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Centene
Annual Report 2021

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FY2021 Annual Report · Centene
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2021 Annual Review

CENTENE CORPORATION

1

CENTENE CORPORATION

Centene Corporation, a Fortune 25 

company, is a leading multi-national 

healthcare enterprise that is committed to 

helping people live healthier lives.  

The Company takes a local approach —  

with local brands and local teams —  

to provide fully integrated, high-quality, 

and cost-effective services to government-

sponsored and commercial healthcare 

programs, focusing on under-insured and 

uninsured individuals. Centene offers 

affordable and high-quality products to 

nearly 1 in 15 individuals across the nation, 

including Medicaid and Medicare members 

(including Medicare Prescription Drug 

Plans) as well as individuals and families 

served by the Health Insurance 

Marketplace, the TRICARE program, and 

individuals in correctional facilities. 

The Company also serves several 

international markets, and contracts  

with other healthcare and commercial 

organizations to provide a variety of 

specialty services focused on treating  

the whole person. Centene focuses on 

long-term growth and value creation as  

well as the development of its people, 

systems, and capabilities so that it can 

better serve its members, providers, local 

communities, and government partners.

TABLE OF CONTENTS

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2 
5  
6 
7 
8 
10 
12 
14 
17 
18 
20 

2021 at a Glance
Letter from the Chief Executive Officer
Message from the Acting Chairman of the Board
Company and Financial Summary
Noteworthy Recognitions and Awards
Message from the Vice Chairman
Improving Health Outcomes
Message from the President and Chief Operating Officer
Products and Presence
Board of Directors
Supplemental Information
Corporate Information

With more  
than 35 years 

of experience in  

managing the health  

needs of many of our most  

vulnerable populations,  

Centene continues to pioneer  

innovative approaches to care. 

As we work to shape a better 

world of healthcare, we do so 

with a strong sense of  

responsibility for the value we 

provide to our communities. 

2021 AT A GLANCE 

26.6M 

Members

$126B 

In total revenues 

$4.2B 

Total operating cash flow

$2.

28

Diluted earnings per s

hare

$5.15 

Adjusted diluted earnings per share 

CENTENE CORPORATION

1

Letter from the 
Chief Executive Officer

In 2021, Centene continued demonstrating the unique value we provide to the  
individuals and communities we serve — while navigating the challenges of the  
ongoing pandemic. We added capabilities in critical areas, such as mental health and 
telemedicine, to address the evolving needs of our members and providers. And we 
spurred COVID-19 vaccinations to protect the health of our members and their families, 
increasing access to these lifesaving inoculations in communities across the country. 

Moreover, Centene initiated its Value Creation Plan in 2021, which will enhance quality  
for our members and state partners and unlock the tremendous earnings potential of this 
company. 

The strength of our foundational principles is evident in our performance. We saw 
membership grow to 26.6 million, a 4% increase from 2020. Total revenues reached  
$126 billion, or 13% year-over-year growth. 

Our accomplishments last year were the result of Centene’s leadership, partnerships  
with state governments and community organizations, and, of course, the dedication  
of our nearly 72,500-person workforce.

CONTINUED LEADERSHIP IN GOVERNMENT-SPONSORED HEALTHCARE
Centene’s success is sustained by the platform we have built across government-
sponsored healthcare, including Medicaid, Medicare, and Marketplace offerings.  
Our scale and experience uniquely position us with the knowledge, skills, technology,  
and resources to best serve more than 26.6 million people — nearly 1 in 15 individuals 
across the U.S. 

Medicaid continues to represent Centene’s largest membership group. In 2021, we saw 
newly awarded contracts and reprocurements in markets including Arizona, Hawaii, 
Nevada, North Carolina, and Ohio. In each, our commitment to our local approach will 
ensure that we are responsive to members’ needs and to state governments seeking to 
improve health outcomes and healthcare affordability.

We remain optimistic regarding future Medicare growth in 2022 after seeing strong 
performance in our Medicare Advantage product in 2021. Our geographic expansion for 
2022 means our Medicare products, most of which are now offered under a newly 
relaunched Wellcare brand, are now available to an additional base of 5.3 million  
potential customers.

22

Letter from the Chief Executive Officer

For Marketplace, despite headwinds caused by the pandemic, we continue to see 
significant opportunity underscored by our innovative and diverse product offering.  
In 2021, we entered 274 new counties across 13 markets, including five new states: 
Kentucky, Louisiana, Nebraska, New Jersey, and Oklahoma. In 2022, our Ambetter  
product will be available in 49% of all U.S. counties.

In addition, we closed our acquisition of Magellan Health in early 2022, which is a  
key example of our commitment to meet our members’ needs. Through the addition  
of Magellan, we are investing in our specialty care capabilities while also focusing on 
improved integration of behavioral and physical health. As a result, we see a growth 
opportunity ahead as we further enhance our ability to provide comprehensive care to  
the most complex and vulnerable populations.

OUR VALUE CREATION PLAN 
As we look to 2022 and beyond, we have strong momentum. We are well-positioned  
for operational excellence, high-quality health outcomes, and member and provider 
satisfaction.

At 2021 investor meetings, our executive team unveiled an enterprise-wide Value  
Creation Plan that fully leverages our size and scale to unlock opportunities for enhanced 
profitability and margin expansion. This initiative will allow us to remain agile, foster a 
culture of continuous improvement, and drive excellence and innovation — ultimately 
creating greater value for all stakeholders. As a purpose-driven organization, our Value 
Creation Plan is fully aligned with enterprise-wide goals for improving quality of care and 
member experiences. I believe the overwhelmingly positive reception we have received 
from the investment community underscores the strength of our management team, as 
well as our strategic vision for long-term success.

We have already begun executing our Value Creation Plan, which extends our leadership 
position in core markets while accelerating earnings. There are numerous levers to drive 
margin expansion that will yield significant results, particularly in 2023 and 2024. 
Ultimately, our Value Creation Plan will touch every part of our business and represents  
an ongoing evolution of how we operate.

CONTINUED COMMITMENT TO IMPROVING SOCIAL OUTCOMES
We continue to make social outcomes and health equity enterprise-wide goals. In 2021,  
we prioritized COVID-19 vaccination education and access for our members through a 
series of initiatives and partnerships, including an extensive outreach campaign and a 
partnership with the Pro Football Hall of Fame that created public service announcements 
targeting diverse communities.

Our commitment to addressing social determinants of health was seen in numerous 
initiatives across the country. Such initiatives included a pilot program in Arizona that 
targets social isolation by connecting high-risk members with an app that uses a chatbot 
to decrease loneliness and to connect users who may need help with housing or 
transportation, for example, with community-based resources.

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CENTENE CORPORATIONOur ability to effect positive change in our communities comes from within and from our 
deeply held belief in diversity, equity, and inclusion. We are pleased to be among the top 
scorers in the Human Rights Campaign Corporate Equality Index, as well as the Disability 
Equality Index, sponsored by the joint initiative of the American Association of People with 
Disabilities and Disability:IN. Centene was also recognized by U.S. Veterans Magazine as a 
“Best of the Best” top veteran-friendly company for the second year in a row, and was 
named a “Best Place to Work for LGBTQ Equality” by the Human Rights Campaign 
Foundation for the fourth consecutive year. 

ENHANCED CORPORATE GOVERNANCE AND LEADERSHIP PLANNING
In 2021, we announced enhancements to Centene’s governance as part of our ongoing 
review and Board of Directors refreshment processes. Recent appointments of directors 
include Kenneth “Ken” Burdick, Christopher Coughlin, Wayne DeVeydt, Sarah London, 
Leslie Norwalk, and Theodore “Ted” Samuels. In February of 2022, James Dallas was 
appointed Acting Chairman of the Board, and will assume the role of Independent 
Chairman this year. 

As we welcome these new members, the entire board is working to ensure Centene is  
best positioned to sustain our strong momentum in the years ahead. Throughout 2021, we 
continued to prioritize succession planning to ensure that Centene has the right leadership 
in place for continued success. With my imminent retirement, which I announced in 
December would take place in 2022, the Board of Directors is currently undergoing a 
thorough selection process for a new CEO and expects to appoint a new leader in Q2 2022.

As part of that process, in February 2022, we announced the expansion of the Office of the 
Chairman, which is made up of Vice Chairman Sarah London, President and Chief Operating 
Officer Brent Layton, Chief Financial Officer Drew Asher, and Chief Administrative Officer 
Shannon Bagley. 

I am highly confident that the company is in great hands with a capable management team 
focused on executing Centene’s strategy for profitable growth and serving our members 
with the highest quality of care.

MOVING CENTENE FORWARD
It has been one of the greatest privileges of my life to serve as CEO of Centene for more 
than 25 years. Nothing has been more important to me than providing the highest quality 
of care to the most vulnerable populations. 

In 1996, when I started as CEO, Centene served just three counties across two states, with 
$40 million in revenue. Today, Centene is a market leader with 2021 revenues of $126 
billion — ranking 24th nationally on the Fortune 500® list and 57 on the Fortune Global 
500® list.

I want to thank all of our Centene employees, both past and present, for what we have 
achieved together. Our employees have worked tirelessly for our members, and their 

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Letter from the Chief Executive Officer

dedication has not wavered even throughout recent global upheavals. I am immensely 
proud of each employee's role in building Centene into the company it is today. I also want 
to thank our shareholders for believing in our company and our ability to deliver value. 

Centene is a unique organization that has been guided by our purpose, culture, and values 
to become the leader in government-sponsored healthcare — and I have never been more 
confident in the future success of this company.

MICHAEL NEIDORFF
MICHAEL NEIDORFF
MICHAEL NEIDORFF
MICHAEL NEIDORFF
Chief Executive Officer

Message from the Acting Chairman of the Board

As the Acting Chairman of the Board of Centene, I want to express my deep gratitude, 
on behalf of the entire organization, for Michael's exceptional leadership over the 
past 25 years. 

Michael has played an instrumental role in growing the company to what it is today — 
one of the largest managed healthcare companies in the country with a presence in all 
50 states and over 72,500 employees. Michael has also instilled in our entire organization 
a purpose to provide high-quality, low-cost health care to the most vulnerable 
populations — a mission that serves as Centene's North Star. 

Under Michael's stewardship, he has established a strong foundation across Medicaid, 
Medicare and Marketplace. He has also successfully implemented a strategy to leverage 
Centene's size and scale and unlock significant value for all of our stakeholders.  

As we look forward, through 2022 and beyond, I am confident in the breadth and depth of 
our strong senior leadership team to further execute on this strategy and ensure Centene 
continues to play a leading role in transforming healthcare and the communities we serve. 

JAMES DALLAS
Acting Chairman of the Board

CENTENE CORPORATION

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Company and Financial Summary
(in millions) 

Total Revenues 

Net Earnings(1) 

2021 

2020 

2019 

2018 

2017

$125,982 

$111,115 

$74,639 

$60,116 

$48,382 

$1,347 

$1,808 

$1,321 

$900 

$828 

$889 

Adjusted Net Earnings(1) 

$3,040 

$2,896 

$1,857 

$1,411 

Total Assets 

$78,375  

$68,719 

$40,994 

$30,901 

$21,855 

TOTAL 
REVENUES
(in millions)

NET 
EARNINGS(1)
(in millions)

MANAGED 
CARE
MEMBERSHIP
(in thousands)

2021

2020

2019

2018

2017

2021

2020

2019

2018

2017

2021

2020

2019

2018

2017

$125,982

 $111,115

$74,639

$60,116

$48,382

$1,347

$1,321

$1,808

 26,611

 25,523

$900

$828

15,242

14,171

12,207

(1) Attributable to Centene Corporation

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Company and Financial Summary

 
 
 
Noteworthy Recognitions and Awards

Centene continues to gain global recognition for our 
leadership in a number of key areas, including our 
commitment to diversity, equity, and inclusion.   

Great Place to Work:
In 2021, Centene was certifi ed a Great Place to 
Work® based on our employee experience and our 
. 
people-first workplace culture

DiversityInc Top 50 Companies 
for Diversity:
For the second consecutive year, Centene was 
named a Top 50 Company for Diversity by 
DiversityInc, placing #36 in 2021. This represents a 
climb of 13 spots from 2020.  

Human Rights Campaign Corporate 
Equality Index  — Best Places to Work
for LGBTQ Equality:
Centene earned a score of 100 on the benchmarking 
report that measures corporate policies and practices 
related to LGBTQ workplace equality.

NO.

24

NO.

57

Ranked #24 on Fortune 500 List (2021):
Centene ranked #24 on the 2021 FORTUNE 500® list of 
largest U.S. corporations by revenue, up from #42 in 2020. 
Centene has continued to rapidly climb the list since its 
 first appearance, in 2010.

Ranked #57 on Fortune Global 500 List 
(2021):
Centene ranked #57 on the FORTUNE Global 500 list, up 
from #127 in 2020. This year marked Centene’s sixth year 
on the list, which ranks the top 500 companies worldwide 
based on revenue.

Gender-Equality Index: 
Centene is listed on the Bloomberg 2021 
Gender-Equality Index for our strong dedication to 
gender equality and the advancement of women in 
the workplace.

Veterans Inclusion:
For the second year, U.S. Veterans Magazine
named Centene one of its Top Veteran-Friendly 
Companies, while Military Times ranked Centene 
#40 on its Best for Vets: Employers list.

FORTUNE® World’s Most Admired Companies 
(2022):
For the fourth consecutive year, Centene was selected as 
one of Fortune's World's Most Admired CompaniesTM, 
a recognition bestowed by industry executives, directors, 
and analysts asked to rate enterprises in their own industry 
on nine criteria, from investment value and quality of 
management and products to social responsibility and 
ability to attract talent.

Disability Equality:
For the fourth consecutive year, Centene as a 
recognized with a 100% score on the Disability 
Equality Index (DEI), as one of the Best Places to 
Work for People with Disabilities, and named a 
Leading Disability Employer by the National
Organization on Disability (NOD).

Modern Healthcare Top Organization for Diversity:
Modern Healthcare magazine recognized Centene for our commitment 
to expanding and improving access to care, regardless of the race, 
ethnicity, gender, or sexual orientation of those we serve. Centene was 
also spotlighted for our efforts to increase diversity within our
workforce, including leadership and governance.

From FORTUNE, ©2021 FORTUNE Media IP Limited. FORTUNE and The World's Most Admired Companies are 
registered trademarks of Fortune Media IP Limited and are used under license. FORTUNE and Fortune 
Media IP Limited are not affi  liated with, and do not endorse the products or services of, Centene Corporation.

CENTENE CORPORATION

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Message from the Vice Chairman

SARAH LONDON
Vice Chairman

As Vice Chairman of Centene, I have the opportunity to work across our enterprise to set 
the overall strategy for the company. Our successful performance in 2021 amid a highly 
dynamic COVID-19 environment highlighted the strength of Centene’s core platform of 
capabilities combined with our ability to quickly address community health challenges. 
This past year certainly proved to be an important inflection point in our history.  
And while the entire world adjusts to a new normal, I believe Centene is more than 
prepared to continue leading.

Entering 2022, we are hard at work executing a detailed road map to unlock significant 
value for the next chapter of Centene. Strategic initiatives to grow our core businesses — 
Medicaid, Medicare, and Marketplace — are at the heart of our forward-looking plan. As  
we diligently manage this strategic process, we know that the keys to our plan for 
sustainable, profitable growth center on making the wisest use of our scale, position,  
and differentiated capabilities. 

It is through this lens that we revealed our Value Creation Plan, and our strategy for 
execution is clear, with targeted initiatives in motion across Centene today. Our plan is 
supported by a multiyear financial framework to help drive improved performance and 
results: SG&A expense savings, gross margin expansion, and strategic capital allocation.

::   On SG&A, initiatives are aimed at improving productivity, driving efficiencies, and 

reducing costs across the organization. This includes opportunities to regionalize or 
centralize certain functions — better supporting our health plans while continuing our 
strong commitment to our unique, local approach.

:: 

:: 

 The second area is gross margin expansion, which we expect to yield from both 
medical expense improvement and broader gross margin performance improvements. 

 Our third and final area of value creation is the strategic use of capital, which 
includes investing in our business, managing debt, and using free cash flow and 
proceeds from divestitures toward share repurchases. 

Furthermore, a critical component of Centene’s Value Creation Plan is a comprehensive 
review of our non-core assets as part of our ongoing portfolio optimization process. This 
review involves a thorough examination of financial potential, value to our core products, 
and relevance to our long-term strategy.

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Message from the Vice Chairman

 
 
Of course, an extremely important component of our vision for the future is Centene’s 
pioneering use of technology and a modern, digital infrastructure designed around closing 
the gap between health and care. Our strategic plan involves putting our machine learning, 
artifi cial intelligence, human-centered design, and advanced technology platforms to work 
— reimagining how we empower members to make better decisions along their care 
journey.

Across every corner of our enterprise, we are committed to delivering increased value to 
all of our stakeholders. As we build on Centene’s strong foundation and strategic 
investments in technology and innovation, we’re seizing opportunities to enhance our 
operations by creating a more seamless and efficient organization that delivers unrivaled 
member and provider experiences. Even as we transform, we remain absolutely steadfast 
in our determination to deliver high-quality, affordable care with dignity to the most 
vulnerable members of our community.

Looking ahead, I couldn’t be more energized by the opportunities that I see ahead for 
Centene. And I know I’m not alone. Our entire leadership team is motivated and unified by 
our vision for the future of this company and our ambition to shape a better world of 
healthcare. We are grateful for your support as we continue working to transform our 
communities and the healthcare experience for each and every one of our valued members.

SARAH LONDON
Vice Chairman

Centene's pioneering digital 
transformation is focused 
on closing the gap 
between health and care.

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Improving Health Outcomes

Through strategic, meaningful investments in data and 
technology, as well as the strong local focus of our community-
based teams, Centene is helping more members than ever  
receive the care they need, when and how they need it. 

NEST: Using more than 200 geodemographic characteristics  
as inputs, Centene created a predictive model known as NEST 
(Neighborhood, Environment, and Social Traits), which, supported 
by artificial intelligence, enables us to more proactively address 
risks and barriers to health that impact our members and the 
community as a whole, such as access to the COVID-19 vaccine 
and other necessary care.

OpiEnd: Centene’s substance use disorder model provides a 
98% accuracy rate in identifying potentially dangerous disorders 
and allows our teams to quickly connect individuals to the 
appropriate interventions.

Start Smart for Your Baby: Utilizing machine learning  
to identify pregnant members who are at high risk for a poor 
pregnancy outcome, our Start Smart for Your Baby predictive 
model has led to a 70% increase in the prediction of  
low-birth-weight babies. Our program reduces pregnancy 
complications, preterm and lower-birth-weight deliveries, and 
infant disease for our members, and can allow moms and babies 
to get home earlier. The program’s success leads to shorter 
hospital stays and outcome improvement and healthcare cost 
savings opportunity of more than $55 million.

Diabetes Care Management: Our diabetes predictive 
model has a 93% accuracy rate in identifying members likely to 
have uncontrolled diabetes, enabling our local care managers to 
outreach to members in need and develop a care plan for 
controlling diabetes.

10

Improving Health Outcomes

TECHNOLOGY EMPOWERING 
ENHANCED CARE 
As the model for delivering, 
receiving, and accessing timely and 
appropriate care continues to 
radically change, Centene remains 
at the forefront of the digital 
transformation, building and 
utilizing the latest technology and 
partnering with leaders inside the 
tech industry to shape the future  
of healthcare.

One example of our initiatives is our 
partnership with AT&T, Connected 
Nation, Dell Technologies, and Intel 
to create the K-12 Digital Divide 
Program, enabling greater internet 
access for youth in foster care. 
Centene and the other groups 
donated more than 1,000 laptops 
and 2,200 hotspots to foster care 
agencies in Florida and Missouri.

Additionally, Centene is creating new 
ways to streamline tasks for our 
team members — allowing them to 
focus more on supporting our 
members and providers. The 
Centene Authorization Digital 
Assistant uses machine learning to 
enable us to review millions of data 
records in little time, accelerating 
approval of authorization requests 
that can help members get the care 
they need quicker. In three pilot 
markets in 2021, CADA helped 
reduce clinical work by 67%, 
boosting efficiencies while cutting 
administrative costs. 

COVID-19: The scale and durability of Centene’s 
response to the COVID-19 pandemic is vast, varied, and 
ongoing. Initiatives delivering immediate resources to local 
communities, combined with long-lasting investments, will 
assist our workforce, provider network, community 
partners, and members for years to come.

:: 

:: 

:: 

 Centene health plans launched a nationwide Member 
Access Campaign, hosting or working with partners to 
hold more than 300 vaccination and COVID-19 testing 
events, providing nearly 272,000 vaccinations.

 Our health plans encouraged members to update their 
current vaccination status and provided assistance in 
accessing and scheduling vaccines for members.

 Our partnership with the Pro Football Hall of Fame aimed 
to increase education and awareness around vaccination 
through a series of public service announcements. The 
PSAs aired on national television networks and digital 
platforms, focusing particularly on communities of color.

:: 

 Centene joined the Lyft Vaccine Alliance, which provided 
60 million rides to and from vaccination sites for people  
in low-income, uninsured, and at-risk communities.

Centene continues to be at 
the forefront of helping our 
communities through the 
COVID-19 pandemic.

STEADFASTLY COMMITTED TO ENVIRONMENTAL, 
SOCIAL, AND CORPORATE RESPONSIBILITY
Transforming the health of our communities requires 
protecting and nurturing our environment, adhering to strict 
corporate governance, and addressing and removing social 
barriers that may prevent individuals and families from 
accessing the care they need. Learn more in our 
Environmental, Social, Health, and Governance 
Report to the Community available at www.centene.com/
who-we-are/corporate-facts-reports.html

DEI IS IN OUR DNA
Since our founding in 1984, diversity, equity, and inclusion 
have been part of the foundation of our company. Learn more 
about how we’re working with our communities to address 
societal challenges and provide targeted, culturally  
competent care to our members in our 2021 C-Index report 
at http://www.centene.com/who-we-are/corporate-facts-
reports.html

CENTENE CORPORATION

11

Message from the President and  
Chief Operating Officer

BRENT LAYTON
President and Chief Operating Officer

I'm pleased to report that Centene's core businesses continue producing strong results 
— thanks to the underlying, principled ways we serve individuals and communities that 
are far too often left behind.

By building upon our distinctive, local approach, we've grown to support members  
across the country. In the past five years alone, we've more than doubled our Medicaid 
membership from nearly 6.9 million to more than 15 million, which includes managed  
care services for Temporary Assistance for Needy Families (TANF), Medicaid Expansion, 
Children's Health Insurance Program (CHIP), Foster Care, Behavioral Health, Aged, Blind 
and Disabled (ABD), Intellectual and Developmental Disabilities (IDD), Long Term Services 
& Supports (LTSS), and Medicare-Medicaid Plan (MMP) Duals members.

Our partnership with federal and local governments to provide individuals and families 
with access to quality healthcare coverage expanded through our Health Insurance 
Marketplace products. Centene has consistently led the way since these insurance 
exchanges were introduced in 2014. Today, despite increasing competition, we continue to 
be the No. 1 provider of Marketplace health insurance. Entering 2022, we have expanded 
our geographic footprint and introduced new Marketplace products, designed to optimize 
flexibility, access, and affordability, that will continue to drive growth and meet our 
members' needs.

The acquisition of WellCare in 2020 continues to strengthen our position in Medicare. Our 
second year as a combined organization continued to build upon WellCare's product 
expertise and Centene's geographic footprint and provider relationships. This past year we 
unified our Medicare products under a refreshed national brand to build stronger brand 
awareness and better align with the company's strategy to transform and modernize how 
we engage with our members about their health. As we move into 2022, with an additional 
327 new counties, including counties in three new states, we feel confident about 
Centene's future in Medicare.

Centene's leadership position in government-sponsored healthcare is a responsibility we 
take very seriously. More than 26.6 million people and countless communities across the 
country depend on the high-quality healthcare solutions we deliver each day. That's why 
everything we do at Centene is built around serving the needs — and exceeding the 
expectations — of our members, providers, and state partners.

12

Message from the President and Chief Operating Officer

15

We take our leadership 
responsibility seriously — to 
increase access, improve 
quality, and reduce costs in 
healthcare.

The foundations of our business platform grow stronger as we enhance and streamline our 
operations to create additional value within our products. Above all else, we are driven by 
the dedication of our employees across the company to increase access, improve quality, 
and reduce costs in healthcare. The outlook for Centene is strong as we keep our eyes fixed 
on shaping the future of healthcare.

BRENT LAYTON
President and Chief Operating Officer

CENTENE CORPORATION

13

Products and Presence

15.0 million members
29 states 
67% of revenue

MEDICAID  
As the largest Medicaid managed care organization in the United States,  
Centene serves millions of low-income adults, children, pregnant women, and 
those with disabilities through our local health insurance companies across the 
country. Our Medicaid programs also provide tailored care options for specific 
populations, such as those who are blind or have a disability, children within  
and outside the foster care system, and adults and children who suffer from 
long-term or chronic illnesses or conditions.

In 2021, Centene expanded Medicaid offerings through newly awarded  
contracts and reprocurements in markets including Arizona, Hawaii,  
Nevada, North Carolina and Ohio.

2.1 million members
27 states 
1,480 counties
13% of revenue*

HEALTH INSURANCE MARKETPLACE  
Centene remains the leading insurer on the Health Insurance Marketplace,  
providing affordable healthcare solutions to individuals and families in more  
than 25 states and growing. Many of our Marketplace plans are offered through 
our Ambetter brand, a name that will gain in recognition in 2022, as we plan  
to expand into five new states and more than 250 new counties, making  
Ambetter available to individuals in 49% of U.S. counties.  

 1.3 million members
 36 states 
 1,575 counties
 14% of revenue**

MEDICARE ADVANTAGE  
Centene’s Medicare product offerings continue to grow, due in large part to  
our acquisition of WellCare in 2020. Following the acquisition, Centene made 
major strides to consolidate its Medicare products under a unified national 
brand. In 2022, Centene will expand its Medicare footprint by three new states 
and more than 325 new counties.

Geographic footprint depicted on these pages represents anticipated expansion 
throughout 2022. Marketplace expansion in 2022 includes LA, NE, NJ, OK, and 
KY. Medicare Advantage expansion in 2022 includes MA, NE, and OK.

* Revenue is total Commercial, which includes Health Insurance Marketplace.
**  Medicare revenue includes Prescription Drug Plans (PDPs). Centene offers PDPs 

in all 50 states and has 4.1 million members.

14

Products and Presence

 
 
ALASKA   HAWAII

ALASKA   HAWAII

ALASKA   HAWAII

CENTENE CORPORATION

15

 
 
Products and Presence (continued)

16

Products and Presence

CORRECTIONAL
Centene offers healthcare and staffing services to  
correctional systems and government agencies in nearly  
20 states through our national provider, Centurion Health.

ALASKA   HAWAII

TRICARE  
Managed by the Pentagon, TRICARE is the U.S. militaryʼs 
healthcare program, supporting active-duty families,  
National Guardsmen, and reservists and their families, as 
well as military retirees and their families. Partnering with 
the U.S. government, Centene offers TRICARE coverage  
in more than 20 states.

ALASKA   HAWAII

INTERNATIONAL  
Centene offers innovative and personalized solutions that 
close care gaps and improve health outcomes for  
international populations. In the United Kingdom, Circle 
Health Group is the largest independent hospital operator 
with 54 facilities and over 1.8 million patient visits per year. 
Operose Health is the leading provider of primary care 
services in the UK with customer-centric technological  
platforms, data analytics, and population management  
capabilities. Ribera Salud operates in both private  
healthcare and the fully integrated Accountable Care 
System sector, including research hospitals, primary care 
and outpatient clinics, and diagnostic centers in Spain and 
Central Europe. 

Board of Directors

Centene’s Board of Directors provides exceptional business and  
healthcare insight that has helped shape our corporate culture of  
accountability, ethics, and integrity. In 2021, Centene announced a 
number of enhancements as part of its ongoing board refreshment  
and governance review process.

Frederick H. Eppinger
President and Chief Executive Officer of  
Stewart Title Guaranty Company

Richard A. Gephardt
Chief Executive Officer and President of  
Gephardt Group, LLC; Former Majority Leader  
of the U.S. House of Representatives

Leslie V. Norwalk
Strategic Counsel to Epstein Becker & Green,  
P.C., EBG Advisors, Inc., and National  
Health Advisors

Lori J. Robinson
Retired United States Air Force General

Theodore Samuels
Retired President of Capital Guardian  
Trust Company

William L. Trubeck
Retired Chief Financial Officer, Director, and  
Executive Vice President of YRC Worldwide;  
Retired Executive Vice President and Chief 
Financial Officer of H&R Block 

Michael Neidorff
Chief Executive Officer of  
Centene Corporation

Sarah M. London
Vice Chairman, Centene Board of Directors

Orlando Ayala
Retired Chairman and Corporate  
Vice President of Emerging Businesses for 
Microsoft Corporation

Jessica L. Blume
Retired Vice Chairman of Deloitte LLP

Kenneth Burdick
Retired Executive Vice President of Products  
and Markets of Centene Corporation;  
Former Chief Executive Officer of WellCare 
Health Plans, Inc.

Christopher Coughlin
Former Executive Vice President and  
Chief Financial Officer of Tyco  
International, Ltd.

H. James Dallas
Acting Chairman of Centene Corporation; 
Retired Senior Vice President and  
Chief Information Officer of Medtronic

Wayne S. DeVeydt
Executive Chairman of Surgery Partners, Inc.; 
Former Executive Vice President and Chief 
Financial Officer of Anthem, Inc.

CENTENE CORPORATION

17

Supplemental Information

MEMBERSHIP
The following table sets forth our membership  
by line of business:

December 31

Traditional Medicaid(1)

High Acuity Medicaid(2)

    Total Medicaid

Commercial

Medicare(3)

Medicare PDP

International

Correctional

    Total at-risk membership

TRICARE eligibles

Non-risk membership

    Total

The following table sets forth additional 
membership statistics, which are included  
in the membership information above:

Dual-eligible(4)

Health Insurance Marketplace

Medicaid Expansion

2021

13,328,400 

1,686,100   

15,014,500

2,602,600

1,252,200

4,070,500

597,600

194,500

23,731,900

2,874,700

4,000

26,610,600

1,178,000  

2,140,500

2,468,100

(1) Membership includes TANF, Medicaid Expansion, CHIP, Foster Care, and Behavioral Health.   
(2) Membership includes ABD, IDD, LTSS, and MMP Duals.
(3) Membership includes Medicare Advantage and Medicare Supplement.
(4) Membership that is eligible for both Medicaid and Medicare benefits.

2020

12,055,400 

 1,554,700

13,610,100

2,633,600

955,400

4,469,400

597,700

147,200

22,413,400

2,877,900

231,600

25,522,900

1,066,800  

2,131,600 

2,181,400 

18

Supplemental Information

                
 
 
 
OPERATING RATIOS

HBR

SG&A expense ratio

Adjusted SG&A expense ratio

HBR BY PRODUCT

2021

Medicaid

Commercial

Medicare(1)

Year Ended December 31

2021

87.8%

8.6%

8.4%

Full Year

88.1%

86.6%

87.1%

Q4 

89.0%

84.4%

86.3%

Q3

88.4%

88.7%

85.4%

Q2

88.1%

90.0%

87.6%

(1) Medicare includes Medicare Advantage, Medicare Supplement, and Medicare PDP.

2020

86.2%

9.5%

8.9%

Q1

87.1%

83.4%

88.9%

19

CENTENE CORPORATION 
Corporate Information

COMMON STOCK INFORMATION
Centene common stock is traded and quoted  
on the New York Stock Exchange under the 
symbol “CNC.” 

Stock 
Price

First 
Quarter

Second 
Quarter

Third 
Quarter
Fourth 
Quarter

        2022*

          2021

High

Low

High

Low

$86.81 $74.47

$70.26 $57.16

75.25 59.33

75.59 59.67

85.44 60.81

NON-GAAP FINANCIAL RECONCILIATIONS

Year Ended December 31 
(in millions, except per share data in dollars)

GAAP net earnings attributable to Centene

$1,347

$1,808

$1,321

$900

Amortization of acquired intangible assets

  Acquisition-related expenses

  Other adjustments(1)

770

185

 1,275

719

602

 29

258 

104 

301

211  

425  

30

2021

2020

2019

2018

2017

$828

156 

20 

(7)

Income tax effects of adjustments(2)

(537)

(262)

(127)

(155)

(108)

    Adjusted net earnings

$3,040

$2,896

$1,857

$1,411

889

GAAP diluted earnings per share (EPS)  
attributable to Centene

*Stock price through February 18, 2022

Amortization of acquired intangible assets(3)

Acquisition-related expenses(4)

  Other adjustments(5)

    Adjusted diluted EPS

ADJUSTED SG&A EXPENSE RATIO RECONCILIATION

GAAP SG&A expenses

Less:

Acquisition-related expenses

  Restructuring Costs

  Legal fees related to legal settlement

    Adjusted SG&A expenses

(1)   Other adjustments include the following items: 

$2.28

1.00

0.24

1.63

$5.15

$10,166

$9,867

157

54

14

580

 —

—

$9,941

$9,287

xpense and related legal fees of $1,264 million; debt extinguishment costs of $125 million; severance costs due to a 

2021 — legal settlement e
restructuring of $54 million; a reduction to the previously reported gain due to the finalization of the working capital adjustment related to the 
divestiture of certain products of our Illinois health plan of $62 million; non-cash gain related to the acquisition of the remaining 60% interest 
of Circle Health of $309 million; non-cash impairment of our equity method investment in RxAdvance of $229 million; and gain related to the 
divestiture of U.S. Medical Management (USMM) of $150 million

 2020 — gain related to the divestiture of certain products of our Illinois health plan of $104 million; non-cash impairment of our third-party 
care management software business of $72 million; and debt extinguishment costs of $61 million

  2019 — non-cash goodwill and intangible asset impairment of $271 million and debt extinguishment costs of $30 million

  2018 — the impact of retroactive changes to the California minimum medical loss ratio (MLR) of $30 million of expense

2017 — the Penn Treaty assessment expense of $56 million; the cost sharing reduction (CSR) expense of $22 million; (c) the charitable  
contribution commitment of $40 million; and the benefit associated with income tax reform of $125 million  

(2) The income tax effects of adjustments are based on the effective income tax rates applicable to each adjustment.

(3)   The amortization of acquired intangible assets per diluted share presented above is net of an income tax benefit of $0.31 for the twelve 

months ended December 31, 2021.

(4)  The acquisition-related expenses per diluted share presented above are net of an income tax benefit of $0.07 for the twelve months ended 

December 31, 2021.

(5)  Other adjustments for the year ended December 3

1, 2021, include the following items: legal settlement expense and related legal fees of $1.76 
per diluted share, net of an income tax benefit of $0.38; debt extinguishment costs of $0.16 per diluted share, net of an income tax benefit of 
$0.05; severance costs due to a restructuring of $0.06 per diluted share, net of an income tax benefit of $0.03; a reduction to the previously 
reported gain due to the finalization of the working capital adjustment related to the divestiture of certain products of our Illinois health plan 
of $0.08 per diluted share, net of an income tax benefit of $0.02; non-cash gain related to the acquisition of the remaining 60% interest of 
Circle Health of $0.52 per diluted share, net of income tax expense of $0.00; non-cash impairment of our equity method investment in RxAd-
vance of $0.32 per diluted share, net of an income tax benefit of $0.07; and gain related to the divestiture of USMM of $0.23 per diluted share, 
net of an income tax expense of $0.02.

20

Corporate Information

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
 
 
 
GAAP net earnings attributable to Centene

$1,347

$1,808

$1,321

$900

2021

2020

2019

2018

770

185

 1,275

719

602

 29

258 

104 

301

211  

425  

30

2017

$828

156 

20 

(7)

Income tax effects of adjustments(2)

(537)

(262)

(127)

(155)

(108)

    Adjusted net earnings

$3,040

$2,896

$1,857

$1,411

889

NON-GAAP FINANCIAL RECONCILIATIONS

  Amortization of acquired intangible assets

  Acquisition-related expenses

  Other adjustments(1)

GAAP diluted earnings per share (EPS)  

attributable to Centene

  Amortization of acquired intangible assets(3)

  Acquisition-related expenses(4)

  Other adjustments(5)

    Adjusted diluted EPS

GAAP SG&A expenses

Less:

  Acquisition-related expenses

  Restructuring Costs

  Legal fees related to legal settlement

    Adjusted SG&A expenses

$2.28

1.00

0.24

1.63

$5.15

$10,166

$9,867

157

54

14

580

 —

—

$9,941

$9,287

CORPORATE 
INFORMATION

Included in this 2021 Annual Review are financial 
and operating highlights and summary financial 
statements. For complete financial statements, 
including notes, please refer to Centene’s Annual 
Report on Form 10-K for the fiscal year ended 
December 31, 2021, filed with the Securities and 
Exchange Commission (the “2021 Form 10-K”), 
which also includes Management’s Discussion and 
Analysis of Financial Condition and Results of 
Operations. This 2021 Annual Review together with 
our 2021 Form 10-K constitute our annual report to 
security holders for purposes of Rule 14a-3(b) of 
the Securities Exchange Act of 1934, as amended. 
Our 2021 Form 10-K may be obtained by accessing 
the investor section of our company’s website at 
www.centene.com or by going to the SEC’s website 
at www.sec.gov.

NON-GAAP FINANCIAL PRESENTATION
The Company is providing certain non-GAAP 
financial measures in this report, as the Company 
believes that these figures are helpful in allowing 
investors to more accurately assess the ongoing 
nature of the Company’s operations and measure 
the Company’s performance more consistently 
across periods. The Company uses the presented 
non-GAAP financial measures internally to allow 
management to focus on period-to-period changes 
in the Company’s core business operations. 
Therefore, the Company believes that this 
information is meaningful in addition to the 
information contained in the GAAP presentation of 
financial information. The presentation of this 
additional non-GAAP financial information is not 
intended to be considered in isolation or as a 
substitute for the financial information prepared 
and presented in accordance with GAAP. 
Specifically, the Company believes the 
presentation of non-GAAP financial information 
that excludes amortization of acquired intangible 
assets, acquisition-related expenses, and other 
items allows investors to develop a more 
meaningful understanding of the Company’s 
performance over time.

FORM 10-K
Centene has filed an Annual Report on Form 10-K 
for the year ended December 31, 2021, with the 
Securities and Exchange Commission. Stockholders 
may obtain a copy of this report, without charge, 
by writing: 
Investor Relations 
Centene Corporation 
7700 Forsyth Boulevard 
St. Louis, MO 63105 
www.centene.com 

TRANSFER AGENT 
Broadridge Corporate Issuer Solutions, Inc. 
51 Mercedes Way 
Edgewood, NY 11717 
855-627-5087 
https://shareholder.broadridge.com/bcis/ 

ANNUAL MEETING
The Annual Meeting of Stockholders will be held  
on Tuesday, April 26, 2022, at 10 a.m. Central Time 
at Centene Plaza, 7700 Forsyth Boulevard,  
St. Louis, Missouri 63105.

ADJUSTED SG&A EXPENSE RATIO RECONCILIATION

CAUTIONARY STATEMENT ON FORWARD-LOOKING STATEMENTS OF CENTENE

All statements, other than statements of current or historical fact, contained in this communication are forward-looking statements. Without limiting the foregoing, forward-looking 
statements often use words such as "believe," "anticipate," "plan," "expect," "estimate," "intend," "seek," "target," "goal," "may," "will," "would," "could," "should," "can," "continue"  
and other similar words or expressions (and the negative thereof ). Centene (the Company, our, or we) intends such forward-looking statements to be covered by the safe-harbor provisions 
for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995, and we are including this statement for purposes of complying with these safe-harbor 
provisions. In particular, these statements include, without limitation, statements about our future operating or financial performance, market opportunity, value creation strategy, 
competition, expected activities in completed and future acquisitions, including statements about the impact of our recently completed acquisition of Magellan Health (the Magellan 
Acquisition), other recent and future acquisitions and dispositions, investments and the adequacy of our available cash resources. 

These forward-looking statements reflect our current views with respect to future events and are based on numerous assumptions and assessments made by us in light of our experience and 
perception of historical trends, current conditions, business strategies, operating environments, future developments and other factors we believe appropriate. By their nature, forward-
looking statements involve known and unknown risks and uncertainties and are subject to change because they relate to events and depend on circumstances that will occur in the future, 
including economic, regulatory, competitive and other factors that may cause our or our industry's actual results, levels of activity, performance or achievements to be materially different 
from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. These statements are not guarantees of future 
performance and are subject to risks, uncertainties and assumptions. All forward-looking statements included in this communication are based on information available to us on the date 
hereof. Except as may be otherwise required by law, we undertake no obligation to update or revise the forward-looking statements included in this communication, whether as a result of 
new information, future events or otherwise, after the date hereof. You should not place undue reliance on any forward-looking statements, as actual results may differ materially from 
projections, estimates, or other forward-looking statements due to a variety of important factors, variables and events including, but not limited to: our ability to accurately predict and 
effectively manage health benefits and other operating expenses and reserves, including fluctuations in medical utilization rates due to the impact of COVID-19; the risk that the election of 
new directors, changes in senior management and inability to retain key personnel may create uncertainty or negatively impact our ability to execute quickly and effectively; uncertainty as to 
the expected financial performance of the combined company following the recent completion of the Magellan Acquisition; the possibility that the expected synergies and value creation from 
the Magellan Acquisition or the WellCare Acquisition (or other acquired businesses) will not be realized, or will not be realized within the respective expected time periods; the risk that 
unexpected costs will be incurred in connection with the integration of the Magellan Acquisition or that the integration of Magellan Health will be more difficult or time consuming than 
expected, or similar risks from other acquisitions we may announce or complete from time to time; disruption from the integration of the Magellan Acquisition or from the integration of the 
WellCare Acquisition, or similar risks from other acquisitions we may announce or complete from time to time, including potential adverse reactions or changes to business relationships with 
customers, employees, suppliers or regulators, making it more difficult to maintain business and operational relationships; a downgrade of the credit rating of our indebtedness; competition; 
membership and revenue declines or unexpected trends; changes in healthcare practices, new technologies, and advances in medicine; increased healthcare costs; changes in economic, 
political or market conditions; changes in federal or state laws or regulations, including changes with respect to income tax reform or government healthcare programs as well as changes 
with respect to the Patient Protection and Affordable Care Act and the Health Care and Education Affordability Reconciliation Act (collectively referred to as the ACA) and any regulations 
enacted thereunder that may result from changing political conditions, the new administration or judicial actions; rate cuts or other payment reductions or delays by governmental payors 
and other risks and uncertainties affecting our government businesses; our ability to adequately price products; tax matters; disasters or major epidemics; changes in expected contract start 
dates; provider, state, federal, foreign and other contract changes and timing of regulatory approval of contracts; the expiration, suspension, or termination of our contracts with federal or 
state governments (including, but not limited to, Medicaid, Medicare, TRICARE or other customers); the difficulty of predicting the timing or outcome of legal or regulatory proceedings or 
matters, including, but not limited to, our ability to resolve claims and/or allegations made by states with regard to past practices, including at Envolve Pharmacy Solutions, Inc. (Envolve), as 
our pharmacy benefits manager (PBM) subsidiary, within the reserve estimate we have recorded and on other acceptable terms, or at all, or whether additional claims, reviews or 
investigations relating to our PBM business will be brought by states, the federal government or shareholder litigants, or government investigations; timing and extent of benefits from 
strategic value creation initiatives, including the possibility that these initiatives will not be successful, or will not be realized within the expected time periods; challenges to our contract 
awards; cyber-attacks or other privacy or data security incidents; the exertion of management's time and our resources, and other expenses incurred and business changes required in 
connection with complying with the undertakings in connection with any regulatory, governmental or third-party consents or approvals for acquisitions; changes in expected closing dates, 
estimated purchase price and accretion for acquisitions; the risk that acquired businesses will not be integrated successfully; restrictions and limitations in connection with our 
indebtedness; our ability to maintain or achieve improvement in the Centers for Medicare and Medicaid Services (CMS) Star ratings and maintain or achieve improvement in other quality 
scores in each case that can impact revenue and future growth; availability of debt and equity financing, on terms that are favorable to us; inflation; foreign currency fluctuations and risks 
and uncertainties discussed in the reports that Centene has filed with the Securities and Exchange Commission. This list of important factors is not intended to be exhaustive. We discuss 
certain of these matters more fully, as well as certain other factors that may affect our business operations, financial condition and results of operations, in our filings with the Securities and 
Exchange Commission (SEC), including our annual report on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K. Due to these important factors and risks, we cannot 
give assurances with respect to our future performance, including without limitation our ability to maintain adequate premium levels or our ability to control our future medical and selling, 
general and administrative costs.

 
 
 
 
 
7700 Forsyth Blvd.
St. Louis, MO 63105 U.S.A.

1-314-725-4477

www.centene.com