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OptimizeRx Corporation

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FY2021 Annual Report · OptimizeRx Corporation
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 10-K

☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2021

☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from _________ to ________

Commission file number: 001-38543

OptimizeRx Corporation
(Exact name of registrant as specified in its charter)

Nevada
(State or other jurisdiction of 
incorporation or organization)

400 Water Street, Ste. 200
Rochester, MI
(Address of principal executive offices)

26-1265381
(I.R.S. Employer 
Identification No.)

48307
(Zip Code)

Registrant’s telephone number: 248-651-6568

Securities registered under Section 12(b) of the Exchange Act:

Title of each class
Common Stock, par value $0.001

Trading Symbol
OPRX

Name of each exchange on which registered
Nasdaq Capital Market

Securities registered under Section 12(g) of the Exchange Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☒ No ☐ 

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ☐ No ☒

Indicate by checkmark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of
Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).
Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an
emerging  growth  company.  See  the  definitions  of  “large  accelerated  filer,”  “accelerated  filer,”  “smaller  reporting  company,”  and  “emerging  growth
company” in Rule 12b-2 of the Exchange Act.

☒ Large accelerated filer
☐ Non-accelerated filer

☐   Accelerated filer
☒  Smaller reporting company
☐ Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new
or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control
over  financial  reporting  under  Section  404(b)  of  the  Sarbanes-Oxley  Act  (15  U.S.C.  7262(b))  by  the  registered  public  accounting  firm  that  prepared  or
issued its audit report. ☒

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

State  the  aggregate  market  value  of  the  voting  and  non-voting  common  equity  held  by  non-affiliates  computed  by  reference  to  the  price  at  which  the
common  equity  was  last  sold,  or  the  average  bid  and  asked  price  of  such  common  equity,  as  of  the  last  business  day  of  the  registrant’s  most  recently
completed second fiscal quarter. $1,030,061,063

Indicate the number of shares outstanding of each of the registrant’s classes of common stock, as of the latest practicable date. 17,875,435 common shares
as of February 24, 2022.

Certain portions of the registrant's definitive proxy statement, in connection with its 2022 Annual Meeting of Shareholders, to be filed with the Securities
and Exchange Commission within 120 days after December 31, 2021, are incorporated by reference into PART III of this Annual Report on Form 10-K.   

DOCUMENTS INCORPORATED BY REFERENCE

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Business
Risk Factors
Unresolved Staff Comments
Properties
Legal Proceedings
Mine Safety Disclosures
Information about Our Executive Officers

TABLE OF CONTENTS

PART I

PART II

Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
Reserved
Management’s Discussion and Analysis of Financial Condition and Results of Operations
Quantitative and Qualitative Disclosures about Market Risk
Financial Statements and Supplementary Data
Changes In and Disagreements With Accountants on Accounting and Financial Disclosure
Controls and Procedures
Other Information
Disclosure Regarding Foreign Jurisdictions that Prevent Inspections

PART III

Directors, Executive Officers and Corporate Governance
Executive Compensation
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
Certain Relationships and Related Transactions, and Director Independence
Principal Accountant Fees and Services

Item 1.
Item 1A.
Item 1B.
Item 2.
Item 3.
Item 4.
Item 4.1

Item 5.
Item 6.
Item 7.
Item 7a.
Item 8.
Item 9.
Item 9A.
Item 9B.
Item 9C

Item 10.
Item 11.
Item 12.
Item 13.
Item 14.

Item 15.
Item 16.

Exhibits and Financial Statement Schedules
Form 10-K Summary

PART IV

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Forward-Looking Statements

PART I

This Annual Report on Form 10-K contains statements that relate to future events and expectations and, as such, constitute forward-looking statements,
within  the  meaning  of  the  Private  Securities  Litigation  Reform  Act  of  1995.  Certain  statements,  other  than  purely  historical  information,  including
estimates, projections, statements relating to our strategies, outlook, business and financial prospects, business plans, objectives, and expected operating
results,  and  the  assumptions  upon  which  those  statements  are  based,  are  “forward-looking  statements.”  These  forward-looking  statements  generally  are
identified by the words “believes,” “project,” “expects,” “anticipates,” “estimates,” “intends,” “strategy,” “plan,” “may,” “will,” “would,” “will be,” “will
continue,” “will likely result,” and similar expressions. Forward-looking statements are based on current expectations and assumptions that are subject to
risks  and  uncertainties  which  may  cause  actual  results  to  differ  materially  from  the  forward-looking  statements.  Forward-looking  statements  are  not
guarantees of future performance. Although OptimizeRx believes that the expectations reflected in any forward-looking statements are based on reasonable
assumptions,  these  expectations  may  not  be  attained  and  it  is  possible  that  actual  results  may  differ  materially  from  those  indicated  by  these  forward-
looking statements due to a variety of risks, uncertainties and changes in circumstances, many of which are beyond OptimizeRx’s control.

For a discussion of some of the specific factors that could cause actual results to differ materially from the information contained in this report, see the
following  sections  of  this  report:  Part  I,  Item  1A.  "Risk  Factors,"  Part  II,  Item  7.  "Management’s  Discussion  and  Analysis  of  Financial  Condition  and
Results of Operations," including the disclosures under "Critical Accounting Policies." Market projections are subject to the risks discussed in this report
and other risks in the market. OptimizeRx disclaims any intention or obligation to update publicly any forward-looking statements, whether in response to
new information, future events or otherwise, except as required by applicable law.

Unless otherwise specified or the context otherwise requires, when used in this Annual Report on Form 10-K, the terms “we,” “our,” “us,” “OptimizeRx,”
or the “Company” refer to OptimizeRx Corporation and its subsidiaries.

Item 1. Business

Overview

OptimizeRx  is  a  digital  health  technology  company  enabling  care-focused  engagement  between  life  sciences  organizations,  healthcare  providers,  and
patients at critical junctures throughout the patient care journey. Connecting over 60% of U.S. healthcare providers and millions of their patients through an
intelligent technology platform embedded within a proprietary point-of-care network, OptimizeRx helps patients start and stay on their medications. 

We are a Nevada corporation organized in September 2008.  We conduct our operations through our wholly-owned subsidiaries, OptimizeRx Corporation, a
Michigan corporation, CareSpeak Communications, Inc., a New Jersey corporation, CareSpeak Communications, D.O.O, a controlled foreign corporation
incorporated in Croatia, RMDY Health, Inc. a Delaware corporation, and Cyberdiet, a controlled foreign corporation incorporated in Israel.

1

 
 
 
 
 
 
 
 
 
 
 
2021 Company Highlights

1. Our net revenue increased to a record $61.3 million in 2021, a 42% increase over 2020.
2. Our net revenue increased to a record $20.3 million in Q4 2021, up 24% over Q4 2020.
3. Achieved positive cashflow from operations of $0.7 million for the year ended December 31, 2021.
4. We generated net income of $0.4 million in 2021 as compared to a loss of $2.2 million in 2020.
5. Completed the integration work for our previous acquisitions and paid the last earnout payment related to the acquisitions.
6. Raised an additional $70.7 million in capital in a public offering in February 2021.
7. Enhanced our leadership team by adding Edward Stelmakh as Chief Operating Officer and Chief Financial Officer.
8. Expanded our pipeline for our new Real-World Evidence (“RWE”) messaging solution that we launched in the second quarter of 2021.
9. We  announced  the  launch  of  our  new  Therapy  Initiation  Workflow,  which  enables  pharmaceutical  manufacturers  to  execute  market  access

strategies, and particularly supports the fast-growing area of specialty medications.

10. We  launched  multiple  Evidence-Based  Physician  Engagement  programs  and  in  December,  the  solution  was  recognized  as  one  of  the  most

innovative products for life sciences by PM 360 magazine.

11. We were listed as one of the Americas’ Fastest Growing Companies by Deloitte and the Financial Times
12. We were added to the S&P SmallCap 600 Index in October 2021.

Principal Solutions and Applications

Our principal solutions and applications can be summarized as follows:

● Financial  Messaging  –  Our  integrated  financial  messaging  platform  is  a  revolutionary  virtual  “Patient  Support  Center”  that  allows  doctors  and
staff to access a universe of sample vouchers, co-pay coupons and other patient support options through their EMR and/or e-Prescribe systems. It
allows them to search, print or electronically dispense directly to patients and a national network of pharmacies. Our platform eliminates the need
for  physicians  to  manage  and  store  physical  drug  samples  by  offering  a  more  convenient  and  efficient  way  to  allocate,  administer  and  track
samples and co-pay savings for their patients. Today, nearly 60% of doctor offices ban or limit drug representatives and the samples they offer.
While samples are still valuable, our solution addresses the fact that many healthcare systems and doctors are looking for an easier, more effective
way to increase affordable access and adherence to their prescribed branded medications.

● Brand  and  Therapeutic  Support  Messaging  –  Our  brand  messaging  services  include  a  variety  of  brand  awareness  and  therapeutic  support
messaging  services  that  can  be  tailored  to  meet  the  needs  of  a  brand.  These  messages  can  include  brand  awareness  messages,  reminder  ads,
therapeutic support messages and unbranded messages that can be targeted by specialty, diagnostic code and other criteria. Brand messaging is
highly complementary to our core financial messaging solution. Historically, we have sold brand messaging based on specific solutions offered by
our Electronic Health Record (“EHR”) partners, but we have developed our own proprietary banner messaging system, rolled this solution out in
2017, and expanded it since then. We also developed our own therapeutic support messaging system and launched it with our first partner in late
2018. We believe brand messaging represents a significant growth opportunity for us.

● Brand  Support  –  Our  brand  support  is  focused  on  educating  and  working  with  pharmaceutical  manufacturers  on  identifying,  formulating,  and
implementing new eRx media strategies for promoting their solutions. Our services include: 1) Drug File Integration - a service designed to better
insure that manufacturers’ drugs are present in every ePrescribing platform available; 2) Sales Force Training – a service to educate the extended
field sales force on this new integrated solution and what to look for within their client base to insure maximum exposure of their brands; and 3)
Strategy Development – a service that assists pharmaceutical manufacturers in identifying and building a competitive strategy to take advantage of
this new digital frontier. Currently, this activity results in less than 10% of our revenue, but represents a significant growth opportunity for us.

2

 
 
 
 
 
 
 
 
 
 
 
 
● Patient Engagement – Our patient engagement activities arose out of our acquisition of CareSpeak Communications in October 2018, followed by
our acquisition of RMDY Health in 2019. Our technology solution provides digital messaging services through our cloud based Mobile Health
Messenger (“MHM”) Platform. We provide interactive health messaging for improved medication adherence and care coordination. Our HIPAA-
compliant,  automated,  mobile  messaging  platform  allows  pharmaceutical  manufactures  and  related  entities  to  directly  engage  with  patients  to
improve  regimen  compliance.  We  also  deliver  patient  programs  with  treatment  and  affordability  information,  lifestyle  and  condition  trackers,
internet device connectivity, forms and surveys, with this all supported by a wide range of communication capabilities delivered via chat, bots,
audio and telehealth. We enable this functionality for our customers, with our solutions delivering a variety of intervention mechanisms that help
treat chronic conditions, such as diabetes and heart disease.

● Evidence-Based  Physician  Engagement  –  Our  evidence-based  physician  engagement  solution  uses  predictive  analytics  via  machine  learning
methods  applied  to  real-world  data  (RWD)  to  assist  healthcare  providers  (HCPs)  in  identifying  patients  who  may  be  qualified  for  specific
therapies, raise awareness of patient access pathways, and identify early indicators of non-adherence among patient populations. This real-world
evidence  (RWE)  solution  translates  into  better  support  for  providers  as  they  look  to  make  the  best  treatment  decisions  for  their  patients.  This
solution  has  a  “patient-first”  focus,  helping  manufacturers  identify  which  HCPs  to  engage  by  first  identifying  if  they  have  patients  in  need  of
support, based on where they are in their care journey and disease state. This needs assessment is completed in real time using the AI technology
on our Therapy Initiation and Persistence Platform, reducing delay in support delivery caused by traditional applications of RWD in engagement
activities.

● Therapy  Initiation  Workflow  –  the  therapy  initiation  workflow  is  a  digital  solution  focused  on  accelerating  patient  access  to  treatments  where
time-consuming  medical  documentation  is  required  of  HCPs  prior  to  pharmacies  dispensing  prescribed  drugs.  The  new  platform  enhancement
particularly  supports  the  fast-growing  area  of  specialty  medications.  In-line  with  the  major  digitization  paradigm  shift  across  healthcare,  this
technology  enhancement  allows  life  sciences  companies  to  simplify  therapy  initiation  by  presenting  HCPs  with  a  fully  electronic  option
synchronizing enrollment, benefits verification, prior authorization, and patient support onboarding.

Sales and Marketing Update

Our  sales  team  continues  to  expand  our  business  with  existing  and  new  clients,  strategically  focused  on  the  digital  connection  of  care  between  the
pharmaceutical industry, physicians, and patients. We continue driving awareness of the increased value of our enterprise platform approach, expanding our
share of customer wallet in reflection of the life sciences budget shift to digital solutions. We have increased the depth and breadth of our business across
existing client product portfolios by maximizing the utilization of our network.  We are expanding our business by making significant enhancements to our
platform and network to digitize pharmaceutical access solutions in support of major industry paradigm shift towards improving patient care and adherence
through technology. In 2021 we announced the launch of our new Therapy Initiation Workflow, a digital solution focused on accelerating patient access to
treatments  where  time-consuming  medical  documentation  is  required  of  HCPs  prior  to  pharmacies  dispensing  prescribed  drugs.  The  new  platform
enhancement particularly supports the fast-growing area of specialty medications. Our team continues to work on converting current clients from individual
solutions to enterprise platform deals with access to our full set of solutions across our network. These enterprise deals enable us to increase our revenue
per customer and give us a more predictable and consistent revenue stream.    

3

 
 
 
 
 
 
 
 
 
 
 
 
 
 
In 2021, we delivered on our marketing strategy to focus more heavily on strategic content and expansion beyond specific product marketing efforts with a
10x  increase  in  engagement  with  our  content,  resulting  in  higher  brand  visibility  through  organic,  non-paid  channels.  Our  efforts  remain  focused  on
cementing  our  image  as  a  strategic  partner  with  our  buyers,  and  we  have  completed  a  positioning  expansion  effort  to  better  capture  the  value  of  our
platform  with  our  buyers  in  light  of  the  innovations  we  have  deployed  over  the  last  two  years.  Additionally,  we  hosted  a  series  of  webinars  featuring
industry leaders in 2021 to foster collaboration, and we hosted our second annual Innovate4Outcomes event, partnering with patient advocacy groups to
brainstorm actionable solutions to address standards of care and equal access to treatment for patients.

We have continued building marketing strategy momentum in 2021 with increased industry visibility that we expect to expand in 2022.

Operational Update

In 2021, we continued expansion of our network, driving a broad mix of HCP specialties in alignment with our commercial customer therapeutic portfolios.
 The introduction of Real-World Evidence and expansion into omni-channel engagement brought engagement opportunities beyond the point of prescribe,
enabling access to life saving therapies.  Leveraging AI, we engage providers and patients with the right insight at precisely the right time, helping to drive
improved outcomes.  

Technology Update

To support our growth and to further improve the efficiency of our systems, we have moved our core platforms to Amazon Web Services. As a result of our
acquisitions in 2018 and 2019, we now have tech teams based in both Croatia and Israel, in addition to our core team in the U.S., to help develop further
applications throughout the organization.

All  application  code,  libraires,  and  3rd  party  services  are  maintained  at  high  levels,  with  an  ongoing  regimen  of  patches  and  upgrades  and  version
synchronization to ensure both forward looking and reverse compatibility.

Systems  enhancements  in  2021  included  upgrades  and  full  documentation  of  processes  and  procedures  and  security  implementation  in  support  of  full
Enterprise HITRUST Certification in 2022, as well as for ongoing Sarbanes Oxley, HIPAA, customer assessments and other needs.

All  systems  are  fully  scalable,  automatically  based  on  various  metrics,  thresholds,  and  are  live-live  in  multiple  redundant  geographically  disparate  data
centers.

Applications  introduced  are  modular  and  flexible  allowing  enhancements  and  new  solutions  to  flow  through  the  system  which  results  in  rapid
implementation by our partners that typically only takes a few weeks to one quarter.

Competition

Our  platforms  face  competition  from  numerous  other  companies,  both  in  attracting  users  and  in  generating  revenue  from  advertisers  and  sponsors.  We
compete for users with online services and websites that provide savings on medications and healthcare products, including both commercial sites and not-
for-profit sites. We compete for advertisers and sponsors with health-related web sites, general purpose consumer web sites that offer specialized health
sub-channels, other high-traffic web sites that include both healthcare-related and non-healthcare-related content and services, search engines that provide
specialized health searches, and advertising networks that aggregate traffic from multiple sites.

Our messaging platform competes broadly in the highly competitive pharmaceutical and life sciences digital marketing industry that is dominated by large
well-known companies with established names, solid market niches, wide arrays of product offerings and marketing networks. Many of our competitors
have greater financial, technical, product development, marketing and other resources than we do. These organizations may be better known than we are
and have more customers or users than we do. Our messaging offerings compete for pharmaceutical budgets with a variety of other forms of advertising
and promotion. Our platform is unique in its ability to reach prescribers directly in their workflow through their EHR. The primary direct competitor in our
financial messaging solution is ConnectiveRx. We generally compete on the basis of several factors, including size of our network, quality of our service,
our ability to target specific customer needs, and to a lesser extent, price. We believe we compete favorably on these metrics. For more information on risks
relating to our competition, see  Item 1A. Risk Factors.

4

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Intellectual Property

We  own  a  number  of  patents  important  to  our  business,  and  we  expect  to  continue  to  file  patent  applications  to  protect  our  research  and  development
investments in new products. As of December 31, 2021 we held 3 patents and several pending patent applications, including foreign counterpart patents
and foreign applications. For the United States, patents may last 20 years from the date of the patent’s filing, depending upon term adjustments made by the
patent office. In addition, we hold numerous trademarks in the United States and other countries. We also have licenses to intellectual property for the use
and sale of certain of our solutions.

OPTIMIZERx, TELAREP, CareSpeak, RMDY Wellness Layers, Diet Watch, and SampleMD are our licensed trademarks.

We obtain other intellectual property rights and/or licenses used in connection with our business when practical and appropriate. Historically, we have done
so both organically, through commercial relationships and in connection with acquisitions.

Government Regulation

The healthcare industry and, in particular, our customers and partners are subject to applicable U.S. federal, state and local laws and regulations, including
those governing fraud, abuse, privacy and security. Many of these laws and regulations are complicated and how they might apply to us, our customers, our
partners, or the specific services and relationships we have with our customers and partners are not always well-defined. Our failure, or perceived failure, to
accurately apply, or comply with, these laws and regulations could subject us to significant fines and liability, result in reputational harm, and adversely
affect our business. See Item 1A. Risk Factors for more information on the impact of Government Regulations on OptimizeRx.

Employees

As of December 31, 2021, we had 82 full-time employees in the U.S, as well as 15 full-time international employees, and no part-time employees. None of
our  employees  are  represented  by  a  labor  union  or  collective  bargaining  agreement  with  respect  to  their  employment  with  us.  The  majority  of  our
employees work remotely and are geographically distributed across the United States, Israel and Croatia. We supplement our workforce with contractors in
the United States and internationally on an as needed basis. We consider our relationship with our employees to be good and have not experienced any
work stoppages.

We are dedicated to maintaining an environment where everyone feels valued, and we celebrate both the differences and similarities among our people. We
also believe that diversity in all areas, including cultural background, experience and thought, is essential in making our Company stronger. In  2021  we
introduced a Diversity, Equity & Inclusion Committee, which is actively engaged in improving our culture, hiring practices and education. In 2021, we
committed to the Parity Pledge – pledging to interview and consider at least one qualified woman and underrepresented minority for every open role, VP or
higher.

We prioritize recruiting, retaining, and incentivizing a highly qualified, diverse workforce and we incentivize selected employees through the granting of
stock-based awards for compensation and performance and cash-based bonus awards for performance.

We have increased our focus on training and development for our current employees. We offer learning and development opportunities and other resources
to support our employees in achieving and enhancing their development objectives. We equip our managers with the skills and tools to provide ongoing
coaching and feedback so employees can maximize their performance and potential, delivering success for the company and the employee.

Available Information

Our  Internet  address  is  www.optimizerx.com.  The  information  on  the  website  is  not  and  should  not  be  considered  part  of  this  Form  10-K  and  is  not
incorporated by reference in this Form 10-K. The website is, and is only intended to be, for reference purposes only. We make available free of charge on or
through our website our Annual Report on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K, and amendments to those reports
filed  or  furnished  pursuant  to  Section  13(a)  or  15(d)  of  the  Securities  Exchange  Act  of  1934,  as  amended  (the  “Exchange  Act”)  as  soon  as  reasonably
practicable  after  we  electronically  file  such  material  with,  or  furnish  it  to,  the  Securities  and  Exchange  Commission  (the  “SEC”).  In  addition,  we  will
provide, at no cost, paper or electronic copies of our reports and other filings made with the SEC. Requests should be directed to: Attention: Secretary,
OptimizeRx Corporation, 400 Water Street, Suite 200, Rochester, MI 48307.

5

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Item 1A. Risk Factors

Risks Relating to Our Business

Because we have historically experienced losses, if we are unable to achieve profitability, our financial condition and company could suffer.

While we were profitable for the full year of 2021, since the inception of our business we have historically incurred losses as a result of investing in future
growth.  We  incurred  losses  in  2019  and  2020  as  a  result  of  our  increased  spending  to  build  the  organization  to  support  expected  future  growth  –  both
through  additional  new  hires,  as  well  as  through  acquisitions.  While  we  have  increased  revenues  significantly,  we  have  not  yet  consistently  achieved
profitability due to these investments and non-cash expenses. Our ability to achieve consistent profitability depends on our ability to generate sales through
our technology platform and advertising model, while maintaining reasonable expense levels. If we do not achieve sustainable profitability, it may impact
our ability to continue our operations.

The global pandemic may disrupt our business or the business of our customers

In December 2019, a novel strain of corona virus, which causes the infectious disease known as COVID-19 was reported. The World Health Organization
declared COVID-19 a Public Health Emergency and Global Pandemic. COVID-19 has had, and continues to have, a severe impact on economies around
the world, in particular in the healthcare industry in which we operate. We have taken steps to modify our business practices and mitigate the impact of the
pandemic on us, and may take further precautions as required by government authorities or to protect the health of our employees, customer, and partners -
but there can be no assurance that such steps will be successful, or that our business operations, or the operations of our customers or partners will not be
materially and adversely affected by the consequences of the pandemic. This could materially impact our results of operations, cash flows, and financial
condition.

We may be unable to support our technology to further scale our operations successfully.

Our  plan  is  to  grow  rapidly  through  further  integration  of  our  technology  in  electronic  platforms.  Our  growth  will  place  significant  demands  on  our
management  and  technology  development,  as  well  as  our  financial,  administrative  and  other  resources.  We  cannot  guarantee  that  any  of  the  systems,
procedures and controls we put in place will be adequate to support the commercialization of our operations. Our operating results will depend substantially
on the ability of our officers and key employees to manage changing business conditions and to implement and improve our financial, administrative and
other resources. If we are unable to respond to and manage changing business conditions, or the scale of our solutions, services and operations, then the
quality of our services, our ability to retain key personnel and our business could be harmed. 

Developing and implementing new and updated applications, features and services for our portals may be more difficult than expected, may take longer
and cost more than expected and may not result in sufficient increases in revenue to justify the costs.

Attracting and retaining users of our portals requires us to continue to improve the technology underlying those portals and to continue to develop new and
updated applications, features and services for those portals. If we are unable to do so on a timely basis or if we are unable to implement new applications,
features and services without disruption to our existing ones, we may lose potential users and clients. The costs of development of these enhancements may
negatively impact our ability to achieve profitability.

We  rely  on  a  combination  of  internal  development,  strategic  relationships,  licensing  and  acquisitions  to  develop  our  portals  and  related  applications,
features and services. Our development and/or implementation of new technologies, applications, features and services may cost more than expected, may
take longer than originally expected, may require more testing than originally anticipated and may require the acquisition of additional personnel and other
resources. There can be no assurance that the revenue opportunities from any new or updated technologies, applications, features or services will justify the
amounts spent.

6

 
 
 
 
 
 
 
 
 
 
 
 
 
Any failure to offer high-quality customer support for our portals may adversely affect our relationships with our customers and harm our financial
results.

Once our solutions are implemented, our customers use our support organization to resolve technical issues relating to our solutions. In addition, we also
believe  that  our  success  in  selling  our  solutions  is  highly  dependent  on  our  business  reputation  and  on  favorable  recommendations  from  our  existing
customers. Any failure to maintain high-quality customer support, or a market perception that we do not maintain high-quality support, could harm our
reputation, adversely affect our ability to maintain existing customers or sell our solutions to existing and prospective customers, and harm our business,
operating results and financial condition.

We may be unable to respond quickly enough to accommodate short-term increases in customer demand for support services. Increased customer demand
for these services, without corresponding revenues, could also increase costs and adversely affect our operating results.

We are dependent on a concentrated group of customers.

Our revenues are concentrated in less than 50 customers, primarily large pharmaceutical manufacturers. Loss of one or more of our larger customers could
have a negative impact on our operating results. In both 2021 and 2020, we had three customers that each represented slightly over 10% of our revenues;
however only one customer represented over 10% of our revenues in both years.

We expect that we will continue to depend upon a relatively small number of customers for a significant portion of our total revenues for the foreseeable
future. The loss of any of these customers or groups of customers for any reason, or a change of relationship with any of our key customers could cause a
material decrease in our total revenues.

Additionally, mergers or consolidations among our customers in the healthcare industry could reduce the number of our customers and could adversely
affect our revenues and sales. In particular, if our customers are acquired by entities that are not also our customers, that do not use our solutions or that
have more favorable contract terms with competitors and choose to discontinue, reduce or change the terms of their use of our solutions, our business and
operating results could be materially and adversely affected.

 If we are unable to maintain our contracts with electronic prescription platforms, our business will suffer.

We are reliant upon our contracts with leading electronic prescribing platforms and electronic health record systems to generate our revenues received from
customers Such arrangements subject us to a number of risks, including the following:

● Our contract partners may experience financial, regulatory or operational difficulties, which may impair their ability to focus on and fulfill their

contract obligations to us;

● Legal disputes or disagreements, including the ownership of intellectual property, may occur with one or more of our partners and may lead to

lengthy and expensive litigation or arbitration;

● Significant changes in a partner’s business strategy may adversely affect a partner’s willingness or ability to satisfy obligations under any such

arrangement; and

● A partner could terminate the partnership arrangement, which could negatively impact our ability to sell our solutions and achieve revenues.

We will need to maintain these relationships as well as diversify them. The inability to do so could adversely impact our business. We generated 53.9% and
52.7% of our revenue through our largest partner in 2021 and 2020, respectively.

7

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Our agreements with electronic prescription platforms and electronic health record systems are subject to audit.

Our agreements with our partners provide for revenue sharing payments to the platform partners based on the revenue we generate through the platform.
These payments are subject to audit by our partners, at their cost, and if there is a dispute as to the calculation, we may be liable for additional payments. If
an underpayment is determined to be in excess of a certain amount, for example 10%, some agreements would require us to pay for the cost of the audit, as
well.

Our future growth depends on our ability to attract, retain customers, and the loss of existing customers, or failure to attract new ones, could adversely
impact our business and future prospects.

We  currently  work  with  many  leading  pharmaceutical  companies,  medical  device  manufacturers,  associations,  and  other  companies.  While  we  have
experienced customer growth, this growth may not continue at the same pace in the future or at all. Achieving growth in our customer base may require us
to engage in increasingly sophisticated and costly sales and marketing efforts that may not result in additional customers. We may also need to modify our
pricing model to attract and retain such customers. If we fail to attract new customers or fail to maintain or expand existing relationships in a cost-effective
manner, our business and future prospects may be materially and adversely impacted.

Actual or perceived failures to comply with applicable laws and regulations that affect the healthcare industry, including data protection, privacy and
security, fraud and abuse laws, regulations, standards and other requirements could adversely affect our business, results of operations, and financial
condition.

The global data protection landscape is rapidly evolving, and we are or may become subject to numerous state, federal and foreign laws, requirements and
regulations governing the collection, use, disclosure, retention, and security of personal information, including health-related information. This evolution
may create uncertainty in our business, affect our ability to operate in certain jurisdictions or to collect, store, transfer, use and share personal information,
necessitate the acceptance of more onerous obligations in our contracts, result in liability or impose additional costs on us. The cost of compliance with
these laws, regulations and standards is high and is likely to increase in the future. Any failure or perceived failure by us to comply with federal, state or
foreign laws or regulation, our internal policies and procedures or our contracts governing our processing of personal information could result in negative
publicity, government investigations and enforcement actions, claims by third parties, and damage to our reputation, any of which could have a material
adverse effect on our operations, financial performance and business.

We also may be bound by contractual obligations and other obligations relating to privacy, data protection, and information security that are more stringent
than  applicable  laws  and  regulations.  The  costs  of  compliance  with,  and  other  burdens  imposed  by,  laws,  regulations,  standards,  and  other  obligations
relating to privacy, data protection, and information security are significant. Although we work to comply with applicable laws, regulations, and standards,
our contractual obligations and other legal obligations, these requirements are evolving and may be modified, interpreted and applied in an inconsistent
manner from one jurisdiction to another, and may conflict with another or other legal obligations with which we must comply. Accordingly, our failure, or
perceived inability, to comply with these laws, regulations, standards, and other obligations may limit the use and adoption of our solution, reduce overall
demand for our solution, lead to regulatory investigations, breach of contract claims, litigation, and significant fines, penalties, or liabilities for actual or
alleged noncompliance or slow the pace at which we close sales transactions, any of which could harm our business.

The Health Insurance Portability and Accountability Act of 1996, or HIPAA, and the rules promulgated thereunder require certain entities, referred to as
Covered  Entities,  to  comply  with  established  standards,  including  standards  regarding  the  privacy  and  security  of  protected  health  information,  or  PHI.
HIPAA further requires that Covered Entities enter into agreements meeting certain regulatory requirements with their business associates, as such term is
defined by HIPAA, which, among other things, obligate the business associates to safeguard the covered entity’s PHI against improper use and disclosure.
While we are not a Covered Entity and not directly regulated by HIPAA, our customers or distributors might face significant contractual liability pursuant
to  such  an  agreement  if  the  business  associate  breaches  the  agreement  or  causes  the  Covered  Entity  to  fail  to  comply  with  HIPAA.    It  is  possible  that
HIPAA compliance could become a substantial regulatory burden and expense to our operations as we expand our point of care technology solutions to
help patients start and stay on therapies.

8

 
 
 
 
 
 
 
 
 
 
Certain other laws and regulations such as federal and state anti-kickback and false claims laws may apply to us indirectly through our relationships with
our  customers  and  partners.  Violations  can  result  in  considerable  penalties  and  sanctions.  If  we  are  found  to  have  violated,  or  to  have  facilitated  the
violation of such laws, we could be subject to significant penalties.

If we are unable to adhere to the regulatory and competitive climate in which we operate, we could be materially and negatively impacted.

Due to the labyrinth of regulations in healthcare space, state and federal, as well as political sensitivity of healthcare delivery, our business model could be
negatively impacted or fail.

The markets in which we operate are competitive, continually evolving and, in some cases, subject to rapid change.

Our  platforms  face  competition  from  numerous  other  companies,  both  in  attracting  users  and  in  generating  revenue  from  advertisers  and  sponsors.  We
compete for users with online services and websites that provide savings on medications and healthcare products, including both commercial sites and not-
for-profit sites. We compete for advertisers and sponsors with health-related web sites, general purpose consumer web sites that offer specialized health
sub-channels, other high-traffic web sites that include both healthcare-related and non-healthcare-related content and services, search engines that provide
specialized health searches, and advertising networks that aggregate traffic from multiple sites.

Many of our competitors have greater financial, technical, product development, marketing and other resources than we do. These organizations may be
better known than we are and have more customers or users than we do. We cannot provide assurance that we will be able to compete successfully against
these organizations or any alliances they have formed or may form. Since there are no substantial barriers to entry into the markets in which our public
portals participate, we expect that competitors will continue to enter these markets.

Developments in the healthcare industry could adversely affect our business.

Most of our revenue is derived from the healthcare industry and could be affected by changes affecting healthcare spending. We are particularly dependent
on pharmaceutical, biotechnology and medical device companies for our advertising and sponsorship revenue.

General reductions in expenditures by healthcare industry participants could result from, among other things:

● Government regulation or private initiatives that affect the manner in which healthcare providers interact with patients, payers or other healthcare

industry participants, including changes in pricing or means of delivery of healthcare products and services;

● Government regulation prohibiting the use of coupons by patients covered by federally funded health insurance programs;

● Consolidation of healthcare industry participants;

● Reductions or changes in governmental funding for healthcare; and

● Adverse changes in business or economic conditions affecting healthcare payers or providers, pharmaceutical, biotechnology or medical device

companies or other healthcare industry participants.

9

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Even if general expenditures by industry participants remain the same or increase, developments in the healthcare industry may result in reduced spending
in some or all of the specific market segments that we serve or are planning to serve. For example, use of our solutions and services could be affected by:

● Changes in the design of health insurance plans;

● A decrease in the number of new drugs or medical devices coming to market;

● A decrease in marketing expenditures by pharmaceutical or medical device companies, including as a result of governmental regulation or private

initiatives that discourage or prohibit advertising or sponsorship activities by pharmaceutical or medical device companies; and

● Payor pressure to move to generic brands.

In  addition,  our  customers’  expectations  regarding  pending  or  potential  industry  developments  may  also  affect  their  budgeting  processes  and  spending
plans with respect to solutions and services of the types we provide.

The healthcare industry has changed significantly in recent years and we expect that significant changes will continue to occur. However, the timing and
impact of developments in the healthcare industry are difficult to predict. We cannot assure you that the markets for our solutions and services will continue
to exist at current levels or that we will have adequate technical, financial and marketing resources to react to changes in those markets.

If we are unable to manage growth, our operations could be adversely affected.

Our ability to manage growth effectively will depend on our ability to improve and expand operations, including our financial and management information
systems, and to recruit, train and manage personnel. There can be no absolute assurance that management will be able to manage growth effectively. To
manage growth effectively, we will be required to continue to implement and improve our operating and financial systems and controls to expand, train and
manage  our  employee  base.  Our  ability  to  manage  our  operations  and  growth  effectively  will  require  us  to  continue  to  expend  funds  to  enhance  our
operational, financial and management controls, reporting systems and procedures, and to attract and retain sufficient talented personnel.

If we do not properly manage the growth of our business, we may experience significant strains on our management and operations and disruptions in our
business. Various risks arise when companies grow too quickly. If our business grows too quickly, our ability to meet customer demand in a timely and
efficient manner could be challenged. We may also experience development delays as we seek to meet increased demand for our solutions. Our failure to
properly manage the growth that we or our industry might experience could negatively impact our ability to execute on our operating plan and, accordingly,
could have an adverse impact on our business, our cash flow and results of operations, and our reputation with our current or potential customers.

Our  growth  may  be  impacted  by  acquisitions.  We  may  not  be  able  to  identify  suitable  acquisition  candidates,  complete  acquisitions  or  integrate
acquisitions successfully.

Our future growth is likely to depend to some degree on our ability to acquire and successfully integrate new businesses. We may not be able to identify
suitable  acquisition  candidates,  complete  acquisitions,  or  integrate  acquisitions  successfully.  We  may  seek  additional  acquisition  opportunities,  both  to
further diversify our business and to penetrate or expand important product offerings or markets. There are no assurances, however, that we will be able to
successfully identify suitable candidates, negotiate appropriate terms, obtain financing on acceptable terms, complete proposed acquisitions, successfully
integrate  acquired  businesses,  or  expand  into  new  markets.  Once  acquired,  operations  may  not  achieve  anticipated  levels  of  revenues  or  profitability.
Acquisitions involve risks, including difficulties in the integration of the operations, technologies, services and products of the acquired companies and the
diversion of management's attention from other business concerns. Although our management will endeavor to evaluate the risks inherent in any particular
transaction, there are no assurances that we will properly ascertain all such risks. Difficulties encountered with acquisitions could have a material adverse
impact on our business.

10

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Our business and growth may suffer if we are unable to attract and retain key employees.

Our  success  has  been  largely  dependent  on  the  skills,  experience  and  efforts  of  our  key  employees  and  the  loss  of  the  services  of  any  of  our  executive
officers or other key employees, without a properly executed transition plan, could have an adverse effect on us. The loss of any member of our senior
management team or any of our other key employees could damage critical customer relationships, result in the loss of vital knowledge, experience and
expertise,  could  lead  to  an  increase  in  recruitment  and  training  costs  and  make  it  more  difficult  to  successfully  operate  our  business  and  execute  our
business strategy. We may not be able to find qualified potential replacements for these individuals and the integration of potential replacements may be
disruptive to our business. 

Furthermore, our ability to expand operations to accommodate our anticipated growth will also depend on our ability to attract and retain qualified media,
management, finance, marketing, sales and technical personnel. However, competition for these types of employees is intense due to the limited number of
qualified professionals. Our ability to meet our business development objectives will depend in part on our ability to recruit, train and retain top quality
people with advanced skills who understand our technology and business. If we are unable to engage and retain the necessary personnel, our business may
be materially and adversely affected.

We could be subject to economic, political, regulatory and other risks arising from our international operations.

Operating in international markets requires significant resources and management attention and will subject us to regulatory, economic and political risks
that  may  be  different  from  and  incremental  to  those  in  the  United  States.  In  addition  to  the  risks  that  we  face  in  the  United  States,  our  international
operations in Israel and Croatia, may involve risks that could adversely affect our business, including:

● difficulties and costs associated with staffing and managing foreign operations;

● natural or man-made disasters, political, social and economic instability, including wars, terrorism and political unrest, outbreak of disease (such

as the recent outbreak of the novel coronavirus, or COVID-19), boycotts, curtailment of trade, and other business restrictions;

● compliance with United States laws, such as the Foreign Corrupt Practices Act, export controls and economic sanctions, and local laws prohibiting

corrupt payments to government officials;

● unexpected changes in regulatory requirements;

● less favorable foreign intellectual property laws;

● adverse tax consequences such as those related to repatriation of cash from foreign jurisdictions into the United States, non-income related taxes
such  as  value-added  tax  or  other  indirect  taxes,  changes  in  tax  laws  or  their  interpretations,  or  the  application  of  judgment  in  determining  our
global provision for income taxes and other tax liabilities given inter-company transactions and calculations where the ultimate tax determination
is uncertain;

● fluctuations  in  currency  exchange  rates,  which  could  impact  revenues  and  expenses  of  our  international  operations  and  expose  us  to  foreign

currency exchange rate risk;

● profit repatriation and other restrictions on the transfer of funds;

● differing payment processing systems as well as consumer use and acceptance of electronic payment methods, such as payment cards;

● new and different sources of competition;

● different and more stringent user protection, data protection, privacy and other laws; and

● availability of reliable broadband connectivity and wide area networks in targeted areas for expansion.

Our failure to manage any of these risks successfully could harm our international operations and our overall business, as well as results of our operations.

11

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Risks Related to Our Intellectual Property and Technology

We  are  dependent,  in  part,  on  our  intellectual  property.  If  we  are  not  able  to  protect  our  proprietary  rights  or  if  those  rights  are  invalidated  or
circumvented, our business may be adversely affected.

Our  business  is  dependent,  in  part,  on  our  ability  to  innovate,  and,  as  a  result,  we  are  reliant  on  our  intellectual  property.  We  generally  protect  our
intellectual property through patents, trademarks, trade secrets, confidentiality and nondisclosure agreements and other measures to the extent our budget
permits. There can be no assurance that patents will be issued from pending applications that we have filed or that our patents will be sufficient to protect
our  key  technology  from  misappropriation  or  falling  into  the  public  domain,  nor  can  assurances  be  made  that  any  of  our  patents,  patent  applications,
trademarks or our other intellectual property or proprietary rights will not be challenged, invalidated or circumvented. In the event a competitor or other
party successfully challenges our solutions, processes, patents or licenses or claims that we have infringed upon their intellectual property, we could incur
substantial litigation costs defending against such claims, be required to pay royalties, license fees or other damages or be barred from using the intellectual
property at issue, any of which could have a material adverse effect on our business, operating results and financial condition. We cannot assure you that
steps  taken  by  us  to  protect  our  intellectual  property  and  other  contractual  agreements  for  our  business  will  be  adequate,  that  our  competitors  will  not
independently  develop  or  patent  substantially  equivalent  or  superior  technologies  or  be  able  to  design  around  patents  that  we  may  receive,  or  that  our
intellectual property will not be misappropriated.

If  we  are  unable  to  protect  our  proprietary  rights,  we  may  be  at  a  disadvantage  to  others  who  do  not  incur  the  substantial  time  and  expense  we  incur.
Preventing unauthorized use or infringement of our intellectual property rights is inherently difficult. Moreover, it may be difficult or practically impossible
to  detect  theft  or  unauthorized  use  of  our  intellectual  property.  Any  of  the  foregoing  could  have  a  material  adverse  effect  upon  our  business,  financial
condition and results of operations.

Cybersecurity  incidents  could  disrupt  business  operations,  result  in  the  loss  of  critical  and  confidential  information,  and  adversely  impact  our
reputation and results of operations.

Global cybersecurity threats can range from uncoordinated individual attempts to gain unauthorized access to our information technology (IT) systems to
sophisticated  and  targeted  measures  known  as  advanced  persistent  threats.  While  we  employ  comprehensive  measures  to  prevent,  detect,  address  and
mitigate these threats (including access controls, insurance, vulnerability assessments, continuous monitoring of our IT networks and systems, maintenance
of backup and protective systems and user training and education), cybersecurity incidents, depending on their nature and scope, could potentially result in
the misappropriation, destruction, corruption or unavailability of critical data and confidential or proprietary information (our own or that of third parties)
and the disruption of business operations. The potential consequences of a material cybersecurity incident include reputational damage, loss of customers,
litigation with customers and other parties, loss of trade secrets and other proprietary business data and increased cybersecurity protection and remediation
costs, which in turn could adversely affect our competitiveness and results of operations.

Our business will suffer if our network systems fail or become unavailable.

A reduction in the performance, reliability and availability of our network infrastructure would harm our ability to distribute our solutions to our users, as
well as our reputation and ability to attract and retain customers. Our systems and operations could be damaged or interrupted by fire, flood, power loss,
telecommunications failure, Internet breakdown, earthquake and similar events. Our systems could also be subject to viruses, break-ins, sabotage, acts of
terrorism, acts of vandalism, hacking, cyber-terrorism and similar misconduct. We might not carry adequate business interruption insurance to compensate
us for losses that may occur from a system outage. Any system error or failure that causes interruption in availability of our solutions or an increase in
response time could result in a loss of potential customers, which could have a material adverse effect on our business, financial condition and results of
operations. If we suffer sustained or repeated interruptions, then our solutions and services could be less attractive to our users and our business would be
materially harmed.

12

 
 
 
 
 
 
 
 
 
 
Risks Relating to Our Common Stock

If a market for our common stock is not maintained, shareholders may be unable to sell their shares.

Our common stock is traded under the symbol “OPRX” on the Nasdaq Capital Market. We do not currently have a consistent active trading market. There
can be no assurance that a consistent active and liquid trading market will develop or, if developed, that it will be sustained.

Historically, our securities have been thinly traded. Accordingly, it may be difficult to sell shares of our common stock without significantly depressing the
value  of  the  stock.  Unless  we  are  successful  in  developing  continued  investor  interest  in  our  stock,  sales  of  our  stock  could  continue  to  result  in  major
fluctuations in the price of the stock.

The market price of our common stock is likely to be highly volatile and could fluctuate widely in price in response to various factors, many of which
are beyond our control.

Our stock price is subject to a number of factors, including:

● Technological innovations or new solutions and services by us or our competitors;

● Government regulation of our solutions and services;

● The establishment of partnerships with other healthcare companies;

● Intellectual property disputes;

● Additions or departures of key personnel;

● Sales of our common stock;

● Our ability to execute our business plan;

● Operating results below or exceeding expectations;

● Our operating and financial performance and prospects;

● Loss or addition of any strategic relationship;

● General financial, domestic, international, economic, industry and other market trends or conditions; and

● Period-to-period fluctuations in our financial results.

Our stock price may fluctuate widely as a result of any of the above. In addition, the securities markets have from time to time experienced significant price
and  volume  fluctuations  that  are  unrelated  to  the  operating  performance  of  particular  companies.  These  market  fluctuations  may  also  materially  and
adversely affect the market price of our common stock.

We do not expect to pay dividends in the foreseeable future and any return on investment may be limited to the value of our common stock.

We have never declared or paid any cash dividends on our common stock. We currently intend to retain all available funds and future earnings, if any, to
fund our future growth and do not expect to declare or pay any dividend on shares of our common stock in the foreseeable future. As a result, the success of
an  investment  in  our  common  stock  may  depend  entirely  upon  any  future  appreciation  in  its  value.  There  is  no  guarantee  that  our  common  stock  will
appreciate in value or even maintain the price at which it was purchased.

13

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
“Anti-takeover” provisions may make it more difficult for a third party to acquire control of us, even if the change in control would be beneficial
to shareholders.

The Company is a Nevada corporation. Anti-takeover provisions in Nevada law and our charter and bylaws could make it more difficult for a third party to
acquire control of us. These provisions could adversely affect the market price of the common stock and could reduce the amount that shareholders might
receive if the Company is sold. For example, our charter provides that the board of directors may issue preferred stock without shareholder approval. In
addition, our bylaws provide that shareholders cannot act by written consent and that directors may be removed by shareholders only with the approval of
the  holders  of  not  less  than  two-thirds  of  the  voting  power  of  the  issued  and  outstanding  stock  entitled  to  vote  at  an  annual  or  special  meeting  of  the
shareholders. 

Risks Related to Being a Public Company

A  material  weakness  in  our  internal  control  over  financial  reporting,  if  not  remediated,  could  result  in  material  misstatements  in  our  financial
statements. As  a  result,  current  and  potential  shareholders  and  customers  could  lose  confidence  in  our  financial  reporting,  which  could  harm  our
business, the trading price of our stock and our ability to retain our current customers or obtain new customers.

Management  is  responsible  for  establishing  and  maintaining  adequate  internal  control  over  financial  reporting,  as  defined  in  Rule  13a-15(f)  under  the
Securities Exchange Act of 1934, as amended. A material weakness (as defined in Rule 12b-2) is a deficiency, or combination of deficiencies, in internal
control over financial reporting, such that there is a reasonable possibility that a material misstatement of annual or interim financial statements will not be
prevented or detected on a timely basis. We have had material weaknesses in the past that were remediated as of December 31, 2020. We cannot provide
assurance that we will not in the future have additional material weaknesses in our internal control over financial reporting. As a result, we may be required
to implement further remedial measures and to design enhanced processes and controls to address deficiencies, which could result in significant costs to us
and  require  us  to  divert  substantial  resources,  including  management  time,  from  other  activities.  If  we  identify  material  weaknesses  or  fail  to  maintain
adequate internal controls over financial reporting in the future, we may not be able to prepare reliable financial reports and comply with our reporting
obligations under the Exchange Act on a timely basis. Any such delays in the preparation of financial reports and the filing of our periodic reports may
result  in  a  loss  of  public  confidence  in  the  reliability  of  our  financial  statements,  the  commencement  of  litigation,  or  the  commencement  of  regulatory
action against us, which may include court actions or administrative proceedings, any of which could materially adversely affect our business, the market
value of our securities and our access to the capital markets.

14

 
 
 
 
 
 
 
Item 1B. Unresolved Staff comments

None

Item 2. Properties

Currently, we do not own any real estate. Our principal executive offices are located at 400 Water Street, Suite 200, Rochester, Michigan 48307.  

As of December 31, 2021, we had operating leases with initial lease terms greater than 12 months for office space in three multitenant facilities. The lease
on our headquarters space in Rochester, Michigan expires November 30, 2023, with a two-year renewal option through 2025, with monthly rent payable at
rates  ranging  from  $6,384  to  $6,688.  We  have  assumed  renewal  of  this  lease  for  financial  statement  purposes.  We  also  had  a  lease  on  office  space  in
Cranbury, New Jersey, which expired in January 2022, with a monthly payment of $3,158, as well as a lease of approximately $1,883 per month in Zagreb,
Croatia expiring in 2024. We did not renew the New Jersey lease. We also lease minor amounts of space in shared space facilities on a month to month
basis as necessary.

Item 3. Legal Proceedings

We have no current legal proceedings.

Item 4. Mine Safety Disclosures

Not applicable.

Item 4.1 Information About Our Executive Officers

The following information sets forth the names, ages, and positions of our executive officers as of February 24, 2022.

Name
William J. Febbo
Stephen L. Silvestro
Marion Odence-Ford
Edward Stelmakh
Todd Inman

Age
53
44
57
56
66

Positions and Offices Held

  Chief Executive Officer
  Chief Commercial Officer
  General Counsel and Chief Compliance Officer
  Chief Financial Officer and Chief Operations Officer
  Chief Technology Officer

Set forth below is a brief description of the background and business experience of each of our current executive officers.

William J. Febbo

Mr. Febbo joined the Company as Chief Executive Officer and as a director in February 2016. Mr. Febbo founded Plexuus, LLC, a payment processing
business for medical professionals in September 2015 and remained its Chairman from September 2015 to December 2020. From April 2007 to September
2015, Mr. Febbo served as Chief Operating Officer of Merriman Holdings, Inc., an investment banking firm, where he assisted with capital raises in the
tech, biotech, cleantech, consumer and resources industries. Mr. Febbo was a co-founder of, and from September 2013 to September 2015 served as Chief
Executive Officer of, Digital Capital Network, Inc. a transaction platform for institutional and accredited investors. Mr Febbo was a co-founder of, and
from  January  1999  to  September  2015  was  Chief  Executive  Officer  of,  MedPanel,  LLC,  a  provider  of  market  intelligence  and  communications  for  the
pharmaceutical,  biomedical,  and  medical  device  industries.  Since  2017,  Mr.  Febbo  has  been  a  faculty  member  of  the  Massachusetts  Institute  of
Technology’s  linQ  program,  which  is  a  collaborative  initiative  focused  on  increasing  the  potential  of  innovative  research  to  benefit  society  and  the
economy. Mr. Febbo currently serves as a director of Modular Medical (NASDAQ: MODD), a development stage medical device company focused on the
design,  development  and  eventual  commercialization  of  an  innovative  insulin  pump.  In  addition,  Mr.  Febbo  has  been  a  board  member  of  the  United
Nations Association of Greater Boston, a resource for the citizens of Greater Boston on the broad agenda of critical global issues addressed by the UN and
its agencies, since 2004.

15

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
On January 29, 2018, FINRA accepted a Letter of Acceptance, Waiver and Consent (the “Consent”) submitted by William Febbo. Without admitting or
denying the findings, Mr. Febbo consented to the sanctions and to the entry of findings that he permitted Merriman Capital, Inc. to conduct a securities
business while below its net capital requirement. From August 2012 to October 2015, Mr. Febbo was the Financial and Operations Principal (FinOp) for a
registered  broker-dealer,  Merriman  Capital,  Inc.  (“Merriman”).  During  certain  months  while  Mr.  Febbo  was  FinOp,  FINRA  found  that  certain  of
Merriman’s net capital filings with FINRA were inaccurate because of the method by which Merriman calculated net capital and that, when corrected, it
was retroactively determined that Merriman had operated below its minimum net capital requirements. Mr. Febbo, as FinOp, signed certain of these reports
and was thus held responsible. Based on the Consent, in settlement, Mr. Febbo, who was then no longer registered with any broker-dealer, accepted a fine
of $5,000, a 10-business day suspension from acting as FinOp for any FINRA member and required to requalify by examination for the Series 27 license
before again acting in a FinOp capacity.

Stephen L. Silvestro

Mr. Silvestro joined the Company as Chief Commercial Officer on April 29, 2019. Mr. Silvestro was with CCH® Tagetik, a Wolters Kluwer company that
provides corporate performance management software solutions for planning, consolidation and reporting, as its Vice President and General Manager from
January 2018 until April 2019. From April 2017 to January 2018, Mr. Silvestro was with Prognos Health, Inc., a healthcare data and analytics company, as
its Chief Commercial Officer and, before that, from September 2007 to April 2017, he was with Decision Resources Group, a multi-national corporation
that provides high value global data solutions, analytics and consulting services to pharmaceutical, biotech, medical device, healthcare provider and payer,
and managed care companies, in various capacities with him last serving as Executive Vice President, Head of Global Sales.  

Marion Odence-Ford

Ms. Odence-Ford joined the Company as General Counsel & Chief Compliance Officer in February 2021. From April 2013 to June 2020, Ms. Odence-
Ford  was  Vice  President  &  Deputy  General  Counsel  at  Decision  Resources  Group,  a  multi-national  corporation  that  provides  high  value  global  data
solutions, analytics and consulting services to pharmaceutical, biotech, medical device, healthcare provider and payer, and managed care companies. From
November  2004  to  November  2012,  Ms.  Odence-Ford  was  Vice  President  &  Associate  General  Counsel  at  CRA  International,  Inc.  (dba  Charles  River
Associates),  a  global  consulting  firm  that  offers  economic,  financial,  and  strategic  expertise  to  major  law  firms,  corporations,  accounting  firms,  and
governments around the world. From May 2004 to November 2004, Ms. Odence-Ford was a member of the GTC Law Group, LLP, a law firm specializing
in the business affairs of companies in the high tech and biotech industries. Prior to joining the GTC Law Group, Ms. Odence-Ford worked on the legal
teams  of  Bank  of  America  Corporation/Fleet  Boston  Financial  Corporation  from  November  2002  to  May  2004,  and  Akamai  Technologies,  Inc.  from
October 1999 to November 2002. Ms. Odence-Ford began her legal career in private practice at Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, PC, where
she advised public and private companies on corporate matters.

Edward Stelmakh

Mr. Stelmakh joined the Company as Chief Financial Officer and Chief Operating Officer on October 11, 2021. He has served as Senior Vice President,
Chief Financial Officer and Chief Operating Officer of Otsuka America Pharmaceuticals Inc. (“Otsuka”), a US division of a Japanese global healthcare
enterprise, since April 2020. Previously, he held various positions at Otsuka including Senior Vice President and Chief Financial Officer (December 2017 –
March 2020) and Vice President and Chief Financial Officer (December 2015 – November 2017). Prior to joining Otsuka, from March 2010 to December
2015, Mr. Stelmakh worked at Covance, a division of LabCorp, Inc., as Vice President, Finance, Clinical Development and Commercialization Services.
Prior thereto, Mr. Stelmakh held a variety of positions of increasing responsibilities at Johnson & Johnson, Sanofi-Aventis, Organon/Schering-Plough and
Mylan.

Todd Inman

Mr.  Inman  joined  the  Company  on  January  1,  2019  as  Vice  President,  Technology  and  became  the  Company’s  Chief  Technology  Officer  in  November
2019. Prior to joining the Company, from May 2017 to December 2018, Mr. Inman was the Founder and Chief Technology Officer of Meghadata, LLC, a
master data management firm, and from July 2016 to December 2017, Mr. Inman was the Founder and Managing Partner of Data Solutions Partners, a data
intelligence  solutions  company.  From  January  2011  through  June  2016,  Mr.  Inman  was  Director  of  Data  Solutions  at  Change  HealthCare,  a  healthcare
technology and business solutions company, and from 2005 to 2011, Mr. Inman was the Director of Data Integration of Emdeon Business Services, LLC,
an information technology and services company. Prior to Emdeon, from 2001 to 2005, Mr. Inman was the Director of Clearinghouse Services at WebMD
Health Corp and, from 1996 to 2001, he was the Manager of Clearinghouse Operations at Professional Office Systems, a CareFirst subsidiary, providing
medical office electronic data interchange services.

16

 
 
 
 
  
 
 
 
 
 
 
PART II

Item 5. Market for Registrant’s Common Equity and Related Stockholder Matters and Issuer Purchases of Equity Securities

Our common stock is traded under the symbol “OPRX” on the Nasdaq Capital Market.  At February 24, 2022, there were approximately 400 shareholders
of record of our common stock.

We currently intend to retain future earnings for the operation of our business. We have never declared or paid cash dividends on our common stock, and
we do not anticipate paying any cash dividends in the foreseeable future. Any payment of future dividends will be at the discretion of our board of directors
and will depend upon, among other things, our earnings, financial condition, capital requirements, level of indebtedness, and other factors that our board of
directors deems relevant.

For the information regarding our equity compensation plans, see PART III, Item 12, “Security Ownership of Certain Beneficial Owners and Management
and Related Stockholder Matters.”

17

 
 
 
 
 
 
 
Item 6. Reserved

Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations

Overview

We are a digital health technology company enabling care-focused engagement between life sciences organizations, healthcare providers, and patients at
critical  junctures  throughout  the  patient  care  journey.  Connecting  over  60%  of  U.S.  healthcare  providers  and  millions  of  their  patients  through  an
intelligent technology platform embedded within a proprietary point-of-care network, OptimizeRx helps patients start and stay on their medications.

Historically,  our  revenue  was  generated  primarily  through  the  facilitation  of  financial  messages  to  health  care  providers  via  their  EHR  and  ePrescribe
systems  using  the  OptimizeRx  proprietary  network  to  solve  the  ever-increasing  communication  barriers  between  pharmaceutical  representatives  and
healthcare providers that have presented in the rapidly changing healthcare industry. Over time, as the demand for communication of an increasing variety
of  different  health  information  between  life  science  companies,  providers,  and  patients  continued  to  rise,  our  platform  has  expanded  to  encompass
additional  solutions  that  enable  healthcare  providers  to  access  information  for  patients  at  the  point  of  care.  These  solutions  include  brand  messaging,
therapeutic  support  messaging,  brand  support,  and  innovative  patient  engagement  services,  all  of  which  now  make  up  a  significant  portion  of  our  total
revenue.

Our strategic focus remains on growing our existing client base and generating greater and more consistent revenues in part through our continued shift in
our business model toward enterprise level engagements with recurring revenue streams, while also broadening our platform with innovative proprietary
solutions  such  as  our  TelaRep™  virtual  communication  solution  and  our  AI-powered  real-world  evidence  solution  which  uses  sophisticated  proprietary
algorithms to derive additional revenue from our existing network. In addition, we have continued to expand our team in preparation for future growth
aspirations,  which  may  be  supplemented  with  future  acquisitions  and  other  strategic  collaborations  and  investments.  Our  strategy  for  driving  revenue
growth is also expected to work in tandem with our efforts to increase margin and profitability using the aforementioned recurring revenue models that
have inherently higher margins.

As the business continues to grow, operating expenses are expected to increase much more slowly than revenue.

The  following  discussion  includes  an  analysis  and  comparison  of  the  Company’s  2021  and  2020  fiscal  year  results  of  operations,  liquidity  and  capital
resources, and critical accounting policies.

COVID-19 Business Update

The  COVID-19  pandemic  created  unprecedented  challenges  in  the  healthcare  industry  which  increased  the  demand  for  unique  solutions  ranging  from
access to accurate and timely information to increasing the accessibility of medications and care management. We also leveraged our digital platform to
provide telehealth capabilities for healthcare providers to adapt to COVID-19 restrictions.

At  the  beginning  of  the  pandemic,  we  transitioned  our  global  workforce  to  working  remotely  to  maintain  the  health  and  safety  of  our  employees.
Governments of cities, states, and countries globally imposed restrictions on travel and business operations, which curtailed various means of performing
business and marketing activities such as the attending of health IT conferences. We are conducting business with certain modifications to employee travel
and  employee  work  locations.  In  addition,  we  have  implemented  health  and  safety  policies  in  our  offices  to  enable  our  employees  to  safely  return  to
traditional working arrangements. We will continue to actively monitor the situation and may take further actions that alter our business operations as may
be required by federal, state or local authorities or that we determine are in the best interests of our employees, customers, and shareholders.

18

 
 
 
 
 
 
 
 
 
 
 
 
 
The COVID-19 pandemic did not have an adverse impact on our financial condition and results of operations in 2021, and we currently do not expect the
results of future operations and our near-and-long-term financial position and growth prospects to be negatively impacted by the pandemic given the nature
of the business and the increased demand for digital health solutions.

Information pertaining to risk factors as it relates to the COVID-19 pandemic can be found in Item 1A. Risk Factors.

Key Performance Indicators

We developed a number of key performance indicators, and intend to monitor these going forward, to evaluate our business, measure our performance,
identify trends affecting our business and make strategic decisions.

Average revenue per top 20 pharmaceutical manufacturer. Average revenue per top 20 pharmaceutical manufacturer is calculated by taking the total
revenue the company recognized through pharmaceutical manufacturers listed in Fierce Pharma’s “The top 20 pharma companies by 2020 revenue” over
the last twelve months, divided by the total number of the aforementioned pharmaceutical manufacturers that our solutions helped support over that time
period.  The  Company  uses  this  metric  to  monitor  its  progress  in  “landing  and  expanding”  with  key  customers  within  its  largest  customer  vertical  and
believe it also provides investors with a transparent way to chart our progress in penetrating this important customer segment. The increase in the average
in 2021 as compared to 2020 is primarily the result of our focus on signing larger and more comprehensive deals.

Average revenue per top 20 pharmaceutical manufacturer

Twelve Months Ended
December 31

2021
2,484,557    $

2020
1,945,650 

  $

Percent of top 20 pharmaceutical manufacturers that are customers. Percent of top 20 pharmaceutical manufacturers that are customers is calculated
by taking the number of revenue generating customers that are pharmaceutical manufacturers listed in Fierce Pharma’s “The top 20 pharma companies by
2020 revenue” over the last 12 months, which is then divided by 20—which is the number of pharmaceutical manufacturers included in the aforementioned
list. The Company uses this metric to monitor its progress in penetrating key customers within its largest customer vertical and believes it also provides
investors with a transparent way to chart our progress in penetrating this important customer segment. The increase from 2020 to 2021 reflects continued
penetration into this core customer base and reflects two new top 20 pharma customers in 2021.

Percent of top 20 pharmaceutical manufacturers that are customers

19

Twelve Months Ended
December 31

2021

2020

95%   

85%

 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
 
   
 
Percent  of  total  revenue  attributable  to  top  20  pharmaceutical  manufacturers.  Percent  of  total  revenue  attributable  to  top  20  pharmaceutical
manufacturers is calculated by taking the total revenue the company recognized through pharmaceutical manufacturers listed in Fierce Pharma’s “The top
20 pharma companies by 2020 revenue” over the last twelve months, divided by our consolidated revenue over the same period. The Company uses this
metric to monitor its progress in “landing and expanding” with key customers within its largest customer vertical and believes it also provides investors
with a transparent way to chart our progress in penetrating this important customer segment. Our revenue from this core group of customers grew slightly
faster than our overall revenue, enabling us to maintain a similar percentage of revenues from this group.

Percent of total revenue attributable to top 20 pharmaceutical manufacturers

Twelve Months Ended
December 31

2021

2020

77%   

76%

Net  revenue  retention.  Net  revenue  retention  is  a  comparison  of  revenue  generated  from  all  customers  in  the  previous  twelve-month  period  to  total
revenue generated from the same customers in the following twelve-month period (i.e., excludes new customer relationships for the most recent twelve-
month  period).  The  Company  uses  this  metric  to  monitor  its  ability  to  improve  its  penetration  with  existing  customers  and  believes  it  also  provides
investors with a metric to chart our ability to increase our year-over-year penetration and revenue with existing customers. The retention rate in 2020 was
increased as a result of unplanned disruption to the industry caused by the Covid-19 pandemic. Our customers shifted funds previously designated for in-
person events to digital marketing throughout 2020. By 2021, while the pandemic continued, there was less disruption and customers shifted some funds
back to traditional channels.

Net revenue retention

Twelve Months Ended
December 31

2021

2020

127%   

162%

Revenue per average full-time employee. We define revenue per average full-time employee as total revenue over the last twelve months divided by the
average number of employees over the last twelve months (i.e., the average between the number of FTEs at the end of the reported period and the number
of FTEs at the end of the same period of the prior year). The Company uses this metric to monitor the productivity of its workforce and its ability to scale
efficiently over time and believes the metric provides investors with a way to chart our productivity and scalability. Our revenue rate grew more quickly
than our increase in the number of employees, allowing us to achieve more productivity. We were able to do this by taking advantage of the expandable
technology infrastructure that we have built over the years.

Revenue per average full-time employee

20

Twelve Months Ended 
December 31

2021

2020

  $

729,674    $

614,378 

 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
   
 
 
Results of Operations for the Years Ended December 31, 2021 and 2020

Net Revenue

Our net revenue increased 42% to $61.3 million for the year ended December 31, 2021 from $43.3 million for the year ended December 31, 2020. This
increase  resulted  from  a  combination  of  factors,  including  the  shift  to  enterprise  contracts,  increased  pharmaceutical  brands,  an  increased  distribution
network, and growth in our messaging solutions. We expect continued revenue growth in 2022 as a result of the foundations laid in 2020 and 2021.

Because the pharmaceutical industry is dominated by large companies with multiple brands, our revenue is concentrated in a relatively small number of
companies.  We  have  approximately  50  pharmaceutical  companies  as  customers.  However,  we  had  only  one  and  three  customers  that  individually
represented more than 10% of our revenues in 2021 and 2020, respectively.

Cost of Revenues

Our total cost of revenues, composed primarily of revenue share expense paid to our network partners, increased in the year ended December 31, 2021
compared  to  the  year  ended  December  31,  2020  due  to  the  increase  in  revenues.  Our  cost  of  revenues  as  a  percentage  of  revenue  decreased  from
approximately 44% in the year ended December 31, 2020 to approximately 42% in the year ended December 31, 2021.

This decrease in our cost of revenues as a percentage of revenue resulted primarily from solution mix, specifically the increase in services we provide that
are not subject to revenue share.

Gross Margin

Our gross margin, which is the difference between our revenues and our cost of revenues, increased from 2020 to 2021 as a result of the increased revenue.
In addition, our gross margin percentage increased from 56% in 2020 to 58% in 2021 for the reasons discussed above in the cost of revenues section. We
expect our gross margins to be in the 57% to 60% range in 2022.

Operating Expenses

Operating  expenses  increased  to  $35.3  million  for  the  year  ended  December  31,  2021,  from  $26.2  million  for  the  year  ended  December  31,  2020,  an
increase of approximately 34%. The detail by major category is reflected in the table below. Certain 2020 expenses were reclassified in the table to be
comparable to the 2021 presentation.

Compensation Expense
Stock-based Compensation
Contractors and Consultants
Professional Fees
Board Compensation
Investor Relations
Advertising and Promotion
Depreciation and Amortization
Technology Infrastructure Costs
Data
Integration Incentives
Office, Facility and Other
Travel

Total Operating Expense

  $

Years Ended December 31

2021

2020

17,926,205    $
5,491,957     
1,763,906     
1,528,893     
245,000     
215,490     
1,029,208     
2,086,452     
1,149,855     
1,008,098     
1,425,274     
1,047,672     
359,104     

13,666,805 
3,172,840 
1,925,192 
1,312,395 
225,250 
132,652 
615,938 
2,075,888 
834,879 
246,242 
811,131 
893,787 
327,741 

  $

35,277,114    $

26,240,740 

The main drivers for the overall increase in operating expenses in 2021 was our focus on staffing and scaling our company to foster and be able to support
our planned growth.

Within the operating expenses, there were a variety of increases, the largest of which was in compensation expense as a result of additional staff added in
2020 and 2021, including related benefits. During 2021, we added to our staff in several key areas, including product development, sales, and IT, and the
addition  of  our  General  Counsel  and  Chief  Compliance  Officer,  and  Chief  Financial  Officer/  Chief  Operating  Officer.  During  2021  we  hired  27  net
additional employees. We expect our compensation expense to continue to increase in 2022, as a result of the full year impact of 2021 hires and new hires
in 2022.

21

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
   
     
 
   
   
   
   
   
   
   
   
   
   
   
   
 
   
      
  
 
 
 
Stock  based  compensation  increased  by  $2.3  million  from  $3.2  million  in  2020  to  $5.5  million  in  2021  primarily  because  of  more  employees  and  an
increase in our stock price. There is a relationship between the price of the stock at the time of either the option grant or the RSU grant and the fair value of
the option or RSU, resulting in a higher cost when the stock price is higher. Our stock price was higher, on average, in 2021 than 2020. In addition, we
hired 3 high level executives, which tend to have larger awards, and awarded the CEO a market-based grant with a requisite service period of less than 3
years.

Contractors and consultants decreased from 2020 to 2021 as we added staff to fill roles previously filled by consultants or contractors.

Professional fees increased by 16% in 2021 compared with 2020. With the assistance of an outside legal firm, we undertook a comprehensive governance
review of our bylaws, board charters, equity compensation plan, and overall corporate policies. The cost of this review, partially offset by a reduction in the
cost of our audit, accounts for the increase.

Board compensation increased slightly from 2020 to 2021 due to the full year impact of an increase in the size of our board in 2020. This represents only
the cash portion of the compensation.

Investor relations increased in 2021as a result of hiring a new investor relations firm, as well as increased activity in the area.

Our advertising and promotion costs increased from 2020 to 2021 as a result of a resumption in the sponsorship of, and attendance at, conferences. These
activities were drastically reduced in 2020 due to the global pandemic. These activities were increased in 2021 once a Covid vaccine was developed.

Technology infrastructure costs increased due to continued investment in our operating systems to facilitate new products as well as the implementation of
additional software products to increase efficiency and information dissemination.

Data costs increased as we have purchased more data, primarily to aid in our selling effort and allow customers to target their messages more appropriately
based on this data, thereby increasing our ability to charge premium prices for more highly targeted messages.

Integration and exclusivity costs, which represent payments to partners for access and/or exclusivity, increased because of new agreements signed. These
payments are usually made in lump sums and expensed over the term of the contracts. These expenses are an important part of our ability to expand our
network. These costs increased in 2021, as we signed more contracts and contracts with larger payments.

Depreciation and amortization in 2021 remained relatively similar to 2020. We expect depreciation and amortization expense in 2022 to increase from 2021
levels as we continue to invest in the growth of our business.

Office, facility, and other miscellaneous costs increased from 2020 to 2021. The main reason for the change related to a higher level of activity with more
employees, as well as hiring expenses, including recruiter fees.

Travel increased slightly from 2020 to 2021 as we reopened travel gradually in the second half of the year. In 2020, we had three months of normal travel
pre-pandemic followed by very little the remainder of the year, while 2021 had lower levels than normal spread more throughout the year.

Net Income (Loss)

We finished the year ended December 31, 2021 with net income of $0.4 million, as compared to a net loss of $2.2 million during the year ended December
31, 2020. The reasons for specific components are discussed above. Overall, we had an increase in revenue and gross margin partially offset by increased
operating expenses.. In addition, the income or loss in both periods included significant noncash items. We had $5.2 million in noncash operating expenses
in 2020 and $7.6 million in noncash operating expenses in 2021.

22

 
 
 
 
  
 
  
 
 
  
  
 
 
 
 
 
Quarterly Financial Information

Following is a table of our quarterly operating results for 2021 for information purposes.

Revenues

Cost of revenues

Gross Profit

Operating Expenses

First
Quarter

Second
Quarter

Third
Quarter

Fourth
Quarter

Total Year

  $

11,229,211    $

13,625,639    $

16,124,951    $

20,312,797     

61,292,598 

5,104,603     

5,580,964     

7,047,832     

7,920,985     

25,654,384 

6,124,608     

8,044,675     

9,077,119     

12,391,812     

35,638,214 

6,762,916     

7,704,536     

9,038,929     

11,770,733     

35,277,114 

Income (Loss) from Operations

(638,308)    

340,139     

38,190     

621,079     

361,100 

Other income (expense)

931     

11,961     

1,704     

2,383     

16,979 

Income (loss) before Taxes

(637,377)    

352,100     

39,894     

623,462     

378,079 

Income tax benefit

Net Income (Loss)

Earnings (loss) per share

Basic
Diluted

-     

-     

-     

-     

- 

(637,377)    

352,100     

39,894     

623,462     

378,079 

  $
  $

(0.04)   $
(0.04)   $

0.02    $
0.02    $

0.00    $
0.00    $

0.04    $
0.03    $

0.02 
0.02 

Sum  of  four  quarterly  per  share  amounts  does  not  equal  annual  total  due  to  rounding  and  the  mechanics  of  the  weighted  average  shares  outstanding
calculation.

23

 
 
 
 
 
 
   
   
   
   
 
 
   
     
     
     
     
 
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
      
      
      
      
  
 
 
Following is a table of our quarterly operating results for 2020 for information purposes.

Revenues

Cost of revenues

Gross Profit

Operating Expenses

First
Quarter

Second
Quarter

Third
Quarter

Fourth
Quarter

Total Year

  $

7,584,602    $

8,783,230    $

10,519,191    $

16,426,301    $

43,313,324 

3,241,763     

3,639,016     

4,504,844     

7,822,280     

19,207,903 

4,342,839     

5,144,214     

6,014,347     

8,604,021     

24,105,421 

6,602,091     

6,200,027     

6,191,069     

7,247,553     

26,240,740 

Income (Loss) from Operations

(2,259,252)    

(1,055,813)    

(176,722)    

1,356,468     

(2,135,319)

Other income (expense)

55,321     

(21,655)    

(106,172)    

698     

(71,808)

Income (loss) before Taxes

(2,203,931)    

(1,077,468)    

(282,894)    

1,357,166     

(2,207,127)

Income tax benefit

Net Income (Loss)

Earnings (loss) per share

Basic
Diluted

-     

-     

-     

-     

- 

(2,203,931)    

(1,077,468)    

(282,894)    

1,357,166     

(2,207,127)

  $
  $

(0.15)   $
(0.15)   $

(0.07)   $
(0.07)   $

(0.02)   $
(0.02)   $

0.09    $
0.08    $

(0.15)
(0.15)

Sum  of  four  quarterly  per  share  amounts  does  not  equal  annual  total  due  to  rounding  and  the  mechanics  of  the  weighted  average  shares  outstanding
calculation.

Liquidity and Capital Resources

As of December 31, 2021, we had total current assets of $115.1 million, compared with current liabilities of $9.4 million, resulting in working capital of
$105.7 million and a current ratio of 12 to 1. This compares with the working capital balance of $22.9 million and the current ratio of 3.3 to 1 at December
31, 2020. This increase in working capital, as discussed in more detail below, is primarily the result of a public offering of common stock in 2021.

Following is a table with summary data from the consolidated statement of cash flows for the years ended December 31, 2021 and 2020, as presented.

Net cash provided by (used in) operating activities
Net cash used in investing activities
Net cash provided by (used in) financing activities

Net increase in cash and cash equivalents

  $

2021

726,039    $
(485,999)    
73,924,954     

2020
(6,310,386)
(124,725)
(1,900,793)

  $

74,164,994    $

(8,335,904)

Our  operating  activities  provided  $0.7  million  in  the  year  ended  December  31,  2021,  as  compared  with  approximately  $6.3  million  used  in  operating
activities in the year ended December 31, 2020. The cash provided in 2021 was the result of our net income and non-cash expenses, which together totaled
$8.0 million. This was partially offset by the increased working capital, totaling $7.3 million, required to support higher revenues. The cash used in 2020
was primarily the result of the increased working capital required to support higher revenues, totaling $9.7 million. In addition, we had a net loss of $2.2
million,  but  non-cash  expenses  included  in  that  loss  of  $5.6  million,  resulting  in  net  cash  generated  of  $3.4  million  between  the  two,  which  offset  the
investment in working capital.

24

 
 
 
 
 
   
   
   
   
 
 
   
     
     
     
     
 
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
 
   
      
      
      
      
  
   
      
      
      
      
  
 
  
 
 
 
 
 
   
 
   
   
 
   
      
  
 
 
We used $0.5 million in investing activities in 2021, compared with $0.1 million in 2020, primarily as the result of purchase of both tangible and intangible
assets. The 2021 amount included $0.4 million of capitalized software development costs related to our proprietary systems and $0.1 million of tangible
property, primarily personal computers. The majority of the 2020 investments were in computers, with small additional amounts of capitalized software.

Financing activities provided $73.9 million in the year ended December 31, 2021. The cash provided in 2021 was the result of our underwritten offering in
2021,  which  generated  $70.7  million,  as  well  as  from  the  proceeds  of  option  exercises,  which  generated  $4.9  million.  This  was  partially  offset  by  the
payment of contingent consideration related to previous acquisitions of $1.6 million. We used cash of $1.9 million in 2020 as the result of the payment of
contingent consideration related to previous acquisitions of $4.4 million, partially offset by the proceeds from option exercises of $2.5 million.

We believe that funds generated from operations, together with existing cash, will be sufficient to finance our current operations and planned growth for the
next twelve months. We do not anticipate the need to raise any additional cash to support operations. However, we could require additional debt or equity
financing if we were to make any significant acquisitions for cash during that period. In addition, we believe we can generate the cash needed to operate
beyond the next 12 months from operations.

Off Balance Sheet Arrangements

As of December 31, 2021, there were no off-balance sheet arrangements.

Critical Accounting Policies

A “critical accounting policy” is one which is both important to the portrayal of a company’s financial condition and results, and requires management’s
most difficult, subjective, or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain.

Our accounting policies are discussed in detail in the footnotes to our financial statements included in this Annual Report on Form 10-K for the year ended
December 31, 2021; however, we consider our critical accounting policies to be those related to revenue recognition, calculation of revenue share expense
(cost of revenues), stock-based compensation, capitalization and related amortization of intangible assets and impairment of assets. Following is a summary
of those policies.

Revenue Recognition

Recognition of revenue requires evidence of a contract, probable collection of proceeds, and completion of substantially all performance obligations. We
use  a  5-step  model  to  recognize  revenue.  These  steps  are:  identify  the  contract  with  a  customer,  identify  the  performance  obligations  in  the  contract,
determine  the  transaction  price,  allocate  the  transaction  price  to  the  performance  obligations  in  the  contract,  and  recognize  revenue  when  or  as  the
performance obligations are satisfied.

Revenues are primarily generated from content delivery activities in which we deliver financial, clinical, or brand messaging through a distribution network
of eprescribers and electronic health record technology providers (channel partners), directly to consumers, or from reselling services that complement the
business. This content delivery for a customer is referred to as a program. Unless otherwise specified, revenue is recognized based on the selling price to
customers.

25

 
 
 
 
 
 
 
 
 
   
 
 
 
Our contracts are generally all less than one year and the primary performance obligation is delivery of messages or other forms of content, but the contract
may  contain  additional  services.  Additional  services  may  include  program  design,  which  is  the  design  of  the  content  delivery  program,  set  up,  and
reporting. We consider set up and reporting services to be complimentary to the primary performance obligation and recognized through performance of the
delivery of content. We consider the design of the programs and related consulting services to be performance obligations separate from the delivery of
messages.

As  the  content  is  distributed  through  the  platform  and  network  of  channel  partners  (a  transaction),  these  transactions  are  recorded,  and  revenue  is
recognized, over time as the distributions occur. Revenue for transactions can be realized based on a price per message, a price per redemption, as a flat fee
occurring  over  a  period  of  time,  or  upon  completion  of  the  program,  depending  on  the  client  contract.  We  recognize  setup  fees  that  are  required  for
integrating client offerings and campaigns into the rule-based content delivery system and network over the life of the initial program, based either on time,
or units delivered, depending upon which is most appropriate in the specific situation. Should a program be cancelled before completion, the balance of set
up  revenue  is  recognized  at  the  time  of  cancellation,  as  set  up  fees  are  nonrefundable.  Additionally,  we  also  recognize  revenue  for  providing  program
performance reporting and maintenance, either by our company directly delivering reports or by providing access to our online reporting portal that the
client can utilize. This reporting revenue is recognized over time as the messages are delivered. Program design, which is the design of the content delivery
program, and related consulting services are recognized as services are performed.

In some instances, we license certain of our software applications in arrangements that do not include other performance obligations. In those instances, we
record license revenue when the software is delivered for use to the license. In instances where our contracts included Software as a service, the revenue is
recognized over the subscription period as services are delivered to the customer.

In some instances, we also resell messaging solutions that are available through channel partners that are complementary to the core business and client
base.  These  partner  specific  solutions  are  frequently  similar  to  our  own  solutions  and  revenue  recognition  for  these  programs  is  the  same  as  described
above. In instances where we sell solutions on a commission basis, net revenue is recognized based on the commission-based revenue split that we receive.
There were no programs recorded on a net basis in the years presented. In instances where we resell these messaging solutions and have all financial risk
and significant operation input and risk, we record the revenue based on the gross amount sold and the amount paid to the channel partner as a cost of sales.

Cost of Revenues

The primary cost of revenue is revenue share expense. Based on the volume of transactions that are delivered through the channel partner network, we
provide a revenue share to compensate the partner for their promotion of the campaign. Revenue shares are a negotiated percentage of the transaction fees
and can also be specific to special considerations and campaigns. In addition, we pay revenue share to ConnectiveRx as a result of a 2014 legal settlement
in an amount equal to the greater of 10% of financial messaging distribution revenues generated through our integrated network, or $0.37 per financial
message distributed through our integrated network. As our solution mix has expanded and our revenues have grown, financial messaging has become a
smaller percentage of our revenues and these payments to ConnectiveRx, a smaller portion of our revenue share. The contractual amount due to the channel
partners is recorded as an expense at the time the message is distributed.

Intangible Assets

Intangible assets are stated at cost. Finite-lived assets are being amortized over their estimated useful lives of fifteen to seventeen years for patents, eight
years for customer relationships, fifteen years for tradenames, four years for covenants not to compete, and three to four years for software and websites, all
using the straight-line method. These assets are evaluated when there is a triggering event. There was no impairment of our intangible assets in either year
presented.

26

 
 
 
 
 
 
 
 
 
 
Goodwill

We evaluate goodwill for impairment during our fiscal fourth quarter, or more frequently if an event occurs or circumstances change. We determined there
was no impairment as goodwill had a fair value comfortably in excess of its carrying value.

Stock-based Compensation

We use the fair value method to account for stock-based compensation. The fair value of the equity instrument is charged directly to compensation expense
and additional paid-in capital over the period during which services are rendered. The fair value of each award is estimated on the date of each grant.

For options, fair value is estimated using the Black-Scholes option pricing model that uses the following assumptions. Estimated volatilities are based on
the historical volatility of our stock over the same period as the expected term of the options. The expected term of options granted represents the period of
time that options granted are expected to be outstanding. We use historical data to estimate option exercise behavior and to determine this term. The risk-
free rate used is based on the U.S. Treasury yield curve in effect at the time of the grant using a time period equal to the expected option term. We have
never paid dividends and do not expect to pay any dividends in the future.

The Black-Scholes option valuation model and other existing models were developed for use in estimating the fair value of traded options that have no
vesting  restrictions  and  are  fully  transferable.  These  option  valuation  models  require  the  input  of,  and  are  highly  sensitive  to,  subjective  assumptions
including the expected stock price volatility. Our stock options have characteristics significantly different from those of traded options, and changes in the
subjective input assumptions could materially affect the fair value estimate.

For restricted stock units, the fair value is based on the market value of the Company’s common stock on the date of grant. For market based restricted
stock units, fair value is estimated using a Monte Carlo simulation model. This valuation technique includes estimating the movement of stock prices and
the effects of volatility, interest rates and dividends.

Recently Issued Accounting Pronouncements

In  December  2019,  the  FASB  issued  ASU  No.  2019-12,  Income  Taxes  (Topic  740):  Simplifying  the  Accounting  for  Income  Taxes.  ASU  2019-12  is
intended to improve consistent application and simplify the accounting for income taxes. ASU 2019-12 removes certain exceptions to the general principles
in Topic 740 and clarifies and amends existing guidance. ASU 2019-12 was effective for us as of January 1, 2021. The adoption of this standard did not
have a material effect on our financial position, results of operations, or cash flows.

Not Yet Adopted

ASU Topic 2021-08 Business Combinations (Topic 805), Accounting for Contract Assets and Contract Liabilities from Contracts with Customers, which
requires contract assets and contract liabilities acquired in a business combination to be recognized and measured by the acquirer on the acquisition date in
accordance with ASC 606, Revenue from Contracts with Customers, as if it had originated the contracts. The standard is effective for the Company's fiscal
year beginning January 1, 2023, with early adoption permitted. The Company is currently evaluating the effect of this pronouncement on its Consolidated
Financial Statements, but it is not expected to have a material impact.

Item 7A. Quantitative and Qualitative Disclosures About Market Risk

Not applicable. 

27

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Item 8. Financial Statements and Supplementary Data

Index to Financial Statements Required by Article 8 of Regulation S-X:

Audited Financial Statements:

F-1
F-3
F-4
F-5
F-6
F-7
F-8

Reports of Independent Registered Public Accounting Firm;
Consolidated Balance Sheets as of December 31, 2021 and 2020;
Consolidated Statements of Operations for the years ended December 31, 2021 and 2020;
Consolidated Statement of Stockholders’ Equity for the year ended December 31, 2021;
Consolidated Statement of Stockholders’ Equity for the year ended December 31, 2020;
Consolidated Statements of Cash Flows for the years ended December 31, 2021 and 2020; and
Notes to Consolidated Financial Statements

28

 
 
 
 
 
 
Report of Independent Registered Public Accounting Firm

To the Shareholders and Board of Directors of
OptimizeRx Corporation

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of OptimizeRx Corporation and Subsidiaries (the Company) as of December 31, 2021 and
2020, and the related consolidated statements of operations, stockholders’ equity and cash flows for the years then ended, and the related notes (collectively
referred to as the consolidated financial statements). We have also audited the Company’s internal control over financial reporting as December 31, 2021,
based on criteria established in Internal Control – Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway
Commission (COSO).

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the financial position of the Company as of
December  31,  2021  and  2020,  and  the  results  of  its  operations  and  its  cash  flows  for  the  years  then  ended,  in  conformity  with  accounting  principles
generally accepted in the United States of America. Also, in our opinion, the Company maintained, in all material respects, effective internal control over
financial reporting as of December 31, 2021, based on criteria established in Internal Control – Integrated Framework (2013) issued by COSO.

Basis for Opinion

The  Company’s  management  is  responsible  for  these  financial  statements,  for  maintaining  effective  internal  control  over  financial  reporting,  and  for  its
assessment  of  the  effectiveness  of  internal  control  over  financial  reporting  included  in  the  accompanying  Report  on  Internal  Control  over  Financial
Reporting.  Our  responsibility  is  to  express  an  opinion  on  the  Company’s  consolidated  financial  statements  and  an  opinion  on  the  Company’s  internal
control over financial reporting based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board
(United  States)  (PCAOB)  and  are  required  to  be  independent  with  respect  to  the  Company  in  accordance  with  the  U.S.  federal  securities  laws  and  the
applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable
assurance  about  whether  the  consolidated  financial  statements  are  free  of  material  misstatement,  whether  due  to  error  or  fraud,  and  whether  effective
internal control over financial reporting was maintained in all material respects.

Our audits of the financial statements included performing procedures to assess the risks of material misstatement of the consolidated financial statements,
whether  due  to  error  or  fraud,  and  performing  procedures  that  respond  to  those  risks.  Such  procedures  include  examining,  on  a  test  basis,  evidence
regarding  the  amounts  and  disclosures  in  the  consolidated  financial  statements.  Our  audits  also  included  evaluating  the  accounting  principles  used  and
significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audit
provides a reasonable basis for our opinion. Our audit of internal control over financial reporting included obtaining an understanding of internal control
over financial reporting, assessing the risk that a material weakness exists, and testing and evaluating the design and operating effectiveness of internal
control based on the assessed risk. Our audits also included performing such other procedures as we considered necessary in the circumstances. We believe
that our audits provide a reasonable basis for our opinions.

F-1

 
 
 
 
 
 
 
 
 
 
 
 
 
Definition and Limitations of Internal Control over Financial Reporting

A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting
and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control
over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly
reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit
preparation  of  financial  statements  in  accordance  with  generally  accepted  accounting  principles,  and  that  receipts  and  expenditures  of  the  company  are
being  made  only  in  accordance  with  authorizations  of  management  and  directors  of  the  company;  and  (3)  provide  reasonable  assurance  regarding
prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial
statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of
effectiveness  to  future  periods  are  subject  to  the  risk  that  controls  may  become  inadequate  because  of  changes  in  conditions,  or  that  the  degree  of
compliance with the policies or procedures may deteriorate.

Critical Audit Matter

The  critical  audit  matter  communicated  below  is  a  matter  arising  from  the  current  period  audit  of  the  consolidated  financial  statements  that  were
communicated or required to be communicated to the audit committee and that: (1) relate to accounts or disclosures that are material to the consolidated
financial statements and (2) involved especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter
in  any  way  our  opinion  on  the  consolidated  financial  statements,  taken  as  a  whole,  and  we  are  not,  by  communicating  the  critical  audit  matter  below,
providing separate opinions on the critical audit matter or on the accounts or disclosures to which they related.

Critical Audit Matter - Revenue Recognition

As disclosed in Note 2 to the consolidated financial statements, the Company recognizes revenue upon transfer of control of promised products or services
to customers in an amount that reflects the consideration the Company expects to receive in exchange for those products or services.

Significant  judgment  is  exercised  by  the  Company  in  determining  revenue  recognition  for  these  customer  agreements  and  includes  the  following:  (1)
determining whether services are considered distinct performance obligations that should be accounted for separately versus together (2) the pattern and
timing of delivery for each distinct performance obligation, and (3) identification and treatment of contract terms that may impact the timing and amount of
revenue recognized.

How the Critical Audit Matter Was Addressed in the Audit

The audit procedures we performed to address this critical audit matter included the following: (1) obtaining an understanding of the design and operating
effectiveness  of  controls  related  to  identifying  distinct  performance  obligations,  determining  the  timing  of  revenue  recognition  and  any  estimation  of
variable  consideration,  (2)  selection  of  a  sample  of  customer  agreements  and  testing  management’s  identification  and  treatment  of  contract  terms,  and
testing the mathematical accuracy of management’s calculations of revenue and the associated timing of revenue recognized in the consolidated financial
statements.

We have served as the Company’s auditor since 2020.

/s/ UHY LLP

Sterling Heights, Michigan
February 28, 2022

F-2

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
OPTIMIZERx CORPORATION
Consolidated Balance Sheets

ASSETS

Current Assets

Cash and cash equivalents
Accounts receivable, net
Prepaid expenses
Total Current Assets
Property and equipment, net
Other Assets
Goodwill
Technology assets, net
Patent rights, net
Right of use assets, net
Other intangible assets, net
Security deposits and other assets

Total Other Assets
TOTAL ASSETS

LIABILITIES AND STOCKHOLDERS’ EQUITY

Current Liabilities

Accounts payable – trade
Accrued expenses
Revenue share payable
Current portion of lease liabilities
Contingent purchase price payable
Deferred revenue
Total Current Liabilities

Non-current Liabilities

Lease liabilities, net of current portion

Total Liabilities
Commitments and contingencies (See Note 14)
Stockholders’ Equity

Preferred stock, $0.001 par value, 10,000,000 shares authorized, none issued and outstanding at December 31, 2021

and 2020,

Common stock, $0.001 par value, 166,666,667 shares authorized, 17,860,975 and 15,223,340 shares issued and

outstanding at December 31, 2021 and 2020, respectively

Additional paid-in-capital
Accumulated deficit

Total Stockholders’ Equity
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY

The accompanying notes are an integral part of these financial statements. 

F-3

December 31, 
2021

December 31, 
2020

  $

84,681,770    $
24,800,585     
5,630,655     
115,113,010     
143,818     

10,516,776 
17,885,705 
4,456,611 
32,859,092 
148,854 

14,740,031     
4,589,126     
2,155,026     
328,820     
3,902,502     
12,859     
25,728,364     
  $ 140,985,192    $

14,740,031 
5,251,822 
2,349,570 
445,974 
4,519,552 
12,859 
27,319,808 
60,327,754 

  $

606,808    $
2,902,836     
4,378,216     
90,982     
-     
1,389,907     
9,368,749     

618,250 
2,420,361 
4,969,868 
123,220 
1,610,813 
285,795 
10,028,307 

236,726     
9,605,475     

325,533 
10,353,840 

-     

- 

17,861     
166,615,514     
(35,253,658)    
131,379,717     
  $ 140,985,192    $

15,223 
85,590,428 
(35,631,737)
49,973,914 
60,327,754 

 
 
 
 
 
   
 
 
    
  
 
 
    
  
 
    
  
   
   
   
   
   
      
  
   
   
   
   
   
   
   
 
   
      
  
   
      
  
 
   
      
  
   
      
  
   
   
   
   
   
   
   
      
  
   
   
   
      
  
   
      
  
   
   
   
   
   
 
 
OPTIMIZERx CORPORATION
Consolidated Statements of Operations

Revenue
Cost of revenues
Gross margin

Operating Expenses

Stock-based compensation
Depreciation, amortization, and noncash lease expense
Other general and administrative expenses

Total operating expenses
Income (loss) from operations
Other income (expense)
Interest income
Change in fair value of contingent consideration

Total other income (expense)
Income (loss) before provision for income taxes
Income tax benefit
Net income (loss)

Weighted average number of shares outstanding – basic

Weighted average number of shares outstanding – diluted

Income (loss) per share – basic

Income (loss) per share – diluted

The accompanying notes are an integral part of these financial statements.

F-4

For the 
year ended 
December 31,
2021

For the 
year ended 
December 31,
2020

  $

61,292,598    $
25,654,384     
35,638,214     

43,313,323 
19,207,902 
24,105,421 

5,491,957     
2,086,454     
27,698,703     
35,277,114     
361,100     

16,979     
-     
16,979     
378,079     
-     
378,079    $
17,228,019     
17,690,489     
0.02    $
0.02    $

3,172,840 
2,075,888 
20,992,012 
26,240,740 
(2,135,319)

68,582 
(140,390)
(71,808)
(2,207,127)
- 
(2,207,127)
14,827,923 
14,827,923 
(0.15)
(0.15)

  $

  $
  $

 
 
 
 
 
   
 
 
 
    
  
   
   
 
   
      
  
   
      
  
   
   
   
   
   
   
      
  
   
   
   
   
   
   
   
 
 
OPTIMIZERx CORPORATION
Consolidated Statement of Stockholders’ Equity for the Year
Ended December 31, 2021

Balance, January 1, 2021
Stock-based compensation expense

Options
Restricted Stock

Issuance of common stock:
For board compensation
For stock options exercised
Public offering of common shares, net of offering costs

Net income for the year
Balance, December 31, 2021

Common
Stock 
Shares

Common
Stock 
Amount

Additional
Paid-in 
Capital

Accumulated 
Deficit

Total
Stockholders’ 
Equity

15,223,340    $

15,223    $

85,590,428    $ (35,631,737)   $

49,973,914 

-     
3,333     

-     
3     

2,709,781     
2,532,088     

-     
-     

2,709,781 
2,532,091 

4,730     
1,105,822     
1,523,750     
-     
17,860,975    $

5     
1,106     
1,524     
-     

250,085 
4,864,231 
70,671,536 
378,079 
17,861    $ 166,615,514    $ (35,253,658)   $ 131,379,717 

250,080     
4,863,125     
70,670,012     
-     

-     
-     
-     
378,079     

The accompanying notes are an integral part of these financial statements.

F-5

 
 
 
 
 
   
   
   
   
 
 
 
    
    
    
    
  
   
   
      
      
      
      
  
   
   
   
      
      
      
      
  
   
   
   
   
   
 
 
OPTIMIZERx CORPORATION
Consolidated Statement of Stockholders’ Equity for the Year
Ended December 31, 2020

Balance, January 1, 2020
Stock-based compensation expense

Options
Restricted Stock

Issuance of common stock:
For board compensation
For stock options exercised
For contingent purchase price and escrow hold back

Net loss for the year
Balance, December 31, 2020

Common
Stock 
Shares

Common
Stock 
Amount

Additional
Paid-in 
Capital

Accumulated 
Deficit

Total
Stockholders’ 
Equity

14,600,579    $

14,601    $

78,272,268    $ (33,424,610)   $

44,862,259 

-     
84,746     

-     
84     

1,884,202     
838,430     

-     
-     

1,884,202 
838,514 

28,809     
414,705     
94,501     
-     
15,223,340    $

29     
415     
94     
-     
15,223    $

450,095     
2,487,979     
1,657,454     

-     
-     
-     
(2,207,127)    
85,590,428    $ (35,631,737)   $

450,124 
2,488,394 
1,657,548 
(2,207,127)
49,973,914 

The accompanying notes are an integral part of these financial statements.

F-6

 
 
 
 
 
   
   
   
   
 
 
 
    
    
    
    
  
   
   
      
      
      
      
  
   
   
   
      
      
      
      
  
   
   
   
   
      
   
 
 
OPTIMIZERx CORPORATION
Consolidated Statements of Cash Flows

CASH FLOWS FROM OPERATING ACTIVITIES:

Net income (loss)

Adjustments to reconcile net income (loss) to net cash used in operating activities:

Depreciation and amortization
Noncash lease expense
Increase in bad debt reserve
Stock-based compensation
Change in fair value of contingent consideration

Changes in:

Accounts receivable
Prepaid expenses and other assets
Accounts payable
Revenue share payable
Accrued expenses and other
Change in operating lease liabilities
Deferred revenue

NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES
CASH FLOWS FROM INVESTING ACTIVITIES:

Purchases of property and equipment
Acquisition of intangible assets, including intellectual property rights
Capitalized software development costs

NET CASH USED IN INVESTING ACTIVITIES
CASH FLOWS FROM FINANCING ACTIVITIES:

Proceeds from issuance of common stock, net of offering costs
Proceeds from exercise of stock options
Payment of contingent consideration

NET CASH PROVIDED BY (USED IN) FINANCING ACTIVITIES
NET INCREASE (DECREASE IN) CASH AND CASH EQUIVALENTS
CASH AND CASH EQUIVALENTS – BEGINNING OF PERIOD
CASH AND CASH EQUIVALENTS – END OF PERIOD

SUPPLEMENTAL CASH FLOW INFORMATION:

Cash paid for interest

Cash paid for income taxes

NON-CASH INVESTING AND FINANCING ACTIVITIES:

Acquisition liabilities paid in stock

For the 
year ended 
December 31,
2021

For the 
year ended 
December 31, 
2020

  $

378,079    $

(2,207,127)

1,965,325     
121,129     
80,000     
5,491,957     
-     

(6,994,880)    
(1,174,044)    
(11,442)    
(591,652)    
482,475     
(125,020)    
1,104,112     
726,039     

1,971,083 
104,805 
200,000 
3,172,840 
140,390 

(10,667,680)
(3,517,700)
125,255 
3,351,430 
1,416,884 
(106,347)
(294,219)
(6,310,386)

(100,322)    
(21,511)    
(364,166)    
(485,999)    

(68,041)
(11,932)
(44,752)
(124,725)

70,671,536     
4,864,231     
(1,610,813)    
73,924,954     
74,164,994     
10,516,776     
84,681,770    $

- 
2,488,394 
(4,389,187)
(1,900,793)
(8,335,904)
18,852,680 
10,516,776 

-    $
-    $

- 
- 

-    $

1,657,548 

  $

  $
  $

  $

The accompanying notes are an integral part of these financial statements. 

F-7

 
 
 
 
 
   
 
 
    
  
   
      
  
   
   
   
   
   
   
      
  
   
   
   
   
   
   
   
   
   
      
  
   
   
   
   
   
      
  
   
   
   
   
   
   
   
      
  
   
      
  
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 1 – ORGANIZATION AND NATURE OF BUSINESS

OptimizeRx  is  a  digital  health  technology  company  enabling  care-focused  engagement  between  life  sciences  organizations,  healthcare  providers,  and
patients at critical junctures throughout the patient care journey. Connecting over 60% of U.S. healthcare providers and millions of their patients through an
intelligent technology platform embedded within a proprietary point-of-care network, OptimizeRx helps patients start and stay on their medications. 

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation
The financial statements of the Company have been prepared in accordance with generally accepted accounting principles in the United States of America
and are presented in US dollars.

Use of Estimates
The  preparation  of  financial  statements  in  conformity  with  generally  accepted  accounting  principles  requires  management  to  make  estimates  and
assumptions  that  affect  the  reported  amounts  of  assets  and  liabilities  at  the  date  of  the  financial  statements  and  the  reported  amounts  of  revenues  and
expenses during the reporting period. Estimates and assumptions have been made in determining the carrying value of assets, depreciable and amortizable
lives of tangible and intangible assets, the carrying value of liabilities, the valuation allowance for the deferred tax asset, the timing of revenue recognition
and related revenue share expenses, and inputs used in the calculation of stock based compensation. Actual results could differ from these estimates.

Principles of Consolidation
The financial statements reflect the consolidated results of OptimizeRx Corporation, a Nevada corporation, and its wholly owned subsidiaries: OptimizeRx
Corporation, a Michigan corporation, RMDY Health, Inc., a Delaware corporation, CareSpeak Communications, Inc., a New Jersey corporation, Cyberdiet,
a controlled foreign corporation incorporated in Israel, and CareSpeak Communications D.O.O., a Controlled Foreign Corporation incorporated in Croatia.
Together, these companies are referred to as “OptimizeRx” and “the Company.” All material intercompany transactions have been eliminated.

Reclassifications
Certain items in the previous year financial statements have been reclassified to match the current year presentation.

Foreign Currency

The Company’s functional currency is the U.S. dollar, however it pays certain expenses related to its two foreign subsidiaries in the local currency,
which is the sheckel for its subsidiary in Israel and the kuna for its Croatian subsidiary. All transactions are recorded at the exchange rate at the time of
payment. If there is a time lag between the time of recording the liability and the time of payment, a gain or loss is recorded in the Consolidated Statement
of Operations due to any fluctuations in the exchange rate.

Cash and Cash Equivalents
For purposes of the accompanying financial statements, the Company considers all highly liquid instruments, consisting of money market accounts, with an
initial maturity of three months or less to be cash equivalents.

Fair Value of Financial Instruments
Fair value is defined as the price that would be received upon sale of an asset or paid upon transfer of a liability in an orderly transaction between market
participants at the measurement date and in the principal or most advantageous market for that asset or liability. The fair value should be calculated based
on assumptions that market participants would use in pricing the asset or liability, not on assumptions specific to the entity. In addition, the fair value of
liabilities should include consideration of non-performance risk including our own credit risk.

F-8

 
  
 
 
 
 
 
 
 
 
 
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

In addition to defining fair value, the disclosure requirements around fair value establish a fair value hierarchy for valuation inputs, which is expanded. The
hierarchy prioritizes the inputs into three levels based on the extent to which inputs used in measuring fair value are observable in the market. Each fair
value measurement is reported in one of the three levels, which is determined by the lowest level input that is significant to the fair value measurement in
its entirety. These levels are:

Level 1 – Inputs are based upon unadjusted quoted prices for identical instruments traded in active markets.

Level 2 – Inputs are based upon significant observable inputs other than quoted prices included in Level 1, such as quoted prices for identical or similar
instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market or can
be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3 – Inputs are generally unobservable and typically reflect management’s estimates of assumptions that market participants would use in pricing the
asset or liability. The fair values are therefore determined using model-based techniques that include option pricing models, discounted cash flow models,
and similar techniques. The Company’s stock options and warrants are valued using level 3 inputs.

The  following  tables  present  the  fair  values  and  carrying  values  of  the  Company’s  financial  assets  and  liabilities  measured  on  a  recurring  basis  as  of
December 31, 2021 and 2020 and the valuation techniques used by the Company to determine those fair values.

Level 1

Level 2

2021
Level 3

Fair Value

    Carrying Value 

Liabilities
Contingent Purchase Price Payable

  $

-    $

-    $

-    $

-    $

- 

Level 1

Level 2

2020
Level 3

Fair Value

    Carrying Value 

Liabilities
Contingent Purchase Price Payable (1)

  $

-    $

-    $

1,610,813    $

1,610,813    $

1,610,813 

(1) The  contingent  consideration  is  based  off  achieving  certain  revenue  milestones  in  each  of  the  next  two  years.  The  Geometric-Brownian  motion
analysis was used to generate spot prices for use in an option pricing model. For 2020, the final payout had been determined and was paid in 2021.

F-9

 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
   
   
 
   
                   
     
     
     
              
   
      
                    
                       
                      
                  
 
  
 
 
 
 
 
   
   
   
 
 
    
    
    
    
  
   
      
      
      
      
  
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

The following table provides a summary of changes in fair value of the Company’s Level 3 financial instruments for the years ended December 31, 2021
and 2020.

Balance December 31, 2019
Payment of CareSpeak Communication contingent consideration
Payment of RMDY Health, Inc. contingent consideration
Increase in the value of the RMDY Health, Inc. contingent consideration
Balance December 31, 2020
Payment of CareSpeak Communication contingent consideration
Balance December 31, 2021

Amount

6,720,000 
(1,389,187)
(3,860,390)
140,390 
1,610,813 
(1,610,813)
- 

  $

  $

Accounts Receivable and Allowance for Doubtful Accounts
Accounts  receivable  are  reported  at  realizable  value,  net  of  allowances  for  doubtful  accounts,  which  is  estimated  and  recorded  in  the  period  the  related
revenue is recorded. The Company has a standardized approach to estimate and review the collectability of its receivables based on a number of factors,
including  the  period  they  have  been  outstanding.  Historical  collection  and  payer  reimbursement  experience  is  an  integral  part  of  the  estimation  process
related to allowances for doubtful accounts. In addition, the Company regularly assesses the state of its billing operations in order to identify issues, which
may impact the collectability of these receivables or reserve estimates. Because the Company’s customers are primarily large well-capitalized companies,
historically there has been very little bad debt expense. Bad debt expense was $80,000 for the year ended December 31, 2021 and $200,000 for the year
ended December 31, 2020. The allowance for doubtful accounts was $241,219 and $158,163 as of December 31, 2021 and 2020, respectively. From time to
time,  we  may  record  revenue  based  on  our  revenue  recognition  policies  described  below  in  advance  of  being  able  to  invoice  the  customer.  Included  in
accounts receivable are unbilled amounts of $2,110,865 and $757,218 at December 31, 2021, and December 31, 2020, respectively.

Property and Equipment
Property and equipment are stated at cost and are being depreciated over their estimated useful lives of three to five years for office equipment and three
years for computer equipment using the straight-line method of depreciation for book purposes. Maintenance and repair charges are expensed as incurred.

Intangible Assets
Intangible assets are stated at cost. Finite-lived assets are being amortized over their estimated useful lives of fifteen to seventeen years for patents, eight
years for customer relationships, fifteen years for tradenames, four years for covenants not to compete, and three to four years for software and websites, all
using the straight-line method. These assets are evaluated when there is a triggering event. There was no impairment of our intangible assets in either year
presented.

Goodwill
We  evaluate  goodwill  for  impairment  during  our  fiscal  fourth  quarter,  or  more  frequently  if  an  event  occurs  or  circumstances  change.  Our  analysis
determined that there was no impairment of our goodwill.

F-10

 
 
 
 
 
 
 
 
   
   
   
   
   
 
 
 
 
  
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

Revenue Recognition
Recognition of revenue requires evidence of a contract, probable collection of proceeds, and completion of substantially all performance obligations. We
use  a  5-step  model  to  recognize  revenue.  These  steps  are:  identify  the  contract  with  a  customer,  identify  the  performance  obligations  in  the  contract,
determine  the  transaction  price,  allocate  the  transaction  price  to  the  performance  obligations  in  the  contract,  and  recognize  revenue  when  or  as  the
performance obligations are satisfied.

Revenues  are  primarily  generated  from  content  delivery  activities  in  which  the  Company  delivers  financial,  clinical,  or  brand  messaging  through  a
distribution network of eprescribers and electronic health record technology providers (channel partners), directly to consumers, or from reselling services
that complement the business. This content delivery for a customer is referred to as a program. Unless otherwise specified, revenue is recognized based on
the selling price to customers.

The Company’s contracts are generally all less than one year and the primary performance obligation is delivery of messages, or content, but the contract
may  contain  additional  services.  Additional  services  may  include  program  design,  which  is  the  design  of  the  content  delivery  program,  set  up,  and
reporting. We consider set up and reporting services to be complimentary to the primary performance obligation and recognized through performance of the
delivery of content. We consider program design and related consulting services to be performance obligations separate from the delivery of messages.

As  the  content  is  distributed  through  the  platform  and  network  of  channel  partners  (a  transaction),  these  transactions  are  recorded,  and  revenue  is
recognized, over time as the distributions occur. Revenue for transactions can be realized based on a price per message, a price per redemption, as a flat fee
occurring over a period of time, or upon completion of the program, depending on the client contract. The Company recognizes setup fees that are required
for integrating client offerings and campaigns into the rule-based content delivery system and network over the life of the initial program, based either on
time, or units delivered, depending upon which is most appropriate in the specific situation. Should a program be cancelled before completion, the balance
of  set  up  revenue  is  recognized  at  the  time  of  cancellation,  as  set  up  fees  are  nonrefundable.  Additionally,  the  Company  also  recognizes  revenue  for
providing program performance reporting and maintenance, either by the Company directly delivering reports or by providing access to its online reporting
portal that the client can utilize. This reporting revenue is recognized over time as the messages are delivered. Program design, which is the design of the
content delivery program, and related consulting services are recognized as services are performed.

The majority of our revenue is earned from life sciences companies, such as pharmaceutical and biotech companies, or medical device makers. A small
portion of our revenue is earned from other sources, such as associations and technology companies. A break down is set forth in the table below.

Life Science Companies
Other
Total Revenue

2021
59,018,033    $
2,274,565     
61,292,598    $

2020
41,358,746 
1,954,577 
43,313,323 

  $

  $

F-11

 
  
 
 
 
 
 
 
 
 
 
   
 
   
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

Revenues (cont.)
In some instances, we license certain of our software applications in arrangements that do not include other performance obligations. In those instances, we
record license revenue when the software is delivered for use to the license. In instances where our contracts included Software as a service, the revenue is
recognized over the subscription period as services are delivered to the customer.

In some instances, the Company also resells messaging solutions that are available through channel partners that are complementary to the core business
and  client  base.  These  partner  specific  solutions  are  frequently  similar  to  our  own  solutions  and  revenue  recognition  for  these  programs  is  the  same  as
described above. In instances where the Company sells solutions on a commission basis, net revenue is recognized based on the commission-based revenue
split  that  the  Company  receives.  There  were  no  programs  recorded  on  a  net  basis  in  the  years  presented.  In  instances  where  the  Company  resells  these
messaging solutions and has all financial risk and significant operation input and risk, the Company records the revenue based on the gross amount sold
and the amount paid to the channel partner as a cost of sales.

Cost of Revenues
The primary cost of revenue is revenue share expense. Based on the volume of transactions that are delivered through the channel partner network, the
Company provides a revenue share to compensate the partner, or others, for their promotion of the campaign. Revenue shares are a negotiated percentage
of the transaction fees and can also be specific to special considerations and campaigns. 

Income Taxes
Income  taxes  are  computed  using  the  asset  and  liability  method.  Under  the  asset  and  liability  method,  deferred  income  tax  assets  and  liabilities  are
determined based on the differences between the financial reporting and tax basis of assets and liabilities and are measured using the currently enacted tax
rates and laws. A valuation allowance is provided for the amount of deferred tax assets that, based on available evidence, are not expected to be realized.

The Company recognizes the tax benefit from uncertain tax positions if it is more likely than not that the tax positions will be sustained on examination by
the  tax  authorities,  based  on  the  technical  merits  of  the  position.  The  tax  benefit  is  measured  based  on  the  largest  benefit  that  has  a  greater  than  50%
likelihood of being realized upon ultimate settlement. It is the Company’s policy to include interest and penalties related to tax positions as a component of
income tax expense.

Concentration of Credit Risks
The Company maintains its cash and cash equivalents in bank deposit accounts, which, at times, may exceed federally insured limits. The Company has not
experienced  any  losses  in  such  accounts;  however,  amounts  in  excess  of  the  federally  insured  limit  may  be  at  risk  if  the  bank  experiences  financial
difficulties. As of December 31, 2021 and 2020 the Company had $83,312,524 and $9,936,806, respectively, in cash balances in excess of federally insured
limits, primarily at Bank of America/Merrill Lynch.

Research and Development
The Company expenses research and development expenses as incurred. There was no research and development expense for the years ended December
31, 2021 and 2020. 

F-12

 
   
 
 
 
 
 
 
 
 
  
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

Stock-based Compensation
The  Company  uses  the  fair  value  method  to  account  for  stock-based  compensation.  The  fair  value  of  the  equity  instrument  is  charged  directly  to
compensation expense and additional paid-in capital over the period during which services are rendered. The fair value of each award is estimated on the
date of each grant.

For restricted stock awards, the fair value is based on the market value of the Company’s common stock on the date of grant. For market based restricted
stock units, the fair value is estimated using a Monte Carlo simulation model. This valuation technique includes estimating the movement of stock prices
and the effects of volatility, interest rates and dividends.

For options, fair value is estimated using the Black-Scholes option pricing model that uses the following assumptions. Estimated volatilities are based on
the historical volatility of the Company’s common stock over the same period as the expected term of the options. The expected term of options granted
represents the period of time that options granted are expected to be outstanding. The Company uses historical data to estimate option exercise behavior
and to determine this term. The risk-free rate used is based on the U.S. Treasury yield curve in effect at the time of the grant using a time period equal to the
expected option term. The Company has never paid dividends and do not expect to pay any dividends in the future.

Expected dividend yield
Risk free interest rate
Expected option term
Turnover/forfeiture rate
Expected volatility
Weighted average grant date fair value

2021

2020

0%
0%   
    0.19% - 0.67%    0.16% - 1.63%

 3.5 years 

0%   
67 % - 70%   
  $
26.36 

 3.5 years 

0%
65 % - 71%

5.49 

  $

The Black-Scholes option valuation model and other existing models were developed for use in estimating the fair value of traded options that have no
vesting  restrictions  and  are  fully  transferable.  These  option  valuation  models  require  the  input  of,  and  are  highly  sensitive  to,  subjective  assumptions
including  the  expected  stock  price  volatility.  The  Company’s  stock  options  have  characteristics  significantly  different  from  those  of  traded  options,  and
changes in the subjective input assumptions could materially affect the fair value estimate.

Loss Per Common and Common Equivalent Share
The computation of basic (loss) earnings per common share is computed using the weighted average number of common shares outstanding during the
year. The computation of diluted (loss) earnings per common share is based on the basic weighted average number of shares outstanding during the year
plus common stock equivalents, which would arise from the exercise of options and warrants outstanding using the treasury stock method and the average
market price per share during the year. The number of common shares potentially issuable upon the exercise of certain options that were excluded from the
diluted  loss  per  common  share  calculation  in  2020  was  820,059  related  to  options,  and  91,667  related  to  restricted  stock  units,  for  a  total  of  911,726
because they are anti-dilutive, as a result of a net loss for the year ended December 31, 2020.

F-13

 
 
 
 
 
 
 
 
 
 
 
   
   
   
   
   
   
   
 
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 2 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

The computation of weighted average shares outstanding and the basic and diluted earnings per common share for the years ended December 31, 2021 and
2020 consisted of the following:

Year ended December 31, 2021

Basic EPS

Diluted EPS

Year ended December 31, 2020

Basic EPS

Diluted EPS

  Net Income    

Shares

Per Share
Amount

  $

  $

378,079     

17,228,019    $

378,079     

17,690,489    $

0.02 

0.02 

Net (Loss)

Shares

Per Share
Amount

  $

(2,207,127)    

14,827,923    $

  $

(2,207,127)    

14,827,923    $

(0.15)

(0.15)

Impairment of Long-Lived Assets
The Company continually monitors events and changes in circumstances that could indicate carrying amounts of long-lived assets may not be recoverable.
When  such  events  or  changes  in  circumstances  are  present,  the  Company  assesses  the  recoverability  of  long-lived  assets  by  determining  whether  the
carrying  value  of  such  assets  will  be  recovered  through  undiscounted  expected  future  cash  flows.  If  the  total  of  the  future  cash  flows  is  less  than  the
carrying amount of those assets, the Company recognizes an impairment loss based on the excess of the carrying amount over the fair value of the assets.
Assets to be disposed of are reported at the lower of the carrying amount or the fair value less costs to sell.

Segment reporting
We  operate  in  one  reportable  segment.  Overall,  our  business  involves  connecting  life  science  companies  to  patients  and  providers.  We  have  a  common
customer base for all of our solutions, which are primarily all communications with healthcare providers or patients on behalf of life science customers.
Our customers are geographically located in the U.S although we have two technology centers located internationally. We do not prepare separate internal
income statements by solutions as our focus is on selling enterprise arrangements covering multiple solutions that span the entire patient journey with a
specific brand.

Recently Issued Accounting Guidance
  In  December  2019,  the  FASB  issued  ASU  No.  2019-12,  Income  Taxes  (Topic  740):  Simplifying  the  Accounting  for  Income  Taxes.  ASU  2019-12  is
intended to improve consistent application and simplify the accounting for income taxes. ASU 2019-12 removes certain exceptions to the general principles
in Topic 740 and clarifies and amends existing guidance. ASU 2019-12 was effective for us as of January 1, 2021 The adoption of this standard did not
have a material effect on our financial position, results of operations, or cash flows.

Not Yet Adopted

ASU Topic 2021-08 Business Combinations (Topic 805), Accounting for Contract Assets and Contract Liabilities from Contracts with Customers, which
requires contract assets and contract liabilities acquired in a business combination to be recognized and measured by the acquirer on the acquisition date in
accordance with ASC 606, Revenue from Contracts with Customers, as if it had originated the contracts. The standard is effective for the Company's fiscal
year beginning January 1, 2023, with early adoption permitted. The Company is currently evaluating the effect of this pronouncement on its Consolidated
Financial Statements, but it is not expected to have a material impact.

F-14

 
 
 
 
 
 
   
 
   
     
     
 
 
   
      
      
  
 
 
 
   
   
 
   
     
     
 
 
   
      
      
  
 
 
 
 
 
  
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 3 – PREPAID EXPENSES

Prepaid expenses consisted of the following as of December 31, 2021 and 2020:

Prepaid revenue share  and exclusivity payments
EHR access fees
Data
Insurance
Other
Total prepaid expenses

NOTE 4 – PROPERTY AND EQUIPMENT

2021
4,266,668     
250,000     
168,462     
156,327     
789,198     
5,630,655    $

2020
3,750,000 
317,726 
29,408 
77,887 
281,590 
4,456,611 

  $

The Company owned equipment recorded at cost, which consisted of the following as of December 31, 2021 and 2020:

Computer equipment
Furniture and fixtures

Less accumulated depreciation
Property and equipment, net

2021

2020

267,917    $
200,250     
468,167     
324,349     
143,818    $

169,247 
198,665 
367,912 
219,058 
148,854 

  $

  $

Depreciation expense was $105,360 and $95,202 for the years ended December 31, 2021 and 2020, respectively.

NOTE 5 – INTANBIGLE ASSETS

Goodwill

Our goodwill is related to the acquisitions of RMDY Health, Inc. in 2019 and CareSpeak Communications in 2018. Goodwill is generally not amortizable
for tax purposes and is not amortizable for financial statement purposes.

F-15

 
 
 
 
 
 
 
 
   
 
   
   
   
   
   
 
 
 
 
 
   
 
   
 
   
   
 
 
 
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 5 – INTANBIGLE ASSETS (CONTINUED)

Intangible Assets

Intangible assets included on the consolidated balance sheets consist of the following:

December 31, 2021

Patent rights

Technology Assets

Other intangible assets

Tradename
Non-compete agreements
Customer relationships

Total other

Total Intangibles

Patent rights

Technology Assets

Other intangible assets

Tradename
 Non-compete agreements
 Customer relationships

Total other

Total Intangibles

  $
  $

  $

  $

  $
  $

  $

  $

F-16

Gross 
Carrying 
Amount

Accumulated 
Amortization    
1,207,872     
3,959,804     

3,362,898    $
8,548,930    $

Net
2,155,026     
4,589,126     

3,586,000    $
1,093,000     
923,000     
5,602,000     
17,513,828    $

537,900     
899,635     
261,963     
1,699,498     
6,867,174     

3,084,100     
193,365     
661,037     
3,902,502     
10,646,654     

December 31, 2020

Gross 
Carrying 
Amount

Accumulated 
Amortization    
991,818     
2,932,943     

3,341,388    $
8,184,765    $

Net
2,349,570     
5,251,822     

3,586,000    $
1,093,000     
923,000     
5,602,000     
17,128,153    $

298,833     
611,885     
171,730     
1,082,448     
5,007,209     

3,287,167     
481,115     
751,270     
4,519,552     
12,120,944     

Weighted 
Average Life 

Remaining  
9.6 

4.9 

12.7 
0.6 
8.4 

Weighted 
Average Life 

Remaining  
11.5 

7.7 

13.7 
1.6 
9.8 

 
  
 
 
 
 
 
 
   
 
 
 
 
   
   
   
      
      
      
  
   
   
   
  
  
 
 
 
   
 
 
 
 
   
   
   
      
      
      
  
   
   
   
  
  
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 5 – INTANBIGLE ASSETS (CONTINUED)

Intangibles are being amortized on a straight-line basis over the following estimated useful lives.

Patents
Tradenames
Non-compete agreements
Customer relationships
Technology assets

    15 – 17 years 
15 years 
2 – 4 years 
8 – 15 years 
3 – 10 years 

The Company recorded amortization expense of $1,859,965 and $1,875,882 in the years ended December 31, 2021 and 2020, respectively. Expected future
amortization expenses of the intangibles assets as of December 31, 2021 is as follows:

Year ended December 31,

2022
2023
2024
2025
2026
Thereafter
Total

NOTE 6 – DEFERRED REVENUE

  $

  $

1,532,756 
1,203,639 
1,203,639 
1,131,058 
1,009,499 
4,566,063 
10,646,654 

The Company has several signed contracts with customers for the distribution of financial messaging, or other services, which include payment in advance.
The  payments  are  not  recorded  as  revenue  until  the  revenue  is  earned  under  its  revenue  recognition  policy  discussed  in  Note  2.  Deferred  revenue  was
$1,389,908 and $285,795 as of December 31, 2021 and 2020, respectively. These contracts are all short term in nature and all revenue is expected to be
recognized within 12 months, or less. Following is a summary of activity in the deferred revenue account for the year ended December 31, 2021.

Balance January 1, 2021
Revenue recognized
Amount collected
Balance December 31, 2021

Following is a summary of activity in the deferred revenue account for the year ended December 31, 2020.

Balance January 1, 2020
Revenue recognized
Amount collected
Balance December 31, 2020

F-17

  $

  $

285,795 
(18,006,973)
19,111,086 
1,389,908 

  $

  $

580,014 
(16,260,166)
15,680,152 
285,795 

 
 
 
 
 
   
   
   
   
  
 
   
 
   
   
   
   
   
 
 
 
   
   
 
 
   
   
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 7 – RELATED PARTY TRANSACTIONS

During the year ended December 31, 2010, the Company acquired the technical contributions and assignment of all exclusive rights to and for a key patent
in process at the time from a former CEO in exchange for a total payment in shares of common stock and options valued at $930,000 at the time of the
acquisition and recorded the patent at that cost. That patent remains in Patents on the consolidated balance sheet as of December 31, 2021.

Jim Lang, one of our Board Members, is the CEO of Eversana, a leading global provider of services to the life sciences industry. Eversana is similar to
other  customers  we  generate  revenue  from,  such  as  agencies  or  resellers.  During  the  year  ended  December  31,  2021,  we  have  recognized  $218,333  in
revenue from contracts engaged with Eversana. No revenues were recognized in 2020 related to contracts with Eversana. These contracts were sourced by
Eversana on behalf of life science customers of theirs. The contracts are at market rates and were generated in the normal course of business.

NOTE 8 – CONTINGENT PURCHASE PRICE

Our purchase of CareSpeak Communications contained a contingent element that would be paid only if the Company achieved certain patient engagement
revenues in 2019 and 2020. The total contingent payment could have been up to $3.0 million. The target patient engagement revenues were achieved in
both 2019 and in 2020. The calculated fair value of the contingent payment was $3,000,000 at December 31, 2019 and $1,610,813 at December 31, 2020.
The final required payment was made in 2021.

Our purchase of RMDY Health, Inc. also contained a contingent element that would be paid only if the Company achieves certain revenues in 2020 and
2021 related to the RMDY business. The total contingent payment could have been up to $30.0 million. The minimum payment was $1.0 million in each of
the two years. The calculated fair value of the contingent payment was $3,720,000 at December 31, 2019. We determined the fair value of the Contingent
Purchase Price Payable at December 31, 2019 using a Geometric-Brownian motion analysis of the expected revenue and resulting earnout payment using
inputs that include the spot price, a risk free rate of return of 1.4%, a term of 2 years, and volatility of 35%. During 2020, we reached agreement with the
former shareholders of RMDY to fix the liability at $3.75 million, payable in a combination of cash and stock. Because of the change in the share price
between the date of agreement and the date of payment, the amount recorded for the stock amount varied from the agreed amount. The liability was paid in
full during 2020 and was paid with a $3.0 million cash payment and the remainder in shares of common stock.

There was no contingent purchase price payable at December 31, 2021.

The total fair value of contingent purchase price payable at December 31, 2020 is as follows.

CareSpeak Communications, Inc.
RMDY Health
Total

Current

Long-Term    

  $

  $

1,610,813     
-     
1,610,813    $

              -    $
-     
-    $

Total
1,610,813 
- 
1,610,813 

F-18

 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
   
  
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 9 – STOCKHOLDERS’ EQUITY

Preferred Stock
The  Company  has  10,000,000  shares  of  preferred  stock,  $.001  par  value  per  share,  authorized  as  of  December  31,  2021.  No  shares  were  issued  or
outstanding in either 2020 or 2021.

Common Stock
The  Company  had  166,666,667  shares  of  common  stock,  $.001  par  value  per  share,  authorized  as  of  December  31,  2021.  There  were  17,860,975  and
15,223,340 shares of common stock issued and outstanding at December 31, 2021 and 2020, respectively. 

During the quarter ended March 31, 2021, in an underwritten primary offering, we issued 1,523,750 shares of our common stock for gross proceeds of
$75,425,625. In connection with this transaction, we incurred equity issuance costs of $4,754,089 related to payments to the underwriter, advisors and legal
fees associated with the transaction, resulting in net proceeds to the Company of $70,671,536.

The Company had a Director Compensation plan covering its independent non-employee Directors that was in effect through June 30, 2021. A total of
4,730 and 28,809 shares were granted and issued in the years ended December 31, 2021 and 2020, respectively, in connection with this compensation plan.
These shares were valued at $250,085 and $450,124, respectively. The plan was changed to grant restricted stock units under the Company’s 2021 Equity
compensation plan and those grants are reflected in the information in Note 10.

We  issued  1,105,822  shares  of  common  stock  and  received  proceeds  of  $4,864,231  in  2021  in  connection  with  the  exercise  of  options.  We  also  issued
414,705 shares of common stock and received proceeds of $2,488,394 in 2020 in connection with the exercise of options. 

We issued 3,333 shares of common stock in 2021 and 84,746 shares of common in stock in 2020 in connection with the vesting of restricted stock units and
discussed in greater detail in Note 10, Stock Compensation.

NOTE 10 – STOCK COMPENSATION

The Company sponsors two stock-based incentive compensation plans.

The first plan is known as the 2013 Incentive Plan (the “2013 Plan”) and was established by the Board of Directors of the Company in June 2013. The 2013
Plan, as amended, authorized the issuance of 3,000,000 shares of Company common stock. The amended plan was approved by shareholders. A total of
671,011  shares  of  common  stock  underlying  options  and  145,550  shares  of  common  stock  underlying  restricted  stock  unit  awards  were  outstanding  at
December 31, 2021. In connection with the adoption of a new plan in 2021, the Company froze the 2013 Plan. At December 31, 2021, there were no shares
available for grant under the 2013 Plan.

In 2021, the Company adopted a new plan known as the 2021 Equity Incentive Plan (“2021 Plan”). The plan was established by the Board of Directors and
approved  by  shareholders  in  August  2021.  A  total  of  2,500,000  shares  are  authorized  for  issuance  under  the  2021  Plan.  A  total  of  112,536  shares  of
common stock underlying options and 254,188 shares of common stock underlying restricted stock unit awards were outstanding at December 31, 2021. At
December 31, 2021, 2,133,276 shares were available for grant under the 2021 Plan.

F-19

 
 
 
 
 
 
 
 
 
 
 
 
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 10 – STOCK COMPENSATION (CONTINUED)

The 2021 Plan allows the Company to grant incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock, restricted stock
units, performance awards and other stock-based awards. Incentive stock options may only be granted to persons who are regular full-time employees of
the Company at the date of the grant of the option. Non-qualified options may be granted to any person, including, but not limited to, directors, officers,
employees and consultants, who the Company’s Board or Compensation Committee determines. The exercise price of options granted under the 2021 Plan
must be equal to at least 100% of the fair market value of our common stock as of the date of the grant of the option. Options granted under the 2021 Plan
are exercisable as determined by the Compensation Committee and specified in the applicable award agreement. In no event will an option be exercisable
after ten years from the date of grant.

The  compensation  cost  that  has  been  charged  against  income  related  to  options  for  the  years  ended  December  31,  2021  and  2020,  was  $2,709,781  and
$1,884,202, respectively. No income tax benefit was recognized in the consolidated statements of income and no compensation was capitalized in any of
the years presented.

The Company had the following option activity during the year ended December 31, 2021 and 2020:

Outstanding at January 1, 2020
Granted
Exercised
Expired or forfeited
Outstanding at December 31, 2020
Granted
Exercised
Expired or forfeited
Outstanding, December 31, 2021
Exercisable, December 31, 2021

Number of
Options

Weighted
average

exercise price    

Weighted
average
remaining
contractual life
(years)

Aggregate
intrinsic
value $

1,624,221    $
467,549    $
(420,586)   $
(125,666)   $
1,545,518    $
424,588    $
(1,137,065)   $
(49,494)   $
783,547    $
197,271    $

6.27     
11.39     
6.45     
13.09     
7.31     
54.34     
7.33     
24.57     
34.17     
10.87     

2.3    $

36,862,947 

3.4    $
2.1    $

23,368,961 
10,109,168 

F-20

 
 
 
 
 
 
 
 
 
   
   
 
   
      
  
   
      
  
   
      
  
   
      
  
   
   
      
  
   
      
  
   
      
  
   
   
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 10 – STOCK COMPENSATION (CONTINUED)

The table below reflects information for the total options outstanding at December 31, 2021

Range of Exercise Prices
$2.46 to $10.00
$10,00 to $20.00
$20.00 to $40.00
$40.00 to $60.00
$60.00 to $96.70
Total

The table below reflects information for the vested options outstanding at December 31, 2021.

Range of Exercise Prices
$2.46 to $10.00
$10,00 to $20.00
$20.00 to $40.00
$40.00 to $60.00
$60.00 to $96.70
Total

Weighted
average
remaining
contractual life
(years)

Number of
Options

127,005     
166,945     
180,561     
196,500     
112,536     
783,547     

78,669     
89,938     
28,664     
-     
-     
197,271     

Weighted
average
remaining
contractual life
(years)

Number of
Options

Weighted
average
exercise price  
4.05 
12.51 
30.52 
51.88 
75.19 
34.17 

1.1    $
2.8    $
3.9    $
4.3    $
4.7    $
3.4    $

Weighted
average
exercise price  
3.76 
13.36 
22.52 
- 
- 
10.87 

0.9    $
2.5    $
3.9    $
-     
-     
2.1    $

A summary of the status of the Company’s nonvested options as of December 31, 2021, and changes during the year ended December 31, 2021, is
presented below.

Nonvested Options
Nonvested at January 1, 2021
Granted
Vested
Forfeited
Nonvested at December 31, 2021

Weighted-
Average
Exercise Price  
12.44 
54.34 
11.23 
24.57 
42.01 

Options

331,006    $
424,588     
(119,823)    
(49,495)    
586,276    $

There is $9,685,867 of expense remaining to be recognized over a period of approximately 2.4 years related to options outstanding at December 31, 2021.

F-21

 
 
 
 
 
 
   
   
   
   
   
   
   
   
 
 
 
   
   
   
   
   
   
   
   
 
 
 
   
   
   
   
   
   
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 10 – STOCK COMPENSATION (CONTINUED)

The Company had the following restricted stock unit (“RSU”) activity during the years ended December 31, 2021 and 2020:

Outstanding at January 1, 2020
Granted
Shares issued
Outstanding at December 31, 2020
Granted
Forfeited
Shares issued
Outstanding at December 31, 2021

Number of
RSUs

Grant  date fair
value

Weighted
average
remaining
contractual life
(years)

90,000    $
94,746    $
(84,746)   $
100,000    $
303,556    $
(485)   $
(3,333)   $
399,738    $

10.43     
8.98     
7.54     
11.51     
66.30     
61.82     
21.20     
52.99     

2.4 

3.3 

The  Company  granted  restricted  stock  units  of  303,556  and  94,746  units  in  2021  and  2020,  respectively,  and  valued  at  $20,125,861  and  $850,985,
respectively. These restricted stock units vest over a period of 1.6 to 5 years. The Company recognized expense of $2,532,091 and $838,514 in 2021 and
2020, respectively, related to these restricted stock units. A total of $18,389,797 remains to be recognized at December 31, 2021 over a period of 3.0 years.

Of the restricted stock units issued in 2021, 182,938 are market-based awards that vest if the Company’s stock price hits certain price targets and maintains
that price for 30 days. A total of 60,191, 60,191, and 62,016 units vest if the stock price hits $98.87, $131.82, $164.78, respectively. As described in Note 2,
these  market-based  restricted  stock  units  were  valued  using  a  Monte  Carlo  simulation  model,  with  expected  vesting  in  1.6,  2.25,  and  2.71  years,
respectively, for the three price targets.

NOTE 11 – LEASES

In  February  2016,  the  Financial  Accounting  Standards  Board  (“FASB”)  issued  new  accounting  guidance  on  leases.  The  accounting  standard,  effective
January 1, 2019, requires virtually all leases to be recognized on the balance sheet. Under the guidance, we have elected not to separate lease and non-lease
components in recognition of the lease-related assets and liabilities, as well as the related lease expense.

We have operating leases with terms greater than 12 months for office space in three multitenant facilities, which are recorded as assets and liabilities. The
lease on our headquarters space in Rochester, Michigan expires November 30, 2023, with a renewal option through 2025, with monthly rent payable at
rates ranging from $6,384 to $6,688. We have assumed renewal of the lease. We also have a lease on office space in Cranbury, New Jersey, which expired
in January 2022 with a monthly payment of $3,158, as well as a lease of approximately $1,883 per month in Zagreb, Croatia expiring in 2024.

F-22

 
 
 
 
 
 
 
   
   
 
   
  
   
  
   
  
   
   
  
   
  
   
  
   
 
 
 
 
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 11 – LEASES (CONTINUED)

Lease-related assets, or right-of-use assets, are recognized at the lease commencement date at amounts equal to the respective lease liabilities, adjusted for
prepaid  lease  payments,  initial  direct  costs,  and  lease  incentives  received.  Lease-related  liabilities  are  recognized  at  the  present  value  of  the  remaining
contractual fixed lease payments, discounted using our incremental borrowing rate. Operating lease expense is recognized on a straight-line basis over the
lease term, while variable lease payments are expensed as incurred. 

For the years ended December 31, 2021 and 2020, the Company’s lease cost consisted of the following components, each of which is included in operating
expenses within the Company’s consolidated statements of operations:

Operating lease cost
Short-term lease cost (1)
Total lease cost

2021

2020

  $

  $

132,305    $
52,375     
184,680    $

119,954 
130,216 
250,170 

(1) Short-term lease cost includes any lease with a term of less than 12 months.

The table below presents the future minimum lease payments to be made under operating leases as of December 31, 2021:

For the year ending December 31,
2022
2023
2024
2025
Total
Less: present value discount
Total lease liabilities

103,418 
100,260 
80,550 
70,224 
354,452 
26,744 
327,708 

  $

The weighted average remaining lease term for operating leases is 3.6 years and the weighted average discount rate used in calculating the operating lease
asset and liability is 4.5%. Cash paid for amounts included in the measurement of lease liabilities was $124,919. For the year ended December 31, 2021,
payments on lease obligations were $142,284 and amortization on the right of use assets was $121,129. For the year ended December 31, 2020, payments
on lease obligations were $138,019 and amortization on the right of use assets was $104,805.

F-23

 
 
 
 
 
 
 
 
   
 
 
   
   
 
 
   
 
  
 
   
 
   
   
   
   
   
   
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 12 – MAJOR CUSTOMERS AND VENDORS

The Company had the following customers that accounted for 10% or greater of revenue in either 2021 or 2020. No other customers accounted for more
than 10% of revenue in either year presented.

Customer A
Customer B
Customer C

2021

2020

$

%

$

%

14,268,819     
5,206,305     
3,157,075     

23.0     
8.5     
5.2     

5,037,888     
4,824,454     
5,469,126     

11.6 
11.1 
12.1 

Our accounts receivable included 2 agencies that represented multiple customers that individually made up more than 10% of our accounts receivable at
December 31, 2021 in the percentages of 33.5% and 12.2%. As of December 31, 2020, our accounts receivable included 4 entities, including agencies that
represented  multiple  customers  that  individually  made  up  more  than  10%  of  our  accounts  receivable  in  the  percentages  of  19.7%,  16.2%,  15.8%  and
14.4%.

The Company generates its revenues through its EHR and ePrescribe partners. It had two key partners and/or vendors through which 10% or greater of its
revenue was generated in either 2021 or 2020 as set forth below. The amounts in the table below reflect the amount of revenue generated through those
partners. 

Partner A
Partner B

NOTE 13 – INCOME TAXES

2021

2020

$

%

$

%

33,041,503     
9,554,266     

53.9     
15.6     

22,813,574     
7,092,477     

52.7 
16.4 

As of December 31, 2021, the Company had net operating loss carry-forwards for federal income tax purposes of approximately $26.4 million, consisting
of pre-2018 losses in the amount of approximately $13.2 million that expire from 2021 through 2037, and post-2017 losses in the amount of approximately
$13.2 million that will never expire. These net operating losses are available to offset future taxable income. The Company was formed in 2006 as a limited
liability  company  and  changed  to  a  corporation  in  2007.  Activity  prior  to  incorporation  is  not  reflected  in  the  Company’s  corporate  tax  returns.  In  the
future,  the  cumulative  net  operating  loss  carry-forward  for  income  tax  purposes  may  differ  from  the  cumulative  financial  statement  loss  due  to  timing
differences between book and tax reporting.

F-24

 
 
 
 
 
 
 
   
 
 
 
   
   
   
 
   
   
   
 
 
 
 
 
   
 
 
 
   
   
   
 
   
   
  
 
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 13 – INCOME TAXES (CONTINUED)

The provision for Federal income tax consists of the following for the years ended December 31, 2021 and 2020:

Federal income tax benefit (expense) attributable to:
Current operations
State tax effect, net of federal benefit
State rate change
Change in fair value of contingent consideration
Option exercise benefits, net of Section 162M limitations
Other permanent items
Other adjustments
NOLs expiring
Valuation allowance
Net provision for federal income tax

Current tax benefit (expense) - Federal
Deferred tax benefit (expense) - Federal
Adjustment of valuation allowance from business combination
Total tax benefit (expense) on income

2021

2020

(79,000)   $
582,000     
397,000     
-     
2,171,000     
(9,000)    
(30,000)    
(26,000)    
(3,006,000)    
-    $

463,000 
- 
- 
(29,000)
207,000 
(7,000)
104,000 
(209,000)
(529,000)
- 

2021

2020

-    $
-     
-     
-    $

- 
- 
- 
- 

  $

  $

  $

  $

The cumulative tax effect of significant items comprising our net deferred tax amount at the expected rate of 21% is as follows as of December 31, 2021
and 2020:

Deferred tax asset attributable to:
Net operating loss carryover
Stock compensation
Operating lease liability
Fixed Assets
Other
Deferred tax asset

Deferred tax liabilities attributable to:
Intangibles
Operating lease right of use assets
Other
Deferred tax liability

Net deferred tax asset
Valuation allowance
Net deferred tax asset, net of valuation allowance

F-25

2021

2020

6,887,000    $
809,000     
88,000     
13,000     
85,000     
7,882,000    $

4,057,000 
353,000 
94,000 
- 
44,000 
4,548,000 

(2,490,000)   $
(88,000)    
(41,000)    
(2,619,000)   $
5,263,000     
(5,263,000)    
-    $

(2,181,000)
(94,000)
(16,000)
(2,291,000)
2,257,000 
(2,257,000)
- 

  $

  $

  $

  $
  $

  $

 
 
 
 
 
 
 
   
 
   
      
  
   
   
   
   
   
   
   
   
 
 
   
     
 
 
   
      
  
   
   
 
 
 
 
   
 
   
      
  
   
   
   
   
 
   
      
  
   
      
  
   
   
   
 
OPTIMIZERx CORPORATION
NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
DECEMBER 31, 2021

NOTE 13 – INCOME TAXES (CONTINUED)

The ultimate realization of deferred tax assets is dependent upon the Company’s ability to generate sufficient taxable income during the periods in which
the net operating losses expire and the temporary differences become deductible. The Company has determined that there is significant uncertainty that the
results of future operations and the reversals of existing taxable temporary differences will generate sufficient taxable income to realize the deferred tax
assets; therefore, a valuation allowance has been recorded. In making this determination, the Company considered historical levels of income, projections
for future periods, and the significant amount of tax deductions to be generated from the future exercise of stock options.

The tax years 2018 to 2021 remain open for potential audit by the Internal Revenue Service. There are no uncertain tax positions as of December 31, 2020
or December 31, 2021, and none are expected in the next 12 months. The Company’s foreign subsidiaries are cost centers that are primarily reimbursed for
expenses, as a result they generate an immaterial amount of income or loss. Pretax book income (loss) is all from domestic operations. Up to four years of
returns remain open for potential audit in foreign jurisdictions, however any audits for periods prior to ownership by the Company are the responsibility of
the previous owners.

Under certain circumstances issuance of common shares can result in an ownership change under Internal Revenue Code Section 382, which limits the
Company’s  ability  to  utilize  carry-forwards  from  prior  to  the  ownership  change.  Any  such  ownership  change  resulting  from  stock  issuances  and
redemptions could limit the Company’s ability to utilize any net operating loss carry-forwards or credits generated before this change in ownership. These
limitations can limit both the timing of usage of these laws, as well as the loss of the ability to use these net operating losses. It is likely that fundraising
activities have resulted in such an ownership change. 

NOTE 14 – COMMITMENTS AND CONTINGENT LIABILITIES

Legal

The Company is not involved in any legal proceedings.

Revenue-share contracts
The Company has contracts with various electronic health records systems and ePrescribe platforms, whereby we agree to share a portion of the revenue we
generate for eCoupons distributed through their networks. These contracts grant audit rights related to the payments to our partners, and, in some cases
would require us to pay for the audit if the audit determined there was an underpayment and the underpayment meets certain thresholds, such as 10%. From
time to time the Company enters into arrangements with a partner to acquire minimum amounts of messaging capabilities. As of December 31, 2021, the
Company had commitments for future minimum payments of $3.4 million that will be reflected in cost of revenues during the years from 2022 through
2023. Minimum payments are due in 2022 and 2023, in the amounts of $2.65 million and $0.75 million, respectively.

NOTE 15 – RETIREMENT PLAN

The Company sponsors a defined contribution 401(k) profit sharing plan which was adopted in December 2015, effective in January 2016. Under the terms
of the plan, the Company matches 100% of the first 3% of payroll contributed by the employee and 50% of the next 2% of payroll contributed by the
employee to a maximum of 4% of an employee’s payroll. There was expense of $343,221 and $373,027 recorded in 2021 and 2020, respectively, for the
Company’s contributions to the plan.

F-26

 
 
 
   
 
 
  
 
 
 
 
 
 
Item 9. Changes In and Disagreements with Accountants on Accounting and Financial Disclosure

None

Item 9A. Controls and Procedures

Evaluation of Disclosure Controls and Procedures.

We  maintain  disclosure  controls  and  procedures  designed  to  provide  reasonable  assurance  that  information  required  to  be  disclosed  in  reports  filed  or
submitted  under  the  Exchange  Act  is  recorded,  processed,  summarized  and  reported  within  the  time  periods  specified  in  the  Securities  and  Exchange
Commission’s rules and forms and accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer,
or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosures.

Our  management,  with  the  participation  of  our  Chief  Executive  Officer  and  our  Chief  Financial  Officer,  conducted  an  evaluation,  as  of  the  end  of  the
period covered by this report, of the effectiveness of our disclosure controls and procedures, as such term is defined in Exchange Act Rule 13a-15(e). Based
on this evaluation, our Chief Executive Officer and our Chief Financial Officer have concluded that, as of the end of the period covered by this report, our
disclosure controls and procedures, as defined in Rule 13a-15(e), were effective at the reasonable assurance level.

Management’s Report on Internal Control Over Financial Reporting.

The Company’s management is responsible for establishing and maintaining adequate internal control over financial reporting, as defined in Exchange Act
Rule 13a-15(f). Internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting
and  the  preparation  of  financial  statements  for  external  purposes  in  accordance  with  generally  accepted  accounting  principles  in  the  United  States  of
America. The Company’s internal control over financial reporting includes those policies and procedures that: 

● pertain  to  the  maintenance  of  records  that,  in  reasonable  detail,  accurately  and  fairly  reflect  the  transactions  and  dispositions  of  the  assets  of  the

Company;

● provide reasonable  assurance  that  transactions  are  recorded  as  necessary  to  permit  preparation  of  financial  statements  in  accordance  with  generally
accepted  accounting  principles,  and  that  receipts  and  expenditures  of  the  Company  are  being  made  only  in  accordance  with  authorizations  of
management and directors of the Company; and

● provide reasonable  assurance  regarding  prevention  or  timely  detection  of  unauthorized  acquisition,  use, or disposition of the  Company's  assets  that

could have a material effect on the financial statements.

Because  of  its  inherent  limitations,  any  system  of  internal  control  over  financial  reporting,  no  matter  how  well  defined,  may  not  prevent  or  detect
misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of
changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate. 

The Company’s management assessed the effectiveness of the Company’s internal control over financial reporting as of December 31, 2021. In making this
assessment,  management  used  the  criteria  set  forth  by  the  Committee  of  Sponsoring  Organizations  of  the  Treadway  Commission  (COSO)  in  Internal
Control — Integrated Framework (2013). Based on this assessment using those criteria, management concluded that the Company’s internal control over
financial reporting was effective as of December 31, 2021.

Our internal control over financial reporting as of December 31, 2021, has been audited by UHY LLP an independent registered public accounting firm, as
stated in their report which is included in Item 8 of this report and is incorporated by reference herein.

Changes in Internal Controls Over Financial Reporting.

There was no change in our internal control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act), that occurred during the quarter
ended December 31, 2021 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting. 

Item 9B. Other Information

None 

Item 9C. Disclosure Regarding Foreign Jurisdictions that Prevent Inspections. 

None

29

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Item 10. Directors, Executive Officers and Corporate Governance

PART III

Except for the information provided in PART I, Item 4.1, “Information About Our Executive Officers” and as set forth below, the required information is
incorporated by reference from our definitive proxy statement for our 2022 Annual Meeting of Shareholders, including, but not necessarily limited to, the
sections entitled “Proposal No. 1 Election of Directors, “Committees of the Board of Directors” and “Information Regarding Security Holders – Delinquent
Section 16(a) Reports.”

We have a Code of Business Conduct and Ethics (the “Code”) that applies to our directors, officers, and employees. Only the Board may grant a waiver of
any  provision  for  a  director,  executive  officer,  or  any  other  principal  financial  officer,  and  any  such  waiver,  or  any  amendment  to  the  Code,  will  be
promptly  disclosed  as  required  at  www.optimizerx.com.  The  Code  can  be  found  on  the  Company’s  website  at  www.optimizerx.com  under  “Investor
Relations—Governance.” The information on the website is not and should not be considered part of this Form 10-K and is not incorporated by reference
in this Form 10-K.

Item 11. Executive Compensation

The required information is incorporated by reference from our definitive proxy statement for our 2022 Annual Meeting of Shareholders, including, but not
necessarily limited to, the sections entitled “Director Compensation” and “Executive Compensation.

30

 
 
 
 
 
 
 
 
Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.  

Except for the information set forth below, the required information is incorporated by reference from our definitive proxy statement for our 2022 Annual
Meeting of Shareholders, including, but not necessarily limited to, the section entitled “Information Regarding Security Holders.”

Equity Compensation Plan Information

The following table details information regarding our existing equity compensation plans as of December 31, 2021:

Number of
securities to be
issued upon
exercise of
outstanding
options, warrants
and rights
(a)

  Weighted-
average exercise
price of
outstanding
options, warrants
and rights
(b)

  Number of
securities
remaining
available for
future issuance
under equity
compensation
plans (excluding
securities
reflected in
column (a))  
(c)

671,011     
145,550     
112,536     
254,653     
-     
1,183,750     

27.29     
   N/A     
75.19     
   N/A     
   N/A     

- 
- 
- 
2,132,791 
- 
2,132,791 

Plan Category

Equity compensation plans approved by security holders
      2013 Equity Compensation Plan – Options
      2013 Equity Compensation Plan – Restricted Stock Units
      2021 Equity Incentive Plan – Options
      2021 Equity Incentive Plan – Restricted Stock Units
Equity compensation plans not approved by security holders
Total

31

 
 
 
 
 
 
 
   
   
 
 
 
   
   
 
   
      
      
  
   
   
   
   
   
   
      
 
Item 13. Certain Relationships and Related Transactions, and Director Independence

The required information is incorporated by reference from our definitive proxy statement for our 2022 Annual Meeting of Shareholders, including, but not
necessarily limited to, the sections entitled “Certain Relationships and Related Transactions” and “Corporate Governance - Director Independence.”

Item 14. Principal Accounting Fees and Services

The required information is incorporated by reference from our definitive proxy statement for our 2022 Annual Meeting of Shareholders, including, but not
necessarily limited to, the sections entitled “Ratification of UHY LLP as Independent Registered Public Accounting Firm – Independent Registered Public
Accountant Fee Information” and “Ratification of UHY LLP as Independent Registered Public Accounting Firm – Pre-Approval Policies and Procedures.”

32

 
 
 
 
 
 
Item 15. Exhibits and Financial Statements Schedules

PART IV

(a) The consolidated financial statements and exhibits listed below are filed as part of this Annual Report on Form 10-K.

(1)

(2)

The Company’s consolidated financial statements, the notes thereto and the report of the Independent Registered Public Accounting Firm
are included in PART II, Item 8. “Financial Statements and Supplementary Data.”

Financial statement schedules have been omitted because they are not applicable, not required, or the required information is included in
the Consolidated Financial Statements or Notes thereto.

(3)

Exhibits. Reference is made to Item 15(b) below.

(b) Exhibits. The Exhibit Index, which immediately precedes the signature page, is incorporated by reference into this Annual Report on Form 10-K.

(c) Financial Statement Schedules. Reference is made to Item 15(a)(2) above.

33

 
 
 
 
 
 
 
 
 
 
Item 16. Form 10-K Summary

None

EXHIBIT INDEX

Exhibit 
Number
3.1

3.2

3.3

4.1**
10.1†

10.2†

10.3†

10.4†

10.5†

10.6†

10.7†

10.8†

Description

  Articles  of  Incorporation  of  OptimizeRx  Corporation  (the  “Company”)  Incorporated  by  reference  to  Exhibit  3.1  to  the  Company’s

Registration Statement on Form S-1 (Registration No. 333-155280) filed on November 12, 2008.

  Certificate of Correction, dated April 30, 2018. Incorporated by reference to Exhibit 3.5 to the Company’s Annual Report on Form 10-K for

the year ended December 31, 2018.

  Second  Amended  and  Restated  Bylaws  of  the  Company.  Incorporated  by  reference  to  Exhibit  3.1  to  the  Company’s  Current  Report  on

Form 8-K filed on June 25, 2021.

  Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934.
  Fourth Amended and Restated 2013 Equity Incentive Plan. Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on

Form 8-K filed on March 12, 2020.

  OptimizeRx 2021 Equity Incentive Plan. Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on

August 25, 2021.

  Form  of  Stock  Option  Award  for  grants  under  the  OptimizeRx  Corporation  2021  Equity  Incentive  Plan.    Incorporated  by  reference  to

Exhibit 10.2 to the Company’s Current Report on Form 8-K filed on August 25, 2021.

  Form  of  Performance  Stock  Option  Award  for  grants  under  the  OptimizeRx  Corporation  2021  Equity  Incentive  Plan.  Incorporated  by

reference to Exhibit 10.3 to the Company’s Current Report on Form 8-K filed on August 25, 2021.

  Form of Restricted Stock Unit Award for grants under the OptimizeRx Corporation 2021 Equity Incentive Plan. Incorporated by reference

to Exhibit 10.4 to the Company’s Current Report on Form 8-K filed on August 25, 2021.

  Form of Performance Restricted Stock Unit Award for grants under the OptimizeRx Corporation 2021. Incorporated by reference to Exhibit

10.5 to the Company’s Current Report on Form 8-K filed on August 25, 2021

  Amended Employment Agreement by and between the Company and William J. Febbo.  Incorporated by reference to Exhibit 10.1 to the

Company’s Current Report on Form 8-K filed on February 26, 2019.

  Amendment  to  the  Employment  Agreement  with  William  Febbo.  Incorporated  by  reference  to  Exhibit  10.4  to  the  Company’s  Annual

Report on Form 10-K for the year ended December 31, 2019.

10.9 †

  Addendum to the Employment Agreement with William J. Febbo. Incorporated by reference to Exhibit 10.1 to the Company’s Quarterly

Report on Form 10-Q for the quarter ended June 30, 2021.

10.10*†

  Third  Addendum  to  the  Employment  Agreement  with  William  J.  Febbo,.  Incorporated  by  reference  to  Exhibit  10.1  to  the  Company’s

Current Report on Form 8-K filed on October 19, 2021.

10.11†

  Amended Employment Agreement with Miriam Paramore. Incorporated by reference to Exhibit 10.2 to the Company’s Current Report on

Form 8-K filed on September 14, 2018.

10.12†

  Amendment to the Employment Agreement with Miriam Paramore. Incorporated by reference to Exhibit 10.6 to the Company’s Annual

Report on Form 10-K for the year ended December 31, 2019.

10.13†

  Letter Agreement by and between the Company and Miriam Paramore. Incorporated by reference to Exhibit 10.1 to the Company’s Current

Report on Form 8-K filed on December 22, 2021.

10.14†

  Employment Agreement by and between the Company and Stephen Silvestro. Incorporated by reference to Exhibit 10.1 to the Company’s

Current Report on Form 8-K filed on May 3, 2019.

10.15†

  Amendment to the Employment Agreement with Stephen Silvestro. Incorporated by reference to Exhibit 10.5 to the Company’s Annual

Report on Form 10-K for the year ended December 31, 2019.

10.16†

  Employment Agreement with Marion Odence-Ford. Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-

K filed on February 11, 2021.

34

 
 
 
 
 
 
 
10.17*†

  Offer  Letter  by  and  between  the  Company  and  Edward  Stelmakh.  Incorporated  by  reference  to  Exhibit  10.1  to  the  Company’s  Current

Report on Form 8-K filed on September 30, 2021.

14.1

  Code of Business Conduct and Ethics Incorporated by reference to Exhibit 14.1 to the Company’s Current Report on Form 8-K filed on

June 25, 2021.

21.1**
23.1**
31.1**

  List of Subsidiaries
  Consent of UHY LLP
  Certification of Chief Executive Officer pursuant to Securities Exchange Act Rule 13a-14(a)/15d-14(a), as adopted pursuant to Section 302

of the Sarbanes-Oxley Act of 2002

31.2**

  Certification of Chief Financial Officer pursuant to Securities Exchange Act Rule 13a-14(a)/15d-14(a), as adopted pursuant to Section 302

of the Sarbanes-Oxley Act of 2002

32.1**

  Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906

of the Sarbanes-Oxley Act of 2002

101.INS**
101.SCH
101.CAL
101.DEF
101.LAB
101.PRE
104

  Inline XBRL Instance Document
  Inline XBRL Schema Document
  Inline XBRL Calculation Linkbase Document
  Inline XBRL Definition Linkbase Document
  Inline XBRL Label Linkbase Document
  Inline Presentation Linkbase Document
  Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)

†

Management Contracts and Compensatory Plans, Contracts or Arrangements.

*

**

Exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The Company agrees to furnish supplementally a copy of any
omitted exhibit to the SEC upon request.
Provided herewith.

35

 
 
 
 
 
Pursuant to the requirements of Section 13 or 15(d) of the Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.

SIGNATURES

OptimizeRx Corporation

By:

/s/ William J. Febbo
William Febbo
Title: Chief Executive Officer
Date: February 28, 2022

By:

/s/ Edward Stelmakh 
Edward Stelmakh
Title: Chief Financial Officer

Chief Operations Officer

Date: February 28, 2022

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant
and in the capacities and on the dates indicated.

/s/ William J. Febbo
William J. Febbo

/s/ Edward Stelmakh
Edward Stelmakh

/s/ Gus D. Halas
Gus D. Halas 

/s/ James Lang
James Lang

/s/ Patrick Spangler
Patrick Spangler

/s/ Lynn Vos
Lynn Vos

/s/ Greg Wasson
Greg Wasson

Signature

Title

  Chief Executive Officer and Director

(principal executive officer)

Date

February 28, 2022

  Chief Financial Officer and Chief Operations Officer

February 28, 2022

(principal financial and accounting officer)

  Chairman

  Director

  Director

  Director

  Director

36

February 28, 2022

February 28, 2022

February 28, 2022

February 28, 2022

February 28, 2022

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
DESCRIPTION OF THE REGISTRANT’S SECURITIES
REGISTERED PURSUANT TO SECTION 12 OF THE
SECURITIES EXCHANGE ACT OF 1934

Exhibit 4.1

OptimizeRx Corporation has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended: our common stock,
par value $.001 per share (the “common stock”). References herein to “we,” “us” and “our company” refer to OptimizeRx Corporation  and not to any of
our subsidiaries.

DESCRIPTION OF COMMON STOCK

The  following  description  of  the  common  stock  of  OptimizeRx  Corporation    is  a  summary  and  does  not  purport  to  be  complete.  It  is  subject  to  and
qualified in its entirety by reference to our articles of incorporation and bylaws, each of which is incorporated by reference as an exhibit to the Annual
Report on Form 10-K of which this Exhibit is a part. We encourage you to read our articles of incorporation, bylaws and the applicable provisions of the
Nevada Revised Statutes (“NRS”) for additional information.

Description of Common Stock

Authorized Capitalization

Our  articles  of  incorporation  provide  for  authorized  capital  stock  of  166,666,667  shares  of  common  stock,  par  value  $0.001  per  share,  and  10,000,000
shares of undesignated preferred stock, par value $0.001 per share. The rights, preferences and privileges of the holders of common stock are subject to,
and may be adversely affected by, the rights of the holders of shares of any then outstanding preferred stock. As of the date hereof, no shares of preferred
stock are outstanding. Our board of directors, subject to the provisions of our articles of incorporation and limitations imposed by law, has the authority to
designate, from time to time and without stockholder approval, preferred stock in one or more series, and to prescribe with respect to each such series the
voting  powers,  if  any,  designations,  preferences,  and  relative,  participating,  optional,  or  other  special  rights,  and  the  qualifications,  limitations,  or
restrictions relating to such series.

Dividend Rights

Subject to preferences that may apply to shares of preferred stock outstanding at the time, the holders of our common stock are entitled to receive dividends
out of assets legally available at the times and in the amounts as our board may from time to time determine.

Voting Rights

Each  holder  of  record  of  our  common  stock  is  entitled  to  one  vote  for  each  share  of  our  common  stock  held  on  all  matters  submitted  to  a  vote  of  the
stockholders. If a quorum is present, unless our articles of incorporation, our bylaws, the rules or regulations of any stock exchange applicable to us, or
applicable law provide for a different proportion, action by the stockholders entitled to vote on a matter, other than the election of directors, is approved by
and is the act of the stockholders if the number of votes cast in favor of the action exceeds the number of votes cast in opposition to the action. If a quorum
is present, unless otherwise provided by our articles of incorporation or bylaws, directors shall be elected by a plurality of the votes cast.

No Preemptive or Other Rights

Holders of our common stock are not entitled to preemptive, subscription, cumulative voting or conversion rights and there are no redemption or sinking
fund provisions applicable to our common stock.

 
 
 
 
 
 
 
 
 
 
 
 
 
Right to Receive Liquidation Distributions

In  the  event  of  our  liquidation,  dissolution  or  winding  up,  holders  of  our  common  stock  will  be  entitled  to  share  ratably  in  all  assets  remaining  after
payments to creditors and after satisfaction of the liquidation preference, if any, of the holders of any preferred stock that may at the time be outstanding.

Certain Anti-Takeover Effects of our Articles of Incorporation and Bylaws and Nevada Law

Certain provisions of our articles of incorporation and bylaws, and certain provisions of the NRS may have an effect of delaying, deferring or preventing a
change in control of the Company.

Undesignated  Preferred  Stock.  Our  board  of  directors  is  authorized  to  approve  the  issuance  of  preferred  stock  without  stockholder  approval  and  to
determine the number of shares, the designations and the relative preferences, rights, restrictions and qualifications of any series of preferred stock. As a
result, our board of directors could, without stockholder approval, authorize the issuance of preferred stock with voting, dividend, redemption, liquidation,
sinking fund, conversion and other rights that could proportionately reduce, minimize or otherwise adversely affect the voting power and other rights of
holders of the Company’s capital stock or that could have the effect of delaying, deferring or preventing a change in control.

No Stockholder Action by Written Consent. Our bylaws prohibit stockholders from acting by written consent. Accordingly, stockholder action must take
place at an annual or a special meeting of the Company’s stockholders.

Board Vacancies.  Subject to any rights of the holders of preferred stock, if any, vacancies on our board of directors, howsoever resulting, may be filled
only by a majority of the remaining directors, even if less than a quorum, or by a sole remaining director. Any director elected to fill a vacancy shall hold
office for a term expiring at the next annual meeting of stockholders and until such director’s successor is duly elected and qualified.

Removal of Directors. Our bylaws provide that, subject to any rights of the holders of preferred stock, if any, and except as otherwise provided in the NRS,
any director, or the entire Board, may be removed from office by the affirmative vote of the holders of not less than two-thirds of the voting power of the
issued and outstanding stock entitled to vote at an annual or special meeting of the stockholders duly noticed and called in accordance with our bylaws.
NRS  78.335  generally  requires  the  vote  of  stockholders  representing  not  less  than  two-thirds  of  the  voting  power  of  the  issued  and  outstanding  stock
entitled to vote in order to remove an incumbent director.

 Advance Notice Requirements.  Stockholders wishing to nominate persons for election to our board of directors at an annual meeting or to propose any
business to be considered by our stockholders at an annual or special meeting must comply with certain advance notice and other requirements set forth in
our bylaws. Likewise, if our board of directors has determined that directors shall be elected at a special meeting of stockholders, stockholders wishing to
nominate persons for election to our board of directors at such special meeting must comply with certain advance notice and other requirements set forth in
our bylaws.

Nevada  Anti-Takeover  Statutes.  Nevada’s  “acquisition  of  controlling  interest”  statutes  (NRS  78.378  through  78.3793,  inclusive)  contain  provisions
governing  the  acquisition  of  a  controlling  interest  in  certain  Nevada  corporations.  These  “control  share”  laws  provide  generally  that  any  person  that
acquires  a  “controlling  interest”  in  certain  Nevada  corporations  may  be  denied  voting  rights,  unless  a  majority  of  the  disinterested  stockholders  of  the
corporation elects to restore such voting rights. These laws would apply to us as of a particular date if we were to have 200 or more stockholders of record
(at least 100 of whom have addresses in Nevada appearing on our stock ledger at all times during the 90 days immediately preceding that date) and do
business in the State of Nevada directly or through an affiliated corporation, unless our articles of incorporation or bylaws in effect on the tenth day after
the acquisition of a controlling interest provide otherwise. These laws provide that a person acquires a “controlling interest” whenever a person acquires
shares of a subject corporation that, but for the application of these provisions of the NRS, would enable that person to exercise (1) one-fifth or more, but
less than one-third, (2) one-third or more, but less than a majority or (3) a majority or more, of all of the voting power of the corporation in the election of
directors. Once an acquirer crosses one of these thresholds, shares which it acquired in the transaction taking it over the threshold and within the 90 days
immediately preceding the date when the acquiring person acquired or offered to acquire a controlling interest become “control shares” to which the voting
restrictions described above apply. 

2

 
 
 
 
 
 
 
  
 
 
 
 
Nevada’s  “combinations  with  interested  stockholders”  statutes  (NRS  78.411  through  78.444,  inclusive)  provide  that  specified  types  of  business
“combinations” between certain Nevada corporations and any person deemed to be an “interested stockholder” of the corporation are prohibited for two
years after such person first becomes an “interested stockholder” unless the corporation’s board of directors approves the combination (or the transaction by
which  such  person  becomes  an  “interested  stockholder”)  in  advance,  or  unless  the  combination  is  approved  by  the  board  of  directors  and  at  least  sixty
percent of the corporation’s voting power not beneficially owned by the interested stockholder, its affiliates and associates. Furthermore, in the absence of
prior approval certain restrictions may apply even after such two-year period. For purposes of these statutes, an “interested stockholder” is any person who
is (1) the beneficial owner, directly or indirectly, of 10% or more of the voting power of the outstanding voting shares of the corporation, or (2) an affiliate
or associate of the corporation and at any time within the two previous years was the beneficial owner, directly or indirectly, of 10% or more of the voting
power  of  the  then-outstanding  shares  of  the  corporation.  The  definition  of  the  term  “combination”  is  sufficiently  broad  to  cover  most  significant
transactions between a corporation and an “interested stockholder.” These laws generally apply to Nevada corporations with 200 or more stockholders of
record.

In  addition,  NRS  78.139  also  provides  that  directors  may  resist  a  change  or  potential  change  in  control  of  the  corporation  if  the  board  of  directors
determines  that  the  change  or  potential  change  is  opposed  to  or  not  in  the  best  interest  of  the  corporation  upon  consideration  of  any  relevant  facts,
circumstances, contingencies or constituencies pursuant to NRS 78.138(4).

3

 
 
 
 
 
 
 
List of Subsidiaries

OptimizeRx Corporation, A Michigan corporation

CareSpeak Communications, Inc., a New Jersey corporation

CareSpeak Communications D.O.O., a controlled foreign corporation located in Croatia.

RMDY Health, Inc., A Delaware corporation

Cyberdiet, a controlled foreign corporation located in Israel

Exhibit 21.1

 
 
 
 
 
 
 
 
 
Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following Registration Statements of OptimizeRx Corporation and Subsidiaries on Form S-3 (File No.
333-252844) and Form S-8 (File Nos. 333-259218; 333-23760; 333-230212, 333-210653 and 333-189439) of our reports dated February 28, 2022, with
respect to the consolidated financial statements of OptimizeRx Corporation and Subsidiaries as of December 31, 2021 and 2020 and the effectiveness of
internal control over financial reporting of OptimizeRx Corporation and Subsidiaries as of December 31, 2021, included in this Annual Report on Form 10-
K of OptimizeRx Corporation for the year ended December 31, 2021.

/s/ UHY LLP

Sterling Heights, Michigan
February 28, 2022

 
 
 
 
 
 
Exhibit 31.1

I, William J. Febbo, certify that;

CERTIFICATIONS

1.

I have reviewed this annual report on Form 10-K for the year ended December 31, 2021 of OptimizeRx Corp (the “registrant”);

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements  made,  in  light  of  the  circumstances  under  which  such  statements  were  made,  not  misleading  with  respect  to  the  period  covered  by  this
report;

3. Based  on  my  knowledge,  the  financial  statements,  and  other  financial  information  included  in  this  report,  fairly  present  in  all  material  respects  the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The  registrant’s  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

a. Designed  such  disclosure  controls  and  procedures,  or  caused  such  disclosure  controls  and  procedures  to  be  designed  under  our  supervision,  to
ensure  that  material  information  relating  to  the  registrant,  including  its  consolidated  subsidiaries,  is  made  known  to  us  by  others  within  those
entities, particularly during the period in which this report is being prepared;

b. Designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;

c. Evaluated  the  effectiveness  of  the  registrant’s  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d. Disclosed  in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that  occurred  during  the  registrant’s  most  recent
fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially
affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably

likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control

over financial reporting.

Date: February 28, 2022

/s/ William J. Febbo
By: William J. Febbo
Title: Chief Executive Officer, Principal Executive Officer

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Exhibit 31.2

I, Edward Stelmakh, certify that;

CERTIFICATIONS

1.

I have reviewed this annual report on Form 10-K for the year ended December 31, 2021 of OptimizeRx Corp (the “registrant”);

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the
statements  made,  in  light  of  the  circumstances  under  which  such  statements  were  made,  not  misleading  with  respect  to  the  period  covered  by  this
report;

3. Based  on  my  knowledge,  the  financial  statements,  and  other  financial  information  included  in  this  report,  fairly  present  in  all  material  respects  the

financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The  registrant’s  other  certifying  officer  and  I  are  responsible  for  establishing  and  maintaining  disclosure  controls  and  procedures  (as  defined  in
Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f))
for the registrant and have:

a. Designed  such  disclosure  controls  and  procedures,  or  caused  such  disclosure  controls  and  procedures  to  be  designed  under  our  supervision,  to
ensure  that  material  information  relating  to  the  registrant,  including  its  consolidated  subsidiaries,  is  made  known  to  us  by  others  within  those
entities, particularly during the period in which this report is being prepared;

b. Designed  such  internal  control  over  financial  reporting,  or  caused  such  internal  control  over  financial  reporting  to  be  designed  under  our
supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with generally accepted accounting principles;

c. Evaluated  the  effectiveness  of  the  registrant’s  disclosure  controls  and  procedures  and  presented  in  this  report  our  conclusions  about  the

effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d. Disclosed  in  this  report  any  change  in  the  registrant’s  internal  control  over  financial  reporting  that  occurred  during  the  registrant’s  most  recent
fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially
affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the

registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably

likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control

over financial reporting.

Date: February 28, 2022

/s/ Edward Stelmakh
By:
Title: Chief Financial Officer, Principal Financial Officer

Edward Stelmakh

and Principal Accounting Officer

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
CERTIFICATION OF CHIEF EXECUTIVE OFFICER AND
CHIEF FINANCIAL OFFICER
PURSUANT TO
18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 32.1 

In connection with the annual Report of OptimizeRx Corp (the “Company”) on Form 10-K for the year ended December 31, 2021 filed with the Securities
and Exchange Commission (the “Report”), I, William J. Febbo, Chief Executive Officer of the Company, and I, Edward Stelmakh, certify, pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

1.

2.

The Report fully complies with the requirements of Section 13(a) of the Securities Exchange Act of 1934; and

The information contained in the Report fairly presents, in all material respects, the consolidated financial condition of the Company as of the dates
presented and the consolidated result of operations of the Company for the periods presented.

/s/ William J. Febbo

By:
Name: William J. Febbo
Title: Chief Executive Officer, Principal Executive Officer
Date: February 28, 2021

/s/ Edward Stelmakh

By:
Name: Edward Stelmakh
Title: Chief Financial Officer, Principal Financial Officer

and Principal Accounting Officer

Date: February 28, 2022

This certification has been furnished solely pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.