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SkinBioTherapeutics

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FY2018 Annual Report · SkinBioTherapeutics
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Annual Report and Financial Statements
For the Year Ended 30 June 2018 

SkinBioTherapeutics plc

Company Registration Number: 09632164

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SkinBioTherapeutics
15 Silk House, Park Green, Macclesfield, SK11 7QJ

 
 
 
 
 
 
 
 
 
 
 
 
 
 
Contents

Statutory and Other Information

Chairman’s Statement

Strategic and Financial Review

Directors’ Report

Corporate Governance Report

Independent Auditor’s Report to the 
Members of SkinBioTherapeutics plc

Statement of Comprehensive Income

Statement of Financial Position

Statement of Cash Flows

Statement of Changes in Equity

Notes to the Financial Statements

Notice of Annual General Meeting

Notes to the Annual General Meeting Notice

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SkinBioTherapeutics plc Annual Report & Accounts 2018  |  1

Statutory and Other Information

Directors

Secretary

Registered office

Auditor

Registrars

Nominated adviser

Broker

Bankers

Public relations

Non-Executive Chairman

Martin Hunt
Prof Catherine O’Neill Chief Executive Officer
Chief Financial Officer
Doug Quinn
Non-Executive Director
Stephen O’Hara
Non-Executive Director
Dr Cathy Prescott

Doug Quinn

15 Silk House 
Park Green 
Macclesfield 
SK11 7QJ

Jeffreys Henry LLP
Finsgate 5-7 Cranwood Street
London
EC1V 9EE

Share Registrars Limited
The Courtyard
17 West Street
Farnham
GU9 7DR

Cairn Financial Advisers LLP
Cheyne House, Crown Court
62-63 Cheapside
London
EC2V 6AX

Turner Pope Investments (TPI) Limited                        Northland Capital Partners Limited
6th Floor, Beckett House
36 Old Jewry
London
EC2R 8DD

                       40 Gracechurch Street
                       London
                       EC3V 0BT 

Barclays Bank PLC
1 Churchill Place 
London
E14 5HP

Instinctif Partners
65 Gresham Street 
London
EC2V 7NQ

2 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Chairman’s Statement

During  the  past  financial  year,  SkinBioTherapeutics’  has  focused  on  the  development  of  its  SkinBiotix®  technology  platform  and  the
preparations for the start of the cosmetic human study.

The Company has made significant progress across all aspects of these business objectives. The manufacturing process has been driven
forward, from the scale-up of the lysate material through to the development of a cosmetic formulation. Having formulated a cream and
demonstrated the extended stability of the technology, the Company has also been able to begin the first phase of its human study in
September 2018. This is an important milestone for the business and a key step towards the future commercialisation of the technology.

Costs have been managed carefully and the Company ended the year with a cash balance of £3.2m (2017: £3.9m), which is line with
management’s expectations.

Other key operational achievements which are described more fully in the CEO’s report include:

(cid:0) SkinBiotix® passed key cytotoxicity safety tests

(cid:0) replication of the lysate manufacturing process by a third party and industrial volume scale-up

(cid:0) production of a cream formulation that demonstrated the effectiveness of the SkinBiotix® technology

(cid:0) granting of patents in Australia, Russia and New Zealand

(cid:0) signing an MTA (Material Transfer Agreement) with a global consumer goods company

(cid:0) provisional ethics approval for the cosmetic human study

(cid:0) progress with the eczema and infection programmes

(cid:0) an extension to the research agreement with the University of Manchester.

Interest in the microbiome as a sector continues to grow and it is noteworthy that the cosmetic industry is transitioning to products and
applications with scientific validation. This latter development has been an important factor in the discussions the Company has had to date
with potential commercial partners. This reaffirms SkinBioTherapeutics’ strategic approach to establish itself as a ‘science-led’ skin healthcare
business.

During the current financial year, the Company expects to complete its first human study and further commercial negotiations in partnering
and licensing opportunities.

Martin Hunt
Chairman

24 October 2018

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  3

Strategic and Financial Review

Company background and strategy
SkinBioTherapeutics seeks to harness the microbiome for human health. The best understood members of the microbiome are the bacteria
that live in the gut and these have led to the rise in ingesting ‘probiotics’ to promote health. However, an increasing area of focus is the
microbiome of the skin.

SkinBioTherapeutics’ proprietary technology, SkinBiotix®, is designed to promote skin health by harnessing the beneficial properties of
probiotic bacteria and the active components derived from them. The approach taken is to use a ‘lysate’ of probiotic bacteria as a topical
agent. The use of a lysate rather than live bacteria circumvents the possible safety considerations associated with applying live bacteria to
the skin and the potential formulation difficulties of keeping bacteria alive in a cream.

The Company is developing SkinBiotix® to address a number of indications and has an ongoing research agreement with the University of
Manchester to identify and develop new and different technologies. Proof of principle studies have shown that the molecules found in the
human microbiome can be used to protect, manage and restore the skin. On the basis of this data, the Company has identified potential
applications for SkinBiotix® in the areas of cosmetics, the reduction in the incidence of eczema flares and for the prevention of infection.

Commercially, the Company intends to license its technologies to large corporates once human proof-of-principle has been established and
generate income through licence revenue. The Company is in early level discussions with a number of third parties and in April this year
signed an MTA with a global consumer goods company.

Dialogues are continuing with each of the engaged parties and a common theme from the discussions is the focus on scientific validation
which reinforces SkinBioTherapeutics’ strategy to position itself as a prominent ‘science led’ business. To this end the directors anticipate
more tangible progress on the commercial discussions on the readout of the cosmetic human study.

This route to commercialisation, in conjunction with the approach to R&D with the University of Manchester, enables the Company to operate
virtually with a small employee base and a consequently low cost of operations.

Financial review
Whilst operating expenditure has increased following the Company’s IPO in April 2017, this is in line with management forecasts and the
Company held £3.2m of cash at the year-end (2017: £3.9m).

Research and development expenditure was £416k (2017: £157k) comprising development work with the University of Manchester and the
manufacture, scale up and preparatory work for the cosmetic human study.

Ongoing operating costs were £526k (2017: £304k) covering employment, consultancy, PLC support costs and marketing. 

Overall the Company made a loss before tax of £941k (2017: £688k).

Operational review
During the year the Company achieved several important milestones with its SkinBiotix® technology – manufacture of the lysate, the passing
of key safety studies and the successful formulation of the technology into a cream.

Manufacture of the lysate had previously only been achieved on a small scale in the laboratory. However, the process of manufacture has
now been successfully replicated with a third party and subsequently scaled up by to a level appropriate for commercialisation.

In addition, the base lysate material, which to date has been manufactured and supplied in a liquid form, has now been successfully freeze
dried. The ability to freeze dry a material of this kind is an important step towards commercialisation as it enables mass production, storage
and transportation.

The technology has also passed various cytotoxicity tests and demonstrated that it is safe to use on human skin. The studies were performed
by Charles River Laboratories, a global contract research organisation (CRO). The CRO tested for adverse reactions to the use of the SkinBiotix®
technology, firstly when applied to human cells, secondly after exposure to UV and visible light and thirdly when applied to eye cells.
Successfully passing these studies was a precursor to progressing the cosmetic human study.

4 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Strategic and Financial Review (continued)

Cosmetic programme

With the scale-up and manufacture of the SkinBiotix® technology finalised, the focus with the cosmetic programme has been to establish a
formulation, containing SkinBiotix®, that can be applied to the skin and perform in the same way as the technology on its own.

Having achieved this with a cream, the formulation was then tested for its stability. Stability addresses the requirement of the technology to
be effective within the formulation over an extended period of time. This stability is specific to the formulation required for the human study
and the study duration. The Company is not intending to market the cream, rather the technology will be licensed to a third party who will
incorporate it into a product formulation with the requisite stability.

In September 2018, the Company announced it had started its human study which comprises three sub components with data readouts
occurring between November 2018 and April 2019.

Other programmes

Work in the lab this year has demonstrated that SkinBiotix® fulfils a ‘physical mode of action’ with regard to the pathogen Staphylococcus
aureus (S. aureus), i.e. it prevents the attachment of S. aureus to the skin. The skin of eczema sufferers is commonly infected with S. aureus and
there is documented evidence that this infection is the most common cause of eczema flares. On this basis, technologies that can reduce
S. aureus load on skin have the potential to reduce the incidence of flares.

The physical mode of action of SkinBiotix® allows the Company to progress the eczema programme as a medical device rather than a
pharmaceutical treatment. This regulatory pathway is potentially a faster route to market. The Company is working with its regulatory advisors
to prepare the medical device dossier for submission to the notified body. Subject to acceptance of the eczema programme following the
medical device pathway, the Company anticipates seeking approval in the second half of 2019 for the commencement of a clinical trial.

The Company considers the SkinBiotix® technology to have utility beyond general healthcare acquired infections and intends to broaden
the scope to encompass specific skin infections, for example athlete’s foot. The technology may also be effective in blocking the adhesion
of other pathogens not only to skin but also in the oral cavity or on the scalp. Hence the Company envisages a development programme to
test SkinBiotix® against a range of pathogens during the course of 2019.

Key performance indicators
The Board recognises the importance of KPIs and their appropriateness to the stage of development of the business. The Company is focused
on the development of its pre-clinical programmes all of which are cash consuming. The KPIs are therefore chosen to monitor the progress
of the individual programmes, the external market environment and the cash requirements of the Company.

Financial

The cash position of the Company is monitored on a continual basis with reference to both the ongoing operational costs of the business
and more particularly the cash requirements to support its scientific development programmes. The Company maintains a low operating
cost base such that the majority of its funding is deployed on its development programmes.

Non-financial

The Company actively monitors the progress of its development programmes. Timelines exist for each programme with key milestones
detailed and these are constantly reviewed and updated accordingly.

In addition, the Company monitors the life science market for; competitive products and technologies, licensing deals within the cosmetic
industry, scientific research related to the microbiome and regulatory and policy matters in the major markets.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  5

Principal risks and uncertainties
Ultimate responsibility for the process by which risk in the business is managed rests with the Board. The principal risks and uncertainties
facing the Company, as well as mitigating actions, are set out below. While the list is not exhaustive, it is derived from the Company’s detailed
risk register. These risks are reviewed by the Audit Committee at least biannually, which reports its findings to the Board.

The Company’s internal risk identification and management process is as follows:

(cid:0) The executive team prepares and reviews on a periodic basis, by function, the risk register for the Company. The risk register details
specific risks to the Company, the quantification of those risks in terms of probability and impact, and mitigating actions required to
manage these risks.

(cid:0) The risk register assigns responsibility for each risk and mitigation plan to one or more members of the executive team.

(cid:0) The risk register is circulated to the Board in advance of each board meeting and specific risk items may be discussed at board meetings

or otherwise as appropriate.

(cid:0) The risk register is reported to the Audit Committee at least biannually.

Stage of operations

SkinBioTherapeutics is at an early stage of development, yet to generate revenues and has a limited history to date. The ability of the business
to generate revenue depends on the successful completion of the technical and commercial development of its SkinBiotix® platform. The
business will incur losses for the foreseeable future and has not yet demonstrated an ability to complete human studies, obtain regulatory
approval or commercialise its SkinBiotix® platform successfully.

Clinical development risk

The commercialisation of the Company’s intellectual property and the potential applications of its technology platform requires pre-clinical
development, formulation, process development and human consumer/clinical studies that exemplify platform claims. There is a risk that
the business’s SkinBiotix® platform does not perform as expected and it fails to perform in the applications identified by the Company.

Furthermore, clinical development and human studies can result in unexpected costs. Agreeing study designs, study endpoints and study
recruitment timelines without unforeseen delays with regulatory agencies is key. Regulatory body guidelines leading to market authorisation
may be subject to alteration and are divergent in different jurisdictions.

Product development timelines

The Company has identified a number of applications for its SkinBiotix® technology platform. Development programme delays, inconclusive
results, identification of safety issues, manufacture and formulation failures or regulatory challenges may require additional follow-up studies
that are not currently envisaged with a consequential impact on development timelines and cash resources.

Dependence of key personnel

The Company’s operates with a small team and success is highly dependent on the expertise and experience of its board, management and
employees. Retention and incentivisation of these individuals is critical to the Company.

Formulation

Whilst the Company has developed a formulation appropriate for the cosmetic human study further work is required to ensure the formulation
remains effective for an extended period. There are risks associated with the means and timeline in establishing the long-term stability of
the formulation. In addition, the Company will need to develop formulations appropriate for its other indications. It may require a number
of iterations before suitable formulations are able to be produced.

Human studies

SkinBioTherapeutics has invested effort and resources in its SkinBiotix® technology platform and the potential applications of the technology.
Success in human studies in part hinges on this continuing development activity. It is however possible that the results of these studies may
not be predictive of those obtained in more advanced, later-stage, expensive, time consuming and difficult to design human studies.

6 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Strategic and Financial Review (continued)

Intellectual property and proprietary technology

SkinBioTherapeutics is focused on maintaining and expanding its intellectual property portfolio. The portfolio includes patent applications,
trademarks and know-how.

Success of the Company will depend in part on its ability to obtain and maintain effective patent rights. These rights need to be sufficiently
broad to protect SkinBioTherapeutics’ technology in its chosen markets. The application process is expensive and time-consuming and
SkinBioTherapeutics may not be able to file all its patent applications in all jurisdictions.

Some of the Company’s patent applications remain pending and have not been given notice of allowance. National patent offices may raise
objections in relation to the on-going patent applications. These may result in revised applications or prevent patent applications from being
granted.

Competitive risk

The directors believe the skin microbiome to be an innovative area of development and scientific focus. As such this area is subject to
significant and rapid technological and consumer change. It is an area of interest to academic institutions, government agencies and private
and public companies. Competition from existing companies and new entrants is beginning to emerge and maintaining an IP and technology
advantage over the competition will require a sustained development focus.

The need for safe and supportive skin health and well-being products is acknowledged by consumers and healthcare providers around the
globe. Large multinationals have divisions dedicated to the sector and many have established brands or approved products on the market.
These brand owners have greater financial and human resources which can be deployed to build and maintain a brand position. Many also
have dedicated R&D units and could therefore choose to develop technologies that compete with the Company’s SkinBiotix® technology
platform.

Regulatory environment

The Company operates in a regulated environment that varies dependent upon the jurisdiction. These regulations are subject to change at
short notice and differ according to any proposed product claims, intended use or marketing route. While the Company will take every effort
to ensure that it and its partners comply with all applicable regulations, there can be no guarantee of this. Failure to comply with applicable
regulations could result in the Company being unable to successfully commercialise its technology or any products that incorporates it
and/or result in legal action being taken against the Company which could have a material adverse effect.

Brexit

It is unclear how Brexit will impact the regulatory environment with the relocation of the European Medicines Agency (EMA) and whether
the Company will require separate approvals for future trade in Europe. The Company may incur delays and additional costs depending on
the outcome of the Brexit negotiations and the transition of regulatory approvals.

Outlook
Having established manufacturing scale-up and formulated an effective cream, the human study initiated in September defined an important
phase for the Company. A positive readout from the study will be an important validation of the SkinBiotix® technology and a basis to further
progress the various commercial discussions that are in hand.

Reaffirming and progressing the eczema programme as a medical device following the preliminary regulatory assessment will also be a
significant workstream in 2019 together with establishing programmes to address other skin infections and assess the impact of SkinBiotix®
on other pathogens.

Good progress has been made this year across the business and the Board and management team are optimistic for the outlook in 2019.

Prof Catherine O’Neill 
CEO

24 October 2018

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  7

Directors’ Report

The directors present their report and the audited financial statements of the Company for the year ended 30 June 2018.

Principal activity
The principal activity of the Company is that of research and development into the effects of lysates derived from the human microbiome
on skin.

Directors
The directors who served the Company during the year and to the date of these financial statements were:

Prof Catherine O’Neill
Doug Quinn
Martin Hunt
Dr Cathy Prescott
Stephen O’Hara

Chief Executive Officer
Chief Financial Officer
Non-Executive Chairman
Non-Executive Director
Non-Executive Director

The directors of the Company held the following beneficial interests in the share and share options of SkinBioTherapeutics plc at the date of
this report:

Prof Catherine O’Neill

Martin Hunt*

Doug Quinn

Issued share capital

Ordinary shares
of £0.01 each

Percentage 
held

5,256,989

466,667

444,444

4.4%

0.4%

0.4%

Share options
Ordinary              Options 
shares of             exercise
£0.01 each                    price

3,892,082                   £0.09

3,892,082                   £0.09

2,594,721                   £0.09

* Martin Hunt’s shareholding is held through Invictus Management Limited, a company controlled by Mr Hunt. Of the 466,667 shares held by Invictus Management Limited 11,112

are held in trust for Louise Hunt and 11,111 are held in trust for Oliver Hunt.

Substantial shareholdings
As at 19 October 2018, the following interests in 3% or more of the issued share capital appear in the register:

OptiBiotix Health Plc

Seneca Partners Limited

University of Manchester

Prof Catherine O’Neill

Prof Andrew McBain

                                                              Percentage of 
                                                  issued share capital
                 41.9%

                 14.6%

                    6.7%

                    4.4%

                    3.5%

Directors remuneration
The directors received the following remuneration during the year:

Executive                                                                                  Salaries
Prof Catherine O’Neill                                                           £39,929

         Share based                      Pension                             Total 
Fees               payments          contributions           remuneration
–                   £24,620                           £214                       £64,763

Doug Quinn                                                                           £12,260

£56,303                   £16,414                              £45                       £85,022

Non-executive
Martin Hunt                                                                              £6,015

£24,068                   £24,620                                  –                       £54,703

Dr Cathy Prescott                                                                     £4,016

£16,067                               –                                  –                       £20,083

Stephen O’Hara                                                                        £4,017

£16,067                               –                                  –                       £20,084

                                                                                                £66,237

£112,505                     £65,654                               £259                      £244,655

                                                                                                                      
8 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Directors’ Report (continued)

Financial instruments

The Company’s exposure to financial risk is set out in note 2m) of the financial statements.

Research and development
The Strategic and Financial Review on pages 3-6 gives information of the Company’s research and development activities.

Events after the reporting date
Refer to note 18 to the financial statements for further details.

Going concern
The financial statements have been prepared on the assumption that the Company is a going concern. When assessing the foreseeable
future, the directors have considered the budget for the next 12 months from the date of this report and the cash at bank available as at the
date of approval of this report and are satisfied that the Company should be able to meet its financial obligations.

After making enquiries, the directors have a reasonable expectation that the group has adequate resources to continue in operational
existence for the foreseeable future. Accordingly, they continue to adopt the going concern basis in preparing the annual report and financial
statements.

Statement of directors’ responsibilities
The directors are responsible for preparing the Strategic Report and Directors’ Report and the financial statements in accordance with
applicable law and regulations.

Company law requires the directors to prepare financial statements for each financial year. Under that law the directors have elected to
prepare the financial statements in accordance with International Financial Reporting Standards (IFRSs) as adopted by the European Union.
Under company law the directors must not approve the financial statements unless they are satisfied that they give a true and fair view of
the state of affairs and profit or loss of the Company for that period. In preparing these financial statements, the directors are required to:

(cid:0) select suitable accounting policies and then apply them consistently

(cid:0) make judgements and accounting estimates that are reasonable and prudent

(cid:0) state whether applicable IFRSs have been followed subject to any material departures disclosed and explained in the financial statements

(cid:0) prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Company will continue in

business.

The directors are responsible for keeping adequate accounting records that are sufficient to show and explain the Company’s transactions
and disclose with reasonable accuracy at any time the financial position of the Company and enable them to ensure that the financial
statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Company and hence for taking
reasonable steps for the prevention and detection of fraud and other irregularities. The directors confirm that:(cid:0)

(cid:0) so far as each director is aware, there is no relevant audit information of which the Company’s auditor is unaware

(cid:0) the directors have taken all the steps that they ought to have taken as directors in order to make themselves aware of any relevant audit

information and to establish that the Company’s auditor is aware of that information.

The directors are responsible for the maintenance and integrity of the corporate and financial information included on the Company’s
website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation
in other jurisdictions.

Auditors
Jeffrey’s Henry LLP will be proposed for re-appointment as auditors at the forthcoming Annual General Meeting. 

This report was approved by the Board of Directors on 24 October 2018 and signed on its behalf by: (cid:0)

Prof Catherine O’Neill

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  9

Corporate Governance Report 

As Chairman of SkinBioTherapeutics I have overall responsibility for corporate governance and in promoting high standards throughout the
Company. As well as leading and chairing the Board my responsibilities are to ensure:

(cid:0) committees are properly structured and operate with appropriate terms of reference

(cid:0) the performance of individual directors, the Board and its committees are reviewed on a regular basis

(cid:0) the Company has a coherent strategy and sets objectives against this

(cid:0) there is effective communication between the Company and its shareholders.

All the directors of SkinBioTherapeutics believe strongly in the importance of good corporate governance for the creation of shareholder
value over the medium to long-term and to engender trust and support amongst the Company’s wider stakeholders.

In March 2018, changes to the AIM rules required the formal adoption by all AIM companies of a recognised corporate governance code by
28 September 2018. On its admission to AIM in April 2017 the directors undertook to take account of the requirements of the QCA guidelines
to the extent they consider it appropriate having regard to the Company’s size, board structure, stage of development and resources.

In light of the new requirements under AIM rule 26, the Board have decided to formally adopt and adhere to the QCA code (revised in April
2018).

The QCA code is constructed around ten broad principles and a set of disclosures. The QCA has stated what it considers to be appropriate
arrangements for growing companies and asks companies to provide an explanation about how they are meeting the principles through
the prescribed disclosures. The directors have considered how they apply each principle to the extent the Board judges these to be
appropriate in the circumstances and below we provide an explanation of the approach taken in relation to each. The Board considers that
it does not depart from any of the principles of the QCA code. There were no key governance related matters that occurred during the year.

Martin Hunt, Chairman.

Principle
Establish  a  strategy  and  business  model  which
promotes long-term value for shareholders

Application
SkinBioTherapeutics seeks to harness the microbiome for human health and
has a particular focus on skin. The Company’s proprietary technology is targeted
at a number of health indications and the Company is initially focused on a
cosmetic  application  as  a  route  to  initial  value  creation.  The  Company’s
programme  of  research  and  development  is  intended  to  build  long-term
shareholder  value  through  a  reliance  on  proven,  rigorous  science  and  the
Company utilises its public listing as a means to source capital to support its
R&D programme.

The  Company  has  an  ongoing  research  agreement  with  the  University  of
Manchester to identify and develop technologies. In doing so the Company
intends to avoid a reliance on a single technology and ensure that it has an
ongoing pipeline of technologies, all related to the human microbiome, at
different stages of development. The Company will seek to license technologies
to large corporates once human proof of principle has been established and
intends to generate licence revenue through this route. It operates as a virtual
organisation  with  a  small  but  experienced  management  team  and  a  low
operating cost base.

     
10 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Corporate Governance Report (continued)

Principle
Seek to understand and meet shareholder needs and
expectations

Application
The Board is committed to communicating openly with shareholders to ensure
that  its  strategy  and  performance  are  clearly  understood.  Between  the
Chairman  and  the  executive  directors  an  open  and  regular  dialogue  is
maintained with the Company’s major shareholders which comprise;

Shareholder                                                                     Holding (19 October 2018)

OptiBiotix Health Plc                                                                                      41.9%

Seneca Partners Limited                                                                                14.6%

University of Manchester                                                                                 6.7%

Prof Cath O’Neill                                                                                                4.4%

Prof Andrew McBain                                                                                         3.5%

Both  the  University  of  Manchester  and  Andrew  McBain  sold  shares  in  the
Company in the period June 2018 – August 2018. The sales of these shares were
actioned in conjunction with the Company’s brokers to maintain an orderly
market.

The 

Company 

participate. 

also  maintains

More generally the Board communicates with shareholders through the Annual
Report and the Interim Statement, trading and other announcement made on
RNS and at the Annual General Meeting where the Board encourages investors
a  website,
to 
www.skinbiotherapeutics.com, which contains information on the Company’s
business  and corporate  information.  Following  the  announcement  of  the
Company’s  half  year  and  full  year  results  the  Chief  Executive  &  CFO,  make
presentations  to  institutional  shareholders,  private  client  brokers  and
investment  analysts.  Existing  and  prospective  shareholders  are  able  to
separately contact the Chairman and Chief Executive via email as detailed on
the  Company’s  website.  Periodic  meetings  are  held  with  existing  and
prospective institutional and other investors and the Company presents at
private investment events during the course of the year. The Company’s brokers
also produce periodic research notes on the Company.

Take  into  account  wider  stakeholder  and  social
responsibilities and their implications for long-term
success

As a small company engaged in the early stages of technology development
the Company has a limited but important number of stakeholders. Robust
science  is  at  the  core  of  the  Company’s  strategy  and  the  Company  has  a
number of key stakeholders, including its employees, involved in the different
stages  from  research,  through  manufacture,  formulation  and  testing.  The
Company assesses each of the companies it works with to ensure the requisite
standards and values are in place. Ultimately the Company’s technology will be
used by consumers and ensuring the appropriate development, manufacture
and marketing of products will be key to the long-term success of the Company.
Throughout the various stages from initial technology identification to eventual
product sales the Company is engaged in a continual process of feedback and
improvement  with  its  stakeholders,  including  eventual  end  users.  The
Company’s  strategy  is  not  to  market  its  own  products  and  therefore  the
eventual  licencees  will  be  important  stakeholders  in  the  interface  with
consumers and the longer-term success of the Company.

     
     
Principle
Embed effective risk management, considering both
opportunities 
the
organisation

throughout 

threats, 

and 

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  11

Application
Ultimate responsibility for the process by which risk in the business is managed
rests  with  the  Board.  The  Company’s  internal  risk  identification  and
management process is as follows:

(cid:0) The executive team  prepares  and  reviews  on  a  periodic  basis  the  risk
register  for  the  Company.  The  risk  register  details  specific  risks  to  the
Company,  the  quantification  of  those  risks  in  terms  of  probability  and
impact, mitigating actions required to manage these risks and the control
mechanisms that are in place to monitor the risks.

(cid:0) The risk register assigns responsibility for each risk and the mitigation plan

to one or more members of the executive team.

(cid:0) The risk register is circulated to the Board in advance of each board meeting
and specific risk items may be discussed at board meetings or otherwise as
appropriate.

(cid:0) The risk register is reported to the Audit Committee at least biannually.

Maintain the Board as a well-functioning, balanced
team led by the chair

The Board’s primary role is to enhance shareholders’ long-term interests by:

(cid:0) determining the Company’s overall strategy and direction

(cid:0) establishing  and  maintaining  controls,  audit  processes  and  risk
management policies to ensure they counter identified risks and that the
Company operates efficiently

(cid:0) ensuring effective corporate governance

(cid:0) approving budgets and reviewing performance relative to those budgets

(cid:0) approving financial statements

(cid:0) approving material agreements and non-recurring projects, and

(cid:0) approving senior and board appointments.

Martin  Hunt  and  Dr  Cathy  Prescott,  both  non-executive  directors,  are
considered to be independent of the management and are free to exercise
independence of judgement. Stephen O’Hara, by virtue of his position as Chief
Executive of OptiBiotix Health Plc, the Company’s largest shareholder is not
considered to be independent.

The  non-executive  directors  are  required  to  commit  sufficient  time  as  is
necessary, approximately two days per month, to fulfil their obligations. Routine
commitments include preparation for and attendance at board and committee
meetings. In addition, the non-executive directors engage in ad-hoc dialogues
with members or the executive team, shareholders and other stakeholders as
required.

All directors are subject to reappointment by shareholders at the first Annual
General Meeting following their appointment and thereafter by rotation.

The table on page 17 details the attendance record of each director at board
and committee meetings during the course of the year.

     
     
12 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Corporate Governance Report (continued)

Principle
Ensure  that  between  them  the  directors  have  the
necessary  up-to-date  experience, 
skills  and
capabilities

Application
As  at  30  June  2018  the Board  comprised  an  independent  non-executive
chairman, two executive directors and two non-executive directors – one of
which is independent. Two directors are female and three are male.

Martin Hunt, Independent Non-Executive Chairman

Appointed as a director & Chairman in October 2016; Chair of the Remuneration
Committee and member of the audit and insider committees.

Martin has had a long executive career in the medtech and life science sectors
including  sales  and  general  management  roles  with  large  corporations  in
Europe and the US. He was previously CEO of biomaterials company Tissue
Science Laboratories plc taking it from start-up through an AIM listing and
eventual sale to Covidien. More recently he has held a number of non-executive
roles with both private and public companies. Martin is well versed in the early
and growth stages of companies in the life science sector as well as bringing
experience of corporate governance and shareholder communications.

Martin is the Programme Director of the NIHR translational funding programme
Invention for Innovation (i4i) and a member of the NIHR Strategy Board. Martin
is currently Non-Executive Chairman of Videregen Limited and a non-executive
director of Biotec Pharmacon and MDY Healthcare Limited.

Time commitment of at least two days per month.

Professor Cath O’Neill, CEO

Appointed as a director in March 2016 and CEO in March 2017.

Cath is an accomplished scientist and Professor of Translational Dermatology at
the School of Biological Services, University of Manchester. Cath has previously
founded a specialist dermatology university spinout and as a subject matter
expert has advised a number of global corporations. Cath is experienced in taking
technology from the bench and through the stages to manufacture a product. 

Through her interactions with global companies Cath is familiar with both the
scientific and commercial demands to take a technology to market.

Cath’s  services  are  provided  under  a  secondment  agreement  with  the
University of Manchester whereby she spends 75% of her time fulfilling the
duties of the Company.

Doug Quinn, CFO

Appointed as director and CFO in December 2016 and Company Secretary in
January 2017; Member of the audit and insider committees.

Doug has been involved in early stage companies through a combination of
investor, executive and non-executive director and CFO roles for over 18 years.
He  was  CFO  of  Arthro  Kinetics  Limited,  an  early  stage  tissue  engineering
company and part of the team that floated the Company on AIM in 2006. A
chartered management accountant, with a number of years of experience in
the life science sector, he brings financial expertise gained through executive
roles and corporate finance transactions.

Time commitment of between 2-3 days per week.

Doug is a director and part-time CFO with the life science company Videregen
Limited.

     
SkinBioTherapeutics plc Annual Report & Accounts 2018  |  13

Principle

Application

Stephen O’Hara, Non-Executive Director

Appointed  as  a  director  in  March  2015;  Member  of  the  Remuneration
Committee.

Stephen is CEO of OptiBiotix Health Plc, an AIM listed company he founded in
2012 to exploit the opportunities emerging in the field of the microbiome. He
has  spent  over  30  years  working  in  microbiology  and  healthcare  and  has
managed the growth of OptiBiotix from a start-up to an AIM listed company with
a market capitalisation of £80m. Stephen brings sector and technology expertise
as well as considerable experience as CEO of a public company encompassing
corporate governance, fundraising and shareholder management.

Time commitment of two days per month.

Dr Catherine Prescott, Independent Non-Executive Director 

Appointed as a director in March 2017; Chair of the Audit Committee.

Cathy has over two decades of experience in research and management in the
biotech, pharmaceutical and venture capital sectors. Cathy is a visiting professor
at Kings College London, teaching on the MSc programme ‘Cellular Therapies
from bench to market’. Cathy brings a broad range of scientific and strategic
sector expertise and experience.

She is non-executive director of Videregen Limited and the International Medical
Education Trust. Time commitment of two days per month.

The Board has not, at this stage in its development, established a nominations
committee. The Board as a whole continues to review its structure in order to
provide what it considers to be an appropriate balance of executive and non-
executive experience and skills. The Board believes that its blend of relevant
experience, skills, personal qualities and capabilities is sufficient to enable it to
successfully execute its strategy. The Board is additionally cognisant that as the
Company seeks to commercialise its technology, this may require additions to
the executive team and wider Board.

Directors attend seminars and other trade events to ensure that their knowledge
remains current.

On the formation of the Board the directors considered the composition of the
Audit Committee. Doug Quinn is an executive director and CFO but a member
of the Committee due to his experience in this area. Both independent directors
have direct access to the auditors with the exclusion of Doug and vice versa and
he is excused from any discussions where there is a potential conflict of interest.
In September 2017 the Audit Committee met with the Company’s accountants,
Jeffrey’s Henry, for a briefing session on the role and contribution of the Audit
Committee. The Company Secretary also prepared a briefing note on the role
and responsibilities of the Audit Committee which was reviewed and discussed.

From time to time the Board may require third party advice on various matters
pertaining to its business, for example in relation to the competitive landscape.
Appropriate relationships to source such advice have been established.

     
14 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Corporate Governance Report (continued)

Principle
Evaluate  board  performance  based  on  clear  and
relevant objectives, seeking continuous improvement

Promote a corporate culture that is based on ethical
values and behaviours

Application
The current Board was established as part of the Company’s preparation for
admission  to  AIM  in  April  2017,  bringing  together  the  requisite  skills  and
experience  to  target  the  Company’s  objectives,  with  a  focus  on  the  initial
growth  stage.  Whilst  Board  effectiveness  has  been  subject  to  informal
discussions  amongst  the directors  the  Board  has  yet  to  formally  review  its
performance but will do so through the course of the current financial year.
This  will  be  an  internal  review  managed  by  the  Chairman.  The  review  is
expected to be repeated on an annual basis.

It  is  anticipated  that  the  process  will  involve  each  director  completing  a
questionnaire as to the effectiveness of the Board and a self-assessment of their
own contributions. These will be returned to the Chairman and will form the
basis of individual discussions with each of the directors and a subsequent
discussion with the Board as a whole.

The Board’s approach to succession planning is based upon identifying the
medium to long term objectives of the Company and matching these against
the  competence  of  directors  and  senior  managers.  The  Board  will  seek  to
identify potential gaps and recruit to fill these allowing a sufficient lead time.

The Board believes that the promotion of a corporate culture based on sound
ethical values and behaviours is essential to maximise shareholder value. The
Board considers this particularly relevant to the Company in light of the partners
with which it works, for example the University of Manchester, and recognising
the intended end use of its technology in products to be marketed to and
purchased by consumers. The Company operates virtually and aside from its
board has only one full-time employee. The executive team engenders open
and  positive  interactions  with  a  key  focus  on;  scientific  rigour,  innovation,
creative solutions and collective responsibility. As the Company expands its
human capability it will look to formalise its culture through an agreed set of
values and standards.

The Company’s policies set out its zero-tolerance approach towards any form
of modern slavery, discrimination or unethical behaviour relating to bribery,
corruption or business conduct.

Maintain governance structures and processes that
are fit for purpose and support good decision-making
by the Board

Alongside  setting  the  vision  and  strategy  for  the  Company  the  Board  is
responsible to ensure that the business is managed for the long-term benefit
of all shareholders whilst having regard for internal and external stakeholders,
including employees, customers and suppliers.

The Board defines a series of matters reserved for its decision and has approved
terms of reference for its audit, remuneration and insiders committees to which
certain responsibilities are delegated. The chair of each committee reports to
the Board on the activities of that committee.

     
     
     
SkinBioTherapeutics plc Annual Report & Accounts 2018  |  15

Principle

Application
The Audit Committee is responsible for:

(cid:0) reviewing  the  annual  financial  statements  and  interim  reports  prior  to

approval

(cid:0) reviewing and considering reports on internal financial controls, including

reports from the auditors

(cid:0) considering the appointment of and reviewing the relationship with the
auditors,  including  reviewing  and  monitoring  of  independence  and
objectivity

(cid:0) reviewing the consistency of accounting policies

(cid:0) considering any proposed related party transaction.

The Audit Committee can call for information from the executive team and
consults with the external auditors directly when appropriate or when they are
required to do so.

The Remuneration Committee reviews and determines on behalf of the Board
the pay, benefits and other terms of service of the executive directors of the
Company. 
the  creation  and
implementation of all employee share plans.

the  committee  oversees 

In  addition, 

The Insider Committee is responsible for:

(cid:0) monitoring and ensuring compliance with the Company’s MAR dealing

policy

(cid:0) reviewing the classification of employees, directors and key consultants as

regards clearance requirements

(cid:0) reviewing  and  approving  or  rejecting  as  appropriate  all  requests  for

dealings in shares in the Company.

Matters reserved for the Board are:

(cid:0) determining the Company’s overall strategy and direction

(cid:0) establishing  and  maintaining  controls,  audit  processes  and  risk
management policies to ensure they counter identified risks and that the
Company operates efficiently

(cid:0) ensuring effective corporate governance

(cid:0) approving budgets and reviewing performance relative to those budgets

(cid:0) approving financial statements

(cid:0) approving material agreements and non-recurring projects, and

(cid:0) approving senior and Board appointments.

The  Chairman  has  overall  responsibility  for  corporate  governance  and  in
promoting high standards throughout the Company. As well as leading and
chairing the Board, the Chairman’s responsibilities are to ensure:

(cid:0) committees are properly structured and operate with appropriate terms of

reference

(cid:0) the performance of individual directors, the Board and its committees are

reviewed on a regular basis 

     
16 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Corporate Governance Report (continued)

Principle

Communicate how the Company is governed and is
performing  by  maintaining  a  dialogue  with
shareholders and other relevant stakeholders

Application
(cid:0) the Company has a coherent strategy and sets objectives against this

(cid:0) there  is  effective  communication  between  the  Company  and  its

shareholders.

The CEO provides coherent leadership and management of the Company, leads
the development of objectives, strategies and performance standards as agreed
by the Board, ensures that the assets of the Company are maintained and
safeguarded, leads on investor relations activities to ensure communications
and the Company’s standing with shareholders and financial institutions is
maintained.

The non-executive directors contribute independent thinking and judgement
through the application of their external experience and knowledge, scrutinise
the  performance  of  management,  provide  constructive  challenge  to  the
executive  directors  and  ensure  that  the  Company  is  operating  within  the
governance and risk framework approved by the Board.

The  Company  Secretary  is  responsible  for  providing  clear  and  timely
information flow to the Board and its committees and supports the Board on
matters of corporate governance and risk. This role is currently filled by the
Company’s CFO. The Board acknowledges the QCA guidelines on this matter
and consider the joint roles appropriate for the Company’s size. The Company
Secretary  has  direct  access  to  the  Chairman  on  matters  of  corporate
governance.

In addition to the investor relations activities described above the following
committee reports are provided;

The Audit Committee, which comprises Dr Cathy Prescott (Chair), Martin Hunt
and Doug Quinn, met twice during the course of the year. The Committee met
with  the  external  auditors  prior  to  the  approval  of  the  annual  accounts.
Consideration was given to the auditors’ pre and post audit reports and these
provided opportunities to review the accounting policies, internal controls and
the financial information contained within both the annual and interim reports.
The  Committee  engaged  the  external  auditors  for  a  review  of  the  interim
statement prior to its release.

The Remuneration Committee is comprised of Martin Hunt (Chair) and Stephen
O’Hara and met once during the course of the year.

Remuneration packages for the executive directors comprise a basic salary and
performance  related  bonus.  There  is  a  compulsory  government  pension
contribution  scheme  in  place  for  all  directors  and  employees.  In  addition,
executive directors and senior employees participate in a share option long
term incentive plan.

     
     
Principle

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  17

Application
The  structure  of  the  remuneration  packages  was  established  ahead  of  the
Company’s IPO in April 2017 and agreed as remaining appropriate. In setting
remuneration,  the  committee  took  into  consideration  the  compensation
packages of comparable AIM listed companies. No new share option awards
were made. The committee extended the vesting period of options granted to
a consultant to the Company in April 2017.

The Insiders Committee, comprised of Doug Quinn (Chair) and Martin Hunt,
met three times during the course of the year to review the Company’s insider
lists and review and approve requests for dealing in shares in the Company.

For information regarding the voting of shareholders at general meetings of
the Company please see the Shareholder Information section of the website.

Director meeting attendance
                                                      PLC board meetings                                                                      Committee meetings
                                                                                                                              Audit                                    Remuneration                                Insider
                                                 Eligible to        Attended      Eligible to        Attended      Eligible to        Attended      Eligible to        Attended
Director                                       attend                                           attend                                           attend                                          attend                               

Martin Hunt                                          9                        9                        2                         2                        1                        1                        3                         3

Stephen O’Hara                                    9                        8                        –                         –                        1                        1                        –                         –

Prof Catherine O’Neill                         9                        9                        –                         –                        –                        –                        –                         –

Dr Cathy Prescott                                 9                        9                        2                         2                        –                        –                        –                         –

Doug Quinn                                          9                        9                        2                         2                        –                        –                        3                         3

     
18 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Independent Auditors’ Report To The Members of
SkinBioTherapeutics plc 

Opinion
We have audited the financial statements of SkinBioTherapeutics Plc for the year ended 30 June 2018 which comprise the statement of
comprehensive income, the statement of financial position, the statement of cash flows, the statement of changes in equity and notes to
the financial statements, including a summary of significant accounting policies.

The financial reporting framework that has been applied in the preparation of the financial statements is applicable law and International
Financial Reporting Standards (IFRSs) as adopted by the European Union.

In our opinion:

(cid:0) the financial statements give a true and fair view of the state of the Company’s affairs as at 30 June 2018 and of the Company’s loss for

the year then ended;

(cid:0) the financial statements have been properly prepared in accordance with IFRSs as adopted by the European Union;

(cid:0) the financial statements have been prepared in accordance with the requirements of the Companies Act 2006.

Basis for opinion
We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under
those standards are further described in the Auditor’s responsibilities for the audit of the financial statements section of our report. We are
independent of the Company in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK,
including the FRC’s Ethical Standard as applied to SME listed entities, and we have fulfilled our other ethical responsibilities in accordance with
these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern
We have nothing to report in respect of the following matters in relation to which the ISAs (UK) require us to report to you where:

(cid:0) the Directors’ use of the going concern basis of accounting in the preparation of the financial statements is not appropriate; or

(cid:0) the Directors have not disclosed in the financial statements any identified material uncertainties that may cast significant doubt about
the Company’s ability to continue to adopt the going concern basis of accounting for a period of at least twelve months from the date
when the financial statements are authorised for issue.

Key audit matters
Key audit matters are those matters that, in our professional judgment, were of most significance in our audit of the financial statements of
the current period and include the most significant assessed risks of material misstatement (whether or not due to fraud) we identified,
including those which had the greatest effect on: the overall audit strategy, the allocation of resources in the audit; and directing the efforts
of the engagement team. These matters were addressed in the context of our audit of the financial statements as a whole, and in forming
our opinion thereon, and we do not provide a separate opinion on these matters. This is not a complete list of all risks identified by our audit.

Key audit matter
Intangible assets

The Company had IP amounting to £215,412 at 01 July 2017. During
the year the Company capitalised a further £72,260 (2017: £79,198)
relating to intellectual property.

These capitalised costs are not yet being amortised as the product is
in the development stage.

The Directors have assessed whether the costs meet the criteria for
capitalisation and whether there are any indicators of impairment.

We focused on whether the costs capitalised met the criteria for
capitalisation.

How our audit addressed the key audit matter
We considered whether the nature of the costs met the criteria for
the costs to be capitalised.

We vouched a sample of the costs capitalised to invoices to confirm
that they relate to intellectual property.

We considered whether the Directors’ policy for the treatment of
such costs was reasonable and assessed whether the costs included
in the reconciliation were in line with the Directors’ policy.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  19

Our application of materiality
The scope of our audit was influenced by our application of materiality. We set certain quantitative thresholds for materiality. These, together
with qualitative considerations, helped us to determine the scope of our audit and the nature, timing and extent of our audit procedures on
the individual financial statement line items and disclosures and in evaluating the effect of misstatements, both individually and in aggregate
on the financial statements as a whole.

Based on our professional judgment, we determined materiality for the financial statements as a whole as follows:

Overall materiality

How we determined it

Rationale for benchmark applied

Financial statements
£70,000 (30 June 2017: £59,000).

Based on an average of 10% of loss before tax and 1.5% of gross assets.

We believe that loss before tax is the primary measure used by the
shareholders in assessing the performance of the Company, whilst
gross assets values are a representation of the size of the Company.
Both are generally accepted auditing benchmarks. 

We agreed with the Audit Committee that we would report to them misstatements identified during our audit above £3,500 (30 June 2017:
£2,950) as well as misstatements below those amounts that, in our view, warranted reporting for qualitative reasons.

An overview of the scope of our audit
As part of designing our audit, we determined materiality and assessed the risks of material misstatement in the financial statements. In
particular, we looked at where the Directors made subjective judgments, for example in respect of significant accounting estimates that
involved making assumptions and considering future events that are inherently uncertain. As in all of our audits we also addressed the risk
of management override of internal controls, including evaluating whether there was evidence of bias by the Directors that represented a
risk of material misstatement due to fraud.

How we tailored the audit scope

We tailored the scope of our audit to ensure that we performed enough work to be able to give an opinion on the financial statements as a
whole, taking into account the accounting processes and controls, and the industry in which they operate.

Other information
The Directors are responsible for the other information. The other information comprises the information included in the annual report, other
than the financial statements and our auditor’s report thereon. Our opinion on the financial statements does not cover the other information
and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether
the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears
to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine
whether there is a material misstatement in the financial statements or a material misstatement of the other information. If, based on the
work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.
We have nothing to report in this regard.

Opinions on other matters prescribed by the Companies Act 2006
In our opinion, based on the work undertaken in the course of the audit:

(cid:0) the information given in the strategic report and the Directors’ report for the financial year for which the financial statements are prepared

is consistent with the financial statements; and

(cid:0) the strategic report and the Directors’ report have been prepared in accordance with applicable legal requirements.

20 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Independent Auditors’ Report To The Members of
SkinBioTherapeutics plc (continued) 

Matters on which we are required to report by exception
In the light of the knowledge and understanding of the Company and its environment obtained in the course of the audit, we have not
identified material misstatements in the Directors’ report.

We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in
our opinion:

(cid:0) adequate accounting records have not been kept by the Company; or

(cid:0) the financial statements are not in agreement with the accounting records and returns; or

(cid:0) certain disclosures of Directors’ remuneration specified by law are not made; or

(cid:0) we have not received all the information and explanations we require for our audit.

Responsibilities of Directors
As explained more fully in the Directors’ responsibilities statement set out on page 8, the Directors are responsible for the preparation of the
financial statements and for being satisfied that they give a true and fair view, and for such internal control as the Directors determine is
necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the Directors are responsible for assessing the Company’s ability to continue as a going concern,
disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the Directors either intend
to liquidate the Company or to cease operations, or have no realistic alternative but to do so.

Auditor’s responsibilities for the audit of the financial statements
Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement,
whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance,
but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists.
Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected
to influence the economic decisions of users taken on the basis of these financial statements.

A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Council’s website at
www.frc.org.uk/auditorsresponsibilities. 

This description forms part of our auditor’s report.

Use of this report
This report is made solely to the Company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our
audit work has been undertaken so that we might state to the Company’s members those matters we are required to state to them in an
auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other
than the Company and the Company’s members as a body, for our audit work, for this report, or for the opinions we have formed.

Sanjay Parmar 

(Senior Statutory Auditor)

For and on behalf of
Jeffreys Henry LLP, Statutory Auditor
Finsgate
5-7 Cranwood Street
London
EC1V 9EE

24 October 2018

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  21

Statement of Comprehensive Income 

For the Year Ended 30 June 2018

Continuing operations
Research and development
Initial public offering costs
Operating expenses

Loss from operations
Finance costs

Loss before taxation
Taxation

Loss for the year
Other comprehensive income

Total comprehensive loss for the year

Basic and diluted loss per share (pence)

The notes on pages 25 to 38 form part of these financial statements.

For the year 
ended
30 June 2018 
£

For the year 
ended
30 June 2017
£

Note

3
5

6

(415,902)
–
(525,549)

(941,451)
–

(941,451)
97,033

(844,418)
–

(844,418)

(156,726)
(211,477)
(304,496)

(672,699)
(15,540)

(688,239)
42,685

(645,554)
–

(645,554)

14

(0.71)

(1.11)

22 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Statement of Financial Position 

As at 30 June 2018

ASSETS
Non-current assets
Intangible assets

Total non-current assets

Current assets
Other receivables
Corporation tax receivable
Cash and cash equivalents

Total current assets

Total assets

EQUITY AND LIABILITIES
Equity
Capital and reserves
Called up share capital
Share premium
Other reserves
Accumulated deficit

Total equity

Liabilities
Current liabilities
Trade and other payables

Total current liabilities

Total liabilities

Total equity and liabilities

As at 30 June
2018
£

As at 30 June
2017
£

Note

7

8
6, 8

11
11
13
13

9

287,672

287,672

93,421
86,272
3,182,898

3,362,591

3,650,263

215,412

215,412

151,189
42,685
3,922,903

4,116,777

4,332,189

1,187,085
3,577,640
170,418
(1,494,173)

1,187,085
3,577,640
98,559
(649,755)

3,440,970

4,213,529

209,293

209,293

209,293

118,660

118,660

118,660

3,650,263

4,332,189

These financial statements were approved and authorised for issue by the Board of Directors on 24 October 2018 and were signed on its
behalf by:

Doug Quinn
Director

Company Registration No. 09632164

The notes on pages 25 to 38 form part of these financial statements.

Statement of Cash Flows

For the Year Ended 30 June 2018

Cash flows from operating activities
Loss before tax for the period
Convertible loan interest paid as equity
Share option expenses

Changes in working capital
(lncrease)/decrease in trade and other receivables
Increase in trade and other payables

Cash generated by/(used in) operations

Taxation received

Net cash used in operating activities

Cash flows from investing activities
Payments for intangible assets

Net cash used in investing activities

Cash flows from financing activities
Net proceeds from issue of equity instruments of the Company
Net proceeds from issue of convertible loan notes

Net cash generated by financing activities

Net (decrease)/increase in cash and cash equivalents
Cash and cash equivalents at the beginning of the period

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  23

For the year 
ended
30 June 2018
£

For the year
ended
30 June 2017 
£

(941,451)
–
71,859

(869,592)

57,768
90,633

148,401

53,446

(688,239)
15,540
98,559

(574,140)

(120,582)
85,019

(35,563)

–

(667,745)

(609,703)

(72,260)

(72,260)

(79,198)

(79,198)

–
–

–

(740,005)
3,922,903

3,955,137
400,000

4,355,137

3,666,236
256,667

Cash and cash equivalents at the end of the period

3,182,898

3,922,903

The notes on pages 25 to 38 form part of these financial statements.

24 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Statement of Changes in Equity 

For the Year Ended 30 June 2018

As at 1 July 2016
Loss for the period
Issue of shares
Costs of share issue
Issue of convertible loan notes
Conversion of convertible loan notes
Share-based payments

As at 30 June 2017
Loss for the period
Issue of shares
Costs of share issue
Issue of convertible loan notes
Conversion of convertible loan notes
Share-based payments

Share 
capital
£

1,000
–
893,048
–
–
293,037
–

Share 
premium
£

393,048
–
3,606,952
(544,863)
–
122,503
–

1,187,085

3,577,640

–
–
–
–
–

–
–
–
–
–

Other 
reserves
£

Retained
earnings
£

–
–
–
–
93,151
(93,151)
98,559

98,559

–
–
–
–
71,859

(4,201)
(645,554)
–
–

–
–

(649,755)
(844,418)
–
–
–
–
–

Total
£

389,847
(645,554)
4,500,000
(544,863)
93,151
322,389
98,559

4,213,529
(844,418)
–
–
–
–
71,859

As at 30 June 2018

1,187,085

3,577,640

170,418

(1,494,173)

3,440,970

Share capital is the amount subscribed for shares at nominal value.

Share premium is the amount subscribed for share capital in excess of nominal value.

Other reserves arise from the equity element of a convertible loan issued and converted in the period to 30 June 2017, and from share options
granted on 5 April 2017.

Retained earnings represents accumulated profit or losses to date. 

The notes on pages 25 to 38 form part of these financial statements.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  25

Notes to the Financial Statements 

For the Year Ended 30 June 2018

General information

1
SkinBioTherapeutics plc is a public limited company incorporated in England under the Companies Act and quoted on the AIM market of
the London Stock Exchange (AIM: SBTX). The address of its registered office is given on page 1.

The principal activity of the Company is that of research and development into the effects of lysates derived from the human microbiome
on skin.

Significant accounting policies and basis of preparation

2
a) Statement of compliance
The Financial statements of SkinBioTherapeutics plc have been prepared in accordance with International Financial Reporting Standards
(‘IFRS’) as adopted by the European Union, IFRS Interpretations Committee (IFRIC) and the Companies Act 2006 applicable to companies
reporting under IFRS.

b) Basis of preparation 
The financial statements have been prepared under the historical cost convention modified by the revaluation of certain financial instruments.
The accounting policies have been applied consistently in all material respects.

The financial statements have been presented in Pounds Sterling (‘Sterling’) as this is the currency of the primary economic environment in
which the Company operates.

c) Going concern 
These financial statements have been prepared on a going concern basis. In considering the appropriateness of this assumption, the Board
has considered the Company’s projections for the twelve months from the date of approval of this financial information, including cash flow
forecasts. The directors believe that the Company has adequate resources to continue in operational existence for the foreseeable future
and therefore adopt the going concern basis of accounting in preparing these financial statements.

d) Estimates and judgements 
The preparation of financial statements requires the Board to make judgements, estimates and assumptions that may affect the application
of accounting policies and reported amounts of assets and liabilities as at each balance sheet date and the reported amounts of revenues
and expenses during each reporting period. Any estimates and assumptions are based on experience and any other factors that are believed
to be relevant under the circumstances and which the Board considers to be reasonable. Actual outcomes may differ from these estimates.
Any revisions to accounting estimates will be recognised in the period in which the estimate is revised if the revision affects only that period.
If the revision affects both current and future periods, the change will be recognised over those periods.

Certain accounting policies which have a significant bearing on the reported financial condition and results of the Company require subjective
or complex judgements. An example of such areas of judgement is the estimation of the lifetime of intangible assets, the capitalisation of
development costs and share based payments.

26 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

Significant accounting policies and basis of preparation continued

2
e) Application of new and revised International Financial Reporting Standards (IFRSs) 
No new standards or interpretations issued by the International Accounting Standards Board (‘IASB’) or the IFRS Interpretations Committee
(‘IFRIC’) have led to any material changes in the Company’s accounting policies or disclosures during each reporting period.

New and revised IFRSs in issue but not yet effective 
The Company has not applied the following new and revised IFRSs that have been issued but are not yet effective:

Reference

IFRS 2

IFRS 9

IFRS15

IFRS16

IFRS17

Title

Share-based 
payments

Summary

Amendments to classification and measurement
of share-based payment transactions

Financial instruments

Revised standard for accounting for 
financial instruments

Revenue from contracts 
with customers

Specifies how and when to recognise revenue 
from contracts as well as requiring more
information and relevant disclosures

Leases

Principles for the recognition, measurement,
presentation and disclosure of leases

Insurance contracts

Principles for the recognition, measurement,
presentation and disclosure of insurance

Application date of
standard (Periods
commencing on or after)

1 January 2018

1 January 2018

1 January 2018

1 January 2019

1 January 2021

The adoption of these Standards and Interpretations is not expected to have a material impact on the financial information of the Company
in the period of initial application when they come into effect.

Foreign currencies

f)
Transactions in foreign currencies are translated at the exchange rate ruling at the date of the transaction. Monetary assets and liabilities
denominated in foreign currencies at the balance sheet date are translated at the exchange rate ruling at that date. Foreign exchange differences
on translation are recognised in the income statement. Non-monetary assets and liabilities that are measured in terms of historical cost in a
foreign currency are translated using the exchange rate at the date of the transaction. Non-monetary assets and liabilities denominated in
foreign currencies that are stated at fair value are translated at foreign exchange rates ruling at the dates the fair value was determined.

g) Research and development
Research expenditure is written off to the statement of comprehensive income in the year in which it is incurred. Development expenditure
is written off in the same way unless the directors are satisfied as to the technical, commercial and financial viability of individual projects. In
this situation, the expenditure is deferred and amortised over the period during which the Company is expected to benefit.

Impairment testing of intangible assets 

h)
At the end of each reporting period, the Company reviews the carrying amounts of its intangible assets to determine whether there is any
indication that those assets have suffered an impairment loss. If any such indication exists, the recoverable amount of the asset is estimated
to determine the extent of the impairment loss (if any).

Intangible assets with indefinite useful lives are tested for impairment at least annually, and whenever there is an indication that the assets
may be impaired.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  27

Significant accounting policies and basis of preparation continued

2
i)
Tax 
Current tax 
The tax currently payable is based on taxable profit for the period. Taxable profit differs from ‘profit before tax’ as reported in the income
statement because of items of income or expense that are taxable or deductible in other periods and items that are never taxable or
deductible. The Company’s current tax is calculated using rates that have been enacted during the reporting period.

Deferred tax
Deferred tax is provided using the balance sheet liability method, providing for temporary differences between the carrying amounts of
assets and liabilities for financial reporting purposes and the amounts used for tax purposes. The amount of deferred tax provided is based
on the expected manner of realisation or settlement of the carrying amount of assets and liabilities, using tax rates enacted or substantively
enacted at the balance sheet date.

A deferred tax asset is recognised only if it can be regarded as more likely than not that there will be suitable taxable profits from which the
future reversal of the underlying temporary differences can be deducted.

Payroll expense and related contributions

j)
Wages, salaries, payroll tax, paid annual leave and sick leave, bonuses, and non-monetary benefits are accrued in the period in which the
associated services are rendered.

k) Share-based compensation 
The Company issues share based payments to certain directors and others providing similar services. The fair value of the employee and
suppliers services received in exchange for the grant of the options is recognised as an expense. The total amount to be expensed over the
vesting year is determined by reference to the fair value of the options granted, excluding the impact of any non-market vesting conditions
(for example, profitability and sales growth targets). Nonmarket vesting conditions are included in assumptions about the number of options
that are expected to vest. At each statement of financial position date, the entity revises its estimates of the number of options that are
expected to vest. It recognises the impact of the revision to original estimates, if any, in the income statement, with a corresponding
adjustment to equity.

The proceeds received net of any directly attributable transaction costs are credited to share capital (nominal value) and share premium
when the options are exercised.

The fair value of share-based payments recognised in the income statement is measured by use of the Black Scholes model, which takes
into account conditions attached to the vesting and exercise of the equity instruments. The expected life used in the model is adjusted;
based on management’s best estimate, for the effects of non-transferability, exercise restrictions and behavioural considerations. The share
price volatility percentage factor used in the calculation is based on management’s best estimate of future share price behaviour and is
selected based on past experience, future expectations and benchmarked against peer companies in the industry.

Financial assets and liabilities 

l)
Financial assets and liabilities are recognised when the Company unconditionally becomes a party to the contractual terms of the instrument.
Unless otherwise indicated, the carrying amounts of financial assets and liabilities are considered by the directors to be a reasonable estimate
of their fair values at each balance sheet date.

Financial assets include trade and other receivable; these are classified as loans and receivables. Financial liabilities include trade and other
payables, convertible loan notes and borrowings; these are classified as other financial liabilities carried at amortised cost.

Classification as debt or equity
Debt and equity instruments issued by the Company are classified as either financial liabilities or as equity in accordance with the substance
of the contractual arrangements and the definitions of a financial liability and an equity instrument.

Equity instruments
An equity instrument is any contract that evidences a residual interest in the assets of an entity after deducting all of its liabilities. Equity
instruments issued by the Company are recognised as the proceeds received, net of direct issue costs.

28 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

Financial assets and liabilities continued 

Significant accounting policies and basis of preparation continued

2
l)
Compound instruments
The component parts of compound instruments (convertible notes) issued by the Company are classified separately as financial liabilities
and equity in accordance with the substance of the contractual arrangements and the definitions of a financial liability and an equity
instrument.

At the date of issue, the fair value of the liability component is estimated using the prevailing market interest rate for similar non-convertible
instruments. The amount is recorded as a liability on an amortised cost basis using the effective interest method until extinguished upon
conversion or at the instrument’s maturity date.

The conversion option classified as equity is determined by deducting the amount of the liability component from the fair value of the
compound instrument as a whole. This is recognised and included in equity, net of income tax effects, and is not subsequently remeasured.
In addition, the conversion option classified as equity will remain in equity until the conversion option is exercised, in which case, the balance
recognised in equity will be transferred to share premium. When the conversion option remains unexercised at the maturity date of the
convertible notes, the balance recognised in equity will be transferred directly to retained earnings. No gain or loss is recognised in profit or
loss upon conversion or expiration of the conversion option.

Transaction costs that relate to the issue of the convertible notes are allocated to the liability and equity components in proportion to the
allocation of gross proceeds. Transaction costs relating to the equity component are recognised directly in equity. Transaction costs relating
to the liability component are included in the carrying amount of the liability component and are amortised over the lives of the convertible
notes using the effective interest method

Derecognition 
Financial assets are derecognised when rights to receive cash flows from the assets expire or, the financial assets are transferred and the
Company has transferred substantially all the risks and rewards of ownership of the financial assets. On derecognition of a financial asset, the
difference between the asset’s carrying amount and the sum of the consideration received and receivable and the cumulative gain or loss
that had been recognised in other comprehensive income and accumulated in equity is recognised in profit or loss.

Financial liabilities are derecognised when the obligation specified in the relevant contract is discharged, cancelled or expires. The difference
between the carrying amount of the financial liability derecognised and the consideration paid and payable is recognised in profit or loss.

When the terms of a financial liability are renegotiated and result in the Company issuing equity instruments to a creditor of the Company
to extinguish all or part of the financial liability, the Company recognises the issue of equity instruments at their fair values. Any difference
between the fair value of the equity instruments and the carrying amount of the financial liability to be extinguished is recognised in the
income statement.

Trade and other receivables 
Trade and other receivables are recognised initially at their fair value and subsequently at their amortised cost using the effective interest
method, less provision for impairment. If there is objective evidence that the recoverability of the asset is at risk, appropriate allowances for
any estimated irrecoverably amounts are recognised in the income statement.

Trade and other payables 
Trade and other payables are recognised initially at their fair value, net of transaction costs, and subsequently at their amortised cost using
the effective interest method.

Cash and cash equivalents 
Cash and cash equivalents comprise cash in hand.

Borrowing and finance charges 
Bank borrowings are initially recognised at their fair value, net of any transaction cost directly attributable to their issue. Subsequently bank
borrowings are carried at their amortised carrying value using the effective interest method.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  29

Significant accounting policies and basis of preparation continued

2
m) Financial risk management 
Risk management objectives 
Management identify and evaluate financial risks on an on-going basis. The principal risks to which the Company is exposed are market risk
(including interest rate risk, and cash flow risk), credit risk, and liquidity risk.

Market risk
Market risk is defined as the risk that the fair value of future cash flows of a financial instrument will fluctuate because of changes in market
prices. The Company’s market risks arise from open positions in (a) interest-bearing assets and liabilities, and (b) foreign currencies; to the
extent that these are exposed to general and specific market movements (see details below).

Interest rate risk
The Company’s interest-bearing assets comprise of only cash and cash equivalents. As the Company’s interest-bearing assets do not generate
significant amounts of interest; changes in market interest rates do not have any significant direct effect on the Company’s income.

Currency risk
The Company is exposed to movement in foreign currency exchange rates arising from normal trading transactions that are denominated
in currencies other than the respective functional currencies of the Company. The Company does not have a policy to hedge its exposure
to foreign currency exchange risk as currently overseas transactions are only a small percentage of total transactions and fluctuations in
foreign currencies are not expected to significantly affect the Company’s total transactions. In future the Company may consider hedging its
exposure to foreign currency exchange risk.

Credit risk
Credit risk refers to the risk that a counterparty will default on its contractual obligations resulting in financial loss to the Company. Credit risk
arises from cash balances (including bank deposits, cash and cash equivalents) and credit exposures to trade receivables. The Company’s
maximum exposure to credit risk is represented by the carrying value of cash and cash equivalents and trade receivables.

Credit risk is managed by monitoring clients and performing credit checks before accepting any customers.

Liquidity risk
Liquidity risk is the risk that the Company may encounter difficulty in meeting its obligations associated with financial liabilities that are
settled by delivering cash or other financial assets.

The Company seeks to manage its liquidity risk by ensuring that sufficient liquidity is available to meet its foreseeable needs.

n) Capital management
The Company manages its capital to ensure that it will be able to continue as a going concern while maximising the return to stakeholders.
The Company’s overall strategy remained unchanged during the period.

The capital structure of the Company consists of cash and cash equivalents, issued capital, the share premium account, the share-based
compensation reserve resulting from the grant of equity-settled share options to selected directors and others providing similar services,
and retained earnings.

The Company is not subject to any externally imposed capital requirements.

As part of the Company’s management of capital structure, consideration is given to the cost of capital.

30 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

3

Operating loss

An analysis of the Company’s operating loss has been arrived at after charging/(crediting):
Other income
Research and development
Directors remuneration (including share-based compensation)*
Auditors remuneration

– audit fees
– other services

Foreign exchange differences
Other operating costs
Initial public offering costs

Total operating expenses

30 June 2018
£

30 June 2017
£

(84)
415,902
212,541

10,995
1,750
345
300,002
–

941,451

(5)
156,726
38,881

14,000
11,049
69
240,502
211,477

672,699

* Excludes directors remuneration included within research and development.

The Company has one reportable segment, namely the research and development of the SkinBiotix® technology, all within the United
Kingdom.

Employees and directors

4
The average monthly number of employees and senior management was:

Executive directors
Non-executive directors
Employees

Average total persons employed

As at 30 June 2018 the Company had 6 employees (30 June 2017:5).

Staff costs in respect of these employees were:

Wages and salaries
Social security costs
Defined contribution pensions
Share-based payments (see note 12)

Total remuneration

30 June 2018
Number

30 June 2017
Number

2
3
1

6

2
2
-

4

30 June 2018
£

30 June 2017
£

85,347
1,799
427
71,859

159,432

37,784
1,986
-
15,469

55,239

Some of these staff costs are included within research and development.

All the directors above can be considered to be key management and have the responsibility for planning, directing and controlling, directly
or indirectly, the activities of the Company.

The remuneration of directors and key executives is determined by the Remuneration Committee having regard to the performance of
individuals and market trends.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  31

Employees and directors continued

4
The Company operates a defined contribution pension scheme for employees and directors. The assets of the scheme are held separately
from those of the Company in independently administered funds. The amounts outstanding at 30 June 2018 are £841 (2017: nil).

Directors remuneration:

Prof Catherine O’Neill
Doug Quinn
Dr Cathy Prescott
Martin Hunt
Stephen O’Hara

Total remuneration

The highest paid director received total emoluments of £85,022 during the year.

5

Finance cost

Interest payable on loan notes

Total finance cost

Taxation

6
Income taxes recognised in profit or loss

Current tax
Current period – UK corporation tax
R&D tax credit
R&D tax credit - prior year

Tax credit for the year

30 June 2018
£

30 June 2017
£

64,763
85,022
20,083
54,703
20,084

244,655

38,782
7,156
7,301
1,000
1,000

55,239

30 June 2018
£

30 June 2017
£

–

–

15,540 

15,540

30 June 2018
£

30 June 2017
£

–
86,272
10,761

97,033

–
42,685
-

42,685

The tax charge for each period can be reconciled to the loss per the statement of comprehensive income as follows:

Loss on ordinary activities before tax
Normal applicable rate of tax
Loss on ordinary activities multiplied by normal rate of tax

Effects of:
Disallowables
R&D enhanced deductions
R&D tax credit
Losses surrendered
Unused tax losses carried forward

UK tax charge/(credit)

(941,451)
19.00%
(178,876)

(688,239)
19.75%
(135,927)

17,180
(63,895)
(97,033)
113,046
112,545

(97,033)

42,404
(32,861)
(42,685)
58,140
68,245

(42,685)

The Company has an unrecognised deferred tax asset of £173,344 at the period end, which has not been recognised in the financial statements
due to uncertainty of future profits. The Company has an estimated tax loss of £912,336 available to be carried forward against future profits.

32 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

7

Intangible assets

Cost
At 1 July 2016
Additions

At 30 June 2017
Additions

At 30 June 2018

Accumulated amortisation 
At 1 July 2016
Charge for the period

At 30 June 2017
Charge for the period

At 30 June 2018

Net book value 
At 1 July 2016

At 30 June 2017

At 30 June 2018

Intellectual property is to be amortised over the expected period that the asset generates income.

8

Trade and other receivables

Prepayments
Corporation tax
VAT recoverable
Other receivables

Intellectual
property
£

136,214
79,198

215,412
72,260

Total
£

136,214
79,198

215,412
72,260

287,672

287,672

–
–

–
–

–

–
–

–
–

–

136,214

215,412

136,214

215,412

287,672

287,672

30 June 2018
£

30 June 2017
£

27,185
86,272
66,086
150

179,693

39,726
42,685
111,463
–

193,874

The fair values of the Company’s trade and other receivables are considered to equate to their carrying amounts. The maximum exposure to
credit risk for trade receivables is represented by their carrying amount. There are no financial assets which are past due but not impaired. No
financial assets are impaired.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  33

9

Trade and other payables

Current
Trade creditors
Accruals
Other taxes
Other payables

30 June 2018
£

30 June 2017
£

130,534
72,842
1,835
4,082

209,293

85,412
29,996
1,733
1,519

118,660

Trade and other payables principally consist of amounts outstanding for trade purchases and ongoing costs. They are non-interest bearing and
are normally settled on 30-day terms. The directors consider that the carrying value of trade and other payables approximates to their fair value.
All trade and other payables are denominated in Sterling. The Company has financial risk management policies in place to ensure that all payables
are paid within the credit timeframe and no interest has been charged by any suppliers as a result of late payment of invoices during the period.

The fair value of trade and other payables approximates their current book values.

10 Financial instruments 

Maturity analysis 
A summary table with maturity of financial assets and liabilities presented below is used by management to manage liquidity risks. The
amounts disclosed in the following tables are the contractual undiscounted cash flows. Undiscounted cash flows in respect of balances due
within 12 months generally equal their carrying amounts in the statement of financial position, as the impact of discounting is not material.

The maturity analysis of financial instruments at 30 June 2018 is as follows:

Assets
Cash and cash equivalents
Trade and other receivables

Liabilities
Trade and other payables
Borrowings

On demand
Carrying and less than
3 months
amount
£
£

3 to 12
months
£

1 to 2 years
£

2 to 5 years
£

3,182,898
179,693

3,182,898
179,693

3,362,591

3,362,591

209,293
–

209,293

209,293
–

209,293

–
–

–

–
–

–

–
–

–

–
–

–

–
–

–

–
–

–

34 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

10 Financial instruments continued

Maturity analysis continued
The maturity analysis of financial instruments at 30 June 2017 is as follows:

Assets
Cash and cash equivalents
Trade and other receivables

Liabilities
Trade and other payables
Borrowings

11 Share capital

Issued and fully paid

As at 30 June 2016
Bonus issue of £0.01 ordinary shares
Issued on loan note conversion
Issued under placing agreement
Costs related to shares issued under placing agreement

As at 30 June 2017

As at 30 June 2018

On demand
Carrying and less than
3 months
amount
£
£

3 to 12
months
£

1 to 2 years
£

2 to 5 years
£

3,922,903
193,874

3,922,903
193,874

4,116,777

4,116,777

118,660
–

118,660

118,660
–

118,660

–
–

–

–
–

–

–
–

–

–
–

–

–
–

–

–
–

–

Number

Share capital Share premium
£

£

100,000
39,304,800
29,303,694
50,000,000
–

1,000
393,048
293,037
500,000
–

393,048
(393,048)
122,503
4,000,000
(544,863)

118,708,494

1,187,085

3,577,640

118,708,494

1,187,085

3,577,640

Share capital is the amount subscribed for shares at nominal value, issued and fully paid.

Share premium is the amount subscribed for share capital in excess of nominal value.

The issued ordinary shares carry one voting right per share and do not carry any rights to fixed income.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  35

12 Share-based payments 

Share options
The Company operates share-based payment arrangements to remunerate directors and others providing similar services in the form of a
share option scheme. The exercise price of the option is normally equal to the market price of an ordinary share in the Company at the date
of grant. Each share option converts into one ordinary share of the Company on exercise. No amounts are paid or payable by the recipient
on receipt of the option. The options carry neither rights to dividends nor voting rights.

Movements in the number of share options outstanding and their related weighted average exercise prices are as follows:

Outstanding at 1 July
Granted during the year
Forfeited/cancelled during the year

Outstanding at 30 June

30 June 2018

30 June 2017

Weighted
average
exercise
price
£

Number of
options

0.09
–
–

0.09

–
11,027,565
–

11,027,565

Weighted
average
exercise
price
£

–
0.09
–

0.09

Number of
options

11,027,565
–
–

11,027,565

On 5 April 2017, 5,189,442 options were granted at an exercise price of £0.09 per share and are exercisable based upon achieving any one of
three performance conditions. The performance conditions are based on the commercial viability of developed products, or the entering
into of joint ventures, partnerships, collaborations or agreements for the sale or licensing of products.

On 5 April 2017, 5,189,443 options were granted at an exercise price of £0.09 per share and are exercisable based upon achieving either of
two market conditions. These market conditions are based on the achievement of an 18p share price for more than a 30-day continuous
period, or a qualifying exit with a share price of not less than 18p.

On 5 April 2017, 648,680 options were granted at an exercise price of £0.09 per share and are exercisable based upon achieving three
performance conditions by 30 September 2017. Vesting conditions dictate that some of the options will vest for each of the performance
conditions achieved. Performance conditions include achieving targets involving proofs of principles, proof of concepts and prototype
formulations. The conditions are not dependent on each other and will vest separately.

On 30 June 2018 the exercise date of the 648,680 options in pool 3 was extended to 31 December 2019. The fair value was recalculated
based on the original valuation with the new exercise date, and then the additional fair value added due to the extension charged to the
statement of comprehensive income over the extended period.

The fair values of the share options issued in the year were derived using the Black Scholes model. The total charge recognised for the year
ended 30 June 2018 for share options is £71,859 (2017: £18,431). The following assumptions were used in the calculations:

Deed pool
Grant date
Exercise price
Share price at grant date
Risk-free rate
Volatility
Expected life
Fair value

1
05/04/17
9p
9p
0.24%
60%
3.5 years
2.58p

2
05/04/17
9p
9p
0.24%
60%
3.5 years
1.85p

3a
05/04/17
9p
9p
0.05%
60%
2.75 years
2.30p

3b
05/04/17
9p
9p
0.05%
60%
2.75 years
2.30p

3c
05/04/17
9p
9p
0.05%
60%
2.75 years
2.30p

36 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

12 Share-based payments continued
The closing share price per share at 30 June 2018 was 14.50p (30 June 2017: 10.13p)

Expected volatility is based on a conservative estimate for an AIM listed entity. The expected life used in the model has been adjusted, based
on management’s best estimate, for the effects of non-transferability, exercise restrictions and behavioural considerations.

Warrants 
On 29 March 2017 the Company executed a warrant agreement to create and issue warrants to the Company’s nominated adviser Cairn
Financial Advisers LLP to subscribe for 890,314 ordinary shares of £0.01 for a cost of £0.09 per ordinary share. The warrants are exercisable for
a period of 5 years through until 5 April 2022. No warrants have yet been subscribed to.

The Company has accounted for the charge arising from the issue of warrants as below:

The total charge recognised for the year ended 30 June 2018 for warrants is nil, as the entire fair value of £80,128 had been released in 2017.
The fair values of the warrants granted have been estimated at cost as the warrants are available immediately and are unconditional.

13 Reserves

As at 10 June 2015
Issue of convertible loan notes
Conversion of convertible loan notes
Issue of share options
Loss for the period

As at 30 June 2017
Issue of share options
Loss for the period

As at 30 June 2018

Other
reserves
£

–
93,151
(93,151)
98,559
-

98,559
71,859
-

Retained 
earnings
£

(4,201)
–
–
–
(645,554)

(649,755)
-
(844,418)

Total
£

(4,201)
93,151
(93,151)
98,559
(645,554)

(551,196)
71,859
(844,418)

170,418

(1,494,173)

(1,323,755)

Other reserves arise from the equity element of the convertible loan (see note 15) and share-based payments (see note 12).

Retained earnings represents accumulated profit or losses to date.

14 Loss per share

Basic and diluted loss per share
Loss after tax (£)
Weighted average number of shares
Basic and diluted loss per share (pence)

30 June 2018
£

30 June 2017
£

(844,418)
118,708,494
(0.71)

(645,554)
58,307,324
(1.11)

As the Company is reporting a loss from continuing operations for the year then, in accordance with IAS 33, the share options are not
considered dilutive because the exercise of the share options would have an anti-dilutive effect. The basic and diluted earnings per share as
presented on the face of the income statement are therefore identical.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  37

15 Convertible loans
On 31 October 2016, the Company drew down a loan of £400,000 (“Loan”) under a term loan facility agreed on 13 October 2016 with its
parent company to fund its ongoing working capital requirements. The Loan was unsecured, bearing interest at a rate of 5% per annum,
and repayable in full on 30 September 2020. The Loan was converted into 1 ordinary share in the Company for every £0.01365 of the Loan
prior to admission to AIM on 5 April 2017.

Value of liability component and equity conversion component 
The values of liability component and equity conversion component were determined at issuance of the convertible loan. The liability
component of the Loan was calculated using a market interest rate for an equivalent non-convertible loan with effective interest rates of
12% at initial recognition. The residual amount, representing the value of the equity conversion component, was included and presented in
equity under the heading of “other reserves”.

Proceeds of issue
Liability component at the date of issue

Equity component

£

400,000
(306,849) 

93,151

Conversion 
The effective interest was calculated immediately prior to conversion and recognised in the Statement of Comprehensive Income, and the
remaining liability component of the Loan converted to equity.

Liability component at the date of issue
Interest charged up to conversion date at an effective interest rate of 12%
Interest paid

Liability component immediately before conversion on 5 April 2017

Liability component immediately before conversion on 5 April 2017
Equity component

Total converted to equity

£

306,849
15,540
–

322,389

£

322,389
93,151

415,540

Share
Premium
£

Number
£

Share Capital
£

Equity converted into:

29,303,694

293,037

122,503

38 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to the Financial Statements (continued)

For the Year Ended 30 June 2018

16 Related party transactions
During the period ended 30 June 2018, the Company was charged fees of £48,803 and travel expenses of £70 by Quinn Corporate Services
Ltd, a company in which Doug Quinn, a director of the Company, is also a director. These fees relate to Doug Quinn’s consultancy services
to the Company. As at 30 June 2018 £4,000 was outstanding.

During the period ended 30 June 2018, the Company was charged fees of £24,068 and travel expenses of £812 by Invictus Management Ltd,
a company in which Martin Hunt, a director of the Company, is also a director. These fees relate to Martin Hunt’s consultancy services to the
Company. As at 30 June 2018 £2,068 was outstanding.

During the period ended 30 June 2018, the Company was charged fees of £12,000 by Biolatris Ltd, a company in which Dr Cathy Prescott, a
director of the Company, is also a director. These fees relate to Dr Cathy Prescott’s consultancy services to the Company. As at 30 June 2018
nil was outstanding.

During the period ended 30 June 2018, the Company was charged fees of £20,000 by Intelligent Biotech Ltd, a company in which Stephen
O’Hara, a director of the Company, is also a director. These fees relate to Stephen O’Hara’s consultancy services to the Company. As at 30 June
2018 nil was outstanding.

17 Ultimate controlling party
No one shareholder has control of the Company.

18 Events after the reporting date
The Company has evaluated all events and transactions that occurred after 30 June 2018 up to the date of signing of the financial statements.

No material subsequent events have occurred that would require adjustment to or disclosure in the financial statements.

SkinBioTherapeutics plc Annual Report & Accounts 2018  |  39

Notice of 2018 Annual General Meeting

SKINBIOTHERAPEUTICS PLC (the “Company”)
(Registered in England and Wales with company number 09632164)

NOTICE IS HEREBY GIVEN THAT the Annual General Meeting of the above-named company will be held at 111 PICCADILLY, MANCHESTER,
M1 2HY on 19 November 2018 at 11:00 AM for the transaction of the following business:

Ordinary Business
To consider, and if thought fit, to pass the following resolutions 1 to 4 as ordinary resolutions:

1.        THAT the directors’ and auditors’ reports and the financial statements for the financial year ended 30 June 2018 be received and

adopted.

2.        THAT Jeffreys Henry be re-appointed as the auditors of the Company until the next Annual General Meeting and the directors be

authorised to fix their remuneration.

3.        THAT Douglas Quinn, who retires in accordance with the Articles of Association of the Company, be re-elected as a director of the

Company.

4.        THAT Catherine Prescott, who retires in accordance with the Articles of Association of the Company, be re-elected as a director of the

Company.

Special Business
To consider and, if thought fit, to pass the resolutions set out below, of which resolution 5 will be proposed as an ordinary resolution and
resolution 6 will be proposed as special resolutions:

5.        THAT the directors be generally and unconditionally authorised pursuant to Section 551 of the Companies Act 2006 (the “Act”) to allot
relevant securities (within the meaning of that section) up to one third of the existing share capital of the Company being an aggregate
nominal amount of £395,694.98. The authority referred to in this resolution shall be in substitution for all other existing authorities, and
shall expire (unless previously renewed, varied or revoked by the Company in general meeting) at the conclusion of the next Annual
General Meeting of the Company. The Company may, at any time prior to the expiry of the authority, make an offer or agreement
which would or might require relevant securities to be allotted after the expiry of the authority and the directors are hereby authorised
to allot relevant securities in pursuance of such offer or agreement as if the authority had not expired.

6.

THAT the directors, pursuant to Section 570 of the Act, be empowered to allot equity securities (within the meaning of Section 560 of
the Act) for cash pursuant to the authority conferred by Resolution 5 as if Section 561(1) of the Act did not apply to any such allotment
provided that this power shall be limited to:

(a)

the allotment of equity securities where such securities have been offered (whether by way of a rights issue, open offer or
otherwise) to the holders of ordinary shares in the capital of the Company in proportion (as nearly as maybe) to their holdings
of such ordinary shares but subject to such exclusions or other arrangements as the directors may deem necessary or expedient
to deal with equity securities representing fractional entitlements and with legal or practical problems under the laws of, or the
requirements of, any regulatory body or any stock exchange in, any territory; and

(b)

the allotment, other than pursuant to (a) above, of equity securities:

(i)

(ii)

arising from the exercise of options and warrants outstanding at the date of this resolution; and

including any issue pursuant to (i) above, up to one third of the existing share capital of the Company up to an aggregate
nominal value of £395,694.98,

and this power shall, unless previously revoked or varied by special resolution of the Company in general meeting, expire at the
conclusion  of  the  next  Annual  General  Meeting  of  the  Company.  The  Company  may,  before  such  expiry,  make  offers  or
agreements which would or might require equity securities to be allotted after such expiry and the directors are hereby
empowered to allot equity securities in pursuance of such offers or agreements as if the power conferred hereby had not expired.

By order of the Board

Douglas Quinn                                                                                                                                                                                                Registered Office
15 Silk House
Company Secretary
Park Green 
                                                                                                                                                                                                                                     Macclesfield 
Dated 25 October 2018                                                                                                                                                                                                  England
                                                                                                                                                                                                                                           SK11 7QJ 

40 |  SkinBioTherapeutics plc Annual Report & Accounts 2018

Notes to Notice of 2018 Annual General Meeting

1.

In accordance with Regulation 41 of the Uncertificated Securities Regulations 2001 and by paragraph 18(c) of The Companies Act (Consequential Amendments) (Uncertificated
Securities) Order 2009, only those members entered on the Company’s register of members not later than 11:00 am on 16 November 2018, or if the meeting is adjourned,
Shareholders entered on the Company’s register of members not later than 2 days before the time fixed for the adjourned meeting (excluding non-business days) shall be
entitled to attend and vote at the meeting.

2. A member of the Company entitled to attend and vote at this meeting is entitled to appoint a proxy (or proxies) to attend, speak and vote in his place. A proxy need not be a

member of the Company. You can only appoint a proxy using the procedures set out in these notes and the notes to the Form of Proxy.

3.

4.

5.

To be effective, the Form of Proxy must be deposited at the office of the Company’s registrars, Share Registrars Limited, The Courtyard, 17 West Street, Farnham, GU9 7DR so as
to be received not later than 11:00 am on 16 November 2018, or if the meeting is adjourned, not later than 48 hours before the time fixed for the adjourned meeting.

To change your proxy instructions simply submit a new proxy appointment using the methods set out above and in the notes to the Form of Proxy. Note that the cut-off times
for receipt of proxy appointments (see above) also apply in relation to amended instructions; any amended proxy appointment received after the relevant cut-off time will be
disregarded.

Where you have appointed a proxy, and would like to change the instructions, please contact the Share Registrars Limited, The Courtyard, 17 West Street, Farnham, GU9 7DR.

In order to revoke a proxy instruction, you will need to inform the Company by sending a signed hard copy notice clearly stating your intention to revoke your proxy appointment
to the Company’s registrars, Share Registrars Limited, The Courtyard, 17 West Street, Farnham, GU9 7DR. In the case of a member which is a company, the revocation notice
must be executed under its common seal or signed on its behalf by an officer of the Company or an attorney for the Company. Any power of attorney or any other authority
under which the revocation notice is signed (or a duly certified copy of such power or authority) must be included with the revocation notice.

In either case, the revocation notice must be received by the Company’s registrars, Share Registrars Limited, The Courtyard, 17 West Street, Farnham, GU9 7DR 11:00 am on
16 November 2018. If you attempt to revoke your proxy appointment but the revocation is received after the time specified above, then your proxy appointment will remain
valid. Appointment of a proxy does not preclude you from attending the Meeting and voting in person. If you have appointed a proxy and attend the Meeting in person, your
proxy appointment will automatically be terminated.

6.  CREST members who wish to appoint a proxy or proxies by utilising the CREST electronic proxy appointment service may do so for the General Meeting and any adjournment(s)
thereof by utilising the procedures described in the CREST Manual. CREST Personal Members or other CREST sponsored members, and those CREST members who have appointed
a voting service provider(s), should refer to their CREST sponsor or voting service provider(s), who will be able to take the appropriate action on their behalf.

In order for a proxy appointment made by means of CREST to be valid, the appropriate CREST message (a ‘CREST Proxy Instruction’) must be properly authenticated in accordance
with Euroclear UK & Ireland Limited’s specifications and must contain the information required for such instructions, as described in the CREST Manual. The message, regardless
of whether it relates to the appointment of a proxy or to an amendment to the instruction given to a previously appointed proxy must, in order to be valid, be transmitted so
as to be received by our agent Share Registrars Limited (ID 7RA36) no later than 11:00 am on 16 November 2018 or, if the meeting is adjourned, 48 hours before the time fixed
for the adjourned meeting (excluding any part of a day that is not a working day). For this purpose, the time of receipt will be taken to be the time (as determined by the
timestamp applied to the message by the CREST Applications Host) from which the issuer’s agent, Share Registrars Limited, is able to retrieve the message by enquiry to CREST
in the manner prescribed by CREST. After this time, any change of instructions to proxies appointed through CREST should be communicated to the appointee through other
means. The Company may treat as invalid a CREST Proxy Instruction in the circumstances set out in Regulation 35(5)(a) of the Uncertificated Securities Regulations 2001.

CREST members and, where applicable, their CREST sponsors or voting service providers should note that Euroclear UK & Ireland Limited does not make available special
procedures in CREST for any particular messages. Normal system timings and limitations will therefore apply in relation to the input of CREST Proxy Instructions. It is the
responsibility of the CREST member concerned to take (or, if the CREST member is a CREST personal member or sponsored member or has appointed a voting service provider(s),
to procure that his CREST sponsor or voting service provider(s) take(s)) such action as shall be necessary to ensure that a message is transmitted by means of the CREST system
by any particular time. In this connection, CREST members and, where applicable, their CREST sponsors or voting service providers are referred, in particular, to those sections of
the CREST Manual concerning practical limitations of the CREST system and timings.

Perivan Financial Print    251893

Contents

Statutory and Other Information

Chairman’s Statement

Strategic and Financial Review

Directors’ Report

Corporate Governance Report

Independent Auditor’s Report to the 
Members of SkinBioTherapeutics plc

Statement of Comprehensive Income

Statement of Financial Position

Statement of Cash Flows

Statement of Changes in Equity

Notes to the Financial Statements

Notice of Annual General Meeting

Notes to the Annual General Meeting Notice

1

2

3

7

9

18

21

22

23

24

25

39

40

Annual Report and Financial Statements
For the Year Ended 30 June 2018 

SkinBioTherapeutics plc

Company Registration Number: 09632164

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15 Silk House, Park Green, Macclesfield, SK11 7QJ