherwise determined by the Administrator at the time of the grant of the Award or thereafter, if
no price was paid by the Holder for the Restricted Stock, upon a Termination of Service during the applicable restriction period, the Holder’s rights in
unvested Restricted Stock then subject to restrictions shall lapse, and such Restricted Stock shall be surrendered to the Company and cancelled without
consideration. If a price was paid by the Holder for the Restricted Stock, upon a Termination of Service during the applicable restriction period, the
Company shall have the right to repurchase from the Holder the unvested Restricted Stock then subject to restrictions at a cash price per share equal to the
price paid by the Holder for such Restricted Stock or such other amount as may be specified in the Program or the Award Agreement. Notwithstanding the
foregoing, the Administrator in its sole discretion may provide that in the event of certain events, including a Change in Control, the Holder’s death,
retirement or disability or any other specified Termination of Service or any other event, the Holder’s rights in unvested Restricted Stock shall not lapse,
such Restricted Stock shall vest and, if applicable, the Company shall not have a right of repurchase.

7.5 Certificates for Restricted Stock. Restricted Stock granted pursuant to the Plan may be evidenced in such manner as the Administrator shall determine.
Certificates or book entries evidencing shares of Restricted Stock must include an appropriate legend referring to the terms, conditions, and restrictions
applicable to such Restricted Stock. The Company may, in its sole discretion, (a) retain physical possession of any stock certificate evidencing shares of
Restricted Stock until the restrictions thereon shall have lapsed and/or (b) require that the stock certificates evidencing shares of Restricted Stock be held in
custody by a designated escrow agent (which may but need not be the Company) until the restrictions thereon shall have lapsed, and that the Holder deliver
a stock power, endorsed in blank, relating to such Restricted Stock.

7.6 Section 83(b) Election. If a Holder makes an election under Section 83(b) of the Code to be taxed with respect to the Restricted Stock as of the date of
transfer of the Restricted Stock rather than as of the date or dates upon which the Holder would otherwise be taxable under Section 83(a) of the Code, the
Holder shall be required to deliver a copy of such election to the Company promptly after filing such election with the Internal Revenue Service.

ARTICLE 8.
AWARD OF RESTRICTED STOCK UNITS

8.1 Grant of Restricted Stock Units. Each of the Committee and the Board is authorized to grant Awards of Restricted Stock Units to any Eligible
Individual selected by the Administrator in such amounts and subject to such terms and conditions as determined by the Administrator.

8.2 Term. Except as otherwise provided herein, the term of a Restricted Stock Unit award shall be set by the Administrator in its sole discretion.

8.3 Purchase Price. The Administrator shall specify the purchase price, if any, to be paid by the Holder to the Company with respect to any Restricted Stock
Unit award; provided, however, that value of the consideration shall not be less than the par value of a Share, unless otherwise permitted by Applicable
Law.

8.4 Vesting of Restricted Stock Units. At the time of grant, the Administrator shall specify the date or dates on which the Restricted Stock Units shall
become fully vested and nonforfeitable, and may specify such conditions to vesting as it deems appropriate, including, without limitation, vesting based
upon the Holder’s duration of service to the Company or any Affiliate, Company performance, individual performance or other specific criteria, in each
case on a specified date or dates or over any period or periods, as determined by the Administrator.

8.5 Maturity and Payment. At the time of grant, the Administrator shall specify the maturity date applicable to each grant of Restricted Stock Units which
shall be no earlier than the vesting date or dates of the Award and may be determined at the election of the Holder (if permitted by the applicable Award
Agreement); provided that, except as otherwise determined by the Administrator, set forth in any applicable Award Agreement, and subject to compliance
with Section 409A of the Code, in no event shall the maturity date relating to each Restricted Stock Unit occur following the later of (a) the fifteenth (15th)
day of the third (3rd) month following the end of calendar year in which the Restricted Stock Unit vests; or (b) the fifteenth (15th) day of the third (3rd)
month following the end of the Company’s fiscal year in which the Restricted Stock Unit vests. On the maturity date, the Company shall, subject to Section
11.4(e) hereof, transfer to the Holder one unrestricted, fully transferable Share for each Restricted Stock Unit scheduled to be paid out on such date and not
previously forfeited, or, in the sole discretion of the Administrator, an amount in cash equal to the Fair Market Value of such shares on the maturity date or
a combination of cash and Common Stock as determined by the Administrator.

8.6 Payment upon Termination of Service. An Award of Restricted Stock Units shall only be payable while the Holder is an Employee; provided, however,
that the Administrator, in its sole and absolute discretion may provide (in an Award Agreement or otherwise) that a Restricted Stock Unit award may be
paid subsequent to a Termination of Service in certain events, including a Change in Control, the Holder’s death, retirement or disability or any other
specified Termination of Service.

8.7 No Rights as a Stockholder. Unless otherwise determined by the Administrator, a Holder who is awarded Restricted Stock Units shall possess no
incidents of ownership with respect to the Shares represented by such Restricted Stock Units, unless and until the same are transferred to the Holder
pursuant to the terms of this Plan and the Award Agreement.

8.8 Dividend Equivalents. Subject to Section 9.2 hereof, the Administrator may, in its sole discretion, provide that Dividend Equivalents shall be earned by
a Holder of Restricted Stock Units based on dividends declared on the Common Stock, to be credited as of dividend payment dates during the period
between the date an Award of Restricted Stock Units is granted to a Holder and the maturity date of such Award.

ARTICLE 9.

AWARD OF PERFORMANCE AWARDS, DIVIDEND EQUIVALENTS, STOCK
PAYMENTS, DEFERRED STOCK, DEFERRED STOCK UNITS

9.1 Performance Awards.

(a) Each of the Board and the Committee is authorized to grant Performance Awards, including Awards of Performance Stock Units, to any Eligible
Individual. The value of Performance Awards, including Performance Stock Units, may be linked to any performance criteria or other specific criteria
determined by the Administrator, in each case on a specified date or dates or over any period or periods determined by the Administrator. Performance
Awards, including Performance Stock Unit awards may be paid in cash, Shares, or a combination of cash and Shares, as determined by the Administrator.

(b) Without limiting Section 9.1(a) hereof, each of the Board and the Committee may grant Performance Awards to any Eligible Individual in the form of a
cash bonus payable upon the attainment of objective performance criteria, or such other criteria, whether or not objective, which are established by the
Administrator, in each case on a specified date or dates or over any period or periods determined by the Administrator.

9.2 Dividend Equivalents.

(a) Dividend Equivalents may be granted by each of the Board and the Committee based on dividends declared on the Common Stock, to be credited as of
dividend payment dates during the period between the date an Award is granted to a Holder and the date such Award vests, is exercised, is distributed or
expires, as determined by the Administrator. Such Dividend Equivalents shall be converted to cash or additional shares of Common Stock by such formula
and at such time and subject to such limitations as may be determined by the Administrator.

(b) Notwithstanding the foregoing, no Dividend Equivalents shall be payable with respect to Options or Stock Appreciation Rights.

9.3 Stock Payments. Each of the Board and the Committee is authorized to make Stock Payments to any Eligible Individual. The number or value of Shares
of any Stock Payment shall be determined by the Administrator and may be based upon performance criteria or any other specific criteria, including service
to the Company or any Affiliate, determined by the Administrator. Shares underlying a Stock Payment which is subject to a vesting schedule or other
conditions or criteria set by the Administrator will not be issued until those conditions have been satisfied. Unless otherwise provided by the Administrator,
a Holder of a Stock Payment shall have no rights as a Company stockholder with respect to such Stock Payment until such time as the Stock Payment has
vested and the Shares underlying the Award have been issued to the Holder. Stock Payments may, but are not required to, be made in lieu of base salary,
bonus, fees or other cash compensation otherwise payable to such Eligible Individual.

9.4 Deferred Stock. Each of the Board and the Committee is authorized to grant Deferred Stock to any Eligible Individual. The number of shares of
Deferred Stock shall be determined by the Administrator and may (but is not required to) be based on performance criteria or other specific criteria,
including service to the Company or any Affiliate, as the Administrator determines, in each case on a specified date or dates or over any period or periods
determined by the Administrator. Shares underlying a Deferred Stock award which is subject to a vesting schedule or other conditions or criteria set by the
Administrator will be issued on the vesting date(s) or date(s) that those conditions and criteria have been satisfied, as applicable. Unless otherwise provided
by the Administrator, a Holder of Deferred Stock shall have no rights as a Company stockholder with respect to such Deferred Stock until such time as the
Award has vested and any other applicable conditions and/or criteria have been satisfied and the Shares underlying the Award have been issued to the
Holder.

9.5 Deferred Stock Units. Each of the Board and the Committee is authorized to grant Deferred Stock Units to any Eligible Individual. The number of
Deferred Stock Units shall be determined by the Administrator and may (but is not required to) be based on performance criteria or other specific criteria,
including service to the Company or any Affiliate, as the Administrator determines, in each case on a specified date or dates or over any period or periods
determined by the Administrator. Each Deferred Stock Unit shall entitle the Holder thereof to receive one share of Common Stock on the date the Deferred
Stock Unit becomes vested or upon a specified settlement date thereafter (which settlement date may (but is not required to) be the date of the Holder’s
Termination of Service). Shares underlying a Deferred Stock Unit award which is subject to a vesting schedule or other conditions or criteria set by the
Administrator will not be issued until on or following the date that those conditions and criteria have been satisfied. Unless otherwise provided by the
Administrator, a Holder of Deferred Stock Units shall have no rights as a Company stockholder with respect to such Deferred Stock Units until such time
as the Award has vested and any

other applicable conditions and/or criteria have been satisfied and the Shares underlying the Award have been issued to the Holder.

9.6 Term. The term of a Performance Award, Dividend Equivalent award, Stock Payment award, Deferred Stock award and/or Deferred Stock Unit award
shall be set by the Administrator in its sole discretion.

9.7 Purchase Price. The Administrator may establish the purchase price of a Performance Award, Shares distributed as a Stock Payment award, shares of
Deferred Stock or Shares distributed pursuant to a Deferred Stock Unit award; provided, however, that value of the consideration shall not be less than the
par value of a Share, unless otherwise permitted by Applicable Law.

9.8 Termination of Service. A Performance Award, Stock Payment award, Dividend Equivalent award, Deferred Stock award and/or Deferred Stock Unit
award is distributable only while the Holder is an Employee. The Administrator, however, in its sole discretion may provide that the Performance Award,
Dividend Equivalent award, Stock Payment award, Deferred Stock award and/or Deferred Stock Unit award may be distributed subsequent to a
Termination of Service in certain events, including a Change in Control, the Holder’s death, retirement or disability or any other specified Termination of
Service.

ARTICLE 10.

AWARD OF STOCK APPRECIATION RIGHTS

10.1 Grant of Stock Appreciation Rights.

(a) Each of the Board and the Committee is authorized to grant Stock Appreciation Rights to Eligible Individuals from time to time, in its sole discretion,
on such terms and conditions as it may determine consistent with the Plan.

(b) A Stock Appreciation Right shall entitle the Holder (or other person entitled to exercise the Stock Appreciation Right pursuant to the Plan) to exercise
all or a specified portion of the Stock Appreciation Right (to the extent then exercisable pursuant to its terms) and to receive from the Company an amount
determined by multiplying the difference obtained by subtracting the exercise price per Share of the Stock Appreciation Right from the Fair Market Value
on the date of exercise of the Stock Appreciation Right by the number of Shares with respect to which the Stock Appreciation Right shall have been
exercised, subject to any limitations the Administrator may impose. Except as described in (c) below or in Section 13.2 hereof, the exercise price per Share
subject to each Stock Appreciation Right shall be set by the Administrator, but shall not be less than one hundred percent (100%) of the Fair Market Value
on the date the Stock Appreciation Right is granted.

(c) Notwithstanding the foregoing provisions of Section 10.1(b) hereof to the contrary, in the case of a Stock Appreciation Right that is a Substitute Award,
the price per Share of the Shares subject to such Stock Appreciation Right may be less than one hundred percent (100%) of the Fair Market Value per share
on the date of grant; provided that the excess of: (i) the aggregate Fair Market Value (as of the date such Substitute Award is granted) of the shares subject
to the Substitute Award, over (ii) the aggregate exercise price thereof does not exceed the excess of: (x) the aggregate fair market value (as of the time
immediately preceding the transaction giving rise to the Substitute Award, such fair market value to be determined by the Administrator) of the shares of
the predecessor entity that were subject to the grant assumed or substituted for by the Company, over (y) the aggregate exercise price of such shares.

10.2 Stock Appreciation Right Vesting.

(a) The period during which the right to exercise, in whole or in part, a Stock Appreciation Right vests in the Holder shall be set by the Administrator and
the Administrator may determine that a Stock Appreciation Right may not be exercised in whole or in part for a specified period after it is granted. Such
vesting may be based on service with the Company or any Affiliate, any performance criteria or any other criteria selected by the Administrator. At any
time after grant of a Stock Appreciation Right, the Administrator may, in its sole discretion and subject to whatever terms and conditions it selects,
accelerate the period during which a Stock Appreciation Right vests.

(b) No portion of a Stock Appreciation Right which is unexercisable at Termination of Service shall thereafter become exercisable, except as may be
otherwise provided by the Administrator either in the applicable Program or Award Agreement or by action of the Administrator following the grant of the
Stock Appreciation Right, including following a Termination of Service; provided, that in no event shall a Stock Appreciation Right become exercisable
following its expiration, termination or forfeiture.

10.3 Manner of Exercise. All or a portion of an exercisable Stock Appreciation Right shall be deemed exercised upon delivery of all of the following to the
stock administrator of the Company, or such other person or entity designated by the Administrator, or his, her or its office, as applicable:

(a) A written or electronic notice complying with the applicable rules established by the Administrator stating that the Stock Appreciation Right, or a
portion thereof, is exercised. The notice shall be signed by the Holder or other person then entitled to exercise the Stock Appreciation Right or such portion
of the Stock Appreciation Right;

(b) Such representations and documents as the Administrator, in its sole discretion, deems necessary or advisable to effect compliance with all applicable
provisions of the Securities Act and any other federal, state or foreign securities laws or regulations. The Administrator may, in its sole discretion, also take
whatever additional actions it deems appropriate to effect such compliance; and

(c) In the event that the Stock Appreciation Right shall be exercised pursuant to this Section 10.3 hereof by any person or persons other than the Holder,
appropriate proof of the right of such person or persons to exercise the Stock Appreciation Right.

10.4 Stock Appreciation Right Term. The term of each Stock Appreciation Right (the “Stock Appreciation Right Term”) shall be set by the Administrator
in its sole discretion; provided, however, that the term shall not be more than ten (10) years from the date the Stock Appreciation Right is granted. The
Administrator shall determine the time period, including the time period following a Termination of Service, during which the Holder has the right to
exercise the vested Stock Appreciation Rights, which time period may not extend beyond the expiration date of the Stock Appreciation Right Term. Except
as limited by the requirements of Section 409A of the Code and regulations and rulings thereunder or the first sentence of this Section 10.4, the
Administrator may extend the Stock Appreciation Right Term of any outstanding Stock Appreciation Right, may extend the time period during which
vested Stock Appreciation Rights may be exercised following any Termination of Service of the Holder, and may amend any other term or condition of
such Stock Appreciation Right relating to such a Termination of Service.

10.5 Payment. Payment of the amounts payable with respect to Stock Appreciation Rights pursuant to this Article 10 shall be in cash, Shares (based on its
Fair Market Value as of the date the Stock Appreciation Right is exercised), or a combination of both, as determined by the Administrator.

ARTICLE 11.

ADDITIONAL TERMS OF AWARDS

11.1 Payment. The Administrator shall determine the methods by which payments by any Holder with respect to any Awards granted under the Plan shall
be made, including, without limitation: (a) cash or check, (b) Shares (including, in the case of payment of the exercise price of an Award, Shares issuable
pursuant to the exercise of the Award) or Shares held for such period of time as may be required by the Administrator in order to avoid adverse accounting
consequences, in each case, having a Fair Market Value on the date of delivery equal to the aggregate payments required, (c) delivery of a written or
electronic notice that the Holder has placed a market sell order with a broker with respect to Shares then issuable upon exercise or vesting of an Award, and
that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the aggregate payments
required; provided that payment of such proceeds is then made to the Company upon settlement of such sale, or (d) other form of legal consideration
acceptable to the Administrator. The Administrator shall also determine the methods by which Shares shall be delivered or deemed to be delivered to
Holders. Notwithstanding any other provision of the Plan to the contrary, no Holder who is a Director or an “executive officer” of the Company within the
meaning of Section 13(k) of the Exchange Act shall be permitted to make payment with respect to any Awards granted under the Plan, or continue any
extension of credit with respect to such payment, with a loan from the Company or a loan arranged by the Company in violation of Section 13(k) of the
Exchange Act.

11.2 Tax Withholding. The Company or any Affiliate shall have the authority and the right to deduct or withhold, or require a Holder to remit to the
Company, an amount sufficient to satisfy federal, state, local and foreign taxes (including the Holder’s FICA or employment tax obligation) required by law
to be withheld with respect to any taxable event concerning a Holder arising as a result of the Plan. The Administrator may in its sole discretion and in
satisfaction of the foregoing requirement allow a Holder to satisfy such obligations by any payment means described in Section 11.1 hereof, including
without limitation, by allowing such Holder to elect to have the Company withhold Shares otherwise issuable under an Award (or allow the surrender of
Shares). The number of Shares which may be so withheld or surrendered shall be limited to the number of Shares which have a Fair Market Value on the
date of withholding or repurchase equal to the aggregate amount of such liabilities based on the minimum statutory withholding rates for federal, state,
local and foreign income tax and payroll tax purposes that are applicable to such

supplemental taxable income. The Administrator shall determine the fair market value of the Shares, consistent with applicable provisions of the Code, for
tax withholding obligations due in connection with a broker-assisted cashless Option or Stock Appreciation Right exercise involving the sale of Shares to
pay the Option or Stock Appreciation Right exercise price or any tax withholding obligation.

11.3 Transferability of Awards.

(a) Except as otherwise provided in Sections 11.3(b) and 11.3(c) hereof:

(i) No Award under the Plan may be sold, pledged, assigned or transferred in any manner other than by will or the laws of descent and distribution or,
subject to the consent of the Administrator, pursuant to a DRO, unless and until such Award has been exercised, or the Shares underlying such Award have
been issued, and all restrictions applicable to such Shares have lapsed;

(ii) No Award or interest or right therein shall be liable for the debts, contracts or engagements of the Holder or the Holder’s successors in interest or shall
be subject to disposition by transfer, alienation, anticipation, pledge, hypothecation, encumbrance, assignment or any other means whether such disposition
be voluntary or involuntary or by operation of law by judgment, levy, attachment, garnishment or any other legal or equitable proceedings (including
bankruptcy) unless and until such Award has been exercised, or the Shares underlying such Award have been issued, and all restrictions applicable to such
Shares have lapsed, and any attempted disposition of an Award prior to the satisfaction of these conditions shall be null and void and of no effect, except to
the extent that such disposition is permitted by clause (i) of this provision; and

(iii) During the lifetime of the Holder, only the Holder may exercise an Award (or any portion thereof) granted to such Holder under the Plan, unless it has
been disposed of pursuant to a DRO; after the death of the Holder, any exercisable portion of an Award may, prior to the time when such portion becomes
unexercisable under the Plan or the applicable Program or Award Agreement, be exercised by the Holder’s personal representative or by any person
empowered to do so under the deceased Holder’s will or under the then applicable laws of descent and distribution.

(b) Notwithstanding Section 11.3(a) hereof, the Administrator, in its sole discretion, may determine to permit a Holder or a Permitted Transferee of such
Holder to transfer an Award to any one or more Permitted Transferees, subject to the following terms and conditions: (i) an Award transferred to a
Permitted Transferee shall not be assignable or transferable by the Permitted Transferee (other than to another Permitted Transferee of the applicable
Holder) other than by will or the laws of descent and distribution; (ii) an Award transferred to a Permitted Transferee shall continue to be subject to all the
terms and conditions of the Award as applicable to the original Holder (other than the ability to further transfer the Award); and (iii) the Holder (or
transferring Permitted Transferee) and the Permitted Transferee shall execute any and all documents requested by the Administrator, including, without
limitation documents to (A) confirm the status of the transferee as a Permitted Transferee, (B) satisfy any requirements for an exemption for the transfer
under applicable federal, state and foreign securities laws and (C) evidence the transfer.

(c) Notwithstanding Section 11.3(a) hereof, a Holder may, in the manner determined by the Administrator, designate a beneficiary to exercise the rights of
the Holder and to receive any distribution with respect to any Award upon the Holder’s death. A beneficiary, legal guardian, legal representative, or other
person claiming any rights pursuant to the Plan is subject to all terms and conditions of the Plan and any Program or Award Agreement applicable to the
Holder, except to the extent the Plan, the Program and the Award Agreement otherwise provide, and to any additional restrictions deemed necessary or
appropriate by the Administrator. If the Holder is married or a domestic partner in a domestic partnership qualified under Applicable Law and resides in a
community property state, a designation of a person other than the Holder’s spouse or domestic partner, as applicable, as his or her beneficiary with respect
to more than fifty percent (50%) of the Holder’s interest in the Award shall not be effective without the prior written or electronic consent of the Holder’s
spouse or domestic partner, as applicable. If no beneficiary has been designated or survives the Holder, payment shall be made to the person entitled thereto
pursuant to the Holder’s will or the laws of descent and distribution. Subject to the foregoing, a beneficiary designation may be changed or revoked by a
Holder at any time; provided that the change or revocation is filed with the Administrator prior to the Holder’s death.

11.4 Conditions to Issuance of Shares.

(a) Notwithstanding anything herein to the contrary, the Company shall not be required to issue or deliver any certificates or make any book entries
evidencing Shares pursuant to the exercise of any Award, unless and until the Board or the Committee has determined, with advice of counsel, that the
issuance of such shares is in compliance with all Applicable Law, and the Shares are covered by an effective registration statement or applicable exemption
from registration. In addition to the terms and conditions provided herein, the Board or the Committee may require

that a Holder make such reasonable covenants, agreements, and representations as the Board or the Committee, in its discretion, deems advisable in order
to comply with Applicable Law.

(b) All Share certificates delivered pursuant to the Plan and all Shares issued pursuant to book entry procedures are subject to any stop-transfer orders and
other restrictions as the Administrator deems necessary or advisable to comply with Applicable Law. The Administrator may place legends on any Share
certificate or book entry to reference restrictions applicable to the Shares.

(c) The Administrator shall have the right to require any Holder to comply with any timing or other restrictions with respect to the settlement, distribution
or exercise of any Award, including a window-period limitation, as may be imposed in the sole discretion of the Administrator.

(d) No fractional Shares shall be issued and the Administrator shall determine, in its sole discretion, whether cash shall be given in lieu of fractional Shares
or whether such fractional Shares shall be eliminated by rounding down.

(e) Notwithstanding any other provision of the Plan, unless otherwise determined by the Administrator or required by any Applicable Law, the Company
shall not deliver to any Holder certificates evidencing Shares issued in connection with any Award and instead such Shares shall be recorded in the books
of the Company (or, as applicable, its transfer agent or stock plan administrator).

11.5 Forfeiture and Claw-Back Provisions. Pursuant to its general authority to determine the terms and conditions applicable to Awards under the Plan, the
Administrator shall have the right to provide, in an Award Agreement or otherwise, or to require a Holder to agree by separate written or electronic
instrument, that:

(a) (i) Any proceeds, gains or other economic benefit actually or constructively received by the Holder upon any receipt or exercise of the Award, or upon
the receipt or resale of any Shares underlying the Award, must be paid to the Company, and (ii) the Award shall terminate and any unexercised portion of
the Award (whether or not vested) shall be forfeited, if (x) a Termination of Service occurs prior to a specified date, or within a specified time period
following receipt or exercise of the Award, or (y) the Holder at any time, or during a specified time period, engages in any activity in competition with the
Company, or which is inimical, contrary or harmful to the interests of the Company, as further defined by the Administrator or (z) the Holder incurs a
Termination of Service for “cause” (as such term is defined in the sole discretion of the Administrator, or as set forth in a written agreement relating to such
Award between the Company and the Holder); and

(b) All Awards (including any proceeds, gains or other economic benefit actually or constructively received by the Holder upon any receipt or exercise of
any Award or upon the receipt or resale of any Shares underlying the Award) shall be subject to the provisions of any claw-back policy implemented by the
Company, including, without limitation, any claw-back policy adopted to comply with the requirements of Applicable Law, including, without limitation,
the Dodd-Frank Wall Street Reform and Consumer Protection Act and any rules or regulations promulgated thereunder, to the extent set forth in such claw-
back policy and/or in the applicable Award Agreement.

11.6 Prohibition on Repricing. Subject to Section 13.2 hereof, the Administrator shall not, without the approval of the stockholders of the Company, (i)
authorize the amendment of any outstanding Option or Stock Appreciation Right to reduce its price per Share, or (ii) cancel any Option or Stock
Appreciation Right in exchange for cash or another Award when the Option or Stock Appreciation Right price per Share exceeds the Fair Market Value of
the underlying Shares.

11.7 Leave of Absence. Unless the Administrator provides otherwise, vesting of Awards granted hereunder shall be suspended during any unpaid leave of
absence. A Holder shall not cease to be considered an Employee in the case of any (a) leave of absence approved by the Company or (b) transfer between
locations of the Company or between the Company and any of its Affiliates or any successor thereof.

ARTICLE 12.

ADMINISTRATION

12.1 Administrator. The Committee and the Board shall administer the Plan (except as otherwise permitted herein). Any action taken by the Board in
connection with the administration of the Plan shall not be deemed approved by the Board unless such actions are approved by a majority of the Non-
Employee Directors. Except as may otherwise be provided in any charter of the Committee or the Board, appointment of Committee and Board members
shall be effective upon acceptance of appointment. Committee and Board members may resign at any time by delivering

written or electronic notice to the Board. Vacancies in the Committee and the Board may only be filled by the Board.

12.2 Duties and Powers of Administrator. It shall be the duty of the Administrator to conduct the general administration of the Plan in accordance with its
provisions. The Administrator shall have the power to interpret the Plan, the Program and the Award Agreement, and to adopt such rules for the
administration, interpretation and application of the Plan as are not inconsistent therewith, to interpret, amend or revoke any such rules and to amend any
Program or Award Agreement; provided that the rights or obligations of the Holder of the Award that is the subject of any such Program or Award
Agreement are not affected materially and adversely by such amendment, unless the consent of the Holder is obtained or such amendment is otherwise
permitted under Section 13.10 hereof. Any such grant or award under the Plan need not be the same with respect to each Holder. In its sole discretion, the
Board may at any time and from time to time exercise any and all rights and duties of the Committee under the Plan except as described in Section 12.1
above and with respect to matters which under Rule 16b-3 under the Exchange Act or any successor rule, or the rules of any securities exchange or
automated quotation system on which the Shares are listed, quoted or traded are required to be determined in the sole discretion of the Committee.

12.3 Action by the Committee. Unless otherwise established by the Board or in any charter of the Committee, a majority of the Committee shall constitute
a quorum and the acts of a majority of the members present at any meeting at which a quorum is present, and acts approved in writing by all members of
the Committee in lieu of a meeting, shall be deemed the acts of the Committee. Each member of the Committee is entitled to, in good faith, rely or act upon
any report or other information furnished to that member by any officer or other employee of the Company or any Affiliate, the Company’s independent
certified public accountants, or any executive compensation consultant or other professional retained by the Company to assist in the administration of the
Plan.

12.4 Authority of Administrator. Subject to the Company’s Bylaws, the Committee’s Charter and any specific designation in the Plan, the Administrator
has the exclusive power, authority and sole discretion to:

(a) Adopt procedures from time to time in the Administrator’s discretion to ensure that an Employee is eligible to participate in the Plan prior to the
granting of any Awards to such Employee under the Plan (including, without limitation, a requirement, if any, that each such Employee certify to the
Company prior to the receipt of an Award under the Plan that he or she has not been previously employed by the Company or a Subsidiary, or if previously
employed, has had a bona fide period of non-employment, and that the grant of Awards under the Plan is an inducement material to his or her agreement to
enter into employment with the Company or a Subsidiary);

(b) Designate Eligible Individuals to receive Awards;

(c) Determine the type or types of Awards to be granted to each Eligible Individual;

(d) Determine the number of Awards to be granted and the number of Shares to which an Award will relate;

(e) Determine the terms and conditions of any Award granted pursuant to the Plan, including, but not limited to, the exercise price, grant price, or purchase
price, any performance criteria, any restrictions or limitations on the Award, any schedule for vesting, lapse of forfeiture restrictions or restrictions on the
exercisability of an Award, and accelerations or waivers thereof, and any provisions related to non-competition and recapture of gain on an Award, based in
each case on such considerations as the Administrator in its sole discretion determines;

(f) Determine whether, to what extent, and pursuant to what circumstances an Award may be settled in, or the exercise price of an Award may be paid in
cash, Shares, other Awards, or other property, or an Award may be canceled, forfeited, or surrendered;

(g) Prescribe the form of each Award Agreement, which need not be identical for each Holder;

(h) Decide all other matters that must be determined in connection with an Award;

(i) Establish, adopt, or revise any rules and regulations as it may deem necessary or advisable to administer the Plan;

(j) Interpret the terms of, and any matter arising pursuant to, the Plan, any Program or any Award Agreement;

(k) Make all other decisions and determinations that may be required pursuant to the Plan or as the Administrator deems necessary or advisable to
administer the Plan; and

(l) Accelerate wholly or partially the vesting or lapse of restrictions of any Award or portion thereof at any time after the grant of an Award, subject to
whatever terms and conditions it selects and Sections 3.4 and 13.2(d) hereof.

12.5 Decisions Binding. The Administrator’s interpretation of the Plan, any Awards granted pursuant to the Plan, any Program, any Award Agreement and
all decisions and determinations by the Administrator with respect to the Plan are final, binding, and conclusive on all parties.

12.6 Delegation of Authority. To the extent permitted by Applicable Law, the Board or Committee may from time to time delegate to a committee of one or
more Non-Employee Directors or officers of the Company the authority to amend Awards or to take other administrative actions pursuant to Article 12.
Notwithstanding the foregoing, only the Committee and the Board, acting in accordance with this Article 12, may grant Awards hereunder. Any delegation
hereunder shall be subject to the restrictions and limits that the Board or Committee specifies at the time of such delegation, and the Board may at any time
rescind the authority so delegated or appoint a new delegatee. At all times, the delegatee appointed under this Section 12.6 shall serve in such capacity at
the pleasure of the Board and the Committee.

ARTICLE 13.

MISCELLANEOUS PROVISIONS

13.1 Amendment, Suspension or Termination of the Plan. Except as otherwise provided in this Section 13.1, the Plan may be wholly or partially amended
or otherwise modified, suspended or terminated at any time or from time to time by the Board or the Committee. However, without approval of the
Company’s stockholders given within twelve (12) months before or after the action by the Administrator, no action of the Administrator may, except as
provided in Section 13.2 hereof (a) reduce the price per share of any outstanding Option or Stock Appreciation Right granted under the Plan, or (b) cancel
any Option or Stock Appreciation Right in exchange for cash or another Award when the Option or Stock Appreciation Right price per share exceeds the
Fair Market Value of the underlying Shares. Except as provided in Section 13.10 hereof, no amendment, suspension or termination of the Plan shall,
without the consent of the Holder, materially and adversely affect any rights or obligations under any Award theretofore granted or awarded, unless the
Award itself otherwise expressly so provides.

13.2 Changes in Common Stock or Assets of the Company, Acquisition or Liquidation of the Company and Other Corporate Events.

(a) In the event of any stock dividend, stock split, combination or exchange of shares, merger, consolidation or other distribution (other than normal cash
dividends) of Company assets to stockholders, or any other change affecting the shares of the Company’s stock or the share price of the Company’s stock
other than an Equity Restructuring, the Administrator may make equitable adjustments, if any, to reflect such change with respect to (i) the aggregate
number and kind of shares that may be issued under the Plan (including, but not limited to, adjustments of the limitations in Section 3.1 hereof on the
maximum number and kind of shares which may be issued under the Plan); (ii) the number and kind of shares of Common Stock (or other securities or
property) subject to outstanding Awards; (iii) the terms and conditions of any outstanding Awards (including, without limitation, any applicable
performance targets or criteria with respect thereto); and (iv) the grant or exercise price per share for any outstanding Awards under the Plan.

(b) In the event of any transaction or event described in Section 13.2(a) hereof or any unusual or nonrecurring transactions or events affecting the
Company, any Affiliate of the Company, or the financial statements of the Company or any Affiliate, or of changes in Applicable Law, the Administrator,
in its sole discretion, and on such terms and conditions as it deems appropriate, either by the terms of the Award or by action taken prior to the occurrence
of such transaction or event and either automatically or upon the Holder’s request, is hereby authorized to take any one or more of the following actions
whenever the Administrator determines that such action is appropriate in order to prevent dilution or enlargement of the benefits or potential benefits
intended to be made available under the Plan or with respect to any Award under the Plan, to facilitate such transactions or events or to give effect to such
changes in laws, regulations or principles:

(i) To provide for either (A) termination of any such Award in exchange for an amount of cash and/or other property, if any, equal to the amount that would
have been attained upon the exercise of such Award or realization of the Holder’s rights (and, for the avoidance of doubt, if as of the date of the occurrence
of the transaction or event described in this Section 13.2 the Administrator determines in good faith that no amount would have been attained upon the
exercise of such Award or realization of the Holder’s rights, then such Award may be terminated by the Company without payment) or (B) the replacement
of such Award with other rights or property selected by the Administrator in its sole discretion having an aggregate value not exceeding the amount that
could have been

attained upon the exercise of such Award or realization of the Holder’s rights had such Award been currently exercisable or payable or fully vested;

(ii) To provide that such Award be assumed by the successor or survivor corporation, or a parent or subsidiary thereof, or shall be substituted for by similar
options, rights or awards covering the stock of the successor or survivor corporation, or a parent or subsidiary thereof, with appropriate adjustments as to
the number and kind of shares and prices;

(iii) To make adjustments in the number and type of shares of the Company’s stock (or other securities or property) subject to outstanding Awards, and in
the number and kind of outstanding Restricted Stock or Deferred Stock and/or in the terms and conditions of (including the grant or exercise price), and the
criteria included in, outstanding Awards and Awards which may be granted in the future;

(iv) To provide that such Award shall be exercisable or payable or fully vested with respect to all shares covered thereby, notwithstanding anything to the
contrary in the Plan or the applicable Program or Award Agreement; and

(v) To provide that the Award cannot vest, be exercised or become payable after such event.

(c) In connection with the occurrence of any Equity Restructuring, and notwithstanding anything to the contrary in Sections 13.2(a) and 13.2(b) hereof:

(i) The number and type of securities subject to each outstanding Award and the exercise price or grant price thereof, if applicable, shall be equitably
adjusted; and/or

(ii) The Administrator shall make such equitable adjustments, if any, as the Administrator in its discretion may deem appropriate to reflect such Equity
Restructuring with respect to the aggregate number and kind of shares that may be issued under the Plan (including, but not limited to, adjustments of the
limitations in Section 3.1 hereof on the maximum number and kind of shares which may be issued under the Plan).

The adjustments provided under this Section 13.2(c) shall be nondiscretionary and shall be final and binding on the affected Holder and the Company.

(d) Change in Control.

(i) Notwithstanding any other provision of the Plan, in the event of a Change in Control, each outstanding Award shall be assumed or an equivalent Award
substituted by the successor corporation or a parent or subsidiary of the successor corporation, in each case, as determined by the Administrator.

(ii) In the event that the successor corporation in a Change in Control and its parents and subsidiaries refuse to assume or substitute for any Award in
accordance with Section 13.2(d)(i) hereof, each such non-assumed/substituted Award, except for any Performance Awards, shall become fully vested and,
as applicable, exercisable and shall be deemed exercised, immediately prior to the consummation of such transaction, and all forfeiture restrictions on any
or all such Awards shall lapse at such time. For the avoidance of doubt, the vesting of any Performance Awards not assumed in a Change in Control will not
be automatically accelerated pursuant to this Section 13.2(d)(ii) and will instead vest pursuant to the terms and conditions of the applicable Award
Agreement upon a Change in Control where the successor corporation and its parents and subsidiaries refuse to assume or substitute for any Award in
accordance with Section 13.2(d)(i) hereof. If an Award vests and, as applicable, is exercised in lieu of assumption or substitution in connection with a
Change in Control, the Administrator shall notify the Holder of such vesting and any applicable exercise period, and the Award shall terminate upon the
Change in Control. For the avoidance of doubt, if the value of an Award that is terminated in connection with this Section 13.2(d)(ii) is zero or negative at
the time of such Change in Control, such Award shall be terminated upon the Change in Control without payment of consideration therefor.

(e) The Administrator may, in its sole discretion, include such further provisions and limitations in any Award, agreement or certificate, as it may deem
equitable and in the best interests of the Company that are not inconsistent with the provisions of the Plan.

(f) The existence of the Plan, the Program, the Award Agreement and the Awards granted hereunder shall not affect or restrict in any way the right or power
of the Company or the stockholders of the Company to make or authorize any adjustment, recapitalization, reorganization or other change in the
Company’s capital structure or its business, any merger or consolidation of the Company, any issue of stock or of options, warrants or rights to purchase
stock or of bonds, debentures, preferred or prior preference stocks whose rights are superior to or affect the Common Stock

or the rights thereof or which are convertible into or exchangeable for Common Stock, or the dissolution or liquidation of the Company, or any sale or
transfer of all or any part of its assets or business, or any other corporate act or proceeding, whether of a similar character or otherwise.

(g) In the event of any pending stock dividend, stock split, combination or exchange of shares, merger, consolidation or other distribution (other than
normal cash dividends) of Company assets to stockholders, or any other change affecting the Shares or the share price of the Common Stock including any
Equity Restructuring, for reasons of administrative convenience, the Company in its sole discretion may refuse to permit the exercise of any Award during
a period of thirty (30) days prior to the consummation of any such transaction.

13.3 Stockholder Approval of the Plan not Required. It is expressly intended that approval of the Company’s stockholders not be required as a condition of
the effectiveness of the Plan, and the Plan’s provisions shall be interpreted in a manner consistent with such intent for all purposes. Specifically, Nasdaq
Stock Market Rule 5635(c) generally requires stockholder approval for stock option plans or other equity compensation arrangements adopted by
companies whose securities are listed on the Nasdaq Stock Market pursuant to which stock awards or stock may be acquired by officers, directors,
employees, or consultants of such companies. Nasdaq Stock Market Rule 5635(c)(4) provides an exception to this requirement for issuances of securities to
a person not previously an employee or director of the issuer, or following a bona fide period of non-employment, as an inducement material to the
individual’s entering into employment with the issuer; provided, such issuances are approved by either the issuer’s compensation committee comprised of a
majority of independent directors or a majority of the issuer’s independent directors. Notwithstanding anything to the contrary herein, Awards under the
Plan may only be made to Employees who have not previously been an Employee or Director of the Company or a Subsidiary, or following a bona fide
period of non-employment by the Company or a Subsidiary, as an inducement material to the Employee’s entering into employment with the Company or a
Subsidiary. Awards under the Plan will be approved by (i) the Company’s Compensation Committee comprised of a majority of the Company’s Non-
Employee Directors or (ii) a majority of the Company’s Non-Employee Directors. Accordingly, pursuant to Nasdaq Stock Market Rule 5635(c)(4), the
issuance of Awards and the Shares issuable upon exercise or vesting of such Awards pursuant to the Plan are not subject to the approval of the Company’s
stockholders.

13.4 No Stockholders Rights. Except as otherwise provided herein, a Holder shall have none of the rights of a stockholder with respect to Shares covered
by any Award until the Holder becomes the record owner of such Shares.

13.5 Paperless Administration. In the event that the Company establishes, for itself or using the services of a third party, an automated system for the
documentation, granting or exercise of Awards, such as a system using an internet website or interactive voice response, then the paperless documentation,
granting or exercise of Awards by a Holder may be permitted through the use of such an automated system.

13.6 Effect of Plan upon Other Compensation Plans. The adoption of the Plan shall not affect any other compensation or incentive plans in effect for the
Company or any Affiliate. Nothing in the Plan shall be construed to limit the right of the Company or any Affiliate: (a) to establish any other forms of
incentives or compensation for Employees or other service providers of the Company or any Affiliate, or (b) to grant or assume options or other rights or
awards otherwise than under the Plan in connection with any proper corporate purpose including without limitation, the grant or assumption of options in
connection with the acquisition by purchase, lease, merger, consolidation or otherwise, of the business, stock or assets of any corporation, partnership,
limited liability company, firm or association.

13.7 Compliance with Laws. The Plan, the granting and vesting of Awards under the Plan and the issuance and delivery of Shares and the payment of
money under the Plan or under Awards granted or awarded hereunder are subject to compliance with all Applicable Law, and to such approvals by any
listing, regulatory or governmental authority as may, in the opinion of counsel for the Company, be necessary or advisable in connection therewith. Any
securities delivered under the Plan shall be subject to such restrictions, and the person acquiring such securities shall, if requested by the Company, provide
such assurances and representations to the Company as the Company may deem necessary or desirable to assure compliance with all Applicable Law. To
the extent permitted by Applicable Law, the Plan and Awards granted or awarded hereunder shall be deemed amended to the extent necessary to conform to
such Applicable Law.

13.8 Titles and Headings, References to Sections of the Code or Exchange Act. The titles and headings of the Sections in the Plan are for convenience of
reference only and, in the event of any conflict, the text of the Plan, rather than such titles or headings, shall control. References to sections of the Code or
the Exchange Act shall include any amendment or successor thereto.

13.9 Governing Law. The Plan and any agreements hereunder shall be administered, interpreted and enforced under the internal laws of the State of
Delaware without regard to conflicts of laws thereof or of any other jurisdiction.

13.10 Section 409A. To the extent that the Administrator determines that any Award granted under the Plan is subject to Section 409A of the Code, the
Program pursuant to which such Award is granted and the Award Agreement evidencing such Award shall incorporate the terms and conditions required by
Section 409A of the Code. To the extent applicable, the Plan, the Program and any Award Agreements shall be interpreted in accordance with Section 409A
of the Code and Department of Treasury regulations and other interpretive guidance issued thereunder, including without limitation any such regulations or
other guidance that may be issued after the Effective Date. Notwithstanding any provision of the Plan to the contrary, in the event that following the
Effective Date the Administrator determines that any Award may be subject to Section 409A of the Code and related Department of Treasury guidance
(including such Department of Treasury guidance as may be issued after the Effective Date), the Administrator may adopt such amendments to the Plan
and the applicable Program and Award Agreement or adopt other policies and procedures (including amendments, policies and procedures with retroactive
effect), or take any other actions, that the Administrator determines are necessary or appropriate to (a) exempt the Award from Section 409A of the Code
and/or preserve the intended tax treatment of the benefits provided with respect to the Award, or (b) comply with the requirements of Section 409A of the
Code and related Department of Treasury guidance and thereby avoid the application of any penalty taxes under such Section.

13.11 No Rights to Awards. No Eligible Individual or other person shall have any claim to be granted any Award pursuant to the Plan, and neither the
Company nor the Administrator is obligated to treat Eligible Individuals, Holders or any other persons uniformly.

13.12 Unfunded Status of Awards. The Plan is intended to be an “unfunded” plan for incentive compensation. With respect to any payments not yet made
to a Holder pursuant to an Award, nothing contained in the Plan or any Program or Award Agreement shall give the Holder any rights that are greater than
those of a general creditor of the Company or any Affiliate.

13.13 Indemnification. To the extent allowable pursuant to Applicable Law, each member of the Committee or of the Board and any officer or other
employee to whom authority to administer any component of the Plan is delegated shall be indemnified and held harmless by the Company from any loss,
cost, liability, or expense that may be imposed upon or reasonably incurred by such member in connection with or resulting from any claim, action, suit, or
proceeding to which he or she may be a party or in which he or she may be involved by reason of any action or failure to act pursuant to the Plan and
against and from any and all amounts paid by him or her in satisfaction of judgment in such action, suit, or proceeding against him or her; provided he or
she gives the Company an opportunity, at its own expense, to handle and defend the same before he or she undertakes to handle and defend it on his or her
own behalf. The foregoing right of indemnification shall not be exclusive of any other rights of indemnification to which such persons may be entitled
pursuant to the Company’s Certificate of Incorporation or Bylaws, as a matter of law, or otherwise, or any power that the Company may have to indemnify
them or hold them harmless.

13.14 Relationship to other Benefits. No payment pursuant to the Plan shall be taken into account in determining any benefits under any pension,
retirement, savings, profit sharing, group insurance, welfare or other benefit plan of the Company or any Affiliate except to the extent otherwise expressly
provided in writing in such other plan or an agreement thereunder.

13.15 Expenses. The expenses of administering the Plan shall be borne by the Company and its Affiliates.

Exhibit 10.20(b)

ARDELYX, INC.
THIRD AMENDED AND RESTATED
NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM

Non-employee members of the board of directors (the “Board”) of Ardelyx, Inc. (the “Company”) shall be eligible to receive cash
and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”), which was adopted pursuant
to the Board’s resolutions on May 23, 2014, and amended pursuant to the Board’s resolutions on March 3, 2017, March 14, 2019, March 11,
2021,  June  15,  2022,  and  December  5,  2023.  The  cash  and  equity  compensation  described  in  this  Program  shall  be  paid  or  be  made,  as
applicable, automatically and without further action of the Board, to each member of the Board who is not an employee of the Company or
any  parent  or  subsidiary  of  the  Company  (each,  a  “Non-Employee  Director”)  who  may  be  eligible  to  receive  such  cash  or  equity
compensation,  unless  such  Non-Employee  Director  declines  the  receipt  of  such  cash  or  equity  compensation  by  written  notice  to  the
Company. This Program shall remain in effect until it is revised or rescinded by further action of the Board. This Program may be amended,
modified or terminated by the Board at any time in its sole discretion. The terms and conditions of this Program shall supersede any prior
cash and/or equity compensation arrangements for service as a member of the Board between the Company and any of its Non-Employee
Directors.  This  Program  shall  become  effective  on  the  date  of  the  closing  of  the  initial  public  offering  of  Company  common  stock  (the
“Effective Date”).

1.    Cash Compensation.

the Board.

(a)    Annual Retainers. Each Non-Employee Director shall be eligible to receive an annual retainer of $50,000 for service on

(b)    Additional Annual Retainers. In addition, a Non-Employee Director shall receive the following annual retainers:

annual retainer of $35,000 for such service.

(i)    Chairman of the Board. A Non-Employee Director serving as Chairman of the Board shall receive an additional

(ii)    Audit Committee. A Non-Employee Director serving as Chairperson of the Audit Committee shall receive an
additional annual retainer of $20,000 for such service. A Non-Employee Director serving as a member of the Audit Committee (other than
the Chairperson) shall receive an additional annual retainer of $10,000 for such service.

(iii)    Compensation Committee. A Non-Employee Director serving as Chairperson of the Compensation Committee
shall receive an additional annual retainer of $15,000 for such service. A Non-Employee Director serving as a member of the Compensation
Committee (other than the Chairperson) shall receive an additional annual retainer of $7,500 for such service.

(vi)     Nominating and Corporate Governance Committee. A Non-Employee Director serving as Chairperson of the
Nominating and Corporate Governance Committee shall receive an additional annual retainer of $10,000 for such service. A Non-Employee
Director  serving  as  a  member  of  the  Nominating  and  Corporate  Governance  Committee  (other  than  the  Chairperson)  shall  receive  an
additional annual retainer of $5,000 for such service.

        (c)    Payment of Retainers. The annual retainers described in Sections 1(a) and 1(b) (the “Annual Retainers”) shall be paid by the
Company in a single cash lump sum immediately following the Effective Date and on the date of each annual meeting of the Company’s
stockholders after the Effective Date. In  the  event  a  Non-Employee  Director  is  initially  elected  or  appointed  to  the  Board  or  a  committee
thereunder  on  a  date  other  than  the  date  of  an  annual  meeting  of  the  Company’s  stockholders,  the  Annual  Retainers  paid  to  such  Non-
Employee Director shall be paid on the date of election or appointment, prorated to reflect the number of months (rounded up to the next
whole month) remaining until the next annual meeting of the Company’s stockholders.

                (d)          Election  to  Receive  Stock  in  Lieu  of  Cash.  After  the  first  payment  of  Annual  Retainers  following  the  Effective  Date,  Non-
Employee Directors shall have the ability to elect to receive the Annual Retainers in an award of stock in lieu of cash pursuant to an election
form provided by the Company for such purpose. Non-Employee Directors must complete and deliver the election form to the Company no
later  than  15  days  prior  to  the  next  annual  meeting  of  the  Company’s  stockholders.  In  the  event  that  a  Non-Employee  Director  makes  an
election to receive the Annual Retainers in an award of stock in lieu of cash, on the annual meeting of the Company’s stockholders, he or she
will automatically be granted that number of shares of fully vested Company common stock calculated by dividing the aggregate amount of
the Annual Retainers by the Fair Market Value (as defined in the Equity Plan (as defined below)) of a share of Company common stock on
the date of grant, rounded down to the nearest whole share. The stock awards shall be granted under and shall be subject to the terms and
provisions of the Company’s 2014 Equity Incentive Award Plan or any other applicable Company equity incentive plan then-maintained by
the Company (the “Equity Plan”). In the event of any inconsistency between the Equity Plan and this Program, the terms of this Program
shall control.

2.        Equity  Compensation.  Non-Employee  Directors  shall  be  granted  the  equity  awards  described  below.  The  awards  described
below shall be granted under and shall be subject to the terms and provisions of the Equity Plan and shall be granted subject to the execution
and delivery of award agreements, including attached exhibits, in substantially the forms previously approved by the Board. All applicable
terms of the Equity Plan apply to this Program as if fully set forth herein, and all grants of stock options hereby are subject in all respects to
the terms of the Equity Plan. In the event of any inconsistency between the Equity Plan and this Program, the terms of this Program shall
control.

    (a)    Initial Awards. Each Non-Employee Director who is initially elected or appointed to the Board after the Effective Date shall
be eligible to receive, on the date of such initial election or appointment, an option to purchase shares of the Company’s common stock
with a grant date fair value of $300,000, but with a maximum number of shares of 200,000 shares of the Company’s common stock.
The awards described in this Section 2(a) shall be referred to as “Initial Awards.” No Non-Employee Director shall be granted more than one
Initial Award.

    (b)    Subsequent Awards. A Non-Employee Director who (i) has been serving on the Board for at least six months as of the date of
any  annual  meeting  of  the  Company’s  stockholders  after  the  Effective  Date  and  (ii)  will  continue  to  serve  as  a  Non-Employee  Director
immediately following such meeting, shall be automatically granted, on the date of such annual meeting, an option to purchase shares of the
Company’s common stock with a grant date fair value of $200,000, but with a maximum number of shares of 100,000 shares of
the Company’s common stock. The awards described in this Section 2(b) shall be referred to as “Subsequent Awards.” For the avoidance of
doubt, a Non-Employee Director elected for the first time to the Board at an annual meeting of the Company’s stockholders shall only receive
an Initial Award in connection with such election, and shall not receive any Subsequent Award on the date of such meeting as well.

(c)        Termination  of  Service  of  Employee  Directors. Members  of  the  Board  who  are  employees  of  the  Company  or  any
parent  or  subsidiary  of  the  Company  who  subsequently  terminate  their  service  with  the  Company  and  any  parent  or  subsidiary  of  the
Company and remain on the Board will not receive an Initial Award pursuant to Section 2(a) above, but to the extent that they are otherwise
eligible,  will  be  eligible  to  receive,  after  termination  from  service  with  the  Company  and  any  parent  or  subsidiary  of  the  Company,
Subsequent Awards as described in Section 2(b) above.

(d)    Terms of Awards Granted to Non-Employee Directors

        (i)     Purchase Price. The per share exercise price of each option granted to a Non-Employee Director shall equal the Fair

Market Value (as defined in the Equity Plan) of a share of common stock on the date the option is granted.

        (ii)    Vesting. Each Initial Award shall vest and become exercisable with respect to 1/36th of the shares subject to the Initial
Award on each monthly anniversary of the date of grant, subject to the Non-Employee Director continuing in service on the Board through
each such vesting

2

        
date. Each Subsequent Award shall vest and become exercisable with respect to 1/12th of the shares subject to the Subsequent Award on each
monthly anniversary of the date of grant, which vesting will accelerate in full immediately prior to the next annual meeting of the Company’s
stockholders after the date of grant to the extent unvested as of such date, subject to the Non-Employee Director continuing in service on the
Board through each such vesting date. Unless as otherwise specified herein, no portion of an Initial Award or Subsequent Award which is
unvested or unexercisable at the time of a Non-Employee Director’s termination of service on the Board shall become vested and exercisable
thereafter.  All  of  a  Non-Employee  Director’s  Initial  Awards  and  Subsequent  Awards,  and  any  other  stock  options  or  other  equity-based
awards outstanding and held by the Non-Employee Director, shall vest in full immediately prior to the occurrence of a Change in Control (as
defined in the Equity Plan), to the extent outstanding at such time.

the option is granted.

(iii)    Term. The term of each stock option granted to a Non-Employee Director shall be ten (10) years from the date

3.        Reimbursements. The  Company  shall  reimburse  each  Non-Employee  Director  for  all  reasonable,  documented,  out-of-pocket
travel  and  other  business  expenses  incurred  by  such  Non-Employee  Director  in  the  performance  of  his  or  her  duties  to  the  Company  in
accordance with the Company’s applicable expense reimbursement policies and procedures as in effect from time to time.

* * * * *

3

Exhibit 23.1

We consent to the incorporation by reference in the following Registration Statements:

Consent of Independent Registered Public Accounting Firm

1. Registration Statement on Form S-8 (No. 333-197408) pertaining to the 2008 Stock Incentive Plan, as amended, the 2014 Equity Incentive Award

Plan and the 2014 Employee Stock Purchase Plan of Ardelyx, Inc.,

2. Registration Statements on Form S-8 (Nos. 333-202663 and 333-230156) pertaining to the 2014 Equity Incentive Award Plan and the 2014

Employee Stock Purchase Plan of Ardelyx, Inc.,

3. Registration Statements on Form S-3 (Nos. 333-205630, 333-213085, 333-239764 and 333-269297) of Ardelyx, Inc.,

4. Registration Statements on Form S-8 (Nos. 333-210079, 333-216154, 333-223694 and 333-237057) pertaining to the 2014 Equity Incentive

Award Plan of Ardelyx, Inc.,

5. Registration Statement on Form S-8 (No. 333-214538) pertaining to the 2016 Employment Commencement Incentive Plan of Ardelyx, Inc.,

6. Registration Statement on Form S-8 (Nos. 333-254187 and 333-270314) pertaining to the 2014 Equity Incentive Award Plan, the 2014 Employee

Stock Purchase Plan and the 2016 Employment Commencement Incentive Plan of Ardelyx, Inc., and

7. Registration Statement on Form S-8 (333-263145) pertaining to the 2014 Equity Incentive Award Plan and the 2016 Employment Commencement

Incentive Plan of Ardelyx, Inc.;

of our reports dated February 22, 2024, with respect to the financial statements of Ardelyx, Inc. and the effectiveness of internal control over financial
reporting of Ardelyx, Inc. included in this Annual Report (Form 10-K) of Ardelyx, Inc. for the year ended December 31, 2023.

/s/ Ernst & Young LLP
Boston, Massachusetts

February 22, 2024

CERTIFICATION

Exhibit 31.1

I, Michael Raab, certify that:

1.

I have reviewed this Annual Report on Form 10-K of Ardelyx, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in

Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

(a)

(b)

(c)

(d)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent
fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to
materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)

(b)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are
reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal
control over financial reporting.

Date: February 22, 2024

By:

/s/ Michael Raab

Michael Raab
President, Chief Executive Officer and Director
(Principal Executive Officer)

 
 
Exhibit 31.2

I, Justin Renz, certify that:

1.

I have reviewed this Annual Report on Form 10-K of Ardelyx, Inc.;

CERTIFICATION

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this
report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in

Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

(a)

(b)

(c)

(d)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to
ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with generally accepted accounting principles;

Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the
effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent
fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to
materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

(a)

(b)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are
reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal
control over financial reporting.

Date: February 22, 2024

By:

/s/ Justin Renz

Justin Renz
Chief Financial & Operations Officer
(Principal Financial Officer)

 
 
CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906
OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 32.1

In connection with the Annual Report of Ardelyx, Inc. (the “Company”) on Form 10-K for the period ending December 31, 2023, as filed with the
Securities and Exchange Commission on the date hereof (the “Report”), Michael Raab, President and Chief Executive Officer of the Company, and Justin
Renz, Chief Financial & Operations Officer of the Company, respectively, do each hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant
to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company.

Date: February 22, 2024

Date: February 22, 2024

By:

By:

/s/ Michael Raab

Michael Raab
President, Chief Executive Officer and Director
(Principal Executive Officer)

/s/ Justin Renz

Justin Renz
Chief Financial & Operations Officer
(Principal Financial Officer)

 
 
 
 
Exhibit 97.1

POLICY FOR RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION

ARDELYX, INC.

Ardelyx,  Inc.  (the  “Company”)  has  adopted  this  Policy  for  Recovery  of  Erroneously  Awarded  Compensation  (the
“Policy”), effective as of October 2, 2023 or such later date when Listing Rule 5608 of the Nasdaq Stock Market (“Nasdaq”)
becomes effective (the “Effective Date”). Capitalized terms used in this Policy but not otherwise defined herein are defined in
Section 11.

1.

Persons Subject to Policy

This Policy shall apply to current and former Officers of the Company.

2.    Compensation Subject to Policy

This  Policy  shall  apply  to  Incentive-Based  Compensation  received  on  or  after  the  Effective  Date.  For  purposes  of  this
Policy, the date on which Incentive-Based Compensation is “received” shall be determined under the Applicable Rules, which
generally  provide  that  Incentive-Based  Compensation  is  “received”  in  the  Company’s  fiscal  period  during  which  the  relevant
Financial Reporting Measure is attained or satisfied, without regard to whether the grant, vesting or payment of the Incentive-
Based Compensation occurs after the end of that period.

3.    Recovery of Compensation

In the event that the Company is required to prepare a Restatement, the Company shall recover, reasonably promptly, the
portion of any Incentive-Based Compensation that is Erroneously Awarded Compensation, unless the Committee has determined
that  recovery  would  be  Impracticable.  Recovery  shall  be  required  in  accordance  with  the  preceding  sentence  regardless  of
whether the applicable Officer engaged in misconduct or otherwise caused or contributed to the requirement for the Restatement
and  regardless  of  whether  or  when  restated  financial  statements  are  filed  by  the  Company.  For  clarity,  the  recovery  of
Erroneously  Awarded  Compensation  under  this  Policy  will  not  give  rise  to  any  person’s  right  to  voluntarily  terminate
employment  for  “good  reason,”  or  due  to  a  “constructive  termination”  (or  any  similar  term  of  like  effect)  under  any  plan,
program or policy of or agreement with the Company or any of its affiliates.

4.    Manner of Recovery; Limitation on Duplicative Recovery

The Committee shall, in its sole discretion, determine the manner of recovery of any Erroneously Awarded Compensation,
which may include, without limitation, reduction or cancellation by the Company or an affiliate of the Company of Incentive-
Based Compensation or Erroneously Awarded Compensation, reimbursement or repayment by any person subject to this Policy
of  the  Erroneously  Awarded  Compensation,  and,  to  the  extent  permitted  by  law,  an  offset  of  the  Erroneously  Awarded
Compensation  against  other  compensation  payable  by  the  Company  or  an  affiliate  of  the  Company  to  such  person.
Notwithstanding  the  foregoing,  unless  otherwise  prohibited  by  the  Applicable  Rules,  to  the  extent  this  Policy  provides  for
recovery  of  Erroneously  Awarded  Compensation  already  recovered  by  the  Company  pursuant  to  Section  304  of  the  Sarbanes-
Oxley Act of 2002 or Other Recovery Arrangements, the amount of Erroneously Awarded Compensation already recovered by
the Company from the recipient of such

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Erroneously  Awarded  Compensation  may  be  credited  to  the  amount  of  Erroneously  Awarded  Compensation  required  to  be
recovered pursuant to this Policy from such person.

5.    Administration

This  Policy  shall  be  administered,  interpreted  and  construed  by  the  Committee,  which  is  authorized  to  make  all
determinations necessary, appropriate or advisable for such purpose. The Board of Directors of the Company (the “Board”) may
re-vest in itself the authority to administer, interpret and construe this Policy in accordance with applicable law, and in such event
references  herein  to  the  “Committee”  shall  be  deemed  to  be  references  to  the  Board.  Subject  to  any  permitted  review  by  the
applicable national securities exchange or association pursuant to the Applicable Rules, all determinations and decisions made by
the  Committee  pursuant  to  the  provisions  of  this  Policy  shall  be  final,  conclusive  and  binding  on  all  persons,  including  the
Company and its affiliates, equityholders and employees. The Committee may delegate administrative duties with respect to this
Policy to one or more directors or employees of the Company, as permitted under applicable law, including any Applicable Rules.

6.    Interpretation

This Policy will be interpreted and applied in a manner that is consistent with the requirements of the Applicable Rules,
and  to  the  extent  this  Policy  is  inconsistent  with  such  Applicable  Rules,  it  shall  be  deemed  amended  to  the  minimum  extent
necessary to ensure compliance therewith.

7.    No Indemnification; No Liability

The  Company  shall  not  indemnify  or  insure  any  person  against  the  loss  of  any  Erroneously  Awarded  Compensation
pursuant to this Policy, nor shall the Company directly or indirectly pay or reimburse any person for any premiums for third-party
insurance policies that such person may elect to purchase to fund such person’s potential obligations under this Policy. None of
the Company, an affiliate of the Company or any member of the Committee or the Board shall have any liability to any person as
a result of actions taken under this Policy.

8.    Application; Enforceability

Except as otherwise determined by the Committee or the Board, the adoption of this Policy does not limit, and is intended
to  apply  in  addition  to,  any  other  clawback,  recoupment,  forfeiture  or  similar  policies  or  provisions  of  the  Company  or  its
affiliates, including any such policies or provisions of such effect contained in any employment agreement, bonus plan, incentive
plan, equity-based plan or award agreement thereunder or similar plan, program or agreement of the Company or an affiliate or
required under applicable law (the “Other Recovery Arrangements”). The remedy specified in this Policy shall not be exclusive
and shall be in addition to every other right or remedy at law or in equity that may be available to the Company or an affiliate of
the Company.

9.    Severability

The provisions in this Policy are intended to be applied to the fullest extent of the law; provided, however, to the extent
that any provision of this Policy is found to be unenforceable or invalid under any applicable law, such provision will be applied
to the maximum extent

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permitted,  and  shall  automatically  be  deemed  amended  in  a  manner  consistent  with  its  objectives  to  the  extent  necessary  to
conform to any limitations required under applicable law.

10.    Amendment and Termination

The Board or the Committee may amend, modify or terminate this Policy in whole or in part at any time and from time to
time in its sole discretion. This Policy will terminate automatically when the Company does not have a class of securities listed
on a national securities exchange or association.

11.    Definitions

    “Applicable Rules” means Section 10D of the Exchange Act, Rule 10D-1 promulgated thereunder, the listing rules of Nasdaq,
and  any  applicable  rules,  standards  or  other  guidance  adopted  by  the  Securities  and  Exchange  Commission  or  Nasdaq  (or  any
other national securities exchange or association that the Company has a class of its securities listed).

“Committee”  means  the  committee  of  the  Board  responsible  for  executive  compensation  decisions  comprised  solely  of
independent  directors  (as  determined  under  the  Applicable  Rules),  or  in  the  absence  of  such  a  committee,  a  majority  of  the
independent directors serving on the Board.

“Erroneously  Awarded  Compensation”  means  the  amount  of  Incentive-Based  Compensation  received  by  a  current  or
former  Officer  that  exceeds  the  amount  of  Incentive-Based  Compensation  that  would  have  been  received  by  such  current  or
former  Officer  based  on  a  restated  Financial  Reporting  Measure,  as  determined  on  a  pre-tax  basis  in  accordance  with  the
Applicable Rules.

“Exchange Act” means the Securities Exchange Act of 1934, as amended.

“Financial  Reporting  Measure”  means  any  measure  determined  and  presented  in  accordance  with  the  accounting
principles used in preparing the Company’s financial statements, and any measures derived wholly or in part from such measures,
including GAAP, IFRS and non-GAAP/IFRS financial measures, as well as stock or share price and total equityholder return.

“GAAP” means United States generally accepted accounting principles.

“IFRS” means international financial reporting standards as adopted by the International Accounting Standards Board.

“Impracticable”  means  (a)  the  direct  costs  paid  to  third  parties  to  assist  in  enforcing  recovery  would  exceed  the
Erroneously  Awarded  Compensation;  provided  that  the  Company  (i)  has  made  reasonable  attempts  to  recover  the  Erroneously
Awarded Compensation, (ii) documented such attempt(s), and (iii) provided such documentation to the relevant listing exchange
or association, (b) to the extent permitted by the Applicable Rules, the recovery would violate the Company’s home country laws
pursuant to an opinion of home country counsel; provided that the Company has (i) obtained an opinion of home country counsel,
acceptable  to  the  relevant  listing  exchange  or  association,  that  recovery  would  result  in  such  violation,  and  (ii)  provided  such
opinion to the relevant listing exchange or association, or (c) recovery would

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likely cause an otherwise tax-qualified retirement plan, under which benefits are broadly available to employees of the Company,
to fail to meet the requirements of 26 U.S.C. 401(a)(13) or 26 U.S.C. 411(a) and the regulations thereunder.

“Incentive-Based  Compensation”  means,  with  respect  to  a  Restatement,  any  compensation  that  is  granted,  earned,  or
vested based wholly or in part upon the attainment of one or more Financial Reporting Measures and received by a person: (a)
after  beginning  service  as  an  Officer;  (b)  who  served  as  an  Officer  at  any  time  during  the  performance  period  for  that
compensation; (c) while the Company has a class of its securities listed on a national securities exchange or association; and (d)
during the applicable Three-Year Period.

“Officer” means each person who serves as an executive officer of the Company, as defined in Rule 10D-1(d) under the

Exchange Act.

“Restatement”  means  an  accounting  restatement  to  correct  the  Company’s  material  noncompliance  with  any  financial
reporting requirement under securities laws, including restatements that correct an error in previously issued financial statements
(a) that is material to the previously issued financial statements or (b) that would result in a material misstatement if the error
were corrected in the current period or left uncorrected in the current period.

“Three-Year Period” means, with respect to a Restatement, the three completed fiscal years immediately preceding the
date that the Board, a committee of the Board, or the officer or officers of the Company authorized to take such action if Board
action  is  not  required,  concludes,  or  reasonably  should  have  concluded,  that  the  Company  is  required  to  prepare  such
Restatement, or, if earlier, the date on which a court, regulator or other legally authorized body directs the Company to prepare
such  Restatement.  The  “Three-Year  Period”  also  includes  any  transition  period  (that  results  from  a  change  in  the  Company’s
fiscal  year)  within  or  immediately  following  the  three  completed  fiscal  years  identified  in  the  preceding  sentence. However,  a
transition  period  between  the  last  day  of  the  Company’s  previous  fiscal  year  end  and  the  first  day  of  its  new  fiscal  year  that
comprises a period of nine to 12 months shall be deemed a completed fiscal year.

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