PYC Therapeutics Limited Annual Report 2014

Plain-text annual report

Annual Report and Financial Statements For the Year Ended 30 June 2014 Company Registration No. 4225086 This page is intentionally blank 2 Contents Officers and Professional Advisors Chairman’s Statement Chairman and Chief Executive Officer’s Statement The Strategic Report The Directors’ Report Independent Auditor’s Report to the members Income Statement Statement of financial position Statement of changes in equity Cash Flow Statement Notes on the Financial Statements Notice of Annual General Meeting Form of Proxy This page is intentionally blank 4 5 6 11 13 17 19 20 21 22 23 37 41 3 Form of Proxy Form of Proxy Directors’ Report Left Blank Intentionally Officers and Professional Advisers Officers and Professional Advisers Officers and Professional Advisers Officers and Professional Advisers Chairman and Chief Executive Officer’s Statement Officers and Professional Advisers Officers and Professional Advisers I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, Officers and Professional Advisers AUDITOR SECRETARY BANKER BANKER BANKER SECRETARY SECRETARY SECRETARY R J Jones R J Jones R J Jones Against Withheld Against Withheld AUDITOR Introduction DIRECTORS DIRECTORS DIRECTORS DIRECTORS SECRETARY SECRETARY SECRETARY REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE Officers and Professional Advisers Officers and Professional Advisers Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer The Directors submit their report and the audited financial statements of Physiomics Plc for the year Officers and Professional Advisers Officers and Professional Advisers DIRECTORS DIRECTORS Introduction Dr P B Harper Dr M P Chadwick Dr C D Chassagnole Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer Chairman Chief Executive Officer Chief Operating Officer Dr P B Harper Dr P B Harper Dr P B Harper Dr M P Chadwick Dr M P Chadwick Dr M P Chadwick Dr C D Chassagnole Dr C D Chassagnole Dr C D Chassagnole For For Offi cers and Professional Advisors Officers and Professional Advisers Officers and Professional Advisers The Company is principally engaged in providing services to pharmaceutical companies in the areas of Officers and Professional Advisers Officers and Professional Advisers 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix Officers and Professional Advisers Officers and Professional Advisers DIRECTORS Officers and Professional Advisers Officers and Professional Advisers Officers and Professional Advisers Officers and Professional Advisers of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form R J Jones Officers and Professional Advisers Chairman and Chief Executive Officer’s Statement Officers and Professional Advisers Officers and Professional Advisers There was a loss for the year after taxation amounting to £539,577 (2011 loss: £644,532). In view of 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year SECRETARY accumulated losses, and given the stage of the company’s development, the Directors are unable to The turnover of the Company increased to £135,306 (2011: £53,345) Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the The Directors consider that the key performance indicators are those that communicate the financial Officers and Professional Advisers performance and strength of the company as a whole, these being revenue, profitability and Officers and Professional Advisers 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ ended 30 June 2012. Principal Activities and Performance Review where indicated below (see notes below). where indicated below (see notes below). outsourced systems and computational biology. ORDINARY RESOLUTIONS ORDINARY RESOLUTIONS ended 30 June 2012. ended 30 June 2012. 2. To re-appoint Paul Harper as a Director. 2. To re-appoint Paul Harper as a Director. recommend the payment of a dividend. Performance Indicators their remuneration. their remuneration. Form of Proxy Form of Proxy Directors’ Report Left Blank Intentionally Form of Proxy Form of Proxy Directors’ Report Left Blank Intentionally Company to allot relevant securities up to an aggregate nominal amount of £150,000. Company to allot relevant securities up to an aggregate nominal amount of £150,000. Officers and Professional Advisers Officers and Professional Advisers Officers and Professional Advisers ORDINARY RESOLUTIONS ORDINARY RESOLUTIONS where indicated below (see notes below). where indicated below (see notes below). outsourced systems and computational biology. I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, Officers and Professional Advisers SPECIAL RESOLUTIONS SPECIAL RESOLUTIONS of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. The Directors submit their report and the audited financial statements of Physiomics Plc for the year Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. of (block capital)…………………………………………………………………………………………………………………………………………………………………………………….…………………………….. The Directors submit their report and the audited financial statements of Physiomics Plc for the year ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) DIRECTORS DIRECTORS DIRECTORS shareholders’ funds. DIRECTORS DIRECTORS Introduction ended 30 June 2012. □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) □ (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) Principal Activities and Performance Review notice. notice. DIRECTORS ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares ………………………………………………………………………………………………………………………………………in respect of ………………………………………………………Ordinary Shares December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will The Company is principally engaged in providing services to pharmaceutical companies in the areas of exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will The Company is principally engaged in providing services to pharmaceutical companies in the areas of exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form exercise his/her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form Dr C D Chassagnole Dr C D Chassagnole Dr M P Chadwick Dr M P Chadwick Dr M P Chadwick Dr P B Harper Dr P B Harper Chairman as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 17 December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how December 2012 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how • The operating loss was £577,922 (2011: £693,795) Dr M P Chadwick DIRECTORS Dr M P Chadwick Principal Activities and Performance Review Dr P B Harper Dr P B Harper DIRECTORS Dr P B Harper Dr P B Harper Dr P B Harper DIRECTORS ended 30 June 2012. DIRECTORS DIRECTORS I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, I/We (block capital)……………………………………………………………………………………………………………….……………………….…………….……………..…….……………..………..……, where indicated below (see notes below). where indicated below (see notes below). outsourced systems and computational biology. Dr M P Chadwick Dr C D Chassagnole ORDINARY RESOLUTIONS ORDINARY RESOLUTIONS Dr C D Chassagnole Dr C D Chassagnole Dr C D Chassagnole Dr M P Chadwick …………………………………………………………………………………………. …………………………………………………………………………………………. Dr C D Chassagnole For For Against Withheld Against Withheld Future Risks There was a loss for the year after taxation amounting to £539,577 (2011 loss: £644,532). In view of 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year There was a loss for the year after taxation amounting to £539,577 (2011 loss: £644,532). In view of Date …………………………………………………………………………………………………….………… 2012 Date …………………………………………………………………………………………………….………… 2012 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year Dr C D Chassagnole accumulated losses, and given the stage of the company’s development, the Directors are unable to accumulated losses, and given the stage of the company’s development, the Directors are unable to Dr C D Chassagnole SECRETARY SECRETARY SECRETARY SECRETARY SECRETARY ended 30 June 2012. ended 30 June 2012. ended 30 June 2012. ended 30 June 2012. NOTES NOTES 2. To re-appoint Paul Harper as a Director. 2. To re-appoint Paul Harper as a Director. recommend the payment of a dividend. 2. To re-appoint Paul Harper as a Director. 2. To re-appoint Paul Harper as a Director. recommend the payment of a dividend. R J Jones R J Jones R J Jones 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix R J Jones R J Jones Performance Indicators their remuneration. their remuneration. Performance Indicators their remuneration. their remuneration. meeting in person, your proxy appointment will automatically be terminated. meeting in person, your proxy appointment will automatically be terminated. REGISTERED OFFICE REGISTERED OFFICE REGISTERED OFFICE 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the The Directors consider that the key performance indicators are those that communicate the financial Company to allot relevant securities up to an aggregate nominal amount of £150,000. Company to allot relevant securities up to an aggregate nominal amount of £150,000. The Directors consider that the key performance indicators are those that communicate the financial Company to allot relevant securities up to an aggregate nominal amount of £150,000. Company to allot relevant securities up to an aggregate nominal amount of £150,000. The Magdalen Centre REGISTERED OFFICE REGISTERED OFFICE Dr P B Harper SPECIAL RESOLUTIONS SPECIAL RESOLUTIONS performance and strength of the company as a whole, these being revenue, profitability and performance and strength of the company as a whole, these being revenue, profitability and 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority The Magdalen Centre 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority Robert Robinson Avenue Robert Robinson Avenue Robert Robinson Avenue The Magdalen Centre conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. shareholders’ funds. conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. Robert Robinson Avenue shareholders’ funds. 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ Oxford Science Park Oxford Science Park Oxford Science Park Robert Robinson Avenue 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ notice. notice. The turnover of the Company increased to £135,306 (2011: £53,345) notice. notice. The turnover of the Company increased to £135,306 (2011: £53,345) Oxford Science Park Oxford Oxford Oxford • The operating loss was £577,922 (2011: £693,795) until the anticipated income is achieved. OX4 4GA OX4 4GA OX4 4GA Oxford Oxford Oxford Science Park • The operating loss was £577,922 (2011: £693,795) OX4 4GA SPECIAL RESOLUTIONS SPECIAL RESOLUTIONS Addressing the Risks The Magdalen Centre The Magdalen Centre The Magdalen Centre • At the 30 June 2012 the surplus of shareholders’ funds was £734,570 (2011: £755,511) OX4 4GA R J Jones Signature(s)…………………………………………………………………………………………………………………………………………………… Signature(s)…………………………………………………………………………………………………………………………………………………… • At the 30 June 2012 the surplus of shareholders’ funds was £734,570 (2011: £755,511) Signature(s)…………………………………………………………………………………………………………………………………………………… Signature(s)…………………………………………………………………………………………………………………………………………………… Interest rate risk …………………………………………………………………………………………. …………………………………………………………………………………………. Dr P B Harper Chief Executive Officer Dr P B Harper Dr M P Chadwick Chief Operating Officer SECRETARY Dr M P Chadwick SECRETARY Against Withheld Against Withheld For For R J Jones R J Jones R J Jones R J Jones SECRETARY SECRETARY REGISTERED OFFICE Dr PB Harper, PhD Paul Harper, PhD REGISTERED OFFICE DIRECTORS DIRECTORS R J Jones R J Jones Chairman Chairman The Magdalen Centre REGISTERED OFFICE Robert Robinson Avenue REGISTERED OFFICE Robert Robinson Avenue Dr P B Harper Oxford Science Park Oxford Science Park The Magdalen Centre The Magdalen Centre Oxford Oxford OX4 4GA Robert Robinson Avenue Robert Robinson Avenue OX4 4GA OX4 4GA OX4 4GA SECRETARY Oxford Oxford Oxford Science Park Oxford Science Park SECRETARY Oxford Oxford DIRECTORS OX4 4GA AUDITOR OX4 4GA AUDITOR DIRECTORS R J Jones AUDITOR AUDITOR Future Risks Date …………………………………………………………………………………………………….………… 2012 Date …………………………………………………………………………………………………….………… 2012 …………………………………………………………………………………………. …………………………………………………………………………………………. Future Risks Date …………………………………………………………………………………………………….………… 2012 Date …………………………………………………………………………………………………….………… 2012 NOTES NOTES NOTES NOTES The Company faces many risks on the way to building shareholder value. The process of winning major 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. contracts in a competitive environment is rarely simple and can be delayed for reasons outside the Dr M P Chadwick Dr P B Harper Shipleys LLP Shipleys LLP Shipleys LLP meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. contracts in a competitive environment is rarely simple and can be delayed for reasons outside the 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the Company’s control. This means the Company faces major uncertainties in its cash flow. meeting in person, your proxy appointment will automatically be terminated. meeting in person, your proxy appointment will automatically be terminated. 10 Orange Street 10 Orange Street 10 Orange Street 10 Orange Street Dr M P Chadwick Dr C D Chassagnole Capita Registrars Shipleys LLP 10 Orange Street 10 Orange Street The Company faces many risks on the way to building shareholder value. The process of winning major 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general 6. Any alteration to the form of proxy should be initialled. 6. Any alteration to the form of proxy should be initialled. Shipleys LLP Shipleys LLP Shipleys LLP AUDITOR AUDITOR Dr P B Harper REGISTRAR AUDITOR 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the Company’s control. This means the Company faces major uncertainties in its cash flow. meeting in person, your proxy appointment will automatically be terminated. meeting in person, your proxy appointment will automatically be terminated. 10 Orange Street 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other Haymarket Haymarket Haymarket Haymarket than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other Addressing the Risks than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the Addressing the Risks Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you The Board addresses the financial uncertainties by careful budget monitoring and by quickly responding will need to appoint someone other than the Chairman and give them the relevant instructions directly. will need to appoint someone other than the Chairman and give them the relevant instructions directly. Haymarket WC2H 7DQ WC2H 7DQ WC2H 7DQ London WC2H 7DQ Interest rate profile respect of that share. respect of that share. London London London London Haymarket Haymarket Haymarket Haymarket Haymarket Dr C D Chassagnole The Registry Shipleys LLP London Shipleys LLP London SECRETARY 10 Orange Street Chief Operating Officer Chief Operating Ofﬁcer 34 Beckenham Road WC2H 7DQ WC2H 7DQ Oxford WC2H 7DQ 10 Orange Street WC2H 7DQ SECRETARY Beckenham Oxford OX4 4GA London London Haymarket for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you The Board addresses the financial uncertainties by careful budget monitoring and by quickly responding 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint to variations. If there are delays in signing contracts then recruitment and capital expenditure is frozen The Company had no bank borrowings at the 30 June 2012. WC2H 7DQ R J Jones London 4TU not later than 48 hours before the time of the meeting. 4TU not later than 48 hours before the time of the meeting. will need to appoint someone other than the Chairman and give them the relevant instructions directly. will need to appoint someone other than the Chairman and give them the relevant instructions directly. more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint to variations. If there are delays in signing contracts then recruitment and capital expenditure is frozen until the anticipated income is achieved. proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed BANKER R J Jones REGISTERED OFFICE WC2H 7DQ BR3 2YU OX4 4GA London BANKER BANKER Kent more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. relation to the submission of a proxy appointment via CREST. relation to the submission of a proxy appointment via CREST. WC2H 7DQ BANKER REGISTERED OFFICE AUDITOR BANKER BANKER BANKER BANKER proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the until the anticipated income is achieved. the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or Interest rate risk 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or The Company finances its operations by cash and short term deposits. The Company’s policy on interest relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. National Westminster Bank Plc BANKER against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or The Company finances its operations by cash and short term deposits. The Company’s policy on interest abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. National Westminster Bank Plc expressly stated. expressly stated. 6. Any alteration to the form of proxy should be initialled. 6. Any alteration to the form of proxy should be initialled. rate management is agreed at board level and is reviewed on an ongoing basis. 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal Woollen Hall Woollen Hall Woollen Hall National Westminster Bank Plc National Westminster Bank Plc National Westminster Bank Plc Woollen Hall Woollen Hall Woollen Hall 6. Any alteration to the form of proxy should be initialled. 6. Any alteration to the form of proxy should be initialled. rate management is agreed at board level and is reviewed on an ongoing basis. or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. Other creditors, accruals and deferred income values do not bear interest. Castle Way Castle Way Castle Way Woollen Hall 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting Castle Way Robert Robinson Avenue Oxford Science Park WH Ireland Limited Haymarket Castle Way Oxford Science Park 11 St James's Square Oxford Science Park Haymarket London Oxford The Magdalen Centre Robert Robinson Avenue Shipleys LLP Southampton Southampton Castle Way SO14 2DE SO14 2DE Castle Way Castle Way (i) personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in precedence. precedence. REGISTERED OFFICE AUDITOR The Magdalen Centre The Magdalen Centre FINANCIAL ADVISER Shipleys LLP BANKER Interest rate risk BANKER or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. Other creditors, accruals and deferred income values do not bear interest. Interest rate profile respect of that share. respect of that share. 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in Castle Way Southampton Southampton Southampton Southampton SO14 2DE SO14 2DE SO14 2DE SO14 2DE Southampton OX4 4GA Woollen Hall Oxford, OX44GA Manchester Oxford SO14 2DE London WC2H 7DQ WC2H 7DQ SOLICITOR SOLICITOR 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 The Company had no bank borrowings at the 30 June 2012. SO14 2DE SOLICITOR 4TU not later than 48 hours before the time of the meeting. 4TU not later than 48 hours before the time of the meeting. 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in SOLICITOR SOLICITOR SOLICITOR Interest rate profile respect of that share. respect of that share. AUDITOR AUDITOR AUDITOR AUDITOR authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 The Company had no bank borrowings at the 30 June 2012. relation to the submission of a proxy appointment via CREST. relation to the submission of a proxy appointment via CREST. SOLICITOR 4TU not later than 48 hours before the time of the meeting. 4TU not later than 48 hours before the time of the meeting. 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in precedence. precedence. 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take Taylor Vinters LLP relation to the submission of a proxy appointment via CREST. relation to the submission of a proxy appointment via CREST. 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those Taylor Vinters LLP 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those 36 36 8 expressly stated. expressly stated. precedence. precedence. expressly stated. expressly stated. Merlin Place, Milton Road, Cambridge CB4 0DP Kingdom. Taylor Vinters LLP Taylor Vinters LLP Taylor Vinters LLP Merlin Place, Merlin Place, Merlin Place, Merlin Place, Milton Road, Milton Road, Milton Road, Milton Road, Cambridge Cambridge Cambridge Cambridge CB4 0DP CB4 0DP CB4 0DP CB4 0DP Kingdom. Kingdom. Kingdom. Kingdom. 36 36 8 36 36 8 Woollen Hall SO14 2DE OX4 4GA Castle Way M2 3WH Castle Way Southampton SOLICITOR Southampton SOLICITOR SO14 2DE AUDITOR SOLICITOR SO14 2DE AUDITOR BANKER BANKER Taylor Vinters LLP Taylor Vinters LLP Shipleys LLP SOLICITOR Merlin Place, SOLICITOR Merlin Place, 50 Broadway 10 Orange Street Shipleys LLP Milton Road, Milton Road, Haymarket 10 Orange Street Taylor Vinters LLP Westminster Taylor Vinters LLP Cambridge Cambridge cancer. London Haymarket Merlin Place, London Merlin Place, CB4 0DP CB4 0DP WC2H 7DQ Milton Road, London Cambridge Cambridge Woollen Hall CB4 0DP CB4 0DP Woollen Hall Castle Way Castle Way Southampton Milton Road, SW1H 0BLOX2 0JB WC2H 7DQ Cambridge Southampton SO14 2DE (ii) Cambridge CB4 0DP CB4 0DP BANKER Kingdom. Kingdom. BANKER Kingdom. Kingdom. SO14 2DE SOLICITOR SOLICITOR Kingdom. Kingdom. Woollen Hall Merlin Place, Merlin Place, Milton Road, Woollen Hall Castle Way Milton Road, Cambridge Castle Way Southampton Cambridge CB4 0DP Southampton SO14 2DE CB4 0DP 3 Taylor Vinters LLP Kingdom. Taylor Vinters LLP Merlin Place, SO14 2DE SOLICITOR SOLICITOR Merlin Place, Milton Road, Milton Road, Cambridge Cambridge CB4 0DP CB4 0DP The vision and strategy for Physiomics remains unchanged, and the Company has made good progress towards its declared goals in the period. Signing up two new major pharmaceutical companies to utilise Virtual Tumour represents an important landmark in establishing the Company's technology platform in the drug discovery process in oncology. In addition to signing Lilly Inc. earlier, adding two further top tier pharma companies this year would suggest that our strategy is working. While the initial revenues for first projects are always modest, since these usually take the form of pilot studies, the Directors believe that there are good prospects for increased business and revenue flow from such customers. In particular, such prospects could arise from internal policy decisions to use Virtual Tumour as a standard modality in drug discovery programmes. In addition, growing the customer base has increased our awareness of the potential for new decision and forecasting tools, leading us to develop Virtual Tumour Clinical. It continues to be the view of the Directors that development of a clinical version of Virtual Tumour will be a major source of future revenues, since a tool with this capability has been requested by most of our current and potential customers. The Company has also developed two new products, namely its drug combinations and regimens database and cardiac toxicity prediction model. These are designed to augment our credentials as a business committed to providing predictive tools to the pharma and healthcare Industry. Such tools are used by professionals to improve the outcomes of drug design, development, combination dosing strategies and clinical outcomes. Dr P B Harper Dr P B Harper DIRECTORS Dr M P Chadwick DIRECTORS Dr M P Chadwick Chairman Dr C D Chassagnole Dr C D Chassagnole Chief Executive Officer Dr P B Harper Dr P B Harper Chief Operating Officer Dr M P Chadwick SECRETARY Dr M P Chadwick SECRETARY Dr C D Chassagnole Dr C D Chassagnole R J Jones R J Jones SECRETARY SECRETARY DIRECTORS REGISTERED OFFICE Dr PB Harper, PhD Paul Harper, PhD REGISTERED OFFICE DIRECTORS R J Jones DIRECTORS Chairman R J Jones Officers and Professional Advisers Chairman Dr P B Harper Chairman and Chief Executive Officer’s Statement DIRECTORS Officers and Professional Advisers The Magdalen Centre Officers and Professional Advisers The Magdalen Centre Dr P B Harper Dr M P Chadwick The Magdalen Centre The Magdalen Centre The Magdalen Centre Dr P B Harper REGISTERED OFFICE Robert Robinson Avenue DIRECTORS REGISTERED OFFICE Robert Robinson Avenue Dr M P Chadwick Dr C D Chassagnole The Magdalen Centre Robert Robinson Avenue Robert Robinson Avenue Robert Robinson Avenue Dr P B Harper Dr M P Chadwick Oxford Science Park Officers and Professional Advisers Oxford Science Park Dr C D Chassagnole Oxford Science Park Oxford Science Park Oxford Science Park Robert Robinson Avenue Officers and Professional Advisers DIRECTORS Dr M P Chadwick The Magdalen Centre Dr C D Chassagnole Oxford DIRECTORS The Magdalen Centre Officers and Professional Advisers Oxford Oxford Science Park SECRETARY Oxford Oxford Oxford Dr C D Chassagnole Robert Robinson Avenue Chairman OX4 4GA Robert Robinson Avenue Chairman Officers and Professional Advisers OX4 4GA Chairman Dr P B Harper The vision and strategy for Physiomics remains unchanged, and the Company has made good Chairman SECRETARY Oxford OX4 4GA OX4 4GA OX4 4GA Chairman Dr P B Harper Oxford Science Park SECRETARY The vision and strategy for Physiomics remains unchanged, and the Company has made good Chief Executive Officer Chairman Dr P B Harper Dr P B Harper Dr P B Harper DIRECTORS Chief Executive Officer Chief Executive Officer Dr M P Chadwick Oxford Science Park Chief Executive Officer DIRECTORS Chief Executive Officer Dr M P Chadwick R J Jones OX4 4GA progress towards its declared goals in the period. Signing up two new major pharmaceutical SECRETARY Oxford Chief Operating Officer Chairman Dr M P Chadwick Dr M P Chadwick Chief Executive Officer Dr M P Chadwick progress towards its declared goals in the period. Signing up two new major pharmaceutical Chief Operating Officer Dr C D Chassagnole Chief Operating Officer • At the 30 June 2012 the surplus of shareholders’ funds was £734,570 (2011: £755,511) Oxford Chief Operating Officer Chief Operating Officer Dr C D Chassagnole Chairman R J Jones Signature(s)…………………………………………………………………………………………………………………………………………………… Signature(s)…………………………………………………………………………………………………………………………………………………… DIRECTORS Chief Executive Officer Chief Operating Officer Dr C D Chassagnole Dr C D Chassagnole Dr C D Chassagnole OX4 4GA R J Jones Chairman Dr P B Harper companies to utilise Virtual Tumour represents an important landmark in establishing the Chairman AUDITOR companies to utilise Virtual Tumour represents an important landmark in establishing the Chairman Dr P B Harper OX4 4GA AUDITOR Chief Executive Officer Chief Operating Officer REGISTERED OFFICE DIRECTORS Chief Executive Officer Dr M P Chadwick REGISTRAR AUDITOR REGISTRAR AUDITOR REGISTRAR AUDITOR R J Jones SECRETARY Chief Executive Officer Company's technology platform in the drug discovery process in oncology. In addition to Chief Executive Officer Dr M P Chadwick SECRETARY Company's technology platform in the drug discovery process in oncology. In addition to Chief Operating Officer Chief Operating Officer Dr C D Chassagnole REGISTERED OFFICE REGISTRAR Dr P B Harper REGISTERED OFFICE Chief Operating Officer Officers and Professional Advisers Chief Operating Officer Dr C D Chassagnole Shipleys LLP Officers and Professional Advisers signing Lilly Inc. earlier, adding two further top tier pharma companies this year would suggest Shipleys LLP signing Lilly Inc. earlier, adding two further top tier pharma companies this year would suggest The Company faces many risks on the way to building shareholder value. The process of winning major R J Jones Dr P B Harper The Magdalen Centre Capita Registrars Shipleys LLP Shipleys LLP Capita Registrars Capita Registrars Shipleys LLP Dr M P Chadwick REGISTERED OFFICE AUDITOR Officers and Professional Advisers R J Jones Officers and Professional Advisers 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general 10 Orange Street R J Jones SECRETARY AUDITOR 10 Orange Street that our strategy is working. While the initial revenues for first projects are always modest, contracts in a competitive environment is rarely simple and can be delayed for reasons outside the that our strategy is working. While the initial revenues for first projects are always modest, The Magdalen Centre meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. Dr M P Chadwick Robert Robinson Avenue The Registry 10 Orange Street The Registry 10 Orange Street The Registry 10 Orange Street Capita Registrars Shipleys LLP Dr C D Chassagnole SECRETARY The Magdalen Centre DIRECTORS Haymarket REGISTERED OFFICE 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the Haymarket Dr PB Harper, PhD Dr Mark Chadwick, PhD, MBA Dr Mark Chadwick, PhD, MBA Dr Christophe Chassagnole, PhD Mark Chadwick, PhD, MBA Paul Harper, PhD Mark Chadwick, PhD, MBA Christophe Chassagnole, PhD REGISTERED OFFICE Robert Robinson Avenue Oxford Science Park 10 Orange Street The Registry Dr C D Chassagnole 34 Beckenham Road Haymarket Haymarket 34 Beckenham Road 34 Beckenham Road Haymarket Company’s control. This means the Company faces major uncertainties in its cash flow. since these usually take the form of pilot studies, the Directors believe that there are good since these usually take the form of pilot studies, the Directors believe that there are good The Magdalen Centre Shipleys LLP Robert Robinson Avenue DIRECTORS Dr P B Harper E C King Dr C D Chassagnole Dr M P Chadwick R J Jones DIRECTORS London DIRECTORS Shipleys LLP London Chief Executive Officer Chairman R J Jones Chief Executive Officer Chief Executive Ofﬁcer Chairman Oxford Science Park Chief Executive Ofﬁcer Oxford 34 Beckenham Road Haymarket Chief Operating Officer London Beckenham London Beckenham Beckenham London SECRETARY Dr P B Harper Chairman 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other Robert Robinson Avenue 10 Orange Street Oxford Science Park DIRECTORS Chairman Chief Operating Ofﬁcer Chief Operating Offi cer Chief Executive Offi cer Chairman prospects for increased business and revenue flow from such customers. In particular, such DIRECTORS prospects for increased business and revenue flow from such customers. In particular, such WC2H 7DQ The Magdalen Centre 10 Orange Street The Magdalen Centre WC2H 7DQ than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the Chairman Dr P B Harper Dr M P Chadwick Chief Executive Officer The Magdalen Centre The Magdalen Centre The Magdalen Centre Oxford OX4 4GA Beckenham London SECRETARY Kent WC2H 7DQ Kent WC2H 7DQ Kent WC2H 7DQ Dr P B Harper Chairman REGISTERED OFFICE Chairman Dr M P Chadwick Chief Executive Officer Oxford Science Park Haymarket Oxford Chairman Dr P B Harper Robert Robinson Avenue prospects could arise from internal policy decisions to use Virtual Tumour as a standard Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible REGISTERED OFFICE Robert Robinson Avenue prospects could arise from internal policy decisions to use Virtual Tumour as a standard Haymarket Chief Executive Officer Dr M P Chadwick Dr C D Chassagnole Chief Operating Officer Robert Robinson Avenue Robert Robinson Avenue Robert Robinson Avenue Chairman Dr P B Harper Chief Executive Officer Dr M P Chadwick OX4 4GA Dr M P Chadwick Chief Executive Officer Dr C D Chassagnole Chief Operating Officer BR3 2YU BR3 2YU BR3 2YU Kent WC2H 7DQ R J Jones Oxford Science Park Chairman Dr P B Harper Oxford Chief Executive Officer Dr M P Chadwick for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you London OX4 4GA The Board addresses the financial uncertainties by careful budget monitoring and by quickly responding Oxford Science Park modality in drug discovery programmes. In addition, growing the customer base has increased Chief Operating Officer Dr C D Chassagnole Oxford Science Park Oxford Science Park Oxford Science Park London Chief Executive Officer Dr M P Chadwick The Magdalen Centre Chief Operating Officer Dr C D Chassagnole modality in drug discovery programmes. In addition, growing the customer base has increased will need to appoint someone other than the Chairman and give them the relevant instructions directly. will need to appoint someone other than the Chairman and give them the relevant instructions directly. Dr C D Chassagnole Chief Operating Officer REGISTERED OFFICE NOMINATED ADVISOR, BROKER REGISTRAR Oxford BR3 2YU R J Jones Chief Executive Officer Dr M P Chadwick Chief Operating Officer Dr C D Chassagnole OX4 4GA WC2H 7DQ The Magdalen Centre Officers and Professional Advisers Oxford BANKER to variations. If there are delays in signing contracts then recruitment and capital expenditure is frozen SECRETARY Oxford 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint Officers and Professional Advisers Chief Operating Officer Dr C D Chassagnole Robert Robinson Avenue our awareness of the potential for new decision and forecasting tools, leading us to develop WC2H 7DQ BANKER OX4 4GA Chief Operating Officer Dr C D Chassagnole our awareness of the potential for new decision and forecasting tools, leading us to develop Technology Development AUDITOR NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND REGISTERED OFFICE AND FINANCIAL ADVISER Robert Robinson Avenue Officers and Professional Advisers OX4 4GA more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the SECRETARY OX4 4GA Officers and Professional Advisers Oxford Science Park SECRETARY Virtual Tumour Clinical. It continues to be the view of the Directors that development of a SECRETARY proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed Oxford Science Park AUDITOR REGISTERED OFFICE NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER FINANCIAL ADVISER FINANCIAL ADVISER Officers and Professional Advisers AUDITOR Virtual Tumour Clinical. It continues to be the view of the Directors that development of a R J Jones SECRETARY Oxford Officers and Professional Advisers the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. SECRETARY Oxford WH Ireland Limited The Magdalen Centre clinical version of Virtual Tumour will be a major source of future revenues, since a tool with Shipleys LLP FINANCIAL ADVISER The Magdalen Centre R J Jones DIRECTORS AUDITOR BANKER OX4 4GA R J Jones 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an 'X'. To abstain from voting on a resolution, select the National Westminster Bank Plc REGISTRAR AUDITOR clinical version of Virtual Tumour will be a major source of future revenues, since a tool with OX4 4GA BANKER REGISTRAR AUDITOR R J Jones National Westminster Bank Plc Virtual Tumour product improvements (i) REGISTRAR REGISTERED OFFICE DIRECTORS REGISTRAR REGISTRAR REGISTRAR relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or relevant "Vote withheld" box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or Shipleys LLP 10 Orange Street The Magdalen Centre WH Ireland Limited National Westminster Bank Plc WH Ireland Limited National Westminster Bank Plc WH Ireland Limited National Westminster Bank Plc R J Jones Robert Robinson Avenue this capability has been requested by most of our current and potential customers. The Shipleys LLP Robert Robinson Avenue 11 St James's Square REGISTRAR Woollen Hall REGISTERED OFFICE REGISTRAR REGISTRAR REGISTRAR R J Jones this capability has been requested by most of our current and potential customers. The against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or Woollen Hall REGISTERED OFFICE REGISTRAR Dr P B Harper Chairman The Company finances its operations by cash and short term deposits. The Company’s policy on interest REGISTERED OFFICE DIRECTORS 10 Orange Street Haymarket National Westminster Bank Plc WH Ireland Limited Robert Robinson Avenue 11 St James's Square Woollen Hall 11 St James's Square Woollen Hall 11 St James's Square Woollen Hall REGISTRAR AUDITOR REGISTERED OFFICE Oxford Science Park Capita Registrars Shipleys LLP Shipleys LLP 10 Orange Street Company has also developed two new products, namely its drug combinations and regimens abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. Castle Way REGISTERED OFFICE Capita Registrars Shipleys LLP Chairman REGISTERED OFFICE DIRECTORS Oxford Science Park Manchester Chairman Dr P B Harper The Magdalen Centre Shipleys LLP Shipleys LLP Shipleys LLP Capita Registrars Capita Registrars Capita Registrars Dr M P Chadwick Chief Executive Officer Castle Way REGISTERED OFFICE Capita Registrars AUDITOR REGISTRAR Company has also developed two new products, namely its drug combinations and regimens Physiomics is constantly striving to improve the value-adding capability of Virtual Tumour, in rate management is agreed at board level and is reviewed on an ongoing basis. The Registry 10 Orange Street Haymarket London Oxford Science Park 11 St James's Square Woollen Hall Manchester Castle Way Manchester Castle Way Manchester Castle Way Oxford Capita Registrars 10 Orange Street National Westminster Bank Plc Haymarket REGISTRAR AUDITOR The Registry 10 Orange Street Capita Asset Services Shipleys LLP The Magdalen Centre Chairman The Magdalen Centre Capita Registrars Capita Registrars Capita Registrars database and cardiac toxicity prediction model. These are designed to augment our credentials Chief Executive Officer Southampton REGISTERED OFFICE REGISTRAR The Magdalen Centre Chief Executive Officer Dr M P Chadwick Robert Robinson Avenue 10 Orange Street 10 Orange Street 10 Orange Street The Registry The Registry The Registry Capita Registrars Dr C D Chassagnole Chief Operating Officer The Magdalen Centre Dr P B Harper National Westminster Bank Plc The Registry 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal Southampton 34 Beckenham Road Haymarket REGISTRAR M2 3WH Oxford, OX44GA London The Registry WC2H 7DQ Oxford Castle Way Manchester M2 3WH Southampton M2 3WH Southampton M2 3WH Southampton OX4 4GA database and cardiac toxicity prediction model. These are designed to augment our credentials Haymarket 34 Beckenham Road Haymarket Woollen Hall London The Registry 10 Orange Street Robert Robinson Avenue The Magdalen Centre Roger Jones, FCCA Dr Christophe Chassagnole, PhD Chief Executive Officer Robert Robinson Avenue The Registry The Registry The Registry particular by reducing the data requirements to calibrate the model. The Company has begun Chief Operating Officer Roger Jones, FCCA Christophe Chassagnole, PhD Robert Robinson Avenue SO14 2DE Oxford Science Park The Registry The Magdalen Centre Chief Operating Officer Dr C D Chassagnole Haymarket 34 Beckenham Road 34 Beckenham Road 34 Beckenham Road Chairman Dr P B Harper or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. The Magdalen Centre Capita Registrars Shipleys LLP as a business committed to providing predictive tools to the pharma and healthcare Industry. Robert Robinson Avenue Dr M P Chadwick 34 Beckenham Road Other creditors, accruals and deferred income values do not bear interest. Woollen Hall Beckenham London SO14 2DE 34 Beckenham Road Capita Registrars Shipleys LLP WC2H 7DQ London Beckenham OX4 4GA SO14 2DE SO14 2DE SO14 2DE M2 3WH Southampton Dr Christophe Chassagnole, PhD Roger Jones, FCCA 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting 34 Beckenham Road Haymarket Oxford Science Park London Christophe Chassagnole, PhD Roger Jones, FCCA Castle Way WC2H 7DQ Robert Robinson Avenue Oxford Science Park Chief Operating Officer 34 Beckenham Road 34 Beckenham Road 34 Beckenham Road Oxford Science Park Oxford 34 Beckenham Road Company secretary Chief Operating Officer London Beckenham Beckenham Beckenham SECRETARY The Magdalen Centre Capita Registrars as a business committed to providing predictive tools to the pharma and healthcare Industry. Robert Robinson Avenue Chief Executive Officer Dr M P Chadwick Robert Robinson Avenue 10 Orange Street The Registry Oxford Science Park Dr C D Chassagnole Company Secretary Chief Operating Ofﬁcer Beckenham WC2H 7DQ Kent a collaboration with the Swiss company, InSphero, aimed at using in vitro 3D ‘spheroid’ Such tools are used by professionals to improve the outcomes of drug design, development, Castle Way Capita Registrars personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in The Registry 10 Orange Street Beckenham WC2H 7DQ Kent Beckenham London Oxford SO14 2DE Oxford Science Park Oxford OX4 4GA Company secretary Beckenham Beckenham Beckenham Beckenham SECRETARY WC2H 7DQ Kent Kent Kent WC2H 7DQ Southampton Oxford Science Park Robert Robinson Avenue The Registry 34 Beckenham Road Haymarket Oxford Science Park Oxford Chief Operating Officer Dr C D Chassagnole Company Secretary SOLICITOR BR3 2YU Kent Such tools are used by professionals to improve the outcomes of drug design, development, 34 Beckenham Road Haymarket Southampton The Registry BR3 2YU SOLICITOR Kent combination dosing strategies and clinical outcomes. BR3 2YU WC2H 7DQ OX4 4GA cultures to replace xenografts, so that Physiomics could start to make predictions even before OX4 4GA BR3 2YU BR3 2YU BR3 2YU Kent R J Jones BANKER Kent Kent Kent SOLICITOR SOLICITOR SOLICITOR SOLICITOR BANKER AUDITOR Oxford Beckenham London OX4 4GA SECRETARY Oxford Science Park 34 Beckenham Road Oxford SO14 2DE 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of BR3 2YU Beckenham London 34 Beckenham Road SO14 2DE BR3 2YU combination dosing strategies and clinical outcomes. REGISTERED OFFICE NOMINATED ADVISOR, BROKER REGISTRAR BR3 2YU R J Jones authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 authority must be lodged at the offices of the Company's Registrars, Capita Registrars, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent BR3 OX4 4GA BR3 2YU BR3 2YU BR3 2YU Kent WC2H 7DQ BANKER Oxford AUDITOR SOLICITOR Beckenham OX4 4GA SECRETARY NOMINATED ADVISOR, BROKER AND BANKER BANKER xenograft experiments are initiated. To date the collaborators have tested one cell line and are Bircham Dyson Bell LLP National Westminster Bank Plc Taylor Vinters LLP Kent WC2H 7DQ NOMINATED ADVISOR, BROKER AND BANKER Beckenham Technology Development AUDITOR REGISTRAR NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND REGISTERED OFFICE Capita Registrars AND FINANCIAL ADVISER Taylor Vinters LLP NOMINATED ADVISOR, BROKER REGISTRAR BR3 2YU R J Jones OX4 4GA Kent FINANCIAL ADVISER Taylor Vinters LLP Taylor Vinters LLP Taylor Vinters LLP Shipleys LLP BANKER SOLICITOR NOMINATED ADVISOR, BROKER AND 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in BR3 2YU FINANCIAL ADVISER Merlin Place, Kent NOMINATED ADVISOR, BROKER AND REGISTRAR AUDITOR REGISTERED OFFICE NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER FINANCIAL ADVISER FINANCIAL ADVISER looking to expand the collaboration to test multiple cell lines relevant to different types of AUDITOR REGISTRAR SOLICITOR 50 Broadway Willow Court , Minns Business Park Merlin Place, REGISTRAR NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND Capita Registrars AND FINANCIAL ADVISER BR3 2YU R J Jones National Westminster Bank Plc Taylor Vinters LLP Shipleys LLP Merlin Place, Merlin Place, Merlin Place, 10 Orange Street FINANCIAL ADVISER The Magdalen Centre WH Ireland Limited The Registry BR3 2YU Milton Road, Capita Registrars Shipleys LLP FINANCIAL ADVISER The Magdalen Centre FINANCIAL ADVISER AUDITOR REGISTRAR NOMINATED ADVISOR, BROKER AND BANKER REGISTERED OFFICE 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take REGISTRAR FINANCIAL ADVISER FINANCIAL ADVISER FINANCIAL ADVISER National Westminster Bank Plc WH Ireland Limited Milton Road, AUDITOR REGISTRAR cancer. NOMINATED ADVISOR, BROKER AND BANKER National Westminster Bank Plc National Westminster Bank Plc WH Ireland Limited 10 Orange Street Woollen Hall Merlin Place, Milton Road, Milton Road, Milton Road, Virtual Tumour product improvements Haymarket Westminster 7 West Way (i) Taylor Vinters LLP National Westminster Bank Plc Capita Registrars Shipleys LLP 10 Orange Street The Registry The Magdalen Centre National Westminster Bank Plc National Westminster Bank Plc WH Ireland Limited WH Ireland Limited National Westminster Bank Plc WH Ireland Limited Robert Robinson Avenue Shipleys LLP Capita Registrars FINANCIAL ADVISER Cambridge Robert Robinson Avenue 11 St James's Square 34BeckenhamRoad WH Ireland Limited The Registry SOLICITOR NOMINATED ADVISOR, BROKER BANKER 11 St James's Square Woollen Hall Capita Registrars Taylor Vinters LLP REGISTRAR AUDITOR NOMINATED ADVISOR, BROKER AND REGISTERED OFFICE Cambridge FINANCIAL ADVISER 11 St James's Square Woollen Hall WH Ireland Limited National Westminster Bank Plc 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. Woollen Hall Haymarket Castle Way Milton Road, Cambridge Cambridge Cambridge London 10 Orange Street The Registry 34 Beckenham Road Haymarket WH Ireland Limited Robert Robinson Avenue National Westminster Bank Plc 11 St James's Square Woollen Hall Woollen Hall 11 St James's Square Woollen Hall 11 St James's Square Oxford Science Park Merlin Place, Woollen Hall NOMINATED ADVISOR, BROKER AND Shipleys LLP Capita Registrars The Registry 10 Orange Street The Magdalen Centre WH Ireland Limited National Westminster Bank Plc Virtual Tumour product improvements AND FINANCIAL ADVISER CB4 0DP Castle Way Manchester London Oxford Capita Registrars The Registry 10 Orange Street WH Ireland Limited WH Ireland Limited WH Ireland Limited Beckenham Oxford Science Park Manchester Capita Registrars Shipleys LLP FINANCIAL ADVISER Merlin Place, 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those Robert Robinson Avenue 11 St James's Square 34BeckenhamRoad CB4 0DP Manchester Castle Way Taylor Vinters LLP National Westminster Bank Plc 11 St James's Square Physiomics is constantly striving to improve the value-adding capability of Virtual Tumour, in 34 Beckenham Road Haymarket Beckenham London Oxford Science Park 11 St James's Square Manchester Castle Way Manchester Manchester Oxford Castle Way London Southampton CB4 0DP CB4 0DP CB4 0DP Cambridge WC2H 7DQ 10 Orange Street The Registry WH Ireland Limited National Westminster Bank Plc Haymarket 34 Beckenham Road Robert Robinson Avenue FINANCIAL ADVISER Woollen Hall Milton Road, Castle Way 11 St James's Square Southampton M2 3WH The Registry 10 Orange Street 34 Beckenham Road 11 St James's Square 11 St James's Square 11 St James's Square Capita Registrars Shipleys LLP WH Ireland Limited National Westminster Bank Plc The Registry 10 Orange Street The Magdalen Centre M2 3WH Southampton Merlin Place, WH Ireland Limited Woollen Hall Milton Road, Manchester Kent, BR3 2YU Oxford, OX44GA M2 3WH SW1H 0BLOX2 0JB Beckenham London Kent WC2H 7DQ Oxford Manchester M2 3WH Southampton Southampton M2 3WH M2 3WH Southampton OX4 4GA Haymarket 34 Beckenham Road 11 St James's Square Woollen Hall Beckenham London Manchester Beckenham Oxford Science Park Southampton SO14 2DE CB4 0DP WC2H 7DQ particular by reducing the data requirements to calibrate the model. The Company has begun Manchester Castle Way SO14 2DE Cambridge Southampton Virtual Tumour Clinical Physiomics is constantly striving to improve the value-adding capability of Virtual Tumour, in 34 Beckenham Road Beckenham Manchester Manchester Manchester (ii) 11 St James's Square Woollen Hall The Registry 10 Orange Street SO14 2DE WH Ireland Limited National Westminster Bank Plc 34 Beckenham Road Haymarket Robert Robinson Avenue Milton Road, 11 St James’s Square Castle Way Kent WC2H 7DQ Cambridge M2 3WH BR3 2YU OX4 4GA SO14 2DE M2 3WH Beckenham London Manchester Castle Way WC2H 7DQ Kent Oxford WH Ireland Limited National Westminster Bank Plc SO14 2DE M2 3WH Southampton CB4 0DP SO14 2DE a collaboration with the Swiss company, InSphero, aimed at using in vitro 3D ‘spheroid’ Kent, BR3 2YU M2 3WH Beckenham Manchester Castle Way Kent M2 3WH M2 3WH M2 3WH 34 Beckenham Road Haymarket 11 St James's Square London Beckenham Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Oxford Science Park Cambridge Manchester Southampton particular by reducing the data requirements to calibrate the model. The Company has begun BR3 2YU WC2H 7DQ Kent BR3 2YU Southampton M2 3WH CB4 0DP OX4 4GA Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United 11 St James's Square SOLICITOR SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United BANKER M2 3WH Southampton SO14 2DE Kent BR3 2YU SOLICITOR Beckenham London Manchester Kent WC2H 7DQ Oxford CB4 0DP M2 3WH SO14 2DE cultures to replace xenografts, so that Physiomics could start to make predictions even before Kingdom. NOMINATED ADVISOR, BROKER AND The work to adapt Virtual Tumour to work in humans is progressing. The first phase, to BANKER SOLICITOR AUDITOR REGISTRAR AUDITOR BR3 2YU SO14 2DE Physiomics Plc is a limited liability company incorporated in England & Wales and a collaboration with the Swiss company, InSphero, aimed at using in vitro 3D ‘spheroid’ Kingdom. Manchester SO14 2DE SOLICITOR Kingdom. Kingdom. Kingdom. BANKER Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United BR3 2YU SOLICITOR Kent WC2H 7DQ BR3 2YU M2 3WH OX4 4GA NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER REGISTRAR AUDITOR BANKER NOMINATED ADVISOR, BROKER AND xenograft experiments are initiated. To date the collaborators have tested one cell line and are National Westminster Bank Plc Shipleys LLP Bircham Dyson Bell LLP Taylor Vinters LLP M2 3WH develop and calibrate the model using literature data, will allow us to evaluate the predictive Taylor Vinters LLP domiciled in UnitedKingdom. cultures to replace xenografts, so that Physiomics could start to make predictions even before NOMINATED ADVISOR, BROKER AND Taylor Vinters LLP Kingdom. BANKER AUDITOR REGISTRAR BR3 2YU FINANCIAL ADVISER SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Capita Registrars Shipleys LLP BANKER NOMINATED ADVISOR, BROKER AND SOLICITOR FINANCIAL ADVISER AUDITOR Merlin Place, looking to expand the collaboration to test multiple cell lines relevant to different types of Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United SOLICITOR Willow Court , Minns Business Park 10 Orange Street 50 Broadway Merlin Place, NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER REGISTRAR National Westminster Bank Plc WH Ireland Limited Taylor Vinters LLP Capita Registrars Shipleys LLP The Registry 10 Orange Street Merlin Place, National Westminster Bank Plc NOMINATED ADVISOR, BROKER AND BANKER FINANCIAL ADVISER power of the model against known outcomes. The second phase involves using client data to Kingdom. Taylor Vinters LLP xenograft experiments are initiated. To date the collaborators have tested one cell line and are Shipleys LLP National Westminster Bank Plc Milton Road, Milton Road, Kingdom. cancer. National Westminster Bank Plc WH Ireland Limited FINANCIAL ADVISER The Registry 10 Orange Street Woollen Hall 11 St James's Square 34 Beckenham Road Haymarket Capita Registrars Westminster Haymarket 7 West Way BANKER NOMINATED ADVISOR, BROKER AND Taylor Vinters LLP WH Ireland Limited National Westminster Bank Plc FINANCIAL ADVISER Shipleys LLP AUDITOR REGISTRAR Merlin Place, National Westminster Bank Plc Milton Road, Woollen Hall Taylor Vinters LLP Merlin Place, Cambridge looking to expand the collaboration to test multiple cell lines relevant to different types of Taylor Vinters LLP 10 Orange Street Willow Court , Minns Business Park Cambridge Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in 11 St James's Square Woollen Hall 34 Beckenham Road Haymarket Castle Way Manchester Beckenham London National Westminster Bank Plc WH Ireland Limited Capita Registrars The Registry National Westminster Bank Plc WH Ireland Limited Merlin Place, Woollen Hall 11 St James's Square 10 Orange Street FINANCIAL ADVISER Milton Road, CB4 0DP Cambridge Woollen Hall Castle Way London Oxford London Merlin Place, Milton Road, Merlin Place, CB4 0DP Manchester Castle Way Beckenham London M2 3WH Southampton Kent WC2H 7DQ United Kingdom. WH Ireland Limited National Westminster Bank Plc Woollen Hall 11 St James's Square The Registry 11 St James's Square Milton Road, Manchester Castle Way Haymarket 34 Beckenham Road 7 West Way Haymarket WH Ireland Limited National Westminster Bank Plc Shipleys LLP Cambridge CB4 0DP Castle Way Southampton Milton Road, Milton Road, Cambridge SW1H 0BLOX2 0JB WC2H 7DQ 3 Southampton M2 3WH SO14 2DE WC2H 7DQ Kent BR3 2YU Castle Way Manchester Cambridge M2 3WH Southampton London 11 St James's Square 34 Beckenham Road Manchester Beckenham Virtual Tumour Clinical WH Ireland Limited National Westminster Bank Plc 11 St James's Square Woollen Hall (ii) 10 Orange Street London Oxford Cambridge CB4 0DP Southampton SO14 2DE Cambridge CB4 0DP SO14 2DE BR3 2YU M2 3WH Southampton CB4 0DP SO14 2DE WC2H 7DQ Manchester Beckenham M2 3WH Kent Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United 11 St James's Square Woollen Hall Manchester Castle Way Haymarket CB4 0DP Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United SO14 2DE CB4 0DP SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United NOMINATED ADVISOR, BROKER AND BANKER WC2H 7DQ SO14 2DE M2 3WH Kent BR3 2YU Kingdom. The work to adapt Virtual Tumour to work in humans is progressing. The first phase, to Manchester Castle Way M2 3WH Southampton London Physiomics Plc is a limited liability company incorporated in England & Wales and Virtual Tumour Clinical Kingdom. SOLICITOR Kingdom. NOMINATED ADVISOR, BROKER AND BANKER Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United FINANCIAL ADVISER SOLICITOR SOLICITOR 4 BR3 2YU M2 3WH Southampton SO14 2DE WC2H 7DQ develop and calibrate the model using literature data, will allow us to evaluate the predictive Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United domiciled in UnitedKingdom. Taylor Vinters LLP FINANCIAL ADVISER SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United BANKER Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United NOMINATED ADVISOR, BROKER AND SO14 2DE Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United The work to adapt Virtual Tumour to work in humans is progressing. The first phase, to Taylor Vinters LLP Physiomics Plc is a limited liability company incorporated in England & Wales and Merlin Place, WH Ireland Limited National Westminster Bank Plc power of the model against known outcomes. The second phase involves using client data to Kingdom. Taylor Vinters LLP Kingdom. Taylor Vinters LLP NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER Kingdom. SOLICITOR Merlin Place, WH Ireland Limited National Westminster Bank Plc Milton Road, 11 St James's Square Woollen Hall Taylor Vinters LLP Merlin Place, develop and calibrate the model using literature data, will allow us to evaluate the predictive domiciled in UnitedKingdom. Taylor Vinters LLP Merlin Place, FINANCIAL ADVISER SOLICITOR Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United BANKER Milton Road, Cambridge 11 St James's Square Woollen Hall Manchester Castle Way Merlin Place, Milton Road, Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Merlin Place, WH Ireland Limited National Westminster Bank Plc Milton Road, power of the model against known outcomes. The second phase involves using client data to Taylor Vinters LLP Cambridge CB4 0DP Manchester Castle Way M2 3WH Southampton Milton Road, Cambridge 3 WH Ireland Limited National Westminster Bank Plc 11 St James's Square Taylor Vinters LLP Milton Road, Merlin Place, Cambridge CB4 0DP M2 3WH Southampton SO14 2DE Cambridge CB4 0DP Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer Dr Mark Chadwick, PhD, MBA Mark Chadwick, PhD, MBA Chief Executive Officer Chief Executive Ofﬁcer Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer Chairman Chairman Chief Executive Officer Chief Executive Officer Chief Operating Officer Chief Operating Officer Officers and Professional Advisers Beckenham 34 Beckenham Road Robert Robinson Avenue The Registry 34 Beckenham Road REGISTRAR REGISTRAR Capita Registrars Capita Registrars The Registry 34 Beckenham Road Beckenham Beckenham Kent Kent BR3 2YU FINANCIAL ADVISER WH Ireland Limited WH Ireland Limited 11 St James's Square 11 St James's Square Manchester Manchester M2 3WH M2 3WH REGISTRAR REGISTRAR Chairman Capita Registrars Capita Registrars Chairman Chief Executive Officer REGISTRAR The Registry REGISTRAR The Registry DIRECTORS Chief Executive Officer Chief Operating Officer 34 Beckenham Road 34 Beckenham Road Chief Operating Officer Roger Jones, FCCA Roger Jones, FCCA Capita Registrars Dr P B Harper Dr M P Chadwick Beckenham Capita Registrars Beckenham Company secretary Company Secretary Dr C D Chassagnole Kent The Registry The Registry Kent BR3 2YU 34 Beckenham Road 34 Beckenham Road BR3 2YU SECRETARY Beckenham Beckenham Kent Kent NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND BR3 2YU FINANCIAL ADVISER FINANCIAL ADVISER BR3 2YU Capita Registrars REGISTRAR R J Jones REGISTRAR WH Ireland Limited NOMINATED ADVISOR, BROKER AND REGISTERED OFFICE NOMINATED ADVISOR, BROKER AND WH Ireland Limited Capita Registrars The Registry FINANCIAL ADVISER 11 St James's Square FINANCIAL ADVISER 11 St James's Square 34BeckenhamRoad Capita Registrars The Registry The Registry 34 Beckenham Road The Magdalen Centre Manchester Manchester Beckenham WH Ireland Limited M2 3WH M2 3WH WH Ireland Limited 11 St James's Square Kent, BR3 2YU Beckenham 11 St James's Square Chief Executive Officer Oxford Science Park Chairman Kent Chief Operating Officer Kent BR3 2YU Oxford BR3 2YU OX4 4GA Manchester Manchester M2 3WH M2 3WH REGISTRAR REGISTRAR Capita Registrars Capita Registrars The Registry Shipleys LLP FINANCIAL ADVISER AUDITOR 10 Orange Street WH Ireland Limited The Registry 34 Beckenham Road WH Ireland Limited 11 St James's Square Shipleys LLP Haymarket 34 Beckenham Road Beckenham Manchester 11 St James's Square 10 Orange Street Beckenham Kent Kent BR3 2YU BR3 2YU London M2 3WH Manchester Haymarket WC2H 7DQ M2 3WH London WC2H 7DQ NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER FINANCIAL ADVISER REGISTRAR BANKER WH Ireland Limited WH Ireland Limited 11 St James's Square Capita Registrars 11 St James's Square Manchester The Registry Manchester M2 3WH M2 3WH 3 3 Kent 3 34 Beckenham Road Woollen Hall Beckenham Castle Way BR3 2YU Southampton National Westminster Bank Plc 3 5 3 3 3 SO14 2DE NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER SOLICITOR WH Ireland Limited 11 St James's Square Taylor Vinters LLP Manchester Merlin Place, M2 3WH Milton Road, Cambridge CB4 0DP NOMINATED ADVISOR, BROKER AND BR3 2YU AUDITOR NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER REGISTRAR Chairman Chief Executive Officer Chief Operating Officer Capita Registrars The Registry 34 Beckenham Road Beckenham Kent BR3 2YU NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER WH Ireland Limited 11 St James's Square Manchester M2 3WH Merlin Place, Milton Road, SO14 2DE Milton Road, Cambridge SOLICITOR Cambridge CB4 0DP SOLICITOR 11 St James's Square Manchester CB4 0DP National Westminster Bank Plc Cambridge CB4 0DP 3 3 3 Southampton 3 Manchester M2 3WH Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Woollen Hall 11 St James's Square SO14 2DE Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Castle Way Manchester M2 3WH CB4 0DP 3 3 3 WH Ireland Limited CB4 0DP 3 Taylor Vinters LLP Kingdom. 3 3 3 Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Taylor Vinters LLP Merlin Place, Kingdom. SO14 2DE Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Taylor Vinters LLP Merlin Place, Milton Road, Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. SOLICITOR Southampton Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United SOLICITOR M2 3WH Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. 5 3 3 3 Kingdom. 3 3 3 3 Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. Milton Road, Cambridge Cambridge CB4 0DP CB4 0DP Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. 3 3 3 3 Merlin Place, Milton Road, Cambridge CB4 0DP 3 3 Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. Kingdom. Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United 3 3 5 3 3 3 3 3 Taylor Vinters LLP Merlin Place, Milton Road, Cambridge CB4 0DP Kingdom. 3 3 3 3 3 3 Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Kingdom. Kingdom. National Westminster Bank Plc Woollen Hall Castle Way Taylor Vinters LLP Taylor Vinters LLP Taylor Vinters LLP Merlin Place, Merlin Place, Merlin Place, Bircham Dyson Bell LLP Milton Road, Milton Road, Milton Road, Cambridge CB4 0DP Capita Registrars The Registry 34 Beckenham Road Beckenham Kent BR3 2YU Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Physiomics Plc is a limited liability company incorporated in England & Wales and domiciled in United Technology Development NOMINATED ADVISOR, BROKER AND NOMINATED ADVISOR, BROKER AND FINANCIAL ADVISER Taylor Vinters LLP Taylor Vinters LLP BANKER BANKER BANKER SOLICITOR BANKER 3 Chairman’s Statement Summary of results in the year ended 30 June 2014 • The turnover of the Company increased by 12% to £267,903 (2013: £240,000). • The operating loss reduced by 15% to £465,265 (2013: £548,342). • On 30 June 2014 the surplus of shareholders’ funds was £136,487 (2013: £255,821). This year, Physiomics has made good progress advancing Virtual Tumour Clinical and has broadened its offering into the personalised medicine market. In summary we have • Delivered two case studies validating Virtual Tumour Clinical, partially funded by a Technology Strategy Board Biomedical Catalyst grant. • Won further pre-clinical projects from our existing large pharma customer base. • Identifi ed potential Virtual Tumour Clinical projects to follow-on from this pre-clinical work. • Signed a deal with a speciality pharma company to determine the mechanism of action or one of their candidates. • Gained our fi rst large pharma customer for our cardiotoxicity platform. Launched a web- based portal “EasyAP™” to provide access to literature models of cardiotoxicity. • Continued discussions with relevant partners around increasing the scope of the business by way of M&A. • Initiated a new project with a large pharma client to develop an immunomodulatory module for Virtual Tumour. Immunomodulatory agents are being pursued by several large pharmas following the clinical success of agents targeting PD-1 and CTLA-4. • Signed a heads of terms agreement with Diatech Pharmacogenomics to enter the personalised medicine fi eld, initially in Italy. • Initiated discussions with a large software provider to determine if part or all of Virtual Tumour could be sold as part of their offering. Dr Paul Harper, Non-Executive Chairman 5 Chairman and Chief Executive Officer’s Statement Introduction During the period Physiomics successfully applied Virtual Tumour to clinical predictions for the first time. This was an important step forward for a number of reasons: Firstly, there was a large degree of direct interest from customers and potential customers for this service. Secondly, the unmet need for better clinical dosing schedules is driven by the need to accelerate development programmes, reduce costs and bring forward potential revenues by designing clinical protocols that are already optimised for patient dosing. Typically the current most commonly used method for determining the clinical regimen is to increase the dosage of the most effective regimen from animal studies to human scale. Animal models often poorly reflect the situation in a human patient due to for example disparities in relative sizes, physiology and pharmacokinetics, parameters that are all fundamental to drug efficacy. The approximations generated through this approach, when used to design a clinical study, can contribute to the failure of a clinical trial. Thirdly the cost of failure in the clinical setting vastly outweighs that in the pre-clinical setting. Given the high cost and the subsequent consequences arising from a failed clinical trial, if customers can be shown (through pilot projects) that a predictive technology is able to improve the chances of clinical success, then they are likely to progressively adopt the new paradigm. Drug development has for so long relied almost exclusively on extrapolating data from studies in animal models to direct dosing in patients that embracing a new ‘black box’ based technology approach is a major policy change, despite the fact that adoption of system modelling is being encouraged by FDA and similar agencies. The predictive power of Virtual Tumour Clinical has been demonstrated in two different indications so far. Initial marketing of the results to large pharmaceutical companies has led to a positive expression of interest. There has also been a desire to see how the technology performs across a number of further indications. Therefore it is the intention of the Company to perform further validation studies in other types of cancer, in addition to initiating collaborations with large pharma companies. Discussions with collaborators to set up such case studies are well advanced. Relationships with our existing large pharma customer base were strengthened in the period with a number of new pre-clinical projects. These projects have the potential to be extended into the first large pharma Virtual Tumour Clinical projects in due course. 6 Chairman and Chief Executive Officer’s Statement - continued The Company’s activities in the cardiotoxicity arena have gathered pace. Early stage drug candidates are now routinely screened for cardiotoxic effects, as required by the regulatory authorities. In particular, all candidate drugs must be screened for activity against the hERG potassium channel. However, such screening is time-consuming and costly. It is also known that a large number of candidates are incorrectly progressed or discarded based on hERG activity alone. Physiomics’ in silico platform takes into account activity against hERG and two additional ion channels to deliver better predictions of action potential time courses and duration based on several literature models. In silico prediction of cardiotoxic side effects is therefore a more effective way of helping to select which candidates to progress. In addition to Physiomics’ cardiotoxicity simulation service, we have now launched our web-based EasyAP™ application. EasyAP™ allows access to the service to a broad range of customers, by allowing customers to run simulations on their own computers on a pay-per-compound or annual subscription basis. Physiomics gained its first large pharma customer for cardiotoxicity prediction in the period and the directors hope that this new platform will attract further customers. A heads of terms agreement with Diatech Pharmacogenomics was signed in the period. If translated into a full agreement, this collaboration would provide Physiomics with access to the majority of clinical centres in Italy and also an opportunity to develop personalised medicine models. When combined with Physiomics’ Virtual Tumour, which provides information on how much drug to give and when to give it, we believe it will provide an industry-leading platform to support oncology clinical trials worldwide. The search for an appropriate M&A partner to further build Physiomics and provide the best outcome for shareholders has continued in the period and significant discussions have taken place. Finally, after the period ended Physiomics gained its first large pharma project to model immunomodulatory agents using Virtual Tumour. Immunomodulatory, or ‘immune therapy’ agents have been described as an extremely hot topic in the oncology field at present. A number of high profile clinical trials are ongoing and several large pharma companies are entering the field for the first time. The directors believe that, if the project is successful, this will lead to further interest in Virtual Tumour from other large pharma companies who are active in this area. 7 Chairman and Chief Executive Officer’s Statement - continued Technology development (i) Virtual Tumour product improvements The immune system can play a significant role in the course of a cancer. While in some cases the immune system does not seem to recognise and attack a tumour, in many other patients the cells of the immune system are recruited to the vicinity of the tumour, but fail to kill enough cancer cells to be really effective. Over the last few years a number of drug candidates have emerged aimed at activating the latent immune response to a tumour or removing a ‘brake’ on the immune response created by the cancer itself. Several large pharmaceutical companies have targeted this response, with some notable successes in the clinic. Given this burgeoning interest from our primary customer base, Physiomics started to develop an immune system module to work in tandem with Virtual Tumour, to model the effects of these agents. It became clear that one pharma partner in particular was very keen to develop such a model and so our first commercial project in this area was initiated in September 2014. This project should provide all the data required to develop a functional model which could be sold on to other potential customers. (ii) Virtual Tumour Clinical Two critical case studies were completed in the period, allowing us to develop, test and validate Virtual Tumour Clinical for the first time. The first study related to prostate cancer and the data came from the National Institutes of Health (NIH) in the USA. This study allowed us to determine which of the key parameters of the model needed to be modified in order to make accurate clinical predictions. The second project, in collaboration with Oxford University, was a blind validation study in melanoma. Here we showed that we could make accurate predictions of the outcome of combination therapies in a clinical trial. This was achieved by priming Virtual Tumour with key human data and gaining a deep understanding of the relevant tumour growth rates from the literature. Both case studies were extremely encouraging, demonstrating that the basic architecture of the existing pre-clinical Virtual Tumour could be translated into a clinical setting with the appropriate modifications. The melanoma case study was supported by a Technology Strategy Board Biomedical Catalyst grant award. (iii) Cardiac toxicity prediction service During the period Physiomics gained its first large pharma customer for cardiotoxicity prediction. Feedback obtained during the project and from other potential customers suggested that, in addition to predicting the overall risk of cardiac side effects, customers may also like to predict the outcome of scientific experiments that provide the direct effect of a candidate on a particular ion channel on a particular cell line, which may also provide an useful insight into cardiac toxicity risk. The regulatory agencies are also taking a keen interest in such predictions. For this reason we extended the scope of our cardiotoxicity predictions to include literature models which predict ‘action potentials’ on cell lines, in our web-based EasyAP™ platform, which was launched recently. 8 Chairman and Chief Executive Officer’s Statement - continued Outlook The landscape of the pharmaceutical sector remains mixed, with a number of notable companies downsizing and closing key sites. The failed Pfizer bid for Astra Zeneca and the Abbvie bid for Shire, interfered with the decision making processes in each of the companies, shelving or at least delaying any significant plans. Events that have an impact on decision making have occurred throughout the Industry, slowing the pace of development and deferring the need for third party services. Fortunately oncology remains an important indication in those companies that have programmes. Certain key pharma clients have made significant pipeline and resource decisions, most notably focusing efforts on immunomodulatory agents for the treatment of cancers. Physiomics has aligned itself with this trend and the Directors are confident that this will allow us to engage with new customers. We believe the interest displayed in Virtual Tumour Clinical has vindicated our strategy to develop further the technology into the clinical arena and large pharma collaborations are also expected in this regard. The pipeline of potential opportunities is the strongest that we have seen in recent years. In addition the Company has the opportunity to extend the scope of its predictive technology for oncology through its collaboration with Diatech Pharmacogenomics. Initially focusing on the delivery of already marketed drugs to patients, the work could be extended in future to help support decisions on appropriate patient populations for clinical trials. Finally interest from large software providers in the Virtual Tumour platform, the launch of our first web-based models and the continued search for the right M&A deal suggest that the next period will be an exciting one in the development of Physiomics. Dr Paul Harper, Non-Executive Chairman Dr Mark Chadwick, Chief Executive Officer 9 Chairman and Chief Executive Officer’s Statement - continued Our strategy Physiomics has evolved a strategy that combines lower risk service activities which support the development of client drugs with a risk sharing approach to gain a share in the development of novel drugs in development. This is coupled with development of new models to extend our predictive skills from pre-clinical development, through clinical development to treatment of patients. We have also added ancillary modelling activities to look at the cardiotoxicity and pharmacokinetic profile of new drugs in man in a bid to provide a more comprehensive support package for client companies. These can be summarised as follows: • Modelling in oncology o Virtual Tumour • to direct and optimise candidate selection o Virtual Tumour Clinical • to optimise the design of clinical trials • provide a rationale for dosing of drug combinations • Customised medicine o New model development to forecast the optimal drug regimen for treatment of patients on an individual basis o DrugCard database to help identify successful drug regimens in particular cancer types • Drug molecule parameters o Models to predict potential cardiotoxicity as an aid to optimisation of drug design and selection of viable candidate compounds o Options to evaluate cardiotoxicity using simple on-line models through to in depth evaluation using more complex models thereby providing cost effective predictions matched to different stages of the drug discovery and optimisation process. o Models capable of forecasting the pharmacokinetic profile of a new drug molecule We generate revenues from these activities. However, we will also adopt a risk sharing model where the fee is satisfied by part ownership of a novel drug in development. There are already two examples of this approach. As an extension of our strategy to risk share, we have an active programme to identify compounds that can be in-licensed and developed by Physiomics or through a joint ownership collaboration. 10 Strategic Report Business review The Company is principally engaged in providing services to pharmaceutical companies in the areas of outsourced systems and computational biology. • The turnover of the Company increased to £267,903 (2013: £240,000) • The operating loss was £465,265 (2013 £548,342) • At the 30 June 2014 the surplus of shareholders’ funds was £136,487 (2013: £255,821) Strategic and financial performance indicators The Company is focused on the creation of long-term value for its shareholders. The directors consider that the key performance indicators are those that communicate the financial performance and strength of the Company as a whole, these being revenue, profitability and shareholders’ funds. The Company faces many risks on the way to building shareholder value. The process of winning major contracts in a competitive environment is rarely simple and can be delayed for reasons outside the Company’s control. This means the Company faces major uncertainties in its cash flow. Addressing the risks The board addresses the financial uncertainties by careful budget monitoring and by quickly responding to variations. If there are delays in signing contracts then recruitment and capital expenditure is frozen until the anticipated income is achieved. Interest rate risk The Company finances its operations by cash and short term deposits. The Company’s policy on interest rate management is agreed at board level and is reviewed on an ongoing basis. Other creditors, accruals and deferred income values do not bear interest. Interest rate profile The Company had no bank borrowings at the 30 June 2014. Liquidity risk The Company seeks to manage financial risk by ensuring that sufficient liquidity is available to meet foreseeable needs and to invest cash assets safely and profitably. Fair values Fair values of financial instruments equate to the best value as disclosed in the financial information. There are no material differences between the fair value of financial instruments and the amount at which they are stated in the financial statements. 11 Strategic Report - continued Regulatory risk There is a risk that the business model is impacted by future changes in regulations in the medical and pharmaceutical industry. Major agencies such as the FDA are actively promoting the use of system modelling and issue advisory papers which set out their thinking. The Company regularly reviews activity in this area through proactive discussions with key industry officials, professional advisors and regulatory bodies where appropriate. The Company’s customers are predominately pharmaceutical companies who market and sell outsourced systems and computational biology to their customers on a worldwide basis. Skills risk The success and future growth of the Company is in part dependent on the continued performance and delivery of certain directors, managers and key staff. The Company seeks to recruit, develop, and manage talent at the highest levels in order to meet the continuing demand for innovative and leading edge developments in specialised modelling solutions within the pharmaceutical industry. The ability of the Company to attract and retain highly skilled employees requires the Company to offer and maintain competitive employment packages and personal development opportunities. It is considered essential to implement a system of succession planning processes to ensure key roles are identified and career development opportunities established. The Company therefore invests in the recruitment of highly skilled individuals and operates a proactive system of training and performance management across the business. The Company has built a network of contracted specialists who can contribute a unique combination of skills as required. Systems & infrastructure The Company is dependent on its IT technical infrastructure and systems for the management of its core operations and research and development programmes. Risks of system outages, loss of connectivity and impact on data integrity are regularly reviewed and a business continuity plan has been established for the effective management of unforeseen disruption to the business. Continuity of access to data and integrity of data is maintained through the implementation of a rigorous system of data storage, backup and monitoring of key coding and modelling data. By order of the board Dr Paul Harper Chairman 18 November 2014 12 Directors’ Report The directors submit their report and the audited financial statements of Physiomics Plc for the year ended 30 June 2014. Results There was a loss for the year after taxation amounting to £425,621 (2013 loss: £500,571). In view of accumulated losses, and given the stage of the Company’s development, the directors are unable to recommend the payment of a dividend. Statement of directors’ responsibilities The directors are responsible for preparing the Annual Report and the financial statements in accordance with applicable law and regulations. UK company law requires the directors to prepare financial statements for the Company in accordance with International Financial Reporting Standards (“IFRS”) as adopted by the EU. Company law requires the directors to prepare such financial statements in accordance with IFRS, the Companies Act 2006 and Article 4 of the IAS Regulation. The financial statements are required by law, and IFRS as adopted by the EU, to give a true and fair view of the state of affairs of the Company. In preparing the Company financial statements, the directors are required to: a. select suitable accounting policies and then apply them consistently; b. make judgements and estimates that are reasonable and prudent; c. state whether they have been prepared in accordance with IFRS as adopted by the EU; d. prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Company will continue in business. The directors are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time the financial position of the Company and to enable them to ensure that the financial statements comply with the requirements of the Companies Act 2006. They are also responsible for safeguarding the assets of the Company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. The directors are also responsible for the maintenance and integrity of the Physiomics Plc website. 13 Directors’ Report - continued Substantial shareholdings The Company has been informed that on 30 June 2014 the following shareholders held substantial holdings in the issued ordinary shares of the Company. Number of Ordinary shares Holding % Barclayshare Nominees Limited* TD Direct Investing Nominees (Europe) Limited HSDL Nominees Limited Hargreaves Lansdown (Nominees) Limited LR Nominees Limited HSBC Client Holdings Nominee (UK) Limited Dr Paul Harper * Includes shares 70,750,000 held by Mr Peter Hoskins representing a holding of 4.1% 375,592,781 309,996,909 276,830,252 126,511,489 50,383,597 79,780,603 52,570,787 21.8% 18.0% 16.1% 7.4% 3.3% 4.6% 3.1% No other person has reported an interest of more than 3% in the ordinary shares. On 30 June 2014 Dr Mark Chadwick held 3,970,151 ordinary shares and Dr Christophe Chassagnole held 15,189,740 ordinary shares. The holding percentages were 0.23% and 0.89% respectively. Directors’ remuneration Details of directors’ remuneration in the year ended 30 June 2014 is set out below: Dr P B Harper Dr M P Chadwick Dr C D Chassagnole Emoluments £ 35,000 108,570 58,532 Benefi ts Pension contributions £ £ Total £ - 1,137 1,193 - - 35,000 109,707 3,030 62,755 Total 202,102 2,330 3,030 207,462 Company Secretary On 7 July 2014 Roger Jones resigned as Company Secretary and Elizabeth King was appointed. 14 Directors’ Report - continued Post balance sheet events On 23 July 2014, the Company entered into an Equity Swap Agreement with YA Global Master SPV Ltd (“Yorkville”) under which Yorkville agreed to subscribe for 312,500,000 ordinary shares of 0.04p at a subscription price of £0.18p per share. As part of this agreement the Company paid £289,688 as a swap payment to Yorkville on 31 July 2014. In consideration for this payment the Company will receive 15 monthly payments between the date of admission to trading on AIM and 1 November 2015 the amounts of which will vary depending on the average weighted price of the ordinary shares in the preceding 10 days prior to the payment falling due. Statement as to disclosure of information to auditors The directors in office on 18 November 2014 have confirmed that, as far as they are aware, there is no relevant audit information of which the auditors are unaware. Each of the directors have confirmed that they have taken all the steps that they ought to have taken as directors in order to make themselves aware of any relevant audit information and to establish that it has been communicated to the auditors. Corporate governance The Board of directors is accountable to the Company’s shareholders for good corporate governance. The Company takes corporate governance seriously and the statement below sets out how the board apply the principles of good corporate governance. Directors The Company supports the concept of an effective board leading and controlling the Company. The board is responsible for formulating and approving the strategy of the business and meets at least six times per year. Various matters are specifically reserved for board decision, ensuring that the board maintains full control over strategic, financial, organisational, risk and compliance issues. Management supply the board with appropriate and timely information, while the directors are encouraged to seek any further information they consider necessary. The board comprises two executive directors, who fulfil the main operational roles in the Company, and a non-executive Chairman. Due to the size of the Company, the board does not consider the appointment of a senior non-executive director to be necessary. A full list of the directors is shown above. Accountability The board endeavours to present a balanced and comprehensible assessment of the Company’s situation and prospects in all of its published statements, including interim reports, price-sensitive announcements, reports to regulators and information supplied to comply with statutory requirements. The Audit Committee consists of Christophe Chassagnole and Elizabeth King and is chaired by Dr Paul Harper. The committee meets at least three times per year to consider matters relating to the Company’s financial position and financial reporting. The Audit Committee reviews the independence and objectivity of the external auditors, as well as the amount of non-audit work undertaken by Shipleys LLP to satisfy the Committee that this will not compromise their independence. Details of the fees paid to Shipleys LLP during the current accounting period are given in note 3 to the accounts. There are no areas of work where Shipleys LLP are prohibited from carrying out work. 15 Directors’ Report - continued Remuneration Committee The Remuneration Committee has been established primarily to determine the remuneration, terms and conditions of employment of the executive directors of the Company. The Committee comprises Dr Mark Chadwick and Elizabeth King and is chaired by Dr Paul Harper. It meets at least twice a year. The primary concern of the Committee is to establish a system of rewards and incentives that aim to align the interests of the executive directors with the long-term interests of the share-holders. These are based on the achievement of both scientific and commercial milestones while taking no account the financial position of the Company at this stage in its development. Any remuneration issues concerning non-executive directors are resolved by this Committee and no director participates in decisions that concern his own remuneration. Going Concern After making appropriate enquiries, the directors have a reasonable expectation that the Company will safeguard the Company’s assets. The risk management process and internal control systems are designed to manage rather than eliminate the risk of failing to achieve business objectives and can only provide reasonable, but not absolute, assurance against material misstatement or loss. The key features of the Company’s system of internal control are as follows: • a clearly defined organisational structure and set of objectives. • the executive directors play a significant role in the day to day operation of the business. • detailed monthly management accounts are produced by an independent third party for the board to review and take appropriate action. Internal Control The Company values the views of its shareholders and recognises their interest in the Company’s strategy, performance and the ability of the board. The AGM provides an opportunity for two-way communication and all shareholders are encouraged to attend and participate. Separate resolutions will be put to shareholders at the AGM, giving them the opportunity to discuss matters of interest. The Company counts all proxy votes and will indicate the level of proxies lodged on each resolution, after each has been dealt with on a show of hands. The Company uses its website www.physiomics-plc.com as another means of providing information to shareholders and other interested parties. The website displays the annual report and accounts, interim results and other relevant announcements. Annual General Meeting The Annual General Meeting of the Company will be held at the offices of Taylor Vinters LLP, Tower 42, 33rd Floor, 25 Old Broad Street, London, EC2N 1HQ at 11.00 am on 15 December 2014. By order of the board Dr Paul Harper Chairman 18 November 2014 16 Independent Auditors Report to the shareholders of Physiomics Plc We have audited the financial statements of Physiomics Plc for the year ended 30 June 2014 which comprise the income statement, the statement of financial position, the cash flow statement, the statement of changes in equity and the related notes. The financial reporting framework that has been applied in the preparation of the financial statements is applicable law and International Financial Reporting Standards (IFRSs) as adopted by the European Union. This report is made solely to the Company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the Company’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Company and the Company’s members as a body, for our audit work, for this report, or for the opinions we have formed. Respective responsibilities of directors and auditors As explained more fully in the statement of directors’ responsibilities, the directors are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view. Our responsibility is to audit the financial statements in accordance with applicable law and International Standards on Auditing (UK and Ireland). Those standards require us to comply with the Auditing Practices Board’s (APB’s) Ethical Standards for Auditors. Scope of the audit of the financial statements An audit involves obtaining evidence about the amounts and disclosures in the financial statements sufficient to give reasonable assurance that the financial statements are free from material misstatement, whether caused by fraud or error. This includes an assessment of: whether the accounting policies are appropriate to the Company’s circumstances and have been consistently applied and adequately disclosed; the reasonableness of significant accounting estimates made by the directors; and the overall presentation of the financial statements. Opinion on financial statements In our opinion: • the financial statements give a true and fair view of the state of the Company’s affairs as at 30 June 2014 and of its loss for the year then ended; • the financial statements have been properly prepared in accordance with IFRSs as adopted by the European Union; • the financial statements have been prepared in accordance with the requirements of the Companies Act 2006. 17 Independent Auditor’s Report to the shareholders of Physiomics Plc – continued Opinion on other matters prescribed by the Companies Act 2006 In our opinion the information given in the directors’ report for the financial year for which the financial statements are prepared is consistent with the financial statements. Matters on which we are required to report by exception We have nothing to report in respect of the following matters where the Companies Act 2006 requires us to report to you if, in our opinion: • adequate accounting records have not been kept by the Company, or returns adequate for our audit have not been received from branches not visited by us; or • the financial statements are not in agreement with the accounting records and returns; or • certain disclosures of directors’ remuneration specified by law and not made; or • we have not received all the information and explanations we require for our audit. Benjamin Bidnell (senior statutory auditor) For and on behalf of Shipleys LLP statutory auditor 10 Orange Street Haymarket London WC2H 7DQ 18 November 2014 18 Income Statement for the year ended 30 June 2014 Revenue 2 267,903 240,000 Year ended Year ended Notes 30-Jun-14 30-Jun-13 £ £ Net operating expenses Share-based compensation Operating loss Finance income Finance costs (733,168) - (776,520) (11,822) (465,265) (548,342) 1,013 - 4,551 - 3 4 5 Loss before taxation (464,252) (543,791) UK corporation tax 7 38,631 43,220 Loss for the year attributable to equity shareholders (425,621) (500,571) Loss per share (pence) Basic and diluted 8 (0.026) p (0.033) p 19 Statement of fi nancial position as at 30 June 2014 Company Number: 4225086 Year ended Year ended Notes 30-Jun-14 30-Jun-13 £ £ 10 11 12 9 11,669 3,589 1 15,259 96,576 132,358 16,336 4,250 1 20,587 180,717 179,162 228,934 359,879 244,193 380,466 Non-current assets Intangible assets Property, plant and equipment Investments Current assets Trade and other receivables Cash and cash equivalents Total assets Current liabilities Trade and other payables 9,12 (107,706) (124,645) Total liabilities Net assets Capital and reserves Share capital Capital reserves Retained earnings (107,706) (124,645) 136,487 255,821 14 15 16 687,663 4,017,602 602,620 3,796,358 (4,568,778) (4,143,157) Equity shareholders’ funds 136,487 255,821 The fi nancial statements were approved by the Board of Directors and authorised for issue on 18 November 2014 and are signed on its behalf by: Dr Paul Harper Chairman 20 Statement of changes in equity for the year ended 30 June 2014 Share Share-based Total Share premium compensation Retained shareholders’ capital account reserve earnings £ £ £ £ funds £ At 1 July 2012 599,420 3,697,169 80,567 (3,642,586) 734,570 Share issue (net of costs) 3,200 6,800 Loss for the year Share-based compensation - - - - - - - 10,000 (500,571) (500,571) 11,822 - 11,822 At 30 June 2013 602,620 3,703,969 92,389 (4,143,157) 255,821 Share issue (net of costs) 85,043 221,244 306,287 Share-based compensation - - - - - - - - 306,287 (425,621) (425,621) - - At 30 June 2014 687,663 3,925,213 92,389 (4,568,778) 136,487 21 Cash Flow Statement for the year ended 30 June 2014 Cash fl ows from operating activities: Operating loss Amortisation and depreciation Share-based compensation (Decrease) increase in receivables Decrease in payables Year ended 30-Jun-14 £ Year ended 30-Jun-13 £ (465,265) (548,342) 7,925 - 85,833 (16,939) 8,540 11,822 (47,994) 19,114 Cash generated from operations (388,446) (556,860) UK corporation tax received Interest paid 36,939 - 32,373 - Net cash generated from operating activities (351,507) (524,487) Cash fl ows from investing activities: Interest received Purchase of non-current assets, net of grants received Net cash received by investing activities 1,013 (2,597) (1,584) 4,551 (1,852) 2,699 Cash outfl ow before fi nancing (353,091) (521,788) Cash fl ows from fi nancing activities: Issue of ordinary share capital (net of expenses) Net cash from fi nancing activities 306,287 306,287 10,000 10,000 Net decrease cash and cash equivalents (46,804) (511,788) Cash and cash equivalents at beginning of year 179,162 690,950 Cash and cash equivalents at end of year 132,358 179,162 22 Notes on the Financial Statements Basis of preparation Physiomics Plc has adopted International Financial Reporting Standards (“IFRS”), IFRIC interpretations and the Companies Act 2006 as applicable to companies reporting under IFRS. The financial statements have been prepared on the historical cost basis. The significant accounting policies are set out below. Accounting policies Revenue recognition The revenue shown in the income statement relates to amounts received or receivable from the provision of outsourced systems and computational biology services to pharmaceutical companies. Revenue from the provision of its principal activities are recognised when the Company has transferred to the buyer the significant risks and rewards of ownership, has no continuing managerial involvement or control to the degree normally associated with ownership and can reliably measure the economic benefits of the transaction. Segment reporting A business segment is a group of assets and operations engaged in providing products or services that are subject to risks and returns that are different from those of other business segments. A geographical segment is engaged in providing products or services within a particular economic environment that are subject to risks and return that are different from those of segments operating in other economic environments. Going concern The accounts have been prepared on the going concern basis. The Company primarily operates in the relatively defensive pharmaceutical industry which we expect to be less affected by current economic conditions compared to other industries. The Company had £132,358 of cash and cash equivalents as at 30 June 2014 (2013: £179,162). The Board operates an investment policy under which the primary objective is to invest in low-risk cash or cash equivalent investments to safeguard the principal. The Company’s forecasts, taking into account likely revenue streams, show that the Company has sufficient funds to operate for the foreseeable future. After reviewing the Company’s forecasts, the directors believe that the Company is adequately placed to manage its business and financing risks successfully despite the current uncertain economic outlook. Accordingly, they continue to adopt the going concern basis in preparing the annual report and accounts. Intangible assets Intangible assets acquired separately from third parties are recognised as assets and measured at cost. Following initial recognition, intangible assets are measured at cost or fair value at the date of acquisition less any amortisation and any impairment losses. Amortisation costs are included within the net operating expenses disclosed in the income statement. 23 Notes on the Financial Statements - continued Intangible assets are amortised over their useful lives as follows: Useful Life Method Software 15 years Straight line Useful lives are also examined on an annual basis and adjustments, where applicable are made on a prospective basis. The Company does not have any intangible assets with indefinite lives. Property, plant and equipment All items are initially recorded at cost. Impairment of assets Property, plant and equipment and intangible assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is recognised for the amount by which the asset’s carrying amount exceeds its recoverable amount. The recoverable amount is the higher of an asset’s fair value less costs to sell and value in use. For purposes of assessing impairment, assets that do not individually generate cash flows are assessed as part of the cash generating unit to which they belong. Cash generating units are the lowest levels for which there are cash flows that are largely independent of the cash flows from other assets or groups of assets. Depreciation Depreciation is calculated to write off the cost of an asset over its useful economic life as follows: Leasehold improvements - the remaining life of the lease Fixtures and computers - three years, straight-line basis Research and development expenditure Expenditure on research activity is recognised as an expense in the period in which it is incurred. Trade and other receivables Trade receivables are recognised and carried at the lower of their original invoiced value and recoverable amount. Balances are written off when the probability of recovery is considered to be remote. Financial liability and equity Financial liabilities and equity instruments are classified according to the substance of the contractual arrangements entered into. An equity instrument is any contract that evidences a residual interest in the assets of the Company after deducting all of its liabilities. Cash and cash equivalents Cash and cash equivalents in the statement of financial position comprise cash at bank and in hand and short-term deposits with an original maturity of three months or less. 24 Notes on the Financial Statements - continued Foreign currency Assets and liabilities denominated in foreign currencies are translated into sterling at the rates of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into sterling at the rate of exchange ruling at the date of the transaction. Exchange differences are taken into account in arriving at the operating result. Leased assets and obligations Where assets are financed by leasing agreements that give rights approximating to ownership (“finance leases”), the assets are treated as if they had been purchased outright. The amount capitalised is the present value of the minimum lease payments payable during the lease terms. The corresponding leasing commitments are shown as obligations to the lessor. Lease payments are treated as consisting of capital and interest elements, and the interest is charged to the profit and loss in proportion to the remaining balance outstanding. All other leases are ‘operating leases’ and the annual rentals are charged to the income statement on a straight-line basis over the lease term. Government Grants Deferred government grants in respect of capital expenditure are treated as deferred income and are credited to the income statement over the estimated useful life of the assets to which they relate. Government grants of a revenue nature are credited to the profit and loss account in the same period as the related expenditure. Share based payments The Company issues equity settled share based payments to certain employees. Equity settled share based payments are measured at fair value at the date of grant. The fair value determined at the grant date is expensed on a straight-line basis over an estimated vesting period. Fair value is measured by use of a binomial model. Investments Participating interests are stated at cost less amounts written off in the Company balance sheet. Taxation Tax currently payable is based on the taxable profit for the period which may differ from net profit reported in the income statement. Deferred taxation is recognised in respect of all timing differences that have originated but not reversed at the balance sheet date where transactions or events have occurred at that date that will result in an obligation to pay further tax, or a right to pay less tax in future. Timing differences are differences between the Company’s taxable profits and its results as stated in the financial statements that arise from the gains or losses in tax assessments in period different from those in which they are recognised in the financial statements. Deferred tax assets are recognised only to the extent that the directors consider that it is more likely than not that there will be sufficient taxable profits from which the future reversal of the underlying timing differences can be deducted. Deferred tax is measured at the average tax rates that are expected to apply in the periods in which the timing differences are expected to reverse. 25 Notes on the Financial Statements - continued Adoption of international accounting standards The following new and revised Standards and Interpretations have been adopted in the current financial year as issued by the International Accounting Standards Board (IASB) and the International Financial Reporting Interpretations Committee (IFRIC): IAS 12 Amendment - Deferred Tax: Recovery of Underlying Assets IAS 19 (revised) – Employee Benefits IAS 27 (revised 2011) - Separate Financial Statements IFRS 7 Disclosures – Offsetting Financial Assets and Financial Liabilities IFRS 9 – Financial Instruments (issued 2010) IFRS 11 - Joint Arrangements IFRS 12 - Disclosures of Interest in Other Entities IFRS 13 - Fair Value Measurement Adoption of these Standards and Interpretations did not have any effect on the financial statements of the Company, or result in changes in accounting policy or additional disclosure. The IASB and IFRIC have issued a number of Standards and Interpretations with an effective date after the date of these financial statements. The new Standards and Interpretations issued include: IFRS 1 (amended) Government Loans IFRS 10 Consolidated Financial Statements; Investment Entities IAS 1 (amended) Presentation of Items of Other Comprehensive Income IAS 28 (revised) Investments in Associates and Joint Ventures IAS 32 (amended) Offsetting Financial Assets and Financial Liabilities The Directors anticipate that the adoption of these Standards and Interpretations in future periods will have no material impact on the Company’s financial statements. 26 Notes on the Financial Statements - continued 1 CRITICAL ACCOUNTING ESTIMATES AND AREAS OF JUDGEMENT There were no material accounting estimates or areas of judgements required. 2 REVENUE AND SEGMENTAL REPORTING The principal activities are the provision of outsourced systems and computational biology services to pharmaceutical companies. This activity comprises a single segment of operation of a sole UK base and entirely UK based assets. Revenue was derived in the UK, USA and European Union from its principal activity. 3 OPERATING LOSS Operating loss is stated after charging Research and development Current year expenditure Depreciation charge for the year - Owned assets Amortisation charge for the year Audit services, refer to below Amounts payable for both audit and non-audit services Audit services – Statutory audit Tax services – Compliance services Shipleys LLP Shipleys LLP 10,000 2,000 3,258 4,667 12,000 2014 £ Payable to: 2014 £ 2013 £ 259,918 186,486 3,829 4,711 12,000 2013 £ 10,000 2,000 12,000 12,000 27 Notes on the Financial Statements - continued 4 FINANCE INCOME Bank interest receivable 5 FINANCE COSTS Interest payable 6 STAFF COSTS Staff costs during the year Wages and salaries Social security costs Pension costs 2014 £ 1,013 2014 £ - 2014 £ 154,006 14,939 - 168,945 2013 £ 4,551 2013 £ - 2013 £ 147,995 16,086 - 164,081 Average number of employees 5 4 Details of the remuneration of directors are included in the Directors’ report on page 14. 28 Notes on the Financial Statements - continued 7 TAXATION (a) Analysis of charge in the year Research and Development tax credit: current year Research and Development tax credit: prior year Total current tax (b) Factors affecting current tax charge 2014 £ 45,000 (6,369) 38,631 2013 £ 43,308 (88) 43,220 The tax assessed for the period is lower than the standard rate of corporation tax in the UK. The timing differences are explained below: 2014 £ 2013 £ Loss on ordinary activities before taxation (464,252) (543,791) Tax on loss on ordinary activities at standard corporation tax rate of 20% (2013: 20%) (92,850) (108,758) Expenses not deductible for tax purposes Capital allowances (in excess of) less than depreciation Unrelieved tax losses and other deductions arising in the year Research and Development tax credit: current and prior year Total current tax - (152) 54,371 38,631 38,631 480 687 107,591 43,220 43,220 At 30 June 2014 tax losses of approximately £3,170,000 (2013: £2,851,000) remained available to carry forward against future taxable trading profi ts. 8 EARNINGS PER SHARE The calculations of loss per share are based on the following losses and numbers of shares. 2014 £ 2013 £ Loss on ordinary activities after tax (425,621) (500,571) Weighted average no of shares: For basic and diluted loss per share No. No. 1,666,241,670 1,502,013,088 Basic and diluted loss per share (0.026p) (0.033p) 29 Notes on the Financial Statements - continued 9 FINANCIAL INSTRUMENTS RECOGNISED IN THE STATEMENT OF FINANCIAL POSITION Held for trading 2014 £ 96,576 132,358 228,934 107,706 107,706 2013 £ 180,717 179,162 359,879 124,645 124,645 Patents, trade marks and software £ 75,646 - 75,646 59,310 4,667 63,977 11,669 16,336 Current fi nancial assets Trade and other receivables Cash and cash equivalents Current fi nancial liabilities Trade and other payables 10 INTANGIBLE FIXED ASSETS Cost At 1 July 2013 Additions At 30 June 2014 Amortisation At 1 July 2013 Provided in the year At 30 June 2014 Net book value 30 June 2014 30 June 2013 30 Notes on the Financial Statements - continued 11 PROPERTY PLANT AND EQUIPMENT Cost At 1 July 2013 Additions Disposals At 30 June 2014 Depreciation At 1 July 2013 Provided in the year Disposals At 30 June 2014 Net book value 30 June 2014 30 June 2013 12 OTHER FINANCIAL ASSETS AND LIABILITIES Trade and other receivables are as follows: Trade receivables Prepayments Other receivables Corporation tax recoverable Trade and other payables are as follows: Amounts payable relating to the purchase of goods and services Other payables Accruals 2014 £ 13,135 27,501 10,940 45,000 96,576 55,422 12,122 40,162 107,706 Fixtures and computers £ 50,433 2,597 - 53,030 46,183 3,258 - 49,441 3,589 4,250 2013 £ 98,000 28,283 11,126 43,308 180,717 56,727 26,403 41,515 124,645 31 Notes on the Financial Statements - continued 13 LOANS There were no loans with directors at 30 June 2014 and 30 June 2013. 14 SHARE CAPITAL Ordinary shares of 0.04p each 2014 Number 2013 Number Authorised: 25,000,000,000 25,000,000,000 Issued and fully paid: £ £ Balance at 1 July 2012 599,420 451,420 Issue of share capital As at 30 June 2013 Issue of share capital As at 30 June 2014 3,200 148,000 602,620 599,420 85,043 3,200 687,663 602,620 The Company has one class of ordinary shares which carry no right to fi xed income. On 30 July 2014 the Company issued 312,500,000 ordinary shares of 0.04p at a price of 0.18p per ordinary share under an Equity Swap Agreement dated 23 July 2014. 32 Notes on the Financial Statements - continued 15 CAPITAL RESERVES Share premium account £ Share-based compensation reserve £ Total £ 3,697,169 80,567 3,777,736 6 800 - - - - 11,822 6,800 - 11,822 Balance at 1 July 2012 Issue of share capital Share issue costs Share-based compensation Balance at 30 June 2013 3,703,969 92,389 3,796,358 Issue of share capital Share issue costs Share-based compensation 221,244 - - - - - 221,244 - - Balance at 30 June 2014 3,925,213 92,389 4,017,602 The share premium account consists of proceeds from the issue of shares in excess of their par value (which is included in the share capital account). The share-based compensation reserve represents the credit arising on the charge for share options calculated in accordance with IFRS 2. 16 RETAINED EARNINGS Balance at 1 July 2012 Loss for the year Balance at 30 June 2013 Loss for the year Balance at 30 June 2014 17 CAPITAL COMMITMENTS At 30 June 2013 and 30 June 2014 the Company had no capital commitments. £ (3,642,586) (500,571) (4,143,157) (425,621) (4,568,778) 33 Notes on the Financial Statements - continued 18 SHARE BASED PAYMENT TRANSACTIONS The Company operates a share option scheme under the Enterprise Management Initiative Scheme (“EMI”). The following share options have been granted over ordinary shares of 0.04p each and remain exercisable under the scheme: Certain performance conditions for EMI share options are unmet at the date of these statements. All other options are vested in full. The Company also operates an unapproved share option scheme. The following share options have been granted over ordinary shares of 0.04p each and remain exercisable under the scheme: All performance conditions for unapproved options have been met and are vested in full. The fair value of share options awarded during the previous years were determined using the Black- Scholes pricing model. In addition to the information disclosed above, the assumptions employed in the pricing model were as follows – expected volatility: 20%, expected dividends: nil, risk-free interest rate: 2% per annum. Where performance conditions are unmet a probability of success factor has been applied to such awards. 34 Notes to the Financial Statements - continued 19 FINANCIAL INSTRUMENTS The Company’s financial instruments comprise cash and short term deposits. The Company has various other financial instruments, such as trade debtors and creditors that arise directly from its operations, which have been excluded from the disclosures other than the currency disclosures. The main risks arising from the Company’s financial instruments are interest rate risk, liquidity risk and foreign currency risk. The policies for managing these are regularly reviewed and agreed by the board. It is and has been throughout the year under review, the Company’s policy that no trading in financial instruments shall be undertaken. Interest rate risk The Company finances its operations by cash and short term deposits. The Company’s policy on interest rate management is agreed at board level and is reviewed on an ongoing basis. Other creditors, accruals and deferred income values do not bear interest. Interest rate profile The Company had no bank borrowings at the 30 June 2014. Liquidity risk The Company seeks to manage financial risk by ensuring that sufficient liquidity is available to meet foreseeable needs and to invest cash assets safely and profitably. Fair values Fair values of financial instruments equate to the best value as disclosed in the financial information. There are no material differences between the fair value of financial instruments and the amount at which they are stated in the financial statements. 20 POST BALANCE SHEET EVENTS On 23 July 2014, the Company entered into an Equity Swap Agreement with YA Global Master SPV Ltd (“Yorkville”) under which Yorkville agreed to subscribe for 312,500,000 ordinary shares of 0.04p at a subscription price of £0.18p per share. As part of this agreement The Company paid £289,688 as a swap payment to Yorkville on 31 July 2014. In consideration for this payment the Company will receive 15 monthly payments between the date of admission to trading on AIM and 1 November 2015 the amounts of which will vary depending on the average weighted price of the ordinary shares in the preceding 10 days prior to the payment falling due. 21 RELATED PARTY TRANSACTIONS Remuneration of key management personnel The remuneration of the directors, who are the key management personnel of the Company, is set out on page 14. 35 Notes on the Financial Statements - continued 22 ULTIMATE CONTROLLING PARTY The Company does not currently have an ultimate controlling party and did not have one in this reporting year or the preceding reporting year. 36 Notice of Annual General Meeting Notice is hereby given that the annual general meeting (AGM) of Physiomics Plc (the Company) will be held on 15 December 2014 at 11.00am at the offices of Taylor Vinters LLP, Tower 42, 33rd Floor, 25 Old Broad Street, London, EC2N 1HQ for the following purposes ORDINARY BUSINESS To consider and, if thought fit, pass the following ordinary resolutions: 1. To receive and adopt the Directors’ and Auditor’s Report and the Company’s Financial Statements for the year ended 30 June 2014. 2. To re-appoint Dr Mark Chadwick as a Director of the Company. 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of the next general meeting at which annual accounts of the Company are laid and to authorise the Directors to fix their remuneration. SPECIAL BUSINESS To consider and, if thought fit, pass the resolutions set out in paragraphs 4 to 6 (inclusive): Ordinary resolution – power to allot securities 4. That the Directors be and they are generally and unconditionally authorised pursuant to section 551 of the Companies Act 2006 (the 2006 Act) to exercise all the powers of the Company to allot shares in the Company, or to grant rights to subscribe for or to convert any security into shares in the Company (relevant securities), up to an aggregate nominal amount of £225,000 provided that this authority is for a period expiring at the next annual general meeting of the Company but the Company may before such expiry make offers or agreements which would or might require relevant securities to be allotted after such expiry and the Directors may allot relevant securities in pursuance of such offer or agreement notwithstanding that the authority conferred by this resolution has expired. This authority is in substitution for all previous authorities conferred on the Directors in accordance with section 551 of the 2006 Act, but without prejudice to the allotment of any shares already made or to be made pursuant to such authorities. Special resolution – disapplication of pre-emption rights 5. That subject to the passing of resolution 4 in the Notice the Directors be given the general power to allot equity securities (as defined by section 560 of the Companies Act 2006 (the 2006 Act)) for cash pursuant to the authority conferred by resolution 4 in the Notice as if section 561(1) of the 2006 Act did not apply to any such allotment, provided that this power shall be limited to the allotment of equity securities: (a) in connection with an offer of such securities by way of rights or other pro-rata offer to holders of ordinary shares in proportion (as nearly as may be practicable) to their respective holdings of such shares, but subject to such exclusions or other arrangements as the Directors may deem necessary or expedient in relation to fractional entitlements, record dates or any legal or practical problems under the laws of any territory, or the requirements of any regulatory body or stock exchange; and (b) otherwise than pursuant to sub-paragraph (a) above up to an aggregate nominal amount of £225,000; and shall expire on the conclusion of the next annual general meeting of the Company after the passing of this resolution, save that the Company may before such expiry, make offers or agreements which would or might require equity securities to be allotted after such expiry and the Directors may allot equity securities in pursuance of any such offer or agreement notwithstanding that the power conferred by this resolution has expired. 37 Notice of Annual General Meeting - continued This resolution revokes and replaces all unexercised powers previously granted to the Directors to allot equity securities as if section 561(1) of the 2006 Act did not apply but without prejudice to any allotment of equity securities already made or agreed to be made pursuant to such authorities. Special resolution – notice period for general meetings 6. That a general meeting of the Company, other than an annual general meeting, may be called on 14 clear days’ notice provided this authority expires at the conclusion of the next annual general meeting of the Company after the date of passing of this resolution. By order of the board Elizabeth King Company Secretary 18 November 2014 NOTES 1. Pursuant to Regulation 41 of the Uncertificated Securities Regulations 2001, the Company specifies that only those members registered on the Company’s register of members at: • 6.00pm on 12 December 2014; or, • if this Meeting is adjourned, at 6.00pm on the day two business days prior to the adjourned meeting, shall be entitled to attend and vote at the Meeting. 2. If you are a member of the Company at the time set out in note 1 above, you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at the Meeting and you should have received a proxy form with this notice of meeting. You can only appoint a proxy using the procedures set out in these notes and the notes to the proxy form. 3. The return of a completed Proxy Form, other such instrument or any CREST Proxy Instruction (as described in note 11) will not prevent a shareholder attending the AGM and voting in person if he/she wishes to do so. 4. A proxy does not need to be a member of the Company but must attend the Meeting to represent you. Details of how to appoint the Chairman of the Meeting or another person as your proxy using the proxy form are set out in the notes to the proxy form. If you wish your proxy to speak on your behalf at the Meeting you will need to appoint your own choice of proxy (not the Chairman) and give your instructions directly to them. 5. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint more than one proxy to exercise rights attached to any one share. To appoint more than one proxy, please photocopy the proxy card and return all multiple proxies in one envelope. 6. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or abstain from voting) as he or she thinks fit in relation to any other matter which is put before the Meeting. 7. The notes to the proxy form explain how to direct your proxy how to vote on each resolution or withhold their vote. To appoint a proxy using the proxy form, the form must be completed, signed and sent or delivered to the Company’s Registrars, Capita Asset Services, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent, BR3 4TU and received no later than 11.00am on 12 December 2014. In the case of a member who is a company, the proxy must be executed under its common seal or signed on its behalf by an officer of the company or an attorney for the company. 38 Notice of Annual General Meeting - continued 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in respect of that share. 9. To change your proxy instructions simply submit a new proxy appointment using the methods set out above. Note that the cut-off time for receipt of proxy appointments (see below) also apply in relation to amended instructions; any amended proxy appointment received after the relevant cut-off time will be disregarded. Where you have appointed a proxy using the hard-copy proxy form and would like to change the instructions using another hard-copy proxy form, please contact the Company at its registered office. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take precedence. 10. In order to revoke a proxy instruction you will need to inform the Company’s Registrars, Capita Asset Services by sending a signed hard copy notice clearly stating your intention to revoke your proxy appointment and addressed to them at PXS, The Registry, 34 Beckenham Road, Beckenham, Kent, BR3 4TU. In the case of a member which is a company, the revocation notice must be executed under its common seal or signed on its behalf by an officer of the company or an attorney for the company. Any power of attorney or any other authority under which the revocation notice is signed (or a duly certified copy of such power or authority) must be included with the revocation notice. The revocation notice must be received by Capita Asset Services no later than 12 December 2014 at 11.00am. If you attempt to revoke your proxy appointment but the revocation is received after the time specified then, subject to the paragraph directly below, your proxy appointment will remain valid. If you have appointed a proxy and attend the Meeting in person, your proxy appointment will automatically be terminated. 11. CREST members who wish to appoint a proxy or proxies by using the CREST electronic proxy appointment service may do so for the Meeting and any adjournment of it by using the procedures described in the CREST Manual. In order for a proxy appointment made by means of CREST to be valid, the appropriate CREST message (a CREST Proxy Instruction) must be properly authenticated in accordance with Euroclear UK & Ireland Limited’s specifications and must contain the information required for such instructions, as described in the CREST Manual. The message must be transmitted so as to be received by Capita (ID RA10) not later than 48 hours before the time fixed for the AGM. For this purpose, the time of receipt will be taken to be the time (as determined by the timestamp applied to the message by the CREST Applications Host) from which Capita is able to retrieve the message by enquiry to CREST. After this time any change of instructions to proxies appointed through CREST should be communicated to the appointee through other means. Euroclear UK & Ireland Limited does not make available special procedures in CREST for any particular messages and normal system timings and limitations will apply in relation to the input of a CREST Proxy Instruction. It is the responsibility of the CREST member concerned to take such action as shall be necessary to ensure that a message is transmitted by means of the CREST system by any particular time. The Company may treat as invalid a CREST Proxy Instruction in the circumstances set out in Regulation 35(5)(a) of the Uncertificated Securities Regulations 2001. 12. In order to be valid, any form of proxy, power of attorney or other authority under which it is signed, or a notarially certified or office copy of such power or authority, must reach the Company’s Registrars, Capita Asset Services, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent, BR3 4TU not later than 48 hours before the time of the meeting. 13. A corporation which is a member can appoint one or more corporate representatives who may exercise, on its behalf, all its powers as a member provided that no more than one corporate representative exercises powers over the same share. 14. You may not use any electronic address provided either in this notice of annual general meeting, or any related documents (including the chairman’s letter and proxy form), to communicate with the Company for any purposes other than those expressly stated. 15. On 18 November 2014, the Company’s issued share capital comprised 2,031,657,920 ordinary shares of 0.04p each. Each ordinary share carries the right to vote at the AGM and, therefore, the total number of voting rights in the Company on 18 November 2014 is 2,031,657,920 ordinary shares. 16. The Directors’ letters of appointment and service contracts will be available for inspection at Tower 42, 33rd Floor, 25 Old Broad Street, London, EC2N 1HQ from 18 November 2014 until the time of the Meeting. 39 This page is intentionally blank 40 This page is intentionally blank Form of Proxy I/We (block capital) of (block capital) Being a member/members of Physiomics Plc hereby appoint the chairman of the meeting or (see note 1 and 2) in respect of Ordinary Shares (Please indicate here with an ‘X’ if this appointment is one of multiple appointments being made.) as my/our proxy to attend and on a poll to vote for me/us and on my/our behalf at the Annual General Meeting of the Company to be held on 15 December 2014 at 11.00am and at any adjournment thereof. I/we direct, by inserting a cross or other mark in the appropriate box below, how my/our votes are to be cast on each of the resolutions to be proposed at the meeting as indicated below. If no indication is given, the proxy will exercise his/ her discretion as to how he/she votes and as to whether or not he/she abstains from voting. Please complete, sign and date this form where indicated below (see notes below). ORDINARY RESOLUTIONS For Against Withheld 1. To receive and adopt the Directors' and Auditor’s report and the Company’s financial statements for the year ended 30 June 2014. 2. To re-appoint Dr Mark Chadwick as a Director. 3. To confirm the appointment of Shipleys LLP as auditors of the Company to hold office until the conclusion of the next general meeting of the Company at which annual accounts are laid and to authorise the Directors to fix their remuneration. 4. That the Directors be and they are generally and unconditionally authorised to exercise all the powers of the Company to allot relevant securities up to an aggregate nominal amount of £225,000. SPECIAL RESOLUTIONS 5. That the Directors be given the general power to allot equity securities for cash pursuant to the authority conferred by the resolution 4 as if section 561(1) of the Companies Act 2006 did not apply to any such allotment. 6. To authorise the Company to convene general meetings (other than annual general meetings) on 14 clear days’ notice. Signature(s) Date NOTES 2014 1. As a member of the Company you are entitled to appoint a proxy to exercise all or any of your rights to attend, speak and vote at a general meeting of the Company. You can only appoint a proxy using the procedures set out in these notes. 2. Appointment of a proxy does not preclude you from attending the meeting and voting in person. If you have appointed a proxy and attend the meeting in person, your proxy appointment will automatically be terminated. 3. A proxy does not need to be a member of the Company but must attend the meeting to represent you. To appoint as your proxy a person other than the Chairman of the meeting, insert their full name in the box. If you sign and return this proxy form with no name inserted in the box, the Chairman of the meeting will be deemed to be your proxy. Where you appoint as your proxy someone other than the Chairman, you are responsible for ensuring that they attend the meeting and are aware of your voting intentions. If you wish you proxy to make any comments on your behalf, you will need to appoint someone other than the Chairman and give them the relevant instructions directly. 4. You may appoint more than one proxy provided each proxy is appointed to exercise rights attached to different shares. You may not appoint more than one proxy to exercise rights attached to any one share. To appoint more than one proxy you may photocopy this form. Please indicate the proxy holder’s name and the number of shares in relation to which they are authorised to act as your proxy (which, in aggregate, should not exceed the number of shares held by you). Please also indicate if the proxy is one of multiple instructions being given. 5. To direct your proxy how to vote on the resolutions mark the appropriate box with an ‘X’. To abstain from voting on a resolution, select the relevant “Vote withheld” box. A vote withheld is not a vote in law, which means that the vote will not be counted in the calculation of votes for or against the resolution. If no voting indication is given, your proxy will vote or abstain from voting at his or her discretion. Your proxy will vote (or abstain from voting) as he or she thinks fit in relation to any other matter which is put before the meeting. 6. Any alteration to the form of proxy should be initialled. 7. All forms of proxy should be signed by the appointer or his attorney duly authorised in writing or, if the appointer is a Company, either under seal or under hand of a duly authorised officer or attorney of the Company and returned in the same envelope. 8. In the case of joint holders the signature of any one holder is sufficient. If more than one joint holder of any share is present at the meeting personally or by proxy, that one present whose name stands first on the register of members in respect of that share is alone entitled to vote in respect of that share. 9. To be valid this form of proxy and any power of attorney or other authority under which it is signed or a notarially certified copy of such power of authority must be lodged at the offices of the Company’s Registrars, Capita Asset Services, PXS, The Registry, 34 Beckenham Road, Beckenham, Kent, BR3 4TU not later than 48 hours before the time of the meeting. 10. CREST members should use the CREST electronic proxy appointment service and refer to Note 10 of the Notice of Annual General Meeting in relation to the submission of a proxy appointment via CREST. 11. If you submit more than one valid proxy appointment, the appointment received last before the latest time for the receipt of proxies will take precedence. 12. For details of how to change your proxy instructions or revoke your proxy appointment see the notes to the notice of meeting. 13. You may not use any electronic address provided in this proxy form to communicate with the Company for any purposes other than those expressly stated. 41 This page is intentionally blank 42 This page is intentionally blank 43

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