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Instem plc

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FY2020 Annual Report · Instem plc
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A N N UA L   R E P O RT
2020

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6

M o r e   t h a n   6 0 0 
c l i e n t s

Instem has over 600 
customers with its blue 
chip customer base 
consisting of the leading 
pharmaceutical, medical 
device, chemical and 
contract research 
organisations as well as 
academic, government 
and privately funded 
research institutions 
across many sites 
worldwide. These 
include all of the top 
25 pharmaceutical and 
biotech companies such 
as GlaxoSmithKline and 
AstraZeneca.

A n n u a l   R e p o r t

2

CONTENTS

HIGHLIGHTS

CHAIRMAN’S STATEMENT

STRATEGIC REPORT

BOARD OF DIRECTORS

CORPORATE GOVERNANCE STATEMENT

DIRECTORS’ REMUNERATION REPORT

DIRECTORS’ REPORT

DIRECTORS’ RESPONSIBILITY STATEMENT

INDEPENDENT AUDITOR'S REPORT TO THE MEMBERS OF INSTEM PLC

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

COMPANY STATEMENT OF FINANCIAL POSITION

CONSOLIDATED STATEMENT OF CASH FLOWS

COMPANY STATEMENT OF CASH FLOWS

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

COMPANY STATEMENT OF CHANGES IN EQUITY 

ACCOUNTING POLICIES

NOTES TO THE FINANCIAL STATEMENTS

DIRECTORS AND ADVISORS

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8

10

22

24

28

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33

34

44

45

46

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48

49

50

51

66

108

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W e   e s t i m a t e   t h a t 

a p p r o x i m a t e l y 

h a l f   o f   t h e   w o r l d ’ s 

p r e c l i n i c a l   d r u g 

s a f e t y   d a t a   h a s   b e e n 

c o l l e c t e d   o v e r   t h e 

l a s t   2 0   y e a r s   u s i n g 

I n s t e m   s o f t w a r e .

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®

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P o w e r f u l   S o l u t i o n s   •   U n i q u e   P e r s p e c t i v e   •   G l o b a l   C o v e r a g e

Instem is a leading provider of IT solutions & services 
to  the  life  sciences  market  delivering  compelling 
solutions for Study Management and Data Collection; 
Regulatory Solutions for Submissions and Compliance; 
and Informatics-based Insight Generation.

Instem  solutions  are  in  use  by  over  600  customers 
worldwide, including all the largest 25 pharmaceutical 
companies,  enabling  clients  to  bring  life  enhancing 
products to market faster. Instem’s portfolio of software 
solutions and services increases client productivity by 
automating study-related processes while offering the 

unique ability to generate new knowledge through the 
extraction  and  harmonisation  of  actionable  scientific 
information.

Instem products and services now address aspects of the 
entire  drug  development  value  chain,  from  discovery 
through to market launch. Management estimate that 
over 50% of all drugs on the market have been through 
some  part  of  Instem’s  platform  at  some  stage  of  their 
development.  To  learn  more  about  Instem  solutions 
and its mission, please visit instem.com.

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H I G H L I G H T S

W e   a r e   e x t r e m e l y   p l e a s e d   w i t h   o u r   c o n t i n u e d   s t r o n g 

o r g a n i c   g r o w t h   a n d   i n c r e a s i n g   a b i l i t i e s   t o   c r o s s   s e l l   t o 

e x i s t i n g   a n d   n e w   c l i e n t s .

F I N A N C I A L   H I G H L I G H T S

O P E R A T I O N A L   H I G H L I G H T S

•  Revenues increased 10% to £28.2m (2019: 

£25.7m)
• 

Software as a Service (SaaS) revenues 
increased 25% to £8.0m (2019: £6.4m)
•  Recurring revenues (annual support and 
SaaS) increased by 13% to £16.9m (2019: 
£14.9m)

•  Organic revenue growth (excluding 

Leadscope acquisition in November 2019) of 
3% to £26.3m (2019: £25.5m)
•  Adjusted EBITDA* of £5.9m (2019: £4.9m)
•  Reported profit before tax of £2.5m (2019: loss of 

£0.9m)

•  Adjusted profit before tax** of £4.0m (2019: 

£3.2m)

•  Fully diluted earnings per share of 11.6p (2019: 

5.7p loss per share)

•  Adjusted fully diluted earnings per share** of 

19.1p (2019: 18.4p)

•  Cash balance as at 31 December 2020 of £26.7m 
(2019: £6.0m) – reflecting both operating cash 
generation and the oversubscribed placing in July 
2020

• 

Strong performance despite wider market impact 
of COVID-19

•  Placing raising £15m net of expenses for the 
Group to accelerate its acquisition strategy
•  Continued transition to SaaS deployment, 

increasing recurring revenue

•  New business revenue came from a balanced 

blend of new and existing clients

•  Further expansion of footprint in the Asia-Pacific 

region

P O S T   P E R I O D - E N D   H I G H L I G H T S

•  Completed the acquisitions of The Edge 

Software Consultancy (“The Edge”) and d-Wise 
Technologies Inc (“d-wise”)
•  Extending the Group’s reach across the drug 

• 
• 

discovery and development lifecycle
Increasing recurring revenues
Strengthened relationships with existing 
clients

•  Current cash position of circa £14m following 
payment of initial acquisition consideration 
•  Deferred and contingent consideration payable of 

up to approx. £11.1m

*Earnings before interest, tax, depreciation, amortisation, 
impairment of goodwill and capitalised development costs plus 
non-recurring items. 
**After adjusting for the effect of foreign currency exchange on 
the revaluation of inter-company balances included in finance 
income/(costs), non-recurring items, impairment of goodwill and 
capitalised development costs plus amortisation of intangibles on 
acquisitions. 

6

The performance during the Period highlighted our 
resilience – especially given the COVID-19 backdrop. 
Our proven model continues to generate strong cash 
flows while the combination of increasing demand for 
regulatory-backed solutions and a growing demand for 
artificial intelligence and in silico solutions in the drug 
discovery process underpins our confidence in further 
leveraging our product base. Importantly, we already 
have good visibility for the current year with growing 
SaaS revenues and a strong pipeline. 

We are extremely pleased with our continued strong 
organic growth and increasing abilities to cross sell to 
existing and new clients. Furthermore, we are primed 
to build on this momentum, having strengthened our 
proposition post Period end. The recent acquisitions of 
d-wise and The Edge highlight our ability to add scale 
and leverage existing customer relationships with a 
view to further enhancing earnings and profitability, 
while providing a strong platform for continued 
growth. In addition, we are continuing discussions 
with a number of other potential acquisition targets.

Given the structural backdrop and opportunities 
within our existing client base we are confident that 
we are well placed to continue growing recurring 
revenues, margins, and cash generation, and look 
forward to augmenting organic growth via our ongoing 
acquisition strategy.

P J Reason
Chief Executive

H i g h l i g h t s

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"The Instem team continued to 

make an exceptional contribution 

to life sciences R&D in general and 

specifically to the global endeavour 

to rapidly bring safe and effective 

COVID-19 vaccines and therapies to 

market."

D Gare

Non-Executive Chairman

C h a i r m a n ' s   S t a t e m e n t

8

C H A I R M A N ' S   S T A T E M E N T

The  performance  of  the  Group  during  the  Period 
highlights  the  resilience  of  our  business  model  as  we 
generated  growing  cash  flows,  revenues  and  profits 
despite  the  wider  global  economic  malaise  caused  by 
the COVID-19 pandemic.
Whilst,  clearly,  this  pandemic  had,  and  continues 
to  have,  a  destabilising  effect  on  a  number  of  sectors 
and  businesses,  we  were  able  to  take  advantage  of 
the  continued  demand  for  our  leading  solutions  and 
services to the global life sciences market. Further, we 
were  able  to  meet  new  requirements  from  customers 
looking  to  produce  rapid  solutions  for  COVID-19 
related drug and vaccine development projects.
Operationally,  we  continued  to  perform  in  line  with 
market expectations - with a 10% increase in revenues 
year-on-year  and  the  shift  towards  SaaS  continued, 
further increasing visibility. We also successfully raised 
£15m  net  of  expenses  to  accelerate  our  acquisition 
programme  through  the  placing  of  3,620,690  new 
ordinary shares. The combination of strong cash flow 
and  funds  raised  meant  that  the  cash  balance  at  the 
year-end was £26.7m (2019: £6.0m).
Importantly, the investment in our global infrastructure 
and IT, made over recent years, meant that we were able 
to  effectively  operate  across  a  variety  of  geographies 
whilst  continuing  to  deliver  solutions  to  our  clients. 
This  investment  had  been  designed  to  facilitate 
the  requirement  for  a  dispersed  and  continuously 
increasing  remote  business  operation.  With  sections 
of our workforce already working from home prior to 
the pandemic, the onset of COVID-19 highlighted our 
ability  to  continue  delivering  solutions  remotely  with 
minimal disruption.

S T R A T E G I C   D I R E C T I O N
Our ability to add value and integrate businesses rapidly 
was  highlighted  by  the  performance  of  Leadscope, 
which  we  acquired  in  November  2019  and  which 
enabled, our In Silico Solutions business unit to grow 
rapidly during the Period.
We  believe  that  the  momentum  achieved  during  the 
Period provides validation of the strategic potential of 
the  business.  In  particular  we  were  delighted  to  have 
made  notable  progress  on  a  number  of  fronts  during 
the Period, namely:
•  Continued  growth  in  SaaS-based  revenues  both 
through  new  business  wins  and  via  the  ongoing 
conversion of existing clients. As such, SaaS-based 
revenue  increased  25%  to  £8.03m  during  the 
Period;

•  The expansion of "technology enabled outsourced 
services",  where  2020  revenue  was  £6.2m  (2019: 
£5.6m):

•  Our market leading offering for the SEND services 
business  continued  to  perform  well  during  the 
Period.

A C Q U I S I T I V E   G R O W T H
One of the Group’s key long-term objectives has been to 
acquire complementary technologies or enter adjacent 
markets  –  and  given  the  wealth  of  opportunity,  we 
chose  to  raise  £15m  in  July  2020  to  accelerate  this 
strategy.  We  are  delighted  to  have  acquired  d-wise 
and The Edge post Period end. Both companies bring 
strong  management  teams  and  synergies  with  our 
existing  business  and  client  base.  We  believe  they 
will  be  integrated  easily  and  will  quickly  be  earnings 
enhancing,  whilst  also  extending  our  reach  from 
discovery to clinical trial across the drug discovery and 
development lifecycle.
When  we  combine  the  performance  of  the  business 
in  the  recent  past  with  the  impact  of  the  two  recent 
acquisitions,  the  step  change  in  the  scale  of  our 
operations is strategically significant. We are extremely 
excited about the potential we have for new horizons.

B O A R D
While  the  business  has  performed  extremely  well 
over  recent  years,  the  Board  recognises  that  it  is  not 
currently fully compliant with the QCA guidelines for 
corporate  governance  regarding  the  independence  of 
non-executive  directors.    We  intend  to  address  this 
situation  through  additional  non-executive  director 
appointment  during  the  next  12  months.  We  look 
forward to updating shareholders on our efforts in due 
course.

S U M M A R Y
Finally, on behalf of the Board, I would like to thank and 
congratulate  the  entire  Instem  team,  who  performed 
admirably  despite  the  often  significant  challenges 
having to adjust to home based working, lock downs, 
home  schooling  and  the  many  other  impacts  of 
COVID-19.  Despite  these  challenges,  the  Instem 
team  continued  to  make  an  exceptional  contribution 
to life sciences R&D in general and specifically to the 
global  endeavour  to  rapidly  bring  safe  and  effective 
COVID-19 vaccines and therapies to market.

D Gare
Non-Executive Chairman

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S T R A T E G I C   R E P O R T

S T R A T E G I C   D E V E L O P M E N T

The  Group  continued  to  enhance  its  position  across 
all parts of the business with growth underpinned by 
the ongoing move to a SaaS model, resulting in further 
margin  growth  during  the  Period.  Importantly,  this 
shift is in train with the majority of clients, providing 
increased visibility in the overall direction of travel. 
The Group has a broad portfolio of products, providing 
a growing range of solutions to existing and new clients 
across  the  drug  discovery  and  development  lifecycle, 
and  a  strong  platform  for  increased  cross-selling  and 
up-selling  opportunities.  Importantly  during  the 
Period,  the  Group  fully  integrated  Leadscope,  which 
was  acquired  in  November  2019,  further  enhancing 
performance.
The focus remains on building on this success, with the 
Group primed for further acquisitive growth following 
the recent acquisitions of d-wise and The Edge - having 
successfully  raised  £15m  net  of  expenses  during  the 
Period  to  accelerate  our  acquisition  strategy.  Active 
discussions are ongoing with a number of targets, with 
the  aim  of  further  driving  value  across  our  existing 
solutions  with  the  possibility  of  also  broadening  our 
portfolio. 

M A R K E T   R E V I E W

The  market  backdrop  continues  to  be  favourable 
for  the  Group  given  global  population  growth  and 
life  expectancy  underpinning 
increased  demand 
for  successful  innovation  in  life  sciences.  Increasing 
amounts  of  money  are  being  invested  in  the  biotech 
industry  with  the  pharmaceuticals  sector  investing 
heavily  in  drug  development,  underpinning  a  strong 
pipeline  for  Instem.  The  market  dynamics  were 
highlighted further by the onset of COVID-19, which 
presented  a  number  of  new  opportunities  as  R&D 
increased  with  all  the  major  companies  focusing  on 
developing vaccines or therapies.
In  the  pharmaceutical  industry,  which  represents  the 
largest proportion of Instem's revenue, we refer again 
to the Pharma R&D Annual Review, the 2021 version 
of which was released by Pharma Intelligence in March 
this  year.  This  report  shows  that  the  industry  grew 
strongly  in  the  last  12  months  with  a  4.8%  increase 
(2019:  9.6%)  in  the  total  number  of  drugs  in  the 
regulatory  stages  of  global  R&D,  continuing  a  multi-
year growth trend that, subject to the potential impact 
of COVID-19, shows no sign of abating. Most relevant 

to Instem was the 6.0% increase (2019: 13.2%) in the 
number  of  drugs  at  the  preclinical  (or  non-clinical) 
phase of drug development, that accounted for much 
of our business.
The  constant  development  of  the  drug  discovery 
pipeline  continues  to  drive  demand  for  Instem’s 
solutions  –  enabling  companies  to  provide  faster  and 
cheaper routes to market. Importantly, the regulatory-
backed  Standard  for  the  Exchange  of  Non-clinical 
Data  ("SEND")  continues  to  underpin  longer  term 
opportunity  and  visibility.  Further  regulatory-backed 
business lines were added to the Group’s portfolio with 
the  acquisition  of  Leadscope,  providing  solutions  for 
the ICH M7 (R1) standard. 

B U S I N E S S   P E R F O R M A N C E

S T U D Y   M A N A G E M E N T   A N D 
D A T A   C O L L E C T I O N

Performance here was relatively flat as expected, mainly 
as  a  result  of  the  fact  that  revenue  recognition  from 
certain  contracts  won  during  the  Period  will  not  be 
recognised until the current financial year, coinciding 
with  client  deployment  and  the  commencement  of 
annual support payments. 
Encouragingly,  the  transition  to  SaaS  continued  at 
pace,  outstripping  management’s  expectations  –  with 
the accelerated growth meaning there were fewer new 
perpetual software licenses, and correspondingly lower 
annual support and maintenance fees. 
We  were  delighted  to  add  Biotoxtech,  a  prominent 
non-clinical Contract Research Organization in South 
Korea,  as  a  new  client  during  the  Period  –  further 
enhancing  the  Group’s  footprint  in  the  Asia  Pacific 
region. The contract, worth approximately $1 million, 
is  for  Instem  to  provide  a  comprehensive  package  of 
preclinical  data  collection,  analysis  and  regulatory 
submissions  management  solutions  to  automate  and 
optimise study related processes.
Separately,  the  Group  was  awarded  new  business 
with an existing client worth c.£2.2m, which has been 
extended  by  a  further  $0.8m  order  post  period  end. 
The new contracts combined Study Management and 
Regulatory Solutions products and services, including 
the expansion of the client's Provantis user base by over 
25% - reflecting the continuing growth in non-clinical 
research  and  development.  Among  other  things,  the 

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funded product development work under this contract 
will involve Provantis integration with a leading third 
party digital pathology solution, offering the potential 
for  significant  future  productivity  enhancement  and 
facilitating  the  work  of  an  increasingly  distributed 
pathologist community.

I N   S I L I C O   S O L U T I O N S

The  Group  continued  to  generate  strong  In  Silico 
Solutions  (previously  Informatics)  revenue  growth, 
which  benefitted  from  strong  organic  growth  as  well 
as  a  full  year’s  trading  from  Leadscope,  acquired  in 
November 2019. The addition of Leadscope broadened 
the  Group’s  in  silico  reach,  which  now  incorporates 
drug  discovery  through  to  early  deployment  and 
beyond, providing a more rounded offering for existing 
and new clients. 
Having 
integrated  Leadscope,  which  only 
contributed six-weeks trading in 2019, the Group was 
able to drive significant in silico solutions returns, with 
comparative revenues more than doubling to £3.3m. 

fully 

R E G U L A T O R Y   S O L U T I O N S

Every drug company is required to submit non-clinical 
data in the SEND format to the FDA (Food and Drug 
Administration) as part of the processes for testing and 
getting  approval  for  a  new  drug.  This  means  that  the 
combination  of  the  industry’s  focus  on  addressing  a 
backlog of SEND conversion work in addition to this 
standard extending to new study types, provides a solid 
platform for continued growth.
Instem’s  technology  creates,  manages  and  visualizes 
SEND  datasets  while 
the  Group  also  provides 
technology-enabled  outsourced  services,  enabling 
customers to make FDA submissions with confidence. 
The industry is increasingly looking to unlock silos of 
information  and    importantly,  customers  are  starting 
to contemplate Instem’s SEND solutions as a consistent 
approach  to  leveraging  their  valuable  historic  studies 
for  more  efficient  and  effective  research.  This  is 
providing a growing source of revenue for the Group, 
highlighted  through  a  £0.7m  top-30  pharmaceutical 
company contract for conversion of historical studies 
to the SEND format, won during the Period.
Furthermore,  as  part  of  the  £2.2m  contract  with  an 
existing client (mentioned above), Instem will provide 
SEND  staff  augmentation  support,  which  will  act  as 
an  extension  of  the  client’s  staff  to  help  address  both 
current and growing future demand (and backlog) for 
SEND study services. 

E N V I R O N M E N T A L ,   S O C I A L   A N D 
G O V E R N A N C E   ( E S G )

Position and Mission
Instem is a leading provider of IT solutions and services 
to the life science market with a mission to enable our 
customers  to  bring  their  life  enhancing  products  to 
market faster. 
Our  core  values  underlying  our  approach  to  this 
mission are summarized by the acronym, “RECIPe”: 
•  Offer Respect in our dealings with each other
•  Empower everyone to add real value at every stage
•  Be Creative in our solutions
• 
•  Be Passionate in our execution
•  Leading to enjoyment in our working lives

Show Integrity in dealing with issues

Organisational Governance
At Instem, the Executive management team, under the 
direction  of  the  Board  of  Directors  strives  to  attend 
to  the  interests  of  all  its  stakeholders.  Shareholders’ 
interests are also aligned with the long-term incentive 
plan  provided  to  senior  management,  achievement 
of  which  is  based  on  increasing  the  Instem  share 
price. Instem’s Board of Directors is committed to an 
appropriate composition of the Board and is currently 
considering  ways  of  achieving  this  by  engaging 
institutional  shareholders  and  external  advisors 
for  their  views.  It  is  the  intention  that  there  will  be 
additional non-executive director appointment during 
the next 12 months.
Instem  is  committed  to  having  effective  governance 
practices to support its pursuit of its objectives, using 
appropriate  management  processes  and  systems 
to  deliver  the  highest  standards  of  ethical  business 
conduct and corporate governance.
To  further  support  these  goals,  a  Governance,  Risk 
management and Compliance (GRC) department, has 
recently been set up with the aim of providing Instem 
with a collection of capabilities that allows the business 
to  reliably  manage  governance,  identify  and  manage 
risks, and to provide an independent audit function to 
ensure the business remains compliant accordingly.
The Board of Directors is responsible for the oversight 
of risks facing the Group, and the ESG subjects (such 
as  social,  ethical,  environmental,  legal  and  regulatory 
compliance,  business  model  resilience)  will,  where 
appropriate,  be  included  within  the  Group’s  board 
meetings which are generally held bi-monthly. 

1 1

S T R A T E G I C   R E P O R T   ( C O N T I N U E D )

Human Rights
As a vendor of software and associated services, Instem 
operates in the highly regulated and ethically minded 
life  sciences  industry  where  there  is  not  a  prevalence 
for human rights issues. 
Internally,  Instem  has  implemented  policies  to  cover 
areas such as a modern slavery, anti-bribery, diversity, 
equality  and  inclusion,  both  during  the  recruitment 
process and while staff are in employment.  The human 
resources  Policy  and  Culture  handbooks,  together 
with  our  procurement  practices    ensure  Instem  and 
third  party  staff  are  treated  fairly  and  employed  in 
accordance  with  all  relevant  laws  and  regulations  for 
the locations in which they are based.
Procedures are in place to support the Group’s policy 
that  disabled  persons,  whether  registered  or  not, 
shall  be  considered  for  employment  and  subsequent 
training, career development and promotion. 

Employment Practices 
Instem’s staff are a key component in the success of the 
business and in respect to this Instem has a dedicated 
Human Resources team that have implemented policies 
to support staff during their employment. 
Annual  staff  surveys,  incorporating  both  Gallup  Q12 
and Great Place to Work concepts, are undertaken by 
the  HR  team  to  ensure  our  staff  have  an  opportunity 
to express views on a wide range of employment and 
social  issues.  Regular  staff  reviews  offer  additional 
opportunities  for  such  communications  as  well  as  to 
guide  training  and  skills  development.  The  results  of 
the  2020  staff  survey  demonstrated  that  82%  of  the 
employees regard Instem as a great place to work.
An  internal  Kudos  Award  programme  and  Thanks 
Badges  are  established  to  recognise  exceptional 
performance.
Health and well-being for staff was promoted through 
employee  communication  channels  and  subsidised 
healthcare provision.
Due to the impact of COVID-19 on working practices, 
for 2020 Instem introduced a series of flexible working, 
homeworking  and  holiday  policies  to  support  the 
workforce 
the  difficulties  of  balancing 
childcare  with  work  commitments.  Regular  staff 
surveys  were  also  conducted  and  provided  staff  with 
an opportunity to provide feedback on any issues they 
were facing, in order for Instem to provide support as 
appropriate. 

through 

Environment – Our Environmental impact
At  Instem,  we  understand  our  responsibility  to 
ensure  that  we  are  acting  responsibly  in  regard  to 
the  environment.  For  this  reason,  in  2021  we  are 
implementing  a  new  Environmental  Strategy  across 
the group, with the objective of ensuring Instem does 
not disproportionately impact the environment as part 
of its business activities.
The    environmental  strategy  will  be  implemented 
through  a  new  Environmental  Management  System 
(based  on  the  framework  of  ISO  14001),  with  the 
intention  of  improving  the  overall  environmental 
performance  of  the  Group,  considering    both  our 
organisational profile and the local laws and regulation 
in which Instem offices are located. 
An  Environmental  Management  Group  will  oversee 
our  environmental  management  system,  including 
representatives  from  Human  Resources,  Information 
Services  and  Governance,  Risk  Management  and 
Compliance.

IT Equipment Waste Management
We already ensure that as a Group we are participating 
in  a  programme  to  recycle  or  re-purpose  100%  of  all 
I.T equipment used internally. 
In  addition  to  the  above  requirement  one  company 
within the group, which is defined as a manufacturer 
submitted  its  annual  Waste  Electrical  and  Electronic 
Equipment (WEEE) return.

Impact of Greenhouse Gas Emission:
As  per  our  mandatory  reporting  of  greenhouse 
gas  emission  pursuant  to  the  Companies  Act  2006 
(Strategic  Report  and  Directors’  Report)  Regulations 
2013,  the  Group  has  reviewed  the  requirements  of 
the  Environmental  Reporting  guidelines.  For  each 
Company in the group that is qualified as large, their 
total  energy  consumption  is  below  40MWh  and 
therefore the Group and Company are not required to 
prepare an Energy and Carbon Report to be included 
within this Annual Report.

Task Force for Climate-related Financial Disclosures 
(TCFD)
The  TCFD  was  established  by  the  Financial  Stability 
Board  to  review  how  the  climate-related  issues  has 
been  reviewed  by  the  financial  sector.  The  TCFD 
has  established  a  series  of  recommendations  on  the 
disclosures which organisations should include in their 
annual report, which would cover

1 2

•  Governance
• 
Strategy 
•  Risk Management
•  Metrics and targets
As part of our responsibility to manage our contribution 
to long-term climate change, we will also include the 
recommendations from the TCFD as part of our new 
Environmental Strategy. This will assist informing our 
stakeholders  our  climate-related  financial  risks  and 
how we manage these. 
Within  this  year  we  will  seek  to  ensure  that  we  will 
develop  and  implement  our  actions  against  the  core 
areas  mentioned  above  and  we  will  evaluate  our 
progress on a regular basis.  

Ethical Operating Practices 
Instem  places  a  high  emphasis  on  conducting  its 
business  with  honesty  and  integrity,  and  this  forms 
part of our core values. The highest ethical standards 
are expected of management and employees alike and 
we continuously strive to create a corporate culture of 
honesty, integrity, and trust. 
Instem  has  implemented  policies  such  as  Anti-
Corruption and Anti-Bribery and Corporate Criminal 
Offences  with  the  HR  policy  and  culture  handbooks 
ensuring  staff  understand  their  responsibilities  in 
relation to ethical matters.  Ethics and Code of Conduct 
training is also mandatory training for all staff. 

Customer Issues
Instem  has  a  clear  strategic  objective  of  meeting  its 
customer’s  needs  and  expectations  in  the  products 
and services that are supplied to them. The following 
processes help Instem achieve this aim: 
Software Development and Deployment
Instem  has  a  comprehensive  Software  Development 
Lifecycle  and  robust  testing  processes  that  are 
overseen  by  Instem’s  ISO9001:2015  certified  Quality 
Management System.  
SaaS deployment of Instem solutions has enabled our 
customers to reduce their own I.T. infrastructure. 100% 
network  availability  was  achieved  for  SaaS  customers 
during 2020.   
Customer Support
Instem  offers  various  support  services  to  help  our 
Instem  solutions  efficiently  and 
customers  use 
effectively.  These  include,  installation  and  technical 
configuration support, training, validation, consultancy 
and a global helpdesk. 
Instem  also  strives  to  meet  customer’s  need  and 
expectations  by  regularly  enhancing  our  software 
through new functionality and software changes. 

Data Protection 
Instem  has  a  Group  wide  data  protection  policy  that 
sets  out  processes  and  the  legal  conditions  that  must 
be  satisfied  in  relation  to  the  obtaining,  handling, 
processing,  storage,  transferring  and  destruction  of 
personal information. 
Information Security
At Instem, Information Security is embedded into all 
aspects of business function and we use a combination 
of technical, administrative and procedural controls to 
protect IT and information from being compromised. 
Instem’s  security  controls  are  managed  according  to 
our  ISO  27001:2013  certified  information  security 
management system (ISMS) and implemented through 
a combination of people, technology and processes.

Community Involvement and Development
With  employees  around  the  globe,  we  believe  it  is 
important  that  we  consider  how  our  presence  can 
benefit the local communities in which we operate. We 
also consider common cultural threads that unite us as 
a global organisation, while meeting the needs of our 
employees in every region.
Elements of this include:
• 

Supporting  a  number  of  Charities  including 
matched-funding of employee fundraising events. 
•  Partnering with the INSPIRE Safety Pharmacology 
Horizon 2020 project which includes funding two 
PhD students.

S E C T I O N   1 7 2   S T A T E M E N T
In  accordance  with  section  172  of  the  Companies 
Act  2006  the  Directors,  collectively  and  individually, 
confirm that during the year ended 31 December 2020, 
they acted in good faith and have upheld their ‘duty to 
promote the success of the Group’ to the benefit of its 
stakeholder groups. 
Directors  acknowledge  the  importance  of  forming 
and  retaining  a  constructive  relationship  with  all 
stakeholder  groups.  Effective  engagement  with 
stakeholders  enables  the  Board  to  ensure  stakeholder 
interests  are  considered  when  making  decisions  and 
is  crucial  for  achieving  the  long-term  success  of  the 
Group. 
Instem identifies five key stakeholder groups associated 
with our business:
•  Employees
•  Clients
• 
•  Partners
•  Communities in which we operate

Shareholders

1 3

S T R A T E G I C   R E P O R T   ( C O N T I N U E D )

Employees
We  recognise  that  our  employees  are  critical  to  the 
success  of  our  business  and  we  focus  considerable 
attention  on 
their  positive  engagement.  This 
commences  from  their  initial  induction  into  the 
Group where new joiners are introduced to our Group 
Values  and  our  Culture  Handbook,  which  provide  a 
framework for ensuring an alignment between Group 
and  employee  interests.    There  is  frequent  and  open 
communication with employees, who are encouraged 
to  share  their  opinions,  informally  and  through 
regular surveys, both attributable and anonymous.  We 
have  consistently  used  the  Gallup  Q12  engagement 
questions  in  our  surveys  to  identify  trends  and  our 
survey questions have been expanded over recent years 
to align with those used by the Great Place to Work® 
organization.    Employee-led,  location  specific  Action 
Groups  propose  and  implement  changes  to  address 
employee  identified  opportunities  for  improvement. 
Proposals are considered by the Executive management 
team and actioned accordingly. For further details on 
our employees, please see page 12.

Clients
We are fortunate to operate in an industry that has a 
highly collaborative culture with many businesses and 
scientific  related  societies  and  organisations.    Instem 
participates widely in these groups, networking closely 
with our clients and prospects, often taking a leadership 
role based on the considerable expertise of our staff and 
the broad experience we gain from working with many 
clients.    In  addition,  Instem  organizes  multiple  client 
engagement  forums  related  to  sectors  of  our  market, 
specific  products  and  common  industry  practices  or 
regulation.    These  Special  Interest  Groups  provide 
input to strategy and operations, allowing us to ensure 
that  our  products  and  services  meet  the  needs  of  the 
entire client (and prospect) community.
We survey our clients annually and, more regularly, at 
the completion of each project and as we address each 
client support call.  These surveys also help us to plan 
and prioritise changes to our products, services and the 
broader  engagement  we  have  with  clients  across  our 
business.
Our  Client  Strategic  Advisory  Board 
(“SAB”), 
comprises senior staff with a broad industry perspective 
and  from  a  variety  of  client  organisations.  The  SAB, 
which meets twice per year, is tasked with informing/
validating  Instem  high-level  business,  product  and 

service strategy to ensure we maximise our mission to 
enable our clients to bring their life enhancing products 
to market faster.

Shareholders
With  the  professional  guidance  of  our  broker  and 
nominated adviser, N+1 Singer, and our financial public 
relations  advisers,  Walbrook  PR,  the  Group  engages 
with  shareholders  through  multiple  channels,  aiming 
to  provide  clear  and  informative  updates.    Regulated 
News  Service  releases  are  provided  regularly,  both 
those required as an AIM-listed business and additional 
releases  to  keep  shareholders,  and  the  wider  market, 
informed about interesting business developments.  We 
undertake  multi-day  institutional  investor  roadshows 
following  the  announcement  of  interim  and  full-year 
results, which provides an opportunity to also engage 
with a wider group of financial analysts and media.  We 
also took the opportunity to engage with institutional 
shareholders  through  the  2020  equity  fund  raising 
exercise.  We  typically  also  organise  or  attend  retail 
investor events, to ensure all shareholders have access 
to executive management on a regular basis.
As  broker  research  is  typically  not  available  to  all 
shareholders,  we  engage  Progressive  Equity  Research 
to produce additional analyst research, which is freely 
available  from  the  Instem  Investor  Centre  website 
and through other investor channels.  In addition, we 
subscribe for services from Proactive Investor who make 
a range of Instem video and audio interviews available 
for  shareholder  and  wider  investor  consumption, 
aggregated with their own financial journalist coverage 
of Instem news.
While  our  annual  general  meeting  typically  attracts 
very 
independent  shareholders,  voting  on 
shareholder  resolutions  provides  a  formal  avenue  to 
receive  shareholder  feedback  and  an  opportunity  for 
us  to  consider  the  implications  should  resolutions 
not pass unanimously.  We also take note of feedback 
from shareholder representative groups, who typically 
provide  structured  feedback  ahead  of  annual  general 
meetings.

few 

Partners
Instem has a number of strategic partners, with whom 
we actively engage to enhance our portfolio of world-
leading  products  and  services.    Formal  agreements 
govern  these  relationships  and  nominated  Instem 
employees  are  responsible  for  maintaining  a  regular 
and  open  dialogue  to  ensure  ongoing  alignment 

1 4

of  interests.    We  frequently  engage  our  partners  in 
the  wide  variety  of  methods  of  client  engagement 
described above to ensure they have a direct two-way 
line of communication with the end-users.

impact 

Communities
Instem  has  several  offices  around  the  world  and 
many employees who work from home. We recognise 
our  role  as  responsible  employers  and  community 
representatives and encourage and support our staff in 
this regard, regularly providing matching funding for 
charitable activities.  There are regular staff organised 
fund raising events and other activities to support local 
causes  that  occur  within  our  offices.  Clearly  this  has 
been harder to accomplish during office lockdown but 
we  have  done  so  wherever  possible,  for  example  we 
have continued to pay our office cleaning staff despite 
offices being closed.
With  only  office  (and  home)  based  activities,  our 
environmental 
is  generally  quite  modest 
although  we  do  encourage  efficient  energy  usage  and 
recycling  in  office  locations  (see  the  ESG  report  on 
page  11).    We  also  consider  energy  usage  with  our 
external data centre partners as our clients increasingly 
adopt  our  SaaS  solutions  increasing  our  data  centre 
footprint.  Through investment in technology, staff in 
the right places and changing business practices, we are 
also striving to reduce the amount of air travel for staff 
between  our  international  offices  and  to  our  globally 
dispersed client-base.
Significantly from a global community perspective, we 
also recognise the considerable role we play in helping 
our  clients  to  provide  their  life  enhancing  products 
across  the  world.    We  continually  assess  how  we  can 
optimise  what  we  do  to  accelerate  the  availability  of 
safe and effective drugs, vaccines and medical devices, 
as well as safer and more effective agrochemicals, that 
help  to  increase  production  to  feed  an  ever-growing 
world population. 

1 5

S T R A T E G I C   R E P O R T   ( C O N T I N U E D )

F I N A N C I A L   R E V I E W

Key Performance Indicators (KPIs)
The directors review monthly revenue and operating costs to ensure that sufficient cash resources are available for the 
working capital requirements of the Group. Primary KPIs at the year end were:

12 mths to 31 Dec 2020
£000

12 mths to 31 Dec 2019
£000

Total revenue

Recurring revenue*

Recurring revenue as a percentage of total revenue

Adjusted EBITDA**

Adjusted EBITDA Margin %

Cash and cash equivalents

28,217

16,941

60%

5,919

21.0%

26,724

25,717

14,862

58%

4,864

18.9%

5,957

% Change

10%

13%

+200bps

22%

+210bps

349%

* Recurring revenue includes Annual support fees and SaaS subscription and support fees.
** Earnings before interest, tax, depreciation, amortisation, impairment of goodwill and capitalised development costs 
plus non-recurring costs.

Inc 

fees, 

including  Leadscope 

In  addition,  non-financial  KPIs  are  periodically 
reviewed  and  assessed,  including  customer  and  staff 
retention rates.
Instem’s  revenue  model  consists  of  perpetual  licence 
income  with  annual  support  and  maintenance 
contracts,  professional 
technology  enabled 
outsourced services fees and SaaS subscriptions. 
Total  revenues  increased  by  10%  to  £28.2m  (2019: 
£25.7m) 
(‘Leadscope’) 
revenue, which was acquired in November 2019. Total 
organic  revenue  increased  by  3%  to  £26.3m  (2019: 
£25.7m).  Recurring  revenue,  comprising  Support 
&  Maintenance  contracts  and  SaaS  subscriptions, 
increased  during  the  year  by  13%  to  £16.9m  (2019: 
£14.9m).  Recurring  revenue  as  a  percentage  of 
total  revenue  was  60%  (2019:  58%).  Revenue  from 
technology  enabled  outsourced  services  increased  to 
£6.2m  (2019:  £5.6m).  Operating  expenses  increased 
by  7%  in  the  Period  reflecting  the  addition  of  the 
Leadscope cost base, ongoing investment in operational 
teams and higher third-party costs associated with the 
revenue mix, offset by savings in business travel due to 
the pandemic. 
Earnings 
depreciation, 
interest, 
amortisation,  impairment  of  goodwill  and  capitalised 
development  costplus  non-recurring  items  (Adjusted 

before 

tax, 

EBITDA)  increased  by  20%  to  £5.9m  (2019:  £4.9m).  
Excluding  Leadscope,  the  total  comparable  Adjusted 
EBITDA increased by 13% to £5.3m (2019: £4.7m). The 
EBITDA margin as a percentage of revenue increased 
in the year to 21.0% from 18.9% in 2019. 
Non-recurring costs in the year of £0.6m (2019: £0.3m) 
included £0.5m of acquisition costs and £0.1m of legal 
costs associated with historical contract disputes (2019: 
£0.2m acquisition costs and £0.1m legal costs).
The reported profit before tax for the year was £2.5m 
(2019:  loss  of  £0.9m).  Adjusted  profit  before  tax  (i.e. 
adjusting  for  the  effect  of  foreign  currency  exchange 
on the revaluation of inter-company balances included 
in  finance 
items, 
impairment  of  goodwill  and  capitalised  development 
costs plus amortisation of intangibles on acquisitions) 
was £4.0m (2019: £3.2m).  
The total income tax charge in the year of £0.3m (2019: 
£0.02m) represents 10.8% of the Group’s profit before 
tax  (2019:  2.4%  of  the  Group’s  loss  before  tax),  with 
the  reduction  against  the  United  Kingdom  corporate 
tax  rate  of  19%  due  to  the  Group’s  ability  to  receive 
additional  tax  relief  on  its  research  and  development 
expenditure.  This  additional  relief  is  expected  to 
continue into future years.

income/(costs),  non-recurring 

1 6

d-wise  positions  the  enlarged  Group  as  the  foremost 
authority  and  driving  force  in  generating,  analysing 
and leveraging data from Discovery through late-stage 
Clinical  Trials. The  total  consideration  is  up  to  $31m 
comprising  $20m  on  completion,  $8m  of  deferred 
consideration and up to a further $3m which is payable 
contingent  upon  the  future  financial  performance  of 
d-wise. The initial consideration on completion is being 
satisfied by $13m in cash and $7m via the issuance of 
868,203 new ordinary shares of 10p each in Instem plc. 
The  cash  is  being  funded  from  the  Group’s  existing 
financial resources.
The  Group’s  legacy  defined  benefit  pension  scheme 
continues to remain closed to new members and future 
accrual.  The  most  recent  triennial  actuarial  valuation 
of  the  Scheme  was  due  as  at  5  April  2020  with  the 
results  expected  to  be  announced  along  with  the 
publication  of  the  Group’s  interim  results  for  the  six-
month  Period  ending  30  June  2021.  At  31  December 
2020,  the  IAS19  accounting  pension  deficit  increased 
by  £2.1m  to  £3.9m  (2019:  £1.8m).  The  agreed  Group 
cash  contributions  currently  approximate  to  £0.5m 
per  annum,  payable  through  to  October  2024.  The 
deficit at the 2020 year-end of £3.9m (2019: £1.8m) is 
represented by the fair value of assets of £12.5m (2019: 
£12.0m) and the present value of funded obligations of 
£16.4m (2019: £13.8m), after applying a discount rate 
of 1.40% (2019: 2.20%).

The Group continues to maintain its investment in its 
product  portfolio.  Research  and  development  costs 
incurred during the year were £3.4m (2019: £3.0m), of 
which £1.2m (2019: £1.3m) was capitalised. 
The Group operates internationally and is exposed to 
foreign currency risk on transactions denominated in 
a currency other than the functional currency and on 
the  translation  of  the  statement  of  financial  position 
and  statement  of  comprehensive  income  of  foreign 
operations into sterling.  The currency that gave rise to 
this risk in 2020 was primarily from realised US dollars 
transactions. The foreign exchange loss recorded during 
2020  was  £454k  (2019:  £41k)  which  is  composed  of 
realised and unrealised gains/losses. 
Basic and diluted earnings per share calculated on an 
adjusted basis were 20.4p and 19.1p respectively (2019: 
19.3p  basic  and  18.4p  diluted).  The  reported  basic 
and  diluted  earnings  per  share  were  12.7p  and  11.9p 
respectively (2019: (5.7)p basic and (5.7)p diluted). 
The  period  saw  strong  net  cash  generated  from 
operating activities of £6.9m (2019: £5.4m), largely due 
to cash inflow from key contracts, outsourced services, 
working  capital  management  and  a  £0.7m  tax  credit 
claimed  across  the  Group.    In  July  2020  the  Group 
successfully  raised  equity  funds  from  institutional 
investors amounting to £15.0m, net of expenses, for the 
purpose of funding its M&A strategy. As a result of this 
cash injection and the positive organic cash generation 
achieved in the year, cash balances increased to £26.7m 
at  31  December  2020,  compared  with  £6.0m  as  at  31 
December 2019. 
Following  the  reporting  period  end  the  Group 
completed  the  acquisition  of  The  Edge  Software 
Consultancy  Ltd.    (‘The  Edge’)  in  March  2021.  The 
acquisition  extends  the  Group  into  early  stage  drug 
Discovery,  with  software  products  that 
improve 
customer  productivity  and  ensure  high-quality  data 
capture in the laboratory. Total consideration payable 
for The Edge is up to £8.5m with initial consideration of 
£6.0m satisfied by £4.0m in cash from the equity funds 
raised in 2020 and £2.0m via the issuance of 391,920 
new ordinary shares of 10p each in Instem plc, £0.5m 
of  deferred  consideration  and  up  to  a  further  £2.0m 
payable contingent on The Edge’s trading performance 
in the year ending 31 December 2021. 
On  20  March  2021,  Instem  exchanged  contracts  to 
acquire US-based clinical trial technology & consulting 
leader  d-Wise  Technologies,  Inc  (“d-wise”).  The 
acquisition was completed on 1 April 2021. d-wise adds 
a market leading position to the Group in an attractive 
adjacent area of clinical trial analysis and submission, 
with good future visibility through recurring revenue 
streams and already contracted, high value consultancy 
projects.  The  combined  strength  of  Instem  and 

1 7

S T R A T E G I C   R E P O R T   ( C O N T I N U E D )

The table below provides the data for certain performance measures mentioned above:

Annual support fees 

SaaS subscription and support fees

2020
£000

8,917

8,024

2019
£000

8,418

6,444

Recurring revenue

16,941

14,862     

Licence fees

Professional services

Technology enabled outsourced services

3,477

1,603

6,196

Total revenue

28,217

EBITDA

Non recurring costs (see note 3)

*Adjusted EBITDA

Profit/(Loss) before tax

Amortisation of intangibles arising on acquisition

Impairment of goodwill and capitalised development

Non recurring costs (see note 3)

Intercompany foreign exchange loss/(gain)

**Adjusted profit before tax

Weighted average number of shares (000's)

Adjusted diluted earnings per share 

Cash at bank

Bank overdraft

Cash balance

5,313

606

5,919

2,549

664

-

606

208

4,027

19,652

19.4p

35,722

(8,998)

26,724

3,501

1,773

5,581

25,717

4,562

302

4,864

(901)

523

3,175

302

61

3,160

17,053

18.4p

14,955

(8,998)

5,957

* Earnings before interest, tax, depreciation, amortisation, impairment of goodwill and capitalised development 
costs plus non-recurring costs.
**After adjusting for the effect of foreign currency exchange on the revaluation of inter-company balances included 
in finance income/(costs), non-recurring items, impairment of goodwill and capitalised development costs plus 
amortisation of intangibles on acquisitions. 

1 8

U P D A T E   O N   H I S T O R I C A L 
C O N T R A C T   D I S P U T E

An  historical  contractual  licence  dispute,  which  does 
not  affect  the  ongoing  operations  of  the  Group,  is  in 
the process of being heard by the German courts. The 
Group is defending the action and strongly believes that 
the  claim  should  be  dismissed.  Notwithstanding  this, 
the cost provision made in 2017 has been maintained in 
the 2020 financial statements. Further announcements 
will be made as and when appropriate. To date all legal 
expenses have been expensed.

P R I N C I P A L   R I S K S   A N D 
U N C E R T A I N T I E S

The directors consider that the global pharmaceutical 
market  is  likely  to  continue  to  provide  growth 
opportunities for the business. The combination of the 
high  level  of  annual  support  renewals  and  low  levels 
of  customer  attrition  provides  revenue  visibility  to 
underpin  the  Group  strategy  on  product  and  market 
development.  However,  the  Group’s  products  may  be 
adversely affected if economic and market conditions 
are unfavourable and revenue may be affected from by 
impact of accounting or regulatory changes.
Additionally, weak economic conditions, including the 
potential impact of the trading arrangements between 
the UK and EU at the end of the Brexit transition period 
in December 2020 may affect the future performance 
of  the  Group  and  its  clients.    One  area  of  mitigation 
for  the  Group  is  the  presence  of  its  wholly  owned 
subsidiary, Notocord SA, which is based in the EU.
The  Group  seeks  to  mitigate  exposure  to  all  forms  of 
risk  through  a  combination  of  regular  performance 
review  and  a  comprehensive  insurance  programme 
Additionally,  the  Group  has  a  significant  proportion 
of recurring revenue (circa 60% of total) from annual 
support & maintenance and SaaS contracts from a well-
established  global  customer  base.    Consequently,  the 
Group ensures that it maintains a diversified portfolio 
in  terms  of  customers,    revenue  mix,  geography  and 
markets.

Foreign currency risk
The Group operates internationally and is exposed to 
foreign currency risk on transactions denominated in 
a currency other than the functional currency and on 
the  translation  of  the  statement  of  financial  position 
and  statement  of  comprehensive  income  of  foreign 
operations  into  sterling.    The  main  currency  giving 
rise to this risk is US dollars.  The Group mitigates the 
foreign currency risk by having both cash inflows and 
outflows in the relevant foreign currency due to local 

revenue generation generally offset by a local cost base 
that creates a natural hedge. 
The Group also generates material cash reserves through 
its Chinese subsidiary that are not readily available to 
the UK Group at short notice and, as such, the Group 
has  to  maintain  sufficient  working  capital  headroom 
to accommodate any delays in repatriating cash from 
China. In managing currency risks the Group aims to 
reduce  the  impact  of  short-term  fluctuations  on  the 
Group’s cash inflows and outflows in a foreign currency. 
The  Group  continually  assesses  the  most  appropriate 
approach  to  managing  its  currency  exposure  in  line 
with the overall goal of achieving predictable earnings 
growth.  Over  the  longer  term,  changes  in  foreign 
exchange  could  have  an  impact  on  consolidation  of 
foreign  subsidiaries  earnings.    A  10%  decrease  in  the 
average  value  of  Sterling  against  the  US  dollar  would 
have resulted in an increase in the Group’s profit before 
tax  by approximately £0.1m (2019: £0.1m).

Credit risk
Management aims to minimise the risk of credit losses.
The Group’s financial assets are bank balances and cash 
and  trade  and  other  receivables,  which  represent  the 
Group’s maximum exposure to credit risk in relation to 
financial assets.
The  Group’s  credit  risk  is  primarily  attributable  to  its 
trade  receivables  and  the  Group  has  policies  in  place 
to ensure that sales of products and services are made 
to  customers  with  appropriate  creditworthiness.  No 
customer  individually  amounts  to  more  than  10%  of 
the  Group  revenue.  At  the  2020  year  end  the  Group 
had a maximum credit risk exposure of £6.1m (2019: 
£6.9m).
The  amounts  presented  in  the  statement  of  financial 
position are net of impairment provisions.
The  Group’s  exposure  to  losses  from  defaults  on 
trade  receivables  is  reduced  due  to  contractual  terms 
which  require  installation,  training,  annual  licensing 
and  support  fees  to  be  invoiced  and  paid  annually  in 
advance.
Note  15  sets  out  the  impairment  provision  for  credit 
losses  on  trade  receivables  and  the  ageing  analysis  of 
overdue trade receivables. There were no impairment 
losses recognised on other financial assets.

Liquidity risk
Liquidity risk is the risk that the Group will not be able 
to meet its financial commitments as they fall due. The 
Group’s objective is to ensure that adequate facilities are 
available through use of bank overdrafts and leases.  The 
Group manages liquidity risk through regular cash flow 
forecasting and monitoring of cash flows, management 

1 9

S T R A T E G I C   R E P O R T   ( C O N T I N U E D )

review and regular review of working capital and costs. 
The Group regularly monitors its available headroom 
under  its  borrowing  facilities.  At  31  December  2020, 
its £0.5m net bank facility was undrawn (2019: £0.5m 
undrawn).  The  Group  had  positive  cash  reserves  of 
£26.7m  at  the  end  of  the  Period,  in  addition  to  the 
£0.5m  undrawn  working  capital  facility,  although 
£2.5m of the cash was held in bank accounts in China, 
where  it  has  been  traditionally  harder  to  repatriate 
funds quickly. There are no long-term restrictions on 
the transfer of funds from the Group bank accounts in 
China.  Since  the  year-end  the  Group  has  repatriated 
£1.6m of cash from China to the UK.

Interest rate risk 
The  Group  operates  an  interest  rate  policy  designed 
to  minimise  interest  costs  and  reduce  volatility  in 
reported earnings. The Group’s bank facility does not 
allow the US Dollar cash balances to generate interest 
therefore the Group transfers funds from the US dollar 
account into the sterling account.  Currency transfers 
have been utilised to maximise the interest gains whilst 
minimising foreign exchange risks. As at 31 December 
2020, the indications are that the UK bank base interest 
rate will not materially differ over the next 12 months.  
On the basis of the net cash position at 31 December 
2020  and  assuming  no  other  changes  occur  (such 
as  material  changes  in  currency  exchange  rates)  the 
change in interest rates will not have a material impact 
on net interest income/(expense). 

Cyber risk 
The  Group  handles  much  data  electronically  and  is 
therefore  extremely  aware  of  the  risks  that  a  cyber-
attack could have on its business. It has robust standards 
in place for establishing and maintaining systems and 
processes to ensure that the highest standards of data 
protection  are  in  place.  This  also  applies  to  any  third 
party who is handling data on behalf of the Group and 
its customers, such as third-party hosting providers. 

Technology risk
Due  to  the  evolving  nature  of  technology  platforms 
there  is  a  risk  of  obsolescence.  The  Group’s  future 
performance  depends  on  software  development,  by 
introducing new and enhancing new products to meet 
customer  demand.  If  the  Group  does  not  respond 
effectively  to  technological  changes,  changes  in  client 
requirements and regulatory industry changes then its 
business may be negatively affected.

The  Group  monitors  this  risk  and  develops  strategic 
development  plans  to  ensure  it  remains  compliant 
with  technological  advances.  Additionally,  the  Group 
produces  roadmaps  for  its  key  software  products 
through 
its  close  relationships  with  clients  and 
partners. In addition, the Group reviews forthcoming 
regulations  to  identify  any  need  to  change  existing 
products and to identify opportunities for developing 
new products and services.

Acquisition risk
Any  corporate  acquisition  has  associated  integration 
risk. In respect of every acquisition the Group creates 
an integration plan with assigned responsibilities to a 
team led by an appointed project manager for delivering 
against an agreed timetable. This is monitored closely 
throughout the integration process and any deviations 
against the plan are flagged and actioned accordingly. 
Acquisitions  are  carefully  assessed  by  the  Board 
to  ensure  alignment  with  the  Group’s  acquisition 
strategy. The Group performs thorough due diligence, 
supported by the appropriate use of external advisers, 
to  help  identify  any  unexpected  material  adverse 
consequences prior to deal completion.

Recruitment and retention risk
As its people are the Group’s major asset, it is critical 
to  ensure  that  it  recruits  the  best  staff  possible  and 
that  these  individuals  are  rewarded  and  developed 
appropriately.  If  the  Group  is  unable  to  attract  and 
retain  qualified  personnel  it  is  unlikeyly  to  meet  its 
growth  objectives  and  stakeholder  expectations.  The 
Group has a global HR team that manages the process 
of  ensuring  the  staff  benefit  and  reward  packages 
are  incentivising  for  both  recruitment  and  retention 
purposes.  This  includes  benchmarking  against  peers 
and  industry  norms  and  considering  staff  feedback 
through regular performance review. During 2020 the 
Group  implemented  an  all-staff  share  scheme  for  the 
first time.

COVID-19
The  risk  to  the  Group,  as  for  any  business,  is  that 
the  COVID-19  pandemic  impacts  new  and  existing 
business  activities  as  clients  and  suppliers  focus  on 
short term priorities arising from pandemic or struggle 
to remain in business.
The Group remains well placed and has seen minimal 
impact  from  COVID-19,  with  working  from  home 
practices  implemented  and  the  majority  of  business 

2 0

P J Reason
Chief Executive
10 April 2021

relatively  unaffected.  There  was  a  small  shortfall  in 
Professional  Services  revenue  compared  with  budget  
due  to  travel  restrictions  preventing  on-site  service 
delivery plus Academia was closed for part of the year. 
It is expected that a small element of revenue slippage 
will move into the current year as we fulfil our strong 
services backlog.

P O S T   P E R I O D - E N D

The  Group  completed 
the  earnings  enhancing 
acquisitions of The Edge and d-wise. The Edge, which 
was acquired for up to £8.5m, is a discovery software 
solutions provider with an established client base across 
the pharmaceutical, biotechnology, biopharmaceutical 
and animal health sectors. Its addition further broadens 
Instem's  reach  into  the  closely  adjacent  Discovery 
Study Management market.
d-wise,  which  is  a  US-based  clinical  trial  technology 
&  consulting  leader,  was  acquired  for  up  to  $31.0m. 
The  d-wise  team  and  its  solutions  will  create  a  new 
operating segment at Instem, Clinical Trial Acceleration 
Solutions, which will focus on leveraging the combined 
capabilities to further expand areas of application.

O U T L O O K

The  performance  during  the  Period  highlighted  our 
resilience – especially given the COVID-19 backdrop. 
Our  proven  model  continues  to  generate  strong  cash 
flows while the combination of increasing demand for 
regulatory-backed solutions and a growing demand for 
artificial intelligence and in silico solutions in the drug 
discovery process underpin our confidence in further 
leveraging our product base. 
We  are  extremely  pleased  with  our  continued  strong 
organic  growth  and  increasing  ability  to  cross  sell  to 
existing and new clients. Furthermore, we are primed 
to build on this momentum, having strengthened our 
proposition  post period end.  The  recent  acquisitions 
of  d-wise  and  The  Edge  highlight  our  ability  to  add 
scale and leverage existing customer relationships with 
a view to further enhancing earnings and profitability, 
while  providing  a  strong  cornerstone  for  continued 
growth.  In  addition,  we  are  continuing  discussions 
with a number of other potential acquisition targets.
Given  the  structural  backdrop  and  opportunities 
within  our  existing  client  base  we  are  confident  that 
we  are  well  placed  to  continue  growing  recurring 
revenues,  margins,  and  cash  generation,  and  look 
forward to augmenting organic growth via our ongoing 
acquisition strategy.

2 1

B O A R D   O F   D I R E C T O R S

Non-executive Chairman

Chief Executive Officer

D a v i d   G a r e

P h i l   R e a s o n

David was a founder member 
of the Company’s former 
parent, Instem Limited, and 
led the resulting businesses 
through most of their history. 
David successfully achieved 
a succession of strategic 
developments for Instem 
Limited, including its sale to 
Kratos Inc. in 1976, its MBO in 
1983, its flotation on the USM 
in 1984, its flotation on the 
Official List in 1996, its public 
to private and demerger in 
1998 and the buyout of Instem 
LSS Limited from Alchemy 
Partners in 2002. Throughout, 
David has concentrated 
on value creation through 
achievement of a strong market 
position. 

Phil is an experienced chief 
executive who has developed 
a number of IT businesses in 
the life sciences and nuclear 
industries, both organically 
and through acquisition. 
Phil joined the former parent 
Company, Instem Limited, 
in 1982 and was appointed 
Managing Director of the 
Life Sciences division in 1995 
and Chief Executive Officer 
of Instem LSS Limited on the 
demerger from Instem Limited. 
Given the importance of the 
North American market to 
Instem’s organic and acquisitive 
growth, Phil relocated from 
the UK to the US in 2003 and 
established a new headquarters 
in the Philadelphia area. Phil 
previously ran Instem Limited’s 
Nuclear and Laboratory 
Information Management 
Systems integration businesses.

2 2

Chief Financial Officer

Non-executive Director

Non-executive Director

N i g e l   G o l d s m i t h

M i k e   M c G o u n

D a v i d   S h e r w i n

Mike has a wealth of 
management experience 
within the IT industry. He 
spent 10 years at IBM prior 
to co-founding a successful 
ComputerLand franchise 
in 1984. In 1994, Mike 
moved to SkillsGroup plc as 
a main board director, with 
responsibility for corporate 
development and later as a 
non-executive director. Mike 
was founder and non-executive 
Chairman of Tikit Group plc 
prior to its disposal to BT plc 
in 2012. 

David is a qualified 
Management Accountant 
and holds an MBA from 
Staffordshire University. He 
joined Instem Limited as a 
trainee accountant in 1973 and 
was appointed Chief Financial 
Officer in 1979. He has worked 
closely with David Gare on all 
of the subsequent transactions 
involving Instem Limited 
and Instem LSS Limited 
including participating in the 
management buyout of Instem 
Limited in 1983, the flotation 
on the USM in 1984, the 
flotation on the Official List in 
1996 and the demerger of the 
business in 1998.

Nigel, who joined Instem 
in November 2011, has a 
wealth of experience in senior 
financial roles, at both public 
and private companies within 
the pharmaceutical industry. 
After qualifying as a Chartered 
Accountant, Nigel spent over 
nine years at KPMG prior to 
moving into industry. Nigel 
was Finance Director for 
three years at AIM listed, 
pharmaceutical and medical 
device company, IS Pharma 
plc. He also spent a seven-year 
tenure as CFO at Almedica 
International Inc, a privately 
held supplier of clinical trial 
materials to the pharmaceutical 
and biotech industry in Europe 
and the US and two years as 
European Controller for the 
sales and marketing division 
of laboratory equipment 
manufacturer, Life Sciences 
International plc.

2 3

C O R P O R A T E   G O V E R N A N C E   S T A T E M E N T

and may meet at any other time as required by either 
the  chairman  of  the  Audit  Committee,  the  Chief 
Financial Officer of the Group or the external auditor 
of the Group.  In addition, the Audit Committee shall 
meet with the external auditor of the Group (without 
any of the executives attending) at any time during the 
year as it deems fit. 
The Audit Committee:
a.  monitors  the  financial  reporting  and  internal 

financial control principles of the Group;
b.  maintains  appropriate  relationships  with 
including  considering 

the 
the 
external  auditor 
appointment  and  remuneration  of  the  external 
auditor  and  reviews  and  monitors  the  external 
auditor’s  independence  and  objectivity  and  the 
effectiveness of the audit process;
reviews  all  financial  results  of  the  Group  and 
financial statements, including all announcements 
in respect thereof before submission of the relevant 
documents to the Board;

c. 

d.  reviews  and  discusses  (where  necessary)  any 
issues  and  recommendations  of  the  external 
auditor including reviewing the external auditor’s 
management letter and management's response;
e.  considers all major findings of internal operational 
audit  reviews  and  management's  response  to 
internal  and 
ensure  co-ordination  between 
external auditor;
reviews the Board's statement on internal reporting 
systems and keeps the effectiveness of such systems 
under review; and

f. 

g.  considers  all  other  relevant  findings  and  audit 

programmes of the Group.

The Audit Committee is authorised to:
investigate any activity within its terms of reference;
a. 
b.  seek any information it requires from any employee 

of the Group; and

c.  obtain,  at  the  Group’s  expense,  outside  legal  or 
other  independent  professional  advice  and  to 
secure the attendance of such persons to meetings 
as it considers necessary and appropriate.

In  accordance  with  AIM  Notice  50  issued  by  the 
London  Stock  Exchange,  8  March  2018,  the  Group 
has adopted the Corporate Governance Guidelines for 
Small and Medium Size Quoted Companies published 
by the Quoted Companies Alliance (the QCA Code).
The main features of the Group’s corporate governance 
procedures, in relation to the 10 Principles of the QCA 
Code, are set out in the full QCA Code Compliance at 
https://investors.instem.com/corporate/governance.
php.
As noted in the Organisational Governance section of 
the Strategic Report above. The Board seeks to maintain 
a strong governance ethos throughout the Group and is 
actively taking steps to address any shortcomings, such 
as the composition of the Board.  The Board recognises 
its  overall  responsibility  for  the  Group’s  systems  of 
internal control and for monitoring their effectiveness. 
The main features of the Group’s corporate governance 
procedures are as follows:
a. 

the  Board  has  one  independent  non-executive 
director who takes an active role in Board matters;
the Group has an Audit Committee, a Remuneration 
Committee  and  a  Nomination  Committee,  each 
of  which  consists  of  the  non-executive  directors, 
and  meets  regularly  with  executive  directors  in 
attendance  by  invitation.  The  Audit  Committee 
has unrestricted access to the Group's auditor and 
ensures  that  auditor  independence  has  not  been 
compromised;

b. 

c.  all  business  activity  is  organised  within  a  defined 
structure  with  formal  lines  of  responsibility  and 
delegation  of  authority,  including  a  schedule  of 
"matters referred to the Board"; and

d.  regular monitoring of key performance indicators 
together  with 
(KPIs)  and  financial 
comparison  of  these  against  expectations.  KPIs 
assessed are both financial and non-financial.

results 

A U D I T   C O M M I T T E E

The  Audit  Committee  comprises  M  F  McGoun 
(Chairman),  D  Gare  and  D  M  Sherwin,  all  of  whom 
are  non-executive  directors  of  the  Group.  The  Board 
is satisfied that the Audit Committee has all the recent 
and relevant financial experience required to fulfil the 
role. 
Appointments  to  the  Audit  Committee  are  made 
by  the  Board  in  consultation  with  the  Nomination 
Committee and the chairman of the Audit Committee.  
The Audit Committee  has met twice during the year 

2 4

A T T E N D A N C E   A T   B O A R D   A N D   C O M M I T T E E   M E E T I N G S 

Attendances of directors at Board and Committee meetings convened in the period, along with the number 
of meetings they were invited to attend, are set out below. Due to the closure of the UK head office during the 
pandemic, all meetings were held by remote video calls.

No. of meetings attended / No. of meetings invited to attend

Board Meetings

Audit Committee

Remuneration Committee

Nomination Committee

Executive Directors

P J Reason

N J Goldsmith

Non-Executive Directors

D Gare

D M Sherwin

M F McGoun

10/10

10/10

10/10

10/10

10/10

5/5

5/5

5/5

5/5

5/5

1/1

0/0

2/2

2/2

2/2

1/1

1/1

1/1

1/1

1/1

R E M U N E R A T I O N   C O M M I T T E E

The Remuneration Committee comprises M F McGoun 
(Chairman), D Gare and D M Sherwin, all of whom are 
non-executive directors of the Group.
The  members  of  the  Remuneration  Committee  are 
appointed  by  the  Board  on  recommendation  from 
the  Nomination  Committee,  in  consultation  with  the 
Chairman of the Remuneration Committee.  The Chief 
Executive Officer of the Group is normally invited to 
meetings  of  the  Remuneration  Committee  to  discuss 
the performance of other executive directors but is not 
involved  in  any  of  the  decisions.  The  Remuneration 
Committee  invites  any  person  it  thinks  appropriate 
to join the members of the Remuneration Committee 
at  its  meetings.  The  Remuneration  Committee  meets 
at least once a year and any other time as required by 
either the Chairman of the Remuneration Committee 
or the Chief Financial Officer of the Group.
The Remuneration Committee:
a.  ensures  that  the  executive  directors  are  fairly 
rewarded  for  their  individual  contributions  to 
the  overall  performance  of  the  Group  but  also 
ensures that the Group avoids paying more than is 
necessary for this purpose;

b.  considers  the  remuneration  packages  of  the 
executive  directors  and  any  recommendations 
made by the Chief Executive Officer for changes to 
their  remuneration  packages  including  in  respect 
of  bonuses  (including  associated  performance 
criteria),  other  benefits,  pension  arrangements 
and other terms of their service contracts and any 
other  matters  relating  to  the  remuneration  of  or 
terms  of  employment  applicable  to  the  executive 
directors that may be referred to the Remuneration 
Committee by the Board;

c.  oversees  and  reviews  all  aspects  of  the  Group’s 
share  option  schemes  including  the  selection  of 
eligible  directors  and  other  employees  and  the 
terms of any options granted;

d.  demonstrates to the Group’s shareholders that the 
remuneration of the executive directors is set by an 
independent committee of the Board; and

e.  considers  and  makes  recommendations  to  the 
Board  about  the  public  disclosure  of  information 
the  executive  directors'  remuneration 
about 
packages  and  structures  in  addition  to  those 
required by law or by the London Stock Exchange.
The  Chairman  of  the  Remuneration  Committee 
reports  formally  to  the  Board  on  its  proceedings 
after  each  meeting  on  all  matters  within  its  duties 
and  responsibilities.  The  Remuneration  Committee 
produces  an  annual  report  which  is  included  in  the 
Group’s annual report and accounts.
The Remuneration Committee is authorised to:
a. 
investigate any activity within its terms of reference;
b.  seek any information it requires from any employee 

of the Group;

c.  assess  the  remuneration  paid  by  other  UK  listed 
companies  of  a  similar  size  in  any  comparable 
industry sector and to assess whether changes to the 
executive  directors’  remuneration  is  appropriate 
for  the  purpose  of  making  their  remuneration 
competitive  or  otherwise  comparable  with  the 
remuneration paid by such companies; and

d.  obtain,  at  the  Group’s  expense,  outside  legal  or 
other  independent  professional  advice,  including 
independent  remuneration  consultants,  when  the 
Remuneration  Committee  reasonably  believes  it 
is necessary to do so and secure the attendance of 
such persons to meetings as it considers necessary 
and appropriate. 

2 5

C O R P O R A T E   G O V E R N A N C E   S T A T E M E N T   ( C O N T I N U E D )

N O M I N A T I O N   C O M M I T T E E

d. 

The  Nomination  Committee  comprises  D  Gare 
(Chairman),  M  F  McGoun  and  D  M  Sherwin,  all  of 
whom are non-executive directors of the Group.
Appointments to the Nomination Committee are made 
by the Board, in consultation with the Chairman of the 
Nomination Committee. 
The  Nomination  Committee  may  invite  any  person 
it  thinks  appropriate  to  join  the  members  of  the 
Nomination Committee at its meetings. 
The Nomination Committee:
a. 

reviews  the  structure,  size  and  composition 
(including  skills,  knowledge  and  experience) 
required  of  the  Board  compared  to  its  current 
position and makes recommendations to the Board 
with regard to any changes;

b.  gives full consideration to succession planning for 
directors and other senior executives in the course 
of its work, taking into account the challenges and 
opportunities facing the Group, and what skills and 
expertise are needed on the Board in the future;
is  responsible  for  identifying  and  nominating  for 
the approval of the Board, candidates to fill Board 
vacancies as and when they arise; and

c. 

d.  evaluates  the  balance  of  skills,  knowledge  and 
experience  on  the  Board  before  an  appointment 
is made and, in light of this evaluation, prepares a 
description of the role and capabilities required for 
a particular appointment.

the  Nomination  Committee 
The  Chairman  of 
reports formally to the Board on its proceedings after 
each  meeting  on  all  matters  within  its  duties  and 
responsibilities. 
The  Nomination 
recommendations to the Board concerning:
a. 

formulating plans for succession for both executive 
and non-executive directors and in particular the 
key  roles  of  Chairman  of  the  Board  and  Chief 
Executive Officer;

also  makes 

Committee 

c. 

b.  membership  of  the  Audit  and  Remuneration 
Committees, in consultation with the chairmen of 
those committees;
the re-appointment of any non-executive director 
at  the  conclusion  of  their  specified  term  of  office 
having given due regard to their performance and 
ability  to  continue  to  contribute  to  the  Board  in 
the  light  of  the  knowledge,  skills  and  experience 
required;

2 6

the  re-election  by  shareholders  of  any  director 
under  the  “retirement  by  rotation”  provisions  in 
the  Company’s  articles  of  association  having  due 
regard to their performance and ability to continue 
to  contribute  to  the  Board  in  the  light  of  the 
knowledge, skills and experience required;

e.  matters relating to the continuation in office of any 
director  at  any  time  including  the  suspension  or 
termination of service of an executive director as 
an employee of the Group subject to the provisions 
of the law and his/her service contract; and
the  appointment  of  any  director  to  executive  or 
other office other than to the positions of Chairman 
of  the  Board  and  Chief  Executive  Officer,  the 
recommendation  for  which  would  be  considered 
at a meeting of the full Board.

f. 

legal  or  other 

The Nomination Committee is authorised to:
a. 
investigate any activity within its terms of reference;
b.  seek any information it requires from any employee;
independent 
c.  obtain  outside 
professional  advice  at  the  Group’s  expense  when 
the Nomination Committee reasonably believes it 
is necessary to do so; and
instruct external professional advisors to attend any 
meeting at the Group’s expense if the Nomination 
Committee  considers  this  reasonably  necessary 
and appropriate. 

d. 

I N T E R N A L   C O N T R O L S

The  directors  are  responsible  for  establishing  and 
maintaining  the  Group’s  system  of  internal  control 
and reviewing its effectiveness. The system of internal 
control  is  designed  to  manage  rather  than  eliminate 
the  risk  of  failure  to  achieve  business  objectives  and 
can only provide reasonable but not absolute assurance 
against material misstatement or loss.
The Board and senior executives meet to review both 
the risks facing the business and the controls established 
to  minimise  those  risks  and  their  effectiveness  in 
operation on an ongoing basis. The aim of these reviews 
is  to  provide  reasonable  assurance  that  material  risks 
and  problems  are  identified  and  appropriate  action 
taken at an early stage.

On behalf of the Board

M F McGoun
Independent Non-Executive Director

T h e   B o a r d 

r e c o g n i s e s 

i t s   o v e r a l l 

r e s p o n s i b i l i t y 

f o r   t h e   G r o u p ’ s 

s y s t e m s   o f 

i n t e r n a l 

c o n t r o l   a n d   f o r 

m o n i t o r i n g   t h e i r 

e f f e c t i v e n e s s . 

C o r p o r a t e   G o v e r n a n c e   S t a t e m e n t

2 7

D I R E C T O R S ’   R E M U N E R A T I O N   R E P O R T

Instem  plc  is  a  company  listed  on  AIM  and  it  is  not 
required to comply with Schedule 8 of the Large and 
Medium  Sized  Companies  and  Groups  (Accounts 
and  Reports)  Regulations  2008  relating  to  directors’ 
remuneration  reports  or  the  Listing  Rules.    The 
disclosures contained within this report are, therefore, 
made  on  a  voluntary  basis  and  in  keeping  with  the 
Board’s commitment to best practice.

R E M U N E R A T I O N   C O M M I T T E E

The  Remuneration  Committee  (‘the  Committee’)  is 
composed  entirely  of  non-executive  directors.  The 
Committee was formed upon the public listing of the 
Company on 13 October 2010.  The Chairman of the 
Committee is M F McGoun.  The terms of reference for 
the Committee are to determine the Group’s policy on 
executive  remuneration  and  to  consider  and  approve 
the  remuneration  packages  for  directors  and  key 
executives of the Group, subject to ratification by the 
Board.    During  the  year,  the  Committee  met  on  two 
occasions.  Full details of the elements of each director’s 
remuneration are set out on the following page.  Details 
of  share-based  payment  are  shown  in  note  9  to  the 
financial statements.

P O L I C Y   O N   E X E C U T I V E 
D I R E C T O R   R E M U N E R A T I O N

The  Group’s  current  and  ongoing  policy  aims  to 
ensure  that  executive  directors  are  rewarded  fairly 
for  their  individual  contributions  to  the  Group’s 
overall performance and is designed to attract, retain 
and  motivate  executives  of  the  right  calibre.    The 
Committee  is  responsible  for  recommendations  on 
all  elements  of  executive  remuneration  including,  in 
particular,  basic  salary,  annual  bonus,  share  options 
and  any  other  incentive  awards.    In  implementing 
the  remuneration  policy,  the  Committee  has  regard 
to  factors  specific  to  the  Group,  such  as  salary  and 
other benefit arrangements within the Group and the 
achievement  of  the  Group’s  strategic  objectives.    The 
Committee determines the Group’s Policy on executive 
remuneration with reference to comparable companies 
of similar market capitalisation, location and business 
sector.

B A S I C   S A L A R Y

The  basic  salaries  of  executive  directors  are  reviewed 
annually  having  regard  to  individual  performance 
and position within the Group and are intended to be 
competitive but fair using information provided from 
both internal and external sources.

P E R F O R M A N C E   R E L A T E D 
A N N U A L   B O N U S

Executive directors are eligible for a performance related 
bonus  based  on  Group  performance,  in  particular, 
the  achievement  of  profit  targets.    The  performance 
related  annual  bonus  forms  a  significant  part  of  the 
level  of  remuneration  considered  appropriate  by  the 
Committee.  In addition to the formal bonus scheme, 
the  Committee  has  the  discretion  to  recommend 
the  payment  of  ad  hoc  awards  to  reflect  exceptional 
performance.  Cash  bonuses  amounting  to  £18,000 
were  payable  to  executive  directors  in  respect  of  the 
year ended 31 December 2020 (2019: £nil).

P E N S I O N S

Company  contributions  are  made  to  the  executive 
directors’ personal pension schemes up to a maximum 
of 16.5% of basic salary.

B E N E F I T S

Benefits  comprise  car  and  fuel  allowance,  private 
healthcare  and  critical  illness  cover.  No  executive 
director  receives  additional  remuneration  or  benefits 
in relation to being a director of the Board of the Group 
or any subsidiary of the Group.

S E R V I C E   C O N T R A C T S

The  Executive  directors  have  contracts  with  notice 
periods between six and twelve months.
The  Board  determines  the  Group’s  policy  on  non-
executive directors’ remuneration.
D  Gare,  D  M  Sherwin  and  M  F  McGoun  each  have 
a  letter  of  appointment  with  a  notice  period  of  three 
months.  

2 8

The emoluments paid or payable to directors in respect of the year ended 31 December 2020 were as follows:

Salary and Fees

Bonus

Benefits

Pension

2020 Total

2019 Total

Executives

P J Reason*

N J Goldsmith

Non-executives

D Gare

D M Sherwin

M F McGoun

226

128

65

33

40

Total

492

11

7

-

-

-

18

8

5

-

-

-

13

31

13

-

-

-

44

276

153

65

33

40

567

261

141

60

30

30

522

* The remuneration in respect of P J Reason is payable in US Dollars and translated at the average rates as disclosed on page 57. 
The total remuneration paid in the year was USD 355,000 (2019: USD 332,000).

D I R E C T O R S ’   A N D   E M P L O Y E E S ’   S H A R E   O P T I O N S

Exercise price 
(£)

Issue date

Held at 31 
Dec 2019

Granted 
during year

Exercised 
during year

Lapsed 
during year

Held at 31 
Dec 2020

P J Reason
Ordinary shares

N J Goldsmith
Ordinary shares

Employees
Ordinary shares

1.750
0.900
Nil
Nil

1.760
0.900
0.100
Nil
Nil

1.750
2.220
0.900
0.100
0.100
0.100
0.100
0.100
Nil
0.100
Nil
Nil
Nil

13/10/2010
14/01/2013
22/02/2018
26/06/2020

07/02/2012
14/01/2013
29/07/2015
22/02/2018
26/06/2020

13/10/2010
17/10/2011
14/01/2013
11/02/2015
29/07/2015
21/11/2015
27/05/2016
03/05/2017
22/02/2018
22/02/2019
27/04/2020
06/05/2020
19/05/2020

187,427
23,429
80,000
-

20,000
15,000
62,500
80,000
-

50,714
8,667
22,975
40,584
78,125
25,258
6,480
37,500
240,000
4,644
-
-
-

-
-
-
76,000

-
-
-
-
74,000

-
-
-
-
-
-
-
-
-
-
118,728
24,000
243,000

(187,427)
-
-
-

-
-
-
-
-

(50,714)
-
-
-
-
-
-
-
-
-
-
-
-

-
-
-
-

-
-
-
-
-

-
-
-
-
-
-
-
(15,000)
-
(4,644)
(2,144)
-
-

-
23,429
80,000
76,000

179,429

20,000
15,000
62,500
80,000
74,000

251,500

-
8,667
22,975
40,584
78,125
25,258
6,480
22,500
240,000
-
116,584
24,000
243,000

828,173

Total

983,303

535,728

(238,141)

(21,788)

1,259,102

Approved by the Board and signed on its behalf by:

M F McGoun

Independent Non-Executive Director

2 9

D I R E C T O R S '   R E P O R T

The  directors  submit  their  report  and  the  Group  and 
Company  financial  statements  of  Instem  plc  for  the 
year ended 31 December 2020.
Instem  plc  is  a  public  limited  company,  incorporated 
and domiciled in England, and quoted on AIM.

D I R E C T O R S ’   R E S P O N S I B I L I T Y 
U N D E R   S E C T I O N   1 7 2

The  Group’s  response  to  the  requirements  of  section 
172 of the Companies Act 2006 is included within the 
Strategic Report.

P R I N C I P A L   A C T I V I T I E S

Instem  is  a  leading  supplier  of  IT  applications  to  the 
life sciences healthcare market, delivering compelling 
solutions for data collection, management and analysis 
across  the  R&D  continuum.  Instem  applications  are 
in  use  by  customers  worldwide,  meeting  the  rapidly 
expanding  needs  of 
life  science  and  healthcare 
organisations for data-driven decision making leading 
to safer, more effective products.
Instem's portfolio of software solutions increases client 
productivity  by  automating  study-related  processes 
while  offering  the  unique  ability  to  generate  new 
knowledge through the extraction and harmonisation 
of actionable scientific information.

R E V I E W   O F   T H E   B U S I N E S S 

A detailed review of the development and performance 
of the Group’s business during the year and its position 
at  the  end  of  the  year  is  set  out  in  the  Chairman’s 
Statement and the Strategic Report on pages 10 to 21.

S T R A T E G I C   R E P O R T

The Group has chosen in accordance with Companies 
Act 2006, section 414C (11) to set out in the Group's 
strategic report on pages 10 to 21 information required 
to be contained in the Directors’ Report by Large and 
Medium-sized Companies and Groups (Accounts and 
Reports)  Regulations  2008,  Sch.  7,  where  not  already 
disclosed in the Directors’ Report.

B U S I N E S S   R E L A T I O N S H I P S 
W I T H   S U P P L I E R S ,   C U S T O M E R S 
A N D   O T H E R S

The  Groups’  response  to  the  requrirment  of  the 
business  relationship  with  suppliers,  customers  and 
others is included within the Section 172 Statement on 
page 13 to 15.

D I R E C T O R S ’   R E S P O N S I B I L I T Y 
U N D E R   G R E E N   H O U S E   G A S 
E M I S S I O N S   A N D   E N E R G Y 
C O N S U M P T I O N

The  Group  has  reviewed  the  requirements  of  the 
each 
Environmental  Reporting  guidelines, 
Company in the group that qualifies as large their total 
energy  consumption  is  below  40MWh  and  therefore 
the Group and Company is not required to prepare an 
Energy and Carbon Report.

for 

F U T U R E   D E V E L O P M E N T S

The  directors  consider  that  the  continued  investment 
in  product  and  market  development  will  allow  the 
business  to  grow  organically  in  its  core  markets. 
Investment  in  business  growth  initiatives  will  also 
allow  the  business  to  move  into  new  product  and 
market areas. The combination of organic growth along 
with  strategic  acquisitions  will  support  the  expected 
growth  as  outlined  in  the  Chairman’s  Statement  and 
the Strategic Report.
Like most businesses worldwide the Group continues 
to deal with the impact of COVID-19, with its primary 
concern being for the safety and wellbeing of its staff and 
their families. The Group has the benefit of operating 
in  a  sector  where  significant  worldwide  focus  is  on 
identifying vaccines and therapies for COVID-19, with 
a  number  of  our  customers  directly  involved  in  this 
work.  While  the  Group  experienced  some  disruption 
to demand for its products and services during the year 
there  were  also  some  increases  in  customer  demand.  
Whilst  approximately  half  of  the  Group’s  revenues 
are  generated  from  North  America,  the  remaining 
revenues are spread across the world and so there is no 
dependence  on  one  territory  thus  spreading  the  risk. 
The Group benefits from having no supply chain and 
no distribution network to rely on and has the added 
benefit  of  having  systems  and  processes  established 
to enable its workforce to work effectively from home 
across all of its sites worldwide. 

3 0

D I R E C T O R S ’   R E P O R T   ( C O N T I N U E D )

The uncertainty as to the future impact on the Group 
of the recent COVID-19 outbreak has been considered 
as  part  of  the  Group’s  adoption  of  the  going  concern 
basis.  Thus  far  we  have  not  observed  any  material 
impact on our overall existing business or in the level 
of new business opportunities that are being presented 
to  us  in  the  markets  in  which  we  operate.  We  saw  a 
little  slippage  in  customers  placing  new  business 
during  the  first  quarter  of  2020,  but  we  believe  this 
is unlikely to be a long term issue but instead caused 
whilst our customers were focused on managing their 
own  businesses,  with  changes  from  introducing  staff 
self-isolation and working from home. 
The  Group  cash  balance  at  the  year  end  included 
£0.9m ($1.1m) of US government Paycheck Protection 
Program loans received during the year. It is expected 
that these will be forgiven during 2021.

E V E N T S   A F T E R   T H E 
R E P O R T I N G   P E R I O D

The events occurred after the balance sheet date were 
disclosed in accordance with IAS 10, ‘Events after the 
reporting period’. Details are provided in note 31 to the 
Consolidated Financial Statements. 

R E S E A R C H   A N D   D E V E L O P M E N T 
A C T I V I T I E S

The  Group  continues  its  development  programme 
of  software  for  the  global  pharmaceutical  market 
including  the  research  and  development  of  new 
products  and  enhancement  to  existing  products.  The 
directors  consider  the  investment  in  research  and 
development  to  be  fundamental  to  the  success  of  the 
business in the future.

D I V I D E N D S

The  directors  do  not  recommend  the  payment  of  a 
dividend.

D I R E C T O R S

The following directors held office during the year:
D Gare
M F McGoun
D M Sherwin
P J Reason
N J Goldsmith 

Details  of  the  directors’  service  contracts  and  their 
respective  notice  terms  are  detailed  in  the  Directors’ 
Remuneration report on pages 28 to 29. 

D I R E C T O R S   A N D   T H E I R 
I N T E R E S T S

The  interests  of  the  directors  who  held  office  at  31 
December  2020  (2019:  as  at  3  June  2020)  were  as 
follows:

2020
No. of Shares

2019
No. of Shares

DG 2008 Discretionary 
Settlement

538,427

578,427

D M Sherwin

750,000

1,180,066

P J Reason

730,714

685,287

M F McGoun

N J Goldsmith

-

-

-

-

Directors’ interests in share options are detailed in the 
Remuneration report on pages 28 to 29 .

P O L I T I C A L   D O N A T I O N S

The  Group  made  no  political  donations  in  2020  or 
2019.

F I N A N C I A L   I N S T R U M E N T S

The  Group’s  objectives  and  policies  on  financial 
instruments  are  set  out  in  note  20  to  the  financial 
statements.

I N D E M N I T Y   O F   O F F I C E R S   A N D 
D I R E C T O R S

Under  the  Company’s  Articles  of  Association  and 
subject  to  the  provisions  of  the  Companies  Act,  the 
Group may and has indemnified all directors and other 
officers  against  liability  incurred  in  the  execution  or 
discharge of their duties or the exercise of their powers, 
including but not limited to any liability for the costs of 
any  legal  proceedings.  The  Group  has  purchased  and 
maintains  appropriate  insurance  cover  against  legal 
action brought against directors or officers.

3 1

D I R E C T O R S ’   R E P O R T   ( C O N T I N U E D )

A N N U A L   G E N E R A L   M E E T I N G

The Annual General Meeting (‘AGM’) of the Company 
will  be  held  on  27  May  2021.  The  resolutions  to  be 
proposed at the AGM, together with explanatory notes, 
appear in a separate notice of AGM which is sent to all 
shareholders. A proxy card for registered shareholders 
is distributed along with the notice.

A U D I T O R S   A N D   D I S C L O S U R E 
O F   I N F O R M A T I O N   T O   A U D I T O R

Pursuant  to  s489  of  the  Companies  Act  2006,  a 
resolution  to  re-appoint  Grant  Thornton  as  auditor 
will be put to the members at the forthcoming Annual 
General Meeting.

On behalf of the Board

P J Reason
Director 
10 April 2021

3 2

D I R E C T O R S ’   R E S P O N S I B I L I T Y   S T A T E M E N T

The directors are responsible for the maintenance and 
integrity  of  the  corporate  and  financial  information 
included  on  the  company’s  website.  Legislation  in 
the  United  Kingdom  governing  the  preparation  and 
dissemination of financial statements may differ from 
legislation in other jurisdictions. 

The  directors  are  responsible  for  preparing  the 
Strategic Report and Directors’ Report, the Directors’ 
Remuneration Report and the financial statements in 
accordance with applicable law and regulations.
law  requires  the  directors  to  prepare 
Company 
financial  statements  for  each  financial  year.  Under 
that  law  the  directors  have  elected  to  prepare  the 
financial  statements  in  accordance  with  International 
Accounting  Standards  (IAS)  in  conformity.  Under 
company  law  the  directors  must  not  approve  the 
financial statements unless they are satisfied that they 
give a true and fair view of the state of affairs and profit 
or  loss  of  the  company  and  group  for  that  period.  In 
preparing these financial statements, the directors are 
required to:
• 

select suitable accounting policies and then apply 
them consistently;

•  make  judgements  and  accounting  estimates  that 

• 

are reasonable and prudent;
state whether applicable International Accounting 
Standards (IAS) in conformity  have been followed, 
subject  to  any  material  departures  disclosed  and 
explained in the financial statements;

•  prepare  the  financial  statements  on  the  going 
concern basis unless it is inappropriate to presume 
that the company will continue in business.

The  directors  are  responsible  for  keeping  adequate 
accounting  records  that  are  sufficient  to  show  and 
explain  the  company’s  transactions  and  disclose  with 
reasonable accuracy at any time the financial position 
of  the  company  and  enable  them  to  ensure  that  the 
financial statements and the Directors’ Remuneration 
report  comply  with  the  Companies  Act  2006.  They 
are  also  responsible  for  safeguarding  the  assets  of 
the  company  and  hence  for  taking  reasonable  steps 
for  the  prevention  and  detection  of  fraud  and  other 
irregularities.
The directors confirm that: 
• 

so far as each director is aware, there is no relevant 
audit information of which the company’s auditor 
is unaware; and
the  directors  have  taken  all  the  steps  that  they 
ought to have taken as directors in order to make 
themselves aware of any relevant audit information 
and to establish that the company’s auditor is aware 
of that information.

• 

3 3

I N D E P E N D E N T   A U D I T O R ’ S   R E P O R T
T O   T H E   M E M B E R S   O F   I N S T E M   P L C 

FRC’s Ethical Standard as applied to listed entities, and 
we  have  fulfilled  our  other  ethical  responsibilities  in 
accordance  with  these  requirements.  We  believe  that 
the  audit  evidence  we  have  obtained  is  sufficient  and 
appropriate to provide a basis for our opinion.

C O N C L U S I O N S   R E L A T I N G   T O 
G O I N G   C O N C E R N 

are 

responsible 

concluding  on 

the    
for 
We 
appropriateness  of  the  directors’  use  of  the  going 
concern  basis  of  accounting  and,  based  on  the  audit 
evidence obtained, whether a material uncertainty exists 
related to events or conditions that may cast significant 
doubt on the group’s and the parent company’s ability 
to continue as a going concern. If we conclude that a 
material  uncertainty  exists,  we  are  required  to  draw 
attention  in  our  report  to  the  related  disclosures  in 
the  financial  statements  or,  if  such  disclosures  are 
inadequate,  to  modify  the  auditor’s  opinion.  Our 
conclusions are based on the audit evidence obtained 
up to the date of our report. However, future events or 
conditions may cause the group or the parent company 
to cease to continue as a going concern.
A  description  of  our  evaluation  of  management’s 
assessment of the ability to continue to adopt the going 
concern  basis  of  accounting,  and  our  results  arising 
with respect to that evaluation, is included in the key 
audit matters section of our report.
Based  on  the  work  we  have  performed,  we  have  not 
identified any material uncertainties relating to events 
or  conditions  that,  individually  or  collectively,  may 
cast  significant  doubt  on  the  group’s  and  the  parent 
company’s  ability  to  continue  as  a  going  concern  for 
a  period  of  at  least  twelve  months  from  when  the 
financial statements are authorised for issue.
In auditing the financial statements, we have concluded 
that  the  directors’  use  of  the  going  concern  basis 
of  accounting  in  the  preparation  of  the  financial 
statements is appropriate. 
The  responsibilities  of  the  directors  with  respect  to 
going concern are described in the ‘Responsibilities of 
directors  for  the  financial  statements’  section  of  this 
report.

O P I N I O N

Our opinion on the financial statements is unmodified
We have audited the financial statements of Instem plc 
(the ‘parent company’) and its subsidiaries (the ‘group’) 
for the year ended 31 December 2020 which comprise 
the  Consolidated  Statement  of  Comprehensive 
Income,  the  Consolidated  and  Company  Statements 
of Financial Position, the Consolidated and Company 
Statements  of  Cash  Flows,  the  Consolidated  and 
Company Statements of Changes in Equity, and notes 
to  the  financial  statements,  including  a  summary  of 
significant accounting policies. The financial reporting 
framework that has been applied in their preparation is 
applicable law and international accounting standards  
in conformity with the requirements of the Companies 
Act 2006, and as regards the parent company financial 
statements, as applied in accordance with the provisions 
of the Companies Act 2006.
In our opinion:
• 

in  accordance  with 

the financial statements give a true and fair view of 
the state of the group’s and of the parent company’s 
affairs as at 31 December 2020 and of the group’s 
profit for the year then ended;
the group financial statements have been properly 
prepared 
international 
accounting  standards  in  conformity  with  the 
requirements of the Companies Act 2006;
the parent company financial statements have been 
properly prepared in accordance with international 
accounting  standards  in  conformity  with  the 
requirements  of  the  Companies  Act  2006  and  as 
applied  in  accordance  with  the  provisions  of  the 
Companies Act 2006; and
the  financial  statements  have  been  prepared 
in  accordance  with  the  requirements  of  the 
Companies Act 2006.

• 

• 

• 

B A S I S   F O R   O P I N I O N

We  conducted  our  audit 
in  accordance  with 
International  Standards  on  Auditing  (UK)  (ISAs 
(UK))  and  applicable  law.  Our  responsibilities  under 
those standards are further described in the ‘Auditor’s 
responsibilities for the audit of the financial statements’ 
section  of  our  report.  We  are  independent  of  the 
group  and  the  parent  company  in  accordance  with 
the ethical requirements that are relevant to our audit 
of  the  financial  statements  in  the  UK,  including  the 

3 4

O V E R V I E W   O F   O U R   A U D I T   A P P R O A C H

Materiality

Overall materiality: 
Group: £282,000 (2019: £257,000), which represents 1% of the group’s revenue.
Parent company: £149,000 (2019: £133,000), which represents 0.3% of the parent 
company’s total assets.
Key audit matters were identified as; 
• 
Improper revenue recognition 
•  Carrying value of goodwill 
•  Going concern
Our auditor’s report for the year ended 31 December 2019 included one key audit 
matter that has not been reported as a key audit matter in our current year’s report. 
This relates to the carrying value of acquired intangibles, which was a key audit matter in the prior year specifically 
in relation to intangibles acquired on the acquisition of Leadscope Inc in that year.
We have performed the following audit work:
• 

an audit of the financial statements of the parent company and of the financial information of three of the 
components using component materiality (full scope audit); 
an audit of one or more account balances, classes of transactions or disclosures of the component (specified 
audit procedures) of nine further components to gain sufficient appropriate audit evidence at the group level; 
and

Key audit 
matters

Scoping

• 

• 

analytical procedures at group level for the remaining three components in the group during the year.

K E Y   A U D I T   M A T T E R S

Key audit matters are those matters that, in our professional judgement, 
were of most significance in our audit of the financial statements of the 
current period and include the most significant assessed risks of material 
misstatement (whether or not due to fraud) that we identified. These matters 
included those that had the greatest effect on the overall audit strategy; 
the allocation of resources in the audit; and directing the efforts of the 
engagement team. These matters were addressed in the context of our audit 
of the financial statements as a whole, and in forming our opinion thereon, 
and we do not provide a separate opinion on these matters. 

Description

Audit 
reponse

KAM

Disclosures Our results    

In the graph below, we have presented the key audit matters, significant risks and other risks relevant to the audit.

3 5

I N D E P E N D E N T   A U D I T O R ’ S   R E P O R T
T O   T H E   M E M B E R S   O F   I N S T E M   P L C   ( C O N T I N U E D )

K EY   AU D I T   M AT T E R   
–   G R OU P 

HOW   OU R   S C O P E   A D D R E S SE D   T H E 
M AT T E R   –   G R OU P

involved 

judgement 

is  management 

Improper recognition of revenue
We  identified  the  improper  recognition  of  revenue 
for  technology  enabled  outsourced  services  and 
professional  services  (service  revenue)  as  one  of  the 
most significant assessed risks of material misstatement 
due to fraud. 
There  is  a  risk  that  revenue  has  been  misstated 
through  improper  revenue  recognition  and  due  to 
the complexity of these revenue streams there is a risk 
that revenue recognition criteria is not being properly 
applied.
There 
in 
determining the amount of revenue that is accrued at 
year end for service revenue on open projects which are 
recognised  on  a  percentage  completion  basis  as  they 
are incomplete at the year end. We consider the risk to 
be heightened for service revenue and this has formed 
the  focus  of  our  work.  We  considered  this  risk  to  be 
specific to the accuracy and occurrence assertions.
We  further  consider  that  there  is  a  significant  risk 
present in relation to new contracts for service revenue 
entered  into  during  the  year  ended  31  December 
2020  (FY20),  specifically  with  regard  to  whether  the 
contract has been assessed and revenue is recognised 
appropriately  in  accordance  with  IFRS  15  ‘Revenue 
from Contracts with Customers’. 
Determining the amount of revenue to be recognised 
requires management to make significant judgements. 
These  judgements  include  determining  how  many 
performance obligations there are within each contract 
and  the  period  in  which  these  obligations  will  be 
fulfilled  and  recognised  as  revenue,  based  on  the 
group’s accounting policies.
This  is  considered  to  be  a  key  audit  matter  given  the 
importance of reported revenue to key stakeholders.

In  responding  to  the  key  audit  matter,  we  performed 
the following audit procedures:
•  Assessing the group’s revenue accounting policies 

• 

to check compliance with IFRS 15;
Identifying  and  assessing  new  key  contracts  for 
service  revenue  across  the  Group  and  considered 
and  challenged  whether  revenue  has  been 
recognised  correctly  in  accordance  with  IFRS  15 
by  considering  performance  obligations  under 
each  key  contract.  We  obtained  evidence  of 
achievement  of  those  obligations  by  the  Group, 
including assessment of management’s accounting 
papers where available. 

•  Challenging  a  number  of  significant  judgements 
made by management in respect of service revenue 
recognised  as  per  the  IFRS  15  accounting  policy, 
including the stated and implicit promises made to 
customers at the point of sale through an assessment 
of the contracts and of upgrades provided;

•  Testing  a  sample  of  service  revenue  contracts, 
focusing on contracts which remain open at the year 
end and are recognised on a percentage completion 
basis. We performed recalculations of the element 
of service revenue to be recognised as completed, 
agreeing to underlying signed statements of work, 
contracted  hourly  rates  and  timesheets,  and 
invoices to ensure the appropriateness of revenue 
recognition;

•  Recalculating  any  accrued  or  deferred  income 
balances  at  the  year-end  for  service  revenue 
contracts  selected  as  part  of  our  revenue  test  of 
detail procedures; and

•  Testing of cut off for service revenue by confirming 
the  appropriate  allocation  of  sales  to  the  correct 
perio

3 6

K EY   AU D I T   M AT T E R   
–   G R OU P 

HOW   OU R   S C O P E   A D D R E S SE D   T H E 
M AT T E R   –   G R OU P

Relevant disclosures in the Annual report and 
financial statements 2020 

impairment  analysis 

The Group’s accounting policy on revenue recognition 
is  shown  in  ‘Accounting  policies’  within  the  financial 
statements  on  pages  54  to  56;  and  related  disclosures 
are  included  in  Note  1  ‘Revenue  from  contracts  with 
customers’.
Carrying value of the group’s goodwill
We identified the carrying value of the group’s goodwill 
as one of the most significant assessed risks of material 
misstatement due to error.
Management’s  goodwill 
is 
completed  on  an  individual  cash  generating  unit 
(‘CGU’)  basis.  The  process  of  assessing  whether  an 
impairment  exists  under  International  Accounting 
Standard  (IAS)  36  ‘Impairment  of  Assets’  is  complex. 
Calculating the value in use, through forecasting cash 
flows  related  to  CGUs  and  the  determination  of  the 
appropriate  discount  rate  and  other  assumptions  to 
be applied is highly judgemental and as a result of the 
subjectivity of selecting the assumptions, can be subject 
to  management  bias.  The  selection  of  certain  inputs 
into the cash flow forecasts can significantly impact the 
results of the impairment assessment.
We  identified  significant  management  judgements  in 
the following areas:
•  The weighted average cost of capital (‘WACC’) for 
each CGU used to discount the cash flows within 
the group’s impairment assessment;

•  The  revenue  growth  rate  used  in  the  impairment 

forecasts; and

•  Allocation of revenue and costs across the group. 

Our results
Our  audit  testing  did  not  identify  any  material 
misstatements in relation to revenue recognition.

In  responding  to  the  key  audit  matter,  we  performed 
the following audit procedures: 
•  Evaluating  the  group’s  accounting  policies  to 
determine their compliance with the requirements 
of IAS 36; 

•  Testing the accuracy of management’s forecasting 
through a comparison of budget to actual data;
•  Challenging the appropriateness of management’s 
assumptions  and  sensitivities  relating  to  the  fair 
value  calculations  of  the  CGUs  and  estimated 
future  cash  flows,  including  the  growth  rate  and 
discount rate used to assess the level of headroom; 
•  Obtaining  and  assessing  management’s  allocation 
of revenue and costs to each CGU in the prepared 
forecasts  in  accordance  with  the  transfer  pricing 
policy;

•  Assessing  and  challenging  the  carrying  value  of 
goodwill in management’s impairment assessments. 
Our  challenge 
the  assumptions 
focused  on 
regarding  allocation  of  future  revenues  from  the 
underlying CGU relative to historic performance, 
including  whether  the  supporting  cash  flow 
forecasts  factor  in  COVID-19  considerations  and 
are in accordance with Board approved forecasts;
•  Performing  sensitivity  analysis  to  understand 
the  impact  of  any  reasonably  possible  changes  in 
assumptions, and evaluate the headroom available 
from different outcomes to assess whether goodwill 
could be impaired; and

•  Assessing  whether  the  group’s  disclosures  with 
respect  to  the  carrying  value  of  the  Group’s 
goodwill are adequate and the key assumptions are 
disclosed.

3 7

I N D E P E N D E N T   A U D I T O R ’ S   R E P O R T
T O   T H E   M E M B E R S   O F   I N S T E M   P L C   ( C O N T I N U E D )

K EY   AU D I T   M AT T E R   
–   G R OU P

HOW   OU R   S C O P E   A D D R E S SE D   T H E 
M AT T E R   –   G R OU P

Relevant disclosures in the Annual report and 
financial statements 2020
The  Group’s  accounting  policy  on  goodwill  is  shown 
in ‘Accounting Policies’ within the financial statements 
on  page  61  and  relevant  disclosures  in  respect  of  the 
carrying value of the group’s goodwill are presented in 
Note 11 ‘Intangible Assets’.

Our results 
Our  audit  testing  did  not  identify  any  material 
impairment  of  goodwill.  We  concluded  that  the 
assumptions used in management’s impairment model 
were  appropriate.  We  consider  the  disclosures  with 
respect to the carrying value of the group’s goodwill to 
be in accordance with IAS 36. 

Going concern
We  identified  to  going  concern  as  one  of  the  most 
significant assessed risks of material misstatement due 
to fraud and error as a result of the judgment required 
to  conclude  whether  there  is  a  material  uncertainty 
related to going concern.
As  stated  in  page  53,  Covid-19  is  one  of  the  most 
significant  economic  events  currently  faced  by  the 
UK and at date of this report its effects are subject to 
unprecedented  levels  of  uncertainty. This  event  could 
adversely impact the future trading performance of the 
group and parent company as such increases the extent 
judgement and estimation uncertainty associated with 
management’s  decision  to  adopt  the  going  concern 
basis of accounting in the preparation of the financial 
statements. 
In  undertaking  their  assessment  of  going  concern 
for  the  group,  the  Directors  considered  the  impact 
of    Covid-19  related  events  in  their  forecast  future 
performance of the Group and anticipated cash flows.

In  responding  to  the  key  audit  matter,  we  performed 
the following audit procedures: 
•  Obtaining  and  assessing  management’s  paper 
and  assessment  of  going  concern,  including  the 
forecasts covering the period to 31 December 2022 
and challenging the assumptions used in the cash 
flow forecasts, as approved by the Board;

•  Analysing  how  the  reasonableness  of  forecasts 
and  related  disclosures  may  be  impacted  by 
the  inherent  risk  associated  with  Covid-19  and 
how  this  may  affect  the  Group’s  and  the  parent 
company’s financial resources or ability to continue 
operations over the going concern period;

•  Obtaining  management’s 

extreme  downside 
scenario, which reflected management’s assessment 
of  uncertainties, 
and  which  management 
considered to be severe but plausible. We evaluated 
the  assumptions  regarding  the  revenue  and  costs 
during  the  forecast  period  and  the  proposed 
mitigating cost savings under this scenario;

•  Considering  whether  assumptions  are  consistent 
with  our  understanding  of  the  business  obtained 
during  the  course  of  the  audit,  the  impairment 
forecast  assumptions    and  the  changing  external 
circumstances  arising  from  the  government’s 
Covid-19 interventions;

•  Assessing the accuracy of management’s forecasting 
through a comparison of historical data to actual 
results  and  projections  for  following  periods  to 
post year end management accounts; 

•  Testing the adequacy of the supporting evidence for 
the cash flow forecast and  performing arithmetical 
checks on the forecast; and

•  Assessing the policies and disclosures in respect of 
going concern given in the financial statements for 
appropriateness. 

3 8

K EY   AU D I T   M AT T E R   
–   G R OU P 

HOW   OU R   S C O P E   A D D R E S SE D   T H E 
M AT T E R   –   G R OU P

Relevant disclosures in the Annual report and 
financial statements 2020 

The  Group’s  accounting  policy  on  going  concern  is 
shown  in  ‘Accounting  policies’  within  the  financial 
statements on page 52.

Our results
We have nothing to report in addition to that stated in 
the ‘Conclusions relating to going concern’ section of 
our report.

We did not identify any key audit matters relating to the audit of the financial statements of the parent company.

O U R   A P P L I C A T I O N   O F   M A T E R I A L I T Y

We apply the concept of materiality both in planning and performing the audit, and in evaluating the effect of identified 
misstatements on the audit and of uncorrected misstatements, if any, on the financial statements and in forming the 
opinion in the auditor’s report.

Materiality was determined as follows:

Materiality measure

Group

Parent company

Materiality for financial statements as a 
whole

We define materiality as the magnitude of misstatement in the financial statements that, 

individually or in the aggregate, could reasonably be expected to influence the economic decisions 

of the users of these financial statements. We use materiality in determining the nature, timing and 

extent of our audit work.

Materiality threshold

£282,000, which is 1% of the group’s revenue. 

Significant judgements made by auditor in 
determining the materiality

Revenue is considered to be the most appropriate 
benchmark for the group because it is a key 
performance indicator used by the Directors to 
report to investors on the financial performance 
of the Group.

Materiality for the current year is higher than 
the level that we determined for the year ended 
31 December 2019 to reflect the year-on-year 
revenue growth.

£149,000, which is 0.3% of the parent company’s 
total assets.

Total assets is considered to be the most 
appropriate benchmark for the parent company 
because the parent company’s principal activity is 
that of a holding company. 

Materiality for the current year is higher than the 
level that we determined for the year ended 31 
December 2019 to reflect the higher level of total 
assets in the parent company at the year end.

Performance materiality used to drive the 
extent of our testing

We set performance materiality at an amount less than materiality for the financial statements as a 

whole to reduce to an appropriately low level the probability that the aggregate of uncorrected and 

undetected misstatements exceeds materiality for the financial statements as a whole.

Performance materiality threshold

£197,400, which is 70% of financial statement 
materiality.

£104,300, which is 70% of financial statement 
materiality.

Significant judgements made by auditor in 

In determining performance materiality, we 

In determining performance materiality, we 

determining the performance materiality

made the following significant judgements:
consideration of control deficiencies 
• 
identified in prior years;

• 

• 

whether there were any significant 
adjustments made to the group’s financial 

statements in prior years; and 

assessment for any significant changes 
in business objectives and strategy of the 

group.

made the following significant judgements: 

• 

• 

• 

consideration of control deficiencies 
identified in prior years;

whether there were any significant 
adjustments made to the parent 

company’s financial statements in prior 

years; and 

assessment for any significant changes 
in business objectives and strategy of the 

parent company.

3 9

I N D E P E N D E N T   A U D I T O R ’ S   R E P O R T
T O   T H E   M E M B E R S   O F   I N S T E M   P L C   ( C O N T I N U E D )

O U R   A P P L I C A T I O N   O F   M A T E R I A L I T Y   ( C O N T I N U E D )

Materiality was determined as follows:

Materiality measure

Group

Parent company

Specific materiality

We determine specific materiality for one or more particular classes of transactions, account 

balances or disclosures for which misstatements of lesser amounts than materiality for the 

financial statements as a whole could reasonably be expected to influence the economic 

decisions of users taken on the basis of the financial statements.

Specific materiality 

We determined a lower level of specific 
materiality for related party transactions and 
directors’ remuneration.

We determined a lower level of specific 
materiality for related party transactions and 
directors’ remuneration.

Communication of misstatements to the audit 
committee

Threshold for communication

We determine a threshold for reporting unadjusted differences to the audit committee.

£14,100 and misstatements below that 
threshold that, in our view, warrant reporting 
on qualitative grounds.

£7,450 and misstatements below that threshold 
that, in our view, warrant reporting on 
qualitative grounds.

The graph below illustrates how performance materiality interacts with our overall materiality and the tolerance for 
potential uncorrected misstatements.

Overall materiality – Group

Overall materiality – Parent company

Revenues
£28.2m

PM
£197k, 70%

Total assets
£49.8m

PM
£104k, 70%

FSM
£282k, 1%

FSM
£149k, 0.3%

TFPUM  
£84.6k, 30%

TFPUM  
£44.7k, 30%

FSM: Financial statements materiality, PM: Performance materiality, TFPUM: Tolerance for potential uncorrected 
misstatements

4 0

A N   O V E R V I E W   O F   T H E   S C O P E 
O F   O U R   A U D I T

We  performed  a  risk-based  audit  that  requires  an 
understanding of the group and the parent company’s 
business, and in particular matters related to: 
Understanding the group, its components and their 
environments, including group-wide controls
•  The engagement team obtained an understanding 
of  the  group,  its  environment  and  risk  profile, 
including  group-wide  controls,  and  assessed  the 
risks  of  material  misstatement  at  the  group  level. 
We  considered    the  structure  of  the  group,  its 
processes and controls and the industries in which 
the components operate.

Identifying significant components and type of work 
to be performed on financial information of parent 
and other components
• 

In  order  to  address  the  risks  identified,  the 
engagement  team  performed  an  evaluation  of 
identified  components  to  assess  the  significant 
components  and  to  determine  the  planned  audit 
response  based  on  a  measure  of  materiality, 
calculated  by  considering 
the  component’s 
significance  as  a  percentage  of  the  group’s  total 
assets,  revenue  and  profit  before  taxation.  Of  the 
group’s  sixteen  components,  we  identified  four 
which,  in  our  view,  required  an  audit  of  their 
financial information (full scope audit), either due 
to their size or their risk characteristics. As a result 
of  this,  we  performed  an  audit  of  the  financial 
statements  of  the  parent  company  and  of  the 
financial  information  of  three  of  the  components 
using component materiality; 

•  We  identified  improper  recognition  of  revenue, 
the  carrying  value  of  the  group’s  goodwill  and 
going  concern  as  key  audit  matters  and  the  audit 
procedures  performed  in  respect  of  these  have 
been included in the key audit matters section of 
our report; 
•  We  performed 

audit  procedures 
specified 
over  certain  balances  and  transactions  of  nine 
components  to  give  appropriate  coverage  of 
balances.  Together,  the  components  subject  to 
full-scope  audits  and  specified  audit  procedures 
were  responsible  for  99%  of  the  group’s  revenue, 
86% of the group’s profit before tax, 98% of group’s 
EBITDA and 95% of the group’s total assets; and  
•  We  performed  analytical  procedures  at  group 
level  over  the  remaining  three  components. 
These  procedures,  together  with  the  additional 
procedures outlined above, performed at the group 
level gave us the audit evidence we needed for our 

opinion  on  the  group  financial  statements  as  a 
whole. All audit work has been undertaken by the 
group engagement team. 

Other information
The directors are responsible for the other information. 
The  other  information  comprises  the  information 
included in the annual report and financial statements, 
other  than  the  financial  statements  and  our  auditor’s 
report thereon. Our opinion on the financial statements 
does not cover the other information and, except to the 
extent otherwise explicitly stated in our report, we do 
not express any form of assurance conclusion thereon. 
In connection with our audit of the financial statements, 
our responsibility is to read the other information and, 
in doing so, consider whether the other information is 
materially  inconsistent  with  the  financial  statements 
or  our  knowledge  obtained  in  the  audit  or  otherwise 
appears  to  be  materially  misstated.  If  we  identify 
such  material  inconsistencies  or  apparent  material 
misstatements, we are required to determine whether 
there  is  a  material  misstatement  in  the  financial 
statements  or  a  material  misstatement  of  the  other 
information. If, based on the work we have performed, 
we  conclude  that  there  is  a  material  misstatement  of 
this other information, we are required to report that 
fact. 
We have nothing to report in this regard.

O U R   O P I N I O N   O N   O T H E R 
M A T T E R S   P R E S C R I B E D   B Y 
T H E   C O M P A N I E S   A C T   2 0 0 6   I S 
U N M O D I F I E D

In our opinion, based on the work undertaken in the 
course of the audit:
• 

the  information  given  in  the  strategic  report  and 
the directors’ report for the financial year for which 
the financial statements are prepared is consistent 
with the financial statements; and
the strategic report and the directors’ report have 
been prepared in accordance with applicable legal 
requirements.

• 

M A T T E R S   O N   W H I C H   W E   A R E 
R E Q U I R E D   T O   R E P O R T   U N D E R 
T H E   C O M P A N I E S   A C T   2 0 0 6

In the light of the knowledge and understanding of the 
group  and  the  parent  company  and  its  environment 
obtained  in  the  course  of  the  audit,  we  have  not 
identified  material  misstatements  in  the  strategic 
report or the directors’ report. 

4 1

I N D E P E N D E N T   A U D I T O R ’ S   R E P O R T
T O   T H E   M E M B E R S   O F   I N S T E M   P L C   ( C O N T I N U E D )

M A T T E R S   O N   W H I C H   W E   A R E 
R E Q U I R E D   T O   R E P O R T   B Y 
E X C E P T I O N

We have nothing to report in respect of the following 
matters in relation to which the Companies Act 2006 
requires us to report to you if, in our opinion:
• 

adequate  accounting  records  have  not  been  kept 
by the parent company, or returns adequate for our 
audit  have  not  been  received  from  branches  not 
visited by us; or
the  parent  company  financial  statements  are  not 
in  agreement  with  the  accounting  records  and 
returns; or
certain  disclosures  of  directors’  remuneration 
specified by law are not made; or

• 

• 

•  we  have  not  received  all  the  information  and 

explanations we require for our audit. 

R E S P O N S I B I L I T I E S   O F 
D I R E C T O R S   F O R   T H E 
F I N A N C I A L   S T A T E M E N T S

As explained more fully in the directors’ responsibilities 
statement,  the  directors  are  responsible  for  the 
preparation  of  the  financial  statements  and  for  being 
satisfied that they give a true and fair view, and for such 
internal control as the directors determine is necessary 
to  enable  the  preparation  of  financial  statements  that 
are  free  from  material  misstatement,  whether  due  to 
fraud or error.
In preparing the financial statements, the directors are 
responsible  for  assessing  the  group’s  and  the  parent 
company’s  ability  to  continue  as  a  going  concern, 
disclosing,  as  applicable,  matters  related  to  going 
concern and using the going concern basis of accounting 
unless the directors either intend to liquidate the group 
or the parent company or to cease operations, or have 
no realistic alternative but to do so.

A U D I T O R ’ S   R E S P O N S I B I L I T I E S 
F O R   T H E   A U D I T   O F   T H E 
F I N A N C I A L   S T A T E M E N T S

Our  objectives  are  to  obtain  reasonable  assurance 
about  whether  the  financial  statements  as  a  whole 
are  free  from  material  misstatement,  whether  due 
to  fraud  or  error,  and  to  issue  an  auditor’s  report 
that  includes  our  opinion.  Reasonable  assurance  is  a 
high level of assurance, but is not a guarantee that an 
audit  conducted  in  accordance  with  ISAs  (UK)  will 

4 2

always  detect  a  material  misstatement  when  it  exists. 
Misstatements  can  arise  from  fraud  or  error  and  are 
considered material if, individually or in the aggregate, 
they  could  reasonably  be  expected  to  influence  the 
economic decisions of users taken on the basis of these 
financial statements.
A  further  description  of  our  responsibilities  for  the 
audit  of  the  financial  statements  is  located  on  the 
Financial Reporting Council’s website at: www.frc.org.
uk/auditorsresponsibilities.  This  description  forms 
part of our auditor’s report.
Explanation  as  to  what  extent  the  audit  was 
irregularities, 
considered  capable  of  detecting 
including fraud
Irregularities,  including  fraud,  are  instances  of  non-
compliance  with  laws  and  regulations.  We  design 
procedures  in  line  with  our  responsibilities,  outlined 
above,  to  detect  material  misstatements  in  respect  of 
irregularities,  including  fraud.  Owing  to  the  inherent 
limitations  of  an  audit,  there  is  an  unavoidable  risk 
that material misstatements in the financial statements 
may not be detected, even though the audit is properly 
planned  and  performed  in  accordance  with  the  ISAs 
(UK). 
The  extent  to  which  our  procedures  are  capable  of 
detecting  irregularities,  including  fraud,  is  detailed 
below: 
•  We  obtained  an  understanding  of  the  legal  and 
regulatory  frameworks  applicable  to  the  parent 
company  and  the  group  and  the  industry  in 
which they operate. We determined that the most 
significant  laws  and  regulations  are:  international 
accounting  standards  in  conformity  with  the 
requirements of the Companies Act 2006, Quoted 
Companies Alliance (QCA) Corporate Governance 
Code and taxation laws; 

•  We obtained an understanding of how the parent 
company  and  the  group  are  complying  with 
those legal and regulatory frameworks by making 
inquiries  of  management,  those  responsible  for 
legal and compliance procedures and the company 
secretary. We corroborated our inquiries through 
our review of board minutes and papers provided 
to the Audit Committee; 

•  We  assessed  the  susceptibility  of  the  parent 
company’s  and  group’s  financial  statements  to 
material misstatement, including how fraud might 
occur.  Audit  procedures  performed  by  the  group 
engagement team included: 

company  and  the  company’s  members  as  a  body,  for 
our audit work, for this report, or for the opinions we 
have formed.

Michael Frankish
Senior Statutory Auditor
for and on behalf of Grant Thornton UK LLP
Statutory Auditor, Chartered Accountants
Manchester
10 April 2021

•  Assessing  the  design  and  implementation  of 
controls management has in place to prevent 
and detect fraud;

•  Obtaining  an  understanding  of  how  those 
charged  with  governance  considered  and 
addressed the potential for override of controls 
or  other  inappropriate  influence  over  the 
financial reporting process;

•  Challenging assumptions and judgments made 
by  management  in  its  significant  accounting 
estimates;
Identifying  and  testing  journal  entries,  in 
particular  any  journal  entries  posted  with 
unusual account combinations;

• 

•  Engaging  with  our  internal  tax  specialist  to 
address  the  risk  of  non-compliance  of  tax 
legislation;

•  Assessing  the  extent  of  compliance  with  the 
relevant  laws  and  regulations  as  part  of  our 
procedures on the related financial statement 
item; and 

•  Making  inquiries,  in  respect  of  fraud,  of 
those outside the finance team, including key 
management  and  the  project  management 
team.

•  The  assessment  of  the  appropriateness  of  the 
collective  competence  and  capabilities  of  the 
group  engagement  team  included  consideration 
of  the  group  engagement  team's  knowledge  of 
the  industry  in  which  the  client  operates,  and 
the  understanding  of,  and  practical  experience 
with,  audit  engagements  of  a  similar  nature  and 
complexity  through  appropriate  training  and 
participation; and

•  The  engagement  team’s  discussions  in  respect 
of  potential  non-compliance  with 
laws  and 
regulations  and  fraud  included  the  risk  of  fraud 
in  revenue  recognition.  We  identified  improper 
revenue recognition as a key audit matter. The key 
audit matters section of our audit report explains 
the  matter  in  more  detail  and  also  describes  the 
specific  procedures  we  performed  in  response  to 
the key audit matter. 

U S E   O F   O U R   R E P O R T

This report is made solely to the company’s members, 
as a body, in accordance with Chapter 3 of Part 16 of 
the  Companies  Act  2006.  Our  audit  work  has  been 
undertaken  so  that  we  might  state  to  the  company’s 
members  those  matters  we  are  required  to  state  to 
them in an auditor’s report and for no other purpose. 
To the fullest extent permitted by law, we do not accept 
or  assume  responsibility  to  anyone  other  than  the 

4 3

C O N S O L I D A T E D   S T A T E M E N T   O F   C O M P R E H E N S I V E   I N C O M E 

For the year ended 31 December 2020

Year ended
 31 December 
2020
£000

Year ended
 31 December 
2019
£000

 Note

REVENUE 

Employee benefits expense

Other expenses

EARNINGS BEFORE INTEREST, TAXATION, DEPRECIATION, AMORTISATION 
AND NON-RECURRING COSTS (ADJUSTED EBITDA)

Depreciation

Amortisation of intangibles arising on acquisition

Amortisation of internally generated intangibles

Amortisation of right of use assets

Impairment of goodwill and capitalised development

OPERATING PROFIT/(LOSS) BEFORE NON-RECURRING COSTS

OPERATING PROFIT/(LOSS) AFTER NON-RECURRING COSTS

Non-recurring costs

Finance income

Finance costs

1

2

2

13

11

11

8

11

2

3

4

5

PROFIT/(LOSS) BEFORE TAXATION

Taxation 

10

PROFIT/(LOSS) FOR THE YEAR

OTHER COMPREHENSIVE (EXPENSE)/INCOME

Items that will not be reclassified to profit and loss account:

Actuarial (loss)/gain on retirement benefit obligations

Deferred tax on actuarial gain/(loss)

Deferred tax on share options

Items that may be reclassified to profit and loss account:

Exchange differences on translating foreign operations

OTHER COMPREHENSIVE EXPENSE FOR THE YEAR

TOTAL COMPREHENSIVE INCOME/(EXPENSE) FOR THE YEAR

PROFIT/(LOSS) ATTRIBUTABLE TO OWNERS OF THE PARENT COMPANY

TOTAL COMPREHENSIVE INCOME/(EXPENSE) ATTRIBUTABLE TO OWNERS OF THE 
PARENT COMPANY

  The notes on pages 66 to 107 form part of these financial statements.

Earnings per share

Basic

Diluted

26

26

28,217

(16,508)

(5,790)

5,919

(138)

(664)

(736)

(572)

-

3,809

(606)

3,203

38

(692)

2,549

(275)

2,274

(2,537)

518

322

(1,697)

10

(1,687)

587

2,274

587

12.3

11.6

25,717

(13,609)

(7,244)

4,864

(155)

(523)

(755)

(607)

(3,175)

(351)

(302)

(653)

7

(255)

(901)

(22)

(923)

30

(6)

-

24

(208)

(184)

(1,107)

(923)

(1,107)

(5.7p)

(5.7p)

4 4

C O N S O L I D A T E D   S T A T E M E N T   O F   F I N A N C I A L   P O S I T I O N

At 31 December 2020

Company Registration No. 07148099

Note

£000

£000

£000

£000

2020

2019

ASSETS

NON-CURRENT ASSETS

Intangible assets

Property, plant and equipment

Right of use assets

Finance lease receivables

TOTAL NON-CURRENT ASSETS

CURRENT ASSETS

Inventories

Trade and other receivables

Finance lease receivables

Tax receivable

Cash and cash equivalents

TOTAL CURRENT ASSETS

TOTAL ASSETS

LIABILITIES

CURRENT LIABILITIES

Trade and other payables

Deferred income

Tax payable

Financial liabilities

Lease liabilities

Deferred tax liabilities

TOTAL CURRENT LIABILITIES

NON-CURRENT LIABILITIES

Financial liabilities

Retirement benefit obligations

Provision for liabilities 

Lease liabilities 

TOTAL NON-CURRENT LIABILITIES

TOTAL LIABILITIES

EQUITY 

Share capital

Share premium

Merger reserve

Share based payment reserve

Translation reserve

Retained earnings

11

13

8

8

14

15

8

21

16

17

18

21

19

8

22

19

23

24

8

25

27

27

27

27

27

18,023

238

1,742

128

50

6,093

41

724

26,724

2,958

9,878

-

268

608

90

1,131

3,868

250

1,476

2,048

28,172

2,432

930

92

(438)

18,108

237

2,165

175

20,131

20,685

33,632

53,763

13,802

6,725

20,527

36

6,921

39

1,158

5,957

2,662

8,942

404

301

565

506

559

1,804

250

2,004

1,662

13,135

2,432

654

82

(1,166)

14,111

34,796

13,380

4,617

17,997

TOTAL EQUITY ATTRIBUTABLE TO OWNERS OF THE PARENT

TOTAL EQUITY AND LIABILITIES 

33,236

53,763

16,799

34,796

The financial statements on pages 44 to 107 were approved by the board of directors and authorised for issue on 10 April 2021 
and are signed on its behalf by:

P J Reason 
Director  

N J Goldsmith
Director  

4 5

 
 
 
 
C O M P A N Y   S T A T E M E N T   O F   F I N A N C I A L   P O S I T I O N

At 31 December 2020

Company Registration No. 07148099

2020

2019

Note

£000

£000

£000

£000

ASSETS

NON-CURRENT ASSETS

Intangible assets

27

Investments

12

26,620

-

26,192

TOTAL NON-CURRENT ASSETS

26,647

26,192

CURRENT ASSETS

Trade and other receivables

Cash and cash equivalents

15

16

3,330

20,269

5,001

1,128

TOTAL CURRENT ASSETS

TOTAL ASSETS

LIABILITIES

CURRENT LIABILITIES

23,599

50,246

Trade and other payables

17

8,468

6,659

TOTAL CURRENT LIABILITIES

TOTAL LIABILITIES

EQUITY

Share capital

Share premium

Merger reserve

25

27

27

Share based payment reserve

2,048

28,172

14,066

929

Retained earnings

27

(3,437)

TOTAL EQUITY ATTRIBUTABLE TO OWNERS OF THE PARENT

TOTAL EQUITY AND LIABILITIES

8,468

8,468

41,778

50,246

1,662

13,135

14,066

654

(3,855)

6,129

32,321

6,659

6,659

25,662

32,321

As permitted by Section 408 of the Companies Act 2006, the Company has not presented its own statement of 
comprehensive income and related notes. The Company’s profit for the year was £266,000 (2019: £4,023,000).

The notes on pages 66 to 107 form part of these financial statements.

The financial statements on pages 44 to 107 were approved by the board of directors and authorised for issue 
on 10 April 2021 and are signed on its behalf by:

P J Reason 
Director 

N J Goldsmith
Director 

4 6

 
                                                                                                          
 
 
 
 
 
 
C O N S O L I D A T E D   S T A T E M E N T   O F   C A S H   F L O W S

For the year ended 31 December 2020

Note

£000

£000

£000

£000

2020

2019

CASH FLOWS FROM OPERATING ACTIVITIES

Profit/(loss) before taxation

Adjustments for:

Depreciation

Amortisation of intangibles 

Depreciation of right of use assets

Impairment of goodwill and capitalised development costs

Share based payment charge

Retirement benefit obligations

Finance income

Finance costs

Loss on disposal of fixed assets

13

11

8

11

2

23

4

5

CASH FLOWS FROM OPERATIONS BEFORE MOVEMENTS IN 

WORKING CAPITAL

Movements in working capital:

(Increase)/decrease in inventories

Decrease in trade and other receivables

Increase in trade, other payables and deferred income 

NET CASH GENERATED FROM OPERATIONS

Finance income

4

Finance costs

Income taxes

NET CASH GENERATED FROM OPERATING ACTIVITIES

CASH FLOWS FROM INVESTING ACTIVITIES

Capitalisation of development costs and software

Purchase of property, plant and equipment

Payment of deferred consideration

11

13

Purchase of subsidiary undertakings (net of cash acquired)

(1,272)

(141)

(277)

-

2,549

138

1,400

572

-

427

(512)

(38)

692

2

5,230

(14)

742

1,410

7,368

38

(648)

183

6,941

(1,344)

(91)

-

(1,268)

(901)

155

1,278

607

3,175

75

(475)

(7)

255

-

4,162

1

790

693

5,646

7

(255)

25

5,423

NET CASH USED IN INVESTING ACTIVITIES

(1,690)

(2,703)

CASH FLOWS FROM FINANCING ACTIVITIES

Proceeds from issue of share capital

Proceeds from government support loan

Lease interest payment

Repayment of lease liabilities 

8

Receipts from sublease of asset

Repayment of lease capital

15,423

810

-

(621)

40

(15)

648

-

(2)

(693)

7

(34)

NET CASH GENERATED FROM/(USED IN) FINANCING ACTIVITIES

NET INCREASE IN CASH AND CASH EQUIVALENTS 

Cash and cash equivalents at start of year

Effects of exchange rate changes on the balance of cash held in foreign 

currencies

CASH AND CASH EQUIVALENTS AT END OF YEAR

16

15,637

20,888

5,957

(121)

26,724

(74)

2,646

3,572

(261)

5,957

The notes on pages 66 to 107 form part of these financial statements.

4 7

C O M P A N Y   S T A T E M E N T   O F   C A S H   F L O W S

For the year ended 31 December 2020

Note

2020

2019

£000

£000

£000

£000

CASH FLOWS FROM OPERATING ACTIVITIES

Profit/(loss) before taxation

Adjustments for:

Amortisation of intangibles

Finance income

Finance cost

Impairment of investment

CASH FLOWS USED IN OPERATIONS BEFORE 
MOVEMENTS IN WORKING CAPITAL  

Movements in working capital:

Decrease/(increase)  in trade and other receivables

Increase in trade and other payables

NET CASH USED IN OPERATIONS

Finance income

Finance costs

NET CASH FROM/(USED IN) OPERATING 
ACTIVITIES

CASH FLOWS FROM INVESTING ACTIVITIES

Purchase of software intangible

(29)

NET CASH USED IN INVESTING ACTIVITIES

CASH FLOWS FROM FINANCING ACTIVITIES

Proceeds from issue of share capital

15,423

NET CASH GENERATED FROM FINANCING 
ACTIVITIES

NET INCREASE IN CASH AND CASH 
EQUIVALENTS  

Cash and cash equivalents at start of year

CASH AND CASH EQUIVALENTS AT END OF YEAR

16

The notes on pages 66 to 107 form part of these financial statements.

266

2

(57)

-

-

211

1,670

1,809

3,690

57

-

3,747

(29)

15,423

19,141

1,128

20,269

(4,023)

-

-

243

2,810

(970)

(1,014)

2,064

80

-

(243)

(163)

-

648

485

643

1,128

-

648

4 8

C O N S O L I D A T E D   S T A T E M E N T   O F   C H A N G E S   I N   E Q U I T Y

ATTRIBUTABLE TO OWNERS OF THE COMPANY

Share 
capital
£000

Share 
premium
£000

Merger
reserve
£000

Note

Shares 
based 
payment 
reserve
£000

Translation
reserve
£000

Retained 
earnings
£000

Total
 equity
£000

Balance at 31 December 2018 

1,592

12,535

1,598

1,010

Adjustment on initial application 
of IFRS 16

Adjusted balance as at 1 January 
2019

Loss for the year

Other comprehensive (expense)/
income for the year

Total comprehensive (expense)/
income

Shares issued

Share based payment

25

9

Reserve transfer on exercise of 
share options

-

-

-

-

1,592

12,535

1,598

1,010

-

-

-

70

-

-

-

-

-

-

-

-

600

834

-

-

-

-

-

-

-

-

75

(431)

Balance at 31 December 2019 

1,662

13,135

2,432

654

Profit for the year

Other comprehensive income/
(expense) for the year

Total comprehensive income

Shares issued

Share based payment

25

9

Reserve transfer on lapse of share 
options

Reserve transfer on exercise of 
share options

-

-

-

-

-

-

386

15,037

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

427

(65)

(86)

(630)

16,395

(68)

(68)

(698)

16,327

290

-

290

-

(923)

(923)

(184)

(208)

24

(208)

(899)

(1,107)

-

-

-

82

-

10

10

-

-

-

-

-

-

431

1,504

75

-

(1,166)

16,799

2,274

2,274

(1,697)

(1,687)

577

-

-

65

86

587

15,423

427

-

-

Balance as at 31 December 2020

2,048

28,172

2,432

930

92

(438)

33,236

The notes on pages 66 to 107 form part of these financial statements.

4 9

C O M P A N Y   S T A T E M E N T   O F   C H A N G E S   I N   E Q U I T Y

ATTRIBUTABLE TO OWNERS OF THE COMPANY

Share 
capital
£000

Share 
premium
£000

Merger
reserve
£000

Note

Share based 
payment 
reserve issued
£000

Balance as at 1 January 2019

1,592

12,535

13,232

1,010

Loss for the year

Shares issued

Share based payment

25

9

Reserve transfer on exercise of share 
options

-

70

-

-

-

600

-

-

-

834

-

-

Balance as at 31 December 2019

1,662

13,135

14,066

Profit for the year

Shares issued

Share based payment                                                           

25

9

Reserve transfer on lapse of share 
options

Reserve transfer on exercise of share 
options

-

386

-

-

-

-

15,037

-

-

-

-

-

-

-

-

Balance as at 31 December 2020

2,048

28,172

14,066

-

-

75

(431)

654

-

-

427

(66)

(86)

929

Retained 
earnings
£000

(263)

(4,023)

-

-

431

Total
 equity
£000

28,106

(4,023)

1,504

75

-

(3,855)

25,662

266

-

-

66

86

266

15,423

427

-

-

(3,437)

41,778

The notes on pages 66 to 107 form part of these financial statements.

5 0

 
A C C O U N T I N G   P O L I C I E S

G E N E R A L   I N F O R M A T I O N

A D O P T I O N   O F   I F R S

The principal activity and nature of operations of the 
Group  is  the  provision  of  world  class  IT  solutions  to 
the  life  sciences  market.  Instem’s  solutions  for  data 
collection,  management  and  analysis  are  used  by 
customers worldwide to meet the needs of life science 
and  healthcare  organisations  for  data-driven  decision 
making  leading  to  safer,  more  effective  products.  
Instem plc is a public limited company, listed on AIM, 
and  incorporated  in  England  and  Wales  under  the 
Companies  Act  2006  and  domiciled  in  England  and 
Wales.    The  registered  office  is  Diamond  Way,  Stone 
Business Park, Stone, Staffordshire, ST15 0SD.

S T A T E M E N T   O F   C O M P L I A N C E

The  financial  statements  of  the  Group  and  Company 
have  been  prepared  in  accordance  with  international 
accounting 
the 
requirements of the Companies Act 2006.

in  conformity  with 

standards 

The  Group  and  Company  financial  statements  have 
been  prepared  in  accordance  with  IFRS,  IAS  and 
International  Financial  Reporting 
Interpretations 
Committee (IFRICs) effective as at 31 December 2020. 
The Group and Company have chosen not to adopt any 
amendments or revised standards early.

I F R S s   A D O P T E D   I N   T H E   Y E A R

There  are  a  number  of  standards,  amendments  to 
standards, and interpretations which have been issued 
by the IASB which are all effective from 1 January 2020. 
The most significant of these are as follows:
• 

IAS  1  Presentation  of  Financial  Statements  and 
IAS 8 Accounting Policies, Changes in Accounting 
Estimates and Errors (Amendment – Definition of 
Material)
IFRS  3  Business  Combinations  (Amendment  – 
Definition of Business)

• 

•  Revised  Conceptual  Framework  for  Financial 

• 

Reporting
Interest Rate Benchmark Reform (Amendments to 
IFRS 9, IAS 39 and IFRS 7)

Those  standards,  amendments  to  standards,  and 
interpretations  have  been  adopted  and  did  not  have 
a  material  impact  on  the  accounting  policies  of  the 
Group.
The  practical  expedient  for  COVID-19  Rent  Related 
Concessions (Amendments to IFRS 16) have not been 
applied in the current reporting period. 

B A S I S   O F   P R E P A R A T I O N

The Group’s accounting reference date is 31 December.  
The  consolidated  financial  statements  have  been 
prepared on a going concern basis and prepared on the 
historical cost basis. Refer to the Going Concern note 
for further details. 
The Group has taken advantage of the audit exemption 
for nine of its subsidiaries, Instem Life Science Systems 
Limited (company number 04339129), Instem Scientific 
Solutions  Limited  (company  number  03598020), 
Instem  Clinical  Holdings  Limited  (company  number 
05840032), Instem Clinical Limited (company number 
06959053),  Instem  LSS  North  America  Limited 
(company  number  02126697),  Instem  LSS  Limited 
(company  number  03548215), 
Instem  Scientific 
Limited  (company  number  03861669),  Perceptive 
Instruments  Limited  (company  number  02498351), 
Samarind  Limited  (company  number  02105894),  by 
virtue of s479A of Companies Act 2006.  The Company 
has  provided  parent  guarantees  to  these  subsidiaries 
which  have  taken  advantage  of  the  exemption  from 
audit.
The  accounting  policies  set  out  below  have,  unless 
otherwise stated, been applied consistently to all years 
presented in these consolidated financial statements.

5 1

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

I F R S s   I S S U E D   B U T   N O T   Y E T 
E F F E C T I V E

There  are  a  number  of  standards,  amendments  to 
standards, and interpretations which have been issued 
by  the  IASB  that  are  effective  in  future  accounting 
periods that the Group has decided not to adopt early. 
The most significant of these is are as follows, which are 
all effective for the period beginning 1 January 2021: 
•  References to the Conceptual Framework
•  Proceeds  before  Intended  Use  (Amendments  to 

IAS 16)

•  Onerous Contracts – Cost of Fulfilling a Contract 

(Amendments to IAS 37)

•  Annual  Improvements  to  IFRS  Standards  2018-
2020 Cycle (Amendments to IFRS 1, IFRS 9, IFRS 
16, IAS 41)

•  Classification  of  Liabilities  as  Current  or  Non-

current (Amendments to IAS 1)

These  standards  are  not  expected  to  have  a  material 
impact on the entity in the current or future reporting 
periods and on foreseeable future transactions.

B A S I S   O F   C O N S O L I D A T I O N 

The consolidated financial statements incorporate those 
of the parent company, Instem plc, and its subsidiary 
undertakings  made  up  to  31  December  2020  and  31 
December 2019.
In preparing the consolidated financial statements, any 
intra-group  balances,  unrealised  gains  and  losses  or 
income and expenses arising from intra-group trading 
are  eliminated.  Where  accounting  policies  used  in 
individual financial statements of a subsidiary company 
differ  from  Group  policies,  adjustments  are  made  to 
bring these policies in line with Group policies.
Subsidiaries
Subsidiaries are entities in which the Group has rights to 
variable returns from its involvement with the investee 
and  has  the  ability  to  affect  those  returns  through  its 
power over the investee. Subsidiaries are consolidated 
from  the  date  on  which  control  is  transferred  to  the 
Group up until the date that control ceases.
All  subsidiary  companies  within  the  Group  have 
a  financial  year  end  date  of  31  December,  with  the 
exception  of  Instem  India  Pvt  Limited  which  has 
a  financial  year  end  date  of  31  March,  in  line  with 
Government of India regulations.

5 2

B U S I N E S S   C O M B I N A T I O N S

Acquisitions of businesses are accounted for using the 
acquisition method.  The consideration transferred in a 
business combination is measured at fair value, which 
is  calculated  as  the  sum  of  the  acquisition  date  fair 
values of the assets transferred by the Group, liabilities 
incurred  by  the  Group  to  the  former  owners  of  the 
acquiree and the equity interests issued by the Group 
in  exchange  for  control  of  the  acquiree.    Acquisition 
related costs are recognised in profit or loss as incurred.
At the acquisition date, the identifiable assets acquired 
and the liabilities assumed are recognised at their fair 
value,  except  that  deferred  tax  assets  or  liabilities  are 
recognised  and  measured  in  accordance  with  IAS  12 
‘Income taxes’.
Consideration  may  consist  of  deferred  consideration 
and contingent consideration. Deferred consideration 
is  not  based  on  any  performance  related  conditions 
and  is  payable  on  an  agreed  future  date.  Contingent 
consideration is based on certain performance related 
conditions  and  payable  on  an  agreed  future  date,  if 
those conditions are met. 
Deferred  consideration  and  contingent  consideration 
is  measured  at  their  acquisition-date  fair  value 
and  are  taken  into  account  in  the  determination  of 
goodwill.  Changes  in  the  fair  value  of  the  contingent 
consideration  that  qualify  as  measurement  period 
adjustments 
retrospectively,  with 
corresponding  adjustments  against  goodwill.    The 
subsequent  accounting  for  changes  in  the  fair  value 
of  the  contingent  consideration  that  do  not  qualify 
as measurement period adjustments depends on how 
the contingent consideration is classified.  Contingent 
consideration that is classified as an asset or a liability 
is  re-measured  at  subsequent  reporting  dates  with 
the  corresponding  gain  or  loss  being  recognised  in 
statement of comprehensive income. 

adjusted 

are 

G O I N G   C O N C E R N 

The financial position of the Group, its cash flows and 
liquidity position are set out in the primary statements 
within these financial statements.
Background 
The  Directors  have  adopted  the  going  concern  basis 
in  preparing  these  financial  statements  after  careful 
assessment of identified principal risks and the possible 
adverse impact on financial performance. The Directors 
have assessed the financial position and liquidity at the 

end of the reporting period and for the forecast period 
up to 31 December 2022, including sensitivity analysis. 
The going concern period covers the 12 months from 
the date of signing the financial statements. The process 
and key judgments in coming to this conclusion are set 
out below. 
The  Group’s  activities,  including  the  factors  likely 
to  affect  its  future  development,  performance  and 
position  are  set  out  in  the  Chairman’s  Statement  and 
Strategic report. The financial position of the Group, its 
cash  flows,  liquidity  position  and  borrowing  facilities 
are described in the Financial Review.
Current trading and liquidity
The  Group’s  trading  performance  for  the  year  ended 
31 December 2020 has been strong with Revenues of 
£28.2m and Adjusted EBITDA of £5.9m. Instem is fully 
operational, with all staff in all territories working from 
home in accordance with governmental guidelines, no 
staff  have  been  furloughed  and  there  is  no  intention 
of  curtailing  any  business  activities.  The  company 
has  continued  to  recruit  staff  across  its  geographic 
footprint. 
The  Group's  financing  arrangements  consist  of  a  net 
overdraft facility of £0.5m and a gross limit of £9.0m 
with NatWest Bank plc to support the Group's working 
capital needs.  As of 31 December 2020, the net facility 
was undrawn (2019: undrawn).  There are no material 
covenants associated with the facility. 
Following the announcement of the 2019 preliminary 
results Instem undertook an equity fund raise in July 
2020.  This  was  a  success  as  it  was  oversubscribed, 
raising gross funds of £15.75m, £15.0m net of expenses. 
A further six prestigious institutions were added to the 
list  of shareholders.  We spent £4.0m  initially  funding 
the  acquisition  of  The  Edge  on  1st  March  2021  and 
$13m  spent  on  the  initial  funding  of  the  d-wise 
acquisition on 1st April 2021. The group remains in a 
strong financial position as both of these acquisitions 
are expected to be accretive and cash generative.
During  2020,  the  Group  received  US  government 
support loan of $1.1m (£0.9m). The Group have applied 
for these sums to be forgiven and based on meeting all 
the  qualifying  criteria,  expect  to  receive  a  favourable 
outcome.
The  Group  acquired  the  earnings  enhancing,  cash 
generative  business  of  Leadscope  Inc.  in  November 
2019,  which  has  been  steadily  integrated  within  the 
Group  during  2020.  The  only  financial  obligation 
associated  with  this  acquisition  during  2021  is  a 
deferred  consideration  payment  of  $0.3m  due  in 
November 2021.

Other than the initial consideration paid for The Edge 
and  d-wise  there  are  no  further  financial  obligations 
payable  associated  with  the  acquisitions  until  2022, 
when  deferred  and  contingent  consideration  will  be 
due. 
Sensitivity Analysis
The  Company  has  considered  three  scenarios  which 
are also linked to the company’s risks when modelling 
the  forecast  results  and  cash  flow.  The  sensitivity 
assessment  includes  the  trading  performance  and 
cash flows of the Edge and d-wise from the date of the 
acquisitions.
(a) Base Case Scenario
The Group's detailed forecasts and projections, taking 
account  of  potential  risks  and  uncertainties  in  the 
business,  market  and  liquidity  through  sensitivity 
analysis, show that the Group has adequate resources to 
enable it to continue in operation through the forecast 
period  ending  31  December  2022  from  the  approval 
date  of  these  Consolidated  Financial  Statements. 
Accordingly,  the  Group  continues  to  adopt  the  going 
concern basis in preparing its Consolidated Financial 
Statements.
The uncertainty as to the future impact on the Group 
of the recent COVID-19 outbreak has been considered 
as part of the sensitivity analysis and as part of Group's 
adoption of the going concern basis. Thus far we have 
not observed any material impact on our overall existing 
business or in the level of new business opportunities 
that are being presented to us in the markets in which 
we operate. 
The  Group  has  a  significant  proportion  of  recurring 
revenue  (circa  60%  of  total)  from  annual  support  & 
maintenance and SaaS contracts from a well-established 
global customer base.  Revenue is supported by a largely 
fixed cost base comprising staff and offices. The Group 
had  net  current  assets  (excluding  deferred  income) 
of  £29.7m  as  of  31  December  2020  (2019:  £10.0m). 
The  deferred  income  recurs  each  year  on  renewal  of 
contracts and in general the Group has either received 
the related cash or has raised invoices for the services. 
The Group had positive cash reserves of £26.7m at 31 
December  2020,  in  addition  to  the  £0.5m  undrawn 
working  capital  facility,  although  £2.6m  of  the  cash 
was held in bank accounts in China, where it has been 
traditionally harder to repatriate funds quickly. There 
are however no long-term restrictions on the transfer 
of funds from the Group bank accounts in China and 
since the 2020 year end we have been able to repatriate 
£1.6m, significantly reducing our financial exposure to 
that territory.

5 3

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

(b) Sensitised Scenario
Further  stress  testing  has  been  carried  out  to  ensure 
that the Group has sufficient cash resources to continue 
its operations until at least 31 December 2022. In the 
downside  scenario  analysis  performed,  the  Board 
considered  the  potential  impact  of  the  COVID-19 
outbreak  on  the  Group's  results.  In  preparing  this 
analysis  the  following  key  risks  were 
included: 
COVID-19  causing  a  25%  loss  of  new  business  for 
the  next  twelve  months  and  the  risk  effect  of  foreign 
exchange  movements,  particularly  between 
the 
USD  and  GBP.  Despite  the  negative  impact  of  these 
sensitivities  the  model  demonstrated  that  the  Group 
remained  viable,  even  though  profitability  and  cash 
over the next twelve months was reduced. 
(c) Extreme downside Scenario
The Group then considered a more extreme situation 
where  the  impact  of  its  risks  would  be  more  severe 
such  as  a  significant  negative  impact  of  COVID-19 
continuing for an extended period of time into 2022, 
assuming there would be no new business at all. This 
sensitivity  exercise  resulted  in  the  Group  showing  an 
operating loss in each of the years ending 31 December 
2021  and  31  December  2022  and  exhausting  its  cash 
reserves from October 2021, having not drawn its bank 
facility. 
In a scenario where many of the identified risks occurred 
the Group would take remedial action to counter the 
dramatic  reduction  in  profit  and  cash  through  a  cost 
cutting  and  fund-raising  exercise  that  would  include 
staff  redundancies,  general  cost  control  measures, 
office space reduction and seeking alternative sources 
of funding.
These downside scenarios are considered unlikely. 
the  extreme  downside  scenario 
Even  applying 
sensitivity  analysis  throughout  the  forecast  period  to 
31 December 2022, by taking sufficient remedial action 
we expect the Group to remain a going concern.
Conclusion and Going Concern Statement
After considering the uncertainties described above, the 
directors have a reasonable expectation that the Group 
has  adequate  resources  to  continue  in  operational 
existence for the foreseeable future. For these reasons, 
they  continue  to  adopt  the  going  concern  basis  in 
preparing this annual report and accounts.

5 4

R E V E N U E   R E C O G N I T I O N

the 

services 

inception, 

technology 

transaction  price 

The  Group  generates  revenue  from  the  provision  of 
software licences, annual support, SaaS subscriptions, 
professional 
enabled 
and 
outsourced services. 
At  contract  inception,  an  assessment  is  completed  to 
identify the performance obligations in each contract.  
Performance obligations in a contract are either goods 
or services that are distinct or part of a series of goods 
or services that are substantially the same and have the 
same  pattern  of  transfer  to  the  customer.    Promises 
that are not distinct are combined with other promised 
goods or services in the contract, until a performance 
obligation is satisfied.  
At  contract 
is 
determined, being the amount that the Group expects 
to  receive  for  transferring  the  promised  goods  or 
services.  The  transaction  price  is  allocated  to  the 
performance  obligations  in  the  contract  based  on 
their  relative  standalone  selling  prices.  The  Group 
has  determined  that  the  contractually  stated  price 
represents  the  standalone  selling  price  for  each 
performance obligation.  
Revenue is recognised when a performance obligation 
has been satisfied by transferring the promised product 
or service to the customer. 
Software licences
Licence revenue comprises the sale of software licences 
across  the  Group  and  the  sale  of  compound  credits 
by  Leadscope.  The  revenue  from  software  licences 
is  recognised  when  the  customer  takes  possession  of 
the  software  which  is  usually  when  the  licence  key  is 
provided to the customer. This is because the software 
is  functional  at  the  time  the  licence  transfers  to  the 
customer and the Group is not required or expected to 
undertake activities that significantly affect the utility of 
the intellectual property by the customer. The revenue 
from  compound  credits  is  recognised  at  the  point  in 
time when the actual credits have been exercised, as the 
promises  in  these  contracts  are  a  single  performance 
obligation.
Annual support 
Customers  typically  enter  into  a  support  contract  for 
a period of twelve months. This contract provides the 
customer with access to technical support and software 
upgrades. The promises in these contracts are a single 
performance  obligation,  which  is  satisfied  over  time 
as the customer consumes the benefits of the service.  

Revenue in respect of the single performance obligation 
is recognised evenly over the contract term.
SaaS subscription and support
Customers  typically  enter  into  a  SaaS  contract  for  a 
period  of  twelve  months  and  pay  a  fixed  amount  in 
exchange for the usage of software on a hosted server 
over  a  specified  period  of  time  along  with  access  to 
maintenance  and  support.  Initial  SaaS  contracts  may 
also include some installation or customisation of the 
software  and  training  for  staff.  The  promises  in  this 
contract  are  considered  to  be  a  single  performance 
obligation  as  the  subscription  and  support  are 
highly  interdependent  on  one  another  given  that  the 
customers are required to take the full package of both 
the  software  and  support  services  i.e  Instem  would 
not  be  able  to  provide  the  support  services  without 
the provision of the software nor provide the software 
without the support services. 
The revenue is recognised over the period of the contract 
on a straight-line basis as the customer simultaneously 
receives and consumes the benefits of the software and 
services provided by the Group.
Subscription and support
into  by  our 
Subscription  contracts  are  entered 
Leadscope  business  and  the  associated  revenue  is 
classified as Subscription and support fees. Customers 
typically enter into a Subscription contract for a period 
of twelve months and pay a fixed amount in exchange 
for the usage of software on a hosted server, computer 
based version or customer server version (in customer 
premises)  over  a  specified  period  of  time  along  with 
access to maintenance and support.  Initial Subscription 
contracts may also include some installation services. 
The  promises  in  these  contracts  are  considered  to  be 
a  single  performance  obligation  as  the  subscription 
and support are highly interdependent on one another 
given  that  the  customers  are  required  to  take  the  full 
package  of  both  the  software  and  support  services 
i.e  Instem  would  not  be  able  to  provide  the  support 
services  without  the  provision  of  the  software  nor 
provide the software without the support services. 
The revenue is recognised over the period of the contract 
on a straight-line basis as the customer simultaneously 
receives and consumes the benefits of the software and 
services provided by the Group.
Professional services and technology enabled 
outsourced services
Customers  typically  enter  into  a  service  contract  to 
provide distinct service work based on clear statements 
of  work.  Service  work  includes,  but  is  not  limited  to, 
implementation  services,  training  and  outsourced 
services  work  relating  to  SEND  and  KnowledgeScan. 

The  promises  in  this  contract  are  considered  to  be  a 
single  performance  obligation  given  the  services  are 
interdependent  and  the  revenue  is  recognised  on  a 
percentage completion basis for fixed price contracts or 
as services are provided in respect of time and materials 
contracts. The Group has elected to take the practical 
expedient  to  apply  this  policy  to  its  portfolio  distinct 
service  contracts  given  the  similar  characteristics  in 
these types of contracts.
Bundled contracts
Software  licences,  professional  services  -  and  annual 
support are often bundled together in a contract.
Where the contract assessment identifies that the sale 
does not meet the criteria to be a distinct performance 
obligation,  due  to  a  lack  of  interdependence  between 
performance obligations, promises that are not distinct 
are combined with other promised goods or services in 
the contract, until a performance obligation is satisfied. 
Revenue  in  respect  of  this  bundled  performance 
obligation  is  recognised  over  the  period  of  the 
contracted obligation on a straight-line basis.
Amounts recoverable on contracts and deferred income
In most cases, customers are invoiced and payment is 
received in advance of revenue being recognised in the 
income  statement.  Amounts  recoverable  on  contracts 
and deferred income is the difference between amounts 
invoiced  to  customers  and  revenue  recognised  under 
the  policy  described  above.  If  the  amount  of  revenue 
recognised  exceeds  the  amounts  invoiced  the  excess 
amount  is  included  within  amounts  recoverable  on 
contracts.
Contract costs
The  incremental  costs  associated  with  obtaining  a 
contract are recognised as an asset if the Group expects 
to  recover  the  costs.    Costs  that  are  not  incremental 
to  a  contract  are  expensed  as  incurred.  Management 
determine  which  costs  are  incremental  and  meet  the 
criteria for capitalisation.  
Costs  to  fulfil  a  contract,  which  are  not  in  the  scope 
of  another  standard,  are  recognised  separately  as 
a  contract  fulfilment  asset  to  the  extent  that  they 
relate  directly  to  a  contract  which  can  be  specifically 
identified; the costs generate or enhance resources that 
will be used to satisfy the performance obligation and 
the  costs  are  expected  to  be  recovered.  Management 
judgement  to  determine  which  contract 
applies 
fulfilment  costs  meet  the  recognition  criteria,  and  in 
particular  if  the  costs  generate  or  enhance  resources 
used to satisfy the performance obligation. 
Costs to fulfil a contract which do not meet the criteria 
above are expensed as incurred.  

5 5

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

During  2020  the  business  implemented  a  process  to 
more  accurately  allocate  centrally  held  operational 
costs to the individual segments. However, it will take 
time  for  the  allocations  to  be  sufficiently  accurate 
for  the  Board  to  use  segmental  cost  information  for 
meaningful  decision  making.  Until  that  time,  cost 
allocations are not being provided to the Board as part 
of the monthly management information. 
The operations of the Group are managed centrally with 
group-wide  functions  including  sales  and  marketing, 
development, customer support, human resources and 
finance & administration.

F O R E I G N   C U R R E N C I E S 

  Monetary  assets  and 

Transactions  in  foreign  currencies  are  translated 
at  the  foreign  exchange  rate  ruling  at  the  date  of 
the  transaction. 
liabilities 
denominated  in  foreign  currencies  at  the  reporting 
date are translated at the foreign exchange rate ruling 
at  that  date.    Foreign  exchange  differences  arising 
on  translation  are  recognised  in  profit  or  loss.    Non-
monetary  assets  and  liabilities  that  are  measured 
in  terms  of  historical  cost  in  a  foreign  currency  are 
translated  using  the  exchange  rate  at  the  date  of  the 
transaction. 
  Non-monetary  assets  and  liabilities 
denominated  in  foreign  currencies  that  are  stated  at 
fair value are translated at foreign exchange rates ruling 
at the date the fair value was determined.  
The  assets  and 
liabilities  of  foreign  operations, 
including goodwill and fair value adjustments arising 
on  consolidation,  are  translated  at  foreign  exchange 
rates  ruling  at  the  reporting  date.    The  revenue  and 
expenses  of  foreign  operations  are  translated  at  an 
average rate for the year where this rate approximates 
to the foreign exchange rates ruling at the dates of the 
transactions, or otherwise at the exchange rate ruling at 
the date of each transaction.
Exchange  differences  arising  from  the  translation  of 
foreign operations are taken directly to the translation 
reserve.    They  are  released  into  profit  or  loss  upon 
disposal of the foreign operation.

Contract fulfilment asset
Contract  fulfilment  assets  are  amortised  over  the 
expected  contract  period  on  a  systematic  basis 
representing  the  pattern  in  which  control  of  the 
associated service is transferred to the customer.  
Practical exemptions
The  Group  has  taken  advantage  of  the  following 
practical exemptions:
•  not to account for significant financing components 
where  the  time  difference  between  receiving 
consideration and transferring control of goods (or 
services) to its customer is one year or less; 
expense  the  incremental  costs  of  obtaining  a 
contract when the amortisation period of the asset 
otherwise recognised would have been one year or 
less; and
to not disclose information relating to performance 
obligations  for  contracts  that  had  an  original 
expected  duration  of  one  year  or  less  or  where 
the  right  to  consideration  from  a  customer  is  an 
amount that corresponds directly with the value of 
the completed performance obligations.

• 

• 

A D J U S T E D   E A R N I N G S 
B E F O R E   I N T E R E S T , 
T A X A T I O N ,   D E P R E C I A T I O N , 
A M O R T I S A T I O N   A N D   N O N -
R E C U R R I N G   C O S T S   ( E B I T D A )

Adjusted  EBITDA  is  profit/(loss)  arising  from  the 
Group’s normal trading activities stated before interest, 
tax,  depreciation,  amortisation, 
impairment  of 
goodwill and capitalised development costs and non-
recurring items.
It is shown in this way to provide a clearer measure of 
underlying operating performance.

S E G M E N T A L   D I S C L O S U R E S

During  the  prior  year  the  business  was  divided  into 
three operating segments to better manage and report 
revenues;  Study  Management,  Regulatory  Solutions 
and In Silico Solutions (see note 1).
In  the  final  quarter  of  2019  the  board  decided  to 
allocate  certain  direct  costs  to  the  revenue  streams 
whilst  the  majority  of  costs  were  still  recorded  and 
reported centrally. The treatment in 2019 was based on 
information that was provided to the Instem Board, the 
Group’s Chief Operating Decision Maker, at the end of 
2019. 

5 6

The exchange rates used to translate the financial statements into Sterling (GBP) are as follows:

US Dollar 
(USD)

Hong Kong 
Dollar (HKD)

Chinese 
Renminbi
(RMB)

Indian Rupee
(INR)

Japanese
Yen (JPY)

Euro
(EUR)

Average rate for year ended 31 December 2019

1.2739

9.9825

8.7841

89.3413

138.8451

1.1389

Closing rate at 31 December 2019

1.3159

10.2457

9.1621

93.8148

142.9249

1.1735

Average rate for year ended 31 December 2020

1.2852

9.9893

8.8974

95.4317

137.1411

1.1283

Closing rate at 31 December 2020

1.3659

10.5882

8.9346

100.1070

140.7079

1.1124

N O N   R E C U R R I N G   I T E M S

Non  recurring  items  are  gains  or  losses  which  are 
infrequent or abnormal and are not part of the ongoing 
operations  of  the  business.  Non  recurring  items  may 
include restructuring costs, legal fees, M&A costs and 
other unusual gains or losses.

F I N A N C E   I N C O M E

Interest income is accrued on a time basis, by reference 
to the principal outstanding and at the effective interest 
rate applicable, which is the rate that exactly discounts 
estimated  future  cash  receipts  through  the  expected 
life  of  the  financial  asset  to  that  asset’s  net  carrying 
amount.    Finance  income  includes  exchange  gains 
(including exchange gains on the translation of intra-
group funding balances).

F I N A N C E   C O S T S

Net finance costs include interest payable, arrangement 
and service fees, exchange losses (including exchange 
losses  on  the  translation  of  inter-company  funding 
balances),  unwinding  discount  from  future  deferred 
consideration  payments,  finance  charges  on  leases 
and net interest on pension scheme liabilities.  Interest 
payable is recognised in the statement of comprehensive 
income as it accrues, using the effective interest method.

The consolidated financial statements are presented in 
Sterling (GBP), which is also the functional currency of 
the Parent Company. The functional currencies of each 
of the companies in the Group are as follows:

Instem plc

Sterling (GBP)

Instem Life Science Systems Limited 

Sterling (GBP)

Instem LSS Limited

Sterling (GBP)

Instem LSS (North America) Limited

US Dollars (USD)

Instem LSS Asia Limited

Hong Kong Dollars (HKD)

Instem Information Systems (Shanghai) 
Limited

Renminbi (RMB)

Instem Scientific Limited

Sterling (GBP)

Instem Scientific Solutions Limited

Sterling (GBP)

Instem Scientific Inc

US Dollars (USD)

Instem India Pvt Limited

Indian Rupees (INR)

Instem Clinical Holdings Limited

Sterling (GBP)

Instem Clinical Limited

Sterling (GBP)

Instem Clinical Inc

US Dollars (USD)

Perceptive Instruments Limited

Sterling (GBP)

Instem Japan K.K

Japanese Yen (JPY)

Samarind Limited

Sterling (GBP)

Notocord Systems S.A.

Euro (EUR)

Notocord Inc.

US Dollars (USD)

Leadscope Inc.

US Dollars (USD)

5 7

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

S H A R E - B A S E D   P A Y M E N T 
T R A N S A C T I O N S 

The Group issues equity-settled share-based payments 
to  certain  employees.  Equity-settled  share-based 
payments are measured at fair value at the date of grant 
by reference to the fair value of the equity instruments 
granted.    The  fair  value  determined  at  the  grant  date 
of equity-settled share-based payments is expensed on 
a straight-line basis over the vesting period, based on 
the Group’s estimate of the number of instruments that 
will eventually vest with a corresponding adjustment to 
equity.  Fair values are measured by use of the Binomial, 
Monte  Carlo  or  Black  Scholes  models.    The  expected 
life  used  in  the  model  has  been  adjusted,  based  on 
management’s  best  estimate,  for  the  effect  of  non-
transferability,  exercise  restrictions,  and  behavioural 
considerations.
Non-vesting  and  market  vesting  conditions  are  taken 
into  account  when  estimating  the  fair  value  of  the 
option  at  grant  date.  Service  and  non-market  vesting 
conditions  are  taken  into  account  by  adjusting  the 
number of options expected to vest at each reporting 
date.  Market  vesting  conditions  are  linked  to  the 
Group’s share price performance. - Non-market vesting 
conditions  are  linked  to  trading  performance  and 
service over defined time periods.
Cancelled  or  settled  options  are  accounted  for  as  an 
acceleration  of  vesting.    The  unrecognised  grant  date 
fair  value  is  recognised  in  profit  or  loss  in  the  year 
that  the  options  are  cancelled  or  settled.    Where  the 
terms of the options are modified and the modification 
increases the fair value or number of equity instruments 
granted,  measured  immediately  before  and  after  the 
modification, the incremental fair value is spread over 
the remaining vesting period.
Options  over  the  Company’s  shares  granted  to 
employees  of  subsidiaries  are  recognised  as  a  capital 
contribution in the subsidiaries and added to the cost 
of investment within Instem plc.

T A X A T I O N 

Taxation  expense  includes  the  amount  of  current 
income  tax  payable  and  the  charge  for  the  year  in 
respect of deferred taxation.
The income tax payable is based on an estimation of the 
amount due on the taxable profit for the year.  Taxable 
profit  is  different  from  profit  before  tax  as  reported 

in  the  statement  of  comprehensive  income  because  it 
excludes items of income or expenditure which are not 
taxable  or  deductible  in  the  year  as  a  result  of  either 
the  nature  of  the  item  or  the  fact  that  it  is  taxable  or 
deductible  in  another  year.    The  Group’s  liability  for 
current  tax  is  calculated  by  using  tax  rates  that  have 
been enacted or substantively enacted by the reporting 
date.
Income  tax  credits  for  research  and  development 
activities are recognised on a cash basis or when their 
receipt is reasonably certain.
Deferred tax is accounted for on the basis of temporary 
differences arising from the differences between the tax 
base and accounting base of assets and liabilities.
Deferred  tax  is  recognised  for  all  taxable  temporary 
differences, except to the extent where it arises from the 
initial recognition of an asset or liability in a transaction 
that is not a business combination.  Deferred tax assets 
are recognised only to the extent that it is probable that 
future  taxable  profits  will  be  available  against  which 
temporary differences can be utilised. Deferred tax is 
recognised  on  income  or  expenses  from  subsidiaries 
that will be assessed or allow for tax in future periods 
except where the Group is able to control the reversal of 
the timing difference and it is probable that the timing 
difference will not reverse in the foreseeable future.
Deferred tax is charged or credited to the statement of 
comprehensive income, except when it relates to items 
charged or credited directly to equity, in which case it is 
dealt with within equity.  It is calculated at the tax rates 
that are expected to apply to the period when the asset 
is realised or the liability is settled.

I N T A N G I B L E   A S S E T S

Intangible assets purchased separately from a business 
are capitalised at their cost. 
Intellectual Property, Customer Relationships, 
Brand Names and Patents
The  Group  makes  an  assessment  of  the  fair  value 
of  intangible  assets  arising  on  acquisitions.  These 
include Intellectual Property, Customer Relationships, 
Brand  Names  and  Patents.    An  intangible  asset  will 
be  recognised  as  long  as  the  asset  is  identifiable  and 
its fair value can be measured reliably.  An intangible 
asset is identifiable if it is separable or if it was obtained 
through  contractual  or  legal  rights.    Amortisation  is 
provided on the fair value of the asset and is calculated 

5 8

on a straight-line basis over its useful life.  The useful 
life  for  Intellectual  Property,  Customer  Relationships, 
Brand Names and Patents is between five and ten years.  
Amortisation  is  recognised  within  the  statement  of 
comprehensive  income.    All  intangible  assets  except 
Goodwill are amortised.
Goodwill
Goodwill on acquisitions, being the excess of the fair 
value of the cost of acquisition over the Group’s interest 
in the fair value of the identifiable assets and liabilities 
acquired,  is  capitalised  and  tested  for  impairment  on 
an annual basis.  
Any impairment is recognised immediately in profit or 
loss and is not subsequently reversed.  For the purpose 
of  impairment  testing  goodwill  is  allocated  to  cash 
generating  units  of  Instem  plc,  which  represent  the 
smallest identifiable group of assets that generates cash 
inflows that are largely independent of the cash inflows 
from other assets or groups of assets.
Computer Software
Computer software is carried at cost less accumulated 
amortisation  and  any  impairment  loss.    Externally 
acquired computer software and software licences are 
capitalised and amortised on a straight-line basis over 
their useful economic lives of three years.  Costs relating 
to development of computer software for internal use 
are  capitalised  once  the  recognition  criteria  of  IAS 
38 “Intangible Assets” are met.  When the software is 
available for its use, these costs are amortised over the 
estimated useful life of the software.
Internally generated intangible assets 
Expenditure on research activities is recognised in the 
statement of comprehensive income as incurred.
Expenditure arising from the Group’s development of 
software for sale to third parties is recognised only if all 
of the following conditions are met:
• 
• 

an asset is created that can be identified;
it  is  probable  that  the  asset  created  will  generate 
future economic benefits; 
the development cost of the asset can be measured 
reliably;
the Group has the intention to complete the asset 
and the ability and intention to use or sell it;
the  product  or  process 
commercially feasible; and 
sufficient  resources  are  available  to  complete  the 
development and to either sell or use the asset.
Capitalised  development  costs  are  those  which  are 
directly  attributable  to  the  development  activity  and 
include  employee  costs,  overheads  and  direct  third 
party costs.

technically  and 

is 

• 

• 

• 

• 

Where the criteria have not been achieved, development 
expenditure is recognised in profit or loss in the period 
in which it is incurred. 
Internally-generated  intangible  assets  are  amortised, 
once the product is available for use, on a straight-line 
basis  over  their  useful  lives  (five  to  eight  years).  Any 
capitalised internally developed software that is not yet 
complete is not amortised but is subject to impairment 
testing.
Gains  or  losses  arising  from  derecognition  of  an 
intangible asset are measured as the difference between 
the net disposal proceeds and the carrying amount of 
the asset and are recognised in profit or loss when the 
asset is derecognised.

P R O P E R T Y,  P L A N T  &  E Q U I P M E N T 

Property,  plant  and  equipment  are  stated  in  the 
statement of financial position at cost less accumulated 
depreciation and provision for impairments.
Depreciation is provided on all assets so as to write off 
the cost less estimated residual value on a straight-line 
basis as follows:
Short leasehold property - Over term of lease 
• 
• 
IT hardware and software - 25% - 33% per annum
The  expected  useful  lives  and  residual  values  of 
property,  plant  and  equipment  are  reviewed  on  an 
annual basis and, if necessary, changes in useful  lives 
are accounted for prospectively.  
The gain or loss arising on the disposal or retirement 
of an asset is determined as the difference between the 
sales  proceeds  and  the  carrying  amount  of  the  asset 
and  is  recognised  in  the  statement  of  comprehensive 
income.

L E A S I N G

The Group as a lessee
leasing  arrangements 
The  Group  makes  use  of 
principally for the provision of office space. The Group 
does  not  enter  into  sale  and  leaseback  arrangements. 
All the leases are negotiated on an individual basis and 
contain a wide variety of different terms and conditions 
such as purchase options and escalation clauses.
The  Group  assesses  whether  a  contract  is  a  lease 
or  contains  a  lease  at  inception  of  the  contract.  A 
lease  conveys  the  right  to  direct  the  use  and  obtain 
substantially all of the economic benefits of an identified 
asset for a period of time in exchange for consideration.

5 9

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

Some lease contracts contain both lease and non-lease 
components. These non-lease components are usually 
associated  with  facilities  management  services  at 
offices. The Group has elected to not separate its leases 
for  offices  into  lease  and  non-lease  components  and 
instead  accounts  for  these  contracts  as  a  single  lease 
component.
Measurement and recognition of leases as a lessee
All  leases  are  accounted  for  by  recognising  a  right  of 
use asset and a lease liability except for: 
•  Leases of low value assets; and 
•  Leases with a term of 12 months or less. 
Lease  liabilities  are  measured  at  the  present  value  of 
the  contractual  payments  due  to  the  lessor  over  the 
lease  term,  discounted  using  the  Group’s  incremental 
borrowing  rate  because  as  the  lease  contracts  are 
negotiated  with  third  parties  it  is  not  possible  to 
determine the interest rate that is implicit in the lease. 
The  incremental  borrowing  rate  is  the  estimated  rate 
that the Group could have to pay to borrow the same 
amount over a similar term and with similar security to 
obtain an asset of equivalent value. This rate is adjusted 
should the lessee entity have a different risk profile to 
that of the Group. 
Lease  payments  included  in  the  measurement  of  the 
lease liability are made up of fixed payments (including 
in substance fixed) and variable payments based on an 
index or rate.
In  such  cases,  the  initial  measurement  of  the  lease 
liability  assumes  the  variable  element  will  remain 
unchanged throughout the lease term. Other variable 
lease  payments  are  expensed  in  the  period  to  which 
they relate.
On initial recognition, the carrying value of the lease 
liability also includes: 
• 

amounts expected to be payable under any residual 
value guarantee; 
the exercise price of any purchase option granted 
in favour of the Group if it is reasonably certain to 
assess that option; 
any penalties payable for terminating the lease, if 
the  term  of  the  lease  has  been  estimated  on  the 
basis of termination option being exercised. 

• 

• 

Right of use assets are initially measured at the amount 
of  the  lease  liability,  reduced  for  any  lease  incentives 
received, and increased for: 
• 

lease payments made at or before commencement 
of the lease; 

6 0

• 
• 

initial direct costs incurred; and 
the  amount  of  any  provision  recognised  where 
the  Group  is  contractually  required  to  dismantle, 
remove  or  restore  the  leased  asset  (typically 
leasehold dilapidations).

Subsequent  to  initial  measurement  lease  liabilities 
increase as a result of interest charged at a constant rate 
on  the  balance  outstanding  and  are  reduced  for  lease 
payments made. Right of use assets are amortised on 
a  straight-line  basis  over  the  remaining  term  of  the 
lease or over the remaining economic life of the asset if, 
rarely, this is judged to be shorter than the lease term. 
When  the  Group  revises  its  estimate  of  the  term  of 
any  lease  (because,  for  example,  it  re-assesses  the 
probability of a lessee extension or termination option 
being  exercised),  it  adjusts  the  carrying  amount  of 
the lease liability to reflect the payments to make over 
the revised term, which are discounted at the revised 
discount  rate  at  the  date  of  re-assessment  or  effective 
date of a lease modification is used. The carrying value 
of lease liabilities is similarly revised when the variable 
element of future lease payments dependent on a rate 
or index is revised. The lease liability is remeasured only 
when the adjustment to lease payments takes effect and 
the  revised  contractual  payments  for  the  remainder 
of  the  lease  term  are  discounted  using  an  unchanged 
discount rate. In both cases an equivalent adjustment 
is made to the carrying value of the right of use asset, 
with the revised carrying amount being amortised over 
the remaining (revised) lease term. 
When the Group renegotiates the contractual terms of 
a lease with the lessor, the accounting depends on the 
nature of the modification: 
• 

if the renegotiation results in one or more additional 
assets  being  leased  for  an  amount  commensurate 
with the standalone price for the additional rights-
of-use obtained, the modification is accounted for 
as  a  separate  lease  in  accordance  with  the  above 
policy 
in all other cases where the renegotiated increases 
the scope of the lease (whether that is an extension 
to the lease term, or one or more additional assets 
being leased), the lease liability is remeasured using 
the  discount  rate  applicable  on  the  modification 
date, with the right of use asset being adjusted by 
the same amount 

• 

• 

if  the  renegotiation  results  in  a  decrease  in  the 
scope  of  the  lease,  both  the  carrying  amount  of 
the lease liability and right of use asset are reduced 
by  the  same  proportion  to  reflect  the  partial  of 
full  termination  of  the  lease  with  any  difference 
recognised  in  profit  or  loss.    The  lease  liability  is 
then further adjusted to ensure its carrying amount 
reflects  the  amount  of  the  renegotiated  payments 
over the renegotiated term, with the modified lease 
payments discounted at the rate applicable on the 
modification date. The right of use asset is adjusted 
by the same amount. 

In  determining  the  lease  term,  the  Group  assesses 
whether  it  is  reasonably  certain  to  exercise,  or  not 
to  exercise,  options  to  extend  or  terminate  a  lease. 
This  assessment  is  made  at  the  start  of  the  lease  and 
is  re-assessed  if  significant  events  or  changes  in 
circumstances occur that are within the lessee’s control.
The Group has elected to account for short-term leases 
assets using practical expedients. Instead of recognising 
a right-of-use asset and lease liability, the payments in 
relation to these are recognised as an expense in profit 
or loss on a straight-line basis over the lease term.
The Group applies judgement in determining whether 
individual  leases  can  be  accounted  for  as  a  portfolio. 
The judgements include an assessment of whether the 
leases  share  similar  characteristics  and  whether  the 
financial  statements  would  be  materially  different  if 
each lease was accounted for individually. The Group 
leases a number of properties in the jurisdictions from 
which it operates. In these jurisdictions the periodic rent 
is fixed over the lease term, with inflationary increases 
incorporated 
into  the  fixed  payments  stipulated 
in  the  lease  agreements.  Where  rental  agreements 
include  market  rate  escalations,  the  lease  liability  is 
re-measured when the change in cash payments takes 
affect. The Group also leases certain vehicles. Leases of 
vehicles  comprise  only  fixed  payments  over  the  lease 
terms.
The Group as a lessor
The Group acts as a lessor in relation to a sublease of 
part  of one  of  the  properties it leases. As  a  lessor the 
Group classifies its leases as either operating or finance 
leases. A lease is classified as a finance lease if it transfers 
substantially  all  the  risks  and  rewards  incidental  to 
ownership of the underlying asset and classified as an 
operating lease if it does not.
As the lease term is for the major part of the economic 
life  of  the  underlying  right  of  use  asset  this  has  been 
treated  as  a  finance  lease.  The  right  of  use  asset  has 
therefore  been  derecognised  and  a  net  investment 
in  the  lease  recognised  instead.  Interest  income  is 
recognised on the lease receivable. 

I M P A I R M E N T   O F   A S S E T S 
E X C L U D I N G   G O O D W I L L

The  carrying  value  of  property,  plant  and  equipment 
and intangible assets (excluding goodwill) is reviewed 
in 
impairment  whenever  events  or  changes 
for 
circumstances indicate the carrying value may not be 
recoverable.  
At each reporting date the Group reviews the carrying 
value of its property, plant and equipment and intangible 
assets to determine whether there is any indication that 
those assets have suffered an impairment loss.  If any 
such  indication  exists  the  recoverable  amount  of  the 
asset is estimated in order to determine the extent of 
the impairment loss.
Where the asset does not generate cash flows that are 
independent  from  other  assets  the  Group  estimates 
the  recoverable  amount  of  the  cash  generating  unit 
(‘CGU’)  to  which  the  asset  belongs.    A  CGU  is  the 
smallest identifiable group of assets that generates cash 
inflows that are largely independent of the cash inflows 
from other assets or groups of assets.
Recoverable  amount  is  the  higher  of  fair  value  less 
costs  to  sell  and  value  in  use.    In  assessing  value  in 
use, the estimated future cash flows are discounted to 
their  present  value  using  a  pre-tax  discount  rate  that 
reflects current market assessments of the time value of 
money and the risks specific to the asset, for which the 
estimates of future cash flows have not been adjusted.  
If  the  recoverable  amount  of  an  asset  is  estimated  to 
be less than its carrying amount, the carrying amount 
of  the  asset  is  reduced  to  its  recoverable  amount.  
An  impairment  loss  is  recognised  as  an  expense 
immediately.
Where  an  impairment  loss  subsequently  reverses, 
the  carrying  amount  of  the  assets  is  increased  to  the 
revised estimate of its recoverable amount, but so that 
the  increased  carrying  amount  does  not  exceed  the 
carrying  amount  that  would  have  been  determined 
had no impairment loss been recognised for the asset 
in  prior  years.    A  reversal  of  an  impairment  loss  is 
recognised in profit or loss immediately.

I M P A I R M E N T   T E S T I N G   O F 
G O O D W I L L

Cash-generating  units  to  which  goodwill  has  been 
allocated are tested for impairment at least annually.
An  impairment  loss  is  recognised  for  the  amount  by 
which CGU’s carrying amount exceeds its recoverable 
amount, which is the higher of fair value less costs of 
disposal and value-in-use. Both methods are applied to 
CGUs to determine the recoverable amount. 

6 1

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

To determine the value-in-use, management estimates 
expected future cash flows from each cash-generating 
unit and determines a suitable discount rate (WACC) 
in  order  to  calculate  the  present  value  of  those  cash 
flows.
The  data  used  for  impairment  testing  procedures 
are  directly  linked  to  the  Group’s  latest  approved 
budget, adjusted as necessary to exclude the effects of 
future  reorganisations  and  asset  enhancements.  The 
budgeted  unallocated  deparmental  costs  are  assigned 
to each CGU's using an approach agreed by the board. 
However, the board will not use this format to obtain a 
important business decisions. 
Impairment  losses  for  cash-generating  units  reduce 
first the carrying amount of any goodwill allocated to 
that cash-generating unit. Any remaining impairment 
loss is charged pro rata to the other assets in the cash-
generating unit.
To determine the fair value less cost to sell, management 
estimates the cash flows that will be received by selling 
the  CGU  at  the  end  of  the  reporting  period.  They 
then assess the characteristics of that particular CGU 
from the perspective of the market particpants at the 
measurement date. 
With  the  exception  of  goodwill,  all  assets  are 
subsequently  reassessed 
that  an 
impairment loss previously recognised may no longer 
exist.  An  impairment  loss  is  reversed  if  the  asset’s  or 
cash-generating unit’s recoverable amount exceeds its 
carrying amount.

indications 

for 

I N V E N T O R Y 

Inventory is stated at the lower of cost and net realisable 
value.   The  cost  of  work  in  progress  comprises  direct 
labour  and  other  direct  costs  and  includes  billable 
employee expenses.  
Provision  is  made  where  necessary  for  obsolete  and 
slow-moving inventory.

P R O V I S I O N   F O R   L I A B I L I T I E S

Provisions are recognised when there is a present legal 
or constructive obligation as a result of a past event, for 
which it is probable that an outflow of economic benefit 
will be required to settle the obligation and where the 
amount can be reliably estimated. 

6 2

F I N A N C I A L   I N S T R U M E N T S

Financial assets
The  Group  classifies  its  financial  assets  at  amortised 
cost.  The  classification  depends  on  the  purpose  for 
which the financial assets were acquired. Management 
determines  the  classification  of  its  financial  assets  at 
initial recognition.
Financial assets at amortised cost 
These  assets  arise  principally  from  the  provision  of 
goods and services to customers (eg trade receivables), 
but also incorporate other types of financial assets where 
the objective is to hold these assets in order to collect 
contractual cash flows and the contractual cash flows 
are solely payments of principal and interest.  They are 
initially recognised at fair value plus transaction costs 
that  are  directly  attributable  to  their  acquisition  or 
issue, and are subsequently carried at amortised cost, 
less provision for impairment.  
The  Group's  financial  assets  measured  at  amortised 
cost  comprise  trade  and  other  receivables  and  cash 
and cash equivalents in the consolidated statement of 
financial position.  
Trade receivables
Trade  and  other  receivables  are  amounts  due  from 
customers  for  services  performed  in  the  ordinary 
course  of  business.  If  collection  is  expected  in  one 
year  or  less  (or  in  the  normal  operating  cycle  of  the 
business, if longer) they are classified as current assets, 
if not, they are presented as non-current assets. 
Trade  and  other  receivables  are  measured  at  the 
transaction price in accordance with IFRS 15.
The  Group  applies  the  IFRS  9  simplified  approach  to 
measuring expected credit losses which uses a lifetime 
expected  loss  allowance  for  all  trade  receivables  and 
contract assets. To measure the expected credit losses, 
trade receivables and contract assets have been grouped 
based  on  shared  credit  risk  characteristics  and  the 
days past due. The expected loss rates are based on the 
payment profiles of sales over a period of 5 years before 
31  December  2020  (2019:  31  December  2019)  and 
the corresponding historical credit losses experienced 
within this period. The historical loss rates are adjusted 
to  reflect  current  and  forward-looking  information 
on  macroeconomic  factors  affecting  the  ability  of  the 
customers to settle the receivables.  The contract assets 
relate  to  unbilled  revenue,  which  have  performance 
obligations  to  be  completed. The  contract  assets  have 

substantially the same risk characteristics as the trade 
receivables for the same types of contracts. The Group 
has therefore concluded that the expected loss rates for 
trade receivables are a reasonable approximation of the 
loss rates for the contract assets.
At each reporting date management assesses whether 
any events have occurred which have had a detrimental 
effect  on  the  estimated  future  cash  flows  of  the  asset 
causing a financial asset to become credit-impaired. If 
the credit risk is significant a provision is posted based 
on  the  recoverable  amount  the  Group  is  expected 
to  receive  per  management’s  assessment.    Specific 
provisions  of  this  nature  are  excluded  from  the 
simplified  credit  loss  calculation  using  the  provision 
matrix.
Cash and cash equivalents
Cash and cash equivalents comprise cash in hand and 
cash deposits which are readily convertible to a known 
amount  of  cash.    Cash  and  cash  equivalents  in  the 
statement of financial position include bank overdrafts. 
An offset position is reported as the Group has a legal 
right to set off and any settlement would be on a net 
basis. For the purposes of the cash flow statement, cash 
and cash equivalents include bank overdrafts which are 
repayable on demand and are an integral part of Group 
cash management.  
Investments
Investments  in  subsidiaries  are  recorded  at  cost  in 
the  statement  of  financial  position.    They  are  tested 
for  impairment  when  there  is  objective  evidence  of 
impairment.  Any impairment losses are recognised in 
the statement of comprehensive income in the period 
they occur.
Intercompany receivables
Impairment  provisions  for  receivables  from  related 
parties  and  loans  to  related  parties  are  recognised 
based  on  a  forward  looking  expected  credit  loss 
model.    The  methodology  used  to  determine  the 
amount of the provision is based on whether there has 
been  a  significant  increase  in  credit  risk  since  initial 
recognition  of  the  financial  asset.    For  those  where 
the  credit  risk  has  not  increased  significantly  since 
initial recognition of the financial asset, twelve month 
expected credit losses along with gross interest income 
are  recognised.    For  those  for  which  credit  risk  has 
increased  significantly,  lifetime  expected  credit  losses 
along  with  the  gross  interest  income  are  recognised.  
For  those  that  are  determined  to  be  credit  impaired, 
lifetime  expected  credit  losses  along  with  interest 
income on a net basis are recognised. The amount of 
any  provision  is  recognised  in  the  income  statement 
within other operating costs.

liabilities  and  equity 

Financial liabilities and equity
instruments  are 
Financial 
classified according to the substance of the contractual 
arrangements entered into.  
Interest-bearing  government 
loans  are  recorded 
initially  at  their  fair  value,  net  of  direct  transaction 
costs.  Such  loans  are  subsequently  carried  at  their 
amortised  cost  and  finance  charges  are  recognised  in 
the statement of comprehensive income over the term 
of the instrument using an effective rate of interest.
An  equity  instrument  is  any  contract  that  evidences 
a  residual  interest  in  the  assets  of  the  Group  after 
deducting all of its liabilities.
Bank borrowings and loan notes
Interest-bearing 
loan  notes  and  bank  overdrafts 
are  recorded  initially  at  their  fair  value,  net  of  direct 
transaction  costs.  Such  instruments  are  subsequently 
carried at their amortised cost and finance charges are 
recognised in the statement of comprehensive income 
over the term of the instrument using an effective rate 
of interest.  
Finance charges are accounted for on an accruals basis 
to the statement of comprehensive income.  Overdrafts 
are offset against cash and cash equivalents when the 
Group has a legal right of off-set.
Trade and other payables
Trade and other payables are not interest bearing and 
are initially recognised at fair value and subsequently 
at amortised cost.
Ordinary share capital
For ordinary share capital, the par value is recognised 
in share capital and the premium in the share premium 
reserve.

R E T I R E M E N T   B E N E F I T S 

Defined contribution schemes
A  defined  contribution  scheme  is  a  pension  plan 
under  which  the  Group  pays  a  fixed  contribution 
to  a  scheme  with  an  external  provider.    The  amount 
charged  to  the  statement  of  comprehensive  income 
in respect of pension costs and other post-retirement 
benefits is the total of contributions payable in the year.  
Differences between contributions payable in the year 
and  contributions  actually  paid  are  shown  as  either 
other payables or other receivables in the statement of 
financial position.  The Group has no further payment 
obligations once the contributions have been paid.

6 3

A C C O U N T I N G   P O L I C I E S   ( C O N T I N U E D )

Defined benefit scheme
A  defined  benefit  scheme  is  a  pension  plan  under 
which the Group pays contributions in order to fund 
a  defined  amount  of  pension  that  the  employees 
under  the  scheme  will  receive  on  retirement.    The 
cost of providing the benefits is determined using the 
projected unit credit method with actuarial valuations 
being carried out regularly. 
An asset or liability is recognised equal to the present 
value  of  the  defined  benefit  obligation,  adjusted  for 
unrecognised past service costs and reduced by the fair 
value of plan assets.
Actuarial  gains  and  losses  are  recognised  in  the 
statement  of  other  comprehensive  income  in  the 
year  in  which  they  occur,  whilst  expected  returns  on 
plan  assets,  servicing  costs  and  financing  costs  are 
recognised in the statement of comprehensive income.
The  rate  used  to  discount  the  benefit  obligations  is 
based  on  market  yields  for  high  quality  corporate 
bonds with terms and currencies consistent with those 
of the benefit obligations.

S I G N I F I C A N T   J U D G E M E N T S 
A N D   E S T I M A T E S 

In  the  process  of  applying  the  Group’s  accounting 
policies, which are described above, management have 
made  judgements  and  estimations  about  the  future 
that  have  the  most  significant  effect  on  the  amounts 
recognised  in  the  financial  statements.  The  estimates 
and  underlying  assumptions  are  reviewed  on  an  on-
going  basis.  Revisions  to  accounting  estimates  are 
recognised  in  the  period  in  which  the  estimate  is 
revised if the revision affects only that period or in the 
period  of  revision  and  future  periods  if  the  revision 
affects both current and future periods.
Significant judgements
The  following  judgments  have  the  most  significant 
effect on the financial statements.
Revenue Recognition
The  Group  generates  revenue  from  the  provision  of 
software licences, annual support, SaaS subscriptions, 
subscription  and  support,  professional  services  and 
technology  enabled  outsourced  services.  Software 
licences, professional services and annual support are 
often bundled together in a contract which do not meet 
the criteria to be distinct performance obligation, due 
to  a  lack  of  interdependence  between  performance 
obligations. Promises that are not distinct are combined 

with other promised goods or services in the contract, 
until a performance obligation is satisfied. 
Judgement  is  applied  in  determining  how  many 
performance obligations there are within each contract 
and  the  period  in  which  these  obligations  will  be 
fulfilled  and  recognised  as  revenue,  based  on  the 
Group’s  accounting  policies.  For  SaaS  subscription 
and support, the Group determines for each contract 
whether  the  promise  is  considered  to  be  a  single 
performance obligation as the subscription and support 
are  highly  interdependent  on  one  another  given  that 
the customers are required to take the full package of 
both the software and support services i.e Instem would 
not  be  able  to  provide  the  support  services  without 
the provision of the software nor provide the software 
without the support services. 
Impairment of goodwill
CGUs are identified by the fact they are separate legal 
entities and so have their own intangible and tangible 
assets, other current assets and generate cash from their 
products  and  services  that  are  separately  identifiable 
from  one  another.  The  judgements  were  made  in 
respect of the WACC, the revenue growth rate applied 
and the allocation of costs across the CGUs. 
The  carrying  value  of  goodwill  must  be  assessed  for 
impairment  annually.  This  requires  a  value  in  use 
estimate  which  is  dependent  on  estimation  of  future 
cashflows and the use of an appropriate discount rate 
to discount those cash flows to their present value. The 
carrying value of goodwill as at 31 December 2020 was 
£10.2m  (2019:  £10.2m).  Refer  to  note  11  for  further 
detail.
Management approved to use the same pre-tax WACC 
across  all  CGUs,    as  it  was  determined  based  on  the 
Groups risks and there were no specific risks related to 
each CGU or CGU’s jurisdiction.
The  revenue  growth  rates  and  margins  are  based 
on  current  Board-approved  budgets  and  forecasts 
covering a period of five years. Management estimates 
are  considering  business  growth  rates,  payroll  and 
other  cost  base  increases  further  details  are  provided 
in note 11.
The  data  used  for  impairment  testing  procedures  are 
directly  linked  to  the  Group’s  latest  approved  budget, 
adjusted  as  necessary  to  exclude  the  effects  of  future 
reorganisations and asset enhancements. The budgeted 
unallocated  departmental  costs  are  assigned  to  each 
CGU  applying  a  standard  methodology  approved  by 
the Board.

6 4

and the use of an appropriate discount rate to discount 
those  cash  flows  to  their  present  value.  The  carrying 
amounts  of  acquired  intangibles  and  software  at  the 
reporting date was £3.6m and £4.3m respectively (2019: 
£4.2m and £3.7m). There was an impairment charge of 
£0.7m on the year ended 31 December 2019. Refer to 
note 11 for further detail.
Pension scheme
As  stated  above  the  Group  operates  a  defined  benefit 
pension  scheme.  At  the  end  of  each  six  monthly 
reporting  period  the  Group  seeks  external  expert 
actuarial  advice  on  the  assumptions  to  apply  to  the 
calculation  of  the  scheme’s  liabilities.  The  Group 
then engages a separate, independent firm of pension 
advisors to calculate the scheme surplus or deficit at the 
reporting  date  for  accounting  purposes.  The  scheme 
deficit at 31 December 2020 is £3.9m (2019: £1.8m).
Revenue Recognition
For  Professional  services  and  technology  enabled 
outsourced  services  revenue  recognition  there  is  a 
significant  estimation  of  the  planned  project  hours, 
which  determines  the  percentage  of  completion  of 
service revenue contracts. Before the project is started, 
the  project  manager  estimates  the  budgeted  hours 
needed for the agreed services. If the project is expected 
to  overrun  then  the  project  manager  will  amend  the 
expected budgeted hours in accordance with the new 
available information which also mitigates the risk of 
early revenue recognition. 

Development Costs
The  Group  invests  on  a  continual  basis  in  the 
development  of  software  for  sale  to  third  parties.  
There  is  a  continual  process  of  enhancements  to  and 
expansion  of  the  software  with  judgement  required 
in  assessing  whether  the  development  costs  meet 
the  criteria  for  capitalisation.  These  judgements  have 
been applied consistently year on year. In making this 
judgement, the Group evaluates, amongst other factors, 
whether there are future economic benefits beyond the 
current period, the stage at which technical feasibility 
has been achieved, management’s intention to complete 
and use or sell the product, the likelihood of success, 
availability  of  technical  and  financial  resources  to 
complete  the  development  phase  and  management’s 
ability to measure reliably the expenditure attributable 
to  the  project.  Judgement  is  therefore  required  in 
determining the practice for capitalising development 
costs.
Estimation uncertainty
Information  about  estimations  and  assumptions  that 
may have the most significant affect on recognition and 
measurement of assets, liabilities, income and expenses 
is provided below. Actual results may be substantially 
different.
Provision for liabilities
Provisions are recognised when the Group has a present 
obligation  (legal  or  constructive)  as  a  result  of  a  past 
event, it is probable that the Group will be required to 
settle the probable outflow of resources, and a reliable 
estimate can be made of the amount of the obligation.  
As at 31 December 2020, the Group has a provision of 
£0.25m (2019: £0.25m) in respect of historical contract 
disputes as the directors have considered that the above 
provision  conditions  have  been  met.  The  provision 
represents the best estimate of the risks and considers 
all information and legal input received by the Group. 
Contingent consideration
Where acquisition consideration includes consideration 
contingent  on  performance  outcomes  being  met,  the 
consideration  is  valued  at  the  acquisition  date  based 
on performance forecasts available at the time. Those 
forecasts  are  reviewed  at  the  reporting  date  and  the 
consideration revised where materially different.
Impairment of other intangible assets
Other  intangibles  assets  consist  of  assets  acquired 
(customer  relationships,  intellectual  property  and 
brand  names)  as  part  of  the  net  assets  of  certain 
subsidiaries  and  software,  being  mainly  capitalised 
development  costs.  Impairment  testing  requires  if 
there  is  an  indication  that  the  other  intangible  asset 
is  impaired  and  the    value  in  use  method  would  be 
estimated  based  on  an  estimation  of  future  cashflows 

6 5

N O T E S   T O   T H E   F I N A N C I A L   S T A T E M E N T S

1.  R E V E N U E   F R O M   C O N T R A C T S   W I T H   C U S T O M E R S

a.  Segmental Reporting

The Group has disaggregated revenue into various categories in the following tables which are intended to depict how 
the nature, amount, timing and uncertainty of revenue and cash flows are affected by economic factors.

Prior to 2019, the Group reported its business as one operating segment; Global Life Sciences. The Board managed 
the Group by monitoring its revenue streams and considered the cost base as a whole. Historically the Group’s finance 
systems  have  recorded  costs  centrally  and  have  managed  costs  in  this  way.  Without  systems  capable  of  allocating 
costs accurately, the Board concluded that there was only one operating segment in which revenues and costs were 
reported. Over recent years the Group has expanded both organically and through acquisition, increasing the number 
of products and services. During 2019 the business was divided into three operating segments to better manage and 
report revenues; Study Management, Regulatory Solutions and In Silico Solutions. 

There  has  been  an  ongoing  project  to  enhance  the  quality  of  management  information  (MI)  following  the 
implementation of a new finance system. During the final quarter of 2019 certain direct costs were allocated to the 
revenue streams whilst the majority of costs were still recorded and reported centrally. The treatment in 2019 was 
based on information that was provided to the Instem Board, the Group’s Chief Operating Decision Maker, at the end 
of 2019.

During 2020 the business implemented a process to more accurately allocate centrally held operational costs to the 
individual  segments.  However,  it  will  take  time  for  the  allocations  to  be  sufficiently  accurate  for  the  Board  to  use 
segmental cost information for meaningful decision making. 

The  operations  of  the  Group  are  managed  centrally  with  group-wide  functions  including  sales  and  marketing, 
development, customer support, human resources and finance & administration.

The analysis provided below reflects costs directly attributable to the respective segments in 2020 and 2019, which 
are primarily third party costs of sale and costs of allocated employees. The remaining indirect operational costs are 
accounted for centrally and are not allocated to specific segments.

6 6

1.  R E V E N U E   F R O M   C O N T R A C T S   W I T H   C U S T O M E R S   ( C O N T I N U E D )

SEGMENTAL REPORTING
2020

Study 
Management
£000

Regulatory 
Solutions
£000

Total revenue

15,054

Direct attributable costs

(3,516)

Contribution to indirect overheads

11,538

Central unallocated indirect costs

9,839

(2,046)

7,793

In Silico 
Solutions
£000

3,324

(1,630)

1,694

Adjusted EBITDA

Depreciation

Amortisation of intangibles arising on acquisition

Amortisation of internally generated intangibles

Depreciation of right of use assets

Impairment of goodwill and capitalised development costs

OPERATING PROFIT  BEFORE NON-RECURRING COSTS

OPERATING PROFIT AFTER NON-RECURRING COSTS

Non-recurring costs

Finance income

Finance costs

PROFIT BEFORE TAXATION

SEGMENTAL REPORTING
2019

Study 
Management
£000

Regulatory 
Solutions
£000

In Silico 
Solutions
£000

15,188

(4,370)

10,818

9,037

(2,111)

6,926

1,492

(660)

832

Total revenue

Direct attributable costs

Contribution to indirect overheads

Central unallocated indirect costs

Adjusted EBITDA

Depreciation

Amortisation of intangibles arising on acquisition

Amortisation of internally generated intangibles

Depreciation of right of use assets

Impairment of goodwill and capitalised development costs

OPERATING LOSS BEFORE NON-RECURRING COSTS

OPERATING LOSS AFTER NON-RECURRING COSTS

Non-recurring costs

Finance income

Finance costs

LOSS BEFORE TAXATION

Total
£000

28,217

(7,192)

21,025

(15,106)

5,919

(138)

(664)

(736)

(572)

-

3,809

(606)

3,203

38

(692)

2,549

Total
£000

25,717

(7,141)

18,576

(13,712)

4,864

(155)

(523)

(755)

(607)

(3,175)

(351)

(302)

(653)

7

(255)

(901)

6 7

1.  R E V E N U E   F R O M   C O N T R A C T S   W I T H   C U S T O M E R S   ( C O N T I N U E D )

REVENUE BY PRODUCT TYPE

Licence fees

Annual support fees

SaaS subscription and support fees

Professional services

Technology enabled outsourced services

REVENUE BY GEOGRAPHICAL LOCATION

UK

Rest of Europe

North America

Rest of World

NON-CURRENT ASSETS EXCLUDING DEFERRED TAXATION BY 
GEOGRAPHICAL LOCATION

UK

Rest of Europe

North America

Rest of World

2020
£000

3,477

8,917

8,024

1,603

6,196

28,217

2020
£000

2,740

5,656

14,586

5,235

28,217

2020
£000

17,549

1,436

524

622

20,131

2019
£000

3,501

8,418

6,444

1,773

5,581

25,717

2019
£000

3,414

5,051

12,701

4,551

25,717

2019
£000

17,779

1,107

432

881

20,199

There were no customers which represented more than 10% of the Group’s revenue in 2020 (2019: none).

6 8

1.  R E V E N U E   F R O M   C O N T R A C T S   W I T H   C U S T O M E R S   ( C O N T I N U E D )

b.  Contract Balances

Amounts 
recoverable on 
contracts

£000

At 1 January

1,395

Transfer in the period from amounts recoverable on 
contracts to trade receivables

(1,395)

Amounts included in deferred income that was 
recognised as revenue during the period

Deferred income on acquisition of Leadscope Inc.

Cash received in advance of performance and not 
recognised as revenue during the period

Excess of revenue recognised over cash being 
recognised during the period

At 31 December

-

-

-

1,826

1,826

2020

2019

Deferred 
income

(8,942)

-

8,942

-

(9,878)

-

(9,878)

Amounts 
recoverable on 
contracts

2,807

(2,807)

-

-

1,365

1,365

Deferred 
income

(8,625)

-

8,625

(818)

(8,124)

-

(8,942)

Amounts recoverable on contracts and deferred income are included within “trade and other receivables” and 
“deferred income” respectively on the face of the statement of financial position.

Amounts recoverable on contracts predominately relate to fulfilled obligations on service contracts where billing is 
in arrears. At the point where completed work is invoiced, the contract asset is derecognised and a corresponding 
receivable recognised.

Deferred income relates to consideration received from customers in advance of work being completed plus 
maintenance and support which is invoiced in advance.

c.  Remaining performance obligations

The vast majority of the Group’s contracts are for the delivery of software and services within the next 12 months for 
which the practical expedient in paragraph 121(a) of IFRS 15 applies. However, certain bundled contracts have been 
entered into for which both the original contract was greater than 12 months and the Group’s right to consideration 
does not correspond directly with the performance.

The amount of revenue that will be recognised in future periods on these contracts is as follows:

2021
£000

50

Revenue

2022
£000

9

2023
£000

-

d.  Contract Costs

It is expected that commissions paid are recoverable. These have therefore been capitalised as an asset and are 
amortised over the term of the contract. 

As of 31 December 2020, the carrying value of costs to obtain contracts which have been capitalised is the amount of 
£nil (2019: £nil). Amortisation of £nil (2019: £0.1m) was recognised during the year. 

The entity has applied the practical expedient available in paragraph 94 of IFRS 15 to recognise the incremental 
costs of obtaining a contract as an expense when incurred where the amortisation period of the asset that the entity 
otherwise would have recognised is one year or less.

6 9

2.  O P E R A T I N G   P R O F I T   B E F O R E   N O N - R E C U R R I N G   C O S T S

Profit from operations includes the following significant items:

Depreciation and amounts written off property, plant and equipment - owned assets

Amortisation of intangible assets

Depreciation of right to use assets

2020
£000

138

736

572

Research and development costs

2,177

Impairment of goodwill

Impairment of capitalised development

Short life lease expenses

Amounts payable to Grant Thornton UK LLP and their associates in
respect of both audit and non-audit services:

Fees payable to the Group’s auditors:

for the audit of the Parent Company and consolidated financial statements

for the audit of the Company’s subsidiaries

Non-audit services:

Taxation services - Compliance

Taxation services - Advisory

Corporate finance services

-

-

95

177

-

21

53

-

251

The following tables analyse employee benefits operating expense and other expenses:

2020
£000

2019
£000

155

1,278

607

1,711

2,482

693

21

93

15

27

69

30

234

2019
£000

Employee benefits expense

Staff costs (see note 6)

15,447

13,534

Share based payments

Health and life insurance

Other benefits

427

630

4

75

-

-

16,508

13,609

Other expenses

Operating lease rentals

Software maintenance charges

Licence costs 

Third party costs 

Other expenses

-

918

1,543

1,567

1,762

5,790

28

731

1,457

2,812

2,216

7,244

7 0

3 .   N O N - R E C U R R I N G   C O S T S

Guaranteed Minimum Pension (GMP) equalisation provision

Legal costs relating to historical contract disputes 

Acquisition costs

4 .   F I N A N C E   I N C O M E

5 .   F I N A N C E   C O S T S

Right of use asset interest income

Other interest

Loans and overdrafts

Unwinding discount on deferred consideration

Net interest charge on pension scheme

Lease interest cost

Right of use asset interest cost

Foreign exchange losses

2020
£000

5

149

452

606

2020
£000

7

31

38

2020
£000

38

70

34

-

96

454

692

2019
£000

-

106

196

302

2019
£000

-

7

7

2019
£000

34

-

60

2

118

41

255

7 1

6 .   E M P L O Y E E S

Group

2020
Number

2019
Number

Average monthly number (including non-executive directors)

By role:

Directors, administration and supervision

Software design, sales and customer service

Employment costs:

Wages and salaries

Social security costs

Other pension costs

39

265

304

13,109

1,334

1,004

15,447

Average monthly number (including non-executive directors)

Company

2020
Number

By role:

Non-executive directors

Employment costs:

Wages and salaries

Social security costs

3

138

15

153

39

229

268

11,444

1,148

942

13,534

2019
Number

3

120

13

133

7 2

7 .   D I R E C T O R S '   E M O L U M E N T S

Amounts payable by Instem plc:

Emoluments

Amounts payable by subsidiary companies:

Emoluments

Defined contribution pension contributions

Total emoluments

2020
£000

138

385

44

567

2019
£000

120

359

43

522

Number of directors to whom retirement benefits are accruing under:

Defined contribution schemes         

2

2

2020
Number

2019
Number

The remuneration of the highest paid director during the year ended 31 December 2020 was 276,000 (2019: 
£261,000). Directors’ remuneration analysed by director is shown on page 29.

8 .   L E A S E S

Lease liabilities are presented in the statement of financial position as follows:

 Current

 Non current

2020
£000

488

1,596

2,084

2019
£000

565

2,004

2,569

Nature of leasing activities in the capacity of lessee
The Group leases a number of offices in the jurisdictions from which it operates. In these jurisdictions the periodic 
rent is fixed over the lease term, with inflationary increases incorporated into the fixed payments stipulated in the 
lease agreements. Where rental agreements include market rate escalations, the lease liability is re-measured when 
the change in cash payments takes effect. The Group also leases certain vehicles.  Leases of vehicles comprise only 
fixed payments over the lease terms. With the exception of short term leases, leases of low value underlying assets 
and a lease held for a telephone system, with less than twelve months remaining on the lease as at 31 December 
2020, each lease is reflected on the balance sheet as a right of use asset and a lease liability.

Each lease generally imposes a restriction that, unless there is a contractual right for the Group to sublet the asset 
to another party, the right of use asset can only be used by the Group. Leases are either non cancellable or may only 
be cancelled by incurring a termination fee. Some leases contain an option to extend the lease for a further term. 
For office leases the Group must keep those properties in a good state of repair and return the properties in their 
original condition at the end of the lease.

7 3

8 .   L E A S E S   ( C O N T I N U E D )

The table below describes the nature of the Groups leasing activities by type of right of use asset recognised on the 
balance sheet:

Right of use assets

No of right 
of use assets 
leased

Range of 
remaining 
term

No of leases 
with extension 
options

No of leases 
with options 
to purchase

No of leases 
with payments 
linked to an 
index

No of leases
 with 
termination 
options

Office buildings

Vehicles

10

3

2.7 years

2.9 years

10

0

0

0

1

0

0

0

Right of use assets

As at 1 January 2019

Derecognition of sublease 

Amortisation

Exchange adjustment

As at 31 December 2019

Additions

Lease modification and remeasurement

Amortisation

Exchange adjustment

As at 31 December 2020

Land & buildings
£000

Motor vehicles
£000

2,978

(249)

(590)

19

2,158

123

32

(564)

(38)

1,711

24

-

(17)

-

7

31

-

(8)

-

30

Lease liabilities

Land & buildings
£000

Motor vehicles
£000

As at 1 January 2019

Interest expense 

Lease payments 

Exchange adjustment

As at 31 December 2019

Additions

Lease modification and remeasurement

Interest expense

Lease payments

Exchange adjustment

As at 31 December 2020

3,020

117

(676)

102

2,563

123

32

95

(710)

(50)

2,053

22

1

(17)

-

6

31

-

-

(6)

-

31

Total
£000

3,002

(249)

(607)

19

2,165

154

32

(572)

(38)

1,741

Total
£000

3,042

118

(693)

102

2,569

154

32

95

(716)

(50)

2,084

7 4

8 .   L E A S E S   ( C O N T I N U E D )

Reconciliation of movements of liabilities to cash flows arising from financing activities

Changes from financing cash flows

Land & buildings
£000

Motor vehicles
£000

At 31 December 2019 

Interest expenses 

Payment of lease liabilities

As at 31 December 2020

676

95

615

710

17

0

6

6

Lease liability maturity analysis:

As at 31 December 2019

1 year or less
£000

2 to 5 years
£000

After five years
£000

Lease liabilities

565

1,950

54

As at 31 December 2020

1 year or less
£000

2 to 5 years
£000

After five years
£000

Lease liabilities

488

1,538

58

Total
£000

693

95

621

716

Total
£000

2,569

Total
£000

2,084

The following amounts in respect of leases, where the company is a lessee, have been recognised in consolidated 
statement of comprehensive income:

Expenses relating to short-term leases 

Low value lease expense

Interest expense

Amortisation of right of use assets

2020
£000

45

95

95

572

2019
£000

21

7

118

607

 The total cash outflow for leases in 2020 was £0.7m (2019: £0.7m).

7 5

8 .   L E A S E S   ( C O N T I N U E D )

Finance lease receivable

Nature of leasing activities in the capacity of lessor
The Group also acts as a lessor in relation to a sublease of part of one of the properties rented. As the lease term is 
for the major part of the economic life of the underlying right of use asset this has been treated as a finance lease. 
The right of use asset has therefore been derecognised and a net investment in the lease recognised instead. Interest 
income is recognised on the lease receivable. 

Movement in net investment in leases in relation to sub leases during the year ended 31 December 2020 and 31 
December 2019 are as follows:

As at 1 January 2019

Addition

Interest earned

Less: Rental income received

At 31 December 2019

Addition

Interest earned

Less: Rental income received

Exchange adjustment

At 31 December 2020

Minimum undiscounted lease payments receivable are as follows:

Within 1 year

Between 1 and 2 years

Between 2 and 3 years

Between 3 and 4 years

Later than 5 years

2020
£000

47

48

50

33

-

178

Reconciliation of minimum undiscounted lease payments to net investment in the lease:

Total minimum undiscounted lease payments receivable 

Unearned finance income

Net investment in the lease

2020
£000

178

(9)

169

7 6

£000

-

221

1

(8)

214

-

8

(48)

(5)

169

2019
£000

47

48

50

51

40

236

2020
£000

236

(22)

214

8 .   L E A S E S   ( C O N T I N U E D )

Finance lease receivable maturity analysis:

As at 31 December 2019

1 year or less
£000

2 to 5 years
£000

After five years
£000

Finance lease receivable

39

175

-

As at 31 December 2020

1 year or less
£000

2 to 5 years
£000

After five years
£000

Finance lease receivable

41

128

-

Total
£000

214

Total
£000

169

9 .   S H A R E   B A S E D   P A Y M E N T

Equity-Settled Share Option Plan

The Remuneration Committee can grant options to employees of the Group. Options are granted with a fixed exercise 
price at the date of grant and the contractual life is generally ten years from the grant date. Options generally vest 
and become exercisable after three years where certain performance criteria have been met. Share options issued to 
directors and senior employees generally carry profitability (EBITDA) or market-based performance conditions. The 
Group awarded share options to all employees during 2020 which are only subject to continued employment and have 
no other performance conditions.

Outstanding at the beginning of the year

Granted

Number

983,303

535,728

Lapsed

(21,788)

Exercised 

(238,141)

Outstanding at end of the year 

1,259,102

Exercisable at end of year

525,518

2020

2019

Weighted average 
exercise price (£)

0.60

0.00

0.09

1.75

0.11

0.25

Number

1,465,548

7,740

(16,804)

(473,181)

983,303

678,659

Weighted average 
exercise price (£)

0.85

0.10

0.10

1.37

0.60

0.83

The options outstanding at 31 December 2020 had exercise prices of £nil, £0.10, £0.90, £1.76 and £2.22 (2019: £nil, 
£0.10, £0.90, £1.75, £1.76 and £2.22) and a weighted average remaining contractual life of 7 years 3 months (2019: 5 
years 3 months).

A charge of £0.427m (2019: £0.075m) arose in respect of share based payments.

The fair value of options granted in the year was £1.9m (2019: £0.02m).

During the year, the average share price in respect of share options exercised was £1.75 (2019: £3.17)

7 7

9 .   S H A R E   B A S E D   P A Y M E N T   ( C O N T I N U E D )

New  options  for  535,728  shares  were  granted  in  the  year  which  are  valued  using  the  Monte-Carlo  option-pricing 
model. The fair market value has been estimated using the following key assumptions:

Grant date

27 April & 26 June

Expected life (years)

Share price at grant date

Exercise price

Dividend yield

Risk free rate 

Volatility

Fair value of options (average)

3

£4.45

Nil

0.00%

N/A

N/A

£4.45

6 May

3

£4.50

Nil

0.00%

N/A

N/A

£4.50

19 May

26 June

3

£4.50

Nil

0.00%

0.02%

38.6%

£3.34

3

£4.45

Nil

0.00%

0.02%

38.6%

£3.31

The share options awarded in the year comprised of LTIP awards with performance targets, Bonus nil cost options with 
no performance targets and conditional awards with no performance targets. The LTIP awards vest when certain share 
price conditions are met. The other options are only subject to continued employment and have no other performance 
targets. 

The  fair  value  calculation  includes  an  assumption  regarding  share  price  volatility  of  38.6%  for  LTIP  awards  only. 
The  historical  volatility  of  the  Group’s  share  price  was  calculated  using  daily  data  over  a  3  year  period,  which  is 
commensurate with the remaining performance period.

7 8

1 0 .   T A X A T I O N

Income taxes recognised in profit or loss:

Current tax:

UK corporation tax in respect of previous years 

Adjustments in respect of R&D tax credit

Foreign tax

Foreign tax in respect of previous years

Total current tax credit

Deferred tax:

Current year charge

Adjustment in respect of previous years

Retirement benefit obligation

Impact of rate change

Total deferred tax charge

Total income tax charge recognised in the current year

2020
£000

(4)

250

(146)

39

139

(165)

(57)

(90)

(102)

(414)

(275)

2019
£000

28

464

(404)

67

155

(96)

(11)

(70)

-

(177)

(22)

The UK cororation tax is calculated at the prevailing rate of 19%. Foreign tax liabilities are calculated at the 
prevailing tax rates applying in the overseas tax jurisdictions.

In the Spring Budget 2021, the Government announced that from 1 April 2023 the corporation tax rate will increase 
to 25%. Since the proposal to increase the rate to 25% had not been substantively enacted at the balance sheet date, 
its effects are not included in these financial statements. However, it is likely that the overall effect of the change, had 
it been substantively enacted by the balance sheet date, would not have a material impact.

7 9

1 0 .   T A X A T I O N   ( C O N T I N U E D )

The income tax (expense)/credit can be reconciled to the accounting profit as follows:

Profit/(Loss) before tax

Profit/(Loss) before tax multiplied by standard rate of corporation tax in the UK 19.0% (2019: 19.0%)

Effects of:

Expenses not allowable for tax purposes

Enhanced R&D tax relief

Losses surrendered for R&D tax credit

R&D tax credit accrual

Tax losses not previously recognised

Impairment of goodwill and capitalised development

Tax losses utilised

Adjustments in respect of prior years

Impact of change in tax rate

Double tax relief

Other differences

Difference in overseas tax rates 

2020
£000

2,549

(484)

(59)

321

(327)

390

105

-

-

(22)

(102)

(20)

-

(77)

Total income tax charge recognised in consolidated statement of comprehensive income

(275)

2019
£000

(901)

171

34

454

(599)

572

-

(604)

18

(68)

-

110

18

(128)

(22)

8 0

1 1 .   I N T A N G I B L E   A S S E T S

Goodwill
£000

Software 
£000

Intellectual 
property 
£000

Customer 
relationships
£000

Brand 
Names
£000

Patents
£000

Total
£000

Group

Cost

At 1 January 2019

10,590

Additions

Disposals

-

-

Acquisition

2,068

Exchange adjustment

-

At 31 December 2019

12,658

Additions 

Exchange adjustment

-

-

At 31 December 2020

12,658

Amounts written off 

At 1 January 2019

Amortisation expense

-

-

Impairment charge

2,482

Acquisition

Exchange adjustment

-

-

6,840

1,344

(60)

18

(35)

8,107

1,272

34

9,413

2,953

755

693

18

(4)

4,527

2,874

-

-

1,185

-

5,712

-

-

-

-

264

-

3,138

-

-

-

-

-

380

-

380

-

-

5,712

3,138

380

3,040

332

-

-

-

1,427

191

-

-

-

At 31 December 2019

2,482

4,415

3,372

1,618

Amortisation expense

Exchange adjustment

-

-

736

(9)

423

-

212

-

At 31 December 2020

2,482

5,142

3,795

1,830

Net book value

At 31 December 2019

10,176

3,692

At 31 December 2020

10,176

4,271

2,340

1,917

1,520

1,308

-

-

-

-

-

-

29

-

29

380

351

21

24,852

-

-

-

-

21

-

-

21

21

-

-

-

-

21

-

-

21

-

-

1,344

(60)

3,915

(35)

30,016

1,272

34

31,322

7,441

1,278

3,175

18

(4)

11,908

1,400

(9)

13,299

18,108

18,023

The gross carrying amount and accumulated amortisation within Software includes internally generated and externally 
acquired  elements.  The  cost  of  internally  generated  software  amounts  to  £8.6m  (2019:  £7.4m)  with  accumulated 
amortisation of £3.7m (2019: £3.0m).  Software additions for the year include £1.2m relating to internal development 
(2019: £1.3m).

8 1

1 1 .   I N T A N G I B L E   A S S E T S   ( C O N T I N U E D )

Gross carrying amount of goodwill

The allocation of goodwill to Cash Generated Untis (CGUs) is as follows:

Instem LSS Limited

Instem Scientific Limited

Perceptive Instruments Limited

Samarind Limited

Notocord SA

Leadscope Inc

Clinical Holdings Limited

2020
£000

5,900

500

600

600

500

2,100

-

10,200

Acquisition date

27 March 2002

3 March 2011

21 November 2013

27 May 2016

2 September 2016

15 November 2019

2019
£000

5,900

500

600

600

500

2,100

-

10,200

The Goodwill related, to a CGU, being the Instem Clinical Holdings Limited was fully impaired in 2019.

Impairment testing

The Group tests annually for impairment, or more frequently if there are indications that goodwill might be impaired.

Key assumptions

The recoverable amounts of the CGUs are determined from value-in-use calculations. The key assumptions for the 
value in use calculations are those regarding discount rates, growth rates, margins and cashflows.

Discount rates

Management estimates discount rates using pre-tax rates that reflect current market assessments of the time value of 
money and any risks specific to the CGUs. The rates used to discount the future cashflows are based on the Group’s 
pre-tax weighted average cost of capital (WACC) of 9.35% (2019: 10.0%). Management approved the use of the same 
pre-tax WACC across all CGUs,  as it was determined based on the Groups risks and  there were no specific risks 
related  to  each  CGUs  and  CGU’s  jurisdiction.  Additionally,  further  sensitivity  analysis  was  performed  on  pre-tax 
WACC which didn’t lead into any concern.

Growth rates and terminal values

The revenue growth rates and margins are based on current Board-approved budgets and forecasts covering a period 
of five years. The Group produces a budget for 2021 and then forecast up to 2025 based on growth rates of 7% for 
LSS, Instem Scientific and Perceptive Instruments businesses. Then, 5% for Notocord SA and 2.5% for Samarind and 
Clinical Holdings Limited businesses (2019: 2.5% growth rate was applied to all CGUs). 

For the perpetuity calculation (2025 and onwards) the 2.5%, business growth rate was applied to all CGUs which 
management estimates as reasonable considering business growth rates, payroll and other cost base increases (2019: 
2.5% perpetuity growth rate was applied to all CGUs).

A terminal value is calculated using the Gordon Growth Model, to take account of the software development cycle and 
the high percentage of recurring revenues from the customer base.

Sensitivity analysis

Management has carried out sensitivity analyses on the key assumptions used in recoverable amount calculations.  
Instem Clinical and Samarind CGUs were identified as being  sensitive to impairment under the value-in-use model. 
However, using the FV less cost to sell model for the two CGUs it was evidenced that they were not impaired. Notocord 
CGU was also highlighted as sensitive to increases in discount rate and fall in growth rates.

8 2

1 1 .   I N T A N G I B L E   A S S E T S   ( C O N T I N U E D )

The  carrying  amount  includes  goodwill,  other  intangible  assets  and  tangible  assets.  The  headroom  of  recoverable 
amount over carrying amount and sensitivities for 2020 are detailed below:

Recoverable amount 
exceeds the carrying 
amount

Discount rate

Revenue

Instem LSS Limited

Instem Scientific Limited

Perceptive Instruments Limited

Samarind Limited

Notocord SA

Leadscope Inc

Clinical Holdings Limited

923%

1,665%

605%

-

139%

217%

-

67%

149%

38%

-

3%

9%

-

25%

39%

31%

-

5%

15%

-

The recoverable amount of the Instem Clinical CGU and Samarind CGU using the value-in-use calculation did not 
exceed the carrying amount of this CGU. However, using the FV less cost to sell method to calculate the recoverable 
amount  shows  that  the  recoverable  amount  is  more  than  the  carrying  amount  for  both  CGU.  As  the  recoverable 
amount is the higher between value in use and FV less cost to sell method then no impairment charge to be required 
for both CGUs.

Review of carrying value of goodwill

As  of  31  December  2020,  the  recoverable  amount  for  each  of  the  CGU  has  been  measured  using  a  value-in-use 
calculation and no impairment was required with the exception of the Instem Clinical CGU and Samarind CGU. 
However, using the FV less cost to sell method to calculate the recoverable amount shows that the recoverable amount 
is more than the carrying amount for both CGUs. As the recoverable amount is the higher between value in use and 
FV less cost to sell method then no impairment charge is required for either CGU.

As  of  31  December  2019,  a  goodwill  impairment  of  £2.5m  was  recognised  relating  to  the  Instem  Clinical  CGU. 
Alphadas is in the early phase clinical data collection business. This market sector has been going through considerable 
structural change and little new business has been placed in this sector over the last 18 months. We envisage further 
slippage in the pipeline of new opportunities, with no certainty regarding the timing of new business awards. Net 
realisable  value  calculations,  based  on  sales  and  profitability,  were  used  by  the  Group  that  resulted  in  a  goodwill 
impairment of £2.5m in 2019. No further impairment has been deemed necessary in 2020.

The value in use calculations are reliant on the accuracy of management’s forecast and the assumptions that underly 
them as well as the discount rate and growth rates applied.

Other intangible assets

As of 31 December 2020, there were no indications that any other intangible assets may be impaired. 

As  of  31  December  2019,  an  impairment  loss  of  £0.7m  was  recognised  for  internally  developed  software  in  the 
Alphadas early phase clinical data collection business. The recoverable amount of the asset has been determined using 
net realisable value calculations, based on forecast sales and profitability. 

8 3

1 2 .   I N V E S T M E N T S   I N   S U B S I D I A R I E S

Cost

At 1 January 2019

Additions

At 31 December 2019

Additions

At 31 December 2020

Provisions

At 1 January 2019

Additions

At 31 December 2019

Additions

At 31 December 2020

Carrying value

At 31 December 2019

At 31 December 2020

£000

28,927

75

29,002

420

29,422

£000

-

2,810

2,810

(8)

2,802

£000

26,192

26,620

The Company tests annually for impairment against investments held.

An impairment provision of £2.8m has been made in 2019 against the carrying value of the investment in the Alphadas 
early phase clinical data collection business.

At 31 December 2020 the Group had six wholly-owned subsidiaries and twelve wholly-owned sub-subsidiaries, details 
of which are as follows:

Company

Registered Address

Activity

Ownership

Instem Life Science Systems Limited 
(company number 04339129)
England and Wales

Instem LSS Limited 
(company number 03548215)
England and Wales

Instem LSS (North America) Limited 
(company number 02126697)
England and Wales

Instem LSS (Asia) Limited 
(company number 1371107)
Hong Kong

Instem Information Systems (Shanghai) Limited
(company number 310115400257075)
Shanghai, PRC

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Suite 1106-8
11/F Tai Yau Building
No 181 Johnston Road
Wanchai

Room 218, Building 3
No. 690 Bibo Road
Zhanjiang High Tech Park
Pudong District
Shanghai
201203

Holding Company

100% by Instem plc

Software development, 
sales, sales support and 
administrative support

100% by Instem Life Science 
Systems Limited

Sales, sales support and 
administrative support

100% by Instem LSS Limited

Holding Company

100% by Instem LSS Limited

Sales, sales support and 
service

100% by Instem LSS (Asia) 
Limited

8 4

Company

Registered Address

Activity

Ownership

Instem Scientific Limited
(company number 03861669)
England and Wales

Instem Scientific Solutions Limited 
(company number 03598020)
England and Wales

Instem Scientific Inc.
USA

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Leading provider of software 
solutions for extracting 
intelligence from R&D 
related healthcare data

100% by Instem plc

Dormant

100% by Instem Scientific 
Limited

Suite 1550
161 Washington Street
8 Tower Bridge
Conshohocken PA 19428

Leading provider of software 
solutions for extracting 
intelligence from R&D 
related healthcare data

100% by Instem Scientific 
Limited

Instem India Pvt Limited
(company number U73100MH2012FTC231951)
India

Adisa Icon 
Mumbai Bangalore Highway
Bavdhan Budruk
Pune 411021

Instem Clinical Holdings Limited
(company number 05840032)
England and Wales

Instem Clinical Limited
(company number 06959053)
England and Wales

Instem Clinical Inc.
USA

Perceptive Instruments Limited
(company number 02498351)
England and Wales

Instem Japan K.K
(company number 0104-01-120355)
Japan

Samarind Limited
(company number 02105894)
England and Wales

Notocord Systems S.A.
(company number 350927349)
France

Notocord Inc.
USA

Leadscope Inc.
USA

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Suite 1550
161 Washington Street
8 Tower Bridge
Conshohocken PA 19428

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Shinagawa
Intercity Tower, A Level 28
2-15-1 Konan, Minato-ku
Tokyo 108-6028

Diamond Way
Stone Business Park
Stone, Staffordshire
ST15 0SD

Parc des Grillons
60, route de Sartrouville
78230 Le Pecq
Paris

PO Box 10188
Newark
New Jersey
07101-3188

1393 Dublin Road
Columbus
Ohio 43215

99.9% by Instem LSS Limited
0.1% by Instem LSS (NA) 
Limited

100% by Instem plc

100% by Instem Clinical 
Holdings Limited

100% by Instem Clinical 
Holdings Limited

100% by Instem plc

Software development

Holding of intellectual 
property
rights and investment in 
group
companies

Provision of electronic 
data capture and clinical 
management solutions to the 
pharmaceutical industry

Provision of electronic 
data capture and clinical 
management solutions to the 
pharmaceutical industry

Development, manufacture 
and supply of software and 
hardware products for in 
vitro study data collection 
and study management 
in the genetic toxicology, 
microbiology and 
immunology markets 

Sales, sales support and 
service

100% by Instem LSS Limited

Provider of regulatory 
information management 
software

100% by Instem plc

Software development, sales 
support and administrative 
support

100% by Instem plc

Sales, sales support and 
administrative support

100% by Notocord Systems 
S.A.

Leading provider of in-silico 
safety assessment software

100% Instem Scientific Inc

8 5

1 3 .   P R O P E R T Y,   P L A N T   A N D   E Q U I P M E N T

Group

Cost 

At 1 January 2019

Additions

Disposals

Acquisition

Exchange adjustment

At 31 December 2019

Additions

Disposals

Exchange adjustment

At 31 December 2020

Depreciation

At 1 January 2019

Depreciation expense

Disposals

Acquisition

Exchange adjustment

At 31 December 2019

Depreciation expense

Disposals

Exchange adjustment

At 31 December 2020

Net book value

At 31 December 2019

At 31 December 2020

Short leasehold property
£000

IT hardware & software
£000

94

14

(34)

-

(2)

72

13

(4)

1

82

66

7

(33)

-

(1)

39

12

(2)

-

49

33

33

1,544

77

(1)

79

(17)

1,682

128

(32)

(14)

1,764

1,272

148

(1)

75

(16)

1,478

126

(32)

(13)

1,559

204

205

Total
£000

1,638

91

(35)

79

(19)

1,754

141

(36)

(13)

1,846

1,338

155

(34)

75

(17)

1,517

138

(34)

(13)

1,608

237

238

8 6

1 4 .   I N V E N T O R I E S

Group

Work in progress

Total gross inventories

2020
£000

50

50

2020
£000

50

2019
£000

36

36

2019
£000

36

The inventory consists of high-quality industrial-standard cameras and associated hardware for the Instem Sorcerer 
Colony Counter product.

In 2020, a total of £0.02m (2019: £0.02m) of inventory was included in profit or loss as an expense. 

1 5 .   T R A D E   A N D   O T H E R   R E C E I VA B L E S

Group

Trade receivables

Amounts recoverable on contracts

Prepayments and accrued income

Company

Amounts owed by group companies

Other receivables   

2020
£000

3,441

1,825

827

6,093

3,259

71

3,330

2019
£000

4,376

1,365

1,180

6,921

4,861

140

5,001

An allowance has been made for estimated credit losses from trade receivable and amounts recoverable on contracts 
as per below:

An analysis of the provision for impairment of receivables is as follows:

Group

At beginning of year

Increase in provision for impairment

Reversal of provision for impairment

Foreign exchange adjustment

At end of year

2020
£000

215

87

(161)

3

144

2019
£000

54

161

-

-

215

8 7

1 5 .   T R A D E   A N D   O T H E R   R E C E I VA B L E S   ( C O N T I N U E D )

Definition of default

A loss allowance on all financial assets is measured by considering the probability of default.

Receivables are considered to be in default based on an assessment of past payment practices over a 5 year period prior 
to 31 December 2020 and the likelihood of such overdue amounts being recovered. 

Impairment of trade receivables

The probability of default is determined at the year-end based on the ageing of the receivables and historical data 
about  default  rates. That  data  is  adjusted  if  the  Group  determines  that  historical  data  is  not  reflective  of  expected 
future conditions due to changes in the nature of its customers and how they are affected by external factors such as 
economic and market conditions.

The calculated simplified expected credit loss of trade receivables is deemed immaterial in the current year (2019: 
immaterial). The directors therefore do not deem it necessary to increase the impairment provision which is in relation 
to specific credit-impaired receivables.

The average credit period taken on sale is 51 days (2019: 61 days). No interest has been charged on overdue receivables.

Before accepting any new significant customer, the Group obtains relevant credit references to assess the potential 
customer’s credit quality. Credit limits are defined by customer.

The directors consider that the carrying amount of trade and other receivables approximates to their fair value.

Impairment of amounts owed by group companies

The Company assesses the expected credit loss in respect of group receivables based on their ability to repay and recover 
the balance.  In the absence of agreed terms this consideration is given over the expected period of repayment and any 
expected credit loss. As at the period end the Company has reversed a provision of £0.6m for credit impairment of 
amounts owed by group companies (2019: has made a provision of £0.8m).  The amount of the provision was £0.2m 
as of 31 December 2020 (2019: £0.8m). 

The age profile of the net trade receivables for the Group at the year-end was as follows:

Debt age

Group
2020

Current

0-30 days

31-60 days

Trade receivables/Amounts recoverable on contracts

Value (£000)

4,132

%

78

556

11

251

5

Debt age

Group
2019

Current

0-30 days

31-60 days

Trade receivables/Amounts recoverable on contracts

Value (£000)

3,654

1,063

%

64

18

451

8

Over 60 
days

327

6

Over 60 
days

573

10

Total

5,266

100

Total

5,741

100

The maximum exposure to credit risk at the reporting date is the carrying value of each class of receivables mentioned 
above. The Group does not hold any collateral as security.

8 8

1 6 .   C A S H   A N D   C A S H   E Q U I VA L E N T S

Group

Cash at bank

Bank overdraft 

Company

2020
£000

35,722

(8,998)

26,724

2019
£000

14,955

(8,998)

5,957

Cash at bank

20,269

1,128

Cash and cash equivalents at 31 December 2020 includes the gross proceeds of £15.75m (£15.0m net of expenses) 
raised through a placing of 3,620,690 new shares at a price of 435p per share, announced by the Group on 26 June 
2020.

The Group’s overdraft facility has a net limit of £0.5m and a gross limit of £9.0m.  Interest is charged on the bank 
overdraft at 3.0% above base rate.  The bank overdraft is secured by fixed and floating charges over certain of the 
Group’s assets and is repayable on demand.

Cash and cash equivalents in the statement of financial position includes a bank overdraft of £9.0m (2019: £9.0m) as 
noted above. An offset position is reported as the Group has a legal right to offset any settlement would be on a net 
basis.

There is a debenture in favour of National Westminster Bank Plc, dated 13 April 2011, secured over the assets of the 
Group by way of fixed and floating charges, in respect of the Group’s overdraft facility.

An analysis of cash and cash equivalents by currency is as follows:

Group

Sterling

Euro

US Dollar

Renminbi

Other

Company

Sterling

US Dollar

2020
£000

9,312

1,044

12,326

2,562

1,480

26,724

11,197

9,072

20,269

2019
£000

355

737

1,535

1,924

1,406

5,957

1,128

-

1,128

The carrying amount of these assets approximates to their fair value. 

8 9

1 7 .   T R A D E   A N D   O T H E R   P A YA B L E S

Group - Current

Trade payables

Other taxation and social security costs

Accruals

Company - Current

Trade payables

Amounts owed to group companies

Accruals

2020
£000

466

533

1,959

2,958

67

7,979

422

8,468

2019
£000

912

183

1,567

2,662

275

6,051

333

6,659

The directors consider that the carrying amount of trade and other payables approximates to fair value due to their 
short maturities. 

1 8 .   D E F E R R E D   I N C O M E                    

Consideration received from customers in advance of work being completed 
plus maintenance and support which is invoiced in advance

2020
£000

9,878

2019
£000

8,942

9 0

  
1 9 .   F I N A N C I A L   L I A B I L I T I E S

An analysis of financial liabilities as presented in the statement of financial position is as follows:

Lease liability

Deferred consideration

Current liability

Non current borrowings

Deferred consideration

Contingent consideration

Non current liability

2020
£000

-

268

268

2020
£000

815

-

316

1,131

2019
£000

18

283

301

2019
£000

-

275

284

559

The  deferred  consideration  and  contingent  consideration  above  is  in  respect  of  the  acquisition  of  Leadscope  Inc, 
which was purchased on 15 November 2019.

The financial liability maturity analysis is disclosed in the table below.

2020

1 year or less
£000

1 to 2 years
£000

2 to 5 years
£000

Non current borrowings

Deferred consideration

Contingent consideration

-

268

-

268

815

-

316

1,131

-

-

-

-

2019

1 year or less
£000

1 to 2 years
£000

2 to 5 years
£000

Lease liability

Deferred consideration

Contingent consideration

18

283

-

301

-

275

-

275

-

-

284

284

Total
£000

815

268

316

1,399

Total
£000

18

558

284

860

9 1

2 0 .   F I N A N C I A L   I N S T R U M E N T S

FAIR VALUES OF FINANCIAL INSTRUMENTS

Fair values

The table below analyses financial instruments into a fair value hierarchy based on the valuation technique used to 
determine fair value.

Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities. 

Level 2: Inputs other than quoted prices included within Level 1 that are observable for the asset or liability, either 
directly (i.e. as prices) or indirectly (i.e. derived from prices).

Level 3: Inputs for the asset or liability that are not based on observable market data (unobservable input).

2020
Group and Company

Carrying amount
£000

Fair value
£000

Contingent consideration

316

316

2019
Group and Company

Carrying amount
£000

Contingent consideration

284

Fair value
£000

284

Level 3
£000

316

Level 3
£000

284

Measurement of fair value of financial instruments

The following valuation technique is used is used for instruments categorised as Level 3:

Contingent consideration (Level 3) – the fair value of contingent consideration related to the acquisition of Leadscope 
Inc in November 2019 was estimated using a present value technique. The £284,000 fair value was estimated in 2019 by 
probability weighting the estimated future cash outflows, adjusting for risk and discounting at 13.4%. The probability 
weighted cash outflows before discounting are £388,000 and reflect management’s estimate of a 100% probability that 
the Leadscope’s target level of profitability will be achieved. 

The reconciliation of the carrying amounts of financial instruments classified as Level 3 is as follows:

Balance as at 1 January 

Arising on business combination

Payment of contingent consideration

Unwinding discount

Foreign exchange

Balance as at 31 December

2020
£000

284

-

-

52

(20)

316

2019
£000

-

284

-

-

-

284

9 2

2 0 .   F I N A N C I A L   I N S T R U M E N T S   ( C O N T I N U E D )

The Group is exposed to various risks in relation to financial instruments. Each of these is disclosed in the table below.

Carrying 
amount
2020
£000

Fair value 
2020
£000

Level 3 
2020
£000

Carrying 
amount
2019
£000

Fair value 
2019
£000

Level 3 
2019
£000

Loans and receivables

Cash and cash equivalents

26,724

Trade and other receivables

6,093

Financial assets measured at amortised cost

32,817

Financial assets measured at fair value

-

26,724

6,093

32,817

-

Total financial assets

32,817

32,817

Financial liabilities measured at amortised cost 

Trade payables and accruals

(2,425)

Financial liabilities measured at amortised cost

(2,425)

Contingent consideration

Financial liabilities measured at fair value

(316)

(316)

(2,425)

(2,425)

(316)

(316)

-

-

-

-

-

-

-

(316)

(316)

5,957

6,921

5,957

6,921

12,878

12,878

-

-

12,878

12,878

(2,479)

(2,479)

(284)

(284)

(2,479)

(2,479)

(284)

(284)

-

-

-

-

-

-

-

(284)

(284)

Total financial liabilities

(2,741)

(2,741)

(2,763)

(2,763)

Total financial instruments

30,076

30,076

10,115

10,115

CREDIT RISK

Financial risk management

Management aims to minimise the risk of credit losses.

The Group’s financial assets are bank balances and cash and trade and other receivables, which represent the Group’s 
maximum exposure to credit risk in relation to financial assets.

The Group’s credit risk is primarily attributable to its trade receivables and the Group has policies in place to ensure 
that sales of products and services are made to customers with appropriate creditworthiness. The Group generates 
external revenue from no customer that individually amounts to more than 10% of the Group revenue. At the 2020 
year end the Group had a maximum credit risk exposure of £6.1m (2019: £6.9m).

The amounts presented in the statement of financial position are net of impairment provisions.

The Group’s exposure to losses from defaults on trade receivables is reduced due to contractual terms which require 
installation, training, annual licensing and support fees to be invoiced and paid annually in advance. Note 15 sets out 
the impairment provision for credit losses on trade receivables and the ageing analysis of overdue trade receivables. 
There were no impairment losses recognised on other financial assets.

The Group undertakes procedures to determine whether there has been a significant increase in the credit risk of 
its  other  receivables,  including  group  balances,  since  their  initial  recognition.    Where  these  procedures  identify  a 
significant increase in credit risk, the loss allowance is measured based on the risk of a default occurring over the 
expected life of the instrument rather than considering only the default events expected within 12 months of the year-
end.

9 3

2 0 .   F I N A N C I A L   I N S T R U M E N T S   ( C O N T I N U E D )

The concentration of credit risk for trade receivables at the balance sheet date by geographical region was:

UK 

Europe

USA 

China

Rest of World

2020
£000

319

778

1,823

386

135

3,441

2019
£000

1,766

146

1,401

644

419

4,376

LIQUIDITY RISK 

Financial risk management

Liquidity risk is the risk that the Group will not be able to meet its financial commitments as they fall due.

The Group’s objective is to ensure that adequate facilities are available through use of bank overdrafts and leases.  The 
Group manages liquidity risk through regular cash flow forecasting and monitoring of cash flows, management review 
and regular review of working capital and costs.

The Group regularly monitors its available headroom under its borrowing facilities.  At 31 December 2020, its £0.5m 
bank facility was undrawn (2019: £0.5m undrawn). The Group had positive cash reserves of £27m at the 2020 year 
end, in addition to the £0.5m undrawn working capital facility, although £2.5m of the cash was held in bank accounts 
in China, where it has been traditionally harder to repatriate funds quickly. There are no long term restrictions on the 
transfer of funds from the Group bank accounts in China.

The following are the contractual maturities of financial liabilities.

2020
Non derivative financial liabilities

Carrying 
amount
£000

Contractual 
cashflows
£000

1 year or less
£000

2 to 5 years 
£000

After 5 years
£000

Liabilities relating to right of use assets

2,084

Non current borrowings

Trade payables

815

466

3,365

2,084

815

466

3,365

488

-

466

954

1,538

815

-

2,353

58

-

-

58

2019
Non derivative financial liabilities

Carrying 
amount
£000

Contractual 
cashflows
£000

1 year or less
£000

2 to 5 years 
£000

After 5 years
£000

Liabilities relating to right of use assets

2,569

Lease liabilities

Trade payables

18

912

3,499

2,569

18

912

3,499

565

18

912

1,950

-

-

1,495

1,950

54

-

-

54

9 4

2 0 .   F I N A N C I A L   I N S T R U M E N T S   ( C O N T I N U E D )

MARKET RISK

Market risk - Foreign currency risk

The Group operates internationally and is exposed to foreign currency risk on transactions denominated in a currency 
other  than  the  functional  currency  and  on  the  translation  of  the  statement  of  financial  position  and  statement  of 
comprehensive income of foreign operations into sterling.  The currencies giving rise to this risk are primarily US 
dollars.  The Group has both cash inflows and outflows in this currency that create a natural hedge.  

In  managing  currency  risks  the  Group  aims  to  reduce  the  impact  of  short-term  fluctuations  on  the  Group’s  cash 
inflows and outflows in a foreign currency.  

Over the longer  term, changes in foreign  exchange could have an  impact  on consolidation of foreign subsidiaries 
earnings.  A 10% decrease in the average value of Sterling against the US dollar would have resulted in an increase in 
the Group’s profit before tax by approximately £0.1m (2019: £0.1m).

The Group’s exposure to foreign currency risk is as follows.

2020

Sterling
£000

Cash and cash equivalents

9,312

Trade and other receivables

932

Liabilities relating to right off use assets

(519)

Non current borrowings

-

Trade payables

(191)

Euro
£000

1,044

753

(289)

-

(56)

US Dollars
£000

Renminbi
£000

12,326

2,562

3,320

(646)

(815)

(223)

679

(1)

-

-

Other
£000

1,480

409

(629)

-

4

Total
£000

26,724

6,093

(2,084)

(815)

(466)

Net exposure

9,534

1,452

13,962

3,240

1,264

29,452

2019

Sterling
£000

Cash and cash equivalents

Trade and other receivables

Liabilities relating to right off use assets

Lease liabilities

355

2,804

(666)

(18)

Trade payables

(574)

Net exposure

1,901

Euro
£000

737

188

(309)

-

(14)

602

US Dollars
£000

Renminbi
£000

1,924

716

(16)

-

-

1,535

2,636

(730)

-

(330)

3,111

Other
£000

1,406

577

(848)

-

6

2,624

1,141

Total
£000

5,957

6,921

(2,569)

(18)

(912)

9,379

Interest rate risk 

The  Group  operates  an  interest  rate  policy  designed  to  minimise  interest  costs  and  reduce  volatility  in  reported 
earnings.

The Group’s bank facility does not allow the US Dollar cash balances to generate interest therefore the Group transfers 
funds from the US dollar account into the sterling account.  Currency transfers have been utilised to maximise the 
interest gains whilst minimising foreign exchange risks.

As at 31 December 2020, the indications are that the UK bank base interest rate will not materially differ over the next 
12 months.  On the basis of the net cash position at 31 December 2020 and assuming no other changes occur (such 
as material changes in currency exchange rates) a change in interest rates should not have a material impact on net 
interest income/(expense). 

9 5

2 1 .   C U R R E N T   T A X A T I O N

The Group current tax receivable is £0.7m, net of a payable of £0.2m (2019: receivable of £1.2m and payable of 
£0.4m) representing the amount of income tax receivable and payable in respect of the current and prior years.

The Company current tax payable is £nil.

2 2 .   D E F E R R E D   T A X

Group

Deferred tax asset

Amounts due to be recovered after 12 months

Total deferred tax liability

The movement in the year in the Group’s net deferred tax position was as follows:

At beginning of the year

Foreign exchange differences

Net charge to income for the year

Net debit to Other Comprehensive Income (OCI)

Net debit to goodwill arising on acquisitions during the year

Adjustments in respect of prior years 

At end of the year

2020
£000

(90)

(90)

2020
£000

(506)

(10)

(357)

840

-

(57)

(90)

2019
£000

(506)

(506)

2019
£000

(12)

-

(166)

(6)

(311)

(11)

(506)

The following are the major deferred tax assets and liabilities recognised by the Group and the movements thereon 
during the year:

Deferred tax asset/(liability)

Accelerated 
tax 
depreciation
£000

Tax losses
£000

Retirement 
benefit 
obligations
£000

Other timing 
differences
£000

At 1 January 2019

(526)

Credit/(charge) to profit or loss for the year

Debit to OCI for the year

116

-

Debit to goodwill arising on acquisitions during the year

(311)

Adjustments in respect of prior years

-

At 31 December 2019

(721)

Foreign exchange differences

Credit/(charge) to profit or loss for the year

Debit to OCI for the year

Debit to goodwill arising on acquisitions during the year

Adjustments in respect of prior years

-

34

-

-

(4)

At 31 December 2020

(691)

437

(42)

-

-

-

395

-

(126)

-

-

(60)

209

383

(70)

(6)

-

-

307

-

(90)

518

-

-

(306)

(181)

-

-

-

(487)

(10)

(175)

322

-

7

735

(343)

Total
£000

(12)

(177)

(6)

(311)

-

(506)

(10)

(357)

840

-

(57)

(90)

9 6

2 2 .   D E F E R R E D   T A X   ( C O N T I N U E D )

Analysis of P&L deferred tax movement

Current year movement

Impact of rate change-P&L

Total P&L for year (see above)

Analysis of OCI deferred tax movement

Accelerated 
tax 
depreciation
£000

119

(85)

34

Accelerated 
tax 
depreciation
£000

Current year movement

Impact of rate change-P&L

Total OCI for year (see above)

-

-

-

Tax losses
£000

(165)

39

(126)

Tax losses
£000

-

-

-

Retirement 
benefit 
obligations
£000

Other timing 
differences
£000

(90)

-

(90)

(119)

(56)

(175)

Retirement 
benefit 
obligations
£000

Other timing 
differences
£000

482

36

518

322

-

322

Total
£000

(255)

(102)

(357)

Total
£000

804

36

840

Management have recognised deferred tax assets in relation to tax losses based on forecast profitability of the Group 
companies concerned.

Unrecognised tax losses not included at 31 December 2020 were £2.7m (2019: £0.2m) due to uncertainty over the 
timing of the recoverability of these losses.

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S

The Group has five active defined contribution schemes and a closed defined benefit scheme:

Defined contribution pension schemes

GROUP PERSONAL PENSION PLAN - the Scheme was created on 31 December 2008.  The Scheme is a contributory 
money purchase scheme with the employer matching employee contributions to a maximum of 5%.  The employer 
also contributes to the Scheme for former members of Instem LSS Pension Scheme at rates varying from 5% to 18%.  
Employer contributions for the year ended 31 December 2020 were £0.66m (2019: £0.65m).

CONTRACTED IN MONEY PURCHASE SCHEME (CIMP) - the Scheme was created on 31 December 2008.  The 
Scheme is a non-contributory scheme created for former members of the Instem LSS Pension Scheme who are US 
residents.  Employer contributions for the year ended 31 December 2020 were £0.03m (2019: £0.03m).

INSTEM  LSS  (NORTH  AMERICA)  LIMITED  401K  PLAN  -  the  Plan  was  created  for  the  benefit  of  employees 
of Instem LSS (North America) Limited in the USA.  The Plan is a contributory money purchase scheme with the 
employer matching contributions to the scheme to a maximum of 4.8%.  Employer contributions for the year ended 
31 December 2020 were £0.23m (2019: £0.18m).

LEADSCOPE INC 401K PLAN - the Plan was created for the benefit of employees of Leadscope Inc in the USA. 
The Plan is a defined contribution plan within the scope of IRS regulations, with employer matching contributions of 
3% of compensation. Employer contributions for the year ended 31 December 2020 were £0.019m (2019: £0.002m). 
Leadscope was acquired by Instem on 15 November 2019.

BIOWISDOM GPP SCHEME - the Scheme is a Group Personal Pension arrangement with AVIVA set up in 2001.  
Employee members must contribute at least 3% of basic salary and the employer contributes up to a maximum of 
6%.  This scheme closed during 2020 and members transferred to the main Group Personal Pension Plan. Employer 
contributions for the year ended 31 December 2020 were £0.01m (2019: £0.01m).

9 7

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S   ( C O N T I N U E D )

Defined benefit pension scheme

The Group also operates a defined benefit pension arrangement called the Instem LSS Pension Scheme (the Scheme). 
The Scheme provides benefits based on final salary and length of service on retirement, leaving service or death. This 
scheme was closed to new members with effect from 8 October 2001. 

The Scheme is subject to the Statutory Funding Objective under the Pensions Act 2004. A valuation of the Scheme 
is carried out at least once every three years to determine whether the Statutory Funding Objective is met. As part of 
the process, the Group must agree with the Trustees of the Scheme the contributions to be paid to meet the Statutory 
Funding Objective. The future contributions required to meet the Statutory Funding Objective do not currently affect 
the statement of financial position of the Scheme in these accounts. 

The most recent comprehensive actuarial valuation of the Scheme was carried out as at 5 April 2017 and the next 
valuation of the Scheme is due as at 5 April 2020. In the event that the valuation reveals a larger deficit than expected 
the Group may be required to increase contributions above those set out in the existing Schedule of Contributions. 
Conversely, if the position is better than expected, it is possible that contributions may be reduced. 

The Group currently expects to pay contributions of £530,000 in the year to 31 December 2021.

The Scheme is managed by a Board of Trustees appointed in part by the Group and part from elections by members of 
the Scheme. The Trustees have responsibility for obtaining valuations of the Scheme, administering benefit payments 
and investing the Scheme’s assets. The Trustees delegate some of these functions to their professional advisors where 
appropriate.

The Scheme exposes the Group to a number of risks: 

• 

• 

• 

Investment risk. The Scheme holds investments in asset classes, such as equities, which have volatile market values 
and while these assets are expected to provide the real returns over the long-term, the short-term volatility can 
cause additional funding to be required if a deficit emerges.

Interest  rate  risk. The  Scheme’s  liabilities  are  assessed  using  market  yields  on  high  quality  corporate  bonds  to 
discount the liabilities. As the Scheme holds assets such as equities the value of the assets and liabilities may not 
move in the same way.

Inflation risk. A significant proportion of the benefits under the Scheme are linked to inflation. Although the 
Scheme’s assets are expected to provide a good hedge against inflation over the long-term, movements over the 
short-term could lead to deficits emerging.

•  Mortality risk. In the event that members live longer than assumed a deficit will emerge in the Scheme.

There were no Scheme amendments, curtailments or settlements during the year.

A further judgment on The Lloyds Banking Group Pensions Trustees Limited v Lloyds Bank PLC (and others) case 
was made on 20 November 2020 and covered whether schemes are required to revisit past transfers. The guaranteed 
minimum pensions (GMP) equalisation judgment has resulted in an additional liability of £5,000 being recognised at 
31 December 2020, and this has been allowed for as a profit and loss charge, within non recurring costs.

The employer pays the Pension Protection Fund levy each year in respect of the scheme.  It is intended that all other 
expenses associated with the running of the Scheme will be met from the Scheme’s assets.

Risk mitigation strategies

The investment manager has previously been instructed as to the permissible ranges for asset allocations as set out in 
the Scheme’s current Statement of Investment Principles. Over the year, the Scheme invested in a portfolio of liability-
driven assets, designed to hedge against interest rate and inflation risk.

9 8

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S   ( C O N T I N U E D )

The net interest on the net defined benefit liability was determined by considering the expected returns available on 
the  assets  underlying  the  current  investment  portfolio.    Expected  yields  on  bonds  are  based  on  gross  redemption 
yields at the reporting date whilst the expected returns on the equity and property investments reflect the long-term 
real rates of return experienced in the respective markets.  

Discount rate (pa)

Inflation (RPI pa)

Inflation (CPI pa)

Pension increase (RPI pa)

Pension increase (CPI pa)

2020
%

1.40

2.70

1.90

2.70

1.80

Life Expectancy assumption (number of years from the age of 65)

Years

Male currently aged 45

Female currently aged 45

Male currently aged 65

Female currently aged 65

ANALYSIS OF AMOUNT CHARGED TO FINANCE COSTS

Interest on pension scheme assets

Interest on pension scheme liabilities

Net finance charge

ANALYSIS OF AMOUNT RECOGNISED IN OTHER COMPREHENSIVE INCOME/
(EXPENSE)

Gains on assets in excess of interest

Experience losses on liabilities

(Losses)/gains from changes to demographic assumptions 

23.8

25.0

22.8

23.7

2020
£000

266

(300)

(34)

2020
£000

-

(351)

(53)

Losses from changes to financial assumptions                                               

(2,133)

Actuarial (losses)/gains recognised in other comprehensive income/(expense)

(2,537)

2019
%

2.20

2.80

1.80

2.70

1.70

Years

23.7

24.8

22.7

23.6

2019
£000

316

(376)

(60)

2019
£000

1,003

-

261

(1,234)

30

9 9

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S   ( C O N T I N U E D )

CHANGES IN THE PRESENT VALUE OF THE DEFINED BENEFIT OBLIGATION

2020
£000

Opening defined benefit obligation

13,773

Interest cost

Past service cost and GMP reserve

Benefits paid

Experience loss on liabilities

Changes to demographic assumptions

Changes to financial assumptions

300

5

(235)

351

53

2,133

2019
£000

12,655

376

-

(231)

-

(261)

1,234

Closing defined benefit obligation

16,380

13,773

CHANGES IN THE FAIR VALUE OF PLAN ASSETS

2020
£000

Opening plan assets

11,969

Interest on assets

Return on plan assets less interest

Company contributions

266

-

512

Benefits paid

(235)

Closing plan assets

12,512

The actual return on assets was a positive return of £266,000 (2019: positive return £1,319,000).

AMOUNT RECOGNISED IN THE CONSOLIDATED STATEMENT OF FINANCIAL 
POSITION

2020
£000

Present value of funded obligations

(16,380)

Fair value of plan assets

Net pension liability

Related deferred tax asset

12,512

(3,868)

735

Net pension liability after deferred tax

(3,133)

2019
£000

10,406

316

1,003

475

(231)

11,969

2019
£000

(13,773)

11,969

(1,804)

307

(1,497)

1 0 0

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S   ( C O N T I N U E D )

RECONCILIATION OF NET DEFINED BENEFIT LIABILITY

Net defined benefit liability at start

Past service cost and GMP reserve

Net interest expense 

Remeasurements

Employer contributions

Net defined benefit liability at end

2020
£000

1,804

5

34

2,537

(512)

3,868

2019
£000

2,249

-

60

(30)

(475)

1,804

ANALYSIS OF CUMULATIVE AMOUNT RECOGNISED IN OTHER COMPREHENSIVE 
INCOME/(EXPENSE)

Cumulative
2020
£000

Cumulative
2019
£000

Actual return less expected return on assets

Experience losses on liabilities

Changes in demographic assumptions

Changes in financial assumptions 

Cumulative actuarial loss recognised in the OCI

2,094

(1,979)

562

(6,555)

(5,878)

Actuarial (loss)/gain recognised in the OCI in the period

(2,537)

2,094

(1,628)

615

(4,422)

(3,341)

30

MAJOR CATEGORIES OF PLAN ASSETS AS A PERCENTAGE OF FAIR VALUE OF TOTAL PLAN ASSETS

2020

2019

Equities

Property

Bonds

Corporate Bonds

LDI

Cash

Other

£000

5,842

717

858

2,033

994

122

1,946

%

47

6

7

16

8

1

15

£000

7,277

655

1,109

1,799

-

338

791

%

61

5

9

15

-

3

7

12,512

100

11,969

100

1 0 1

2 3 .   R E T I R E M E N T   B E N E F I T   O B L I G A T I O N S   ( C O N T I N U E D )

The five-year history of experience adjustments is as follows:

2020
£000

2019
£000

2018
£000

2017
£000

2016
£000

Present value of defined benefit obligation

(16,380)

(13,773)

(12,655)

(14,549)

(14,436)

Fair value of plan assets

12,512

11,969

10,406

10,799

9,690

Deficit

(3,868)

(1,804)

(2,249)

(3,750)

(4,746)

Experience (losses)/gains on liabilities

(351)

Return on plan assets less interest

-

-

1,003

65

(957)

156

686

-

1,252

The following sensitivities apply to the value placed on the liabilities:

Adjustments to assumptions
Approximate effect on liabilities

DISCOUNT RATE

+ 0.50% pa

- 0.50% pa

INFLATION

+ 0.50% pa

- 0.50% pa

MORTALITY

Life expectancy + 1 year

Life expectancy - 1 year 

£000

(1,331)

1,511

1,299

(1,160)

469

(446)

2 4 .   P R O V I S I O N   F O R   L I A B I L I T I E S

At 1 January

Increase in provision during the year

At 31 December

2020
£000

250

-

250

2019
£000

250

-

250

The Group holds a provision of £0.25m (2019: £0.25m) in respect of historical contract disputes against a maximum 
exposure of approximately £4.0m (2019: £1.5m). The maximum exposure has increased since last year end due to 
additional claims for consequential losses. There are uncertainties around the outcome of contract disputes and any 
settlements may be higher or lower than the amount provided. The directors believe the provision represents the best 
estimate of  the  risks  and considers  all information and legal input received by the Group. The assumptions made 
in relation to the current period are consistent with those in the prior year. The utilisation of this provision is still 
expected to happen within two years due to the legal process taking longer than originally anticipated.  

1 0 2

2 5 .   S H A R E   C A P I T A L

The share capital of Instem plc consists only of fully paid ordinary shares with a nominal value of 10p per share.

SHARES ISSUED AND FULLY PAID:

2020
£000

2019
£000

Beginning of the year

16,623,078

15,917,931

Issued on exercise of employee share options

238,141

Share issue on acquisition of Leadscope Inc

-

Share issue, placing

3,620,690

473,181

231,966

-

Total shares issued and fully paid at 31 December

20,481,909

16,623,078

Additional shares were issued during 2020 relating to share-based payments (see note 9 for details on the Group’s 
share-based remuneration).

On 26 June 2020, the Group announced the issue of 3,620,690 new shares through a placing to raise funds to support 
acquisition activities, corresponding to 22% of total shares issued.

In addition the Group launched an all-staff share and option scheme, with staff receiving the right to 386,686 ordinary 
shares of 10p each in the Company that will vest in April 2023.

Share premium

Proceeds received in addition to the nominal value of the shares issued during the year have been included in share 
premium, less fees, commissions and disbursements. Costs of new shares charged to equity amounted to £0.7m (2019: 
£nil).

Share premium has also been recorded in respect of the issue of share capital related to employee share-based payment.

2 6 .   E A R N I N G S   P E R   S H A R E

Basic and diluted earnings per share
Basic earnings per share are calculated by dividing the profit attributable to ordinary shareholders by the weighted 
average number of ordinary shares in issue during the year.  Diluted earnings per share is calculated by adjusting the 
weighted number of ordinary shares outstanding to assume conversion of all dilutive potential shares arising from the 
share option scheme.  The dilutive impact of the share options is calculated by determining the number of shares that 
could have been acquired at fair value (determined as the average market share price of the Company’s shares) based 
on the monetary value of the subscription rights attached to the outstanding share options. The diluted loss per share 
in 2019 is the same as basic loss per share with losses having an anti-dilutive effect.

Profit after tax 
(£000)

Earnings per share - Basic

2,274

Potentially dilutive shares

-

Earnings per share - Diluted

2,274

2020

Weighted 
average 
number of 
shares (000’s)

18,421

1,231

19,652

Profit per 
share (pence)

Loss after tax 
(£000)

12.3

-

11.6

(923)

-

(923)

2019

Weighted 
average 
number of 
shares (000’s)

16,254

799

17,053

Loss per share 
(pence)

(5.7)

-

(5.7)

1 0 3

2 6 .   E A R N I N G S   P E R   S H A R E   ( C O N T I N U E D )

Adjusted earnings per share

Adjusted earnings per share is calculated after adjusting for the effect of foreign currency exchange on the revaluation of 
inter-group balances included in finance income/(costs), non-recurring items, impairment of goodwill and capitalised 
development and amortisation of intangibles on acquisitions. Diluted adjusted earnings per share is calculated by 
adjusting the weighted number of ordinary shares outstanding to assume conversion of all dilutive potential shares 
arising  from  the  share  option  scheme.    The  dilutive  impact  of  the  share  options  is  calculated  by  determining  the 
number of shares that could have been acquired at fair value (determined as the average market share price of the 
Company’s shares) based on the monetary value of the subscription rights attached to the outstanding share options.

Adjusted 
profit after tax 
(£000)

Earnings per share - Basic

3,752

Potentially dilutive shares

-

Earnings per share - Diluted

3,752

2020

Weighted 
average 
number of 
shares (000’s)

18,421

1,231

19,652

20.4

-

19.1

Adjusted 
earnings per 
share (pence)

Adjusted profit 
after tax (£000)

2019

Weighted 
average 
number of 
shares (000’s)

16,254

799

17,053

Adjusted 
earnings per 
share (pence)

19.3

-

18.4

2019
£000

(901)

302

523

3,175

61

3,160

(22)

3,138

(923)

3,138

-

3,138

2020
£000

2,549

606

664

-

208

4,027

(275)

3,752

2,274

Reconciliation of adjusted profit before tax:

Reported profit/(loss) before tax

Non-recurring costs

Amortisation of acquired intangibles

Impairment of goodwill and capitalised development costs

Foreign exchange differences on revaluation of inter-group balances

Adjusted profit before tax

Tax

Adjusted profit after tax

Profit/(loss) after tax

2 7 .   C A P I T A L   A N D   R E S E R V E S

Share capital

The share capital account represents the par value for all shares issued.  The Company has one class of share and each 
share rank parri passu and carry equal rights.

Share premium account

The share premium account is used to record amounts received in excess of the nominal value of shares on issue of 
new shares less the costs of new share issues.

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2 7 .   C A P I T A L   A N D   R E S E R V E S   ( C O N T I N U E D )

Merger reserve

The merger reserve represents -

• 

• 

the difference between the consideration payable at the date of acquisition, net of merger relief, and the share 
capital and share premium of Instem Life Science Systems Limited and

the difference between the nominal value and share issue price of shares issued as consideration in the purchase 
of Leadscope Inc

Share based payment reserve

The share based payment reserve represents the fair value of shares options periodically awarded to employees and 
executive directors, which is charged to the statement of comprehensive income.

Translation reserve

The translation reserve incorporates the cumulative net exchange gains and losses recognised on the translation of 
subsidiary company financial information to the presentational currency of Sterling (£). 

Retained earnings

The retained earnings reserve includes the accumulated profits and losses arising from the consolidated ‘Statement of 
Comprehensive Income’ and certain items from ‘Other Comprehensive Income’ attributable to equity shareholders 
net of distributions to shareholders.

Capital management

The Group’s main objective when managing capital is to protect returns to shareholders by ensuring the Group will 
continue to trade profitably in the foreseeable future.  The Group also aims to maximise the capital structure of debt 
and equity so as to minimise its cost of capital. The Group manages its capital with regard to the risks inherent in the 
business and the sector within which it operates by monitoring its gearing ratio on a regular basis. 

The Group considers its capital to include share capital, share premium, merger reserve, share based payment reserve, 
translation reserve, retained earnings and net debt as noted below. 

Net debt includes short and long-term borrowings (including overdrafts and lease obligations) net of cash and cash 
equivalents.  

The Group has not made any changes to its capital management during the year.

2 8 .   C A P I T A L   C O M M I T M E N T S

There were no capital commitments at the end of the financial year (2019: £nil).

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2 9 .   R E L A T E D   P A R T Y   T R A N S A C T I O N S

Transactions between Group companies have not been disclosed as these have all been eliminated in the preparation 
of the consolidated financial statements. During the year, the Group traded with subsidiary companies in its normal 
course of business. These transactions related to recharges and totalled in aggregate £1.0m (2019: £1.0m).  The net 
intercompany balances due from the Company at the year-end totalled £4.5m (2019: due from: £0.3m).

During the year, the Group traded in its normal course of business with shareholders and consultancy businesses in 
which Directors have a material interest as follows:

KEY MANAGEMENT COMPENSATION:

2020
£000

2019
£000

Group and Company

Fees for services provided as Non-Executive Directors

Salaries and short-term benefits

Employer's national insurance & social security costs

Group

Executive Directors

Salaries and short-term benefits

Post-employment retirement benefits

Employers’ national insurance & social security costs

Share based payment charge

138

15

153

385

44

34

98

561

Group

Other key management

Salaries and short-term employee benefits

1,062

Post-employment retirement benefits

Employers’ national insurance & social security costs

Share based payment charge

77

74

154

1,367

120

13

133

359

43

29

21

452

1,047

59

99

54

1,259

The Company paid £0.05m (2019: £0.05m) to Instem Ventures Limited, a company owned by A Gare, a shareholder.  
The balance outstanding at the end of the year was £nil (2019: £nil).

Key management are considered to be the Directors together with the Senior Managers of the business. 

3 0 .   C O N T I N G E N T   L I A B I L I T I E S

Instem  plc  has  provided  a  guarantee  to  its  subsidiaries  which  have  taken  advantage  of  the  exemption  from  audit.  
Under this guarantee, the company has a contingent liability of £16.4m (2019: £9.0m).

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3 1 .   S U B S E Q U E N T   E V E N T S

No adjusting events have occurred between the 31 December reporting date and the date of approval of these financial 
statements.

On  25  of  January  2021,  Instem  Information  Systems  (Shanghai)  Limited  signed  a  new  office  lease  for  2  years  in 
Pudong New Area, Shanghai.

On 1 March 2021, Instem announced the acquisition of The Edge Software Consultancy Ltd (“The Edge”), a safety 
assessment software provider based in the UK. The Edge is focused on improving the efficiency of early stage drug 
R&D, improving productivity and ensuring high-quality data capture. In the year ended 31 July 2020, The Edge had 
unaudited, normalised profits before tax of £1.7m on sales of £2.7m, of which £0.8m was recurring revenue. Its 2020 
sales benefitted from high levels of professional services revenue, expected to be replaced by significant future growth 
in recurring software revenue. The consideration payable is up to £8.5m , payable as  £6.0m initially, satisfied by £4.0m 
in cash from existing reserves and £2.0m via the issuance of 391,920 new ordinary shares in Instem plc, £0.5m of 
deferred consideration and up to a further £2.0m payable contingent on The Edge’s future trading performance, both 
amounts payable in cash. 

On 20 March 2021, Instem exchanged contracts to acquire US-based clinical trial technology & consulting leader 
d-Wise Technologies, Inc (“d-wise”).  The acquisition   was completed on 1 April 2021. d-wise adds a market leading 
position to the Group in an attractive adjacent area of clinical trial analysis and submission, with good future visibility 
through  recurring  revenue  streams  and  already  contracted,  high  value  consultancy  projects.  In  the  year  ended  31 
December 2020 d-wise had unaudited adjusted profit before tax of $3.1m and adjusted EBITDA of $3.6m on sales of 
$24.1m.  Approximately 30% of revenue was recurring SaaS, hosting services and software support and maintenance. 
As at 31 December 2020, d-wise had net assets of $4.8m. The combined strength of Instem & d-wise positions the 
enlarged Group as the foremost authority and driving force in generating, analysing and leveraging data from Discovery 
through late-stage Clinical Trials. The total consideration is up to $31m comprising $20m on completion, $8m of 
deferred consideration and up to a further $3m which is payable contingent upon the future financial performance of 
d-wise. The initial consideration on completion is being satisfied by $13m in cash and $7m via the issuance of 868,203 
new ordinary shares of 10p each in Instem plc. The cash is being funded from the Group’s existing financial resources.

The results of both acquisitions will be incorporated from the date of acquisition and will be disclosed in the half year 
results to 30 June 2021. 

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D I R E C T O R S   A N D   A D V I S O R S 

D I R E C T O R S
D Gare (Non-Executive Chairman)
M F McGoun (Independent Non-Executive)
D M Sherwin (Non- Executive)
P J Reason
N J Goldsmith

S E C R E T A R Y
N J Goldsmith

R E G I S T E R E D   O F F I C E
Diamond Way
Stone Business Park
Stone
Staffordshire
ST15 0SD
Tel: +44 1785 825600
Fax: +44 1785 825633
www.instem.com

Company No: 07148099

A U D I T O R
Grant Thornton UK LLP
4 Hardman Square
Spinningfields 
Manchester 
M3 3EB

B A N K E R
National Westminster Bank Plc
1 Spinningfields Square
Manchester M2 3AP

N O M I N A T E D   A D V I S O R   A N D   B R O K E R
Nplus1 Singer Advisory LLP
One Bartholomew Lane
London EC2N 2AX

R E G I S T R A R S
Computershare Investor Services PLC
The Pavilions
Bridgewater Road
Bristol BS99 6ZZ

S O L I C I T O R S
Squire Patton Boggs (UK) LLP
No 1 Spinningfields
1 Hardman Square
Manchester M3 3EB

1 0 8

1 0 9

O U R   C L I E N T S

O u r   c l i e n t s 

i n c l u d e   t h e s e   f i n e 

o r g a n i s a t i o n s

1 1 0

I n s t e m   s u p p o r t s   i t s   g l o b a l 

r o s t e r   o f   c l i e n t s   t h r o u g h 

o f f i c e s   i n   t h e   U n i t e d 

S t a t e s ,   U n i t e d   K i n g d o m , 

F r a n c e ,   J a p a n ,   C h i n a   a n d 

I n d i a .

1 1 1

UK

Global Headquarters 

UK & European Operations

Diamond Way

Stone Business Park

Stone

Staffordshire, ST15 0SD

United Kingdom

Tel: +44 (0) 1785 825600

USA

North American Headquarters

Eight Tower Bridge

161 Washington Street

Suite 1550, 15th Floor

Conshohocken, PA 19428

United States

Tel: +1 (610) 941 0990

China

Asia-Pacific Headquarters

Room 218, Building 3

No. 690 Bibo Road

Zhangjiang High-Tech Park

Pudong District

Shanghai

China, 201203

e-mail: investors@instem.com

instem.com