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Alliance Pharma

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FY2015 Annual Report · Alliance Pharma
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2015 Annual Report
and Accounts

Contents

Business Summary*

01  Business and Financial Highlights 

02  Our Business Model

04  Sinclair Acquisition

06 Growth through International Expansion

08  Corporate Development

09 Growth through Acquisitions

10  Promoted Brands

13  Development of the Organisation

Report of the Directors

14  Strategic Report

18  Board of Directors

20 Corporate Governance

22  Directors’ Remuneration

24  Other Matters

Financial Statements

26  Independent Auditor’s Report to the Members of 
      Alliance Pharma plc

27  Consolidated Income Statement

28  Consolidated Statement of Comprehensive Income

29  Consolidated Balance Sheet

30 Company Balance Sheet

31  Consolidated Statement of Changes in Equity

32  Company Statement of Changes in Equity

33  Consolidated and Company Cash Flow Statements

34  Notes to the Financial Statements

Alliance Pharma 
plc is an AIM 
listed specialty
pharmaceutical
company

Alliance, commencing trade in 1998, is an

international specialty pharmaceutical

company based in Chippenham, Wiltshire,

UK. The Company has sales in more than 

100 countries worldwide via direct sales,

joint ventures and a network of distributors.

Alliance has a strong track record of

acquiring the rights to established niche

Supplementary Information*

products and it currently owns or licenses the

68  Shareholder Information

69  Shareholder Analysis

70 Five Year Summary

71  Advisors

*Unaudited information.

rights to approximately 90 pharmaceutical

and consumer healthcare products. The

Company continues to explore opportunities

to expand its product portfolio.

      
 
 
 
Alliance Pharma plc | Annual Report 2015 01

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Key Facts

Transformational Sinclair
Healthcare Products Business
acquisition in December 2015

MacuShield acquisition in
February 2015, used in Age-
related Macular Degeneration
(‘AMD’), contributed £3.5m to
revenue in 2015 and provides 
an exciting international 
growth opportunity

Licensing agreement signed 
with Duchesnay Inc. in January
2015 for the product Diclectin

Revenue up 11% at £48.3m 
(2014: £43.5m), including £0.8m
from the acquisition of the
Sinclair Healthcare Products
Business

Hydromol continues to
demonstrate good growth,
achieving year on year sales
growth of 10% to £6.6m

Settlement received of £6.3m 
(net of fees) in connection with
ImmuCyst claim

Full year dividend up 10% to
1.100p per share (2014: 1.000p)

Business and Financial Highlights

Key Numbers

Sales
£48.3m

Profit Before Tax*
£11.4m

Dividend
1.100p

Free Cash Flow
£6.3m

EPS - Basic*
3.69p

2015

48.3m

2014

43.5m

2015* 11.4m

2014*

10.8m

2015

1.100p

2014

1.000p

2015

6.3m

2014

10.3m

2015* 3.69p

2014* 3.36p

*Before non-underlying items, being primarily compensation from Sanofi and acquisition costs for the 
Sinclair Healthcare Products Business in 2015 and Pavacol-D impairment in 2014.

 
02 Alliance Pharma plc | Annual Report 2015        

Our Business Model

Strategy

Alliance’s principal activities are the acquisition or inward licensing of
established and marketed products with stable sales or growth potential, and 
the marketing of those products. Its manufacturing, storage and logistics are
controlled by Alliance but outsourced to leading specialist organisations in 
these fields. It does not engage in R&D, but does undertake modest development
on line extensions.

The acquired products have a market position which has been
long established by their previous owners. Where necessary,
Alliance ensures the product’s viability by regulatory and
technical initiatives so that the established franchise can be
relied upon to provide sustainable cash-flow into the
foreseeable future.

Certain products are assessed for their potential to respond to
promotional investment. If promotion would produce an
economic return, then it is implemented via Alliance’s
specialised sales and marketing operation.

Corporate growth is further enhanced by licensing in and
marketing products that have been developed by other
companies’ R&D activities. 

The acquisition of products is typically financed by a 
combination of bank debt and equity in a ratio that optimises
earnings per share whilst maintaining acceptable levels of
gearing. Surplus cash generated after providing for debt
servicing and the operational needs of the business is then
available for dividend payments.

Operational Business Model

Finance

Portfolio
management
(c. 90
products)

Commercial
&
Marketing

Supply
Chain &
Operations

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HR & IT

Regulatory

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D

 
 
 
 
Alliance Pharma plc | Annual Report 2015 03

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Three Pillars
Our promoted portfolio is focused on
three key areas: Dermatology; Mother
and Child; and Ophthalmology.

The promotion of these pillars is
supported by our bedrock of non-
promoted products.

These are good, stable products that
continue to meet medical needs and
require limited to no promotion in
order to sustain their sales.

They provide considerable cash
generation to support the growth
activities of these three pillars, and
also assist in the financing of
acquisitions.

52% Other (90 products)

9% Kelo-cote

8% Flamma

7% Hydromol

5% Aloclair

4% MacuShield

4% Haemopressin

4% Forceval

4% Optiflo

3% Oxyplastine

Balanced Portfolio

16%*%*%
Mother & Child
Kelo-stretch, Forceval/
Fushifu, Suprememil, 
Ashton & Parsons, Anbesol,
Alovex, Syntometrine,
MolluDab, Timodine,
Oxyplastine
Oxyplastine

32%*%*%
Dermatology
Kelo-cote,
Hydromol,
Flammazine/
Flammacerium
Aloclair,
Atopiclair, 
Lypsyl

4%*%*%
Ophthalmology
MacuShield
M Shi ld

48%*%*%

The Bedrock:
Core portfolio of non-promoted products.

Risk Reduction through Diversity
Any potential risk is spread across a portfolio of around 90 products, the largest
representing under 10% of Alliance’s sales.*

Risk Reduction Through Diversity

*Percentages refer to pro forma sales in the 12 months to 31 December 2015, including share of Joint Ventures.

 
04 Alliance Pharma plc | Annual Report 2015        

Sinclair Acquisition

Transformational acquisition launches a 
new stage in our growth.
In December 2015 we made our largest ever acquisition – our 31st since the company
commenced trading in 1998. The £127.5m purchase of Sinclair Pharma’s Healthcare
Products Business will double the size of our business, bringing us 27 products
generating annual sales of £39.4m in the 12 months to 31 December 2015.

These products, focused on dermatology and wound care, neatly complement our
existing portfolio. The combined portfolio supports our strategy with a well balanced
blend of stable, established products and growth brands, and enhances the balance
between prescription and over-the-counter products.

The big change comes in our international reach and scale. Previously, some 80% of
our sales came from the UK. Now, the split is broadly 50% UK, 25% Western Europe
excluding UK, and 25% Rest of the World. Our strategy to build our presence in the top
five EU markets has gained real momentum in France, Italy, Germany and Spain. And
we’ve gained an extensive network of distributors serving fast-growing markets in SE
Asia and footholds in the US and Latin America.

This expanded international footprint provides a strong platform for broadening sales of
our key growth brands, particularly Hydromol and MacuShield. And we’re now in a
much stronger position to bid for attractive product acquisitions and in-licensing
outside the UK.

Our increased scale will allow us to improve systems and gain operational efficiencies.
The combined strengths of our product portfolios – together with the excellent strategic
fit – will enable Alliance to build a truly international business.

New strength in Europe
Last year’s sales* figures for the acquired Sinclair products, top five markets:

France

UK

Italy

Germany

Algeria

£8.3m

£5.9m

£2.7m

£2.2m

£2.1m

Atopiclair

Flammacerium

Next five largest markets: Spain, China, Brazil, Belgium, Indonesia

Aloclair

Key growth brands
The acquisition brings us four key growth brands:

Kelo-cote (£7.7m*) – a patented gel for management of 
abnormal scars.

Wound
management

The Flamma range (£6.9m*) – unique sterile treatments for 
severe burns and wounds prone to infection. Includes
Flammacerium, designated as an orphan drug in the US, 
which we also plan to launch in the UK.

Aloclair (£4.2m*) – fast pain relief and healing for mouth 
ulcers, with a new ‘ultra’ version in development.

Skin care

Atopiclair (£1.7m*) – steroid-free treatment for dermatitis,
complementing the Hydromol range.

*Sales being the 12 months to 31 December 2015.

Alliance Pharma plc | Annual Report 2015 05

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06 Alliance Pharma plc | Annual Report 2015        

Growth through International Expansion

Internationalisation
accelerated in 2015
Following the Sinclair acquisition,
we now have a substantially larger
international footprint. Previously,
we made approximately 80% of our
sales in the UK. Now, the split is
broadly 50% UK, 25% Western
Europe excluding UK, and 25% Rest
of World.

We have gained new strength in
China, greater exposure to fast-
growing markets in SE Asia, and
footholds in the US and Latin
America. We have also boosted 
our position in Europe, gaining 
operating companies in France and
Italy and a sales presence in Spain,
meaning we now have significant
sales in each of the EU-5 (UK,
France, Germany, Spain & Italy).

pre-Sinclair

post-Sinclair

Non-UK
19%

Non-UK
49%

UK
81%

UK
51%

*Pro-forma sales for the 12 months to December 2015, including share of Joint Ventures.

1

UK – Chippenham

2

France – Paris

3

Germany – Düsseldorf

Our Group HQ will continue to be in
Chippenham where we have around 90
people working across supply chain,
finance, corporate development, sales and
marketing, regulatory, medical, quality,
IT and HR.

Whilst we are undertaking international
expansion, around 50% of Group sales are
in the UK and this remains an important
growth area in which we will continue to
review acquisition opportunities. The UK
domestic market commercial activities are
also managed from this office. 

We appointed Philippe Pasdelou in 2012 as
Country Manager in France, the same year
in which we made our first French product
acquisitions, Paludrine and Savarine. 

The Sinclair acquisition has brought a
significant platform for growth, bringing
both an office in Paris, with around 20
people, and £8m of sales (based on the 12
months to 31 December 2015). The Paris
office houses the French local country
organisation and also the Group’s
International business centre under 
Karim Husny.

Following the appointment of Lars Börger
as Country Manager of Germany, Austria
and Switzerland in 2012, Alliance made its
first German product acquisition, Irenat, 
in 2014. Following the Sinclair acquisition,
we have now established a small office in
Düsseldorf for commercial activities to
manage the newly expanded portfolio and
continue to look for new opportunities. 

1

2

3

4

Alliance Pharma plc | Annual Report 2015 07

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5

6

Head of International
Karim Husny was appointed Head of International at the
beginning of 2016 covering all our distributor-based business in
the expanded Group, which now accounts for some 25% of sales.
He brings extensive international experience in OTC and
consumer healthcare at European pharmaceutical firms
including Omega Pharma, Pfizer and Sanofi's Zentiva business.

Map key:

Direct Presence

Direct Presence being established

Distribution Partners

4

Italy – Milan

5

China – Shanghai

6

SE Asia – Singapore

With the Sinclair acquisition we now have
an office in Milan with around 12 people 
and sales in Italy of some £3m. The
principal activities in Milan are the
commercial management of the Italian
territory sales and also a part of the Group
quality function focusing on Medical
Devices.

Our activities in China grew considerably in
2015. From Sinopharm Nutraceuticals
Shanghai, we acquired five child nutrition
brands with annual sales of around £1.5m
but with significant turnaround potential. 

Additionally, one of the key growth brands
we acquired from Sinclair is Kelo-cote, a
scar treatment gel that sells well in China.

After some years of preparatory work we
now have a portfolio of products around
which we are developing our business in
China, and we look to build on this platform
over the next few years. 

We have recently appointed Roger Lim as
Regional Business Manager for SE Asia. 
We see this region providing significant
growth potential for the acquired products
from Sinclair as well as the historic Alliance
portfolio, and this appointment will keep us
close to the market.

 
 
 
 
08 Alliance Pharma plc | Annual Report 2015        

Corporate Development

Our core strategy remains the pursuit of organic
growth complemented by acquisitions, in-licensing
and modest development of line extensions.

We have a long track record of successful acquisitions, having completed 31
acquisitions and a number of in-licensing deals over the past 17 years.

Under our long-established ‘buy and build’ strategy we supplement organic growth 
with acquisitions that allow us to accelerate expansion and adjust the balance of our
portfolio. 

We will acquire established medicines with continuing clinical need, a history of stable
sales, limited competition and limited promotional support to add to our non-promoted
‘bedrock’ products. 

We will also acquire products and businesses with the potential for growth through
targeted promotional investment. In recent years we have been broadening the growth
element of our portfolio to include consumer healthcare products. Our developing
experience in this area enables us to identify products that offer substantial organic
growth potential in return for relatively modest promotional investment. The Sinclair
Healthcare Products acquisition has further increased our consumer focus and this
will be important moving forward. These consumer products also have a degree of
pricing flexibility and therefore help to balance margin risk across the portfolio.

We will work closely with existing and new partner companies to share and license
rights to assets that have growth opportunities.

We will concentrate our commercial growth activities behind the therapy areas of
Dermatology, Mother & Child and Ophthalmology, making full use of our expanded
geographic footprint.

We will leverage our new scale to attract wider international licensing opportunities,
such as pan-EU deals and deals with partners outside Europe.

We have access to considerable financial resources to fund future deals, both through
our investor base and our banking partners.

To enable us to deliver on our strategy, the group has a dedicated Corporate
Development team who actively seek acquisition and licensing opportunities. We have
considerable expertise in target selection, contract negotiation, due diligence and
efficient integration of acquired products and businesses into our organisation.

Dan Thomas, Chief Corporate
Development Officer

Irenat

Acquired January 2014, Germany

MacuShield

Acquired February 2015, Global exc. US

Sinclair Healthcare Products Business

Suprememil

Acquired December 2015

Joint venture January 2014, China

Lypsyl

Acquired December 2013, UK & ROI

Growth through Acquisitions

Strong track record of successful acquisitions.

£16m

£6m

£12m

£9m

Alliance Pharma plc | Annual Report 2015 09

£139m

£4m

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2010
1 DEAL

2011
3 DEALS

2012
2 DEALS

2013
2 DEALS

2014
2 DEALS

2015
4 DEALS

31 31 Deals

in 17 years.

90 Over 90

Products.

Building
global operation.

Acquisitions

In licensing

We are actively seeking opportunities to
acquire individual products, portfolios
of products or corporates that meet our
target criteria.

Within the 31 acquisitions, we acquired products from several of
the multi-national and mid-tier pharma companies, as well as
making a number of corporate acquisitions.

We welcome speculative approaches. We are open to acquisitions
in any therapy area or geography, although we are particularly
interested in products which complement any of our existing
therapy areas or which have sales in the ‘EU5’ territories (UK,
France, Germany, Spain & Italy) or in China.

Our evaluation processes are well developed and managed by a
dedicated team of professionals who engage with colleagues in
both the commercial and functional support areas (technical
operations, medical, regulatory, finance, legal, HR) as required in
order to facilitate a rapid and thorough assessment. As part of
this process, the team routinely manage integration planning and
any transitional arrangements, so as to make the subsequent
incorporation of the new assets as smooth as possible.

We seek to in-license the rights to new
product opportunities in therapy areas
which are complementary to our
existing promoted business interests in
Dermatology, Mother & Child, and
Ophthalmology. We are equally happy to
look at products in other therapy areas
too, which otherwise fit our criteria.

Typically we would look to take-on products for which all clinical
trial work has been completed that are either in the process of
registration, or which are already registered and ready to
commercialise.

We have good experience in bringing new products to market,
leveraging the relationships we have fostered with healthcare
professionals in our existing promoted therapy areas.

We seek international licensing opportunities, such as pan-
EU deals.

Our assessment processes for in-licensing opportunities mirror
those for acquisitions, being led by our Corporate Development
team, supported by expertise from elsewhere in the business, as
needed. We aim to complete a thorough and timely assessment
of opportunities and will work with prospective licensing 
partners to agree a balanced share of the risks and rewards
inherent in bringing a new product to market and developing its
market position.

 
10 Alliance Pharma plc | Annual Report 2015          

Promoted Brands

Our promoted portfolio is focused on three key 
areas: Dermatology, Mother and Child, and
Ophthalmology.

In addition to Sinclair, we made three important additions in 2015 to these areas, from
which we expect to drive significant growth in the next few years: 

l    MacuShield, a treatment for age-related macular degeneration, gives us a fast-

growing product with major potential for internationalisation. 

l    Diclectin, which we have in-licensed for the UK market, is on track to be the UK’s

only licensed product for nausea and vomiting of pregnancy. 

l    Five child nutrition brands in China from Sinopharm Nutraceuticals Shanghai

(‘SNS’). These add to our Mother and Child business in China and have significant
turnaround potential.

Our increased scale and international reach now also provides an enhanced platform
for further development. This creates new marketing opportunities for our existing
products and also the acquired Healthcare Products from Sinclair.

Ophthalmology

MacuShield 

Acquired in February 2015, MacuShield is the UK’s
most recommended eye care supplement by opticians. 
MacuShield is a unique food supplement containing the three macular pigments Lutein,
Zeaxanthin and Meso-Zeaxanthin, and is designed to be taken by sufferers of dry age-
related macular degeneration (‘AMD’) and other eye conditions. The product is
supported by numerous peer-reviewed published studies.

Sales of MacuShield were £3.5m in the 11 months to 31 December 2015, representing
growth on a twelve month basis of 13% on the previous year. Of the £3.5m of sales,
some 90% of this was in the UK & ROI. This demonstrates the potential for international
expansion through our expanded global distribution partner network.

International potential

International
10%

ROI
18%

UK
72%

The UK’s most 
recommended eye care
supplement

 
 
 
Alliance Pharma plc | Annual Report 2015 11

Kelo-cote

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Dermatology

Kelo-cote

Kelo-cote, acquired as part of the Sinclair 
Healthcare Products Business, is now Alliance’s
largest brand with sales in the 12 months to 31
December 2015 of £8m. 
Kelo-cote is a patented, non-invasive, clinically proven solution to prevent and treat
excessive scarring. It forms a self-drying, transparent silicone layer which creates a
flexible and breathable barrier, enabling the affected area to heal under the best
conditions to reduce redness. This will flatten and diminish the appearance of raised or
coloured scars as old as four years, along with relieving itching and discomfort.

With a presence in more than 60 countries and over one million patients treated
worldwide, Kelo-cote is a prized brand that we see as having further potential for 
international growth.

Hydromol

Hydromol

The Hydromol complete emollient therapy range 
is used to control dry skin conditions and improve
skin hydration.
Dermatological conditions are among the most common diseases encountered by
healthcare professionals. Atopic eczema accounts for 30% of all dermatological
consultations in general practice, and the prevalence is increasing. Estimates vary due
to the different populations examined, but figures suggest a prevalence of around 
15-20% in children and 2-10% in adults.

Hydromol has achieved good growth over a number of years, and in 2015 continued to
do so; sales grew by 10% to £6.6m.

Our increased scale and international reach provide an enhanced platform for further
development, creating new marketing opportunities for Hydromol.

 
12 Alliance Pharma plc | Annual Report 2015          

Promoted Brands continued

Mother and Child

Diclectin

Alliance in-licensed Diclectin from Duchesnay Inc. 
in January 2015.
This combination of a widely-used antihistamine with vitamin B6 has a well-established
safety and efficacy profile and has been used for over 30 years in Canada to treat
nausea and vomiting of pregnancy. We submitted Diclectin for UK registration in the
second quarter of 2015, and we estimate being able to launch in 2017. 

In the United States, it was licensed by the FDA in 2013 under the name Diclegis with a
Category A safety rating for drugs used during pregnancy. Since then, sales have
reached $160m in under three years, which augurs well for its prospects in the UK.
Pending UK approval, we are undertaking market access work with NHS budget
holders to facilitate uptake at launch.

We believe Diclectin represents an exciting growth opportunity for Alliance over the 
next 5 years. 

Ashton & Parsons

Ashton & Parsons

Ashton & Parsons Infants' Powders are a gentle,
natural remedy for the pain and symptoms 
associated with teething.
Originally developed in 1867 by Ashton & Parsons London, The City Homeopathic
Pharmacies, these Infants' Powders have been used to soothe the symptoms of
teething pain for nearly 150 years. Made from tincture of Matricaria, which is extracted
from German Chamomile flowers, Ashton & Parsons is proud to be Britain’s No.1
Teething Remedy in Pharmacies. 

Sales in 2015 were £1.5m, and in 2016 we will be building distribution listings to 
ensure wide availability.

Development of the Organisation

Alliance Pharma plc | Annual Report 2015 13

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Janice Timberlake, Chief Human
Resources Officer

Stephen Kidner, Chief Scientific and
Operations Officer

Organisation & People

Scientific Affairs & Operations

In February 2016 we brought together
our Medical & Regulatory Affairs and
Operations departments to create one
Scientific Affairs and Operations team.
By integrating all the functions needed
to supply cost-effective and compliant
product we aim to streamline our
processes and by doing so expect to
realise greater operating efficiency 
and effectiveness. 

We now source products from 50 manufacturing partners
concentrated within Europe and by doing so have retained our
agile, asset light and low risk manufacturing model. Active
tendering and supplier relationship management ensures the
right spread of partners and that mutual value is realised.

Reflecting the increased scale and scope of our global supply
chain operations we have strengthened our logistics capabilities.
We have invested in our quality management team whilst
leveraging strengths acquired in the quality management of
medical devices in Milan.

Whilst our current focus is firmly on integrating our new
enlarged business we have begun our search for a new ERP
system which we anticipate will be operational late in 2017.
Having the entire Alliance group on a single ERP platform will
enable us to run our global operations far more efficiently.

We continue to be an exciting and
dynamic organisation, growing through
acquisition to create an increasingly
international footprint. The recent
acquisition has brought 41 new people
into the business in France, Italy and in
the UK, which together with a number 
of new appointments in the UK, Spain,
Germany, Singapore & China will bring
our people base to around 150 globally.

Our capable people are at the heart of our business; a diverse
team of dedicated, enthusiastic and experienced professionals
who are committed to providing much needed medicines
around the world. As our international footprint increases, we
are becoming more multi-cultural. We recognise and celebrate
this diversity, learning from one another, and sharing cultural
perspectives. This adds strength and quality to our thinking and
delivery, so creating a healthy progressive culture. 

This environment also enables us to attract people from top 
blue chip pharmaceutical and non-pharmaceutical companies.
We have recruited this year across several disciplines, from
supply chain, finance, sales and marketing to more specialist
pharmaceutical disciplines of development, regulatory, medical
and quality. These people bring with them expertise on many
brands, therapy areas and wide-ranging professional 
experiences and best practice.

The growth over the past year has also created exciting
opportunities for our people to develop their careers with us.
We encourage our people to stretch themselves personally by
taking on fresh challenges and projects.

Developing our skills and capability is important to Alliance 
and over the past year we have continued to support part-time
study, professional exams, short skills courses, continuous
professional development and have several internal
development programmes, including personal impact, 
change management and essential management skills
programmes.

 
14 Alliance Pharma plc | Annual Report 2015          

Strategic Report

2015 was a transformational year for Alliance. Following the acquisition of the
Healthcare Products Business from Sinclair IS Pharma plc, we will double the scale 
of our business – in terms of sales, profits and people. We have extended our reach
from around 40 countries to over 100 and extended our portfolio to some 90
products. Importantly this greatly strengthens our presence in Europe enhancing our
ability to compete for future pan-European licensing and acquisition opportunities. 
It also brings extra business into our China operation and in South East Asia, where
we will establish a base in Singapore. Alliance is now a truly international business.

The acquisition from Sinclair for £132.2m (including inventory),
announced on 17 December 2015, was our largest acquisition to
date, bringing us 27 products which generated annual revenues to
31 December 2015 of £39.4m. 

In addition, we made two other important additions in the first
quarter of 2015, from which we expect to drive significant growth
in the next few years. MacuShield, a treatment for age-related
macular degeneration, gives us a fast-growing product with major
potential for internationalisation. And Diclectin, which we have in-
licensed for the UK market, is on track to be the UK’s only
licensed product for nausea and vomiting of pregnancy. We also
acquired five child nutrition brands in China from Sinopharm
Nutraceuticals Shanghai (‘SNS’) in September 2015. These add to
our Mother and Child business in China and have significant
turnaround potential.

These additions represent exciting prospects for our performance
in 2016 and beyond and should not overshadow the good progress
made in our underlying business over the past year. Our sales
growth of over 11% in 2015 was due to a strong performance of
our existing portfolio and the impact of the MacuShield. 

Trading performance
Sales rose over 11% to £48.3m, including £0.8m contributed by the
acquired Sinclair business in December. Excluding Sinclair, the
sales increase was almost 9%.

The principal growth driver continued to be the Hydromol
dermatology range, up 10% to £6.6m. Anbesol, one of our
consumer health products, has continued to benefit from a strong
following on social media and sales grew 20% to £1.5m. Gelclair,
our treatment for oral mucositis, rose 5% to £1.4m. And Forceval
capsules recovered strongly from earlier stock-outs, with sales up
by £0.6m to £2.1m.

MacuShield, acquired in February 2015, outperformed our
expectations, contributing £3.5m of sales.

Partially offsetting these gains was the loss of revenue from nine
products that we handed back to Novartis in 2014. In the 2014
financial year, they contributed sales of £1.6m although the
margins on the products were relatively small. Nu-Seals
continued to suffer sales erosion by generic competitors in
Ireland, and sales fell by a further £0.6m to £1.9m; we are still
awaiting a decision from the regulator on whether to allow generic
substitution by pharmacists. Quinoderm Cream remains off the
market, as the sole manufacturer of the active ingredient has
ended production. We are in the process of developing alternative
supplies, and look forward to recommencing sales in early 2017.

We have been preparing to put marketing support behind two key
brands in 2016. We trialled TV advertising for Ashton & Parsons
Infants’ Powders in 2015, and before committing to a full campaign
we are building distribution listings to ensure wide availability;
meanwhile, sales levelled-off in 2015 at £1.5m after strong growth
in 2014. Lypsyl sales were also flat at £1.1m while we worked on
redesigning the product for relaunch in 2016.

Our substantial bedrock portfolio of unpromoted products
performed well, with overall sales stable as expected.

In Europe, our French and German businesses maintained stable
sales volumes – although the value was affected by the relative
strength of sterling against the euro during the year.

In China, we currently have a 20% stake in Synthasia International.
In 2015 we helped to resolve some supply issues with its Swiss
manufacturer of infant milk formula products and our 20% share
of the sales grew 29% to £0.4m. Forceval, which we sell in China
through a distributor, suffered from stockholding fluctuations:
sales fell from £1.6m in 2014 to £0.9m, but are now recovering.
Our child nutrition brands, acquired in September 2015,
contributed £0.2m sales.

Financial performance
Pre-tax profits were up 49% to £15.2m (2014: £10.2m). However,
this result benefited from the balance of some significant one-off
items. Excluding these, the underlying trading profit was up 6% to
£11.4m (2014: £10.8m).

These major exceptional items included £6.3m (net) compensation
received for the suspension of ImmuCyst production by Sanofi,
partially offset by Sinclair acquisition costs of £1.8m together with
a fair value adjustment to the deferred consideration for the
MacuShield acquisition of £0.5m, partly triggered by better-than-
forecast sales growth. 

Gross profit was up 15% to £28.7m (2014: £25.0m), giving a gross
margin for the year of 59.4%. This increase on the 57.5% achieved
in 2014 was primarily due to a more favourable mix following
handback of the nine Novartis products. We expect to maintain
gross margins at 55-60%.

The increase in gross profit was partially absorbed by higher
operating costs of £16.3m, excluding non-underlying items, up
from £13.3m in 2014. This resulted from increased marketing
investment in key brands, particularly MacuShield following
acquisition, pre-launch preparation for Diclectin and a
strengthening of the supply chain function leading to a modest
increase in staff numbers and costs.

Alliance Pharma plc | Annual Report 2015 15

MacuShield, acquired 
in February 2015,
outperformed our
expectations,
contributing £3.5m 
of sales.

Gross profit was up 
15% to £28.7m (2014:
£25.0m), giving a gross
margin for the year of
59.4%. 

In recent years we have
been broadening the
growth element of our
portfolio to include
consumer healthcare
products. 

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Operating profit – excluding non-underlying items – was £12.5m
(2014: £11.8m). This represented 25.8% of sales (2014: 27.1%), the
slight decrease being driven by the above mentioned increased
investment.

The underlying business remains strongly cash generative.
However, in 2015 free cash flow reduced to £6.3m (2014: £10.3m).
The principal factors were one-off events: planned stock building
to pre-empt supply disruptions, and the inventory costs resulting
from the Sinclair products acquisition.

The Sinclair acquisition was financed by increases in both share
capital and bank debt. The issue of some 204m shares raised a net
£80.8m. For the balance, we negotiated an increase in bank
facilities from £55m to £100m, from which we drew £75m for
acquisition funding and repayment of existing facilities. This
resulted in net debt at the year-end of £71.5m (2014: £21.1m),
which we expect to reduce progressively with cash generated by
the enlarged business.

At the year-end, the bank debt/EBITDA ratio was 2.8 times on a
pro forma basis including historic EBITDA for the Sinclair
business. This compares with 1.6 times at the end of 2014.

At the year-end, our unused bank facility stood at £25.0m (2014:
£23.8m) plus a £5m overdraft facility.

Earnings per share and dividend
Reported earnings per share (EPS) was 4.65p (2014: 3.17p).
Adjusted for non-underlying items, the diluted EPS figure was 3.61p,
8% above 2014.

The 2015 EPS figure is based on a time-weighted average number
of shares for the year of 279m, reflecting the increased number of
shares in issue at the year-end of 468m, compared with 264m in 2014.

Given the year’s strong performance, and consistent with our
progressive dividend policy, we are recommending a final payment
of 0.734p per ordinary share to give a total for the year of 1.1p. This
represents an increase of 10% on 2014. The final dividend will be
paid on 13 July 2016 to shareholders on the register on 17 June
2016. Although the new shares for the Sinclair acquisition were
issued in December 2015, this had a minimal impact on EPS
dilution, and the level of dividend cover in 2015 remained ample at
over three times. The total dividend payment for 2015 will be £5.1m
including the £1.7m interim payment.

Strategy
Our business model is based on a diversified and growing portfolio
of products and brands, in which no single brand currently
accounts for more than about 9% of total sales. This portfolio

balances two elements. We have a segment of brands with growth
potential in which we invest and we have a bedrock of brands that
are well established in their market niches and will maintain their
sales for many years with little or no promotion. By balancing the
two, we can invest in targeted marketing to grow sales while
maintaining good cash generation and profitability.

Our promoted portfolio is focused on three key areas: Dermatology
where our main products are Kelo-cote, Hydromol and
Flammazine/Flammacerium; Mother and Child where our key
products are Oxyplastine, Ashton & Parsons, Diclectin (pre-launch)
and Suprememil in China; and Ophthalmology with MacuShield
where a significant internationalisation opportunity exists. 

Under our long-established ‘buy and build’ strategy we
supplement organic growth with acquisitions that allow us to
accelerate expansion and adjust the balance of our portfolio. 

In recent years we have been broadening the growth element of our
portfolio to include consumer healthcare products. Our growing
experience in this area enables us to identify products that offer
substantial organic growth potential in return for relatively modest
promotional investment. These consumer products also have a
degree of pricing flexibility and therefore help to balance margin risk
across the portfolio. The February 2015 acquisition of MacuShield
has further boosted our offer to both healthcare professionals and
retailers. We are promoting it to ophthalmology clinicians, who
recommend it to suitable patients to purchase over-the-counter
(‘OTC’), where we also have promotional capabilities.

We further expanded our prescription healthcare portfolio in 2015
by in-licensing Diclectin. This combination of a widely-used
antihistamine with vitamin B6 has a well-established safety and
efficacy profile and has been used for over 30 years in Canada to
treat nausea and vomiting of pregnancy. We submitted Diclectin for
UK registration in the second quarter of 2015, and we estimate
being able to launch in 2017. In the United States, it was licensed
by the FDA in 2013 under the name Diclegis with a Category A
safety rating for drugs used during pregnancy. Since then, sales
have reached $160m in under three years, which augurs well for
its prospects in the UK. Pending UK approval, we are undertaking
market access work with NHS budget holders to facilitate uptake
at launch.

On the acquisition side, the Sinclair Healthcare Products Business
fits very well with our strategy. We have gained 27 products
including four key growth brands. Of these, three (Kelo-cote,
Flammazine/ Flammacerium and Atopiclair) are in skincare and
wound management; the other (Aloclair) is an OTC consumer
treatment for mouth ulcers.

 
16 Alliance Pharma plc | Annual Report 2015          

Strategic Report continued

Since completion of the acquisition in mid-December 2015, sales of
Kelo-stretch, which had been identified as a key growth brand, have
been lower than we had anticipated despite extensive promotional
activities by A. Menarini Asia-Pacific Pte. Ltd., our key partner in
South East Asia. Despite this, other Sinclair brands they distribute
for us are performing well. The relationship with Menarini remains
strong and other opportunities are being positively explored. The
2016 impact of the Kelo-stretch shortfall is estimated at a possible
reduction of £1.2m at the operating profit level. Notwithstanding
this, trading to date for the Sinclair Healthcare Products in
aggregate has remained in line with management’s expectations.

In the expanded product portfolio, the balance between promoted
and non-promoted ‘bedrock’ products remains roughly equal thus
balancing cash flow stability and promotion driven growth. The
balance between OTC and prescription products has shifted slightly
in favour of OTC – but the impact on marketing costs will be limited
because a large proportion of Sinclair product sales are made
through distributors, who bear the cost of advertising.

We now have a substantially larger international footprint.
Previously, we made approximately 80% of our sales in the UK.
Now, the split is broadly 50% UK, 25% Western Europe excluding
UK, and 25% Rest of World. We have gained new strength in China,
greater exposure to fast-growing markets in SE Asia, and footholds
in the US and Latin America. We have also boosted our position in
Europe, gaining operating companies in France and Italy and a
sales presence in Spain.

Our core strategy remains unchanged, with organic growth
augmented by acquisitions, in-licensing and modest development
of line extensions. Our increased scale and international reach
provide an enhanced platform for further development. They create
new marketing opportunities for our existing products, particularly
Hydromol and MacuShield, and strengthen our hand in seeking
acquisition and in-licensing opportunities outside the UK. We
intend to maintain a balance between non-promoted bedrock
products and our three promoted growth areas: Dermatology,
Mother and Child, and Ophthalmology.

Integration of the Sinclair products and teams is on track and will
continue through 2016. Our Chippenham office remains the Group
and UK headquarters, while our international distributor
management is run from our international business centre in Paris
where we have staff of around 20 people. We are establishing a
small office in Singapore to manage operations in SE Asia.

Our activities in China grew considerably in 2015. From Sinopharm
Nutraceuticals Shanghai, we acquired five child nutrition brands
with annual sales of around £1.5m but with significant turnaround
potential. We now own these brands outright, and are marketing
them through our part-owned Synthasia business. Additionally, one
of the key growth brands we acquired from Sinclair is Kelo-cote, a
scar treatment gel that sells particularly well in China. 

After some years of preparatory work we now have a portfolio of
products around which we are developing our business in China,
and we look to build on this platform over the next few years. To
facilitate our trading in China we have established a ‘wholly owned
foreign enterprise’ in the Shanghai Free Trade Zone.

We resumed sales of our bladder cancer treatment, ImmuCyst, in
February 2016. This had been one of our lead products until our

supplier, Sanofi Pasteur, suspended production in mid-2012 for
which we received compensation of £6.3m, net of costs, in 2015.
Despite ImmuCyst’s absence for three and a half years, the market
remained underserved until recently, as the only competitor
treatment was in short supply. It is difficult to estimate our likely
market share going forward, as our supplies from Sanofi will be
limited and we believe the competitor product is now available in
greater quantities.

Team
In September we welcomed Andrew Franklin to the Board as Chief
Financial Officer. Andrew was Finance Director and Company
Secretary of Genzyme Therapeutics Ltd from 2010 to 2012 and had
previously held senior financial management positions with Wyeth
for over 12 years. He joined us from Panasonic Europe, where he
was General Manager, European Tax and Accounting.

Non-executive Director Nigel Clifford joined the Board in 
January 2015.

Consequent upon the planned departure in 2016 of Tony Booley, our
long-standing Executive Director – International, we have brought
together the Group’s commercial leadership under Peter
Butterfield as Chief Commercial Officer. Reporting to Peter, Karim
Husny has joined Alliance as Paris-based Head of International
covering all our distributor-based business, which now accounts for
some 25% of sales. He brings extensive international experience in
OTC and consumer healthcare at European pharmaceutical firms
including Omega Pharma, Pfizer and Sanofi's Zentiva business.

About 40 key staff have joined us from Sinclair and we are recruiting
around 20 more to support the new products and operations.

Charity
We continue to donate products regularly to International Health
Partners, which distributes medicines to doctors in the world’s
neediest areas. We also support employee fundraising for local
causes including Wiltshire Air Ambulance and Bristol charity
PROPS, which provides support for young people with learning
difficulties and disabilities and their families.

Outlook
In 2016 and beyond, we look forward to building on the greatly
enlarged platform established during 2015. We acknowledge the
effort required this year to integrate two organisations with
different working methods, data and IT systems; but the process is
already well underway and progressing successfully. Although
most of the one-off costs of the Sinclair acquisition were met in
2015, we expect the bulk of the integration costs to be borne in
2016. We also intend to take the opportunity to invest in a
significant new enterprise resource planning (‘ERP’) system over
the next 18 months.

We are very pleased with the Sinclair products acquisition and,
notwithstanding the Kelo-stretch shortfall, we expect the enlarged
Group to perform in line with expectations for the full year. 

In the meantime we will maintain our long-term ‘buy and build’
strategy for business growth. Our increased capitalisation and
greatly strengthened international position will significantly
enhance our ability to grow both organically – by our access to
much larger markets – and through further acquisitions.

Alliance Pharma plc | Annual Report 2015 17

Our increased scale and
international reach
provide an enhanced
platform for further
development. 

Our activities in China
grew considerably in
2015.

About 40 key staff
have joined us from
Sinclair.

Principal risks and uncertainties
The Group’s principal risks and uncertainties are outlined below.

Integration of the Healthcare Products Business acquired 
from Sinclair

The integration of the Sinclair acquisition, completed on 17
December 2015, is a key area of focus in 2016. The acquired
business brings offices in Paris and Milan, and also operates on
different IT systems to the existing Group. As such, rationalising the
Group onto a common ERP system will be a project extending
through to 2017. In addition, there is an increased risk from the
number of new contract manufacturing organisations (‘CMOs’) and
distributors and we will build relationships in the first half of 2016
with them in order to maintain supply and develop sales. See note
35 for more detail on this acquisition. 

A dedicated Project Manager has been assigned to the integration
to ensure key transition milestones are achieved by the business to
the required timetable. The Project Manager is supported by a
cross-functional team, with regular communication across the
business providing the necessary skills and resource to enable a
successful transition. 

Financial risk management 

The Group regularly monitors its cash flow and covenant forecast,
allowing for mitigating actions to be taken to remain within contracted
covenants and plan ahead to make regular debt payments. 

The Group monitors credit risk closely and considers that its
current policies of credit checks meets its objectives of managing
exposure to credit risk. The Group’s other financial risk
management policies and objectives are detailed in note 21 of the
financial statements.

The Sinclair acquisition primarily increases the exposure that
Alliance has to fluctuations in the US Dollar and the Euro. To
mitigate the impact of Dollar and Euro receipts devaluing, a
proportion of the loans to fund the acquisition were drawn down in
US Dollar and Euro denominations (see note 21). We will continue
to monitor the Group’s exposure and use financial instruments,
such as forward contracts, to manage this risk as required. 

Sales volumes being affected by supply chain constraints

Issues within the supply chain can interrupt supply leading to
insufficient stock being available to meet demand, particularly as
all manufacturing is outsourced and is therefore outside our direct
control. Over the last few years Alliance has taken a number of
measures to strengthen its supply chain. These include where
possible strengthening the supply chain team within the business,
dual sourcing of some key products and of some key ingredients,
holding larger buffer stocks of selected products and improved
communication with suppliers.

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Sales volumes being affected by a change in demand

Changes in demand for pharmaceutical products could be caused by
a number of factors, such as changes in the competitive environment.
Key criteria when Alliance selects products to add to its portfolio are
that the products are in niche areas and that the products have many
years of steady sales history prior to acquisition. 

Sales pricing being reduced by regulatory action

Pricing pressure is being seen across Europe as countries look to
reduce their national debt. Our largest exposure is in the UK where
around 18% of the Group’s revenues were from products covered by
the Pharmaceutical Price Regulation Scheme (‘PPRS’) in 2015, which
is the UK Government’s tool for controlling pricing for the NHS.
Alliance is a member of the ABPI and other industry bodies which 
are consulted by the Government on changes to the PPRS. The 
latest scheme commenced in January 2014 and runs for five years.
Most of the other UK revenue is from products that are medical
devices, sold over the counter or are generic. The regulatory regime
for medical devices allows for inflationary price increases each year
and over the counter and generic products are freely priced.
Following the acquisition of the Healthcare Products Business from
Sinclair, and the resulting internationalisation, the concentration 
risk for pricing reductions in the UK is now significantly reduced. 

Cost price inflation affecting gross margins

Increases in the cost of goods could erode gross margins. In a
number of cases Alliance has arrangements with suppliers which
either fix prices or limit price increases over the next few years. 
At the expiry of such arrangements, prices are tested against
prevailing rates in the market. Alliance also looks for improvements
in production techniques to reduce the cost of manufacturing.

System failure or cyber security breach

The Group has a range of measures in place to monitor and 
mitigate this risk: networks and systems are protected by anti-virus
software, firewalls and network segmentation that are regularly
updated; regular introduction of more up to date software also
provides additional in-built security; and incident management,
business continuity management and IT disaster recovery plans are
in place for critical business processes to mitigate the effects of the
business being unable to operate in the event of a major incident.

On behalf of the Board

Sarah Robinson
Company Secretary
6 April 2016

 
18 Alliance Pharma plc | Annual Report 2015          

Board of Directors

Directors who held office at the date of this report are set out below. All were
Directors throughout 2015 with the exception of Andrew Franklin, who was
appointed 28 September 2015, and Nigel Clifford, who was appointed with effect
from 26 January 2015.

Andrew Smith
Non-Executive Director, Chairman235
Andrew joined the Board of Alliance in 2006. He has held various senior positions 
in the pharmaceutical industry in the UK and USA having been Managing Director
and Senior Vice-President of SmithKline Beecham Pharmaceuticals (now
GlaxoSmithKline), chief executive of Cerebrus plc until its sale, and President of
International Medical Marketing Services with Parexel International. Andrew is a
founder of Navitas BioPharma Consulting. He graduated in Natural Sciences from
the University of Cambridge.

John Dawson
Executive Director, Chief Executive Officer4
John founded Alliance in 1996. He gained multi-disciplinary experience in the
pharmaceutical industry over thirty years. John held various senior roles at Sandoz
(now Novartis AG) as Director of Finance and Administration and Deputy Managing
Director. John has a BSc (Pharmacy) and an MSc (Finance) from the London
Business School.

Andrew Franklin
Executive Director, Chief Financial Officer 
Andrew joined Alliance in September 2015 from Panasonic Europe Ltd, where he
was General Manager – European Tax and Accounting. From 2010 to 2012 Andrew
was Finance Director and Company Secretary of Genzyme Therapeutics Ltd, the UK
& Ireland subsidiary of Genzyme Corporation, the biotechnology company acquired
by Sanofi. Prior to that, he gained 12 years pharmaceutical experience with Wyeth in
a variety of senior financial positions.

Tony Booley
Executive Director
Tony joined Alliance in 1998. He has had around 30 years’ experience in the
pharmaceutical and healthcare industries, with positions at Leo Pharma, Glaxo
Wellcome (now GlaxoSmithKline) and Getinge Industrier AB. His senior
management experience includes positions in the UK and overseas. Tony graduated
in Physiology, has an MBA from the University of Warwick and is a Chartered
Marketer. On 23 November 2015 it was announced that Tony had informed the Board
of his intention to leave the Company in order to pursue other business interests.
Tony will remain in his role until the handover of his duties is completed, which is
expected to be by 30 June 2016.

Alliance Pharma plc | Annual Report 2015 19

Peter Butterfield
Executive Director, Chief Commercial Officer
Peter joined the Board of Alliance in February 2010 following the acquisition of
Cambridge Laboratories, where he spent five years, latterly as UK Commercial
Director. He is a Board Member of the Association of the British Pharmaceutical
Industry (‘ABPI’) and is chairman of the ABPI Small Companies Forum. Prior to
joining Cambridge Laboratories, Peter spent six years at GlaxoSmithKline. 
He holds an honours degree in Pharmacology from the University of Edinburgh.

Thomas Casdagli
Non-Executive Director46
Thomas joined the Board of Alliance as a non-executive director on 3 March 2009.
He is a partner at MVM Life Science Partners LLP, a life science venture capital
fund. He has been an active investor in life sciences since joining MVM in 2002.
Before joining MVM, Thomas worked at PricewaterhouseCoopers LLP where he
qualified as a Chartered Accountant. Thomas graduated in Molecular and Cellular
Biochemistry from the University of Oxford in 1998.

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Nigel Clifford
Non-Executive Director246 (appointed to Committees on 24 February 2015)
Nigel joined the Board of Alliance as a non-executive director on 26 January 2015.
He is currently Chief Executive Officer of Ordnance Survey and formerly a non-
executive director of Anite plc. He has previously held senior positions at Proceserve
Holdings Limited as Chief Executive, Micro Focus International plc, Nokia, Symbian
Software Ltd, Tertio Telecoms Limited, Cable and Wireless plc, Glasgow Royal
Infirmary NHS Trust and BT plc. Nigel graduated in Geography from the University
of Cambridge and has an MBA from Strathclyde University.

David Cook
Non-Executive Director146
David joined the Board of Alliance as a non-executive director on 1 April 2014. He is
currently Chief Financial Officer and Chief Business Officer of Biotie Therapies Corp,
a drug development company quoted in Helsinki on the NASDAQ OMX market and in
New York on NASDAQ. He has previously held senior financial positions with Jazz
Pharmaceuticals International, EUSA Pharma Inc and Zeneus Pharma. David
qualified as a Chartered Accountant with PricewaterhouseCoopers after graduating
in Chemistry at the University of Oxford.

1 Chairman Audit Committee                     2 Audit Committee member                         3 Chairman Nomination Committee 
4 Nomination Committee member            5 Chairman Remuneration Committee       6 Remuneration Committee member

 
 
 
20 Alliance Pharma plc | Annual Report 2015        

Corporate Governance

Introduction

Alliance Pharma plc is an AIM listed company and the Board is committed 
to achieving good standards of corporate governance, integrity and 
business ethics.

Responsibilities of the Board
The Board is responsible to the shareholders for:

l    Setting the Group’s strategy

l    Maintaining the policy and decision-making process around

which the strategy is implemented

l    Ensuring that necessary financial and human resources are in

place to meet strategic aims

l    Monitoring performance against key financial and non-

financial indicators

l    Providing leadership whilst maintaining the controls for

managing risk

l    Overseeing the system of risk management

l    Setting values and standards in corporate governance

matters.

There is a list of matters reserved for the Board which may be
updated by the Board and approved by the Board only. 

The Chairman is responsible for leading the Board, facilitating the
effective contribution of all members and ensuring that it
operates effectively in the interests of the shareholders. The Chief
Executive Officer is responsible for the leadership of the business
and implementation of the strategy. The Company Secretary is
responsible, on behalf of the Chairman, for ensuring that all
Board and Committee meetings are conducted properly, that the
Directors receive the appropriate information prior to the
meeting, for ensuring that governance requirements are
considered and implemented and for accurately recording each
meeting. The Directors may have access to independent
professional advice, where needed, at the Group’s expense.

Board Evaluation and Governance Review
In 2014 the Board conducted a Board Evaluation and a Review of
Corporate Governance. The Evaluation and Review are conducted
biennially. The Board Evaluation, reviews the effectiveness of the
Board in determining the corporate strategy, governance and
controls, and Board development. The Evaluation results are used
to develop the effectiveness of the Board when progressing the
corporate strategy and oversight of the control structure within 
the organisation. 

We do not comply with the UK Corporate Governance Code.
However, we have reported on our Corporate Governance
arrangements by drawing upon best practice available, including
those aspects of the UK Corporate Governance Code we consider
to be relevant to the Company.

The review noted that the appointment of David Cook in April 2014
and the appointment of Nigel Clifford in January 2015 would build
on the independence of the Board. The Board did not consider
that the appointment of a senior independent director was
necessary but will consider this at each review. The UK
Governance Code requires the Board to consider their policy on

gender diversity in the boardroom, to report against it annually
and to consider diversity as a factor when evaluating the
effectiveness of the Board. Therefore the Company searches for,
recruits and appoints the best available person on the basis of
aptitude and ability, regardless of sex, marital or civil
partnership status, race, colour, nationality, ethnic or national
origins, pregnancy, disability, age, sexual orientation, religion,
belief or gender reassignment.

Relations with Shareholders
At each meeting, the Board is updated on the meetings and
communications with the shareholders and an analysis of the
shareholder base is presented. Research notes by brokers are
circulated to all Board members. Throughout the year the Chief
Executive Officer and Chief Financial Officer meet with the
large, institutional shareholders who hold the majority of the
shares. Regular feedback is given to the Board following
meetings with the shareholders from the financial PR advisors
and from the shareholders via the brokers.

The Group recognises that whilst the majority of the shares are
held by large institutions, attention should be paid to the private
shareholders and the Investors section of the Group’s website is
regularly updated and amended with the aim to provide good
information to all shareholders, particularly private investors.
The website provides a facility to receive email alert notifications
of Group news and stock exchange announcements. In addition
the Chief Executive Officer and Chief Financial Officer regularly
present at conferences attended by many potential and current
private shareholders and meet with Private Client Fund
Managers representing the interests of private investors
following which feedback is given to the Group. 

At the Annual General Meeting the Chairman issues a
statement on current trading. Directors are available following
the meeting to answer questions and for informal discussions.
The results of the proxy votes are announced at the meeting,
including the abstentions and these are published on the
website following the meeting.

Modern Slavery Act 
Relevant commercial organisations are required to prepare and
publish a slavery and human trafficking statement each
financial year. The new reporting provision applies to financial
years ending on or after 31 March 2016. The Board are taking
steps to incorporate appropriate and proportionate controls.

Management Teams
During 2015 the Board delegated management of the business
to the Corporate Organisation Team. The Executive Team, which
comprises the Executive Directors, is the Chief Operating
Decision Maker and attended the Corporate Organisation Team
and Review and Planning team meetings.

Alliance Pharma plc | Annual Report 2015 21

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Reporting Structure
Committees

The Board has an Audit Committee, a Nominations Committee and
a Remuneration Committee, each with written terms of reference.
The terms of reference are available on the Group website. The
Report of the Remuneration Committee and Report of the
Nominations Committee form part of this governance section. Each
Committee reports to the Board on its activities.

Meetings

The Board meets regularly on pre-determined dates and has a
strategy meeting each year consisting of the Board and other
Senior Managers, the purpose of which is to discuss progress on
the strategy, to review the long-term strategy and develop the
strategic framework for the achievement of the Group’s targets.
During 2015 the Board held 11 scheduled meetings. Thomas
Casdagli, David Cook and Anthony Booley attended ten scheduled
Board meetings, Andrew Franklin attended all the Board meetings
since his appointment on 28 September, and Nigel Clifford attended
eight Board meetings since his appointment. All other members of
the Board attended all the scheduled meetings. In addition there
were a number of ad-hoc meetings.

Non-Executive Directors
The role of the Non-Executive Directors is to:

l    Challenge constructively and help develop proposals on strategy

l    Satisfy themselves as to the financial integrity of the financial

information

l    Satisfy themselves as to the robustness of the controls

l    Ensure that the systems of risk management are robust 

and defensible

l    Review management performance and the monitoring and

reporting of such performance.

They have a role in determining the pay and benefits of the
Executive Directors, to play a key role in the appointment and, if
necessary, removal of Executive Directors and Board succession.

Remuneration Committee
The members of the Remuneration Committee are: 

Andrew Smith (Chairman of the Remuneration Committee)

Thomas Casdagli

David Cook

Nigel Clifford (appointed 24 February 2015)

The Company Secretary attends the meetings of the Remuneration
Committee as Secretary to the Remuneration Committee. The Chief
Executive Officer and the Chief Human Resources Officer are also
invited to attend certain meetings of the Remuneration Committee.

There were five Remuneration Committee meetings held during 
the year.

The Large and Medium-sized Companies and Groups (Accounts
and Reports) (Amendment) Regulations 2013 do not apply to
companies quoted on AIM; the Remuneration Committee is
committed to use the Regulations to influence the Report and
follow best practice where appropriate.

The terms of reference of the Remuneration Committee are
available on www.alliancepharma.co.uk

Role of the Remuneration Committee
The Remuneration Committee reviews and determines on behalf 
of the Board and shareholders of the Company the pay, benefits
and other terms of service of the Executive Directors of the
Company and the broad pay strategy with respect to senior
Company employees.

Remuneration Policy
The objective of the Company’s remuneration policy is to attract
and retain the Directors and senior executives needed to run the
Company in a cost-effective manner.

The remuneration policy of the Company has four principal
components:

1.  Basic Salaries and Benefits in Kind – Basic salaries are

determined by the Remuneration Committee bearing in mind
the salaries paid in AIM-listed and other small market
capitalisation healthcare companies. Within that frame of
reference, it is intended that pay should be at or near the
median level. Benefits in kind include the provision of company
cars (or a salary alternative).

2.  Bonuses – Bonuses are payable to staff according to the

achievement by the Group of certain pre-determined earnings
targets. The level of bonuses payable on achievement of the
targets is set at the level perceived appropriate to provide the
necessary incentives for Executive Directors and Senior
Managers. There are appropriate adjustments to the bonus
payable in the event of over- or under-achievement of the 
Group against those targets. In addition, bonuses are adjusted
for personal performance and the amount of bonus paid will
reflect any substantial periods of absence or unavailability of 
the employee.

3.  Share Options Scheme – The Company has in place a share
option scheme covering all employees, under which share
options are normally granted once a year. The exercise price of
the options granted under the scheme is set equal to the
market value of the Company's shares at the time of grant. 
The share option scheme is overseen by the Remuneration
Committee which shall determine the terms under which
eligible individuals may be invited to participate. The scheme is
normally an HMRC approved scheme but may be unapproved in
relation to certain individuals. Share Options granted to senior
managers include a company performance element.

4.  Pensions – There is a defined contribution scheme for all

Executive Directors and employees. Only basic salaries are
pensionable, except in the case of Tony Booley, whose bonus is
also pensionable. 

Gender Pay Transparency Report 
The Remuneration Committee will consider the Regulations under
the Equality Act 2010 on Gender Pay Transparency in 2016.

Diversity Policy Reporting
Listed companies will also be required to include in their corporate
governance statement a description of the board diversity policy
applied with regard to aspects such as age, gender or educational
and professional backgrounds, the objectives of that diversity
policy, how it has been implemented and the results in the
reporting period. 

 
 
 
22 Alliance Pharma plc | Annual Report 2015         

Directors’ Remuneration

Directors’ Remuneration
The aggregate remuneration payable to the directors during the period was as follows:

                                                              Salary                                  Bonus                                   Other                                Pension               Total Remuneration
£                                               2015              2014              2015               2014              2015              2014              2015              2014              2015              2014

A R Booley                     195,301        182,057         62,131            7,789       370,291            6,483                    -            2,403       627,723        198,732
P J Butterfield               175,065        161,600         92,438          10,219               537               520         16,553          15,140       284,593        187,479
T Casdagli                                  -                    -                    -                    -                    -                    -                    -                    -                    -                    -
J Dawson                       219,614        212,677         96,680            8,014            1,922            5,332         10,000          10,000       328,216        236,023
A T Franklin                     38,802                    -            9,807                    -                    -                    -            2,333                    -         50,942                    -
M R B Gatenby                           -          29,277                    -                    -                    -               832                    -                    -                    -          30,109
P M Ranson                               -          34,404                    -                    -                    -                    -                    -                    -                    -          34,404
A L Smith                         74,003          56,134                    -                    -                    -            1,611                    -                    -         74,003          57,745
R D Wright                       65,389        155,606                    -            5,720       147,353            1,767            6,114          14,372       218,856        177,465
D Cook                              37,474          25,910                    -                    -               657               318                    -                    -         38,131          26,228
N Clifford                         33,997                    -                    -                    -               562                    -                    -                    -         34,559                    -

                                       839,645        857,665       261,056          31,742       521,322          16,863         35,000          41,915    1,657,023        948,185

                                                                                                                                           Total Remuneration      Share based payments                   Total
£                                                                                                                                             2015              2014              2015              2014              2015              2014

A R Booley                                                                                                          627,723        198,732         24,713          35,013       652,436        233,745
P J Butterfield                                                                                                    284,593        187,479         25,272          55,092       309,865        242,571
T Casdagli                                                                                                                       -                    -                    -                    -                    -                    -
J Dawson                                                                                                            328,216        236,023                    -                    -       328,216        236,023
A T Franklin                                                                                                          50,942                    -            5,435                    -         56,377                    -
M R B Gatenby                                                                                                                -          30,109                    -                    -                    -          30,109
P M Ranson                                                                                                                    -          34,404                    -                    -                    -          34,404
A L Smith                                                                                                              74,003          57,745                    -                    -         74,003          57,745
R D Wright                                                                                                          218,856        177,465         13,968          35,013       232,824        212,478
D Cook                                                                                                                   38,131          26,228                    -                    -         38,131          26,228
N Clifford                                                                                                               34,559                    -                    -                    -         34,559                    -

                                                                                                                         1,657,023        948,185         69,388        125,118    1,726,411     1,073,303

Directors’ Service Contracts
All Executive Directors are employed under service contracts. 
The services of all Executive Directors may be terminated by the
provision of a maximum of 12 months’ notice by the Company.

On 23 November 2015, it was announced that Tony Booley would
leave the Company. As part of Mr Booley’s settlement agreement a
payment of £362,000 has been accrued in relation to payment in
lieu of notice and loss of office that is expected to be paid in 2016.

Loss of Office Payments
Richard Wright resigned from the Board on 29 May 2015. Until that
date he received his base salary and benefits. As part of Mr
Wright’s settlement agreement a payment of £146,100 in lieu of
notice was made.

Alliance Pharma plc | Annual Report 2015 23

Directors’ Share Options
Details of options for the Directors who served during the year are as follows:

                                                                              2014                               Granted                                 2015
                                                                                     Not subject to             Subject to     Not subject to             Subject to     Not subject to             Subject to                Exercise             Date from
                                                                                       performance       performance       performance       performance       performance       performance                      price                    which                    Expiry
Number
                                                                                             conditions            conditions            conditions            conditions            conditions            conditions                  (pence)          exercisable                       date

A R Booley                                          110,000                   -                   -                   -       110,000                     -              7.75      13/04/12      12/04/19
                                                            116,500                   -                   -                   -       116,500                     -            34.25      29/04/13      28/04/20
                                                            130,000                   -                   -                   -       130,000                     -            34.12      28/04/14      27/04/21
                                                            140,000                   -                   -                   -       140,000                     -            29.25      19/10/15      18/10/22
                                                            144,200                   -                   -                   -       144,200                     -            37.25      06/06/16      05/06/23
                                                                       -        400,000                   -                   -                   -        400,000            35.75      23/10/18      22/10/23
                                                            144,200                   -                   -                   -       144,200                                   33.75      11/04/17      10/04/24
                                                                       -                   -        149,653                   -       149,653                                   43.75      27/05/18      26/05/25

P J Butterfield                                 1,000,000                   -                   -                   -    1,000,000                     -            33.25      26/03/13      25/03/20
                                                            115,000                   -                   -                   -       115,000                     -            34.25      29/04/13      28/04/20
                                                         1,130,000                   -                   -                   -    1,130,000                     -            34.12      28/04/14      27/04/21
                                                            140,000                   -                   -                   -       140,000                     -            29.25      19/10/15      18/10/22
                                                            144,200                   -                   -                   -       144,200                     -            37.25      06/06/16      05/06/23
                                                                       -        400,000                   -                   -                   -        400,000            35.75      23/10/18      22/10/23
                                                            144,200                   -                   -                   -       144,200                                   33.75      11/04/17      10/04/24
                                                                       -                   -        166,625                   -       166,625                     -            43.75      27/05/18      26/05/25

A T Franklin                                                   -                   -     2,000,000                   -    2,000,000                     -            46.75      04/12/18      03/12/25

No Director exercised any options during the year except Richard Wright who exercised 248,650 shares under the share option scheme.
A further 828,400 share options were forfeited by Mr Wright.

The market price of ordinary shares at 31 December 2015 was 43.00 pence and the range during the period was from 33.75 pence to
61.13 pence.

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Nominations Committee
The Nominations Committee met five times during the year. Nigel
Clifford attended the 4 meetings following his appointment.
Thomas Casdagli and David Cook attended 4 meetings. Other
members attended all the meetings. 

The Committee focused heavily on Board succession with the key
outcome of the appointment on 28 September 2015 of Andrew
Franklin as Chief Financial Officer. The Committee appointed
Boyden Executive Search to compile a short list of candidates for
this vacancy. Boyden has no other connection with the Company. 

The Committee acknowledges that diversity is a benefit to the
Company and bears this in mind when recruiting any role. By this
approach, the Company seeks to recruit the best individual for the
role, but has not implemented a policy of positive discrimination by
forms of measurable diversity objectives. 

Audit Committee
The Audit Committee met three times during the year. All
members attended all the meetings. 

The external auditors attend the meetings to discuss the planning
and conclusions of their audits and reviews and meet with the
members of the Committee without any members of the Executive
present after each meeting.

The Audit Committee is able to call for information from
management and consults with the external auditors directly if
required.

The Audit Committee operates within specific terms of reference
which include:

l    considering the appointment of external auditors

l    reviewing the relationship with external auditors

l    reviewing the financial reporting and internal control

procedures

l    reviewing the management of financial matters and focusing

upon the independence and objectivity of the external auditors

l    reviewing the consistency of accounting policies both on a year

to year basis and across the Group

As a result of the increased size of the Group following the
acquisition of assets and businesses from Sinclair IS Pharma, a
newly-formed Risk Review Committee will report to the Audit
Committee and to the Senior Leadership Team.

 
 
 
24 Alliance Pharma plc | Annual Report 2015         

Other Matters

Principal activities
The principal activity of the Group is the acquisition, marketing and distribution of pharmaceutical products. The principal activity of the
Company is to act as a holding company.

Directors
The following table shows the beneficial interests of the Directors (and their spouses and minor children) in the shares of the
Company.

                                                                                                                                                    Ordinary shares
                                                                                       Beneficial                     Non-beneficial                                                               At start of year or
                                                                                           interest                                  interest                   At end of year      subsequent appointment
                                                                                          Number                                Number                             Number                                   Number

Anthony Booley                                                              2,055,723                                             -                           2,055,723                                 4,310,723
Peter Butterfield                                                                          -                                             -                                          -                                                -
Thomas Casdagli                                                                78,518                             55,483,382                         55,561,900                               24,061,900
John Dawson                                                               39,576,402                             20,000,000                         59,576,402                               59,576,402
Nigel Clifford                                                                     180,663                                             -                              180,663                                                -
David Cook                                                                                    -                                             -                                          -                                                -
Andrew Franklin                                                                           -                                             -                                          -                                                -
Andrew Smith                                                                   275,000                                             -                              275,000                                    200,000

Directors’ Responsibilities Statement
The Directors are responsible for preparing the Strategic Report
and the Directors’ Report and the financial statements in
accordance with applicable law and regulations.

Company law requires the Directors to prepare financial
statements for each financial year. Under that law the Directors
have elected to prepare the Group financial statements and the
Company financial statements in accordance with International
Financial Reporting Standards as adopted by the European Union
(IFRSs). Under company law the Directors must not approve the
financial statements unless they are satisfied that they give a true
and fair view of the state of affairs and profit or loss of the
Company and Group for that period. In preparing these financial
statements, the Directors are required to:

l    select suitable accounting policies and then apply them

consistently;

l    make judgements and accounting estimates that are

reasonable and prudent;

l    state whether applicable IFRSs have been followed, subject to

any material departures disclosed and explained in the
financial statements;

l    prepare the financial statements on the going concern basis
unless it is inappropriate to presume that the Company will
continue in business.

The Directors are responsible for keeping adequate accounting
records that are sufficient to show and explain the Company’s
transactions and disclose with reasonable accuracy at any time
the financial position of the Company and enable them to ensure
that the financial statements comply with the Companies Act 2006.
They are also responsible for safeguarding the assets of the
Company and hence for taking reasonable steps for the prevention
and detection of fraud and other irregularities.

The Directors confirm that: 

l    so far as each of the Directors is aware there is no relevant

audit information of which the Company’s auditor is unaware;
and

l    the Directors have taken all steps that they ought to have taken
to make themselves aware of any relevant audit information
and to establish that the auditors are aware of that information.

The Directors are responsible for the maintenance and integrity of
the corporate and financial information included on the Company’s
website. Legislation in the United Kingdom governing the
preparation and dissemination of financial statements may differ
from legislation in other jurisdictions. 

Alliance Pharma plc | Annual Report 2015 25

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Disabled employees
Applications for employment by disabled persons are fully
considered, bearing in mind the aptitudes of the applicant
concerned. In the event of members of staff becoming disabled,
every effort is made to ensure that their employment with the
Group continues and that appropriate training is arranged. It is the
policy of the Group that the training, career development and
promotion of disabled persons should, as far as possible, be
identical to that of other employees.

Employee information and consultation
The Group continues to involve its staff in the future development
of the business. Information is provided to employees through the
Group website, intranet site and by regular monthly briefing
meetings.

The Group operates a Group Personal Pension Plan and a
Stakeholder Pension Plan which is available to all employees.

Going concern
As explained in the Strategic Report, the current rate of cash
generation by the Group comfortably exceeds the capital and debt
servicing needs of the business (though there cannot, of course,
be absolute certainty that the rate of cash generation will be
maintained). The Board remains confident that all the bank
covenants will continue to be met. The Group has a £5m Working
Capital Facility which is largely undrawn and which the Board
believes should comfortably satisfy the Group’s working capital
needs for at least the next 12 months.

After making enquiries, the Directors have formed a judgement
that there is reasonable expectation that the Group has adequate
resources to continue in operational existence for the foreseeable
future. For this reason, the Directors continue to adopt the going
concern basis in preparing the financial statements.

Political donations
There were no political donations made during the period.

Auditor
A resolution to re-appoint Grant Thornton UK LLP as auditor for
the next year will be proposed at the annual general meeting in
accordance with section 489 of the Companies Act 2006.

Annual General Meeting
The 2016 Annual General Meeting of the Company will be held on
25 May 2016, the business of which is set out in the Notice of
Meeting.

On behalf of the Board

Sarah Robinson
Company Secretary
6 April 2016

 
 
 
26 Alliance Pharma plc | Annual Report 2015         

Independent Auditor’s report to 
the members of Alliance Pharma plc

Opinion on other matter prescribed by the
Companies Act 2006
In our opinion the information given in the Strategic Report and
Directors' Report for the financial year for which the financial
statements are prepared is consistent with the financial
statements.

Matters on which we are required to report by
exception
We have nothing to report in respect of the following matters
where the Companies Act 2006 requires us to report to you if, in
our opinion:

l    adequate accounting records have not been kept by the

Parent Company, or returns adequate for our audit have not
been received from branches not visited by us; or

l    the Parent Company financial statements are not in

agreement with the accounting records and returns; or

l    certain disclosures of Directors’ remuneration specified by

law are not made; or

l    we have not received all the information and explanations 

we require for our audit.

Tracey D James
Senior Statutory Auditor
for and on behalf of Grant Thornton UK LLP
Statutory Auditor, Chartered Accountants
Oxford
6 April 2016

We have audited the financial statements of Alliance Pharma plc
for the year ended 31 December 2015 which comprise the
consolidated income statement, the consolidated statement of
comprehensive income, the consolidated balance sheet, the
company balance sheet, the consolidated statement of changes
in equity, the company statement of changes in equity, and the
consolidated and company cash flow statements and the related
notes. The financial reporting framework that has been applied
in their preparation is applicable law and International 
Financial Reporting Standards (IFRSs) as adopted by the
European Union and, as regards the Parent Company financial
statements, as applied in accordance with the provisions of the
Companies Act 2006.

This report is made solely to the Company’s members, as a
body, in accordance with Chapter 3 of Part 16 of the Companies
Act 2006. Our audit work has been undertaken so that we might
state to the Company’s members those matters we are required
to state to them in an auditor’s report and for no other purpose.
To the fullest extent permitted by law, we do not accept or
assume responsibility to anyone other than the Company and
the Company’s members as a body, for our audit work, for this
report, or for the opinions we have formed.

Respective responsibilities of Directors and auditor
As explained more fully in the Directors’ Responsibilities
Statement, the Directors are responsible for the preparation of
the financial statements and for being satisfied that they give a
true and fair view. Our responsibility is to audit and express an
opinion on the financial statements in accordance with
applicable law and International Standards on Auditing (UK and
Ireland). Those standards require us to comply with the Auditing
Practices Board’s (APB’s) Ethical Standards for Auditors.

Scope of the audit of the financial statements
A description of the scope of an audit of financial statements is
provided on the Financial Reporting Council's website at
www.frc.org.uk/auditscopeukprivate.

Opinion on financial statements
In our opinion:

l    the financial statements give a true and fair view of the state
of the Group's and of the Parent Company's affairs as at 31
December 2015 and of the Group's profit for the year then
ended; 

l    the Group financial statements have been properly prepared
in accordance with IFRSs as adopted by the European Union;
and

l    the Parent Company financial statements have been properly

prepared in accordance with IFRSs as adopted by the
European Union and as applied in accordance with the
provisions of the Companies Act 2006; and

l    the financial statements have been prepared in accordance

with the requirements of the Companies Act 2006.

Alliance Pharma plc | Annual Report 2015 27

Consolidated Income Statement

                                                                                                                  Year ended 31 December 2015                    Year ended 31 December 2014     

                                                                                                                                           Non-                                                               Non-                        
                                                                                                        Underlying    Underlying               Total     Underlying     Underlying                Total
                                                                                            Note                                   (note 5)                                                              (note 5)                        
                                                                                                                 £000s               £000s               £000s              £000s              £000s              £000s

Revenue                                                                                   3            48,344                         -              48,344             43,536                      -             43,536
Cost of sales                                                                                        (19,614)                         -           (19,614)           (18,493)                      -           (18,493)

Gross profit                                                                                            28,730                         -              28,730             25,043                      -             25,043

Operating expenses
Administration and marketing expenses                                         (15,634)             (1,846)           (17,480)           (12,510)                      -           (12,510)
Amortisation of intangible assets                                                           (199)                         -                 (199)                (488)                      -                (488)
Share-based employee remuneration                                  7               (615)                         -                 (615)                (571)                      -                (571)
Share of joint venture profits                                                                     194                         -                   194                  319                      -                  319

                                                                                                               (16,254)             (1,846)           (18,100)           (13,250)                      -           (13,250)

Operating profit/(loss) excluding exceptional item                          12,476             (1,846)              10,630             11,793                      -             11,793
Exceptional item                                                                      5                      -                6,332                6,332                      -                (622)                (622)

Operating profit                                                                                     12,476                4,486              16,962             11,793                (622)             11,171

Finance costs                              
Interest payable and similar charges                                    6            (1,221)                 (750)             (1,971)             (1,090)                      -             (1,090)
Interest income                                                                        6                  139                         -                   139                    48                      -                    48
Other finance income                                                              6                    52                         -                      52                    28                      -                    28

                                                                                                                (1,030)                 (750)             (1,780)             (1,014)                      -             (1,014)

Profit on ordinary activities before taxation                       4            11,446                3,736              15,182             10,779                (622)             10,157
Taxation                                                                                    8            (1,375)             (1,115)             (2,490)             (1,896)                  124             (1,772)

Profit for the year attributable to equity shareholders                   10,071                2,621              12,692               8,883                (498)               8,385

Earnings per share                    
Basic (pence)                                                                         10                                                                     4.65                                                                 3.17
Diluted (pence)                                                                       10                                                                     4.55                                                                 3.16

All of the activities of the Group are classed as continuing.
The accompanying accounting policies and notes form an integral part of these financial statements.

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28 Alliance Pharma plc | Annual Report 2015         

Consolidated Statement of Comprehensive Income

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Profit for the period                                                                                                                                                                                12,692                         8,385

Other comprehensive income

Items that may be reclassified to profit or loss                                                                                                                                                                      
Foreign exchange revaluations                                                                                                                                                            32                               7
Interest rate swaps – cash flow hedge                                                                                                                                                 9                        (572)
Deferred tax on interest rate swaps                                                                                                                                                   (4)                           119
Share of Joint Venture other comprehensive loss                                                                                                                               -                            (8)

Total comprehensive income for the period                                                                                                                             12,729                        7,931

Alliance Pharma plc | Annual Report 2015 29

Consolidated Balance Sheet

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                           Note                      £000s                      £000s  

Assets                                                                                                                                                                                                                                                        
Non-current assets                                                                                                                                                                                                                   
Intangible assets                                                                                                                                                   11                   259,945                     88,875
Property, plant and equipment                                                                                                                           12                       1,013                           396
Joint Venture investment                                                                                                                                     33                       1,465                        1,271
Joint Venture receivable                                                                                                                                       33                       1,462                        1,462
Deferred tax asset                                                                                                                                                23                          418                           194
Other non-current assets                                                                                                                                                                  122                               -

                                                                                                                                                                                                      264,425                     92,198
Current assets
Inventories                                                                                                                                                             14                     12,910                        5,914
Trade and other receivables                                                                                                                                15                     11,630                        8,322
Cash and cash equivalents                                                                                                                                  16                       3,229                        1,434

                                                                                                                                                                                                        27,769                     15,670

Total assets                                                                                                                                                                                  292,194                   107,868

Equity
Ordinary share capital                                                                                                                                          25                       4,682                        2,641
Share premium account                                                                                                                                                             108,308                     29,388
Share option reserve                                                                                                                                                                       2,610                        1,995
Reverse takeover reserve                                                                                                                                                                (329)                        (329)
Other reserve                                                                                                                                                                                      (98)                        (103)
Translation reserve                                                                                                                                                                               32                               -
Retained earnings                                                                                                                                                                         47,237                     37,188

Total equity                                                                                                                                                                                  162,442                     70,780

Liabilities
Non-current liabilities
Long term financial liabilities                                                                                                                             19                     58,968                     19,235
Other liabilities                                                                                                                                                      20                       1,496                               -
Deferred tax liability                                                                                                                                             23                     37,413                        6,309
Derivative financial instruments                                                                                                                         22                          120                           129

                                                                                                                                                                                                        97,997                     25,673
Current liabilities                                                                                                                                                                                                                        
Cash and cash equivalents                                                                                                                                  16                            31                           414
Financial liabilities                                                                                                                                               19                     15,776                        2,895
Corporation tax                                                                                                                                                                                2,075                           959
Trade and other payables                                                                                                                                    18                     13,873                        6,920
Provisions for other liabilities                                                                                                                             24                               -                           227

                                                                                                                                                                                                        31,755                     11,415

Total liabilities                                                                                                                                                                             129,752                     37,088

Total equity and liabilities                                                                                                                                                         292,194                   107,868

The financial statements were approved by the Board of Directors on 6 April 2016.

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John Dawson                                                                  Andrew Franklin                                                                 
Director                                                                        Director

The accompanying accounting policies and notes form an integral part of these financial statements. Company number 04241478.

 
30 Alliance Pharma plc | Annual Report 2015        

Company Balance Sheet

                                                                                                                                                                            31 December 2015        31 December 2014
                                                                                                                                                             Note                             £000s                              £000s

Assets
Non-current assets                                                                                                                 
Investment in subsidiaries                                                                                                                    13                          138,569                               51,936

                                                                                                                                                                                                    138,569                             51,936
Current assets                                                                                                                                                                                   
Trade and other receivables                                                                                                                  15                                   26                                       25
Cash and cash equivalents                                                                                                                    16                                      -                                       12

                                                                                                                                                                                                              26                                    37

Total assets                                                                                                                                                                          138,595                             51,973

Equity                                                                                                                                                                                                   
Ordinary share capital                                                                                                                            25                              4,682                               2,641
Share premium account                                                                                                                                                      108,308                             29,388
Share option reserve                                                                                                                                                                2,610                               1,995
Retained earnings                                                                                                                                                                  22,394                             17,766

Total equity                                                                                                                                                                           137,994                             51,790

Liabilities                                                                                                                                                                                                        
Current liabilities                                                                                                                                                                              
Trade and other payables                                                                                                                      18                                 571                                  183
Cash and cash equivalents                                                                                                                    16                                   30                                      -

                                                                                                                                                                                                       601                                  183

Total liabilities                                                                                                                                                                             601                                  183

Total equity and liabilities                                                                                                                                                 138,595                             51,973

The financial statements were approved by the Board of Directors on 6 April 2016.

John Dawson                                                                  Andrew Franklin                                                                 
Director                                                                        Director

The accompanying accounting policies and notes form an integral part of these financial statements. Company number 04241478.

Alliance Pharma plc | Annual Report 2015 31

Consolidated Statement of Changes in Equity

                                                                                      Ordinary            Share            Share       Reverse
                                                                                           share     premium           option      takeover            Other   Translation    Retained             Total
                                                                                         capital        account        reserve        reserve        reserve          reserve    earnings           equity
                                                                                           £000s           £000s           £000s           £000s           £000s             £000s          £000s           £000s

Balance 1 January 2014                                              2,641          29,380            1,424             (329)               350                     -         31,202          64,668

Issue of shares                                                                     -                   8                    -                    -                    -                     -                  -                   8
Dividend paid                                                                        -                    -                    -                    -                    -                     -         (2,398)          (2,398)
Share options charge                                                          -                    -               571                    -                    -                     -                  -               571

Transactions with owners                                                   -                   8               571                    -                    -                     -         (2,398)          (1,819)

Profit for the period                                                             -                    -                    -                    -                    -                     -           8,385            8,385
Other comprehensive income                                                                                                                                                        
Interest rate swaps – cash flow hedge                              -                    -                    -                    -             (572)                     -                  -             (572)
Deferred tax on interest rate swap                                    -                    -                    -                    -               119                     -                  -               119
Foreign exchange translation differences                        -                    -                    -                    -                    -                     -                (1)                 (1)

Total comprehensive income for the period                   -                    -                    -                    -             (453)                     -           8,384            7,931

Balance 31 December 2014                                        2,641          29,388            1,995             (329)             (103)                     -         37,188          70,780

Balance 1 January 2015                                              2,641          29,388            1,995             (329)             (103)                     -         37,188          70,780

Issue of shares                                                             2,041                    -                    -                    -                    -                     -                  -            2,041
Share premium                                                                    -          78,920                    -                    -                    -                     -                  -          78,920
Dividend paid                                                                        -                    -                    -                    -                    -                     -         (2,643)          (2,643)
Share options charge                                                          -                    -               615                    -                    -                     -                  -               615

Transactions with owners                                           2,041          78,920               615                    -                    -                     -         (2,643)          78,933

Profit for the period                                                             -                    -                    -                    -                    -                     -         12,692          12,692
Other comprehensive income                                                                                                                                                        
Interest rate swaps – cash flow hedge                              -                    -                    -                    -                   9                     -                  -                   9
Deferred tax on interest rate swap                                    -                    -                    -                    -                 (4)                     -                  -                 (4)
Foreign exchange translation differences                        -                    -                    -                    -                    -                   32                  -                 32

Total comprehensive income for the period                   -                    -                    -                    -                   5                   32         12,692          12,729

Balance 31 December 2015                                       4,682        108,308             2,610             (329)                (98)                    32         47,237        162,442

The balance on the share premium account may not be legally distributed under section 831 of the Companies Act 2006.

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32 Alliance Pharma plc | Annual Report 2015         

Company Statement of Changes in Equity 

                                                                                                                                                          Ordinary            Share           Share
                                                                                                                                                               share     premium           option      Retained             Total
                                                                                                                                                             capital        account        reserve      earnings           equity
                                                                                                                                                               £000s           £000s           £000s            £000s           £000s

Balance 1 January 2014                                                                                                              2,641          29,380            1,424          13,527          46,972

Issue of shares                                                                                                                                    -                   8                    -                    -                   8
Dividend paid                                                                                                                                       -                    -                    -          (2,398)          (2,398)
Share options charge                                                                                                                          -                    -               571                    -               571

Transactions with owners                                                                                                                  -                   8               571          (2,398)          (1,819)

Profit for the period and total comprehensive income                                                                   -                    -                    -            6,637            6,637

Balance 31 December 2014                                                                                                        2,641          29,388            1,995          17,766          51,790

Balance 1 January 2015                                                                                                              2,641          29,388            1,995          17,766          51,790

Issue of shares                                                                                                                             2,041                    -                    -                    -            2,041
Share premium                                                                                                                                    -          78,920                    -                    -          78,920
Dividend paid                                                                                                                                       -                    -                    -          (2,643)          (2,643)
Share options charge                                                                                                                          -                    -               615                    -               615

Transactions with owners                                                                                                           2,041          78,920               615          (2,643)          78,933

Profit for the period and total comprehensive income                                                                   -                    -                    -            7,271            7,271

Balance 31 December 2015                                                                                                      4,682        108,308             2,610           22,394        137,994

The balance on the share premium account may not be legally distributed under section 831 of the Companies Act 2006.

The profit for the year dealt with in the financial statements of the Parent Company was £7,271,000 (2014: £6,637,000).

As permitted by section 408 of the Companies Act 2006, no separate income statement is presented in respect of the Parent Company.

Alliance Pharma plc | Annual Report 2015 33

Consolidated and Company Cash Flow Statements

                                                                                                                                                                                Group                                             Company
                                                                                                                                            Year ended         Year ended        Year ended         Year ended
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                           Note                  £000s                  £000s                  £000s                  £000s

Cash flows from operating activities
Cash generated from operations                                                                        27                   9,836                 13,451                      476                        50
Tax paid                                                                                                                                      (1,860)                 (2,028)                           -                           -

Cash flows received from operating activities                                                                         7,976                 11,423                      476                        50

Investing activities
Interest received                                                                                                                             139                        48                   2,097                   1,757
Dividend received                                                                                                                                -                        72                   5,700                   5,400
Investment in subsidiary                                                                                                                    -                           -              (86,632)                 (4,817)
Development costs capitalised                                                                           11                        (7)                      (58)                           -                           -
Purchase of property, plant and equipment                                                      12                   (647)                    (111)                           -                           -
Purchase of other intangible assets                                                                                  (133,629)                 (2,817)                           -                           -
Net assets acquired on acquisition                                                                                           (221)                           -                           -                           -
Investment in Joint Venture                                                                                                               -                    (499)                           -                           -

Net cash (used in) / received from investing activities                                                     (134,365)                 (3,365)              (78,835)                   2,340

Financing activities
Interest paid and similar charges                                                                                           (1,163)                    (986)                           -                           -
Loan issue costs                                                                                                                       (1,174)                           -                           -                           -
Loan to Joint Venture                                                                                                                          -                    (503)                           -                           -
Proceeds from issue of shares                                                                                                83,500                           -                 83,500                           -
Costs incurred on issue of shares                                                                                          (2,661)                           -                (2,661)                           -
Proceeds from exercise of share options                                                                                    121                          8                      121                          8
Dividend paid                                                                                                                             (2,643)                 (2,398)                (2,643)                 (2,398)
Receipt from borrowings                                                                                                          80,500                   2,750                           -                           -
Repayment of borrowings                                                                                                     (28,000)                 (4,500)                           -                           -

Net cash received from / (used in) financing activities                                                       128,480                 (5,629)                 78,317                 (2,390)

Net movement in cash and cash equivalents                                                                         2,091                   2,429                     (42)                           -

Cash and cash equivalents at the beginning of the period                                                  1,020                 (1,438)                        12                        12
Exchange gains on cash and cash equivalents                                                                             87                        29                           -                           -

Cash and cash equivalents at the end of the period                                      16                   3,198                   1,020                     (30)                        12

The accompanying accounting policies and notes form an integral part of these financial statements. 

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34 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements
for year ended 31 December 2015

1. General information
Alliance Pharma plc (‘the Company’) and its subsidiaries (together ‘the Group’) acquire, market and distribute pharmaceutical and
other medical products. The Company is a public limited company incorporated and domiciled in England. The address of its
registered office is Avonbridge House, Bath Road, Chippenham, Wiltshire, SN15 2BB. 

The Company is listed on the AIM stock exchange.

These consolidated financial statements have been approved for issue by the Board of Directors on 6 April 2016.

2. Summary of significant accounting policies
The principal accounting policies applied in the preparation of these consolidated financial statements are set out below. These
policies have been consistently applied to all the periods presented.

2.1 Basis of preparation

These financial statements have been prepared in accordance with International Financial Reporting Standards as adopted by the EU
and with those parts of the Companies Act 2006 applicable to companies reporting under IFRS. The financial statements have been
prepared under the historical cost convention, with the exception of derivatives which are included at fair value. A summary of the
more important Group and Company accounting policies are set out below. The preparation of financial statements in conformity with
generally accepted accounting principles requires the use of estimates and assumptions in these statements, particularly in relation
to determining the useful economic life of assets, that affect the reported amounts of assets and liabilities at the date of the financial
statements and the reported amounts of revenues and expenses during the reporting period. Although these estimates are based on
management’s best knowledge of the amount, event or actions, actual results ultimately may differ from those estimates.

2.2 Consolidation

The consolidated balance sheet includes the assets and liabilities of the Company and its subsidiaries which are made up to 31
December 2015. Entities over which the Group has the ability to exercise control are accounted for as subsidiaries. Interests acquired
in entities are consolidated from the effective date of acquisition and interests sold are consolidated up to the date of disposal.
Balances between Group companies are eliminated; no profit is taken on sales between Group companies. Goodwill arising on the
acquisition of interests in subsidiaries, representing the excess of consideration transferred over the Group's share of the fair values
of identifiable assets, liabilities and contingent liabilities acquired, is capitalised as a separate item.

An entity is treated as a Joint Venture where the Group holds a long-term interest and shares control under a contractual agreement.
Following IFRS 11 the Group now accounts for its investment in Joint Ventures using the equity method in accordance with IAS 28. See
note 33 for details of Joint Ventures. The consolidated income statement includes the Group’s share of the Joint Ventures’ profit. 

2.3 Judgements and estimates

The preparation of the consolidated financial statements requires management to make judgements, estimates and assumptions that
affect the application of policies and reported amounts of assets and liabilities, income and expenses. The estimates and associated
assumptions are based on historical experience and various other factors that are believed to be reasonable under the circumstances.
Actual results may differ from these estimates. 

The estimates and underlying assumptions are reviewed on an on-going basis. Revisions to accounting estimates are recognised in
accordance with IAS 8 ‘Accounting Policies, Changes in Accounting Estimates and Errors’. Critical judgements, estimates and
assumptions that are applied in the preparation of the consolidated financial statements include:

Depreciation and amortisation
The Group exercises judgement to determine useful lives and residual values of intangibles, computer equipment, and fixtures, fittings
and equipment. The assets are depreciated down to their residual values over their estimated useful lives.

Impairment
The value in use calculation uses cash flow projections based on financial forecasts for the next two years approved by management
and extrapolated for a 15 year period or the useful economic life, whichever is the shorter. In each case it is assumed there will be no
growth beyond 2017 and the cash flows of each acquisition are discounted at a rate of 10%, which approximates to the Group’s
weighted average cost of capital (see note 11). 

Provisions
Provisions have been made for slow moving and obsolete stock. These provisions are estimates and the actual costs and timing of
future cash flows are dependent on future events. The difference between expectations and the actual future liability will be accounted
for in the period when such determination is made.

Consolidation of Joint Ventures
The Group owns 60% of the issued share capital of Unigreg Limited. The Group considered the existence of substantive participating
rights held by the minority shareholder which provide that shareholder with a veto right over the significant financial and operating 

Alliance Pharma plc | Annual Report 2015 35

2. Summary of significant accounting policies continued
policies of Unigreg Ltd and determined that, as a result of these rights, the Group does not have control over the financial and
operating policies of Unigreg Ltd, despite the Group's 60% ownership interests. Consequently the Company is accounted for as a 
Joint Venture.

The Group owns 20% of the issued share capital of Synthasia International Company Limited (‘Synthasia’). The Group considered the
existence of substantive participating rights held by both the Group and another shareholder which provide both parties with a veto
right over the significant financial and operating policies of Synthasia and determined that, as a result of these rights, Synthasia is
accounted for as a Joint Venture.

In accordance with IFRS 11, the Group’s investments made to date in joint arrangements are characterised as Joint Ventures in which
the Group has rights to a share of the arrangement’s net assets rather than direct rights to underlying assets and obligation for
underlying liabilities.

Segmental reporting
All business areas are responsible for developing, marketing and distributing a range of pharmaceutical and other medical products.
As permitted by IFRS 8, since these business areas are deemed to have similar economic characteristics and are similar, if not the
same, in all of the following:

l    business areas derive their revenue from the supply of pharmaceutical products;

l    the production and distribution process is the same across all business areas;

l    business areas supply to similar customers i.e. pharmaceutical distributors or pharmacies; and

l    all business areas are subject to a similar regulatory environment.

The business areas have been aggregated into a single reportable segment, namely pharmaceuticals. 

Intangibles
Where there are national governmental pricing controls in place, the Group has the ability to increase pricing of certain products and
reduce pricing of others. When this occurs, the intangible assets associated to each product are grouped for impairment testing
purposes. 

Unigreg Ltd, has applied to China’s State Food and Drug Administration (‘SFDA’) to vary the licence for importing Forceval into China.
There is uncertainty about whether or when this variation will be approved. There is a risk that for a period of time Unigreg will be
unable to import further product into China. There are a number of measures to mitigate this risk. The Board’s view is that these
mitigation measures are likely to be sufficient to ensure the continuation of the business in the long term, and that the intangible
asset relating to Forceval in China is unlikely to be impaired. 

A generic substitution and reference pricing regime is in the process of being implemented in the Republic of Ireland by the Health
Products Regulatory Authority (‘HPRA’). In 2014 the HPRA proposed that Nu-Seals be included on a list of interchangeable medicines.
The Company has made representations to the HPRA explaining why Nu-Seals should not be included on this list. The Board’s view is
that it is more likely than not that Nu-Seals will not be included on the list of interchangeable medicines and therefore the intangible
is unlikely to be impaired.

Business combinations
Management uses valuation techniques when determining the fair values of certain assets and liabilities acquired in a business
combination (see Note 35). In particular, the fair value of contingent consideration is dependent on the outcome of many variables
including the acquirees’ future sales (see Note 21).

2.4 Revenue recognition

Revenue comprises the fair value of the consideration received or receivable for the sale of goods in the ordinary course of the Group’s
activities. Revenue is shown net of value-added tax, estimated returns, rebates and discounts and after eliminating sales within the
Group and represents amounts invoiced to third parties in relation to the Group’s sole principle activity, namely the distribution of
pharmaceutical products. Revenue is recognised at the point when substantially all of the risks and rewards of ownership are
transferred to the customer; for UK customers normally this is when the goods are accepted at the customer’s specified delivery
address, and for international customers this is normally on dispatch. 

2.5 Foreign currency transactions

The consolidated financial statements are presented in Sterling, which is the presentational currency of the Group and the functional
currency of the Parent Company. Foreign currency transactions by Group companies are booked at the exchange rate ruling on the
date of the transaction. Foreign currency monetary assets and liabilities are retranslated into local currency at the rate of exchange
ruling at the balance sheet date. Differences on exchange resulting from the translation of overseas assets and liabilities are
recognised directly in equity. Gains and losses arising on currency borrowings used to hedge the foreign currency exposure on the net
assets of the foreign operations are accounted for directly in equity, to the extent that hedge accounting criteria are met and are
included in the consolidated statement of comprehensive income and expense.

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36 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

2. Summary of significant accounting policies continued

2.6 Property, plant and equipment

Computer equipment, fixtures, fittings and equipment are stated at the cost of purchase less any provisions for depreciation and
impairment. The rates generally applicable are:

Computer equipment 

20% - 33.3% per annum, straight line

Fixtures, fittings and equipment 

20% - 25% per annum, straight line

Material residual value estimates are updated as required, but at least annually, whether or not the asset is revalued.

2.7 Leases

Leasing agreements which transfer to the Group substantially all the benefits and risks of ownership are treated as finance leases, as
if the asset had been purchased outright. The assets are included within computer equipment, fixtures, fittings and equipment and the
capital element of the leasing commitments are shown as obligations under finance leases. Assets held under finance leases are
depreciated on a basis consistent with similar owned assets or the lease term if shorter. The interest element of the lease rental is
included in the income statement. All other leases are considered operating leases and the annual rentals are included in the income
statement on a straight line basis over the lease term.

2.8 Goodwill

Goodwill represents the excess of the consideration transferred over the fair value of the Group's share of the identifiable net assets
acquired. Goodwill is reviewed for impairment at least annually by assessing the recoverable amount of each acquisition, considered
to be a cash-generating unit, to which the goodwill relates. The recoverable amount is the higher of fair value less costs to sell and
value in use. When the recoverable amount of the cash-generating unit is less than the carrying amount an impairment loss is
recognised. Any impairment is recognised immediately in the Group Income Statement and is not subsequently reversed. 

2.9 Intangible assets

Acquired intangible assets

Intangible assets are stated at the lower of cost less provision for amortisation and impairment or the recoverable amount (explained
further in note 11). Technical know-how and trademarks are deemed to have an indefinite useful life and are tested for impairment
annually. Distribution licences are amortised over the current life of the licence on a straight line basis and are tested for impairment
annually. If the licence period can be extended, the useful life of the intangible asset shall include the renewal period only if there is
evidence to support renewal by the entity without disproportionate cost. In determining the useful economic life of distribution rights
each acquisition has been reviewed separately and consideration given to the period over which the Group expects to derive economic
benefit.

Internally-generated intangible assets - Research and development expenditure
Research expenditure is charged to the Income Statement in the period in which it is incurred. Development expenditure is capitalised
when it can be reliably measured and the project it is attributable to is separately identifiable, is technically feasible, demonstrates
future economic benefit, and will be used or sold by the Group once completed. 

The capitalised cost is amortised over the period during which the Group is expected to benefit and begins when the asset is ready 
for use. 

Development costs are reviewed at least annually for impairment by assessing the recoverable amount of each cash-generating unit,
to which the development costs relate. The recoverable amount is the higher of fair value less costs to sell and value in use. When the
recoverable amount of the cash-generating unit is less than the carrying amount an impairment loss is recognised. Any impairment is
recognised immediately in the Group Income Statement. Any reversal of a previously recorded impairment loss in a subsequent period
would also be recognised immediately in the Group Income Statement. 

Development costs not meeting the recognition criteria are expensed as incurred.

Impairment
For the purposes of assessing impairment, assets are grouped at the lowest levels for which there are separately identifiable cash
flows (cash-generating units). As a result, some assets are tested individually for impairment and some are tested at cash-generating
unit level. Goodwill, other individual assets or cash-generating units that include goodwill, other intangible assets with an indefinite
useful life, and those intangible assets not yet available for use are tested for impairment at least annually.

An impairment loss is recognised for the amount by which the asset's or cash-generating unit's carrying amount exceeds its
recoverable amount. The recoverable amount is the higher of fair value, reflecting market conditions less costs to sell, and value in
use based on an internal discounted cash flow evaluation. Impairment losses recognised for cash-generating units, to which goodwill
has been allocated, are credited initially to the carrying amount of goodwill. Any remaining impairment loss is charged pro rata to the
other assets in the cash-generating unit. With the exception of goodwill and development costs, all assets are subsequently
reassessed for indications that an impairment loss previously recognised may no longer exist.

Alliance Pharma plc | Annual Report 2015 37

2. Summary of significant accounting policies continued

2.10 Inventories

Inventories are included at the lower of cost less any provision for impairment or net realisable value. Cost is determined on a first-in-
first-out basis using the weighted average cost.

2.11 Taxation

The tax expense represents the sum of the tax currently payable and deferred tax.

The tax currently payable is based on the taxable profit for the year. Taxable profit differs from profit reported in the income statement
because the former excludes items of income or expense that are either taxable or deductible in other years or that are never taxable
or deductible, and it includes tax reliefs that are not included in the income statement. The Group’s liability for current tax is
calculated using tax rates that have been enacted or substantively enacted by the balance sheet date.

Deferred tax is the tax expected to be payable or recoverable on differences between the carrying amount of assets and liabilities in
the financial statements and the corresponding tax bases used in the computation of taxable profit, and is accounted for using the
balance sheet liability method. Deferred tax liabilities are provided in full on temporary differences, and deferred tax assets are
recognised to the extent that it is probable that future taxable profits will be available against which the temporary differences can be
utilised. Deferred tax is provided using the rates of tax that are expected to apply in the period when the liability is settled or the asset
is realised, based on rates that have been substantively enacted by the balance sheet date. Deferred tax assets and liabilities are not
discounted. The Group jointly controls the sharing of profits in the Joint Venture and as such no deferred tax has been recognised on
temporary differences.

2.12 Derivative financial instruments and hedging activities

Derivative financial instruments are used to manage exposure to market risk from treasury operations. The principal financial
instrument used by the Group is interest rate swaps. The Group does not hold or issue derivative financial instruments for trading or
speculative purposes. Derivative financial instruments are recognised in the balance sheet at fair value and then re-measured at
subsequent reporting dates. The fair value is calculated by reference to market interest rates and supported by counterparty
confirmation.

The interest rate swaps are designated as cash flow hedges.

The effective portion of changes in the fair value of derivative financial instruments that are designated as cash flow hedges is
recognised in other comprehensive income, while the gain or loss relating to the ineffective portion is recognised immediately in the
income statement. Changes in the fair value of derivative financial instruments that are not designated as cash flow hedges are
recognised in the income statement as they arise.

Exchange differences arising from the translation of the net investment in foreign operations are recognised directly in equity. Gains
and losses on those hedging instruments designated as hedges of the net investment in foreign operations, are recognised in equity to
the extent that the hedging relationship is effective; these amounts are included in exchange differences on translation of foreign
operations as stated in the statement of comprehensive income. Gains and losses relating to hedge ineffectiveness are recognised
immediately in the income statement for the period. Gains and losses accumulated in the translation reserve are included in the
income statement when the foreign investment is disposed of.

2.13 Debt instruments

Debt instruments are initially stated at their fair value net of issue costs, and subsequently measured at amortised cost using the
effective interest rate method.

2.14 Trade payables

Trade payables are recognised initially at fair value and subsequently measured at amortised cost using the effective interest rate
method.

2.15 Financial assets – loans and receivables

Loans and receivables are non-derivative financial assets with fixed or determinable payments that are not quoted in an active market.
They are included in current assets, except for maturities greater than 12 months after the balance sheet date. These are classified as
non-current assets. The Group’s loans and receivables comprise ‘trade and other receivables’ and ‘cash and cash equivalents’ in the
balance sheet (notes 2.16 and 2.17).

2.16 Trade receivables

Trade receivables are recognised initially at fair value and subsequently measured at amortised cost using the effective interest
method, less provision for impairment. A provision for impairment of trade receivables is established when there is objective evidence
that the Group will not be able to collect amounts due according to the original terms of the receivables.

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38 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

2. Summary of significant accounting policies continued

2.17 Cash and cash equivalents

For the purpose of the cash flow statement, cash and cash equivalents comprise cash on hand, deposits held at call with banks, other
short-term highly liquid investments, available with no penalty, with original maturities of three months or less, bank overdrafts and
working capital facilities.

2.19 Employee benefits - share-based compensation

The Group operates an equity-settled, share-based compensation plan. The fair value of the employee services received in exchange
for the grant of the options is recognised as an expense over the vesting period. The total amount to be expensed over the vesting
period is determined by reference to the fair value of the options granted. Non-market vesting conditions are included in assumptions
about the number of options that are expected to become exercisable. At each balance sheet date, the Group revises its estimates of
the number of options that are expected to become exercisable. It recognises the impact of the revision of original estimates, if any, in
the Group Income Statement, with a corresponding adjustment to equity. The proceeds received net of any directly attributable
transaction costs are credited to share capital (nominal value) and share premium when the options are exercised.

2.20 Equity

Equity comprises the following:

“Share capital” represents the nominal value of equity shares.

“Share premium” represents the excess over nominal value of the fair value of consideration received for equity shares, net of
expenses of the share issue.

“Share option reserve” represents equity-settled share-based employee remuneration until such share options are exercised.

“Reverse takeover reserve” represents the difference between the fair value and nominal value of shares issued on a reverse takeover.

“Other reserves” represents the fair value of derivative financial instruments at the balance sheet date that are designated as cash
flow hedges net of deferred tax, less amounts reclassified through other comprehensive income.

“Translation reserve” represents gains and losses arising on the net assets of overseas operations into Sterling.

“Retained earnings” represents retained profit.

2.21 Investments

Investments in subsidiaries included in the Company’s balance sheet are stated at cost less any provision for impairment.

2.22 Provisions

Provisions are recognised when there is a present legal or constructive obligation as a result of a past event, for which it is probable
that a transfer of economic benefits will be required to settle the obligation and where a reliable estimate can be made of the amount
of the obligation.

Where material, the provisions have been discounted to their present value.

2.23 Business combinations

Business combinations are accounted for using the acquisition accounting method. Identifiable assets, liabilities and contingent
liabilities acquired are measured at fair value at acquisition date. Any contingent consideration to be transferred by the acquirer will
be recognised at fair value at the acquisition date. Subsequent changes to the fair value of the contingent consideration which is
deemed to be an asset or liability will be recognised in accordance with IAS 39 either in profit or loss or as a change to other
comprehensive income.

2.24 Non-underlying items

Non-underlying items are those significant items which the Directors consider are not related to the normal trading activities of the
Group and are therefore separately disclosed to enable full understanding of the Group’s financial performance (see note 5). One-off
items relating to acquisitions e.g. acquisition costs and the costs of restructuring post-acquisition are shown as non-underlying.
Exceptional items including settlements and impairments of intangible assets are also shown as non-underlying items.

2.25 New standards not yet applied

A number of new EU adopted standards, amendments to standards and interpretations are not yet effective for the year ended 31
December 2015 and have not been applied in preparing these financial statements. The following list is not comprehensive but
includes the most significant to these financial statements:

l    IFRS 9 ‘Financial Instruments’ (2014), representing the completion of the IASB project to replace IAS 39 ‘Financial Instruments:
Recognition and Measurement’. The new standard introduces extensive changes to IAS 39’s guidance on the classification and
measurement of financial assets and introduces a new ‘expected credit loss’ model for the impairment of financial assets. IFRS 9
also provides new guidance on the application of hedge accounting. The new standard is required to be applied for annual reporting
periods beginning on or after 1 January 2018.

Alliance Pharma plc | Annual Report 2015 39

2. Summary of significant accounting policies continued

l    IFRS 15 ‘Revenue from Contracts with Customers’ replaces IAS 18 ‘Revenue’, IAS 11 ‘Construction Contracts’, and several revenue-
related interpretations. The new standard establishes a control-based revenue recognition model and provides additional guidance
in many areas not covered in detail under existing IFRSs, including how to account for arrangements with multiple performance
obligations, variable pricing, customer refund rights, supplier repurchase options, and other common complexities.

l    IFRS 16 ‘Leases’ replaces IAS 17 ‘Leases’. The new standard requires lessees to recognise a lease liability reflecting future lease
payments and a ‘right-of-use’ asset for virtually all lease contracts, excluding certain short-term leases and leases of low-value
assets. The new standard is required to be applied for annual reporting periods beginning on or after 1 January 2019.

The Group are currently assessing the impact of the new standards on the financial position or consolidated results of the Group.

The Group continually reviews amendments to the standards made under the IASB’s annual improvements project.

3. Segmental reporting

Operating segments

An operating segment is defined as a component of the entity: 

i)   that engages in business activities from which it may earn revenues and incur expenses;

ii)  whose operating results are regularly reviewed by the entity’s Chief Operating Decision Maker (‘CODM’) to make decisions about

the resources to be allocated to the segment and assess its performance; and

iii) for which discrete financial information is available.

For the year ended 31 December 2015 the Executive Team has been identified as the CODM.

Our management information system produces reports for the Executive Team grouping financial performance under the following
business areas:

l    Hydromol 
l    Secondary Care
l    Community and Consumer Products
l    Established Products 
l    International
All business areas are responsible for developing, marketing and distributing a range of pharmaceutical and other medical products.
As permitted by IFRS 8, since these business areas are deemed to have similar economic characteristics and are similar, if not the
same, in all of the following:

l    business areas derive their revenue from the supply of pharmaceutical products;
l    the production and distribution process is the same across all business areas;
l    business areas supply to similar customers i.e. pharmaceutical distributors or pharmacies; and
l    all business areas are subject to a similar regulatory environment.
The business areas have been aggregated into a single reportable segment, namely pharmaceuticals. Each month the CODM is
presented with financial information prepared in accordance with IFRS as adopted in the EU and the accounting policies set out in
note 2 to these financial statements. As such the financial information provided to the CODM regarding the operating segment has
already been disclosed in the financial statements.

Geographical information

The following revenue information is based on the geographical location of the customer:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

United Kingdom                                                                                                                                                                             39,444                     36,166
Ireland                                                                                                                                                                                               3,240                        3,116
Rest of the World                                                                                                                                                                             5,660                        4,254

Statutory revenue                                                                                                                                                                          48,344                     43,536
China Joint Ventures                                                                                                                                                                       1,325                        1,941

Total revenue                                                                                                                                                                                  49,669                     45,477

Non-current assets are located within the United Kingdom, France, Italy and the United States of America.

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40 Alliance Pharma plc | Annual Report 2015        

Notes to the Financial Statements continued
for year ended 31 December 2015

3. Segmental reporting continued

Major customers

During the year there were 2 (year ended 31 December 2014: 2) customers who separately comprised 10% or more of revenue.

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Major customer 1                                                                                                                                                                          13,470                     15,133
Major customer 2                                                                                                                                                                          10,420                     10,577

                                                                                                                                                                                                        23,890                     25,710

4. Profit before taxation
Profit before taxation is stated after charging/(crediting):

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Fees payable to the Company’s auditor for the audit of the Company’s annual accounts                                                           63                               8
Fees payable by the Group to the Company’s auditor for other services:                                                                                                                           
- The audit of the accounts of any associate of the Company                                                                                                        50                             44
- Audit-related assurance services                                                                                                                                                      9                               1
- All other taxation advisory services                                                                                                                                                 67                               -
- All services relating to corporate finance transactions (either proposed or entered into) by or on behalf                                 

of the Company or any of its associates                                                                                                                                       356                             32
Amortisation of intangible assets                                                                                                                                                     199                           488
Impairment of intangible assets                                                                                                                                                            -                           622
Share options charge                                                                                                                                                                         615                           571
Depreciation of plant, property and equipment                                                                                                                               239                           307
Operating lease rentals                                                                                                                                                                      100                             97
Research and development                                                                                                                                                                 12                               -
Profit on foreign exchange transactions                                                                                                                                          (52)                          (28)

5. Non-underlying and exceptional items
The non-underlying and exceptional items relate to the following:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

a)   Acquisition costs                                                                                                                                                                        1,846                               -
b)  Exceptional item                                                                                                                                                                      (6,332)                               -
c)   Notional interest                                                                                                                                                                            477                               -
d)  Charge in respect of loan settlement                                                                                                                                         273                               -
e)   Impairment of intangible fixed assets                                                                                                                                             -                           622

                                                                                                                                                                                                        (3,736)                           622

a)  The acquisition costs related to the acquisition of the Healthcare Products Business from Sinclair IS Pharma plc in December 2015

and amounted to £1.8m. The main costs included legal and professional fees of £1.2m and staffing costs of £0.5m.

b)  The exceptional item related to £6.7m compensation received from Sanofi Pasteur, net of £0.4m associated costs, for the

suspension of ImmuCyst production.

c)  Notional interest related to the unwinding of the discount on the deferred consideration payable for the acquisition of the share

capital of MacuVision Europe Limited.

Alliance Pharma plc | Annual Report 2015 41

5. Non-underlying and exceptional items continued
d)  The charge in respect of the loan settlement related to the release of £0.3m prepaid loan issue costs on the £18m loan repaid on 17

December 2015.

e)  The impairment of intangible fixed assets related to the write down of Pavacol-D Syrup, originally purchased for £0.6m, to £nil, to

reflect the uncertainty in being able to bring this product back into supply. 

6. Finance costs

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Interest payable and similar charges                                                                                                                                                                                      
     On loans and overdrafts                                                                                                                                                          (1,116)                        (968)
     Amortised finance issue costs                                                                                                                                                  (378)                        (104)
     Notional interest                                                                                                                                                                         (477)                          (18)

                                                                                                                                                                                                        (1,971)                     (1,090)

Interest income                                                                                                                                                                                   139                             48

Other finance income                                                                                                                                                                                                                
     Foreign exchange movements on cash balances                                                                                                                        52                             28

                                                                                                                                                                                                                52                             28

Finance costs – net                                                                                                                                                                       (1,780)                     (1,014)

Notional interest relates to the unwinding of the deferred consideration on the MacuVision acquisition. The notional interest in 2014 was the
discount applied to provisions (see note 24).

7. Directors and employees
Employee benefit expenses for the Group during the period were as follows:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                           Note                      £000s                      £000s  

Wages and salaries                                                                                                                                                                         6,604                        4,541
Social security costs                                                                                                                                                                           819                           556
Other pension costs                                                                                                                                             30                          362                           327
Share-based employee remuneration                                                                                                               26                          615                           571

                                                                                                                                                                                                          8,400                        5,995

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The average number of employees of the Group during the period was:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  

Management and administration                                                                                                                                                        86                             74

 
42 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

7. Directors and employees continued
Remuneration in respect of Directors (including pension) was as follows:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Emoluments                                                                                                                                                                                     1,657                           948

                                                                                                                                                                                                          1,657                           948

Gain on share options recognised by Directors during the year was £13,968 (2014: £nil).

For additional disclosures please refer to the Directors’ Remuneration section included in the Directors’ Report.

The amounts set out above include remuneration in respect of the highest-paid Director as follows:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Emoluments for qualifying services                                                                                                                                                 628                           226

During the period contributions were paid to defined contribution schemes for four Directors (year ended 31 December 2014: four).

Key management of the Group are the Executive Team. Benefit expenses in respect of the key management was as follows:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Short-term employee benefits                                                                                                                                                       1,566                           852

Share-based payments                                                                                                                                                                        69                           125

Post-employment benefits                                                                                                                                                                  35                             42

                                                                                                                                                                                                          1,670                        1,019

Average number of members of the CODM (the Executive Team) for the year ended 31 December 2015 was four (year ended 31 December
2014: four).

8. Taxation
Analysis of charge in period.

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

United Kingdom corporation tax at 20.25% (2014: 21.5%)                                                                                                                                                    
     In respect of current period                                                                                                                                                      2,977                        1,870
     Adjustment in respect of prior periods                                                                                                                                            -                          (38)

                                                                                                                                                                                                          2,977                        1,832
Deferred tax (see note 23)                                                                                                                                                                                                         
     Origination and reversal of temporary differences                                                                                                                 (398)                          (60)
     Adjustment in respect of prior periods                                                                                                                                      (89)                               -

Taxation                                                                                                                                                                                             2,490                        1,772

Alliance Pharma plc | Annual Report 2015 43

8. Taxation continued
The difference between the total current tax shown above and the amount calculated by applying the standard rate of UK corporation
tax to the profit before tax is as follows:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Profit on ordinary activities before tax                                                                                                                                        15,182                     10,157

Profit on ordinary activities multiplied by standard rate of corporation tax in the United Kingdom 
of 20.25% (2014: 21.5%)                                                                                                                                                                  3,074                        2,183
Effect of:                                                                                                                                                                                                                                      
Non-deductible expenses                                                                                                                                                                  429                           182
Attributable to Joint Venture                                                                                                                                                             (39)                          (69)
Adjustment in respect of prior period                                                                                                                                              (89)                          (38)
Impact of reduction in UK tax rate on deferred tax liability                                                                                                         (827)                        (300)
Differing tax rates on overseas earnings                                                                                                                                           54                               -
Share options                                                                                                                                                                                    (175)                               -
Other differences                                                                                                                                                                                  63                        (186)

Total taxation                                                                                                                                                                                    2,490                        1,772

Changes to the UK corporation tax rates were announced in the Chancellor's Budget on 8 July 2015. These include reductions to the main rate
to reduce the rate to 19% from 1 April 2017 and to 18% from 1 April 2020. As the changes were substantively enacted at the balance sheet date
the effects are included in these financial statements (2014: 20%). 

A change to the UK corporation tax rate was announced in the Chancellor's Budget on 16 March 2016, reducing the main rate to 17% from 1
April 2020. As the change was not substantively enacted at the balance sheet date the effect is not included in these financial statements. The
overall effect of this change, if it had applied to the deferred tax balance at the balance sheet date, would be to reduce the deferred tax liability
by an additional £1,083,168 and decrease the tax expense for the period by £403,168. £680,000 of the movement relates to deferred tax
recognised on business combination and would have no impact to the tax expense.

9. Dividends

                                                                                                                                                               Year ended                                              Year ended
                                                                                                                                                            31 December                                          31 December
                                                                                                                                                                           2015                                                         2014
                                                                                                                            Pence/share                      £000s           Pence/share                      £000s

Amounts recognised as distributions to owners in the year:                                                                                                               
Interim dividend for the prior financial year                                                                0.333                             880                       0.303                           800
Final dividend for the prior financial year                                                                    0.667                         1,763                       0.605                        1,598

                                                                                                                                         1.000                         2,643                       0.908                        2,398

Interim dividend for the current financial year                                                           0.366                         1,714                       0.333                           880

The proposed final dividend of 0.734 pence per share for the current financial year was approved by the Board of Directors on 31 March 2016
and is subject to the approval of shareholders at the Annual General Meeting. The proposed dividend has not been included as a liability as at
31 December 2015 in accordance with IAS 10 Events After the Balance Sheet Date. The interim dividend for the current financial year was paid
on 14 January 2016. Subject to shareholder approval, the final dividend will be paid on 13 July 2016 to shareholders who are on the register of
members on 17 June 2016.

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44 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

10. Earnings per share (‘EPS’)
Basic EPS is calculated by dividing the earnings attributable to ordinary shareholders by the weighted average number of ordinary
shares in issue during the year. For diluted EPS, the weighted average number of ordinary shares in issue is adjusted to assume
conversion of all dilutive potential ordinary shares. 

A reconciliation of the weighted average number of ordinary shares used in the measures is given below:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014

For basic EPS calculation                                                                                                                                                   272,729,247            264,148,367
Employee share options                                                                                                                                                          6,322,550                1,454,986

For diluted EPS calculation                                                                                                                                                279,051,797            265,603,353

The adjusted basic EPS is intended to demonstrate recurring elements of the results of the Group before exceptional items. A reconciliation of
the earnings used in the different measures is given below:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Earnings for basic EPS                                                                                                                                                                 12,692                        8,385
Non-underlying: exceptional items                                                                                                                                             (6,332)                           622
Other non-underlying items                                                                                                                                                           2,596                               -
Tax effect of non-underlying items                                                                                                                                                1,115                        (124)

For adjusted EPS                                                                                                                                                                           10,071                        8,883

The resulting EPS measures are:

                                                                                                                                                                                                Year ended              Year ended  
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         Pence                      Pence  

Basic EPS                                                                                                                                                                                           4.65                          3.17

Diluted EPS                                                                                                                                                                                        4.55                          3.16

Adjusted basic EPS                                                                                                                                                                            3.69                          3.36

Adjusted diluted EPS                                                                                                                                                                         3.61                          3.34

Alliance Pharma plc | Annual Report 2015 45

11. Intangible assets

                                                                                                                                                       Technical know-                                                                 
                                                                                                                                                      how, trademarks                                                                 
                                                                                                                                                        and distribution          Development                                 
                                                                                                                                    Goodwill                       rights                        costs                        Total
The Group                                                                                                                       £000s                      £000s                      £000s                      £000s

Cost                                                                                                                                                                                                                                             
At 1 January 2015                                                                                                            3,593                     88,504                           431                     92,528
Additions                                                                                                                                  -                     16,925                               7                     16,932
Additions due to acquisition                                                                                         22,442                   130,565                               -                   153,007
Exchange adjustments                                                                                                          -                        1,330                               -                        1,330

At 31 December 2015                                                                                                  26,035                     237,324                             438                     263,797

Amortisation and impairment                                                                                                                                        
At 1 January 2015                                                                                                                   -                        3,653                               -                        3,653
Amortisation for the year                                                                                                       -                           199                               -                           199

At 31 December 2015                                                                                                            -                         3,852                                  -                         3,852

Net book amount                                                                                                                                                                                                                                     
At 31 December 2015                                                                                                  26,035                     233,472                             438                     259,945

At 1 January 2015                                                                                                            3,593                     84,851                           431                     88,875

Goodwill 

During the year ended 29 February 2004 goodwill of £1.1m arose on the acquisition of Dermapharm Ltd. 

During the year ended 31 December 2010, the Group completed the purchase of the trade and certain assets of Cambridge
Laboratories (Ireland) Limited and Cambridge Laboratories Limited. The goodwill of £0.6m that arose on acquisition reflects Alliance’s
entry into the oncology market with an established brand name and sales force. 

Goodwill of £1.9m arose on acquisition of Opus Group Holdings Limited in the year ended 31 December 2012.

Goodwill on consolidation of £20.7m arose on the acquisition of certain assets and businesses from Sinclair IS Pharma plc (see note
35). The fair values set out above are provisional figures which will be finalised in the 2016 financial statements following
management’s final review of key reconciliations and judgemental areas relating to acquired inventory and creditor balances. 

Additional goodwill of £1.7m arose on the acquisition of the share capital of MacuVision Europe Limited (see note 35).

Technical know-how, trademarks and distribution rights

Acquired technical know-how, trademarks and distribution rights when purchased are assessed to ensure they meet a set of criteria
including an established and stable sales history. The products are generally in niche areas where there is limited foreseeable
prospect of erosion of sales and they require little or no promotion to maintain sales. 

The following acquisition activities took place in the year:

l   On 2 February 2015, the Group completed the acquisition of MacuVision Europe Limited (‘MacuVision’) for initial consideration of
£5.5 million plus the net asset value of MacuVision at completion (£0.5m) and deferred contingent consideration of up to £6.0
million (estimated at £3.2m). MacuVision sells MacuShield, an eye care treatment designed to be taken by sufferers of dry age-
related macular degeneration and other eye conditions. The fair value of the intangible asset acquired was £8.8m included within
technical know-how, trademarks and distribution rights. 

l   On 29 January 2015, the Group entered a Licence and Supply Agreement for the product Diclectin with Duchesnay Inc. The
consideration recognised in relation to this is £1.5m. Diclectin is a product to treat nausea and vomiting of pregnancy and is
anticipated to launch in 2017. 

l   On 16 September 2015 the Company acquired the rights to five Nutraceutical brands from Sinopharm Nutraceuticals (Shanghai) Co
Ltd for an estimated total consideration of RMB 13.7m (£1.4m). Rujiali (Calcium), Lefuzhi (DHA capsules), Aiweidi (Vitamin D drops),
Manlun Junshe and Changmin (probiotic powder drink) are marketed in China. The consideration was payable in four instalments
including a final instalment payable based on 2016 sales. 

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46 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

11. Intangible assets continued
l   On 17 December 2015 Alliance Pharmaceuticals Limited completed the acquisition of certain assets and businesses from Sinclair
IS Pharma plc. The acquisition included 27 products including four key growth brands (Kelo-cote, Flammacerium, Aloclair, and
Atopiclair). The acquisition is effected as the purchase of the collection of companies forming the SPH Group and the acquisition of
the Product Aloclair not owned by those Companies and their related businesses. The SPH Group is a collection of four companies:
Advanced Bio-Technologies Inc. (incorporated in Florida, USA), Sinclair Pharma S.r.l. (incorporated in Italy), Sinclair Pharma
France SAS (incorporated in France) and Maelor Laboratories Limited (incorporated in England and Wales). The total consideration
for the acquisition was £127.5 million, plus £5.3 million for inventory, satisfied partly in cash, funded by way of new loans, and
partly by the issue and allotment of additional shares. The fair value of the intangible assets acquired was £135.8m.

Impairment

As explained in notes 2.8 and 2.9 all intangible assets are stated at the lower of cost less provision for amortisation and impairment or
the recoverable amount. 

Goodwill (allocated across cash-generating units that are expected to benefit from it), indefinite life assets and development costs are
tested for impairment annually, or more frequently if there are indications that amounts might be impaired. The impairment test
involves determining the recoverable amount of the relevant asset or cash-generating unit, which corresponds to the higher of the fair
value less costs to sell or its value in use.

The value in use calculation considers each asset or cash generating unit on a case by case basis and uses cash flow projections
based on financial forecasts for the next two years, which are based on historic sales trends and management’s sales growth
assumptions. These forecasts are approved by management and extrapolated for a 15 year period or the useful economic life,
whichever is the shorter.

The key assumptions on which cash flow projections are made are:

l    There will be no growth beyond 2017;

l   Cash flows are discounted at an appropriate rate. The discount rates consider market information and specific circumstances of

each asset or cash-generating unit. A rate of 10%, which approximates to the Group’s weighted average cost of capital, is
considered appropriate for all assets; and 

l   The CODM considers 15 years to be a sufficient period to represent the indefinite useful economic lives of the products. 

The value in use calculations for assets and cash-generating units, when tested with assumptions beyond a reasonable range, did not
result in the recoverable amounts falling below their carrying value.

Development projects are reviewed as to the likelihood of their completion and valued using a discounted cash flow, using appropriate
risk factors, to assess whether the project is impaired. 

A generic substitution and reference pricing regime is in the process of being implemented in the Republic of Ireland by the Health
Products Regulatory Authority (‘HPRA’). In 2014 the HPRA proposed that Nu-Seals be included on a list of interchangeable medicines.
The Company has made representations to the HPRA explaining why Nu-Seals should not be included on this list. The Board’s view is
that it is more likely than not that Nu-Seals will not be included on the list of interchangeable medicines and the related intangible
asset of £9.1m is not impaired. The recoverable amount, based on value in use, is estimated at £11.6m. The key assumptions in
arriving at the value in use are that the Nu-Seals’ volumes will fall by around 30% and that pricing will not change. The intangible
asset could be impaired if volumes fell by more than 50%, or if pricing fell by more than 22%. If Nu-Seals were to be included on the
list of interchangeable medicines, pricing may fall by 58%.

Alliance Pharma plc | Annual Report 2015 47

11. Intangible assets continued

                                                                                                                                                         Technical know                                                                 
                                                                                                                                                      how, trademarks                                                                 
                                                                                                                                                        and distribution          Development                                 
                                                                                                                                    Goodwill                       rights                        costs                        Total
The Group                                                                                                                       £000s                      £000s                      £000s                      £000s

Cost                                                                                                                                                                                                                                                            
At 1 January 2014                                                                                                            3,593                     85,687                           373                     89,653
Additions                                                                                                                                  -                        2,817                             58                        2,875

At 31 December 2014                                                                                                     3,593                     88,504                           431                     92,528

Amortisation and impairment                                                                                                                                                                                                             
At 1 January 2014                                                                                                                   -                        2,543                               -                        2,543
Amortisation for the year                                                                                                       -                           488                               -                           488
Impairment for the year                                                                                                         -                           622                               -                           622

At 31 December 2014                                                                                                             -                        3,653                               -                        3,653

Net book amount                                                                                                                                                                                                                                     
At 31 December 2014                                                                                                     3,593                     84,851                           431                     88,875

At 1 January 2014                                                                                                            3,593                     83,145                           373                     87,111

12. Property, plant and equipment 

                                                                                                                                                 Fixtures,                                                                                     
                                                                                                                  Computer         fittings and               Plant &                  Motor                            
                                                                                                                 equipment          equipment          machinery               vehicles                    Total
The Group                                                                                                       £000s                  £000s                  £000s                  £000s                  £000s

Cost                                                                                                                                                                                                                              
At 1 January 2015                                                                                               584                      995                           -                           -                   1,579
Additions                                                                                                              414                      223                           -                           -                      637
Additions due to acquisition                                                                                   -                      102                      109                          8                      219

At 31 December 2015                                                                                        998                     1,320                        109                             8                     2,435

Depreciation                                                                                                                                                                                                                               
At 1 January 2015                                                                                               322                      861                           -                           -                   1,183
Provided in the year                                                                                            116                      120                           -                          3                      239

At 31 December 2015                                                                                        438                        981                             -                             3                     1,422

Net book amount                                                                                                                                                                                                                       
At 31 December 2015                                                                                        560                        339                        109                             5                     1,013

At 1 January 2015                                                                                               262                      134                           -                           -                      396

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48 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

12. Property, plant and equipment continued

                                                                                                                                                 Fixtures,                                                                                     
                                                                                                                  Computer         fittings and               Plant &                  Motor                            
                                                                                                                 equipment          equipment          machinery               vehicles                    Total
The Group                                                                                                       £000s                  £000s                  £000s                  £000s                  £000s

Cost                                                                                                                                                                                                                              
At 1 January 2014                                                                                               479                      989                           -                           -                   1,468
Additions                                                                                                              105                          6                           -                           -                      111

At 31 December 2014                                                                                         584                      995                           -                           -                   1,579

Depreciation                                                                                                                                                                                                  
At 1 January 2014                                                                                               211                      665                           -                           -                      876
Provided in the year                                                                                            111                      196                           -                           -                      307

At 31 December 2014                                                                                         322                      861                           -                           -                   1,183

Net book amount                                                                                                                                                                                           
At 31 December 2014                                                                                         262                      134                           -                           -                      396

At 1 January 2014                                                                                               268                      324                           -                           -                      592

13. Investments

                                                                                                                                                                                                          Investment in subsidiary  
                                                                                                                                                                                                                              undertakings
The Company                                                                                                                                                                                                                   £000s  

Cost
At 1 January 2015                                                                                                                                                                                                           51,936
Additions                                                                                                                                                                                                                          86,633

At 31 December 2015                                                                                                                                                                                                  138,569

At 1 January 2014                                                                                                                                                                                                           47,119
Additions                                                                                                                                                                                                                            4,817

At 31 December 2014                                                                                                                                                                                                     51,936

The additions in the year relate to the increased investment the Company has made in Alliance Pharmaceuticals Limited and Alliance
Pharmaceuticals SAS to support the acquisition of new business and product licences. 

Alliance Pharma plc | Annual Report 2015 49

13. Investments continued
The subsidiary and associated undertakings where the Group held 20% or more of the equity share capital at 31 December 2015 are
shown below:

Company                                                                     Country of registration    Shares held                      %                             Nature of
                                                                                     or incorporation               Class                                 owned                     business

Alliance Pharmaceuticals Limited                           United Kingdom               Ordinary                            100                           Pharmaceutical sales
Dermapharm Limited                                               United Kingdom               Ordinary                            100                           Dormant 
Alliance Health Limited                                             United Kingdom               Ordinary                            100                           Dormant
Alliance Consumer Health Limited                         United Kingdom               Ordinary                            100                           Dormant
Alliance Generics Limited                                         United Kingdom               Ordinary                            100                           Dormant
Alliance Healthcare Limited                                     United Kingdom               Ordinary                            100                           Dormant
Caraderm Limited                                                     Northern Ireland             Ordinary                            100                           Dormant
Unigreg Limited                                                         British Virgin Islands       Ordinary                            60                             Pharmaceutical sales
Unigreg Worldwide Limited                                      United Kingdom               Ordinary                            60                             Dormant
Opus Group Holdings Limited                                  United Kingdom               Ordinary                            100                           Dormant
Opus Healthcare Limited                                          United Kingdom               Ordinary                            100                           Dormant
Opus Healthcare Limited                                          Republic of Ireland          Ordinary                            100                           Non-trading
Alliance Pharmaceuticals GmbH                             Germany                           Ordinary                            100                           Non-trading
Alliance Pharmaceuticals SAS                                 France                               Ordinary                            100                           Non-trading
Synthasia International Company Limited              Hong Kong                       Ordinary                            20                             Pharmaceutical sales
Synthasia Shanghai Co. Limited                              China                                 Ordinary                            20                             Pharmaceutical sales
Alliance Pharmaceuticals (Asia) Limited                Hong Kong                       Ordinary                            100                           Pharmaceutical sales
Alliance Pharmaceuticals Shanghai Limited         China                                 Ordinary                            100                           Pharmaceutical sales
MacuVision Europe Limited                                      United Kingdom               Ordinary                            100                           Pharmaceutical sales
Maelor Laboratories Limited                                    United Kingdom               Ordinary                            100                           Pharmaceutical sales
Sinclair Pharma S.r.l.                                                Italy                                   Ordinary                            100                           Pharmaceutical sales
Advanced Bio-Technologies Inc.                              USA                                   Ordinary                            100                           Pharmaceutical sales
Sinclair Pharma France SAS                                    France                               Ordinary                            100                           Pharmaceutical sales

All subsidiary undertakings prepare accounts to 31 December, except Opus Healthcare Limited (Republic of Ireland) which prepares
accounts to 28 February, Unigreg Worldwide Limited which prepares accounts to 31 May and Sinclair Pharma S.r.l. which prepares
accounts to 30 June. Alliance Pharmaceuticals Limited, Alliance Pharmaceuticals GmbH, Alliance Pharmaceuticals SAS and Alliance
Pharmaceutical (Asia) Limited are the only investments held directly by Alliance Pharma plc. All other investments are held by
Alliance Pharmaceuticals Limited with the exception of Opus subsidiaries which are held by Opus Group Holdings Limited, Unigreg
Worldwide Limited which is held by Unigreg Limited, Synthasia Shanghai Co. Ltd which is held by Synthasia International Company
Ltd, Alliance Pharmaceuticals Shanghai Limited which is held by Alliance Pharmaceuticals (Asia) Limited, and Sinclair Pharma
France SAS which is held by Alliance Pharmaceuticals SAS.

14. Inventories

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
The Group                                                                                                                                                                                       £000s                      £000s  

Finished goods and materials                                                                                                                                                      13,376                        6,742  
Inventory provision                                                                                                                                                                           (466)                        (828)  

                                                                                                                                                                                                        12,910                        5,914  

Inventory costs expensed through the income statement during the year were £15,693,000 (2014: £15,964,000). During the year £264,665 (2014:
£61,774) was recognised as an expense relating to the write-down of stock to net realisable value.

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50 Alliance Pharma plc | Annual Report 2015        

Notes to the Financial Statements continued
for year ended 31 December 2015

15. Trade and other receivables

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                                                    £000s                  £000s                  £000s                  £000s

Trade receivables                                                                                                                        8,783                   6,645                           -                           -
Other receivables                                                                                                                         1062                      669                        16                        17
Prepayments and accrued income                                                                                               525                      453                        10                          8
Amounts owed by Joint Venture                                                                                                   1,260                      555                           -                           -

                                                                                                                                                     11,630                   8,322                        26                        25

The ageing of trade receivables at 31 December is detailed below:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Not past due                                                                                                                                                                                     5,965                        4,105
Due 30-31 December                                                                                                                                                                      1,403                        1,415
Past due 3 days to 91 days                                                                                                                                                              1,228                           964
Past 91 days                                                                                                                                                                                         187                           161

                                                                                                                                                                                                          8,783                        6,645

For the year ended 31 December 2015 £578,000 was received by 8 January 2016. For the year ended 31 December 2014 £1,545,000 was
received by 9 January 2015. 

Trade and other receivables are stated net of estimated allowances for doubtful debts. As at 31 December 2015, trade and other receivables of
£nil (for the year ended 31 December 2014: £nil) were past due and impaired.

Our policy requires customers to pay us in accordance with agreed payment terms. Depending on the geographical location, our settlement
terms are generally due within 30 or 60 days from the end of the month of sale and do not bear any effective interest rate. 

16. Cash and cash equivalents

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                                                    £000s                  £000s                  £000s                  £000s

Cash at bank and in hand                                                                                                           3,229                   1,434                           -                        12
Working capital facility                                                                                                                  (31)                      (414)                     (30)                           -

                                                                                                                                                      3,198                   1,020                     (30)                        12

17. Major non-cash transactions
Principal non-cash transactions include finance issue costs amortised and written off in the income statement during the year of
£378,000 (2014: £104,000) and an exchange movement of £52,000 (2014: £28,000) (see note 6). Interest rate swaps designated as cash
flow hedges resulted in a £9,000 gain (2014: £572,000 loss) to other comprehensive income. Amortisation of intangible assets resulted
in a total charge of £199,000 (2014: £488,000, impairment £622,000) being recognised in the income statement. During the year the
discount on the deferred consideration was recognised as a notional interest charge through the income statement for the amount of
£477,000 (2014: £nil) (see note 6). A notional interest charge, representing the unwinding of the discounted value of the onerous
contract provision of £18,000, was recognised in the income statement in 2014. Nothing was recognised during the year.

Alliance Pharma plc | Annual Report 2015 51

18. Trade and other payables - current

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                                                    £000s                  £000s                  £000s                  £000s

Trade payables                                                                                                                             1,153                   1,693                           -                           -
Other taxes and social security costs                                                                                          905                      969                           -                           -
Accruals and deferred income                                                                                                  5,663                   4,065                      571                      183
Other payables                                                                                                                                728                      193                           -                           -
Deferred consideration for acquisitions                                                                                   5,026                           -                           -                           -
Amounts due to Joint Ventures                                                                                                     398                           -                           -                           -

                                                                                                                                                    13,873                   6,920                      571                      183

Deferred consideration of £2.8m (year ended 31 December 2014: £nil) relates to the acquisition of MacuVision Europe Limited which took place
on 2 February 2015 and is payable in April 2016 (see note 35). Deferred consideration of £0.4m (year ended 31 December 2014: £nil) relates to
the acquisition of the rights to five Nutraceutical brands from Sinopharm Nutraceuticals (Shanghai) Co Ltd which took place on 16 September
2015 and is payable during 2016. Deferred consideration of £1.8m (year ended 31 December 2014: £nil) relates to the acquisition of certain
assets and businesses from Sinclair IS Pharma plc which took place on 17 December 2015. This is payable during 2016 (see note 35).

19. Financial liabilities - borrowings

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
Current                                                                                                                                       £000s                  £000s                  £000s                  £000s

Bank loans due within one year or on demand:                       
Secured                                                                                                                                      16,000                   3,000                           -                           -
Finance issue costs                                                                                                                     (224)                    (105)                           -                           -

                                                                                                                                                    15,776                   2,895                           -                           -

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
Non-current                                                                                                                                            £000s                    £000s                   £000s                    £000s

Bank loans:                                                                                                                                                                        
Secured                                                                                                                                      59,918                 19,500                           -                           -
Finance issue costs                                                                                                                     (950)                      (265)                           -                           -

                                                                                                                                                    58,968                 19,235                           -                           -

The Group has a total committed bank facility of £100m (31 December 2014: £46.3m) maturing in November 2020 of which £65m is drawn as
‘term loan and £35m is available to draw down through a Revolving Credit Facility (‘RCF’). The RCF is repayable within one to three months and
therefore included within current liabilities.

The bank facility is secured by a fixed and floating charge over the Company's and Group’s assets.

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52 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

20. Other non-current liabilities

                                                                                                                                                                                Group                                             Company
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                                                    £000s                  £000s                  £000s                  £000s

Deferred consideration for acquisitions                                                                                   1,383                           -                           -                           -
Other non-current liabilities                                                                                                         113                           -                           -                           -

                                                                                                                                                      1,496                           -                           -                           -

Deferred consideration of £0.9m (year ended 31 December 2014: £nil) relates to the acquisition of MacuVision Europe Limited which took place
on 2 February 2015 and is payable in April 2017 (see note 35). Deferred consideration of £0.5m (year ended 31 December 2014: £nil) relates to
the Licence and Supply Agreement for the product Diclectin with Duchesnay Inc. and is payable in May 2017. 

21. Financial instruments
The Group uses financial instruments comprising borrowings, some cash and liquid resources, and various items such as trade
receivables and trade payables that arise directly from its operations. The main risks arising from the Group’s financial instruments
are liquidity risk, interest rate risk and foreign currency risk. The Board reviews and agrees policies for managing each of these risks
and they are summarised below. These policies have remained unchanged from the previous year.

In addition to Sterling, the Group also has bank facilities denominated in Euros and US Dollars. The purpose of these facilities is to
manage the currency risk arising from the Group's operations. 

Liquidity Risk

The Group seeks to manage financial risk by ensuring at all times there is sufficient liquidity to meet its financial liabilities as they fall
due and to invest any surplus cash safely and profitably. The Group finances its operations through a mixture of debt and equity. The
Group’s main source of debt is provided by a £100m committed Credit Facility maturing in November 2020 (year ended 31 December
2014: £46.3m). This is made up of amortising Term Debt of £65m (year ended 31 December 2014: £20m) and a Revolving Credit Facility
(‘RCF’) of £35m (year ended 31 December 2014: £25m). In order to manage currency risk the Group has borrowed part of the Term
Loans in Euros and US Dollars as follows: EUR 18m (£13.2m) (year ended 31 December 2014: £nil) and USD 36m (£24.3m) (year ended
31 December 2014: £nil); the remainder is denominated in Sterling. At year end the Group had also drawn down £10m of the RCF
(year ended 31 December 2014: £1.3m). The Group also has access to an uncommitted overdraft facility of £4.5m.

The Group balance sheet also includes financial assets in the form of cash at bank and in hand totalling £3,229,000 (31 December
2014: £1,434,000). Of this £2,431,000 was held in Sterling, £759,000 in Euro and the balance in other currencies.

Interest rate risk

The Group’s debt is provided on a floating interest rate basis. The Group uses interest rate swaps to fix the rates paid on a portion of
its debt in order to mitigate against the risks of increasing interest rates. These swaps are re-measured to fair value at each period
end. The valuations are indicative values based on mid-market levels as at the close of business on the balance sheet date.

The Group has in place interest rate swaps with a nominal value of £20m (year ended 31 December 2014: £20m) to convert the floating
interest rate charge to a fixed rate interest charge maturing in April 2018.

Subsequent to year end the Group implemented the following interest rate swaps:

l   Euro interest rate swap: Nominal value EUR 18m, start date of 31 March 2016 amortising to maturity in November 2020.

l   Sterling interest rate swap: Nominal value of £16m, start date of 11 April 2018 amortising to maturity in November 2020.

Alliance Pharma plc | Annual Report 2015 53

21. Financial instruments continued
The interest rate exposure of the financial liabilities of the Group at the period end was:

                                                                                                                                                                          Fixed                    Floating                          Total  
                                                                                                                                                                                          £000s                        £000s                        £000s  

At 31 December 2015                                                                                                                                                                                                                              
Bank loans – Sterling denominated                                                                                                                      -                     38,359                     38,359
Bank loans – Euro denominated                                                                                                                           -                     13,235                     13,235
Bank loans – US Dollar denominated                                                                                                                  -                     24,324                     24,324
Interest rate hedges – Sterling denominated                                                                                             20,000                   (20,000)                               -

Sterling subtotal                                                                                                                                           20,000                       55,918                       75,918

Working capital facility                                                                                                                                           -                               -                               -

Total financial liabilities                                                                                                                              20,000                       55,918                       75,918

Unamortised issue costs                                                                                                                                        -                     (1,174)                     (1,174)

Net book value of financial liabilities                                                                                                        20,000                       54,744                       74,744

At 31 December 2014                                                                                                                                                                                                                             
Bank loans – Sterling denominated                                                                                                                      -                     22,500                     22,500
Interest rate hedges – Sterling denominated                                                                                             20,000                   (20,000)                               -

Sterling subtotal                                                                                                                                            20,000                        2,500                     22,500

Working capital facility                                                                                                                                           -                           414                           414

Total financial liabilities                                                                                                                                20,000                        2,914                     22,914

Unamortised issue costs                                                                                                                                        -                        (370)                        (370)

Net book value of financial liabilities                                                                                                          20,000                        2,544                     22,544

                                                                                                                                                                                                              Fixed rate financial liabilities
                                                                                                                                                                                                    Weighted                 Weighted
                                                                                                                                                                                                      average       average period 
                                                                                                                                                                                                fixed rate %                 for which 
                                                                                                                                                                                                                                 rate is fixed

At 31 December 2015                                                                                                                                                                                                                             
Sterling                                                                                                                                                                                                           2.94                2.27 years

At 31 December 2014                                                                                                                                                                                                                
Sterling                                                                                                                                                                                                3.19               3.27 years

The Sterling floating rate borrowings bear interest at a rate based on LIBOR. The Euro floating rate borrowings bear interest at a rate based on
EURIBOR. The US Dollar floating rate borrowings bear interest at a benchmark rate (US Dollar LIBOR).

A 0.5% increase in LIBOR would reduce pre-tax profits by approximately £213,000 in 2016. A 0.5% decrease would have the opposite effect.

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54 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

21. Financial instruments continued

Currency risk

Approximately 30% of the Group's sales are invoiced in Euros. The Group also has a level of Euro expense that naturally nets off a high
portion of the Euro sales. Approximately 10% of the Group’s sales are invoiced in US Dollar, a portion of which will be used to service
the US Dollar denominated debt. The majority of other Group sales, and all but a small proportion of other Group expenses, are
denominated in Sterling. 

A 5% weakening of Sterling against the Euro would result in a £47,000 decrease in predicted pre-tax profits, while a 5% strengthening
of Sterling would have the approximate opposite effect. A 5% weakening of Sterling against the US Dollar would result in a £439,000
increase in predicted pre-tax profits, while a 5% strengthening of Sterling would have the approximate opposite effect.

Net investment hedges

The Group uses currency denominated borrowings to hedge the exposure of a portion of its net investment in overseas operations
against changes in value due to changes in foreign exchange rates. The net investment hedge was tested for effectiveness during the
year and found to be highly effective. The ineffective element is immaterial. At 31 December 2015 the fair value of the hedge was US
Dollar 36.0m (£24.3m).

Fair value measurement

Effective from 1 January 2013, the Group adopted the amendments to IFRS13 for financial instruments that are measured in the
Group balance sheet at fair value. This requires disclosure of fair value measurements by level of the following fair value
measurement hierarchy:

l   quoted prices (unadjusted) in active markets for identical assets or liabilities (Level 1);

l   inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either directly (that is, as

prices) or indirectly (that is, derived from prices) (Level 2); and

l   inputs for the asset or liability that are not based on observable market data (that is, unobservable inputs) (Level 3).

Lloyds Bank perform valuations of financial items for financial reporting purposes. Valuation techniques are selected based on the
characteristics of each instrument, with the overall objective of maximising the use of market-base information. Valuation processes
and fair value changes are discussed among the Audit Committee and the finance team at least every year, in line with the Group's
reporting dates.

The valuation techniques used for instruments categorised in Levels 2 and 3 are described below:

Interest rate swaps (Level 2)

The Group's interest rate swaps are not traded in active markets. These have been fair valued using observable interest rates. The
effects of non-observable inputs are not significant for interest rate swaps. 

The following table presents the Group’s financial liabilities that are measured at fair value at 31 December 2015:

                                                                                                                                                   Level 1                Level 2                Level 3                    Total  
Liabilities                                                                                                                                    £000s                  £000s                  £000s                  £000s

Derivative financial instruments:                                                                                                                                    
     Interest rate swaps                                                                                                                        -                        120                             -                        120

                                                                                                                                                              -                        120                             -                        120

Alliance Pharma plc | Annual Report 2015 55

21. Financial instruments continued
The following table presents the Group’s financial liabilities that are measured at fair value at 31 December 2014:

                                                                                                                                                   Level 1                Level 2                Level 3                    Total  
Liabilities                                                                                                                                    £000s                  £000s                  £000s                  £000s

Derivative financial instruments:                                                                                                                                    
     Interest rate swaps                                                                                                                        -                      129                           -                      129

                                                                                                                                                              -                      129                           -                      129

The maturity profile of the Group's bank loans (capital only) at the year end is as follows:

                                                                                                                                                                                        At 31 December     At 31 December 
                                                                                                                                                                                                           2015                         2014  
                                                                                                                                                                                                         £000s                      £000s  

Due within:                                                                                                                                                                                                 
One year                                                                                                                                                                                          16,000                        3,000
More than one year, not more than two years                                                                                                                             8,000                        3,000
More than two years, not more than three years                                                                                                                         8,000                        3,000
More than three years                                                                                                                                                                   43,918                     13,500

                                                                                                                                                                                                        75,918                     22,500

The maturity profile of the Group's financial gross liabilities (capital and interest) at the year-end is as follows:

                                                                                                                                                                 31 December 2015
                                                                                                                                                       In more than      In more than
                                                                                                                                                              one year,           two years,
                                                                                                                          In one year,      but not more      but not more      In more than                               
                                                                                                                                   or less              than two              than five            five years                     Total
                                                                                                                                     £000s                   £000s                   £000s                   £000s                   £000s

Trade and other payables                                                                            13,873                     1,496                             -                             -                  15,369
Working capital facility                                                                                         31                             -                             -                             -                           31
Bank loans                                                                                                     17,946                     9,658                  55,310                             -                  82,914

                                                                                                                       31,850                  11,154                  55,310                             -                  98,314  

                                                                                                                                                                 31 December 2014
                                                                                                                                         In more than      In more than
                                                                                                                                                one year,           two years,
                                                                                                               In one year,      but not more      but not more      In more than                            
                                                                                                                        or less             than two              than five            five years                    Total
                                                                                                                         £000s                  £000s                  £000s                  £000s                  £000s

Trade and other payables                                                                               6,920                           -                           -                           -                   6,920
Working capital facility                                                                                       414                           -                           -                           -                      414
Bank loans                                                                                                       3,642                   3,548                 16,950                           -                 24,140
Onerous contracts                                                                                              227                           -                           -                           -                      227

                                                                                                                        11,203                  3, 548                 16,950                           -                 31,701

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56 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

21. Financial instruments continued
The maturity profile of the Company's financial gross liabilities (capital and interest) at the year end is as follows:

                                                                                                                                                              31 December 2015                           31 December 2014
                                                                                                                                                                                   Bank                                                Bank
                                                                                                                                                     Trade        borrowings                   Trade         borrowings
                                                                                                                                               payables                        and             payables                      and
                                                                                                                                              and other        other loans            and other         other loans
                                                                                                                                                     £000s                  £000s                  £000s                  £000s

In one year, or less                                                                                                                         571                           31                      183                           -

                                                                                                                                                         571                           31                      183                           -

The Group had £25.0m (31 December 2014: £23.8m) undrawn committed borrowing facilities available and £4.5m of undrawn uncommitted
facility available at 31 December 2015.

Classification of the Group’s financial instruments is set out below:

                                                                                                                                                                                           Loans and    Non-financial                               
                                                                                                                                                                                        receivables                  assets                     Total
As at 31 December 2015                                                                                                                                                    £000s                   £000s                   £000s

Financial assets                                                                                                                                                                                                        
Cash and cash equivalents                                                                                                                                     3,229                             -                     3,229
Trade and other receivables                                                                                                                                 10,705                        925                  11,630
Other non-current assets                                                                                                                                          122                             -                        122

                                                                                                                                                                                14,056                        925                  14,981

                                                                                                                                                                                                    Other    Liabilities not 
                                                                                                                                                                Held for              financial       within scope                               
                                                                                                                                                                 trading             liabilities               of IAS39                     Total
As at 31 December 2015                                                                                                                     £000s                   £000s                   £000s                   £000s

Financial liabilities                                                                                                                                                                                                   
Working capital facility                                                                                                                        -                           31                             -                           31
Long term financial liabilities (exc. issue costs)                                                                              -                  59,918                             -                  59,918
Financial liabilities (exc. issue costs)                                                                                                -                  16,000                             -                  16,000
Trade and other payables                                                                                                                   -                  12,968                        905                  13,873
Other liabilities                                                                                                                                    -                     1,496                             -                     1,496
Corporation tax                                                                                                                                    -                             -                     2,075                     2,075

                                                                                                                                                              -                  90,413                     2,980                  93,393

                                                                                                                                                                                          Loans and     Non-financial                            
                                                                                                                                                                        receivables                 assets                    Total
As at 31 December 2014                                                                                                                                        £000s                  £000s                  £000s

Financial assets                                                                                                                                                                                                        
Cash and cash equivalents                                                                                                                                     1,434                           -                   1,434
Trade and other receivables                                                                                                                                    7,869                      453                   8,322

                                                                                                                                                                                   9,303                      453                   9,756

Alliance Pharma plc | Annual Report 2015 57

21. Financial instruments continued

                                                                                                                                                                                                   Other     Liabilities not 
                                                                                                                                                  Held for              financial       within scope                            
                                                                                                                                                   trading             liabilities              of IAS39                    Total
As at 31 December 2014                                                                                                            £000s                  £000s                  £000s                  £000s

Financial liabilities                                                                                                                                                                                                   
Working capital facility                                                                                                                        -                      414                           -                      414
Long term financial liabilities (exc. issue costs)                                                                              -                 19,500                           -                 19,500
Financial liabilities (exc. issue costs)                                                                                                -                   3,000                           -                   3,000
Trade and other payables                                                                                                                   -                   5,951                      969                   6,920
Corporation tax                                                                                                                                    -                           -                      959                      959
Onerous contracts – current                                                                                                              -                           -                      227                      227

                                                                                                                                                              -                 28,865                   2,155                 31,020

Classification of the Company’s financial instruments is set out below:

                                                                                                                                                                                           Loans and    Non-financial                               
                                                                                                                                                                                        receivables                  assets                     Total
As at 31 December 2015                                                                                                                                                    £000s                   £000s                   £000s

Financial assets                                                                                                                                                                                                        
Trade and other receivables                                                                                                                                           -                           26                           26

                                                                                                                                                                                          -                           26                           26

                                                                                                                                                                                                    Other    Liabilities not 
                                                                                                                                                                                              financial       within scope                               
                                                                                                                                                                                            liabilities               of IAS39                     Total
As at 31 December 2015                                                                                                                                                    £000s                   £000s                   £000s

Financial liabilities                                                                                                                                                                                                   
Working capital facility                                                                                                                                                   30                             -                           30
Trade and other payables                                                                                                                                               -                        571                        571

                                                                                                                                                                                        30                        571                        601

                                                                                                                                                                                          Loans and     Non-financial                            
                                                                                                                                                                        receivables                 assets                    Total
As at 31 December 2014                                                                                                                                        £000s                  £000s                  £000s

Financial assets                                                                                                                                                                                                        
Cash and cash equivalents                                                                                                                                          12                           -                        12
Trade and other receivables                                                                                                                                           -                        25                        25

                                                                                                                                                                                        12                        25                        37

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                                                                                                                                                                                                    Other     Liabilities not 
                                                                                                                                                                             financial       within scope                            
                                                                                                                                                                            liabilities              of IAS39                    Total
As at 31 December 2014                                                                                                                                        £000s                  £000s                  £000s

Financial liabilities                                                                                                                                                                                                   
Trade and other payables                                                                                                                                               1                      182                      183

                                                                                                                                                                                          1                      182                      183

 
58 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

21. Financial instruments continued

Contingent consideration (Level 3)

The fair value of contingent consideration related to the acquisition of MacuVision Europe Limited (see note 35) is estimated using a
present value technique. The £3,674,000 fair value is calculated using the discount rate adjustment technique, taking the most likely
cash flows and discounting at a risk adjusted rate of 10% (see note 11). 

An increase of 5% in estimated cash flows would result in an increase to the fair value of £250,000. A decrease would have the 
opposite effect. 

Level 3 fair value measurements:

The reconciliation of the carrying amounts of financial instruments classified within Level 3 is as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                  Liabilities                Liabilities
                                                                                                                                                                           Note                      £000s                      £000s  

Balance at 1 January 2015                                                                                                                                                                     -                               -  
Acquired through business combination                                                                                                           35                       3,197                               -  
Amount recognised in profit or loss under finance costs                                                                                                               477                               -  

Balance at 31 December 2015                                                                                                                                                       3,674                               -

22. Derivative financial instruments

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                  Liabilities                Liabilities
The Group                                                                                                                                                                                       £000s                      £000s  

Interest rate swap – cash flow hedge                                                                                                                                               120                           129  

Non-current portion                                                                                                                                                                           120                           129  

The cash flow hedges were tested for effectiveness during the year and were found to be highly effective. The ineffective element was
immaterial. The hedge and interest on the bank debt are settled on a quarterly basis on the same date and measured against the same
benchmark, namely 3 month Sterling LIBOR. The amount recognised through the income statement in respect of interest rate swaps during
the year was a charge of £133,000 (year ended 31 December 2014: £140,000).

23. Deferred tax provision

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
The Group                                                                                                                                                                                       £000s                      £000s  

Accelerated capital allowances on tangible assets                                                                                                                        (51)                               6
Temporary differences trading                                                                                                                                                              7                               -
Accelerated allowances on intangible assets                                                                                                                            (4,726)                     (4,699)
Initial recognition of intangible assets from business combination                                                                                       (32,636)                     (1,610)
Interest rate hedge                                                                                                                                                                               21                             26
Share based payments                                                                                                                                                                       390                           162

                                                                                                                                                                                                      (36,995)                     (6,115)

Deferred tax asset                                                                                                                                                                               418                           194

Deferred tax provision                                                                                                                                                                (37,413)                     (6,309)

Alliance Pharma plc | Annual Report 2015 59

23. Deferred tax provision continued
Reconciliation of deferred tax movements:

                                                                                                                                           Recognised
                                                                                                                                                  in other        Recognised        Recognised                              
                                                                                                            31 December  comprehensive     in the income        on business     31 December 
                                                                                                                           2014                income           statement       combination                    2015
The Group                                                                                                       £000s                  £000s                  £000s                  £000s                  £000s

Non-current assets                                                                                                                                                                                       
     Intangible assets                                                                                     (4,699)                           -                      (27)                           -                (4,726)
     Initial recognition of intangible from business combination              (1,610)                           -                      162               (31,188)              (32,636)
     Property, plant and equipment                                                                       6                           -                      (57)                           -                     (51)
Non-current liabilities                                                                                                                                                                                   
     Derivative financial instruments                                                                   26                        (5)                           -                           -                        21
Equity                                                                                                                                                                                                              
     Share option reserve                                                                                    162                           -                      228                           -                      390
Temporary differences                                                                                                                                                                                  
     Trading                                                                                                                -                           -                          7                           -                          7

                                                                                                                        (6,115)                        (5)                      313               (31,188)              (36,995)

Recognised as:                                                                                                                                                                                               
     Deferred tax asset                                                                                        194                                                                                                           418

     Deferred tax liability                                                                                (6,309)                                                                                                   (37,413)

Changes to the UK corporation tax rates were announced in the Chancellor's Budget on 8 July 2015. These include reductions to the main rate
to reduce the rate to 19% from 1 April 2017 and to 18% from 1 April 2020. As the changes were substantively enacted at the balance sheet date
the effects are included in these financial statements (2014: 20%). 

A change to the UK corporation tax rate was announced in the Chancellor's Budget on 16 March 2016, reducing the main rate to 17% from 1
April 2020. As the change was not substantively enacted at the balance sheet date the effect is not included in these financial statements. The
overall effect of this change, if it had applied to the deferred tax balance at the balance sheet date, would be to reduce the deferred tax liability
by an additional £1,083,168 and decrease the tax expense for the period by £403,168. £680,000 of the movement relates to deferred tax
recognised on business combination and would have no impact to the tax expense. 

                                                                                                                                           Recognised
                                                                                                                                                  in other        Recognised        Recognised                              
                                                                                                                  1 January  comprehensive     in the income        on business     31 December  
                                                                                                                           2014                income           statement       combination                    2014
The Group                                                                                                       £000s                  £000s                  £000s                  £000s                  £000s

Non-current assets                                                                                                                                                                                       
     Intangible assets                                                                                     (4,493)                           -                    (206)                           -                 (4,699)
     Initial recognition of intangible from business combination              (1,690)                           -                        80                           -                 (1,610)
     Property, plant and equipment                                                                   (18)                           -                        24                           -                          6
Non-current liabilities                                                                                                                                                                                   
     Derivative financial instruments                                                                 (93)                      119                           -                           -                        26  
Equity                                                                                                                                                                                                              
     Share option reserve                                                                                         -                           -                      162                           -                      162

                                                                                                                        (6,294)                      119                        60                           -                 (6,115)

Recognised as:                                                                                                                                                                                               
     Deferred tax asset                                                                                             -                                                                                                           194

     Deferred tax liability                                                                                (6,294)                                                                                                      (6,309)  

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60 Alliance Pharma plc | Annual Report 2015        

Notes to the Financial Statements continued
for year ended 31 December 2015

24. Provisions for other liabilities 

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
The Group                                                                                                                                                                                       £000s                      £000s  

At start of year                                                                                                                                                                                     227                           389
Amount utilised in year                                                                                                                                                                    (227)                        (180)
Unwinding of discount                                                                                                                                                                             -                             18

At year end                                                                                                                                                                                               -                           227

Leases and associated costs for offices in Newcastle, acquired as part of the Cambridge Laboratories acquisition, had subsequently been
treated as onerous contracts. As at 31 December 2015 an amount of £nil (year ended 31 December 2014: £227,000) discounted at a rate of
10%, representing payments due until the end of each contract, has been recognised. The Newcastle property lease ran until 2015 and has
now ended.

25. Share capital

                                                                                                                                                                                          Allotted, called       Allotted, called 
                                                                                                                                                                                             and fully paid          and fully paid
                                                                                                                                                                                             No. of shares                      £000s  

At 1 January 2014 - ordinary shares of 1p each                                                                                                                264,080,873                        2,641

Issued during the year                                                                                                                                                                   67,492                               -

At 31 December 2014 - ordinary shares of 1p each                                                                                                          264,148,365                        2,641

Issued during the year                                                                                                                                                          204,030,792                        2,041

At 31 December 2015 - ordinary shares of 1p each                                                                                                                468,179,157                         4,682

Between 1 January 2015 and 31 December 2015, 372,245 shares were issued on the exercise of employee share options (2014: 67,492).

Potential issues of ordinary shares

Under the Group's share option scheme for employees and Directors, options have been granted to subscribe for shares in the
Company at prices ranging from 7.75p to 46.75p. Options are exercisable three years after date of grant, but in certain instances this
can be extended to five years. Options outstanding are as follows:

                                                                                                                                                                                                 31 December     31 December 
                                                                                                                                        Exercise price              Exercise                    2015                    2014
Year of grant                                                                                                                                pence                    from              Number              Number

2005                                                                                                                                               19.00                    2008                           -                   9,000
2006                                                                                                                                               18.75                    2009                 27,250                 27,250
2007                                                                                                                                                 9.25                    2010                 19,250                 19,250
2008                                                                                                                                                   8.5                    2011              629,750               629,750
2009                                                                                                                                                 7.75                    2012              679,760               694,060
2010                                                                                                                             33.25 and 34.25                    2013           2,168,125            2,318,325
2011                                                                                                                             34.12 and 31.00                    2014           3,696,831            3,860,081
2012                                                                                                                                               29.25                    2015           2,861,251            3,063,514
2013                                                                                                                             37.25 and 35.75                    2016           4,812,138            5,033,176
2013                                                                                                                                               35.75                    2018           3,300,000            3,700,000
2014                                                                                                                                               33.75                    2017           2,408,268            2,699,056
2015                                                                                                                             43.75 and 46.75                    2018           5,840,271                           -

                                                                                                                                                                                                     26,442,894          22,053,462

Alliance Pharma plc | Annual Report 2015 61

25. Share capital continued

Managing Capital

Our objective in managing the business’ capital structure is to ensure that the Group has the financial capacity, liquidity and flexibility
to support the existing business and to fund acquisition opportunities as they arise.

The capital structure of the Group consists of net bank debt and Shareholders’ equity. At 31 December 2015, net bank debt was £71.5
million, whilst Shareholders’ equity was £162.4 million.

The business is profitable and cash generative. The main financial covenants applying to bank debt are that leverage (the ratio of net
bank debt to EBITDA) should not exceed 3.25 times, interest cover (the ratio of EBITDA to finance charges) should be no less than 4.0
times, and operating cash flows must exceed debt service cash flows. The Group comfortably complied with these covenants in 2015
and 2014.

Smaller acquisitions are typically financed purely with bank debt, while larger acquisitions typically involve a combination of bank debt
and additional equity. The mixture of debt and equity is varied, taking into account the desire to maximise the shareholder returns
while keeping gearing at comfortable levels.

26. Share-based payments
Under the Group's share option scheme for employees and Directors, options to subscribe for shares in the Parent Company are
granted normally once each year. Options are granted with a fixed exercise price equal to the market price of the shares under option
at the date of grant. The contractual life of an option is 10 years from date of grant. Generally, options granted become exercisable on
the third anniversary of the date of grant, but in certain instances this can be extended to five years. Exercise of an option is normally
subject to continued employment. All share-based employee remuneration is settled in equity. Options are valued using the Black-
Scholes option-pricing model. There are generally no performance conditions attached to the options, but 4m of the options granted
on 23 October 2013 are subject to performance criteria and have the extension to five years before they can be exercised. The
assumptions used in the calculation are as follows:

                                                                                                                                                            Number of                                                                    
                                                                                                                                                                    options                                                                     
                                                                                                                        Number of              remaining at
                                                Share price                   Exercise                         options             31 December                   Expected                   Risk free
Grant date                                    at issue                         price                        granted                            2015                    volatility                           rate

04/05/06                                          18.75p                       18.75p                        901,190                         27,250                        14.9%                        4.30%
02/05/07                                            9.25p                         9.25p                     1,402,425                         19,250                        20.4%                        4.62%
23/04/08                                            8.50p                         8.50p                     5,419,950                       629,750                        18.6%                        4.90%
14/04/09                                            7.75p                         7.75p                     2,307,860                       679,760                        25.5%                        4.08%
26/03/10                                          33.25p                       33.25p                     1,300,000                    1,300,000                        43.5%                        3.90%
29/04/10                                          34.25p                       34.25p                     1,502,778                       868,125                        45.7%                        3.90%
28/04/11                                          34.12p                       34.12p                     3,981,916                    3,396,831                        43.9%                        4.10%
21/09/11                                          31.00p                       31.00p                        300,000                       300,000                        53.2%                        4.10%
19/10/12                                          29.25p                       29.25p                     3,494,826                    2,861,251                        49.7%                        1.70%
06/06/13                                          37.25p                       37.25p                     3,370,703                    2,912,138                        49.8%                        2.40%
23/10/13                                          35.75p                       35.75p                     5,900,000                    5,200,000                        49.5%                        2.60%
11/04/14                                          33.75p                       33.75p                     2,726,556                    2,408,268                        49.0%                        2.70%
27/05/15                                          43.75p                       43.75p                     3,840,271                    3,840,271                        47.6%                        2.00%
04/12/15                                          46.75p                       46.75p                     2,000,000                    2,000,000                        45.3%                        2.00%

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In each case, it is assumed the majority of options will be exercised at the earliest opportunity and that on average they are exercised after four
years. The expected volatility is based on historical volatility from 23 December 2003. The risk free rate of return is based on UK government
bonds of a term consistent with the assumed option life.

 
62 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

26. Share based payments continued
Share options and weighted average exercise price are as follows for the reporting periods presented:

                                                                                                                                                                                   2015                                                 2014
                                                                                                                                                                           Weighted                                         Weighted
                                                                                                                                                                             average                                             average
                                                                                                                                                                             exercise                                           exercise
                                                                                                                                                                                   price                                                price  
                                                                                                                                                 Number                  Pence              Number                  Pence

Outstanding at start of year                                                                                              22,053,462                     32.56          20,428,286                   32.43

Granted                                                                                                                                 5,840,271                     44.78            2,726,556                   33.75
Exercised                                                                                                                               (372,245)                     32.58               (67,492)                   13.69
Forfeited                                                                                                                             (1,078,594)                     34.98          (1,033,888)                   34.36

Outstanding at end of year                                                                                               26,442,894                     35.18          22,053,462                   32.56

Exercisable at end of year                                                                                                10,082,217                     35.18            7,557,716                   29.17

Share options were exercised throughout the financial year. Share options were exercised between 7.75 and 37.25 pence per share. 

27. Cash generated from operations 

                                                                                                                                                                                Group                                             Company
                                                                                                                                            Year ended         Year ended        Year ended         Year ended
                                                                                                                                        31 December     31 December     31 December     31 December
                                                                                                                                                       2015                    2014                    2015                    2014
                                                                                                                                                    £000s                  £000s                  £000s                  £000s

Result for the period before tax                                                                                               15,182                 10,157                   1,571                   1,237
Interest payable and similar charges                                                                                       1,971                   1,098                           -                           -
Interest income                                                                                                                              (139)                      (48)                (2,097)                 (1,757)
Other finance costs                                                                                                                        (52)                      (28)                           -                           -
Depreciation of property, plant and equipment                                                                            239                      307                           -                           -
Amortisation/impairment of intangibles                                                                                     199                   1,110                           -                           -
Change in inventories                                                                                                                (6,996)                    (446)                           -                           -
Change in investments                                                                                                                (194)                    (312)                           -                           -
Change in trade and other receivables                                                                                  (3,308)                     2,823                        (1)                        25
Change in trade and other payables                                                                                           2,319                 (1,781)                      388                      (26)
Share based employee remuneration                                                                                          615                      571                      615                      571

Cash generated from operations                                                                                                 9,836                 13,451                      476                        50

28. Capital commitments 
Neither the Group nor Company had any capital commitments at 31 December 2015 or at 31 December 2014.

29. Contingent liabilities 
Neither the Group nor Company had any contingent liabilities at 31 December 2015 or at 31 December 2014.

Alliance Pharma plc | Annual Report 2015 63

30. Pensions 
The Group operates a defined contribution group personal pension scheme for the benefit of certain Directors and employees. 

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
The Group                                                                                                                                                                                       £000s                      £000s  

Contributions payable by the group for the year                                                                                                                             362                           327

The Group also operates a stakeholder pension plan which is available to all employees.

31. Leasing commitments
The future aggregate minimum lease payments under non-cancellable operating leases are as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                    Land and                 Land and
                                                                                                                                                                                                   buildings                  buildings
                                                                                                                                                                                                         £000s                      £000s  

No later than one year                                                                                                                                                                       148                           327
Later than one year and no later than five years                                                                                                                            415                           389
Later than five years                                                                                                                                                                                -                           123

                                                                                                                                                                                                              563                           839

32. Related party transactions 
During the year the Company received funds of £300,000 (year ended 31 December 2014: £270,000) from its subsidiary Alliance
Pharmaceuticals Limited. Net payments of £54,000 (year ended 31 December 2014: £91,000) were made by Alliance Pharmaceuticals
Limited on behalf of Alliance Pharma plc. VAT amounts reclaimed on behalf of Alliance Pharma plc by Alliance Pharmaceuticals
Limited were £69,000 (year ended 31 December 2014: £nil). During the year the Company re-invested £64,010,000 (year ended 31
December 2014: £2,850,000) in Alliance Pharmaceuticals Limited. Interest of £2,064,000 (year ended 31 December 2014: £1,757,000)
was charged to Alliance Pharmaceuticals Limited on the total outstanding debt. During the year an amount of £615,000 (year end 31
December 2014: £571,000) was charged to Alliance Pharmaceuticals Limited by the Company for the employee share-based payment.
The amount owed by Alliance Pharmaceuticals Limited at the year-end is £113,962,000 (31 December 2014: £47,557,000). During the
year the Company re-invested £20,194,000 (year ended 31 December 2014: £nil) in Alliance Pharmaceuticals SAS. Interest of £33,000
(year ended 31 December 2014: £nil) was charged to Alliance Pharmaceuticals SAS on the total outstanding debt. The amount owed
by Alliance Pharmaceuticals SAS at the year-end is £20,228,000 (31 December 2014: £nil).

Dividends declared by Alliance Pharmaceuticals Limited due to the Company are £5,700,000 for the year ended 31 December 2015 (for
the year ended 31 December 2014: £5,400,000). During the year dividends of £5,700,000 were paid by Alliance Pharmaceuticals
Limited to the Company.

During the year the Group made payments on behalf of Unigreg of £719,000 (year ended 31 December 2014: £374,000). Interest
receivable from Unigreg was £48,000 (year ended 31 December 2014: £48,000).

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64 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

33. Joint Ventures 

Name                                                                  Principal Activity                                                                 Country of Incorporation                 % Owned

Unigreg Limited                                                 Distribution of pharmaceutical products to China         British Virgin Islands                                   60
Synthasia International Company Ltd             Distribution of infant milk formula products in China   Hong Kong                                                    20

In accordance with IFRS 11 Joint Arrangements the Group has determined that Unigreg Limited and Synthasia International Company Limited
are Joint Ventures. A Joint Venturer shall recognise its interest in a Joint Venture as an investment and shall account for that investment using
the equity method in accordance with IAS 28 Investments in Associates and Joint Ventures.

Movement in investments in Joint Ventures in the year:

                                                                                                                                                                                                                                          £000s

At 1 January 2015                                                                                                                                                                                                             1,271
Share of post-tax profits of Joint Ventures                                                                                                                                                                       194

At 31 December 2015                                                                                                                                                                                                      1,465

The carrying value of Joint Ventures is split as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                         £000s                      £000s  

Unigreg Limited                                                                                                                                                                               1,003                           791
Synthasia International Company Limited                                                                                                                                       462                           480

Total                                                                                                                                                                                                    1,465                        1,271

Amounts owing from Joint Ventures are as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                         £000s                      £000s  

Unigreg Limited                                                                                                                                                                               1,462                        1,462

Total                                                                                                                                                                                                  1,462                        1,462

The Group’s principal Joint Venture is Unigreg Limited.

The share of the assets, liabilities, revenue and profits of the Group’s principal Joint Venture, Unigreg Limited, which are included in
the Group’s financial statements, are as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                         £000s                      £000s  

Intangible fixed assets                                                                                                                                                                      1,950                        1,950
Current assets                                                                                                                                                                                      836                           397
Current liabilities                                                                                                                                                                              (321)                          (94)
Non-current liabilities                                                                                                                                                                  (1,462)                     (1,462)

Net assets                                                                                                                                                                                          1,003                           791

Alliance Pharma plc | Annual Report 2015 65

33. Joint Ventures continued

                                                                                                                                                                                                Year ended              Year ended
                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                         £000s                      £000s  

Income                                                                                                                                                                                                 914                        1,622
Cost of sales                                                                                                                                                                                     (517)                        (875)
Administration and marketing expenses                                                                                                                                         (116)                        (369)
Finance charges                                                                                                                                                                                 (69)                          (48)  

Profit on ordinary activities before taxation                                                                                                                                     212                           330

Unigreg Ltd, has applied to China’s State Food and Drug Administration (‘SFDA’) to vary the licence for importing Forceval into China. There is
uncertainty about whether or when this variation will be approved. There is a risk that for a period of time Unigreg will be unable to import
further product into China. There are a number of measures to mitigate this risk. The Board’s view is that these mitigation measures are likely
to be sufficient to ensure the continuation of the business in the long term, and that the intangible asset relating to Forceval in China is unlikely
to be impaired. The carrying value of the related intangible asset is £1.95m.

The share of losses of the Group’s individually immaterial Joint Ventures which are included in the Group’s financial statements, are
as follows:

                                                                                                                                                                                            31 December          31 December 
                                                                                                                                                                                                           2015                         2014
                                                                                                                                                                                                         £000s                      £000s  

Loss from continuing operations                                                                                                                                                      (18)                          (11)
Other comprehensive loss                                                                                                                                                                      -                            (8)

Total comprehensive loss                                                                                                                                                                    (18)                          (19)

34. Ultimate controlling party
There is no single ultimate controlling party.

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66 Alliance Pharma plc | Annual Report 2015         

Notes to the Financial Statements continued
for year ended 31 December 2015

35. Acquisitions
1)  MacuVision Europe Limited 

On 2 February 2015, the Group acquired 100% of the share capital of MacuVision Europe Limited (‘MacuVision’). Included in the acquisition
was MacuShield, an eye care treatment designed to be taken by sufferers of dry age-related macular degeneration and other eye conditions. 

The total consideration for the acquisition was between £6.0m and £12.0m. The consideration for the acquisition comprised a base
consideration of £6.0m with an initial payment of £5.5m on 2 February 2015, and a further cash payment of £0.5m in April 2015 in
respect of the net asset value of MacuVision. 

Further contingent consideration of up to £6.0m is dependent on the sales of MacuShield during the two 12 month earnings periods
following acquisition, and is payable in April 2016 and April 2017. 

The fair values of the assets acquired, as at 2 February 2015, are as follows:

                                                                                                                                                            Book value of                                           Fair value of
                                                                                                                                                                 assets and                                              assets and
                                                                                                                                                                    liabilities                Fair value                liabilities
                                                                                                                                                                    acquired           adjustments                 acquired
                                                                                                                                                                         £000s                      £000s                      £000s

Intangible fixed assets                                                                                                                                         27                        8,737                       8,764
Property, plant and equipment                                                                                                                           27                          (17)                            10
Current assets (excluding cash and cash equivalents)                                                                               1,683                               -                       1,683
Cash and cash equivalents                                                                                                                                  78                               -                            78
Current liabilities                                                                                                                                           (1,260)                               -                    (1,260)
Non-current liabilities                                                                                                                                       (31)                               -                          (31)

Net assets                                                                                                                                                           524                        8,720                       9,244
Deferred tax liability                                                                                                                                                -                     (1,748)                    (1,748)
Goodwill                                                                                                                                                                   -                        1,748                       1,748

Fair value of net assets acquired                                                                                                                      524                        8,720                       9,244

Cash paid                                                                                                                                                                                                                          6,047
Cash payable (being £3,563,000 measured at fair value)                                                                                                                                             3,197

Total consideration                                                                                                                                                                                                           9,244

The goodwill that arose on acquisition reflects the opportunity to grow by exploiting new routes to market via the Alliance distribution
network and sales force. None of the goodwill recognised is expected to be deductible for income tax purposes. 

All expenses incurred in the acquisition of MacuVision of £169,000 were recognised within Administration and Marketing expenses. 

The amounts included in the consolidated statement of comprehensive income since 2 February 2015 included revenue of £3.5m and
gross profits of £2.2m. Had the transaction occurred on the first day of the financial year, then estimated contribution to Group
revenues would have been £3.9m and gross profits of £2.4m. 

As at 31 December 2015 the fair value of the contingent consideration was £3.7m compared to an unwound amount of £3.5m,
resulting in a fair value charge to the P&L of £0.2m. This was as a result of forecast sales for the second earnings period exceeding
the original estimate at the time of acquisition. 

Alliance Pharma plc | Annual Report 2015 67

35. Acquisitions continued
2)  Healthcare Products Business from Sinclair IS Pharma plc

On 17 December 2015 the Company completed the acquisition of certain assets and businesses from Sinclair IS Pharma plc. The
acquisition included 27 products including four key growth brands (Kelo-cote, Flammacerium, Aloclair, and Atopiclair).

The acquisition is effected as the purchase of the collection of companies and the acquisition of the product Aloclair not owned by
those companies and their related businesses. The acquisition delivers Alliance a product portfolio operating in fast growing markets
underpinned by geographic expansion and new product introductions. Additionally, the Healthcare Products Business (‘HPB’) offers
Alliance the opportunity to internationalise and transform Alliance into a global leader in specialty pharmaceuticals. Similar to the
product mix of Alliance’s existing products, the product mix of the HPB is a mix of established products and growth products and
follows a buy and build investment strategy.

The Group acquired 100% of the share capital of Advanced Bio-Technologies Inc. (incorporated in Florida, USA), Sinclair Pharma S.r.l.
(incorporated in Italy), Sinclair Pharma France SAS (incorporated in France) and Maelor Laboratories Limited (incorporated in England 
and Wales). 

The total consideration for the acquisition was £127.5m, plus £5.3m for inventory. Total consideration of £131.0m was satisfied on
completion, being £126.3m plus the estimated stock value of £4.7m. A further £1.2m was paid in January 2016 and the remaining
£0.6m is payable on determination of the final stock value. These amounts were satisfied wholly in cash, funded partly by way of new
loans, and partly by the issue and allotment of additional shares. 

The provisional fair values of the assets acquired, as at 17 December 2015, are as follows:

                                                                                                                                                            Book value of                                           Fair value of
                                                                                                                                                                 assets and                                              assets and
                                                                                                                                                                    liabilities                Fair value                liabilities
                                                                                                                                                                    acquired           adjustments                 acquired
                                                                                                                                                                         £000s                      £000s                      £000s

Intangible fixed assets                                                                                                                                    7,416                   128,384                   135,800
Property, plant and equipment                                                                                                                         209                               -                          209
Other non-current assets                                                                                                                                  255                        (133)                          122
Current assets (excluding cash and cash equivalents)                                                                               5,659                        (404)                       5,255
Cash and cash equivalents                                                                                                                                    -                               -                               -
Current liabilities                                                                                                                                                (53)                             53                               -
Non-current liabilities                                                                                                                                     (109)                               -                        (109)

Net assets                                                                                                                                                      13,377                   127,900                   141,277
Deferred tax liability                                                                                                                                                -                   (29,200)                  (29,200)
Goodwill                                                                                                                                                                   -                     20,694                     20,694

Fair value of net assets acquired                                                                                                                 13,377                   119,394                   132,771

Cash paid                                                                                                                                                                                                                      131,000
Cash payable                                                                                                                                                                                                                     1,771

Total consideration                                                                                                                                                                                                      132,771

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The fair values set out above are provisional figures which will be finalised in the 2016 financial statements following management’s final
review of key reconciliations and judgemental areas including intangible fixed assets and acquired inventory balances. 

The fair value of intangible assets recognised on business combination comprise the following product related intangibles: Aloclair, Atopliclair,
Flamma franchise, Kelo-cote, Kelo-stretch, Other Dermatology Products and Other Specialist Hospital Products. 

The goodwill that arose on acquisition reflects the opportunity to grow through the international expansion of the combined business. None of
the goodwill recognised is expected to be deductible for income tax purposes. 

All expenses incurred in the acquisition of the Healthcare business from Sinclair of £1.8m were recognised as non-underlying costs within
Administration and Marketing expenses. 

The amounts included in the consolidated statement of comprehensive income since 17 December 2015 included revenue of £0.8m and gross
profits of £0.5m. Had the transaction occurred on the first day of the financial year, then estimated contribution to Group revenues would have
been £39.4m and gross profits of £23.3m. 

 
68 Alliance Pharma plc | Annual Report 2015         

Supplementary Information

Shareholder Information
Shareholder enquiries

The Company’s share register is maintained on our behalf by Capita Asset Services, who are responsible for updating the register,
including details of changes to shareholders’ addresses and purchases and sales of the Company’s shares. If you have any questions
about your shareholding in the Company or need to notify any changes to your personal details you should write to Capita Asset
Services, PXS1, 34 Beckenham Road, Beckenham, Kent BR3 4ZF or telephone 0871 664 0300 (calls cost 10p per minute plus network
extras, lines are open 9:00am to 5:30pm Monday to Friday).

Financial Calendar
Annual General Meeting                              25 May 2016

Final dividend record date                           17 June 2016

Payment of final dividend                             13 July 2016

Interim results announcement                   September 2016

Year End                                                         31 December 2016

Preliminary announcement                         March 2017

Alliance Pharma plc | Annual Report 2015 69

Shareholder Analysis
Below is an analysis of the share register by size of holding as at 1 March 2016:

                                                                                                                                                             Proportion of              Number of          Proportion of
Size of shareholding                                                                                                                         shareholders            shares held                     shares

1-5,000                                                                                                                                                                27%                   453,450                      0.10%
5,001-10,000                                                                                                                                                       16%                   890,615                      0.19%
10,001-50,000                                                                                                                                                     34%                5,388,392                      1.15%
50,001-100,000                                                                                                                                                     7%                3,468,083                      0.74%
100,001-500,000                                                                                                                                                   7%              12,513,115                      2.67%
500,001-1,000,000                                                                                                                                                2%              14,294,400                      3.05%
1,000,001-5,000,000                                                                                                                                            4%              78,884,509                    16.85%
5,000,001-10,000,000                                                                                                                                          1%              37,617,487                      8.03%
10,000,001-50,000,000                                                                                                                                        2%            314,794,214                    67.22%

                                                                                                                                                                          100%            468,304,265                       100%

As at 1 March 2016 the Company has 736 registered shareholders.

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70 Alliance Pharma plc | Annual Report 2015        

Five Year Summary

                                                                                               Year ended              Year ended              Year ended              Year ended             Year ended
                                                                                                 31 December          31 December          31 December          31 December         31 December
                                                                                                        2011*                       2012*                       2013*                         2014                        2015
                                                                                                                        £m                           £m                           £m                           £m                           £m

Revenue                                                                                             44.1                          42.4                          45.3                          43.5                         48.3
Operating profit before exceptional items                                     12.3                          12.3                          13.3                          11.8                         10.6
Exceptional operating items                                                                 -                               -                               -                            0.6                         (6.3)
Operating profit after exceptional items                                        12.3                          12.3                          13.3                          11.2                         17.0
Profit before tax before exceptional items                                     10.7                          10.8                          12.0                          10.8                           8.9
Profit before tax after exceptional items                                        10.7                          10.8                          12.0                          10.2                         15.2

Intangible assets                                                                              64.2                          77.9                          87.1                          88.9                       259.9
Tangible assets                                                                                   0.8                            0.6                            0.6                            0.4                           1.0
Current assets                                                                                  14.6                          19.5                          16.8                          15.7                         27.8
Current liabilities                                                                              13.6                          21.9                          14.9                          11.4                         31.8
Equity                                                                                                 44.1                          51.8                          64.7                          70.8                       162.4

Average shares in issue (millions)                                                238.6                       240.9                       250.8                       264.1                       272.7
Shares in issue at period end (millions)                                      240.1                       243.0                       264.1                       264.1                       468.2

Earnings per share - basic (p)                                                        3.62                          3.61                          3.82                          3.17                         4.65
Earnings per share - adjusted basic (p)                                         3.62                          3.61                          3.82                          3.36                         3.69

*Restated for impact of IFRS 11 

Alliance Pharma plc | Annual Report 2015 71

Advisors

AUDITOR
Grant Thornton UK LLP
Hartwell House
55-61 Victoria Street
Bristol
BS1 6FT

BANKERS
Lloyds Bank Corporate Markets
The Atrium
Davidson House
Forbury Square
Reading
Berkshire
RG1 3EU

Royal Bank of Scotland
3rd Floor
3 Temple Back East
Bristol
BS1 6DZ

Silicon Valley Bank
Alphabeta
14-18 Finsbury Square
London
EC2A 1BR

CORPORATE ADVISOR
Numis Securities Ltd
10 Paternoster Square
London
EC4M 7LT

FINANCIAL PR
Buchanan Communications
107 Cheapside
London
EC2V 6DN

REGISTRAR
Capita Asset Services
PXS 1
34 Beckenham Road
Beckenham
Kent
BR3 4ZF

REGISTERED OFFICE
Avonbridge House
Bath Road
Chippenham
Wiltshire
SN15 2BB

COMPANY NUMBER
04241478

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72 Alliance Pharma plc | Annual Report 2015         

Cautionary statement regarding forward-looking statements
This Annual Report has been prepared for the members of the Company and no one else. The Company, its Directors, employees or agents do
not accept or assume responsibility to any other person in connection with this document and any such responsibility or liability is expressly
disclaimed.

This Annual Report contains certain forward-looking statements with respect to the principal risks and uncertainties facing Alliance. By their
nature, these statements and forecasts involve risk and uncertainty because they relate to events and depend on circumstances that may or
may not occur in the future. There are a number of factors that could cause actual results or developments to differ materially from those
expressed or implied by these forward-looking statements and forecasts. The forward-looking statements reflect the knowledge and
information available at the date of preparation of this Annual Report, and will not be updated during the year. Nothing in this Annual Report
should be construed as a profit forecast.

The Report of the Directors in this Annual Report has been drawn up and presented in accordance with English company law and the liabilities
of the Directors in connection with that report shall be subject to the limitations and restrictions provided by such law. 

In particular, Directors would be liable to the Company (but not to any third party) if the Report of the Directors contains errors as a result of
recklessness or knowing misstatement or dishonest concealment of a material fact, but would not otherwise be liable.

TRADEMARKS 
The following are registered trademarks of Alliance Pharma plc and subsidiary companies and are protected in a number of countries: 

AbsorbagelTM; AcnisalTM, ALLIANCE, ALLIANCE and Logo, ALLIANCE GENERICS, ALLIANCE PHARMACEUTICALS, AloclairTM, AlostopTM,
AlphadermTM, AnbesolTM, AquadrateTM, Ashton & ParsonsTM, Ashton & Parsons Infants’ PowderTM, AtaraxTM, AtopiclairTM, AvloclorTM, Bio-
corneumTM, Bio-tachesTM, BiotanoidTM, BuccastemTM, Canker-XTM, CeanelTM, ClearWayTM, ClearWay Stoma BridgeTM, ContisolTM, DecapinolTM,
DekapinolTM, DeltacortrilTM, DermachronicTM, DermacideTM, DermamistTM, DermoxylTM, DistamineTM, EffadianeTM, FadiamoneTM, FazolTM, Fazol G
NitrateTM, Fazol GynTM, FlammaceriumTM, FlammaclairTM, FlammasprayTM, FlammasunTM, FlammazineTM, ForcevalTM, Gen-onglesTM, GlydermTM,
HaemopressinTM, HerpclairTM, HydromolTM, IrenatTM, ISIBTM, IsprelorTM, JonctumTM, Kelo-coteTM, Kelo-stretchTM, LiftTM, Lift+TM, Lift PlusTM,
LypsylTM, Lypsyl- It’s On Everyone’s LipsTM, Lypsyl KissablesTM, Lypsyl ShimmerTM, LysovirTM, MacuShieldTM, MacuShield GoldTM, MetedTM,
MolludabTM, NaseptinTM, NaturCareTM, NaturCare BreezeTM, NaturCare FragrantTM, NaturCare ZestTM, NaturCare IPDTM, Nu-SealsTM, OcclusalTM,
OndemetTM, OPUS and Logo, OxyplastineTM, PaludrineTM, PapclairTM, PapuduoTM, PapulexTM, PapustilTM, PavacolTM, Pavacol-DTM, PentraxTM,
PeriostatTM, PermitabsTM, PosidormTM, QuinodermTM, Quinoderm Q deviceTM, RincinolTM, RizudermTM, Roman in a chariot device, SavarineTM,
SebclairTM, SkinSafeTM, SkinSafe Non Sting Protective FilmTM, StemflovaTM, SyntometrineTM, Terra-cortrilTM, T-GoTM, ThwartTM, TimodineTM,
TridesonitTM, Trust the ScienceTM, UnifluTM, UnigregTM, VariquelTM, VibramycineTM, Vita-dermacideTM.

The following are all used under licence by Alliance Pharmaceuticals Limited:

Xenazine is a registered trademark of Biovail Laboratories International (Barbados) 

Gelclair is a registered trademark of Helsinn Healthcare S.A. 

ImmuCyst is a registered trademark of Sanofi Pasteur Limited 

Designed & produced by Design Wall.

Alliance Pharma plc
Avonbridge House
Bath Road
Chippenham
Wiltshire
SN15 2BB
United Kingdom

T:  +44 (0)1249 466966
F:  +44 (0)1249 466977
E:  ir@alliancepharma.co.uk

www.alliancepharma.co.uk