Quarterlytics / Financial Services / Asset Management / Cizzle Biotechnology Holdings Plc / FY2020 Annual Report

Cizzle Biotechnology Holdings Plc
Annual Report 2020

CIZ · LSE Financial Services
Claim this profile
Ticker CIZ
Exchange LSE
Sector Financial Services
Industry Asset Management
Employees 1-10
← All annual reports
FY2020 Annual Report · Cizzle Biotechnology Holdings Plc
Loading PDF…
Bould Opportunities PLC 

(to be renamed Cizzle Biotechnology Holdings PLC) 

Annual Report for the year ended 31 December 2020 

Company registered number: 06133765 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

Annual Report for the year ended 31 December 2020 

Contents 

Page 

Directors and Advisers  ................................................................................................................. 1 

Chairman’s Statement ................................................................................................................... 2 

Strategic Report ............................................................................................................................ 4 

Directors' Report  ........................................................................................................................... 5 

Corporate Governance Statement ................................................................................................ 8 

Independent Auditor’s report to the members of Bould Opportunities PLC  .............................. 14 

Statement of Comprehensive Income ......................................................................................... 18 

Statement of Financial Position ................................................................................................... 19 

Statement of Cash Flows ............................................................................................................ 20 

Statement of Changes in Equity ................................................................................................. 21 

Notes to the Financial Statements .............................................................................................. 22 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

1

Directors and Advisers 

Directors 

Allan Syms 
Nigel Lee 
Dawn Coverley 
John Treacy 
Martin Lampshire 

Company Secretary 

Executive Chairman  
Finance Director (appointed 14 May 2021) 
Non-Executive Director (appointed 14 May 2021) 
Non-Executive Director 
Non-Executive Director (resigned 13 May 2021) 

SGH Company Secretaries Limited (appointed 14 May 2021) 
CFO Solutions Limited  (resigned 14 May 2021)         

Registered Number 

06133765 

Registered Office  
c/o SGH Secretaries Limited 
6th Floor,  
60 Gracechurch Street, 
London 
EC3V 0HR 

Financial Adviser 
Allenby Capital Limited 
5 St. Helen’s Place 
London,  
EC3A 6AB 

Broker 
Novum Securities Limited 
8-10 Grosvenor Gardens, 
Belgravia, 
London  
SW1W 0DH   

Solicitors 
Goodman Derrick LLP 
10 St Bride Street 
London 
EC4A 4AD 

Auditor 
PKF Littlejohn LLP 
Statutory Auditor 
15 Westferry Circus 
London 
E14 4HD 

Registrar 
Link Group 
10th Floor, Central Square 
29 Wellington Street 
Leeds,  
LS1 4DL 

 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC)   

2

Chairman’s Statement 
I am pleased to report to you on the Company’s activities and developments in 2020 and in the year to 
date in 2021. 

Overview  
The Company has continued to prepare ‘Company only’ results as opposed to consolidated accounts for 
the  whole  Group.  It  was  announced  on  8  April  2020  that,  the  Company,  together  with  its  various 
professional  advisers,  was  working  to  complete  the  acquisition  of  a  company  (“the  Target  Company”) 
focused on early cancer detection (the “Proposed Transaction”). The Directors appreciated the concerns 
of shareholders regarding the delay in completing the Proposed Transaction. This was due to a lengthy 
process of listing the Company’s shares whilst undertaking work covering legal, financial and technical 
due diligence, followed by a lengthy review process and dialogue with the relevant regulatory bodies. The 
Covid-19 pandemic also hindered progress. 

I am pleased to note under ‘Post year end’ in my report below and also within the notes to the accounts 
that the Proposed Transaction completed on 14 May 2021. 

Business review 
As  can  be  seen  from  the  Directors  and  Advisors  section  on  page  1,  the  composition  of  the  board  of 
directors during 2020 has remained unchanged. Since the year end the composition of the board changed 
following the completion of the Proposed Transaction. The results of the Company’s operations are shown 
in  the  2020  Statement  of  Comprehensive  Income  which  has  been  prepared  in  accordance  with  IFRS 
accounting standards.  

Financial overview 

The Company’s total comprehensive loss for 2020 was £306,000 (2019: loss £832,000) after a loss on 
disposal of subsidiary companies of Nil (2019: £201,000) and Proposed Transaction expenses of £77,000 
(2019:  £275,000).  There  were  no  proceeds  from  the  issue  of  shares  in  2020  (2019:  Net  proceeds  of 
£1,206,000). The Company did not have any borrowings at 31 December 2020 (2019: £Nil). 

Post year end 

I  am  pleased  to  report  that  on  14  May  2021  the  Company  completed  the  acquisition  of  Cizzle 
Biotechnology Limited (“Cizzle Biotechnology”). The Company’s name is in the process of being changed 
to Cizzle Biotechnology Holdings plc and the Company’s shares were admitted to the Standard Listing 
segment  of  the  Official  List  and  to  trading  on  the  Main  Market  of  the  London  Stock  Exchange.  The 
Company’s  shares  began 
ticker  CIZ 
(ISIN:GB00BNG2VN02), initially under the name of Bould Opportunities plc until the change of name to 
Cizzle Biotechnology Holdings plc, approved by shareholders at a General Meeting on 13 May 2021, is 
effective. 

trading  at  8.00  a.m.  on  14  May  2021  under 

the 

Cizzle Biotechnology is in the early stages of developing a blood test for the early detection of a majority 
of the different forms of lung cancer. Its proof-of-concept prototype test is based on the ability to detect a 
stable plasma biomarker, a variant of C1Z1 known as CIZ1B. C1Z1 is a naturally occurring cell nuclear 
protein involved in DNA replication, and the targeted C1Z1B variant is highly correlated with early stage 
lung cancer. Peer-reviewed published research led by Professor Coverley has demonstrated that CIZ1B 
can be measured via an ELISA process, which should allow for testing in a high-throughput, hospital-
friendly  format.  The  Directors  believe  that  this  development  overcomes  an  important  barrier  to  further 
clinical development and the application of this blood test for the early detection of lung cancer, which is 
essential to improve a patient’s chance of survival.  

Cizzle  Biotechnology,  a  spin-out  from  the  University  of  York,  was  initially  funded  by  Yorkshire  Cancer 
Research,  White  Rose  Technology  Seed  Corn  Fund,  Finance  Yorkshire  Seedcorn  LLP  and  Viking 
Members, who with management, invested in the project to support the development of a prototype blood 
test.  The  business  was  founded  in  2006  by  Professor  Coverley,  a  cell  biologist  working  out  of  the 
University of York. Professor Coverley has 20 years’ experience in basic cancer-related research and is 
currently  principal  investigator  of  an  academic  DNA  replication  research  laboratory  at  York  and  Chief 
Scientific Officer of Cizzle Biotechnology. Cizzle Biotechnology’s current technology is based on the ability 
to detect the CIZ1B variant of this protein, which is a stable plasma biomarker that is highly correlated 
with the presence of lung cancer. Cizzle Biotechnology is seeking to develop and commercialise a simple 
blood test for the early detection of the main forms of lung cancer, ideally at a stage when the disease still 
bears a good prognosis. Cizzle Biotechnology’s goal is to produce a test that can provide results quickly 

 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

3 

and  accurately,  so  avoiding  the  need  for  intrusive  follow  up  testing,  which  can  include  repeated  CT 
scanning and/or tissue biopsies, which are both costly to the NHS, health providers and medical insurers 
and stressful to patients. The board intends the Company’s initial product to be a diagnostic immunoassay 
that can be readily performed by hospitals and reference laboratories, but a potential follow-on product 
could be a point of care test provided by a primary health care provider. 

The Company, following a share reorganisation, completed a placing of 22,000,000 new ordinary shares 
at 10p per share to raise gross proceeds of £2.2 million. The board intends to apply a majority of the net 
proceeds of the Placing towards the development of the C1Z1B biomarker test through to CE marking 
and/or FDA 510(k) clearance. 

Allan Syms 
Executive Chairman 
20 May 2021 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

4 

Strategic Report 

The directors present their strategic report for the year ended 31 December 2020. 

Business review 

The review of the Company is detailed on page 2 of the Chairman’s Statement. 

Principal risks and uncertainties 

The Company continued to be a Cash Shell seeking a new investment opportunity during 2020. Accordingly 
until the completion of the acquisition of Cizzle Biotechnology Limited on 14 May 2021, the principal risk of 
the Company was its going concern. The Company did not raise any funds in 2020 but raised £2.2m on 14 
May 2021 through the issue of 22,000,000 ordinary shares of 0.1p each at 10p per share. The Company 
received  £1,964,500  on  18  May  2021  after  settlement  of  some  of  the  professional  fees  relating  to  this 
transaction.  

The Company has prepared a working capital forecast until 31 March 2023 on the basis that the Reverse 
Takeover of the Target Company is completed, which subsequently was and is referred to in the Chairman’s 
Statement. As already mentioned in the Chairman’s Statement, the COVID-19 pandemic delayed the speed 
of completing the Proposed Transaction. Management will continue to assess the impact of COVID-19 on 
the Company.  

Key performance indicators (KPI's)  

During 2020 the focus of the directors has continued to be keeping the Company’s costs to a minimum and 
monitoring its cash flow forecasts to ensure that there  were sufficient funds in the Company in order to 
complete the Reverse Takeover of the Target Company. 
The Company’s total comprehensive loss for 2020 was £306,000 (2019: loss £832,000) after exceptional 
administrative expenses relating to the disposal of subsidiary companies of Nil (2019: £201,000) and costs 
of £77,000 (2019: £275,000) relating to the Proposed Transaction. Basic and the diluted loss per share 
were  0.0p  (2019:  0.0p).  In  2021  the  Company’s  focus  is  the  development  of  the  CIZ1B  biomarker  test 
through to CE marking and/or FDA 510(k) clearance.   

Promotion of the Company for the benefit of the Members as a whole 

S172 of the Companies Act 2006 requires the board to promote the Company for the benefit of the members 
as a whole. In particular, the requirements of s172 are for the Directors to:  

•  Consider the likely consequences of any decision in the long term,  

•  Act fairly between the members of the Company,  
•  Maintain a reputation for high standards of business conduct,  
•  Consider the interests of the Company’s employees,  

•  Foster the Company’s relationships with suppliers, customers and others, and  

•  Consider the impact of the Company’s operations on the community and the environment.  

The Directors believe that during the year they have acted in the way most likely to promote the success of 
the Company for the benefit of its members as a whole and have adhered to the requirements set out above 
that are applicable to the Company given its scope of operations.  For example, the Company, does not 
have any employees other than the directors, so considering employee interests is not relevant.  However, 
the  Company  has  been  focused  on  completing  the  Proposed  Transaction  to  benefit  the  Company’s 
members as a whole.  

This report was approved by the board on 20 May 2021 and was signed on its behalf by: 

Nigel Lee 
Director 

 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

5 

Directors’ Report for the year ended 31 December 2020 

The directors present the annual report and audited financial statements for the year ended 31 December 
2020. 

Principal activity, business review and future developments 

The  principal  activity  of  the  Company  during  the  year  was  that  of  a  holding  company  seeking  a  new 
investment  opportunity,  which  was  completed  on  14  May  2021  following  the  acquisition  of  Cizzle 
Biotechnology Limited.  

The Statement of Comprehensive Income is set out on page 18. A review of the Company’s trading during 
the year, its position at the year-end, post balance sheet events, and its prospects for the future are set out 
in the Chairman’s Statement and the Strategic Report. 

Dividends 

No dividend is proposed in respect of the year (2019: £nil). 

Financial risk management 

Information  in  respect  of  financial  risk  management  objectives  and  policies,  exposure  to  price,  credit, 
liquidity and cash flow risks, and current trading and trading outlook for the Company are outlined in Note 
3. 

Directors 

The directors of the Company who served during the year, as well as changes occurring during 2021, are 
listed below: 

Directors 

Function 

Allan Syms 
John Treacy 
Nigel Lee 
Dawn Coverley 
Martin Lampshire 

Non-Executive Chairman  
Non-Executive Director  
Finance Director (appointed 14 May 2021) 
Non – Executive Director (appointed 14 May 2021) 
Non-Executive Director (resigned 13 May 2021) 

Board Responsibility and Corporate Governance Statement 

The  board  is  responsible  for  approving  the  interim  and  annual  financial  statements,  formulating  and 
monitoring Company strategy, approving financial plans and reviewing performance, as well as complying 
with legal, regulatory and corporate governance matters. The board is committed to maintaining appropriate 
standards  of  corporate  governance  and,  as  detailed  below,  has  concluded  that  it  will  adopt  the  Quoted 
Companies Alliance’s Corporate Governance Code.   

Employees 

At 31 December 2020 the total number of employees in the Company comprised 3 employees (2019: 3), 
including 3 Directors (2019:3). 

The Company’s employment policies were designed to attract, retain and motivate the very best staff for 
each  role  in  the  Company,  recognising  that  this  can  only  be  achieved  through  equal  opportunities 
regardless of gender, race, religion or disability. Regular meetings were held with employees to discuss the 
performance of the Company as a whole and the area in which they work. Financial and economic factors 
were dealt with in this context. Information concerning employees and their remuneration is given in Note 
14. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

6 

Directors’ Report for the year ended 31 December 2020 (continued) 

Capital structure 

Details of the issued share capital are set out in Note 9. The shares in issue are New Ordinary Shares of 
0.01p nominal value and one Deferred ‘A’ Shares of 0.99p nominal value.  

The New Ordinary Shares has the right to one vote at general meetings of the Company. The Deferred 
‘A’ Shares do not have any voting or dividend rights, and are considered not to have any economic value.   

Details  of  employee  share  option  schemes  are  set  out  in  Note  9.  During  2020  no  share  options  were 
issued and none lapsed. No person has any special right of control over the Company’s share capital and 
all issued shares are fully paid. 

The appointment and replacement of directors of the Company is governed by its Articles of Association, 
the Companies Act 2006 and related legislation. The Articles themselves may be amended by special 
resolution of the shareholders. 

Donations 

No charitable or political donations were made during the year (2019: £Nil). 

Share issues 

Details of shares issued during the year are set out in Note 9. 

Going concern 

The directors have concluded, having regard to the most recent expenditure projections available, that the 
Company has in place sufficient funding to enable them to continue as a  going concern and meet their 
liabilities to third parties as they fall due for the foreseeable future. The Company has generated sufficient 
funds in May 2021 in order to meet its committed liabilities as they fall due for the foreseeable future.  

Post balance sheet events 

The Company completed the acquisition of Cizzle Biotechnology Limited on 14 May 2021 as noted in the 
Chairman’s  Statement  and  note  23  to  these  financial  statements.  The  directors  continue  to  assess  the 
impact of the COVID-19 situation and how this might impact the Company.  

Disclosure of information to auditor 

The directors who held office at the date of approval of this Directors’ Report confirm that, so far as they 
are aware, there is no relevant audit information of which the Company’s auditor is unaware; and each 
Director has taken all steps that he ought to have taken as a Director to make himself aware of any relevant 
audit information and to establish that the Company’s auditor is aware of that information. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

7 

Directors’ Report for the year ended 31 December 2020 (continued) 

Auditor 

The existing auditors of the Company are PKF Littlejohn LLP and a resolution for their re-appointment will 
be put to the General Meeting that will be held during June 2021. 

General Meeting 

The Annual Report is made available to shareholders at least 21 clear days’ notice before the General Meeting 
(“GM”)  along  with  the  notice  of  the  GM.  Shareholders  are  given  the  opportunity  to  vote  on  each  separate 
resolution proposed at the GM. The Company counts all proxy votes and will indicate the level of proxies lodged 
for each resolution, after it has first been dealt with by a show of hands, which will be subject to the removal of 
government restrictions arising from the Covid-19 pandemic. 

Directors’ Responsibilities Statement 

The  directors  are  responsible  for  preparing  the  strategic  report,  the  directors’  report  and  the  financial 
statements in accordance with applicable law and regulations.  

Company law requires the Directors to prepare financial statements for each financial year.  Under that 
law  the  Directors  have  elected  to  prepare  the  financial  statements  in  accordance  with  international 
accounting standards in conformity with the requirements of the Companies Act 2006.  Under company 
law the Directors must not approve the financial statements unless they are satisfied that they give a true 
and fair view of the state of affairs of the Company and of the profit or loss for that period.   

In preparing these financial statements, the Directors are required to: 

select suitable accounting policies and then apply them consistently; 

• 
•  make judgements and accounting estimates that are reasonable and prudent; 
• 

state whether they have been prepared in accordance with international accounting standards in 
conformity with the requirements of the Companies Act 2006, subject to any material departures 
disclosed and explained in the financial statements; and 

•  prepare the financial statements on the going concern basis unless it is inappropriate to presume 

that the Company will continue in business. 

The Directors are responsible for keeping adequate accounting records that are sufficient to show and 
explain  the  Company’s  transactions  and  disclose  with  reasonable  accuracy  at  any  time  the  financial 
position  of  the  Company  and  enable  them  to  ensure  that  the  financial  statements  comply  with  the 
requirements of the Companies Act 2006.  They are also responsible for safeguarding the assets of the 
Company  and  hence  for  taking  reasonable  steps  for  the  prevention  and  detection  of  fraud  and  other 
irregularities. 

Website publication 

The Directors are responsible for the maintenance and integrity of the corporate and financial information 
included on the Company’s website.  Legislation in the United Kingdom governing the preparation and 
dissemination of the financial statements may differ from legislation in other jurisdictions. 

Approved by the Board of Directors and signed by order of the Board 

Nigel Lee 
Director 
20 May 2021 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

8 

Corporate Governance Statement 

The  Directors  recognise  the  importance  of  sound  corporate  governance.    As  a  company  whose  shares 
were previously traded on AIM and are now in 2021 on the main market of the London Stock Exchange, 
the board has concluded that it will adopt the Quoted Companies Alliance’s Corporate Governance Code 
(“the QCA Code”).  In addition, the directors have adopted a code of conduct for dealings in the shares of 
the  Company  by  directors  and  employees  and  are  committed  to  maintaining  the  highest  standards  of 
corporate governance.  Throughout 2020 Allan Syms, a non-executive director and the Chairman of the 
Company, has taken on responsibility for these standards.  

The  corporate  governance  arrangements  that  the  board  has  adopted  are  designed  to  ensure  that  the 
Company delivers long term value to its shareholders and that shareholders have the opportunity to express 
their views and expectations for the Company in a manner that encourages open dialogue with the board.  
The board recognises that their decisions regarding strategy and risk will impact the corporate culture of 
the Company as a whole and that this will impact the performance of the Company.  The board is very 
aware that the tone and culture set by the board will greatly impact all aspects of the Company as a whole 
and the way that employees behave. 

During  2020  the  directors  have  been  working  hard  through  respectful  dialogue  with  their  professional 
advisers to seek a new investment opportunity for the Company. Therefore, the importance of sound ethical 
values  and  behaviours  is  crucial  to  the  ability  of  the  Company  to  successfully  achieve  its  corporate 
objectives.  

The  board  places  great  importance  on  this  aspect  of  corporate  life  and  seeks  to  ensure  that  this  flows 
through all that the Company does.   

At 31 December 2020, as a Cash Shell, the board consisted of three non-executive directors and does not 
have  a  CEO.  During  May  2021  the  board  composition  changed  with  Allan  Syms  becoming  Executive 
Chairman,  the  appointment  of  Nigel  Lee  as  Finance  Director  and  Professor  Dawn  Coverley  as  a  non-
executive director. Martin Lampshire has resigned and the board thank him for his support in concluding 
the  acquisition  of  Cizzle  Biotechnology  Limited.  The  board  continues  to  consider  whether  it  would  be 
appropriate to seek to appoint additional non-executive and/or executive directors but at this time believes 
that appropriate oversight of the Company is provided by the currently constituted board.  This view will 
continue to be reviewed by the board.  

Allan Syms 
Executive Chairman 

 
 
     
  
  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

9 

Corporate Governance Statement (continued) 

The QCA Code sets out 10 principles which should be applied.  These are listed below together with a short 
explanation of how the Company applies each of the principles. Where the Company does not fully apply 
each principle an explanation as to why has also been provided: 

Principle One - Business Model and Strategy 

The board had adopted a strategy for each business unit as outlined in the Business Review in the Strategic 
Report on page 3. Since April 2019 the focus of the directors has been to ensure that the Company has 
sufficient cash resources in order to seek a new investment opportunity. 

Principle Two - Understanding Shareholder Needs and Expectations 

The  board  is  committed  to  maintaining  good  communication  and  having  constructive  dialogue  with  its 
shareholders. Institutional shareholders and analysts have the opportunity to discuss issues and provide 
feedback  at  meetings  with  the  Company.  In  addition,  all  shareholders  are  encouraged  to  attend  the 
Company’s Annual General Meeting. Investors also have access to current information on the Company 
though its website, www.bouldopportunities.com and via Allan Syms, Executive Chairman who is available 
to answer investor relations enquiries through IFC Advisory Limited (bould@investor-focus.co.uk). 

Principle Three - Stakeholder Responsibilities 

The  board  recognises  that  the  long-term  success  of  the  Company  is  reliant  upon  the  efforts  of  the 
employees of the Company and its contractors, suppliers and regulators.  The board has put in place a 
range  of  processes  and  systems  to  ensure  that  there  is  close  board  oversight  and  contact  with  its  key 
resources  and  relationships.    For  example,  all  employees  of  the  Company  participate  in  a  structured 
Company-wide  annual  assessment  process  which  is  designed  to  ensure  that  there  is  an  open  and 
confidential dialogue with each person in the Company to help ensure successful two-way communication 
with  agreement  on  goals,  targets  and  aspirations  of  the  employee  and  the  Company.    These  feedback 
processes  help  to  ensure  that  the  Company  can  respond  to  new  issues  and  opportunities  that  arise  to 
further the success of employees and the Company.   

Principle Four - Risk Management 

In addition to its other roles and responsibilities the Audit and Compliance Committee is responsible to the 
board for ensuring that procedures are in place, and are being effectively implemented to identify, evaluate 
and manage the significant risks faced by the Company.  The risk assessment matrix below sets out those 
risks, and identifies their ownership and the controls that are in place.  This matrix is updated as changes 
arise in the nature of risks or the controls that are implemented to mitigate them.  The Audit Committee 
reviews the risk matrix and the effectiveness of scenario testing on a regular basis. The following principal 
risks, and controls to mitigate them, have been identified during 2020: 

Activity 
Management  Recruitment and 

Risk 

retention of key staff 

Impact 
Reduction  in  operating 
capability 

Regulatory 
adherence 
Strategic 

rules  or 

Breach  of 
product requirements 
Damage to reputation 

Financial 

Inadequate disaster 
recovery procedures 
Liquidity, market and 
credit risk. 

. 

Censure  or  withdrawal 
of authorisation 
Inability  to  secure  new 
customers. 
Loss of key operational 
and financial data. 
Inability  to  continue  as 
going concern. 

Control(s) 
Stimulating  and  safe  working 
environment. Balancing salary with 
longer term incentive plans. 
Strong product compliance regime. 

communications  with 

Effective 
shareholders. 
Secure off-site storage of data. 

Robust financial controls and 
procedures throughout the 
Company. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

10 

Principle Four - Risk Management (continued) 

Since  the  Company  became  a  Cash  Shell  on  5  April  2019  the  risks  relating  to  Regulatory  adherence, 
Strategic and Financial are still relevant. 

In  2020  the  directors  had  already  established  procedures,  as  represented  by  this  and  previous  years’ 
statements, for the purpose of providing a system of internal control.  In addition, there were a range of 
Company policies that were reviewed at least annually by the board and a programme of training and then 
confirmation of understanding that all employees of the Company were required to undertake each year.  
These Company policies covered matters such as share dealing, insider legislation and expenses. In 2020 
the Board took the view that an internal audit function was not considered necessary or practical due to the 
size of the Company and the close day to day control exercised by the then executive directors.  The board 
continues to monitor the need for new systems of internal control and an internal audit function. 

The  annual  review  of  internal  control  and  financial  reporting  procedures  did  not  highlight  any  issues 
warranting  the  introduction  of  an  internal  audit  function.  It  was  concluded,  given  the  current  size  and 
transparency of the operations of the Company, that an internal audit function was not required. 

Principle Five - A Well-Functioning Board of Directors 

During 2020 the board of directors remain unchanged with Allan Syms as the non-executive Chairman, 
Martin Lampshire and John Treacy as non-executive directors. The time commitment formally required by 
the Company is an overriding principal that each director will devote as much time as is required to carry 
out the roles and responsibilities that the director has agreed to take on. The current non-executive directors 
of the Company are all part-time.  Biographical details of the current directors are set out within Principle 
Six below.  

Executive and non-executive directors are subject to re-election intervals as prescribed in the Company’s 
Articles  of  Association.  At  each  Annual  General  Meeting  one-third  of  the  Directors,  who  are  subject  to 
retirement by rotation shall retire from office. They can then offer themselves for re-election. The letters of 
appointment of all directors are available for inspection at the Company’s registered office during normal 
business hours.  

Non-Executive  Directors  and  the  Chairman  receive  payments  under  appointment  letters  which  are 
terminable by either one or three months’ notice by either party. 

The  Non-Executive  Chairman  (Executive  Chairman  in  May  2021)  receives  a  fee  for  his  services  as  a 
director which is approved by the board, being mindful of the time commitment and responsibilities of their 
roles  and  of  current  market  rates  for  comparable  organisations  and  appointments.  The  Non-Executive 
Chairman is also reimbursed for travelling and other incidental expenses incurred on Group business. 

The board encourages the ownership of shares in the Company by Executive and Non-Executive Directors 
alike and in normal circumstances does not expect Directors to undertake dealings of a short-term nature. 
The Board considers ownership of Company shares by Non-Executive Directors as a positive alignment of 
their interest with shareholders. The board will periodically review the shareholdings of the Non-Executive 
Directors and will seek guidance from its advisors if, at any time, it is concerned that the shareholding of 
any  Non-Executive  Director  may,  or  could  appear  to,  conflict  with  their  duties  as  an  independent  Non-
Executive Director of the Company or their independence itself. Directors’ emoluments, including Directors’ 
interest in share options over the Company’s share capital, are set out in Note 9. 

The board meets on average at least six times throughout the year. It has established an Audit Committee 
and  a  Remuneration  Committee,  particulars  of  which  appear  hereafter.    The  board  agreed  that 
appointments  to  the  board  are  made  by  the  board  as  a  whole  and  so  has  not  created  a  Nominations 
Committee. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

11 

Principle Five - A Well-Functioning Board of Directors (continued) 

Attendance at Board and Committee Meetings  
The board retains full control of the Company.  The full board meets at least every other month and on any 
other  occasions  it  considers  necessary.    During  2020  there  were  fourteen  board  meetings,  one 
Remuneration Committee meeting and one Audit Committee meeting. All meetings were fully attended by 
their constituent directors. 

Principle Six - Appropriate Skills and Experience of the Directors 

Directors who served during 2020: 
During  2020  the  board  consisted  of  three  Non-Executive  Directors.  In  addition,  the  Company  uses  the 
services of CFO Solutions Limited for ad hoc financial advisory services and also to act as the Company 
Secretary.   

The directors of the Company during the year were are as follows: 

Allan Syms, Non-Executive Chairman (Appointed 21 May 2019) 
Allan is an experienced public and private company director, with a background in Corporate Finance, IPOs 
and managing strategic change. Allan holds a PhD in cancer research and began his corporate career at 
GE  Healthcare  (formerly  Amersham  International  PLC).   He  has  spent  the  past  30  years  creating  and 
through  private  and  public  fundraising, building  emerging  technology  businesses.  He  was  previously  an 
adviser to the Department of International Trade.  

Martin Lampshire, Non-executive Director (Appointed 14 January 2019, resigned 13 May 2021) 
Martin started his career in Lloyds Bank’s Commercial Services division in 1989 after completing the ACIB 
qualification. 
He  has  over  twenty  years’  experience  in  Corporate  Broking,  working  for  a  number  of  city-based  firms 
including  Teather  &  Greenwood,  Charles  Stanley,  Hichens  Harrison  Stockbrokers  and  Daniel  Stewart 
Stockbrokers. 
He  has  assisted  many  companies  in  a  variety  of  equity  raises  including  IPO’s,  secondary  fundraisings, 
vendor  and  private  placings  across  a  variety  of  sectors.  He  has  also  worked  in  a  number  of  overseas 
financial centres including Hong Kong, Singapore, Kuala Lumpur and Dubai. Martin joined the board as a 
Non-executive director on 14 January 2019. 

John Treacy, Non-executive Director (Appointed 29 January 2019) 
John  is  a  London-based  experienced  small  cap  financier  who  specialises  in  working  with  growing 
companies.  He  qualified  as  a  solicitor  in  the  London  office  of  a  major  international  law  firm  where  he 
specialised  in  Capital  Markets  and  Mergers  &  Acquisitions.  From  there  he  moved  to  practice  corporate 
finance  in  the  advisory  teams  of  several  prominent  UK  brokerages  where  he  acted  as  an  adviser  to  a 
number of AIM companies and advised on numerous IPOs, acquisitions, debt restructurings and placings. 

Principle Seven - Evaluation of Board Performance 

Internal evaluation of the board, the Committee and individual directors is seen as an important next step 
in the development of the board and one that will be addressed once the new strategic direction of the 
Company has been determined. The aim is that this will be undertaken on an annual basis in the form of 
peer appraisal, questionnaires and discussions to determine the effectiveness and performance in various 
areas as well as the directors’ continued independence. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

12 

Principle Eight - Corporate Culture 

During 2020, the board recognised that their decisions regarding strategy and risk will impact the corporate 
culture of the Company as a whole and that this will impact the performance of the Company.  The board 
is very aware that the tone and culture set by the board will greatly impact all aspects of the Company as a 
whole and the way that employees behave.  A large part of the Company’s activities was centred upon 
addressing market needs. Therefore, the importance of sound ethical values and behaviours is crucial to 
the  ability  of  the  Company  to  successfully  achieve  its  corporate  objectives.    The  board  places  great 
importance on this aspect of corporate life and seeks to ensure that this flows through all that the Company 
does.  The board assessment of the culture within the Company at the present time is one where there is 
respect for all individuals and there is open dialogue within the Company. 

Principle Nine - Maintenance of Governance Structures and Processes 

Ultimate authority for all aspects of the Company’s activities rests with the board. The board has adopted 
two  statements  during  2020;  the  first  sets  out  matters  which  are  reserved  to  the  Board  and  the  second 
establishes  the  division  of  responsibilities  between  the  Chairman  and  the  other  non-executive  directors. 
The Chairman is responsible for the effectiveness of the board.  

Audit Committee  
During  2020  the  Audit  Committee  comprised  Allan  Syms  (Chairman)  and  is  also  attended  by  a 
representative of CFO Solutions Limited. It meets as required and specifically to review the Interim Report 
and  Annual  Report,  and  to  consider  the  suitability  and  monitor  the  effectiveness  of  internal  control 
processes. There was one meeting of the Audit Committee during 2020. The Audit Committee also reviews 
the findings of the external auditor and reviews accounting policies and material accounting judgements. 

The  independence  and  effectiveness  of  the  external  auditor  is  reviewed  annually.  The  possibility  of 
undertaking an audit tender process is considered on a regular basis. The Audit Committee meets at least 
once a year with the auditor to discuss their independence and objectivity, the Annual Report, any audit 
issues arising, internal control processes, appointment and fee levels and any other appropriate matters. 
As well as providing audit related services, the auditor also provides taxation and other advice. The fees in 
respect of audit and tax services are set out in Note 13. Fees for non-audit services paid to the auditor are 
not deemed to be of such significance to them as to impair their independence and therefore the Audit 
Committee considers that the objectivity and independence of the auditor is safeguarded. 

Remuneration Committee 
During  2020  the  Remuneration  Committee  comprised  of  Allan  Syms  as  Chairman.  The  purpose  of  the 
Remuneration Committee is to ensure that the Executive Directors and other employees are fairly rewarded 
for their individual contribution to the overall performance of the Company. The Committee considers and 
recommends  to  the  board  the  remuneration  of  the  Executive  Directors  and  is  kept  informed  of  the 
remuneration  packages  of  senior  staff  and  invited  to  comment  on  these.  There  was  one  Remuneration 
Committee  meeting  during  2020.  The  board  retains  responsibility  for  overall  remuneration  policy.  The 
Remuneration Committee recommends to the board the remuneration packages by reference to individual 
performance  and  uses  the  knowledge  and  experience  of  the  Committee  members,  published  surveys 
relating  to  similar  companies  and  market  changes  generally.  The  Remuneration  Committee  has 
responsibility for recommending any long-term incentive schemes. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

13 

Principle Nine - Maintenance of Governance Structures and Processes (continued) 

Remuneration Committee (continued) 

The  board  determines  whether  or  not  Executive  Directors  are  permitted  to  serve  in  roles  with  other 
companies. Such permission would only be granted on a strictly limited basis, where there are no conflicts 
of interest or competing activities and providing there is not an adverse impact on the commitments required 
to the Company. Earnings from such roles would be required to be disclosed to the Chairman.  

During 2020, there were two main elements of the remuneration package for Non-Executive Directors and 
former employees: 
1. 
Basic  salaries  and  benefits  in  kind:  Basic  salaries  are  recommended  to  the  board  by  the 
Remuneration Committee, taking into account the performance of the individual and the rates for similar 
positions  in  comparable  companies.  Certain  benefits  in  kind  are  available  to  certain  senior  staff  and 
Executive Directors. 
2. 
Share  options:  The  Company  operates  approved  and  unapproved  share  option  schemes  for 
Executive  Directors  and  other  employees  to  motivate  those  individuals  through  equity  participation. 
Exercise of share options under the schemes is subject to specified exercise periods and compliance with 
the  AIM  Rules.  The  schemes  are  overseen  by  the  Remuneration  Committee  which  recommends  to  the 
Board  all  grants  of  share  options  based  on  the  Remuneration  Committee’s  assessment  of  personal 
performance and specifying the terms under which eligible individuals may be invited to participate. It is 
intended that the performance related elements of remuneration form a significant proportion of the total 
remuneration  package  of  Executive  Directors  and  be  designed  to  align  their  interests  with  those  of 
shareholders. In this development phase of the Company the Remuneration Committee currently considers 
that the best alignment of these interests is through the continued use of incentives for performance through 
the award of share options. 

Non-executive Directors 
The board has adopted guidelines for the appointment of non-executive directors which have been in place 
and  which  have  been  observed  throughout  the  year.  These  provide  for  the  orderly  and  constructive 
succession and rotation of the Chairman and non-executive directors insofar as both the Chairman and 
Non-Executive Directors will be appointed for an initial term of three years and may, at the Board’s discretion 
believing it to be in the best interests of the Company, be appointed for subsequent terms.  The Chairman 
may serve as a non-executive director before commencing a first term as Chairman. In accordance with the 
Companies  Act  2006,  the  board  complies  with:  a  duty  to  act  within  their  powers;  a  duty  to  promote  the 
success of the Company; a duty to exercise independent judgement; a duty to exercise reasonable care, 
skill and diligence; a duty to avoid conflicts of interest; a duty not to accept benefits from third parties and a 
duty to declare any interest in a proposed transaction or arrangement. 

Principle Ten - Shareholder Communication 

The  board  is  committed  to  maintaining  good  communication  and  having  constructive  dialogue  with  its 
shareholders. Institutional shareholders and analysts have the opportunity to discuss issues and provide 
feedback  at  meetings  with  the  Company.  In  addition,  all  shareholders  are  encouraged  to  attend  the 
Company’s Annual General Meeting. Investors also have access to current information on the Company 
though  its  website,  www.bouldopportunities.com  and  via  Allan  Syms,  non-executive  Chairman  who  is 
available  to  answer  investor  relations  enquiries  through  IFC  Advisory  Limited  (bould@investor-
focus.co.uk). 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

14 

INDEPENDENT AUDITOR’S REPORT TO THE MEMBERS OF BOULD OPPORTUNITIES PLC 
(TO BE RENAMED CIZZLE BIOTECHNOLOGY HOLDINGS PLC) 

Opinion  

We have audited the financial statements of Bould Opportunities PLC (the ‘company’) for the year ended 
31 December 2020 which comprise the Statement of Comprehensive Income, the Statement of Financial 
Position,  the  Statement  of  Changes  in  Equity,  the  Statement  of  Cash  Flows  and  notes  to  the  financial 
statements,  including  significant  accounting  policies.  The  financial  reporting  framework  that  has  been 
applied in their preparation is applicable law and international accounting standards in conformity with the 
Companies Act 2006.  

In our opinion, the financial statements:  

•  give a true and fair view of the state of the company’s affairs as at 31 December 2020 and of its 

loss for the year then ended;  

•  has been properly prepared in accordance with international accounting standards in conformity 

with the requirements of the Companies Act 2006; and 

•  have been prepared in accordance with the requirements of the Companies Act 2006.  

Basis for opinion  

We  conducted  our  audit  in  accordance  with  International  Standards  on  Auditing  (UK)  (ISAs  (UK))  and 
applicable  law.  Our  responsibilities  under  those  standards  are  further  described  in  the  Auditor’s 
responsibilities for the audit of the financial statements section of our report. We are independent of the 
company  in  accordance  with  the  ethical  requirements  that  are  relevant  to  our  audit  of  the  financial 
statements in the UK, including the FRC’s Ethical Standard as applied to listed public interest entities, and 
we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that 
the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.  

Conclusions relating to going concern  

In auditing the financial statements, we have concluded that the director's use of the going concern basis 
of accounting in the preparation of the financial statements is appropriate. Our evaluation of the directors’ 
assessment of the company’s ability to continue to adopt the going concern basis of accounting included a 
review  of  the  directors’  statement  in  note  2.2  to  the  financial  statements  and  review  of  the  company’s 
budgets for the period of twelve months from the date of approval of the financial statements, including 
checking the mathematical accuracy of the budgets and discussion of significant assumptions used by the 
management. 

We  have  also  reviewed  the  latest  available  post  year  end  management  accounts,  bank  statements, 
regulatory announcements, board minutes and assessed any external industry wide factors which might 
affect the company.   

Based on the work we have performed, we have not identified any material uncertainties relating to events 
or conditions that, individually or collectively, may cast significant doubt on the company's ability to continue 
as a going concern for a period of at least twelve months from when the financial statements are authorised 
for issue. 

Our responsibilities and the responsibilities of the directors with respect to going concern are described in 
the relevant sections of this report. 

Our application of materiality  

The scope of our audit was influenced by our application of materiality. The quantitative and qualitative 
thresholds for materiality determine the scope of our audit and the nature, timing and extent of our audit 
procedures. The materiality applied to the financial statements was £18,300 based on 6% of the loss before 
tax.  We  believe  the  loss  before  tax  to  be  the  main  driver  of  a  non-trading  company  working  towards 
completion of an acquisition. Performance materiality was £14,600.   

We agreed with those charged with governance that we would report to them all audit differences identified 
during the course of our audit in excess of £900. We also agreed to report any other audit misstatements 
below that threshold that we believe warranted reporting on qualitative grounds. There were no misstatements 
identified during the course of our audit that were individually, or in aggregate, considered to be material. 

 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

15 

Our approach to the audit 

In designing our audit approach, we determined materiality and assessed the risk of material misstatement 
in the financial statements. In particular, we looked at areas involving significant accounting estimates and 
judgement by the directors and considered future events that are inherently uncertain. We also addressed 
the  risk  of  management  override  of  internal  controls,  including  among  other  matters  consideration  of 
whether there was evidence of bias that represented a risk of material misstatement due to fraud.  

Key audit matters  

Key audit matters are those matters that, in our professional judgment, were of most significance in our 
audit of the financial statements of the current period and include the most significant assessed risks of 
material misstatement (whether or not due to fraud) we identified, including those which had the greatest 
effect on: the overall audit strategy, the allocation of resources in the audit; and directing the efforts of the 
engagement team. These matters were addressed in the context of our audit of the financial statements as 
a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters.  

Key Audit Matter 

How our scope addressed this matter 

Going concern (refer to Note 2.2) 

As at 31 December 2020, the company had cash 
and cash equivalents of £84,000, was not trading 
and  was  working  towards  completion  of  an 
acquisition. The company shares ceased trading 
on  AIM  during  2019.  Additional  funds  were 
required to be raised to ensure the company has 
sufficient working capital over the going concern 
period. 

We have considered going concern to be a key 
audit matter due to the losses incurred during the 
year, in conjunction with the amount of cash and 
cash equivalents held at year-end. 

We  performed  a  review  of  the  cash  flow 
projections over the going concern period and 
significant 
for 
the 
assessed 
current 
based 
reasonableness 
requirements 
the 
in  2020  and 
acquisition of Cizzle Biotechnology Limited.  

following 

inputs 

upon 

We  tested  the  £2.2  million  equity  placing 
completed subsequent to the year-end to bank 
statements and the cash at bank position as at 
the  date  of  approval  of 
financial 
statements. 

the 

We  found  the  key  assumptions  made  by  the 
Directors  in  respect  of  going  concern  to  be 
reasonable and the disclosures in the financial 
statements 
line  with  applicable 
in 
accounting standards. 

to  be 

Other information  

The  other  information  comprises  the  information  included  in  the  annual  report,  other  than  the  financial 
statements  and  our  auditor’s  report  thereon.  The  directors  are  responsible  for  the  other  information 
contained  within  the  annual  report.  Our  opinion  on  the  financial  statements  does  not  cover  the  other 
information and, except to the extent otherwise explicitly stated in our report, we do not express any form 
of  assurance  conclusion  thereon.  Our  responsibility  is  to  read  the  other  information  and,  in  doing  so, 
consider  whether  the  other  information  is  materially  inconsistent  with  the  financial  statements  or  our 
knowledge obtained in the course of the audit, or otherwise appears to be materially misstated. If we identify 
such material inconsistencies or apparent material misstatements, we are required to determine whether 
this gives rise to a material misstatement in the financial statements themselves. If, based on the work we 
have performed, we conclude that there is a material misstatement of this other information, we are required 
to report that fact.  

We have nothing to report in this regard.  

Opinions on other matters prescribed by the Companies Act 2006  

In our opinion, based on the work undertaken in the course of the audit:  

• 

• 

the information given in the strategic report and the directors’ report for the financial year for which 
the financial statements are prepared is consistent with the financial statements; and  
the  strategic  report  and  the  directors’  report  have  been  prepared  in  accordance  with  applicable 
legal requirements.  

 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

16 

Matters on which we are required to report by exception 

In the light of the knowledge and understanding of the company and its environment obtained in the course 
of the audit, we have not identified material misstatements in the strategic report or the directors’ report.  

We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 
requires us to report to you if, in our opinion:  

•  adequate accounting records have not been kept, or returns adequate for our audit have not been 

• 

received from branches not visited by us; or  
the financial statements and the part of the directors’ remuneration report to be audited are not in 
agreement with the accounting records and returns; or 
• 
certain disclosures of directors’ remuneration specified by law are not made; or  
•  we have not received all the information and explanations we require for our audit.  

Responsibilities of directors  

As  explained  more  fully  in  the  directors’  responsibilities  statement,  the  directors  are  responsible  for  the 
preparation of the financial statements and for being satisfied that they give a true and fair view, and for 
such  internal  control  as  the  directors  determine  is  necessary  to  enable  the  preparation  of  financial 
statements that are free from material misstatement, whether due to fraud or error.  

In preparing the financial statements, the directors are responsible for assessing the company’s ability to 
continue  as  a  going  concern,  disclosing,  as  applicable,  matters  related  to  going  concern  and  using  the 
going concern basis of accounting unless the directors either intend to liquidate the company or to cease 
operations, or have no realistic alternative but to do so.  

Auditor’s responsibilities for the audit of the financial statements  

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are 
free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes 
our  opinion.  Reasonable  assurance  is  a  high  level  of  assurance  but  is  not  a  guarantee  that  an  audit 
conducted  in  accordance  with  ISAs  (UK)  will  always  detect  a  material  misstatement  when  it  exists. 
Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, 
they could reasonably be expected to influence the economic decisions of users taken on the basis of these 
financial statements.  

Irregularities,  including  fraud,  are  instances  of  non-compliance  with  laws  and  regulations.  We  design 
procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of 
irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, 
including fraud is detailed below: 

•  We obtained an understanding of the company and the sector in which they operate to identify laws 
and  regulations  that  could  reasonably  be  expected  to  have  a  direct  effect  on  the  financial 
statements. We obtained our understanding in this regard through discussions with management 
and application of cumulative audit knowledge.  

•  We determined the principal laws and regulations relevant to the company in this regard to be those 

arising from the Companies Act 2006. 

•  We designed our audit procedures to ensure that the audit team considered whether there were 
any  indications  of  non-compliance  by  the  company  with  those  laws  and  regulations.  This  is 
evidenced  by  our  discussion  of  laws  and  regulations  with  management,  reviewing  minutes  of 
meetings of those charged with governance and review of regulatory news.  

•  We also identified the risks of material misstatement of the financial statements due to fraud. Aside 
from  the  non-rebuttable  presumption  of  a  risk  of  fraud  arising  from  management  override  of 
controls, we did not identify any significant fraud risks.  

•  As in all of our audits, we addressed the risk of fraud arising from management override of controls 
by performing audit procedures which included, but were not limited to: the testing of journals and 
evaluating  the  business  rationale  of  any  significant  transactions  that  are  unusual  or  outside  the 
normal course of business or where the business rationale is not clear.  

 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

17 

Because of the inherent limitations of an audit, there is a risk that we will not detect all irregularities, including 
those  leading  to  a  material  misstatement  in  the  financial  statements  or  non-compliance  with  regulation.  
This  risk  increases  the  more  that  compliance  with  a  law  or  regulation  is  removed  from  the  events  and 
transactions reflected in the financial statements, as we will be less likely to become aware of instances of 
non-compliance. The risk is also greater regarding irregularities occurring due to fraud rather than error, as 
fraud involves intentional concealment, forgery, collusion, omission or misrepresentation. 

A further description of our responsibilities for the audit of the financial statements is located on the Financial 
Reporting Council’s website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our 
auditor’s report.  

Other matters which we are required to address  

Our total uninterrupted period of engagement is 3 years, covering the periods ending 31 December 2018 
to December 2020. 

The non-audit services prohibited by the FRC’s Ethical Standard were not provided to the company and we 
remain independent of the company in conducting our audit. 

Our audit opinion is consistent with the additional report to.  

Use of our report 

This report is made solely to the company’s members, as a body, in accordance with Chapter 3 of Part 16 
of the Companies Act 2006.  Our audit work has been undertaken so that we might state to the company’s 
members those matters we are required to state to them in an auditor’s report and for no other purpose.  
To the fullest extent permitted by law, we do not accept or assume responsibility to anyone, other than the 
company and the company's members as a body, for our audit work, for this report, or for the opinions we 
have formed. 

David Thompson (Senior Statutory Auditor)  
For and on behalf of PKF Littlejohn LLP 
Statutory Auditor 

15 Westferry Circus 
Canary Wharf 
London E14 4HD 

20 May 2021 

 
 
 
                                                  
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

18

Statement of Comprehensive Income 
for the year ended 31 December 2020 

Notes 

                  2020 
£’000 

Continuing Operations 
Revenue 
Cost of sales 
Gross profit  

Administrative expenses  
Loss on disposal of subsidiary undertakings 
Proposed Transaction expenses 
Total administrative expenses 
Operating loss and loss before income tax 

Income tax  
Loss and total comprehensive income for the year 
attributable to the equity shareholders of the parent 

Earnings per ordinary share (pence) attributable to 
the equity shareholders: 
Continued operations basic and diluted 
Earnings per ordinary share (pence) attributable to 
the equity shareholders of the parent 

5 
5 
5 

16 

17 

17 

- 
- 
- 

(229) 
- 
(77) 
(306) 
(306) 

- 
(306) 

(0.0) 

(0.0) 

2019 
£’000 

- 
- 
- 

(356) 
(201) 
(275) 
(832) 
(832) 

-  

(832) 

(0.0) 

(0.0) 

The notes on pages 22 to 35 are an integral part of these financial statements. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

19

Registered number: 06133765 (England and Wales) 

Statement of Financial Position  
As at 31 December 2020 

Non-current assets 
Investments 

Current assets 
Trade and other receivables 
Cash and cash equivalents 

Total assets 

Equity 
Capital and reserves attributable to equity holders 
of the company 
Ordinary shares 
Share premium 
Share capital reduction reserve 
Accumulated losses 
Total equity 

Liabilities 
Current liabilities 
Trade and other payables 
Total liabilities 
Total equity and liabilities 

Notes 

2020 
£’000 

2019 
£’000 

6 

7 
8 

9 

22 

11 

- 
- 

6 
84 

90 
90 

3,470 
8,852 
10,081 
(22,371) 
32 

58 
58 
90 

- 
- 

31 
378 

409 
409 

3,470 
8,852 
10,081 
(22,065) 
338 

71 
71 
409 

The notes on pages 22 to 35 are an integral part of these financial statements. 

The financial statements were approved and authorised for issue by the board on 20 May 2021 
and were signed on its behalf by: 

Nigel Lee 
Director 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

20 

Statement of Cash Flows 
for the year ended 31 December 2020 

Cash flows from operating activities 

Loss before tax 

Change in trade and other receivables 

Change in trade and other payables 

Net cash used in operating activities 

Cash flows from financing activities 
Proceeds from the issue of ordinary shares (net of issue 
costs) 

Net cash generated from financing activities 

Net (decrease)/increase in cash and cash equivalents 
Cash and cash equivalents at the start of the year 

Cash and cash equivalents at the end of the year 

Notes 

7 

11 

9 

8 

8 

2020 

£'000 

(306) 

25 

(13) 

(294) 

- 

- 

(294) 
378 

84 

2019 

£'000 

(832) 

48 

(46) 

(830) 

1,206 

1,206 

376 
2 

378 

The notes on pages 22 to 35 are an integral part of these financial statements. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

21 

Statement of Changes in Equity  
for the year ended 31 December 2020 

Ordinary 
share 
capital 
£’000 
2,355 

Share  
premium 
£’000 
8,806 

Share 
capital 
reduction 
reserve 
£’000 
10,081 

Share 
option 
reserve 
£’000 
- 

Retained 
losses 
£’000 
(21,278) 

Total 
£’000 
(36) 

Balance at 1 January 2019 

Contributions by and 
distributions to owners 

Issue of new shares (net of issue 
costs) 

1,115 

91 

Issue of warrants (Note 9) 

- 

(45) 

Loss and total comprehensive 
income for the year 
Balance at 31 December 2019 

1,115 

- 

46 

- 

3,470 

8,852 

10,081 

- 

- 

- 

- 

Loss and total comprehensive 
income for the year 
Balance at 31 December 2020 

- 

- 

- 

3,470 

8,852 

10,081 

The notes on pages 22 to 35 are an integral part of these financial statements. 

- 

- 

- 

- 

- 

- 

- 

- 

1,206 

45 

45 

- 

1,206 

(832) 

(832) 

(22,065) 

338 

(306) 

(306) 

(22,371) 

32 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

22 

Notes to the financial statements for the year ended 31 December 2020 

1  General information 

On 8 April 2020 it was announced that, as neither a Reverse Takeover nor re-admission to trading as an 
investing company under the AIM Rules was achieved with in the required timescale, the admission to trading 
of the Company’s shares on AIM was cancelled. It was noted that it had been working for some time on 
completing the acquisition of an identified target in the biotechnology sector. On 14 May 2021 the Company 
completed the acquisition of Cizzle Biotechnology Limited and changed its name to Cizzle Biotechnology 
Holdings PLC.  

The directors consider there to be no ultimate controlling shareholder of the Company. 

The address of the registered office changed in May 2021 to 6th Floor, 60 Gracechurch Street, London, EC3V 
OHR and the registered number of the Company is 06133765.   

2 

Summary of significant accounting policies 

The principal accounting policies applied in the preparation of these financial statements are set out below. 
These policies have been consistently applied to all the years presented, unless otherwise stated. 

2.1  Basis of preparation 

The  financial  statements  of  Cizzle  Biotechnology  Holdings  PLC  have  been  prepared  in  accordance  with 
international accounting standards in conformity with the requirements of the Companies Act 2006 and in 
accordance with the requirements of the Companies Act 2006 and on a historical cost basis. 

The  preparation  of  financial  statements  requires  the  use  of  certain  critical  accounting  estimates.  It  also 
requires  management  to  exercise  its  judgement  in  the  process  of  applying  the  Company’s  accounting 
policies.  The areas involving a higher degree of judgement or complexity, or areas where assumptions and 
estimates are significant to the financial statements are disclosed in Note 4.  

(a)  New and amended standards adopted  

The Company has applied the following standards and amendments for the first time for its annual reporting 
period commencing 1 January 2020: 

•  Definition of Material – Amendments to IAS 1 and IAS 8; 
•  Definition of a Business – Amendments to IFRS 3;  
• 
•  Revised Conceptual Framework for Financial Reporting; 
•  Annual  Improvements  to  IFRS  Standards  2018-2020  Cycle;  andCOVID-19  related  rent 

Interest Rate Benchmark Reform – Amendments to IFRS 9, IAS 39 and IFRS 7; 

concessions – amendments to IFRS.. 

There  was  no  material  impact  on  the  financial  statements  on  the  adoption  of  these  new  and  amended 
standards. 

(b) 

New standards, amendments and interpretations not yet adopted 

There  are  no  IFRSs  or  IFRIC  interpretations  that  are  not  yet  effective  that  would  be  expected  to  have  a 
material impact on the Company. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

23 

Notes to the financial statements for the year ended 31 December 2020 

2 

Summary of significant accounting policies (continued) 

2.2  Going concern 

The Directors have adopted the going concern basis in preparing the financial statements for the year to 31 
December 2020. In reaching this conclusion, the Directors have considered for the Company, current trading 
and the current and projected funding position for the period until 31 March 2023. The Company has raised 
£2.2m  of  new  monies  (before  deal  costs)  through  the  issue  of  ordinary  shares  and  consider  that  it  has 
sufficient funds to meet its committed liabilities as they fall due for the foreseeable future.  

The assessment of the COVID-19 situation will need continued attention and will evolve over time. In our 
view,  COVID-19  is  considered  to  be  a  non-adjusting  post  statement  of  financial  position  event  and  no 
adjustment is made in the financial statements as a result. The rapid development and fluidity of the COVID-
19  virus  make  it  difficult  to  predict  the  ultimate  impact  at  this  stage.  Due  to  the  nature  of  the  Company’s 
activities, the impact has been minimal. Management will continue to assess the impact of COVID-19 on the 
Company, however, it is not possible to quantify the impact, if any, at this stage. 

Current funding 

The Company’s cash balance as at 31 December 2020 was £84,000 and there were no borrowing facilities 
at that date.  

Projected funding 

At the time of preparing these financial statements the Company has raised new funds as noted above, in 
the Chairman’s statement and note 23 to these financial statements. 

Conclusion 

After taking account of the Company’s current funding position, its cash flow projections and the risks and 
uncertainties  associated  with  these,  the  directors  have  a  reasonable  expectation  that  the  Company  has 
access  to  adequate  resources  to  continue  in  operational  existence  for  the  foreseeable  future.  For  these 
reasons  they  continue  to  prepare  the  financial  statements  on  a  going  concern  basis.  These  financial 
statements do not include any adjustments that would result from the going concern basis of preparation 
being inappropriate.  

2.3  Segmental reporting 

IFRS 8 requires that segmental information be disclosed on the basis of information reported to the chief 
operating  decision  maker.  The  Company  considers  that  the  role  of  chief  operating  decision  maker  is 
performed by the Company’s Board of Directors.  

On 19 June 2019 following the sale of its Halcyon and Light Engine business the Company was a holding 
company and had no other business activities/segments.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

24 

Notes to the financial statements for the year ended 31 December 2020 

2 

Summary of significant accounting policies (continued) 

2.4  Foreign currency translation 

The functional currency of the Company is Sterling which is also the presentational currency of the financial 
statements. Foreign currency assets and liabilities are converted into Sterling at the rates of exchange ruling 
at  the  end  of  the  financial  year.  Foreign  currency  transactions  are  translated  into  the  functional  currency 
using the exchange rates prevailing at the dates of the transactions. Foreign exchange gains and losses 
resulting from the settlement of such transactions and from the translation at year end exchange rates of 
monetary  assets  and  liabilities  denominated  in  foreign  currencies  are  recognised  in  the  statement  of 
comprehensive income. 

2.5 

Investments in subsidiaries 

Investments in subsidiaries are stated at cost less accumulated impairment. 

2.6   Cash and cash equivalents 

Cash and cash equivalents include cash in hand, deposits held at call with banks and other short-term highly 
liquid investments, with original maturities of three months or less.  

2.7  Share capital 

Ordinary shares are classified as equity. Incremental costs directly attributable to the issue of new shares or 
options are shown in equity as a deduction, net of tax, from the proceeds.  

2.8  Current and deferred income tax 

Current  income  tax  is  calculated  on  the  basis  of  the  tax  laws  enacted  or  substantively  enacted  at  the 
statement  of  financial  position  date  in  the  countries  where  the  Company’s  subsidiaries  and  associates 
operate and generate taxable income.  Management periodically evaluates positions taken in tax returns with 
respect to situations in which applicable tax regulation is subject to interpretation and establishes provisions 
where appropriate on the basis of amounts expected to be paid to the tax authorities.  

Deferred income tax is provided in full, using the liability method, on temporary differences arising between 
the  tax  bases  of  assets  and  liabilities  and  their  carrying  amounts  in  the  financial  statements.  However, 
deferred  income  tax  is  not  accounted  for  if  it  arises  from  initial  recognition  of  an  asset  or  liability  in  a 
transaction other than a business combination that at the time of the transaction affects neither accounting 
nor  taxable  profit  nor  loss.  Deferred  income  tax  is  determined  using  tax  rates  (and  laws)  that  have  been 
enacted or substantively enacted by the statement of financial position date and are expected to apply when 
the  related  deferred  income  tax  asset  is  realised  or  the  deferred  income  tax  liability  is  settled.    Deferred 
income tax assets are recognised to the extent that it is probable that future taxable profit will be available 
against which the temporary differences can be utilised. 

2.9       Share based payments 

The Company operates an equity-settled, share-based compensation plan.  The fair value of the employee 
services received in exchange for the grant of the options is recognised as an expense and credited to the 
share option reserve within equity.  The total amount to be expensed over the vesting period is determined 
by  reference  to  the  fair  value  of  the  options  granted,  excluding  the  impact  of  any  non-market  vesting 
conditions (for example, profitability and sales growth targets). Options that lapse before vesting are credited 
back to income. The proceeds received net of any directly attributable transaction costs are credited to share 
capital (nominal value) and, if applicable, share premium when the options are exercised. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

25 

Notes to the financial statements for the year ended 31 December 2020 

2 

Summary of significant accounting policies (continued) 

2.10 

Financial instruments 

i) Financial assets 

The Company classifies its financial assets in the following measurement categories: 

• 
• 

those to be measured subsequently at fair value through profit or loss; and 
those to be measured at amortised cost. 

The classification depends on the business model for managing the financial assets and the contracted terms 
of the cash flows. Financial assets are classified as at amortised cost only if both of the following criteria are 
met: 
• 
• 

the asset is held within a business model whose objective is to collect contracted cash flows; and 
the contractual terms give rise to cash flows that are solely payments of principal and interest. 

Financial assets, including trade and other receivables and cash and bank balances, are initially recognised 
at  transaction  price,  unless  the  arrangement  constitutes  a  financing  transaction,  where  the  transaction  is 
measured at the present value of the future receipts discounted at a market rate of interest. 

Such assets are subsequently carried at amortised cost using the effective interest method. 

At the end of each reporting period financial assets measured at amortised cost are assessed for objective 
evidence of impairment. If an asset is impaired the impairment loss is the difference between the carrying 
amount and the present value of the estimated cash flows discounted at the asset’s original effective interest 
rate. The impairment loss is recognised in the consolidated income statement. 

The Company applies the simplified approach in calculating the expected credit losses (ECLs) as permitted 
by IFRS 9. Changes in credit risk is not tracked but instead a loss allowance is recognised at each reporting 
date based on the financial asset’s lifetime ECL. 

If  there  is  a  decrease  in  the  impairment  loss  arising  from  an  event  occurring  after  the  impairment  was 
recognised the impairment is reversed. The reversal is such that the current carrying amount does not exceed 
what  the  carrying  amount  would  have  been  had  the  impairment  not  previously  been  recognised.  The 
impairment reversal is recognised in the consolidated income statement. 

Financial assets are derecognised when (a) the contractual rights to the cash flows from the asset expire or 
are  settled,  or  (b)  substantially  all  the  risks  and  rewards  of  the  ownership  of  the  asset  are  transferred  to 
another party or (c) despite having retained some significant risks and rewards of ownership, control of the 
asset has been transferred to another party who has the practical ability to unilaterally sell the asset to an 
unrelated third party without imposing additional restrictions 

ii) Financial liabilities 

Basic financial liabilities, being trade and other payables, are initially recognised at transaction price, unless 
the arrangement constitutes a financing transaction, where the debt instrument is measured at the present 
value of the future receipts discounted at a market rate of interest. 

Trade payables are obligations to pay for goods or services that have been acquired in the ordinary course 
of business from suppliers. Accounts payable are classified as current liabilities if payment is due within one 
year or less. If not, they are presented as non-current liabilities. Trade payables are recognised initially at 
transaction price and subsequently measured at amortised cost using the effective interest method. 

Financial liabilities are derecognised when the liability is extinguished, that is when the contractual obligation 
is discharged, cancelled or expires. The Company does not hold or issue derivative financial instruments. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

26 

Notes to the financial statements for the year ended 31 December 2020 

2 

Summary of significant accounting policies (continued) 

2.10 

Financial instruments (continued) 

iii) Offsetting 

Financial assets and liabilities are offset and the net amounts presented in the financial statements when 
there is an enforceable right to set off the recognised amounts and there is an intention to settle on a net 
basis or to realise the asset and settle to liability simultaneously. 

2.11 

Pensions 

For  defined  contribution  schemes  the  amount  charged  to  the  statement  of  comprehensive  income  is  the 
contribution payable in the year. Differences between the contributions payable in the year and contributions 
actually paid are shown either as accruals or prepayments. 

2.12 

Exceptional items 

The Company has separately identified certain net expenses that are exceptional by either their size or the 
fact that they do not normally occur in the Company’s normal course of business. Such items are recorded 
separately in the Statement of Comprehensive Income and are explained further in note 5. 

3  Financial risk 

Many of the Company’s risks were reduced significantly during 2019 and 2020 as the Company’s trading 
activities were curtailed. 

3.1    Capital risk management 

The Company monitors capital which comprises all components of equity (i.e. share capital, share premium, 
capital reduction reserve, share option reserve, and retained earnings/losses). Note 21 describes how capital 
is managed in respect of the debt to equity ratio. 

3.2  Financial risk factors 

The Company’s operations exposed it to a variety of financial risks that had included the effects of credit risk, 
liquidity risk and interest rate risk.  The Company had in place a risk management programme that attempted 
to limit the adverse effects on the financial performance of the Company by monitoring levels of debt finance 
and the related finance costs. The Company did not use derivative financial instruments to manage interest 
rate costs and as such, no hedge accounting was applied. 

Given the size of the Company, the directors did not delegate the responsibility of monitoring financial risk 
management to a sub-committee of the Board.  The policies set by the board of directors were implemented 
by the Company’s finance department. 

(a)  Credit risk 

The Company’s credit risk was primarily attributable to its trade receivables balance. The amounts 
presented in the statement of financial position are net of allowances for impairment.  

(c) 

(d) 

Liquidity risk 
Liquidity risk was the risk that an entity will encounter difficulty in meeting obligations associated with 
financial liabilities. The Company’s financial liabilities included its trade and other payables shown in 
Note 10.  

Interest rate cash flow risk 
The  Company  had  interest-bearing  assets.  Interest  bearing  assets  comprised  only  cash  balances, 
which earned interest at floating rates.   

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

27 

Notes to the financial statements for the year ended 31 December 2020 

4         Critical accounting estimates and judgements 

In the preparation of the financial statements the directors must make estimates and assumptions that 
affect the asset and liability items and revenue and expense amounts recorded in the financial statements. 
These  estimates  are  based  on  historical  experience  and  various  other  assumptions  that  the  Board 
believes  are  reasonable  under  the  circumstances.  The  results  of  this  form  the  basis  for  making 
judgements  about  the  carrying  value  of  assets  and  liabilities  that  are  not  readily  available  from  other 
sources. 

a) 

Accounting judgement 

There were no judgments made. 

b) 

Accounting estimate 

Share based payments  
See Note 9 which explains the methods used to estimate the fair value of share options granted.  

5 

Expenses by Nature  

Staff costs   
Loss on disposal of subsidiary undertakings (see below) 
Proposed Transaction expenses (see below) 

2020 
£’000 
86 
- 
77 

2019 
£’000 
93 
201 
275 

The exceptional administrative expenses of £201,000 for the year ended 31 December 2019 related to 
the disposal of subsidiary undertakings as follows: 

Photonstar Technology Limited 
Photonstar LED Limited 
Loss on disposal of subsidiary undertakings 

In 2020 the further expenses were due to the following: 

2020 
£’000 
- 
- 
- 

2019 
£’000 
157 
44 
201 

-  The  exceptional  ‘Proposed  Transaction’  expenses  relate  to  expenses  incurred  on  the 

acquisition of Cizzle Biotechnology Limited that was completed on 14 May 2021.  

6         Investments in subsidiary undertakings 

Opening balance 
Provision for impairment 
Closing balance 

2020 
£’000 
- 
- 
- 

2019 
£’000 
- 
- 
- 

Name 

Enfis Limited 

Country of 
incorporation 

Proportion of ownership 
interest 

Principal 
activities/status 

England and 
Wales 

100% interest in ordinary 
share capital 

Dormant 

Note that since 14 May 2021, Cizzle Biotechnology Limited in a wholly-owned subsidiary of the Company. 

The registered address for ongoing subsidiaries is 6th Floor, 60 Gracechurch Street, London, EC3V OHR. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

28 

Notes to the financial statements for the year ended 31 December 2020 

7       Trade and other receivables 

Trade receivables 
Less: provision for impairment 
Trade receivables (net) 
Social security and other taxes 
Prepayments and other receivables 

2020 
£’000 

4 
- 
4 
2 
- 
6 

2019 
£’000 

17 
- 
17 
11 
3 
31 

Trade and other receivables are non-derivative financial assets with fixed or determinable payments 
that are not quoted in an active market. They are classified as ‘trade and other receivables’ in the 
statement of financial position and are included in current assets, except for maturities greater than 
12 months after the statement of financial position date. These are classified as non-current assets. 
The value of trade receivables shown above, in addition to the value of cash balances on deposit 
with counterparties (see Note 8), represents the Company’s maximum exposure to credit risk. No 
collateral is held as security. 

The fair value of trade and other receivables approximate to the net book values stated above. 

As of 31 December 2020, trade receivables of £Nil (2019: £Nil) were past their due date of receipt. 

Up to two months past due 
Over two months past due 
Total 

  2020 
£’000 

- 
4 
4 

2019 
£’000 

12 
- 
12 

As of 31 December 2020, trade receivables of £Nil (2019: £Nil) were impaired.  The individually impaired 
receivables relate to balances where it has been assessed that the receivable is not expected to be 
recovered.  The ageing of these receivables is as follows: 

Current 

Up to two months past due 
Over two months past due 

2020 
£’000 
- 
- 
- 

The Company’s trade and other receivables above are denominated in Sterling. 

Movements on the provision for impairment of trade receivables are as follows: 

At 1 January 
Utilised 
At 31 December 

2020 
£’000 
- 
- 
- 

2019 
£’000 
- 
- 
- 

2019 
£’000 
- 
- 
- 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

29 

Notes to the financial statements for the year ended 31 December 2020 

8  

Cash and cash equivalents 

Cash on hand & balances with banks        

Company 
2020 
£’000 
84 

Company 
2019 
£’000 
378 

9 

Share capital 

Numbers in 000s 

Nominal value per share 

At 31 December 2018 
Issued 
At 31 December 2019 and  
31 December 2020 

  Number of shares in issue 

New ordinary  
shares 
0.01p 

Deferred 
A' shares 
0.99p 

1,262,221 
11,146,221 

225,158 
- 

12,408,442 

225,158 

The following table reconciles the total nominal value of the shares in issue: 

Nominal value per share 

Total nominal value of shares in issue 
New ordinary  
Total 
shares 
0.01p 
£000 

Deferred 
A' shares 
0.99p 
£000 

£000 

At 31 December 2018 

Issued 
At 31 December 2019 and  
31 December 2020 

126 

1,115 

1,241 

2,229 

- 

2,355 

1,115 

2,229 

3,470 

The following table reconciles the movements in share capital during the year: 

At 31 December 2018 
Issued 
At 31 December 2019 and  
31 December 2020 

£000 

2,355 
1,115 

3,470 

Share 
capital 

Share 
premium 

Share 
capital 
reduction 
reserve 
£000 

10,081 
- 

Total 

£000 

21,242 
1,161 

£000 

8,806 
46 

8,852 

10,081 

22,403 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

30 

Notes to the financial statements for the year ended 31 December 2020 

9 

Share capital (continued) 

In 2020 no shares were issued. During 2019 there were the following share issues: except as noted below, 
all share issues were for cash consideration. 

2019 

January 
February 
March 
May 
Total issued 

No of shares 
issued  
000s 

620,000 
1,750,000 
1,700,000 
7,076,221 
11,146,221 

Issue price 
per share 
Pence 

0.02p 
0.01p 
0.012p 
0.0125p 

On 12 March 2019 the Company issued broker warrants to subscribe for Ordinary Shares equal to 3% of the 
issued share capital of the Company at a fixed price of 0.01p per share valid for three years until 12 March 
2022. The fair value attributed to these warrants is £45,000 and has been accounted for as a cost to the 
Company and a reduction of the share premium account (see statement of changes in equity on page 21). 
On 19 June 2019 a variation deed enabled the warrant holder to subscribe for 3% of the Company’s enlarged 
share capital, taking into account for the calculation of any further issuance of shares in the Company up to 
the Date of Admission of the Company’s shares to trading on AIM or any other EU Recognised Investment 
Exchange following completion of a Reverse Takeover of the Company. The exercise period was amended 
to  the  earlier  of  the  date  of  any  Admission  of  the  Company’s  shares  to  AIM  or  any  other  EU  recognised 
Investment Exchange or 12 March 2022. The company also understands that these broker warrants have 
subsequently been acquired by Mr Antos Glogowski. At 31 December 2020 none of these warrants have 
been exercised. 

Employee share schemes 

a.  Deferred payment share purchase plan 

The Company has a deferred payment share purchase plan which enables the funding of share purchases 
in the Company by executive directors and other employees. There are no current applications to purchase 
shares through this plan (2019: Nil applications). 

b.  Share options 

The  Company  has  an  Enterprise  Management  Incentive  Share  Option  Scheme  (EMI  Scheme)  and  an 
Executive Share Option Scheme. 

During 2020 no share options were granted to directors.  

The exercise terms of all granted options as at 31 December 2019 are summarised below: 

Date of grant 

2015 
2016 
2017 

 Number of 
options 

150,000 
400,000 
250,000 

Exercise price 
(pence per 
share) 
5 
1.85 
1.00 

Exercise 
dates from 
2017 
2017 
2018 

The number and weighted average exercise price of the options that were exercisable at 31 December 2020 
were 800,000 and 2.2p respectively (2019: 800,000 and 2.2p). 

Movements in the number of share options outstanding and their related weighted average exercise prices 
are as follows: 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

31 

Notes to the financial statements for the year ended 31 December 2020 

9 

Share capital (continued) 

At 31 December 2018 
Lapsed 
At 31 December 2019 and 2020 

Average  
exercise price 
(pence per 
share) 
4.6 
3.3 
2.2 

Options 

number 

14,928,864 
(14,128,864) 
800,000 

Share options outstanding at the end of the year have the following expiry dates and exercise prices: 

Expiry date 

2025 
2026 
2027 

Exercise 
price 
(pence per 
share) 
5 
1.85 
1.0 

Options 
2020 

150,000 
400,000 
250,000 
800,000 

Options 
2019 

150,000 
400,000 
250,000 
800,000 

The Company determines the fair value of its share option contracts on the grant date, adjusts this to reflect 
its expectation of the options that will ultimately vest, and then expenses the calculated balance on a straight-
line  basis  through  its  statement  of  comprehensive  income  over  the  expected  vesting  period  with  a 
corresponding credit to its share option reserve. Subsequent changes to the expectation of number of options 
that will ultimately vest are dealt with prospectively such that the cumulative amount charged to the statement 
of comprehensive income is consistent with latest expectations. Subsequent changes in market conditions 
do not impact the amount charged to the statement of comprehensive income. 

The  Company  determines  the  fair  value  of  its  share  option  contracts  using  a  model  based  on  the  Black-
Scholes-Merton methodology. In determining the fair value of its share option contracts, the Company made 
the following assumptions (ranges are provided where values differ across tranches). Expected volatility was 
determined by reference to historical experience. 

See note 23 to these financial statements regarding the share reorganisation and issue of new shares that 
arose on 14 May 2021. 

10 

Financial assets and liabilities 

The  tables  below  analyse  the  carrying  value  of  financial  assets  and  financial  liabilities  in  the  Company’s 
statements of financial position. Further information on the classes that make up each category is provided 
in the notes indicated. The carrying value of each category is considered a reasonable approximation of its 
fair value. All amounts are due within one year.  

Trade receivables 
Prepayments 
Cash and cash equivalents 
Financial assets at amortised cost 

Trade payables 
Accruals 
Financial liabilities at amortised cost 

7 
7 
8 

11 
11 

2020 
£’000 
4 
- 
84 
88 

22 
36 

58 

2019 
£’000 
17 
3 
378 
398 

40 
31 

71 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

32 

Notes to the financial statements for the year ended 31 December 2020 

11        Trade and other payables 

Trade payables 

Accruals 

Total 

12          Deferred income tax 

2019 
£’000 

22 

36 

58 

2019 
£’000 

40 

31 

71 

There is an un-provided deferred tax asset arising on taxable losses of £1.7m (2019: £1.3m). In accordance 
with accounting standards, the deferred tax asset has not been recognised in the financial statements as 
there  will  not  be  sufficient  future  profits  against  which  it  could  be  recovered.    This  position  is  considered 
further  in  Subsequent  Events  Note  23,  and  will  be  reconsidered  again  once  the  Company  demonstrates 
consistent profitability.  

At 31 December 2020 there was no deferred tax liability (2019: £nil).  

13 

Auditor’s remuneration 

During the year the Company obtained the following services from the Company’s auditor as detailed 
below: 

Fees payable for the audit of financial statements 

Total 

14 

Employee benefit expense 

Wages and salaries 

Social security costs 

2020 
£’000 

21 

21 

2019 
£’000 

17 

17 

2020 
£’000 

2019 
£’000 

80 

6 

86 

90 

3 

93 

The  average  number  of  persons  (including  executive  directors)  employed  by  the  Company  during  the 
year was: 

By activity 

Administration and finance 

2020 
Number 

2019 
Number 

3 
3 

3 
3 

During the year, the Company had 3 employees (2019: 3), including the directors. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

33 

Notes to the financial statements for the year ended 31 December 2020 

15 

Directors’ emoluments 

A Syms 

J Treacy 

M Lampshire 

J Freeman 

Salary and Fees 

Social security costs – employer’s national insurance 

Total 

2020 
£’000 

2019 
£’000 

30 

30 

20 

- 

80 

6 

86 

18 

28 

20 

24 

90 

3 

93 

Key  management  personnel  are  defined  as  Directors.  Key  management  compensation  comprises 
salaries and fees set out above and share options set out later in this note.  

The emoluments of the highest paid Director were as follows: 

Aggregate emoluments 

2020 
£’000 

30 

2019 
£’000 

28 

No share options were exercised by the highest paid Director in the year (2019: Nil).  The highest paid 
Director received no share options during the year (2019: Nil). 

No share options were held by any director as at 31 December 2020. 

16 

Income tax 

There was no tax arising in the Company (2019: £Nil). 

Loss before tax on continuing operations 
Tax calculated at the domestic rate applicable of 19% (2019:19%) 
Expenses not deductible for tax purposes 
Tax losses for which no deferred income tax asset was recognised 
Total tax credit  

2020 
£’000 
(306) 
(58) 
14 
44 
- 

2019 
£’000 
(832) 
(185) 
90 
95 
- 

17 

Earnings per share 

Basic loss per share 
Loss from continuing operations 
Weighted average number of ordinary shares 
Basic total comprehensive loss per share 

2020 

2019 

(£306,000) 
12,408,442,268 
(0.0p) 

(£832,000) 
9,091,203,607 
(0.0p) 

Diluted  earnings  per  share  is  calculated  by  dividing  the  loss  attributable  to  ordinary  shareholders  by  the 
weighted average number of ordinary shares outstanding after adjusting these amounts for the effects of 
dilutive potential ordinary shares.  

As the results for the years ended 31 December 2020 and 31 December 2019 are a loss, any exercise of 
share options would have an anti-dilutive effect on earnings per share. Consequently, earnings per share 
and diluted earnings per share are the same and the calculation has not been included. 

As at 31 December 2020, there were share options outstanding over 800,000 shares (2019: 800,000 shares), 
which could potentially have a dilutive impact in the future.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

34 

Notes to the financial statements for the year ended 31 December 2020 

18 

Commitments 

The Company has no leases as at 31 December 2020.  

19 

Related party transactions 

Transactions with directors 

During the year an amount of £20,000 (2019: £29,000) was paid to a related party of 1 director (2019: 2 
directors) in respect of services provided to the Company as follows: 

-  Martin  Lampshire’s  remuneration  of  £20,000  for  services  as  a  Non-Executive  Director  of  the 

Company was paid to Experience Capital Limited. 

20 

Controlling party 

The directors consider there to be no ultimate controlling party. 

21 

Capital management 

In managing its capital structure, the Company’s objective is to safeguard the Company's ability to continue 
as a going concern, managing cash flows so that it can continue to provide returns for shareholders. The 
Company makes adjustments to its capital structure in the light of changes in economic conditions and the 
requirements of the Company’s businesses. The Board has sought to maintain low levels of borrowing to 
reflect the development stage of the Company’s businesses. Over time as the Company’s businesses mature 
and become profitable the Board is likely to make increased use of borrowing facilities to fund working capital. 
In order to maintain or adjust the capital structure, the Company may issue new shares or seek additional 
borrowing facilities. The Company monitors capital on several bases including the debt to equity ratio. This 
ratio  is  calculated  as  debt  ÷  equity.  Debt  is  calculated  as  total  borrowings  as  shown  in  the  consolidated 
statement  of  financial  position.  Equity  comprises  all  components  of  equity  as  shown  in  the  consolidated 
statement of financial position. The debt-to-equity ratio at 31 December 2020 and 31 December 2019 was 
as follows: 

Total debt 
Total equity 
Debt-to-equity ratio 

22 

Reserves 

2020 
£’000 
- 
32 
00.0% 

2019 
£’000 
- 
338 
00.0% 

The following reserves describe the nature and purpose of each reserve within equity: 

a. 

Capital reduction reserve 

The capital reduction reserve set out in the Statement of Changes in Equity arose in 2014 when the 
nominal value of each share was reduced from 10p to 1p.  

b. 

Share premium 

The amount subscribed for each share in excess of nominal value. 

c. 

Share option 

The accumulated expense arising during their vesting period of share options granted to directors and 
employees.  

d. 

Accumulated losses 

All other net losses and gains not recognised elsewhere. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bould Opportunities PLC (to be renamed Cizzle Biotechnology Holdings PLC) 

35 

Notes to the financial statements for the year ended 31 December 2020 

23 

Events after the Reporting Period 

As mentioned in the Chairman’s Statement, on 14 May 2021 the Company completed the acquisition of 
Cizzle  Biotechnology  Limited.  The  Company’s  name  is  in  the  process  of  being  changed  to  Cizzle 
Biotechnology Holdings plc and the Company’s shares were admitted to the Standard Listing segment 
of the Official List and to trading on the Main Market of the London Stock Exchange. The Company’s 
shares  began  trading  at  8.00  a.m.  on  14th  May  2021  under  the  ticker  CIZ  (ISIN:GB00BNG2VN02), 
initially under the name of Bould Opportunities plc until the change of name to Cizzle Biotechnology 
Holdings plc, approved by shareholders at a General Meeting on 13 May 2021, is effective. 

Cizzle Biotechnology is in the early stages of developing a blood test for the early detection of a majority 
of the different forms of lung cancer. Its proof-of-concept prototype test is based on the ability to detect 
a stable plasma biomarker, a variant of C1Z1 known as CIZ1B. C1Z1 is a naturally occurring cell nuclear 
protein involved in DNA replication, and the targeted C1Z1B variant is highly correlated with early stage 
lung cancer.  

The Company has completed a placing of 22,000,000 new ordinary shares at 10p per share to raise 
gross proceeds of £2.2 million. The board intends to apply a majority of the net proceeds of the Placing 
towards  the  development  of  the  C1Z1B  biomarker  test  through  to  CE  marking  and/or  FDA  510(k) 
clearance. 

The  Company  has  also  undergone  a  share-re-organisation  whereby  the  Company’s  shares  of 
12,408,442,268 ordinary shares of 0.01p each and 225,158,220 A deferred shares of 0.99p each were 
consolidated on a 500:1 basis into an ordinary share of 5p, which would then be sub-divided into one 
new ordinary share of 0.01p and 499 A Deferred Shares of 0.01p each. 

This  then  resulted  in  24,816,885  New  Ordinary  Shares  in  issue  in  the  Capital  of  the  Company 
(24,816,815  New  ordinary  shares  arising  from  share  re-organisation  plus  70  New  Ordinary  Shares 
arising from fractional entitlements). 

Following  the  share  reorganisation  and  allotment  of  consideration  shares,  Placing  Shares  and  new 
shares,  there  were  253,447,788  ordinary  shares  of  0.01p  each  that  were  admitted  to  the  Standard 
Listing segment of the Official List of the London Stock Exchange on 14 May 2021. 

The Company's Prospectus was published on 23 April 2021 and is available to view on the Company's 
website at http://www.cizzlebiotechnology.com. 

 
 
 
 
 
 
 
 
 
 
Perivan   261275